Genomes and Genes
aromatic polycyclic hydrocarbons
Summary: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Publications271 found, 100 shown here
- Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient airCarl Elis Boström
Swedish Environmental Protection Agency, Stockholm, Sweden
Environ Health Perspect 110:451-88. 2002..Additional source-specific indicators are benzo[ghi]perylene for gasoline vehicles, retene for wood combustion, and dibenzothiophene and benzonaphthothiophene for sulfur-containing fuels...
- Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of lifeWieslaw Jedrychowski
Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7 Kopernika Street, Krakow, Poland
Eur J Epidemiol 20:775-82. 2005....
- Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city childrenFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 114:1287-92. 2006..The results require confirmation but suggest that environmental PAHs at levels recently encountered in New York City air may adversely affect children's cognitive development at 3 years of age, with implications for school performance...
- Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohortRachel L Miller
Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA
Chest 126:1071-8. 2004..We also hypothesized that exposure to environmental tobacco smoke (ETS) may worsen symptoms beyond that observed to be associated with PAH alone...
- Long-term ecosystem response to the Exxon Valdez oil spillCharles H Peterson
University of North Carolina at Chapel Hill, Institute of Marine Sciences, Morehead City, NC 28557, USA
Science 302:2082-6. 2003..Delayed population reductions and cascades of indirect effects postponed recovery. Development of ecosystem-based toxicology is required to understand and ultimately predict chronic, delayed, and indirect long-term risks and impacts...
- Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of actionWilliam M Baird
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
Environ Mol Mutagen 45:106-14. 2005..Thus, PAHs may also act through a promotional mechanism in addition to serving as tumor initiators. Previous studies on these mechanisms are described and summarized...
- Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic populationFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Environ Health Perspect 111:201-5. 2003..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
- A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compoundsRoger W L Godschalk
Department of Health Risk Analysis and Toxicology, University of Maastricht, 6200 MD Maastricht, The Netherlands
J Biochem Mol Biol 36:1-11. 2003..Their use in risk-assessment, however, requires further investigation...
- Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbonsJohn P Incardona
Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, WA 98112, USA
Toxicol Appl Pharmacol 196:191-205. 2004..Therefore, different PAH compounds have distinct and specific effects on fish at early life history stages...
- Polycyclic aromatic hydrocarbon exposures of children in low-income familiesJ C Chuang
National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
J Expo Anal Environ Epidemiol 9:85-98. 1999..S. EPA's Integrated Risk System), most of which are of low volatility. The analysis of variance results showed that inner city participants had higher total exposure to B2 PAH than did rural participants...
- Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbonsTsutomu Shimada
Department of Chemical Biology, Osaka City University Medical School, Osaka, Japan
Drug Metab Pharmacokinet 21:257-76. 2006..Factors affecting such variations include induction and inhibition of enzymes by diverse chemicals and, more importantly, genetic polymorphisms of enzymes in humans...
- Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic populationFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue B 109, New York, NY 10032, USA
Environ Health Perspect 112:626-30. 2004..This study provides evidence that combined exposure to environmental pollutants at levels currently encountered in New York City adversely affects fetal development...
- Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methodsI G Kavouras
Environmental Science and Engineering Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
Environ Sci Technol 35:2288-94. 2001..The reconstructed concentrations of particle phase aliphatic and polynuclear aromatic hydrocarbons were in good agreement (R2 > 0.70) with those measured in Santiago de Chile...
- Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cellsAnita Solhaug
Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N 0403 Oslo, Norway
Carcinogenesis 25:809-19. 2004..In conclusion, B[a]P and the CP-PAH induced apoptotic as well as anti-apoptotic signals in Hepa1c1c7 cells...
- Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysisMonica Neri
Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
Mutat Res 612:14-39. 2006....
- Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodesF Donato
Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Igiene, Universita di Brescia, Via Valsabbina 19, 25123 Brescia, Italy
Occup Environ Med 57:484-7. 2000..To investigate the risk of cancer and non-neoplastic respiratory diseases among workers who manufacture carbon electrodes, as this industry entails exposure to mixtures of polycyclic aromatic hydrocarbons...
- Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthmaFrederica Perera
The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
PLoS ONE 4:e4488. 2009..The results support the emerging theory of early origins of later life disease development...
- Molecular epidemiologic research on the effects of environmental pollutants on the fetusF P Perera
Joseph L Mailman School of Public Health at Columbia University, New York, NY 10032, USA
Environ Health Perspect 107:451-60. 1999....
- A mortality study among workers in a French aluminium reduction plantJ J Moulin
Department of Epidemiology, Institut National de Recherche et de Securite, Vandoeuvre les Nancy, France
Int Arch Occup Environ Health 73:323-30. 2000..A mortality study on the association between lung cancer and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) was carried out in a French aluminium reduction plant. This study updated a previous mortality study...
- Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicityTian Xia
Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
Environ Health Perspect 112:1347-58. 2004..In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects. These results suggest that DEP and UFP effects on the PTP and Delta-Psi m are mediated by adsorbed chemicals rather than the particles themselves...
