anthracenes

Summary

Summary: A group of compounds with three aromatic rings joined in linear arrangement.

Top Publications

  1. ncbi Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Lasers Surg Med 39:358-64. 2007
  2. pmc Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue
    T L Dutka
    Department of Zoology, La Trobe University, Melbourne, Victoria, Australia
    J Physiol 586:875-87. 2008
  3. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
  4. ncbi KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel
    H S Wang
    Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Science 282:1890-3. 1998
  5. ncbi KCNQ/M currents in sensory neurons: significance for pain therapy
    Gayle M Passmore
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:7227-36. 2003
  6. ncbi Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
    J Guicheux
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 18:2060-8. 2003
  7. pmc Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats
    Wen Xu
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
    Mol Pain 6:49. 2010
  8. pmc Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
    Thomas A Jepps
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 297:G107-15. 2009
  9. ncbi c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes
    Brian G Petrich
    Department of Cell Biology, The Scripps Research Institute, La Jolla, Calif, USA
    Circ Res 91:640-7. 2002
  10. pmc Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
    Lioubov I Brueggemann
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153, USA
    Am J Physiol Lung Cell Mol Physiol 302:L120-32. 2012

Research Grants

  1. GENETICS OF SUSCEPTIBILITY TO SKIN TUMOR PROMOTION
    John DiGiovanni; Fiscal Year: 1990
  2. 5-HT2A RECEPTOR STRUCTURE: AN INTEGRATED APPROACH
    Richard Westkaemper; Fiscal Year: 2006
  3. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
  4. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
  5. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
  6. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
  7. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
  8. Calcium entry and vascular smooth muscle excitation
    KENNETH BYRON; Fiscal Year: 2006
  9. An in-situ gelling nasal vaccine delivery platform
    YAWEI NI; Fiscal Year: 2005
  10. An Inactivated Influenza Nasal Powder Vaccine
    YAWEI NI; Fiscal Year: 2004

Detail Information

Publications273 found, 100 shown here

  1. ncbi Flashlamp pulsed-dye laser suppressed TGF-beta1 expression and proliferation in cultured keloid fibroblasts is mediated by MAPK pathway
    Yur Ren Kuo
    Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan
    Lasers Surg Med 39:358-64. 2007
    ..To further characterize of this involvement, this work examined whether PDL suppression of TGF-beta1 expression was mediated through MAPK pathway in cultured keloid fibroblasts (KF)...
  2. pmc Chloride conductance in the transverse tubular system of rat skeletal muscle fibres: importance in excitation-contraction coupling and fatigue
    T L Dutka
    Department of Zoology, La Trobe University, Melbourne, Victoria, Australia
    J Physiol 586:875-87. 2008
    ..These findings show that the t-system chloride conductance plays a vital role during normal activity by countering the effects of K(+) accumulation in the t-system and maintaining muscle excitability...
  3. pmc SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
    B L Bennett
    Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121 USA
    Proc Natl Acad Sci U S A 98:13681-6. 2001
    ..Our study supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer...
  4. ncbi KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel
    H S Wang
    Institute of Molecular Cardiology, Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, NY 11794, USA
    Science 282:1890-3. 1998
    ..The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current...
  5. ncbi KCNQ/M currents in sensory neurons: significance for pain therapy
    Gayle M Passmore
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:7227-36. 2003
    ..It is suggested that IK(M) plays a key role in controlling the excitability of nociceptors and may represent a novel analgesic target...
  6. ncbi Activation of p38 mitogen-activated protein kinase and c-Jun-NH2-terminal kinase by BMP-2 and their implication in the stimulation of osteoblastic cell differentiation
    J Guicheux
    Division of Bone Diseases, Department of Geriatrics, University Hospital of Geneva, Geneva, Switzerland
    J Bone Miner Res 18:2060-8. 2003
    ..We report that BMP-2 can activate JNK and p38 in osteoblastic cells and provide evidences that these MAP kinases have distinct roles in regulating alkaline phosphatase and osteocalcin expression...
  7. pmc Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats
    Wen Xu
    Department of Neurobiology, Neuroscience Research Institute, Peking University Health Science Center, 38 Xueyuan Road, Beijing 100191, China
    Mol Pain 6:49. 2010
    ....
  8. pmc Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles
    Thomas A Jepps
    Division of Basic Medical Sciences, St George s, University of London, London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 297:G107-15. 2009
    ..Drugs that selectively block K(v)7.4/7.5 might be promising therapeutics for the treatment of motility disorders such as constipation associated with irritable bowel syndrome...
  9. ncbi c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes
    Brian G Petrich
    Department of Cell Biology, The Scripps Research Institute, La Jolla, Calif, USA
    Circ Res 91:640-7. 2002
    ..Our report represents the first evidence, both in vitro and in vivo, implicating JNK as an important mediator of stress-induced Cx43 downregulation and impaired intercellular communication in the failing heart...
  10. pmc Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy
    Lioubov I Brueggemann
    Department of Molecular Pharmacology and Therapeutics, Loyola University Chicago, Maywood, IL 60153, USA
    Am J Physiol Lung Cell Mol Physiol 302:L120-32. 2012
    ....
  11. pmc Vascular KCNQ (Kv7) potassium channels as common signaling intermediates and therapeutic targets in cerebral vasospasm
    Bharath K Mani
    Department of Molecular Pharmacology and Therapeutics, Loyola University, Chicago, Maywood, IL, USA
    J Cardiovasc Pharmacol 61:51-62. 2013
    ..In conclusion, we identify Kv7 channels as common targets of vasoconstrictor spasmogens and as candidates for therapeutic intervention for cerebral vasospasm...
  12. ncbi JNK is constitutively active in mantle cell lymphoma: cell cycle deregulation and polyploidy by JNK inhibitor SP600125
    Miao Wang
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Pathol 218:95-103. 2009
    ..JNK inhibition leads to cell cycle deregulation and endoreduplication, mimicking the tetraploid state seen in a subset of MCL cases. Thus, our data also provide an experimental model to study polyploid MCL cells...
