aromatic polycyclic hydrocarbons

Summary

Summary: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)

Top Publications

  1. pmc Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    Carl Elis Boström
    Swedish Environmental Protection Agency, Stockholm, Sweden
    Environ Health Perspect 110:451-88. 2002
  2. ncbi Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7 Kopernika Street, Krakow, Poland
    Eur J Epidemiol 20:775-82. 2005
  3. pmc Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1287-92. 2006
  4. pmc Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort
    Rachel L Miller
    Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA
    Chest 126:1071-8. 2004
  5. ncbi Long-term ecosystem response to the Exxon Valdez oil spill
    Charles H Peterson
    University of North Carolina at Chapel Hill, Institute of Marine Sciences, Morehead City, NC 28557, USA
    Science 302:2082-6. 2003
  6. ncbi Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action
    William M Baird
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Environ Mol Mutagen 45:106-14. 2005
  7. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
  8. ncbi A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds
    Roger W L Godschalk
    Department of Health Risk Analysis and Toxicology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biochem Mol Biol 36:1-11. 2003
  9. ncbi Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons
    John P Incardona
    Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, WA 98112, USA
    Toxicol Appl Pharmacol 196:191-205. 2004
  10. ncbi Polycyclic aromatic hydrocarbon exposures of children in low-income families
    J C Chuang
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Expo Anal Environ Epidemiol 9:85-98. 1999

Research Grants

  1. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
  2. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
  3. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
  4. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
  5. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
  6. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
  7. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin Rybicki; Fiscal Year: 2007
  8. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
  9. ISEA 2004 Conference
    Junfeng Zhang; Fiscal Year: 2004
  10. CYCLIN D1 AS BIOMARKER OF BREAST CANCER RISK
    Deliang Tang; Fiscal Year: 2001