- The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcomeJ Dejmek
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
Environ Health Perspect 108:1159-64. 2000..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
- Ultrafine particulate pollutants induce oxidative stress and mitochondrial damageNing Li
Department of Medicine, University of California, Los Angeles, California 90095, USA
Environ Health Perspect 111:455-60. 2003..This may contribute to oxidative stress. Our studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria...
- The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymesJane Y C Ma
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 20:117-47. 2002..Together, these effects inhibit cell-mediated immunity toward infectious agents, exacerbate respiratory allergy, cause DNA damage, and under long-term exposure, induce the development of lung tumors...
- Role of quinones in toxicologyJ L Bolton
Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
Chem Res Toxicol 13:135-60. 2000..The evidence strongly suggests that the numerous mechanisms of quinone toxicity (i.e., alkylation vs oxidative stress) can be correlated with the known pathology of the parent compound(s)...
- Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a reviewWeiling Xue
Department of Environmental Health, University of Cincinnati Medical Center, 3223 Eden Avenue, Cincinnati, OH 45267 0056, USA
Toxicol Appl Pharmacol 206:73-93. 2005..The review emphasizes the chemical/biochemical reactions involved in the metabolic processes and the chemical structures of metabolites and DNA adducts...
- Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbonsLudek Blaha
Veterinary Research Institute, Hudcova 70, CZ 62132 Brno, Czech Republic
Toxicol Sci 65:43-51. 2002..0 (strongest inhibitors), suitable for the purposes of environmental risk assessment...
- Evaluation of fecal mutagenicity and colorectal cancer riskT M De Kok
Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD, Maastricht, Netherlands
Mutat Res 463:53-101. 2000..This knowledge will enable us to improve epidemiological study design and statistical power in future research...
- Determination of firefighter exposure to polycyclic aromatic hydrocarbons and benzene during fire fighting using measurement of biological indicatorsChantal Caux
Department of Environmental and Occupational Health, University of Montreal, Quebec, Canada
Appl Occup Environ Hyg 17:379-86. 2002..For both contaminants, observation of low exposure could be due to either low concentrations of the contaminant during fire fighting or to the efficiency of protective equipment worn...
- Molecular characterization and substrate preference of a polycyclic aromatic hydrocarbon dioxygenase from Cycloclasticus sp. strain A5Yuki Kasai
Marine Biotechnology Institute, Heita, Kamaishi, Iwate, Japan
Appl Environ Microbiol 69:6688-97. 2003..Significantly, the E. coli cells also transformed biphenyl and diphenylmethane, which are ordinarily the substrates of biphenyl dioxygenases...
- Persistent organic pollutants in the dusts that settled across lower Manhattan after September 11, 2001J H Offenberg
Department of Environmental Science, Rutgers The State University of New Jersey, 14 College Farm Road, New Brunswick, New Jersey 08901, USA
Environ Sci Technol 37:502-8. 2003..5 microm), often accounting for approximately 0.005% by mass. We estimate that approximately 100-1000 tons of sigma37-PAHs were spread over a localized area immediately after the WTC disaster on September 11...
- Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000-2001Blanka Binkova
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
Mutat Res 525:43-59. 2003..Therefore, high-quality monitoring data of carcinogenic PAHs may be useful for epidemiological studies of the impact of air pollution on the health of the population and for helping decision makers to improve our environment...
- Evaluation of fish early life-stage toxicity models of chronic embryonic exposures to complex polycyclic aromatic hydrocarbon mixturesMace G Barron
P E A K Research, 1130 Avon Lane, Longmont, Colorado 80501, USA
Toxicol Sci 78:60-7. 2004..We recommend the continued use of total PAHs as a metric of exposure until mechanistic models have been further evaluated...
- Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damageFrederica P Perera
Mailman School of Public Health of Columbia University, Department of Environmental Health Sciences, New York, New York 10032, USA
Environ Health Perspect 112:1133-6. 2004..The findings have implications for risk assessment, given the need to protect children as a sensitive subset of the population...
- Accumulation of endocrine disrupting compounds in sheep fetal and maternal liver tissue following exposure to pastures treated with sewage sludgeS M Rhind
Macaulay Institute, Craigiebuckler, Aberdeen, UK
J Environ Monit 11:1469-76. 2009..Differential accumulation of individual pollutants may have important implications for the assessment of risk from exposure...
- Liquid chromatography/atmospheric pressure ionization mass spectrometry with post-column liquid mixing for the efficient determination of partially oxidized polycyclic aromatic hydrocarbonsSylvia Grosse
Analytical Research Group, Chair of Biopolymer Chemistry, Department of Basic Life Sciences, Technical University of Munich, Freising Weihenstephan, Germany
J Chromatogr A 1139:75-83. 2007..Finally, the hyphenated system was applied to an exemplary aerosol extract and thus highlighting the expedient utilization of this downscaled method for real samples...
- Deleterious effects of polynuclear aromatic hydrocarbon on blood vascular system of the rat fetusMrinal K Sanyal
Department of Obstetrics and Gynecology, Yale University Medical School, New Haven, CT, USA
Birth Defects Res B Dev Reprod Toxicol 80:367-73. 2007..The relative deleterious effects of these agents on growth and blood vasculature of fetus and placental tissues of the rat were studied...