  13. ncbi KCNQ/M channels control spike afterdepolarization and burst generation in hippocampal neurons
    Cuiyong Yue
    Department of Physiology, Institute of Medical Sciences, Hebrew University Hadassah Faculty of Medicine, Jerusalem 91120, Israel
    J Neurosci 24:4614-24. 2004
    ..Consequently, down-modulation of KCNQ/M channels converts the neuronal firing pattern from simple to complex spiking, whereas up-modulation of these channels exerts the opposite effect...
  14. ncbi Cross-talk between phosphatidylinositol 3-kinase/AKT and c-jun NH2-terminal kinase mediates survival of isolated human islets
    Reid Aikin
    Department of Surgery, Montreal General Hospital, Room C9 128, 1650 Cedar Avenue, Montreal, Quebec, Canada H3G 1A4
    Endocrinology 145:4522-31. 2004
    ..Taken together, these results demonstrate that PI3K/AKT suppresses the JNK pathway in islets, and this cross-talk represents an important antiapoptotic consequence of PI3K/AKT activation...
  15. ncbi Cell-type specific modulation of intrinsic firing properties and subthreshold membrane oscillations by the M(Kv7)-current in neurons of the entorhinal cortex
    Motoharu Yoshida
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurophysiol 98:2779-94. 2007
    ..Modulation of the M-current thus shifts the firing behavior, intrinsic excitability, and subthreshold membrane potential oscillations of EC principal cells in a cell-type-dependent manner...
  16. pmc SP600125 suppresses Cdk1 and induces endoreplication directly from G2 phase, independent of JNK inhibition
    J A Kim
    Sidney Kimmel Cancer Center, San Diego, CA, USA
    Oncogene 29:1702-16. 2010
    ..Furthermore, endoreplication from G2 phase is independent of p53 control...
  17. ncbi Functional effects of the KCNQ modulators retigabine and XE991 in the rat urinary bladder
    Frederik Rode
    Neurosearch A S, Ballerup, Denmark
    Eur J Pharmacol 638:121-7. 2010
    ..In conclusion, this study demonstrates an efficacious KCNQ dependent effect of retigabine and XE991 on rat bladder contractility...
  18. pmc Electrophysiological and functional effects of the KCNQ channel blocker XE991 on murine portal vein smooth muscle cells
    Shuk Yin M Yeung
    Department of Basic Medical Sciences, St George s University of London, Cranmer Terrace, London SW17 0RE
    Br J Pharmacol 146:585-95. 2005
    ..The stimulatory effect of XE991 was not affected by the presence of 4-AP, glibenclamide nor paxilline. These data provide evidence for an important role for KCNQ channels in governing cellular excitability in mPV smooth muscle cells...
  19. ncbi Inhibition of basal p38 or JNK activity enhances epithelial barrier function through differential modulation of claudin expression
    Fabio Carrozzino
    Dept of Cell Physiology and Metabolism, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Am J Physiol Cell Physiol 297:C775-87. 2009
    ....
  20. pmc Identification of a fluorescent general anesthetic, 1-aminoanthracene
    Christopher A Butts
    Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:6501-6. 2009
    ..Thus, 1-AMA provides an unprecedented opportunity for studying general anesthetic distribution in vivo at the cellular and subcellular levels...
  21. ncbi SP600125, a new JNK inhibitor, protects dopaminergic neurons in the MPTP model of Parkinson's disease
    Wenya Wang
    Department of Pharmacology, Zhongshan Medical College, Sun Yat Sen University, No 74 Zhongshan Road 2, Guangzhou 510089, China
    Neurosci Res 48:195-202. 2004
    ..These results indicate that JNK pathway is the major mediator of the neurotoxic effects of MPTP in vivo and inhibiting JNK activity may represent a new and effective strategy to treat PD...
  22. ncbi Inhibition of JNK reduces G2/M transit independent of p53, leading to endoreduplication, decreased proliferation, and apoptosis in breast cancer cells
    Amy M Mingo-Sion
    School of Pharmacy, University of Colorado Health Sciences Center, 4200 East Ninth Avenue, Campus Box C238, Denver, CO 80262, USA
    Oncogene 23:596-604. 2004
    ....
  23. pmc Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents
    Sym Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s University of London, London, UK
    Br J Pharmacol 155:62-72. 2008
    ..This study investigated the functional and electrophysiological effects of the Kv7 channel activator, retigabine, on murine portal vein smooth muscle...
  24. ncbi Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells
    Yumi Miyamoto-Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    Cell Biol Int 31:1501-6. 2007
    ..Our data show that basic JNK activity plays an important role in the progression of the cell cycle at G2/M cell phase...
  25. ncbi Acetylcholinesterase expression mediated by c-Jun-NH2-terminal kinase pathway during anticancer drug-induced apoptosis
    R Deng
    State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Oncogene 25:7070-7. 2006
    ..Together, these results suggest that AChE expression may be mediated by the activation of JNK pathway during apoptosis through a c-Jun-dependent mechanism...
  26. ncbi Apoptosis signal-regulating kinase 1 is mediated in TNF-α-induced CCL2 expression in human synovial fibroblasts
    Hsi Kai Tsou
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
    J Cell Biochem 113:3509-19. 2012
    ..Our results suggest that the interaction between TNF-α and TNFR1 increases CCL2 expression in human synovial fibroblasts via the ASK1, JNK/p38, c-Jun, and AP-1 signaling pathway...
  27. pmc Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity
    S Y M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London, UK
    Br J Pharmacol 151:758-70. 2007
    ..This study represents a novel characterisation of KCNQ-encoded potassium channels in the vasculature using a variety of pharmacological and molecular tools to determine their role in contractility...
  28. ncbi SP600125, an inhibitor of c-Jun NH2-terminal kinase, blocks expression of angiotensin II-induced monocyte chemoattractant protein-1 in human mesangial cells
    Gui Xia Ding
    Department of Nephrology, Nanjing Children s Hospital, Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China
    World J Pediatr 6:169-76. 2010
    ....
  29. pmc Neuromodulation of I(h) in layer II medial entorhinal cortex stellate cells: a voltage-clamp study
    James G Heys
    Center for Memory and Brain, Graduate Program for Neuroscience, Department of Psychology, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 32:9066-72. 2012
    ..The results from this study provide key insights into a potential mechanism that could be underlying changes seen in grid field spacing during distinct behavioral contexts...