Detail Information

Publications271 found, 100 shown here

  1. pmc Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    Carl Elis Boström
    Swedish Environmental Protection Agency, Stockholm, Sweden
    Environ Health Perspect 110:451-88. 2002
    ..Additional source-specific indicators are benzo[ghi]perylene for gasoline vehicles, retene for wood combustion, and dibenzothiophene and benzonaphthothiophene for sulfur-containing fuels...
  2. ncbi Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life
    Wieslaw Jedrychowski
    Epidemiology and Preventive Medicine, Jagiellonian University Medical College, 7 Kopernika Street, Krakow, Poland
    Eur J Epidemiol 20:775-82. 2005
    ....
  3. pmc Effect of prenatal exposure to airborne polycyclic aromatic hydrocarbons on neurodevelopment in the first 3 years of life among inner-city children
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1287-92. 2006
    ..The results require confirmation but suggest that environmental PAHs at levels recently encountered in New York City air may adversely affect children's cognitive development at 3 years of age, with implications for school performance...
  4. pmc Polycyclic aromatic hydrocarbons, environmental tobacco smoke, and respiratory symptoms in an inner-city birth cohort
    Rachel L Miller
    Division of Pulmonary, Allergy, Critical Care Medicine, Department of Medicine, Columbia University College of Physicians and Surgeons, PH8C, 630 168th Street, New York, NY 10032, USA
    Chest 126:1071-8. 2004
    ..We also hypothesized that exposure to environmental tobacco smoke (ETS) may worsen symptoms beyond that observed to be associated with PAH alone...
  5. ncbi Long-term ecosystem response to the Exxon Valdez oil spill
    Charles H Peterson
    University of North Carolina at Chapel Hill, Institute of Marine Sciences, Morehead City, NC 28557, USA
    Science 302:2082-6. 2003
    ..Delayed population reductions and cascades of indirect effects postponed recovery. Development of ecosystem-based toxicology is required to understand and ultimately predict chronic, delayed, and indirect long-term risks and impacts...
  6. ncbi Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of action
    William M Baird
    Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA
    Environ Mol Mutagen 45:106-14. 2005
    ..Thus, PAHs may also act through a promotional mechanism in addition to serving as tumor initiators. Previous studies on these mechanisms are described and summarized...
  7. pmc Effects of transplacental exposure to environmental pollutants on birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
    Environ Health Perspect 111:201-5. 2003
    ..This study provides evidence that environmental pollutants at levels currently encountered in New York City adversely affect fetal development...
  8. ncbi A critical evaluation of DNA adducts as biological markers for human exposure to polycyclic aromatic compounds
    Roger W L Godschalk
    Department of Health Risk Analysis and Toxicology, University of Maastricht, 6200 MD Maastricht, The Netherlands
    J Biochem Mol Biol 36:1-11. 2003
    ..Their use in risk-assessment, however, requires further investigation...
  9. ncbi Defects in cardiac function precede morphological abnormalities in fish embryos exposed to polycyclic aromatic hydrocarbons
    John P Incardona
    Environmental Conservation Division, Northwest Fisheries Science Center, National Oceanic and Atmospheric Administration, Seattle, WA 98112, USA
    Toxicol Appl Pharmacol 196:191-205. 2004
    ..Therefore, different PAH compounds have distinct and specific effects on fish at early life history stages...
  10. ncbi Polycyclic aromatic hydrocarbon exposures of children in low-income families
    J C Chuang
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    J Expo Anal Environ Epidemiol 9:85-98. 1999
    ..S. EPA's Integrated Risk System), most of which are of low volatility. The analysis of variance results showed that inner city participants had higher total exposure to B2 PAH than did rural participants...
  11. ncbi Xenobiotic-metabolizing enzymes involved in activation and detoxification of carcinogenic polycyclic aromatic hydrocarbons
    Tsutomu Shimada
    Department of Chemical Biology, Osaka City University Medical School, Osaka, Japan
    Drug Metab Pharmacokinet 21:257-76. 2006
    ..Factors affecting such variations include induction and inhibition of enzymes by diverse chemicals and, more importantly, genetic polymorphisms of enzymes in humans...
  12. pmc Molecular evidence of an interaction between prenatal environmental exposures and birth outcomes in a multiethnic population
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, 60 Haven Avenue B 109, New York, NY 10032, USA
    Environ Health Perspect 112:626-30. 2004
    ..This study provides evidence that combined exposure to environmental pollutants at levels currently encountered in New York City adversely affects fetal development...
  13. ncbi Source apportionment of urban particulate aliphatic and polynuclear aromatic hydrocarbons (PAHs) using multivariate methods
    I G Kavouras
    Environmental Science and Engineering Program, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA
    Environ Sci Technol 35:2288-94. 2001
    ..The reconstructed concentrations of particle phase aliphatic and polynuclear aromatic hydrocarbons were in good agreement (R2 > 0.70) with those measured in Santiago de Chile...
  14. ncbi Polycyclic aromatic hydrocarbons induce both apoptotic and anti-apoptotic signals in Hepa1c1c7 cells
    Anita Solhaug
    Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, N 0403 Oslo, Norway
    Carcinogenesis 25:809-19. 2004
    ..In conclusion, B[a]P and the CP-PAH induced apoptotic as well as anti-apoptotic signals in Hepa1c1c7 cells...
  15. ncbi Children's exposure to environmental pollutants and biomarkers of genetic damage. II. Results of a comprehensive literature search and meta-analysis
    Monica Neri
    Unit of Epidemiology and Biostatistics, Department of Epidemiology and Prevention, National Cancer Research Institute, Largo Rosanna Benzi, 10, 16132 Genoa, Italy
    Mutat Res 612:14-39. 2006
    ....
  16. pmc Mortality from cancer and chronic respiratory diseases among workers who manufacture carbon electrodes
    F Donato
    Dipartimento di Medicina Sperimentale ed Applicata, Sezione di Igiene, Universita di Brescia, Via Valsabbina 19, 25123 Brescia, Italy
    Occup Environ Med 57:484-7. 2000
    ..To investigate the risk of cancer and non-neoplastic respiratory diseases among workers who manufacture carbon electrodes, as this industry entails exposure to mixtures of polycyclic aromatic hydrocarbons...
  17. pmc Relation of DNA methylation of 5'-CpG island of ACSL3 to transplacental exposure to airborne polycyclic aromatic hydrocarbons and childhood asthma
    Frederica Perera
    The Columbia Center for Children s Environmental Health, Columbia University Mailman School of Public Health, New York, New York, United States of America