- Sources of polycyclic aromatic hydrocarbons (PAHs) in street dust in a tropical Asian mega-city, Bangkok, ThailandRuchaya Boonyatumanond
Environmental Research and Training Center ERTC, Pathumthani 12120, Thailand
Sci Total Environ 384:420-32. 2007..Multiple regression analysis of PAH profiles and diagnostics of hopane compositions identified tire debris as the major contributor of PAHs to street dust, followed by diesel vehicle exhaust...
- Validation and calibration of a model used to reconstruct historical exposure to polycyclic aromatic hydrocarbons for use in epidemiologic studiesJan Beyea
Consulting in the Public Interest, Lambertville, New Jersey, USA
Environ Health Perspect 114:1053-8. 2006..Here we report the results of four exercises to validate and calibrate the model...
- Biomarkers of genotoxicity of air pollution (the AULIS project): bulky DNA adducts in subjects with moderate to low exposures to airborne polycyclic aromatic hydrocarbons and their relationship to environmental tobacco smoke and other parametersP Georgiadis
National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
Carcinogenesis 22:1447-57. 2001..No significant effects were observed for other dietary parameters or factors reflecting exposure to air pollution...
- The contribution of particles washed from rooftops to contaminant loading to urban streamsP C Van Metre
US Geological Survey, Research and Investigations, 8027 Exchange Dr, Austin, TX 78754 3898, USA
Chemosphere 52:1727-41. 2003..The contribution from atmospheric deposition of particles onto rooftops to total watershed loads in stormwater was estimated to be greatest for mercury, contributing about 46 percent...
- Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological studyJudith C Chow
Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV, 89512, USA and Aerosol and Environmental Division, Institute of Earth Environment, Chinese Academy of Science, Xian, China corrected
J Environ Sci Health A Tox Hazard Subst Environ Eng 41:517-42. 2006..5 to 3.5 times during the coal-fired power plant operational period. However, further investigation is needed to determine the relative contribution from residential and utility coal combustion and vehicular activities...
- Isolation and characterization of Pseudoalteromonas strains with divergent polycyclic aromatic hydrocarbon catabolic propertiesBrian P Hedlund
Department of Biological Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, 89154 4004, USA
Environ Microbiol 8:178-82. 2006....
- Isolation, characterization, and polyaromatic hydrocarbon degradation potential of aerobic bacteria from marine macrofaunal burrow sediments and description of Lutibacterium anuloederans gen. nov., sp. nov., and Cycloclasticus spirillensus sp. novW K Chung
Darling Marine Center, University of Maine, Walpole 04573, USA
Appl Environ Microbiol 67:5585-92. 2001..In addition, only L. anuloederans appeared to enhance phenanthrene degradation in heavily contaminated sediment from Little Mystic Cove, Boston Harbor, Boston, Mass...
- Adsorption and absorption of polycyclic aromatic hydrocarbons to rice rootsX C Jiao
Laboratory for Earth Surface Processes, College of Environmental Sciences, Peking University, Beijing, China
Environ Pollut 148:230-5. 2007..Correlation analysis between bioconcentration factors (root over environment) and K(OA), K(OW) showed water to be more significant for PAH adsorption in rice roots than other environmental media...
- Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fishMace G Barron
P E A K Research, Longmont, Colorado, USA
Mar Environ Res 58:95-100. 2004..These results show that PAHs can have similar potency as many dioxin-like PCBs, and AhR mediated toxicity should be considered in assessing the risks of PAHs in fish...
- Resolution of GC-MS data of complex PAC mixtures and regression modeling of mutagenicity by PLSI Eide
Statoil Research Centre, N 7005 Trondheim, Norway, and Department of Chemistry, University of Bergen, N 5007 Bergen, Norway
Environ Sci Technol 35:2314-8. 2001..These variables covary with the observed mutagenicity, and may subsequently be identified chemically. Furthermore, the regression model can be used to predict mutagenicity from GC-MS chromatograms of other organic extracts...
- Occurrence of gaseous and particulate polycyclic aromatic hydrocarbons in the urban atmosphere: study of sources and ambient temperature effect on the gas/particle concentration and distributionManolis Tsapakis
Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, EL 71409 Heraklion, Greece
Environ Pollut 133:147-56. 2005..Shift in gas/particle distribution due to difference in ambient temperature elucidated to some extent the seasonal variation of the concentration of PAHs in particles...
- Estimate of oil persisting on the beaches of Prince William Sound 12 years after the Exxon Valdez oil spillJeffrey W Short
Auke Bay Laboratory, Alaska Fisheries Science Center, National Marine Fisheries Service, NOAA, 11305 Glacier Highway, Juneau, Alaska 99801 8626, USA
Environ Sci Technol 38:19-25. 2004....
- Polycyclic aromatic hydrocarbon degradation by a new marine bacterium, Neptunomonas naphthovorans gen. nov., sp. novB P Hedlund
Department of Microbiology, University of Washington, Seattle, Washington 98195 7274, USA
Appl Environ Microbiol 65:251-9. 1999..The type strain of N. naphthovorans is strain NAG-2N-126...