  30. ncbi Expression profile and characterisation of a truncated KCNQ5 splice variant
    Shuk Yin M Yeung
    Division of Basic Medical Sciences, Ion Channels and Cell Signalling Research Centre, St George s, University of London, London SW17 0RE, UK
    Biochem Biophys Res Commun 371:741-6. 2008
    ..These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature...
  31. ncbi c-Jun NH2-terminal kinase inhibitor anthra(1,9-cd)pyrazol-6(2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages
    Aleksi Lahti
    The Immunopharmacological Research Group, University of Tampere Medical School, Tampere, Finland
    Mol Pharmacol 64:308-15. 2003
    ..These results show that the JNK pathway is involved in the up-regulation of LPS-induced iNOS expression and NO production by a mechanism related to the stabilization of iNOS mRNA...
  32. pmc KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier
    J R Schwarz
    Institute of Applied Physiology, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    J Physiol 573:17-34. 2006
    ..We conclude that the nodal I(Ks) current is mediated by KCNQ channels, which in large fibres of rat sciatic nerve appear to be KCNQ2 homomers...
  33. pmc KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons
    Cynthia L Wladyka
    Rammelkamp Centre for Research and Education R326 MetroHealth Medical Centre, 2500 MetroHealth Drive, Cleveland, OH 44109 1998, USA
    J Physiol 575:175-89. 2006
    ..These data indicate that the M-current is present in nodose neurons, is activated at resting membrane potential and that it is physiologically important in regulating excitability by maintaining cells at negative voltages...
  34. ncbi Contribution of mitogen-activated protein kinases to NMDA-induced neurotoxicity in the rat retina
    Yasunari Munemasa
    Department of Ophthalmology, Saint Marianna University School of Medicine, 2 16 1 Sugao, Kawasaki shi, Kanagawa 216 8511, Japan
    Brain Res 1044:227-40. 2005
    ..0 nmol U0126) did not suppress NMDA-induced cell death in the RGCL nor thinning of the IPL. These findings suggest that JNK and p38 are proapoptotic in NMDA-induced cell death in the RGCL, but not ERK...
  35. ncbi c-Jun N-terminal kinase 2 phosphorylates endothelial nitric oxide synthase at serine 116 and regulates nitric oxide production
    Jung Hyun Park
    Department of Molecular Medicine and Ewha Medical Research Institute, Ewha Womans University Medical School, Seoul, South Korea
    Biochem Biophys Res Commun 417:340-5. 2012
    ..However, all these observed effects were not manifested when JNK1 probes were used. Overall, this study indicates that JNK2 is a physiological kinase responsible for eNOS-Ser(116) phosphorylation and regulates NO production...
  36. ncbi NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance
    Rui Xian Guo
    Department of Physiology, Zhongshan Medical College, Sun Yat Sen University, 74, Zhongshan 2nd Road, Guangzhou 510080, PR China
    Neurosci Lett 467:95-9. 2009
    ....
  37. ncbi Toll-like receptor ligands cause proinflammatory and prodiabetic activation of adipocytes via phosphorylation of extracellular signal-regulated kinase and c-Jun N-terminal kinase but not interferon regulatory factor-3
    Andrea Kopp
    Department of Internal Medicine I, University of Regensburg, D 93042 Regensburg, Germany
    Endocrinology 151:1097-108. 2010
    ..TLR-ligand-induced proinflammatory and prodiabetic activation of adipocytes might couple visceral adipose tissue dysfunction with insulin resistance and type 2 diabetes mellitus...
  38. ncbi Photochemical ligation of DNA conjugates through anthracene cyclodimer formation and its fidelity to the template sequences
    Toshihiro Ihara
    Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
    J Am Chem Soc 126:8880-1. 2004
    ..The conjugates were only dimerized in the presence of the template by light irradiation. The efficiency was affected by one-base displacement in the template sequence...
  39. ncbi Reversible circularization of an anthracene-modified DNA conjugate through bimolecular triplex formation and its analytical application
    Pelin Arslan
    Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
    Org Biomol Chem 8:4843-8. 2010
    We prepared an oligodeoxyribonucleotide conjugate (5-3ant(2)18) carrying two anthracenes, each of which was tethered to both ends of the conjugate through hexamethylene linker chains...
  40. ncbi Detection of single nucleotide polymorphisms within a sequence of a gene associated with prostate cancer using a fluorophore-tagged DNA probe
    Zheng yun Zhao
    School of Chemistry, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Bioorg Med Chem Lett 22:129-32. 2012
    ....
  41. ncbi The Jun N-terminal kinase inhibitor SP600125 is a ligand and antagonist of the aryl hydrocarbon receptor
    Aby Joiakim
    Institute of Environmental Health Sciences, Wayne State University, 2727 Second Ave, Rm 4000, Detroit, MI 48201, USA
    Drug Metab Dispos 31:1279-82. 2003
    ..These results suggest that SP600125 is an AhR ligand and functions as an AhR antagonist at concentrations used to pharmacologically inhibit JNK...
  42. ncbi Anthracene-DNA conjugates as building blocks of designed DNA structures constructed by photochemical reactions
    Motoko Mukae
    Department of Applied Chemistry and Biochemistry, Graduate School of Science and Technology, Kumamoto University, 2 39 1 Kurokami, Kumamoto 860 8555, Japan
    Org Biomol Chem 7:1349-54. 2009
    ..the photochemical ligation of anthracene-ODN (oligodeoxyribonucleotide) conjugates through cycloaddition of anthracenes. Anthracene-DNA conjugates were synthesized by linking the 5'- or 3'-end of ODNs to the anthracene group...
  43. ncbi Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest
    Christian Kuntzen
    Department of Internal Medicine II, University Hospital Grosshadern, Ludwig Maximilians University, Munich, Germany
    Cancer Res 65:6780-8. 2005
    ..We conclude that JNK inhibition has antitumor activity by inducing growth arrest and enhancing CD95-mediated apoptosis by a transcription-independent mechanism...
  44. ncbi Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current
    M S Shapiro
    Department of Physiology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Neurosci 20:1710-21. 2000
    ..Our data further rule out Ca(2+) as the diffusible messenger. The reconstitution of muscarinic modulation of the M current that uses cloned components should facilitate the elucidation of the muscarinic signaling mechanism...
  45. ncbi M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals
    Maria Martire
    Institute of Pharmacology, School of Medicine, Catholic University of Sacred Heart, 00168 Rome, Italy
    J Neurosci 24:592-7. 2004
    ..These findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings...
  46. ncbi c-Jun N-terminal kinase contributes to norepinephrine-induced contraction through phosphorylation of caldesmon in rat aortic smooth muscle
    Youn Ri Lee
    Department of Physiology, College of Medicine, Institute of Biomedical Science and Technology, Konkuk University, Chungju, Choong Buk, Korea
    J Pharmacol Sci 100:119-25. 2006
    ..These results show that JNK contributes to NE-mediated contraction through phosphorylation of caldesmon in rat aortic smooth muscle, and that this effect is regulated by the PKC pathway, especially cPKC...
  47. pmc Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
    Yong Seok Heo
    The Division of Drug Discovery, CrystalGenomics, Inc, Daeduk Biocommunity, Jeonmin dong, Daejon, Korea
    EMBO J 23:2185-95. 2004
    ..In addition, we also determined the ternary complex structure of pepJIP1-bound JNK1 complexed with SP600125, an ATP-competitive inhibitor of JNK, providing the basis for the JNK specificity of the compound...
  48. ncbi Inhibitors of c-Jun N-terminal kinases: JuNK no more?
    Marie A Bogoyevitch
    Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, Victoria, Australia
    Biochim Biophys Acta 1784:76-93. 2008
    ..We conclude by raising a number of questions that should be considered in the quest for JNK-specific inhibitors...
  49. ncbi Anthracene-BODIPY dyads as fluorescent sensors for biocatalytic Diels-Alder reactions
    Alexander Nierth
    Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, Heidelberg 69120, Germany
    J Am Chem Soc 132:2646-54. 2010
    ..Variations in the quantum yields of the different probes correlate well with the degree of conjugation between anthracene and the phenylacetylenyl bridge...
  50. ncbi Inhibition of hippocampal Jun N-terminal kinase enhances short-term memory but blocks long-term memory formation and retrieval of an inhibitory avoidance task
    Lia R M Bevilaqua
    Centro de Memoria, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Ramiro Barcellos 2600 Anexo Porto Alegre, RS 90035 003, Brazil
    Eur J Neurosci 17:897-902. 2003
    ..No action of this drug on locomotor/exploratory activity or general anxiety state could be detected. The significance of these results is discussed in the context of others describing the independence of LTM from STM...
  51. ncbi Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125
    Matthew L H Chu
    School of Pharmacy and Pharmaceutical Sciences, Stopford Building, University of Manchester, Manchester, UK
    J Biol Chem 283:21495-500. 2008
    ..These structures provide important insights into the interaction of this protein kinase with small molecules and suggest potential mechanisms for Mps1 regulation...
  52. ncbi The role of c-Jun N-terminal kinases 1/2 in transforming growth factor beta(1)-induced expression of connective tissue growth factor and scar formation in the cornea
    Y Chang
    Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan City, China
    J Int Med Res 37:727-36. 2009
    ..Analysis by real-time reverse transcription-polymerase chain reaction showed that the mRNA levels of the genes for CTGF, fibronectin and collagen Ialpha(1) in wound and corneal scar formation were reduced by SP600125 pre-treatment...
  53. ncbi C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts
    Mitsuyoshi Utsugi
    First Department of Internal Medicine, Gunma University Faculty of Medicine, School of Medicine, 3 39 15 Showa Machi, Maebashi, Gunma, 371 8511, Japan
    Am J Respir Cell Mol Biol 28:754-61. 2003
    ..These results suggest that TGF-beta1-induced CTGF mRNA expression is mediated through the JNK-dependent pathway, whereas p38 MAP kinase and ERK pathways minimally contribute...
  54. ncbi Inhibition of Jun N-terminal kinase (JNK) enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells
    Xiaohong Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 30:242-9. 2005
    ..Moreover, JNK pathways may represent a therapeutic target for normalization of GR function in these disorders...
  55. ncbi Kv7/KCNQ channels control action potential phasing of pyramidal neurons during hippocampal gamma oscillations in vitro
    Richardson N Leao
    Department of Neuroscience, Neuronal Oscillations Laboratory, Karolinska Institute, 17177 Stockholm, Sweden
    J Neurosci 29:13353-64. 2009
    ..We further validate these results in a compartmental model of a pyramidal neuron. Our work suggests that I(M) modulates gamma oscillations by regulating the phasing of action potential firing in pyramidal neurons...
  56. pmc Regulation of JNK activity in the apoptotic response of intestinal epithelial cells
    Ramesh M Ray
    Dept of Physiology, Univ of Tennessee Health Science Center, Memphis, 38163, USA
    Am J Physiol Gastrointest Liver Physiol 300:G761-70. 2011
    ..Taken together, these results suggest that MKP1 activity determines the duration of JNK1/2 and p38 activation and, thereby, apoptosis in response to TNF + CPT...
  57. ncbi New anthracene derivatives from Coussarea macrophylla
    Ximena Chiriboga
    Facultad de Ciencias Quimicas, Universidad Central del Ecuador, Quito, Ecuador
    J Nat Prod 66:905-9. 2003
    ..The structures of 1-5 were determined on the basis of analysis of their spectroscopic data and by total synthesis...
  58. ncbi Characterization of an RNA active site: interactions between a Diels-Alderase ribozyme and its substrates and products
    Friedrich Stuhlmann
    Department of Biology, Chemistry and Pharmacy, Institute of Chemistry, Free University of Berlin, Thielallee 63, D 14195 Berlin, Germany
    J Am Chem Soc 124:3238-44. 2002
    ..Taken together, the results highlight the intricacy of ribozyme active sites which can control chemical reaction pathways based on minute differences in substrate stereochemistry and substitution pattern...