- Exposure to traffic emissions throughout life and risk of breast cancer: the Western New York Exposures and Breast Cancer (WEB) studyJing Nie
Department of Social and Preventive Medicine, School of Public Health and Health Professions, 270 Farber Hall, University at Buffalo, 3435 Main St, Buffalo, NY 14214, USA
Cancer Causes Control 18:947-55. 2007..In this study, we examined breast cancer risk in relation to exposure to air pollution from traffic emissions throughout life...
- Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution researchRalph J Delfino
Epidemiology Division, Department of Medicine, University of California, Irvine, California 92697 7550, USA
Environ Health Perspect 110:573-89. 2002..Community studies should focus on air toxics expected to have adverse respiratory effects based on biological mechanisms, particularly irritant and immunological pathways to asthma onset and exacerbation...
- Tobacco smoke carcinogens and breast cancerStephen S Hecht
University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
Environ Mol Mutagen 39:119-26. 2002..Collectively, the link between smoking and breast cancer is plausible but has been difficult to establish, probably because of the low carcinogen dose...
- Seasonal and annual variations in air concentrations of Pb, Cd and PAHs in Cairo, EgyptM A Hassanien
National Research Center, Environmental Protection Research Division, Air Research and Pollution Control Department, Dokki, Cairo, Egypt
Int J Environ Health Res 11:13-27. 2001..The levels of lead observed are higher than those recorded in various other parts of the world...
- Pollutants in house dust as indicators of indoor contaminationWerner Butte
University of Oldenburg, Faculty of Chemistry, Box 2503, D26111 Oldenburg, Germany
Rev Environ Contam Toxicol 175:1-46. 2002..It is justified to shift more attention to indoor pollution by house dust contamination and to improve the risk assessment of nondietary ingestion, but any health-based standard must be accompanied by a specific dust sampling method...
- Measurement of urinary monohydroxy polycyclic aromatic hydrocarbons using automated liquid-liquid extraction and gas chromatography/isotope dilution high-resolution mass spectrometryZheng Li
National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, F17, Atlanta, Georgia 30341, USA
Anal Chem 78:5744-51. 2006..This method is currently applied to epidemiological studies, such as the National Exposure and Nutrition Examination Survey (NHANES), to measure human exposure to PAHs...
- Genotoxicity of urban air pollutants in the Czech Republic. Part II. DNA adduct formation in mammalian cells by extractable organic matterJ Topinka
Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Mutat Res 469:83-93. 2000..The results, furthermore, indicate that analysis of DNA adducts in mammalian cells in culture offers a suitable method for monitoring the genotoxicity of complex mixtures of environmental chemicals...
- Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effectsNing Li
Department of Medicine Division of Clinical Immunology and Allergy, University of California, Los Angeles, CA 90095, USA
Clin Immunol 109:250-65. 2003..We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma...
- Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health studyD Tang
Division of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Cancer Res 61:6708-12. 2001..The findings are of interest because they suggest that individuals who become cases have greater biological susceptibility to tobacco carcinogens, a biological difference, which manifests most clearly while exposure is ongoing...
- Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stressJesus A Araujo
Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
Circ Res 102:589-96. 2008..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor...
- Tobacco smoke carcinogens and lung cancerS S Hecht
University of Minnesota Cancer Center, Minneapolis 55455, USA
J Natl Cancer Inst 91:1194-210. 1999..By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned...
- Health and environmental consequences of the world trade center disasterPhilip J Landrigan
Mount Sinai School of Medicine, New York, New York 10029, USA
Environ Health Perspect 112:731-9. 2004..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster...
- Polycyclic aromatic hydrocarbons in the indoor and outdoor air of three cities in the U.SYelena Y Naumova
Department of Environmental Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
Environ Sci Technol 36:2552-9. 2002....
- Polycyclic aromatic hydrocarbons (PAHs) in meat products and estimated PAH intake by children and the general population in EstoniaM Reinik
Estonian Health Protection Inspectorate, Tartu Laboratory, Tartu, Estonia
Food Addit Contam 24:429-37. 2007..5 microg kg(-1) in smoked chicken samples. Since smoking and grilling are prevalent meat-cooking methods in Estonia, the impact of meat products is assessed to be significant in overall PAH intake...
- Effect of petrochemical sludge concentrations of changes in mutagenic activity during soil bioremediation processI S Morelli
Laboratorio de Biodegradación Microbiológica de Hidrocarburos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
Environ Toxicol Chem 20:2179-83. 2001....
- International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growthHyunok Choi
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 114:1744-50. 2006..To address this gap in knowledge, we examined the association between prenatal exposure to airborne PAHs and birth weight, birth length, and birth head circumference, respectively, in Krakow, Poland, and New York City (NYC)...
- Elucidation of the metabolic pathway of fluorene and cometabolic pathways of phenanthrene, fluoranthene, anthracene and dibenzothiophene by Sphingomonas sp. LB126Rene Van Herwijnen
University of Amsterdam, Department of Environmental and Toxicological Chemistry IBED MTC, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
Res Microbiol 154:199-206. 2003....