  59. ncbi Retigabine reduces the excitability of unmyelinated peripheral human axons
    P M Lang
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Neuropharmacology 54:1271-8. 2008
    ..It is likely that activation of these channels by retigabine may reduce the ectopic generation of action potentials in neuropathic pain...
  60. ncbi Direct observation of organic contaminant uptake, storage, and metabolism within plant roots
    Edward Wild
    Department of Environmental Science, Lancaster University, Lancaster, LA1 4YQ, UK
    Environ Sci Technol 39:3695-702. 2005
    ..The technique and observations have important applications to the fields of agrochemistry and phytoremediation...
  61. ncbi A role for c-Jun N-terminal kinase in the inhibition of long-term potentiation by interleukin-1beta and long-term depression in the rat dentate gyrus in vitro
    B P Curran
    Department of Human Anatomy and Physiology, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Earlsfort Terrace, Dublin 2, Ireland
    Neuroscience 118:347-57. 2003
    ..Whereas acute over-activation of JNK by pathophysiological concentrations of cytokines is detrimental to LTP, physiologic activation of JNK appears necessary for the induction of LTD...
  62. ncbi Modulation of ERG channels by XE991
    Pernille Elmedyb
    Department of Medical Physiology, The Panum Institute, The University of Copenhagen, Denmark
    Basic Clin Pharmacol Toxicol 100:316-22. 2007
    ..In conclusion, great care should be taken when choosing the concentration of XE991 to use for experiments on native potassium channels or animal studies in order to be able to conclude on selective KCNQ channel-mediated effects...
  63. ncbi Requirement for ERK activation in acetone extract identified from Bupleurum scorzonerifolium induced A549 tumor cell apoptosis and keratin 8 phosphorylation
    Yi Lin Chen
    Graduate Institution of Medical Science, Tzu Chi University, Hualian, Taiwan
    Life Sci 76:2409-20. 2005
    ..The molecular mechanism of hyperphosphorylation of K8 on Ser-73 was associated with ERK 1/2 activation rather than JNK and p38 kinase. The apoptosis induced by AE-BS may be related to K8 phosphorylation...
  64. ncbi Assessment of anthracene toxicity toward environmental eukaryotic microorganisms: Tetrahymena pyriformis and selected micromycetes
    J L Bonnet
    Laboratoire de Biologie Cellulaire, Faculte de Pharmacie, Universite d Auvergne, 28 Place Henri Dunant, BP38, 63001 Clermont Ferrand, Cedex 1, France
    Ecotoxicol Environ Saf 60:87-100. 2005
    ..pyriformis and the different micromycetes...
  65. pmc Ablation of the spindle assembly checkpoint by a compound targeting Mps1
    Marc Schmidt
    Division of Molecular Biology, H8, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO Rep 6:866-72. 2005
    ..Remarkably, primary human cells are largely resistant to the checkpoint-inactivating action of SP600125, suggesting the existence of Mps1-independent checkpoint pathways that are compromised in tumour cells...
  66. pmc Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
    Daolin Tang
    Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China
    J Leukoc Biol 81:741-7. 2007
    ..Together, these data establish an important role for oxidative stress in inducing active HMGB1 release, potentially through a MAPK- and CRM1-dependent mechanism...
  67. ncbi Antimicrobial prenylated anthracene derivatives from the leaves of Harungana madagascariensis
    Simeon F Kouam
    Department of Chemistry, Higher Teachers Training College, University of Yaounde 1, BP 47, Yaounde, Cameroon
    J Nat Prod 70:600-3. 2007
    ..Compounds 2, 4, and 6 were strongly active against the Gram-positive Bacillus megaterium...
  68. ncbi JNK1 contributes to metabotropic glutamate receptor-dependent long-term depression and short-term synaptic plasticity in the mice area hippocampal CA1
    Xin Mei Li
    Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, PR China
    Eur J Neurosci 25:391-6. 2007
    ..These results demonstrated that JNK1 played a crucial role in the short-term synaptic plasticity and mGluR-dependent LTD, whereas hippocampus LTP was not affected by JNK1 deficiency...
  69. ncbi Characterization of M-current in ventral tegmental area dopamine neurons
    Susumu Koyama
    Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60612 7342, USA
    J Neurophysiol 96:535-43. 2006
    ..In conclusion, I(M) is active near threshold in DA VTA neurons, is blocked by XE991 (10 microM) and TEA (10 mM), may contribute to the shape of the AHP, and may decrease excitability of these neurons...
  70. pmc The KCNQ/M-current modulates arterial baroreceptor function at the sensory terminal in rats
    Cynthia L Wladyka
    Rammelkamp Center for Research and Education R326, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH 44109 1998, USA
    J Physiol 586:795-802. 2008
    ..We propose that KCNQ2, KCNQ3 and KCNQ5 channels provide a hyperpolarizing influence to offset the previously described depolarizing influence of the HCN channels in baroreceptor neurons and their terminals...
  71. pmc Kv7/KCNQ/M-channels in rat glutamatergic hippocampal axons and their role in regulation of excitability and transmitter release
    K Vervaeke
    Department of Physiology at IMB and Centre for Molecular Biology and Neuroscience, CMBN, University of Oslo, PB 1103 Blindern, N 0317 Oslo, Norway
    J Physiol 576:235-56. 2006
    ..Our results indicate that functional Kv7/KCNQ/M-channels are present in unmyelinated axons in the brain, and that these channels may have contrasting effects on excitability depending on their subcellular localization...
  72. ncbi P-glycoprotein down-regulates expression of breast cancer resistance protein in a drug-free state
    Hyun Bark
    Research Center for Resistant Cells and Department of Pharmacology, Chosun University Medical School, Gwangju, Republic of Korea
    FEBS Lett 582:2595-600. 2008
    ..Dominant negative c-Jun decreased the expression of BCRP, but increased that of Pgp. These results indicate that Pgp down-regulates BCRP expression in a drug-free state in which JNK/c-Jun is involved...