- Degradation and formation of polycyclic aromatic compounds during bioslurry treatment of an aged gasworks soilStaffan Lundstedt
Environmental Chemistry, Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
Environ Toxicol Chem 22:1413-20. 2003..Because oxy-PAHs can be acutely toxic, mutagenic, or carcinogenic, we suggest that this group of compounds should also be monitored during the treatment of PAH-contaminated soil...
- Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measureMatthew R Bonner
Department of Social and Preventive Medicine, School of Public Health and Professions, University at Buffalo, Buffalo, NY, USA
Cancer Epidemiol Biomarkers Prev 14:53-60. 2005..Our study suggests that exposure in early life to high levels of PAHs may increase the risk of postmenopausal breast cancer; however, other confounders related to geography cannot be ruled out...
- Enrichment versus biofilm culture: a functional and phylogenetic comparison of polycyclic aromatic hydrocarbon-degrading microbial communitiesJames E M Stach
Research School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
Environ Microbiol 4:169-82. 2002..The study also indicated that cultivation of microbial communities on solid media might be the primary source of bias in the recovery of diverse species...
- Stress responses to polycyclic aromatic hydrocarbons in Arabidopsis include growth inhibition and hypersensitive response-like symptomsMerianne Alkio
Department of Biology and Department of Environmental, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
J Exp Bot 56:2983-94. 2005....
- PAHs underfoot: contaminated dust from coal-tar sealcoated pavement is widespread in the United StatesPeter C Van Metre
U S Geological Survey, Austin, Texas, USA
Environ Sci Technol 43:20-5. 2009..Concentrations of benzo[a]pyrene in dustfrom coal-tarsealcoated pavement and adjacent soils greatly exceed generic soil screening levels, suggesting that research on human-health risk is warranted...
- Activation of different pathways of apoptosis by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in cultureZeina Dagher
LCE EA2598, Toxicologie Industrielle et Environnementale, Maison de la Recherche en Environnement Industriel de Dunkerque 2, 189A, Avenue Maurice Schumann, 59140 Dunkerque, France
Toxicology 225:12-24. 2006..Taken together, these findings suggested that in vitro short-term exposure to PM(2.5) induced apoptosis in L132 cells...
- Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult femalesSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
J Expo Anal Environ Epidemiol 15:482-90. 2005..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking...
- Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at homeNancy K Wilson
Battelle Memorial Institute, Durham, NC 27713 4411, USA
J Expo Anal Environ Epidemiol 13:187-202. 2003..The children's potential aggregate doses, calculated from our data, were generally well below established reference doses (RfDs) for those compounds for which RfDs are available...
- Phytoremediation of polyaromatic hydrocarbons, anilines and phenolsPatricia J Harvey
University of Greenwich, School of Chemical and Life Sciences, Wellington Street, London SE18 6PF, UK
Environ Sci Pollut Res Int 9:29-47. 2002..In this regard, the application to harvested plants of composting techniques based on the degradative capacity of white-rot fungi merits attention...
- Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workersM D McClean
Harvard School of Public Health, Boston, MA 02115, USA
Ann Occup Hyg 48:565-78. 2004....
- In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluorantheneK L Willett
Department of Pharmacology and Environmental Toxicology Research Program, University of Mississippi, University, Mississippi 38677 1848, USA
Toxicol Appl Pharmacol 177:264-71. 2001..Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures...
- High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern IranFarin Kamangar
Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
Anticancer Res 25:425-8. 2005..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
- Cooked meat and risk of breast cancer--lifetime versus recent dietary intakeSusan E Steck
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Epidemiology 18:373-82. 2007..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature...
- The mutagenic hazards of settled house dust: a reviewRebecca M Maertens
Mutagenesis Section, Safe Environments Program, Health Canada, Tunney s Pasture 0803A, Ottawa, Ont, Canada K1A 0L2
Mutat Res 567:401-25. 2004..Analyses of SHD and its contaminants provide an indication of indoor pollution and present important information for human exposure assessments...
- Mutagens in contaminated soil: a reviewPaul A White
Mutagenesis Section, Safe Environments Program, Health Canada, Tunney s Pasture 0803A, Ottawa, Ont, Canada K1A 0L2
Mutat Res 567:227-345. 2004..Despite substantial contamination and mutagenic hazards, the risk of adverse effect (e.g., mutation, cancer) in humans or terrestrial biota is difficult to quantify...
- Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbonsAyumi Kasai
Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
Anal Biochem 337:84-8. 2005..Because of its time-saving property and easiness, sensitiveness, and specificity, the fast-track DRESSA would be advantageous for high-throughput screening of dioxin and dioxin-like compounds in environmental samples...
- The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseasesHesham M Korashy
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Drug Metab Rev 38:411-50. 2006....
- Toxic effects and oxidative stress in higher plants exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivativesVeronika Paková
RECETOX Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
Environ Toxicol Chem 25:3238-45. 2006....
- Fate of atmospherically deposited polycyclic aromatic hydrocarbons (PAHs) in Chesapeake BayK M Arzayus
School of Marine Science/Virginia Institute of Marine Science, College of William and Mary, P.O. Box 1346, Route 1208, Gloucester Point, Virginia 23062, USA
Environ Sci Technol 35:2178-83. 2001..The fate of PAHs input to the Bay from gas deposition was determined to be uptake and metabolism within the aquatic food web rather than deposition to sediments...
- DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and ChinaFrederica Perera
Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Columbia Center for Children s Environmental Health, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:709-14. 2005..The data support preventive policies to limit PAH exposure to pregnant women and children...
- Identification of a novel metabolite in the degradation of pyrene by Mycobacterium sp. strain AP1: actions of the isolate on two- and three-ring polycyclic aromatic hydrocarbonsJ Vila
Department of Microbiology, University of Barcelona, Barcelona, Spain
Appl Environ Microbiol 67:5497-505. 2001....
- Performance of the partition-limited model on predicting ryegrass uptake of polycyclic aromatic hydrocarbonsZhenya Yang
Department of Environmental Science, Zhejiang University, Hangzhou 310028, China
Chemosphere 67:402-9. 2007..Results from this study substantiated the utility of this partition-limited model for vegetation-uptake assessment, and then provided some testimony valuable for the modification of a model with a better performance...
- Dissolved oxygen saturation controls PAH biodegradation in freshwater estuary sedimentsT J Boyd
Code 6114, U S Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA
Microb Ecol 49:226-35. 2005..Infusion of cooler, well-oxygenated water to the water column overlying contaminated sediments during the summer months may stimulate PAH metabolism preferentially over non-PAH organic matter...
- Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growthFrederica P Perera
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
Environ Health Perspect 113:1062-7. 2005..04). The findings suggest that exposure to elevated levels of PAHs, indicated by PAH-DNA adducts in cord blood, may have contributed to reduced fetal growth in women exposed to the WTC event...
- Fluoranthene metabolism in Mycobacterium sp. strain KR20: identity of pathway intermediates during degradation and growthK Rehmann
GSF National Research Center for Environment and Health, Institute of Ecological Chemistry, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
Microbiology 147:2783-94. 2001..Besides fluoranthene, the isolate could not use any of the PAHs tested as a sole source of carbon and energy...
- Isolation and characterization of bacteria capable of degrading polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides from PAH-contaminated soil in Hilo, HawaiiJong Su Seo
Department of Molecular Biosciences and Bioengineering, University of Hawaii, 1955 East West Road, Honolulu, Hawaii 96822, USA
J Agric Food Chem 55:5383-9. 2007..P1-1 can degrade carbofenothion, chlorfenvinphos, diazinon, fonofos, and pirimiphos-methyl. JS14 can transform chlorfenvinphos and diazinon. JS19b1 can break down diazinon, pirimiphos-methyl, and temephos...
- Genotoxicity is unrelated to total concentration of priority carcinogenic polycyclic aromatic hydrocarbons in soils undergoing biological treatmentRenee R Alexander
Department of Crop and Soil Sciences and Institute for Comparative and Environmental Toxicology, Cornell Univ, Ithaca, NY 14853, USA
J Environ Qual 31:150-4. 2002..The data show that genotoxicity of contaminated soils may be unrelated to the concentration of carcinogenic PAHs because of aging or new mutagens formed during biological treatment...
- Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbonsA Besaratinia
Department of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010 3000, USA
Biomarkers 7:209-29. 2002..The salient findings are highlighted, the uncertainties are underlined and, finally, recommendations for future research are made...
- Uptake of selected PAHs from contaminated soils by rice seedlings (Oryza sativa) and influence of rhizosphere on PAH distributionYu Hong Su
Chemistry Department, Xinjiang University, Urumqi 830046, China
Environ Pollut 155:359-65. 2008..24 and 14%, respectively, based on PYR concentrations in rhizosphere and non-rhizosphere soils, the biomass of rice roots, and the dry soil weight...
- Metabolite repression inhibits degradation of benzo[a]pyrene and dibenz[a,h]anthracene by Stenotrophomonas maltophilia VUN 10,003A L Juhasz
Centre for Bioprocessing and Food Technology, Victoria University of Technology, Melbourne City, Melbourne, Australia
J Ind Microbiol Biotechnol 28:88-96. 2002..Metabolite or by-product repression was suspected to be responsible for the inhibition: By-products from the degradation of the five-ring compounds inhibited their further degradation...
- Early childhood lower respiratory illness and air pollutionIrva Hertz-Picciotto
Department of Public Health Sciences, University of California, Davis, California 95616, USA
Environ Health Perspect 115:1510-8. 2007..Few studies of air pollutants address morbidity in preschool children. In this study we evaluated bronchitis in children from two Czech districts: Teplice, with high ambient air pollution, and Prachatice, characterized by lower exposures...
- Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophagesNing Li
Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
J Immunol 169:4531-41. 2002..Moreover, epithelial cells are not able to convert N-acetylcysteine to cytoprotective glutathione...
- Real-Time PCR quantification of PAH-ring hydroxylating dioxygenase (PAH-RHDalpha) genes from Gram positive and Gram negative bacteria in soil and sediment samplesAurélie Cébron
Laboratoire des Interactions Microorganismes Minéraux Matière Organique dans les Sols UMR7137, Nancy Universite, CNRS, Faculte des Sciences, B P 239, 54506 Vandoeuvre les Nancy Cedex, France
J Microbiol Methods 73:148-59. 2008..This ratio highlighted a positive correlation between the PAH-bacterial biodegradation potential and the PAH-contamination level in the environmental samples studied...
- Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York CityCathryn C Tonne
Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
Environ Health Perspect 112:754-9. 2004..This is the largest study to date characterizing personal exposures to PAHs, a ubiquitous class of carcinogenic air contaminants in urban environments, and is unique in its focus on pregnant minority women...
- Incomplete degradation of polycyclic aromatic hydrocarbons in soil inoculated with wood-rotting fungi and their effect on the indigenous soil bacteriaB Erik Andersson
Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE 221 00 Lund, Sweden
Environ Toxicol Chem 22:1238-43. 2003..In the soil inoculated with A. vaillantii, on the other hand, no metabolites accumulated, and no negative effects were observed on the indigenous microorganisms...
- BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANTFrederica Perera; Fiscal Year: 2001..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
- VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.Frederica Perera; Fiscal Year: 2004....
- CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTSStephen S Hecht; Fiscal Year: 2010..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
- METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINESStephen Hecht; Fiscal Year: 2003..abstract_text> ..
- Lung Cancer Chemoprevention: Isothiocyanates, inositolStephen Hecht; Fiscal Year: 2008..abstract_text> ..
- Tobacco CarcinogenesisStephen Hecht; Fiscal Year: 2005..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
- Admixture Mapping of Sarcoidosis Genes in African AmericanBenjamin Rybicki; Fiscal Year: 2007..Our proposed study has the potential to uncover genes of modest effect not easily detectable by linkage and may in some instances actually be more statistically powerful than traditional case-control association methods. ..
- Telomere dysfunction, oxidative damage and breast cancer riskJing Shen; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- ISEA 2004 ConferenceJunfeng Zhang; Fiscal Year: 2004..abstract_text> ..
- CYCLIN D1 AS BIOMARKER OF BREAST CANCER RISKDeliang Tang; Fiscal Year: 2001..Once validated, this biomarker could be useful in the early detection, management and follow up of breast cancer. ..
- Prenatal diesel exposure and adult onset asthmaRachel Miller; Fiscal Year: 2006..Aim 4: Determine a) the differential gene expression following in utero diesel exposure, and b) whether differential gene expression following prenatal diesel exposure is associated with adult asthma. [unreadable] [unreadable]..
- Pediatric Asthma, Particulate Air Pollution and NO2RALPH DELFINO; Fiscal Year: 2006..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
- Early Childhood Development and PCB Exposures in Slovak*Irva Hertz Picciotto; Fiscal Year: 2005..Other unique features include the evaluation of hearing loss at birth, the measurement of hydroxy and methylsulfone metabolites of PCBs, and a population which includes about 1/3 Gypsies. ..
- Predictors of Spatial Patterns in Urban Air PollutionJonathan Levy; Fiscal Year: 2006..unreadable] [unreadable]..
- International Society Environmental Epidemiology 2003Irva Hertz Picciotto; Fiscal Year: 2003..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. ..
- ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUTRALPH DELFINO; Fiscal Year: 2001..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
- INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGERachel Miller; Fiscal Year: 2002..Both the memory allergic response to antigenic stimulation and the polyclonal IgE response will be studied. In addition, the components of the memory response that are affected by Stat6 activity will be analyzed. (End of Abstract) ..
- Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment RemediationUpal Ghosh; Fiscal Year: 2009..This field research will evaluate the effectiveness of a novel approach to alter the binding capacity of sediments to reduce human exposure to such contaminants. ..
- Sequence Effects of Arylamine-DNA Adducts: Repair and ReplicationBONGSUP CHO; Fiscal Year: 2008..Such knowledge will also be of help in the development of sensible prevention and risk assessment strategies. ..
- Data Coordinating Center for Sleep Heart HealthMarie Diener West; Fiscal Year: 2007..abstract_text> ..
- Gene-Nutrient Interactions and Breast CancerSUSAN STECK; Fiscal Year: 2007..abstract_text> ..
- Roles of CYP1 & 19 in Fundulus Steroids & PAH MetabolismKristine Willett; Fiscal Year: 2009..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
- Early Determinants of Mammographic DensityMary Beth Terry; Fiscal Year: 2009..abstract_text> ..
- Phase I/II Trial of ZD1839 and Celecoxib in Ex-SmokersMichael Kelley; Fiscal Year: 2006..abstract_text> ..
- Function and Regulation of Human Cytochrome P4502S1Oliver Hankinson; Fiscal Year: 2010....
- Health Effects of the London Congestion Charge SchemeCathryn Tonne; Fiscal Year: 2008..The proposed research would provide useful insight into the potential of such traffic management strategies as important public health interventions. ..
- Chemoprevention of colon cancer via neonatal imprintingAramandla Ramesh; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Linking Breast Cancer Advocacy and Environmental JusticeJulia Brody; Fiscal Year: 2008....
- CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLSOliver Hankinson; Fiscal Year: 2010..abstract_text> ..
- Molecular Epidemiology of Pancreatic CancerDonghui Li; Fiscal Year: 2008..Such information will be valuable for the primary prevention of this deadly disease. ..