  73. pmc c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis
    Z Han
    Division of Rheumatology, Allergy and Immunology, University of California, San Diego, School of Medicine, La Jolla, California 92093, USA
    J Clin Invest 108:73-81. 2001
    ..Therefore, JNK is a critical MAPK pathway for IL-1--induced collagenase gene expression in synoviocytes and in joint arthritis, indicating that JNK is an important therapeutic target for RA...
  74. doi DNA and RNA can be equally efficient catalysts for carbon-carbon bond formation
    Madhavaiah Chandra
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Am Chem Soc 130:2936-7. 2008
  75. ncbi Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes
    Jamie B Scaglione
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 51:1309-18. 2008
    ....
  76. ncbi The pivotal role of c-Jun NH2-terminal kinase-mediated Beclin 1 expression during anticancer agents-induced autophagy in cancer cells
    D D Li
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, China
    Oncogene 28:886-98. 2009
    ..JNK-mediated Beclin 1 expression was also observed in topotecan-induced autophagy. These data suggest that activation of JNK pathway can mediate Beclin 1 expression, which plays a key role in autophagic cell death in cancer cells...
  77. ncbi JNK as a positive regulator of angiogenic potential in endothelial cells
    Cassandra Uchida
    School of Kinesiology and Health Sciences, York University, Farquharson Room 341, 4700 Keele Street, Toronto, ON, Canada M3J 1P3
    Cell Biol Int 32:769-76. 2008
    ..Taken together, these results provide evidence that JNK and its downstream target c-jun positively regulate angiogenesis via activation of endothelial cell proliferation, migration and proteolysis...
  78. ncbi The neuroprotective action of SP600125, a new inhibitor of JNK, on transient brain ischemia/reperfusion-induced neuronal death in rat hippocampal CA1 via nuclear and non-nuclear pathways
    Qiu Hua Guan
    Department of Neurobiology and Biophysics, School of Life Science, University of Science and Technology of China, Hefei 230027, PR China
    Brain Res 1035:51-9. 2005
    ..Thus, inhibiting JNK activity by SP600125 may represent a new and effective strategy to treat ischemic stoke...
  79. ncbi Inhibition of c-Jun N-terminal kinase limits lipopolysaccharide-induced pulmonary neutrophil influx
    Patrick G Arndt
    Division of Pulmonary and Critical Care Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80206, USA
    Am J Respir Crit Care Med 171:978-86. 2005
    ....
  80. ncbi Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-kappaB-inducing kinases
    Li Fu Li
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am J Physiol Lung Cell Mol Physiol 285:L464-75. 2003
    ..We conclude that stretch-induced transcriptional regulation of IL-8 mRNA and IL-8 production was via activation of AP-1 and NF-kappaB and was dependent on JNK and NIK activation, respectively...
  81. pmc Reducing chloride conductance prevents hyperkalaemia-induced loss of twitch force in rat slow-twitch muscle
    Maarten Geert van Emst
    Department of Pathobiology, Division of Anatomy and Physiology, Faculty of Veterinary Medicine, Utrecht University, P O Box 80 158, 3508 TD Utrecht, The Netherlands
    J Physiol 561:169-81. 2004
    ..It might exert a stabilizing influence on force production during short periods of hyperkalaemia, but it can add to the loss of force during prolonged periods of hyperkalaemia...
  82. ncbi The effects of anthracene and methylated anthracenes on gap junctional intercellular communication in rat liver epithelial cells
    B L Upham
    Department of Pediatrics and Human Development, Michigan State University, East Lansing, Michigan, 48824, USA
    Fundam Appl Toxicol 34:260-4. 1996
    ..A rich source of PAHs is cigarette smoke, which contains methylated anthracenes and phenanthrenes as the predominant PAHs...
  83. ncbi Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells
    Sheng Huei Yang
    Faculty of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Leuk Res 31:1413-20. 2007
    ..Taken together, our data show that JNK plays an important role in IQDMA-mediated G2/M arrest and apoptosis of K562 cancer cells...
  84. ncbi Molecular basis for differential sensitivity of KCNQ and I(Ks) channels to the cognitive enhancer XE991
    H S Wang
    Department of Physiology and Biophysics, Institute of Molecular Cardiology, State University of New York, Stony Brook, NY 11794 8661, USA
    Mol Pharmacol 57:1218-23. 2000
    ..Our results have implications for drug development by demonstrating the important potential role of accessory subunits in determining the pharmacological properties of KCNQ channels...
  85. ncbi Ventilation-induced neutrophil infiltration depends on c-Jun N-terminal kinase
    Li Fu Li
    Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Respir Crit Care Med 169:518-24. 2004
    ..We conclude that lung cell stretch in vivo results in increased lung neutrophil sequestration and increased MIP-2 production, which was, at least in part, dependent upon the JNK pathway...
  86. ncbi Thimerosal-induced apoptosis in human SCM1 gastric cancer cells: activation of p38 MAP kinase and caspase-3 pathways without involvement of [Ca2+]i elevation
    Shiuh Inn Liu
    Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan 813
    Toxicol Sci 100:109-17. 2007
    ..The results suggest that in SCM1 cells, thimerosal caused Ca2+-independent apoptosis via phosphorylating p38 MAPK resulting in caspase-3 activation...
  87. ncbi Evaluation of the anti-inflammatory and cytotoxic effects of anthraquinones and anthracenes derivatives in human leucocytes
    Rong Fu Chen
    Department and Institute of Pharmacology, National Yang Ming University, Taipei, Taiwan
    J Pharm Pharmacol 56:915-9. 2004
    ..This is the first demonstration that derivatives modified from anthracenes or anthraquinones possess anti-inflammatory activity with no significant cytotoxicity in human neutrophils.
  88. ncbi Comparison between ischaemic and anisomycin-induced preconditioning: role of p38 MAPK
    A Lochner
    MRC Diabetes Research Group, Tygerberg, Republic of South Africa
    Cardiovasc Drugs Ther 17:217-30. 2003
    ..The results indicate that activation of p38 MAPK acts as a trigger of preconditioning, while attenuation of its activation is a prerequisite for improved recovery and a reduction in infarct size...
  89. ncbi Dendron arrays for the force-based detection of DNA hybridization events
    Yu Jin Jung
    Center for Integrated Molecular Systems, Department of Chemistry, Pohang University of Science and Technology, San 31 Hyoja Dong, Pohang, Korea
    J Am Chem Soc 129:9349-55. 2007
    ..Combined with a narrow distribution of both attractive forces and unbinding forces we suggest such functionalized surfaces offer a significant advance for fast and accurate force-based studies of oligonucleotide hybridization...
  90. ncbi Spectroscopic identification of binding modes of anthracene probes and DNA sequence recognition
    Willy B Tan
    Department of Chemistry, University of Connecticut, Storrs, CT 06269 3060, USA
    Photochem Photobiol 82:20-30. 2006
    ..The characteristic spectroscopic signatures of the two distinct binding modes of these probes will be helpful in deciphering the interaction of other anthracene derivatives with DNA...
  91. ncbi Architecture of a Diels-Alderase ribozyme with a preformed catalytic pocket
    Sonja Keiper
    Universitat Heidelberg, Institut für Pharmazie und molekulare Biotechnologie, D 69120 Heidelberg, Germany
    Chem Biol 11:1217-27. 2004
    ..It is proposed that the catalytic pocket is formed by a wedge within one of these helices...
  92. pmc Chloride conductance in normal and myotonic muscle fibres and the action of monocarboxylic aromatic acids
    S H Bryant
    J Physiol 219:367-83. 1971
    ..5. Anthracene-9-carboxylic acid intravenously (8 mg/kg) in normal goats produced acutely a condition resembling myotonia congenita. The carboxylic acids produced no myotonic effects in frog muscle...
  93. ncbi Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies
    Yan Zeng
    Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Biochem J 413:429-36. 2008
    ..These results suggest a potential regulatory mechanism for RNA silencing acting through Ago2 serine-387 phosphorylation mediated by the p38 MAPK pathway...
  94. ncbi Differential transcriptional responses of keloid and normal keratinocytes to serum stimulation
    Wei Xia
    Department of Surgery, Stanford University Medical School, Stanford, California, USA
    J Surg Res 135:156-63. 2006
    ..We used the transcriptional response to serum stimulation to examine how TGF-beta expression is stimulated in KKs...
  95. pmc Interleukin-1 beta up-regulates tissue inhibitor of matrix metalloproteinase-1 mRNA and phosphorylation of c-jun N-terminal kinase and p38 in hepatic stellate cells
    Ya Ping Zhang
    Department of Gastroenterology, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China
    World J Gastroenterol 12:1392-6. 2006
    ....
  96. ncbi The effects of ZD1839 (Iressa), a highly selective EGFR tyrosine kinase inhibitor, as a radiosensitiser in bile duct carcinoma cell lines
    Hideki Miyata
    Department of Medicine and Molecular Science, Division of Frontier Medical Science, Programs for Biochemical Research, Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Hiroshima 734 8551, Japan
    Int J Oncol 28:915-21. 2006
    ..These results suggest that AKT may be a useful target molecule for enhancement of radiotherapy effect and that ZD1839 may have an important role in combination with radiotherapy for patients with bile duct carcinoma...
  97. ncbi In vitro, inhibition of mitogen-activated protein kinase pathways protects against bupivacaine- and ropivacaine-induced neurotoxicity
    Philipp Lirk
    Department of Anesthesiology and Critical Care Medicine, Innsbruck Medical University, Anichstr 35, 6020 Innsbruck, Austria
    Anesth Analg 106:1456-64, table of contents. 2008
    ....
  98. ncbi PPARgamma phosphorylation mediated by JNK MAPK: a potential role in macrophage-derived foam cell formation
    Ran Yin
    Department of Cardiology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Acta Pharmacol Sin 27:1146-52. 2006
    ....
  99. ncbi Oridonin induced autophagy in human cervical carcinoma HeLa cells through Ras, JNK, and P38 regulation
    Qiao Cui
    China Japan Research Institute of Medical Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, PR China
    J Pharmacol Sci 105:317-25. 2007
    ..Raf-1 and ERK1/2 had no obvious correlation to these signaling pathways...
  100. ncbi Phorbol 12-myristate 13-acetate-activated protein kinase C increased migratory activity of subconjunctival fibroblasts via stress-activated protein kinase pathways
    Naoko Nomura
    Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Mol Vis 13:2320-7. 2007
    ..The aim of this study was to clarify the mechanism of subconjunctival fibroblast migration, focusing on the effect of protein kinase C (PKC)...
  101. ncbi EGCG-targeted p57/KIP2 reduces tumorigenicity of oral carcinoma cells: role of c-Jun N-terminal kinase
    Tetsuya Yamamoto
    Department of Oral Surgery, Faculty of Medicine, Kochi University, Kohasu, Nakoku city, Kochi 783, Japan
    Toxicol Appl Pharmacol 224:318-25. 2007
    ..These results suggest that p57 expression may be an useful indicator for the clinical course of cancers, and could be potentially useful as a target for cancer therapies...

Research Grants33

  1. GENETICS OF SUSCEPTIBILITY TO SKIN TUMOR PROMOTION
    John DiGiovanni; Fiscal Year: 1990
    ....
  2. 5-HT2A RECEPTOR STRUCTURE: AN INTEGRATED APPROACH
    Richard Westkaemper; Fiscal Year: 2006
    ..This is one of the first times that a combined approach, utilizing receptor modeling, model-specific ligand design, and model-directed mutagenesis, has been applied to 5-HT receptors. ..
  3. POTASSIUM CHANNELS AND CEREBRAL HEMODYNAMICS AFTER BRAIN
    William Armstead; Fiscal Year: 2005
    ..These studies may lead to therapies for brain injured children. ..
  4. Plasminogen activators and cerebral ischemic injury
    William M Armstead; Fiscal Year: 2010
    ....
  5. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  6. Transmitter Repletion: Key to Phrenic-Diaphragm Function
    Erik van Lunteren; Fiscal Year: 2005
    ..These studies may lead to novel therapeutic approaches to respiratory muscle impairment and resulting hypercapnic respiratory failure for conditions which produce neuromuscular junction dysfunction. ..