- Isomeric HRT estrogen-DNA adducts: Structure and RepairNicholas Geacintov; Fiscal Year: 2009..abstract_text> ..
- Characterization of MBD3L1 and MBD3L2GERD PFEIFER; Fiscal Year: 2008..Since both proteins are likely functioning as transcriptional regulators, it will be important to determine if there are changes in gene expression patterns in Mbd311 and Mbd312 (-/-) cells. ..
- Ultra-Low Dose Carcinogen Testing with the Trout ModelDavid Williams; Fiscal Year: 2009..abstract_text> ..
- Method Development for the Analysis of PBDEs in Human Placenta TissueAn Li; Fiscal Year: 2008..A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born. [unreadable] [unreadable] [unreadable]..
- Impact of Environmental Pollutants on Breast Cancer and*Julia Brody; Fiscal Year: 2005..abstract_text> ..
- Micromass LCT Mass SpectrometerMICHAEL CRIMMINS; Fiscal Year: 2004..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
- Chemoprevention in Mice after Tobacco Smoke ExposureHanspeter Witschi; Fiscal Year: 2004..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
- REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHSKENNETH LAALI; Fiscal Year: 2004..DNA binding and mammalian cell mutagenicity studies on the substituted and derivatized-PAHs proposed for stable ion work will enhance the available literature data on structure/reactivity relationships. ..
- Detection of Pathogens in Avian Fecal PollutionSANDRA MCLELLAN; Fiscal Year: 2003..abstract_text> ..
- Validation of biomarkers of prenatal pesticides exposureRobin Whyatt; Fiscal Year: 2003....
- Implications of Genomics Research on Racial DefinitionSeymour Garte; Fiscal Year: 2003..A new paradigm of gene-specific variation will be developed for a biomedically useful method of division of the human population into groups based on criteria different from current definitions of race. ..
- Measurement of Hypoxia in Non Small Cell Lung CarcinomaMichael Kelley; Fiscal Year: 2003..We believe the data from this pilot study will be useful to design future study(ies) with clinical endpoints and to guide selection of subjects for novel hypoxia-directed therapies in patients with NSCLC...
- Dietary fat modulated metabolic fate of fluorantheneAramandla Ramesh; Fiscal Year: 2003..abstract_text> ..
- FT-IR/GC-MS MODELS FOR PREDICTING PROSTATE CANCERDONALD MALINS; Fiscal Year: 2002..At the conclusion of these studies we expect to have significantly increased understanding of the etiology of prostate cancer and established a promising basis for cancer prediction. ..
- DNA BASE SEQUENCE EFFECTS IN CHEMICAL CARCINOGENESISNicholas Geacintov; Fiscal Year: 2002....
- Quantifying Biosynthesized Porphyrins and ComplexesMARK SCHLAUTMAN; Fiscal Year: 2004..The CL detection systems developed for ion-pair HPLC in this project will ultimately find use as powerful new detection systems for micro-chip, nano-chip, and microarray applications. ..
- Risk Factors for Ductal Carcinoma In Situ (DCIS)Julia Brody; Fiscal Year: 2004..The study builds on the Cape Cod Breast Cancer and Environment Study of invasive breast cancer and additional grants that currently support the proposed study of DCIS. ..
- MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTERDavid Williams; Fiscal Year: 2006..abstract_text> ..
- A Computational Docking Resource for Cancer ResearchArthur Olson; Fiscal Year: 2006..Formal training workshops will provide training on the most popular modeling and simulation methods to the wider NCI community. This Resource will both accelerate and extend research in Cancer Biology for the NCI community. ..
- ARNT:Roles in Tumor Induction and Growth, and Toxicity.Oliver Hankinson; Fiscal Year: 2006..abstract_text> ..
- ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTSMICHAEL CRIMMINS; Fiscal Year: 2006..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
- Early Determinants of Breast Cancer RiskMary Beth Terry; Fiscal Year: 2006..abstract_text> ..
- DNA Damage as Women Age: Implications for Breast CancerDONALD MALINS; Fiscal Year: 2005....
- MODIFIERS OF CARCINOGENESIS--ENVIRONMENTAL PAH MIXTURESWilliam Baird; Fiscal Year: 2005..This will aid in the development of methods for predicting the relative carcinogenic potency based upon the PAH composition of complex environmental mixtures. ..
- RASSF1 Tumor Suppressor GeneGERD PFEIFER; Fiscal Year: 2005..The effect of RASSF1 expression on RAS signaling pathways will be studied. We will examine if RASSF1A, alone or in combination with activated RAS, induces cell death (apoptosis). ..
- EVALUATING EXPOSURES UNDER OSHAS 1984 ETO STANDARDRobert Herrick; Fiscal Year: 2001..abstract_text> ..
- Breast Cancer Prevention and Treatment with Noni juiceMian Ying Wang; Fiscal Year: 2007..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
- Synthesis of Novel Anticancer AgentsMARISA KOZLOWSKI; Fiscal Year: 2007..Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented. ..
- Designing Asymmetric Ligands Using Computational TechniquesMARISA KOZLOWSKI; Fiscal Year: 2009..The current proposal will create or retain four jobs. ..