  7. Zebrafish Screen for Neuroprotective Anti-oxidants
    Chuenlei Parng; Fiscal Year: 2005
    ..Assessment of drug effects in a convenient vertebrate model, prior to evaluation in a complex system, such as mouse, can potentially streamline the drug development process and dramatically reduce costs. ..
  8. Calcium entry and vascular smooth muscle excitation
    KENNETH BYRON; Fiscal Year: 2006
    ..abstract_text> ..
  9. An in-situ gelling nasal vaccine delivery platform
    YAWEI NI; Fiscal Year: 2005
    ..These studies will form the basis for phase II development of this platform targeting demonstration of safety and efficacy against selected pathogens that have significant unmet medical and biodefense needs in humans. ..
  10. An Inactivated Influenza Nasal Powder Vaccine
    YAWEI NI; Fiscal Year: 2004
    ..Completion of these preclinical studies will form the basis for an IND submission. ..
  11. Role of ornithine decarboxylase in Ras transformation
    Lisa Shantz; Fiscal Year: 2006
    ..Keratinocytes from D1/AZ mice will also be used to analyze direct interactions of AZ with cyclin D1, to test whether other properties of AZ are important for deregulation of cell proliferation in tumor development. ..
  12. ASSAY FOR DETERMINING DRUG TOXICITY
    Chuenlei Parng; Fiscal Year: 2004
    ..abstract_text> ..
  13. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
    ..Previous studies supported under the AREA program emphasized cyclopenta[a]phenanthrenes, benzo[a]anthracenes, chrysenes, methylene bridged-PAHs and fluoranthene-PAHs, having varied degrees of carcinogenic, mutagenic and ..
  14. NUTRIENT EFFECTS ON INSULIN ACTION
    Michael Pagliassotti; Fiscal Year: 2009
    ..abstract_text> ..
  15. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  16. SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLS
    KENNETH BYRON; Fiscal Year: 2002
    ..Finally, the effects of AVP and other hormones on [Ca2+]i and membrane currents will be examined in freshly isolated smooth muscle cells from rat mesenteric arteries. ..
  17. ENDOTOXIN AND SUSCEPTIBILITY TO TRICHOTHECENE MYCOTOXINS
    James Pestka; Fiscal Year: 2002
    ..Over the long term, this research will provide insight into adverse immunologic consequences that may occur in LPS-exposed individuals who are exposed to environmental toxicants." ..
  18. Role of CCK Receptor in Acute Pancreatitis Pathogenesis
    Isaac Samuel; Fiscal Year: 2007
    ..James W. Maher, MD, Director, Division of Gastrointestinal Surgery, University of Iowa College of Medicine, Iowa City. [] PHS 398/2590 (Rev. 05/01) Page__ 26 Continuation Format Page [] ..
  19. NOVEL USE OF ZEBRAFISH FOR APOPTOSIS ASSAY
    Chuenlei Parng; Fiscal Year: 2004
    ..Complementary visual and flow cytometry based assays will also be developed to provide comprehensive analysis of apoptosis in zebrafish. ..
  20. DIETARY LIPIDS AND EXPERIMENTAL IGA NEPHROPATHY
    James Pestka; Fiscal Year: 2009
    ..abstract_text> ..
  21. A Nanocrystal Biosensor for Detection of Multiple TBI Neurochemical Biomarkers
    Yongcheng Liu; Fiscal Year: 2007
    ..In comparison to existing technologies such as ELISA, this new technology will be more sensitive, reliable, specific, accurate, portable, robust, inexpensive and rapider to assess TBI. [unreadable] [unreadable] [unreadable]..
  22. Cardiotoxicity Drug Screening Using Zebrafish
    Chuenlei Parng; Fiscal Year: 2004
    ..Zebrafish drug screens can serve as an intermediate step between cell-based and mammalian testing, streamlining the drug development timeline. ..
  23. Role of Prohibitin in Mediating Suppression of Breast Cancer Growth by Estrogen *
    Sheng Wang; Fiscal Year: 2004
    ..abstract_text> ..
  24. DMBA DERVIVATIVES AND CHEMICAL CARCINOGENESIS
    JAMES FLESHER; Fiscal Year: 2002
    ..abstract_text> ..
  25. DIETARY NUTRIENTS AS MODULATORS OF HEPATIC METABOLISM
    Michael Pagliassotti; Fiscal Year: 2001
    ..Finally, to explain the decreased Km of G-6Pase for G6P during HS diet, and increased Vmax during HF diet, kinetics of this enzyme will be measured in the intact and disrupted microsomes. ..
  26. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  27. Caspase Mediated Diaphragmatic Dysfunction
    GERALD SUPINSKI; Fiscal Year: 2009
    ..These experiments will use both transgenic animal models and C2C12 cells to assess the effect of genetic and chemical inhibition of superoxide/nitric oxide on caspase responses. ..
  28. FREE RADICALS AND MUSCLE DYSFUNCTION IN HEART FAILURE
    GERALD SUPINSKI; Fiscal Year: 2005
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of heart failure-related skeletal muscle dysfunction. ..
  29. FACTORS RESPONSIBLE FOR THE CONTROL OF HUMAN LABOR
    ROGER YOUNG; Fiscal Year: 2003
    ....
  30. DIAPHRAGMATIC DYSFUNCTION IN SEPSIS
    GERALD SUPINSKI; Fiscal Year: 2001
    ..These data suggest that the proposed experiments should provide important information regarding the pathogenesis of sepsis-induced muscle dysfunction. ..
  31. MAPK/PKR Modulation of Diaphragm Weakness
    Gerald S Supinski; Fiscal Year: 2010
    ..We will both characterize the effects of inflammation on DISC formation, localization, and autocatalytic activity and determine if these alterations can be blocked by inhibition of p38, JNK, and/or PKR signaling pathways. ..
  32. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Yongcheng Liu; Fiscal Year: 2006
    ..3). produce CdS/CdSe/CdTe or CdS/CdTe/CdSe quantum well type-ll nanocrystals by SILAR and develop standard procedures. 4). develop dendron-nanocrystals and box-nanocrystals by chemical modification of these nanocrystals. ..