    PLoS ONE 4:e4488. 2009
    ..The results support the emerging theory of early origins of later life disease development...
  18. pmc Molecular epidemiologic research on the effects of environmental pollutants on the fetus
    F P Perera
    Joseph L Mailman School of Public Health at Columbia University, New York, NY 10032, USA
    Environ Health Perspect 107:451-60. 1999
    ....
  19. ncbi A mortality study among workers in a French aluminium reduction plant
    J J Moulin
    Department of Epidemiology, Institut National de Recherche et de Securite, Vandoeuvre les Nancy, France
    Int Arch Occup Environ Health 73:323-30. 2000
    ..A mortality study on the association between lung cancer and occupational exposure to polycyclic aromatic hydrocarbons (PAHs) was carried out in a French aluminium reduction plant. This study updated a previous mortality study...
  20. pmc Quinones and aromatic chemical compounds in particulate matter induce mitochondrial dysfunction: implications for ultrafine particle toxicity
    Tian Xia
    Division of Clinical Immunology and Allergy, Department of Medicine, UCLA School of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1680, USA
    Environ Health Perspect 112:1347-58. 2004
    ..In contrast, commercial polystyrene nanoparticles failed to exert mitochondrial effects. These results suggest that DEP and UFP effects on the PTP and Delta-Psi m are mediated by adsorbed chemicals rather than the particles themselves...
  21. pmc The impact of polycyclic aromatic hydrocarbons and fine particles on pregnancy outcome
    J Dejmek
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Science of the Czech Republic, Prague, Czech Republic
    Environ Health Perspect 108:1159-64. 2000
    ..The results prove that exposure to c-PAHs in early gestation may influence fetal growth. The particulate matter-IUGR association observed earlier may be at least partly explained by the presence of c-PAHs on particle surfaces...
  22. pmc Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage
    Ning Li
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Environ Health Perspect 111:455-60. 2003
    ..This may contribute to oxidative stress. Our studies demonstrate that the increased biological potency of UFPs is related to the content of redox cycling organic chemicals and their ability to damage mitochondria...
  23. ncbi The dual effect of the particulate and organic components of diesel exhaust particles on the alteration of pulmonary immune/inflammatory responses and metabolic enzymes
    Jane Y C Ma
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 20:117-47. 2002
    ..Together, these effects inhibit cell-mediated immunity toward infectious agents, exacerbate respiratory allergy, cause DNA damage, and under long-term exposure, induce the development of lung tumors...
  24. ncbi Role of quinones in toxicology
    J L Bolton
    Department of Medicinal Chemistry and Pharmacognosy M C 781, College of Pharmacy, The University of Illinois at Chicago, 833 South Wood Street, Chicago, Illinois 60612 7231, USA
    Chem Res Toxicol 13:135-60. 2000
    ..The evidence strongly suggests that the numerous mechanisms of quinone toxicity (i.e., alkylation vs oxidative stress) can be correlated with the known pathology of the parent compound(s)...
  25. ncbi Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: a review
    Weiling Xue
    Department of Environmental Health, University of Cincinnati Medical Center, 3223 Eden Avenue, Cincinnati, OH 45267 0056, USA
    Toxicol Appl Pharmacol 206:73-93. 2005
    ..The review emphasizes the chemical/biochemical reactions involved in the metabolic processes and the chemical structures of metabolites and DNA adducts...
  26. ncbi Inhibition of gap-junctional intercellular communication by environmentally occurring polycyclic aromatic hydrocarbons
    Ludek Blaha
    Veterinary Research Institute, Hudcova 70, CZ 62132 Brno, Czech Republic
    Toxicol Sci 65:43-51. 2002
    ..0 (strongest inhibitors), suitable for the purposes of environmental risk assessment...
  27. ncbi Evaluation of fecal mutagenicity and colorectal cancer risk
    T M De Kok
    Department of Health Risk Analysis and Toxicology, University of Maastricht, PO Box 616, 6200 MD, Maastricht, Netherlands
    Mutat Res 463:53-101. 2000
    ..This knowledge will enable us to improve epidemiological study design and statistical power in future research...
  28. ncbi Determination of firefighter exposure to polycyclic aromatic hydrocarbons and benzene during fire fighting using measurement of biological indicators
    Chantal Caux
    Department of Environmental and Occupational Health, University of Montreal, Quebec, Canada
    Appl Occup Environ Hyg 17:379-86. 2002
    ..For both contaminants, observation of low exposure could be due to either low concentrations of the contaminant during fire fighting or to the efficiency of protective equipment worn...
  29. pmc Molecular characterization and substrate preference of a polycyclic aromatic hydrocarbon dioxygenase from Cycloclasticus sp. strain A5
    Yuki Kasai
    Marine Biotechnology Institute, Heita, Kamaishi, Iwate, Japan
    Appl Environ Microbiol 69:6688-97. 2003
    ..Significantly, the E. coli cells also transformed biphenyl and diphenylmethane, which are ordinarily the substrates of biphenyl dioxygenases...
  30. ncbi Persistent organic pollutants in the dusts that settled across lower Manhattan after September 11, 2001
    J H Offenberg
    Department of Environmental Science, Rutgers The State University of New Jersey, 14 College Farm Road, New Brunswick, New Jersey 08901, USA
    Environ Sci Technol 37:502-8. 2003
    ..5 microm), often accounting for approximately 0.005% by mass. We estimate that approximately 100-1000 tons of sigma37-PAHs were spread over a localized area immediately after the WTC disaster on September 11...
  31. ncbi Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000-2001
    Blanka Binkova
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, Prague 4, Czech Republic
    Mutat Res 525:43-59. 2003
    ..Therefore, high-quality monitoring data of carcinogenic PAHs may be useful for epidemiological studies of the impact of air pollution on the health of the population and for helping decision makers to improve our environment...
  32. ncbi Evaluation of fish early life-stage toxicity models of chronic embryonic exposures to complex polycyclic aromatic hydrocarbon mixtures
    Mace G Barron
    P E A K Research, 1130 Avon Lane, Longmont, Colorado 80501, USA
    Toxicol Sci 78:60-7. 2004
    ..We recommend the continued use of total PAHs as a metric of exposure until mechanistic models have been further evaluated...
  33. pmc Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage
    Frederica P Perera
    Mailman School of Public Health of Columbia University, Department of Environmental Health Sciences, New York, New York 10032, USA
    Environ Health Perspect 112:1133-6. 2004
    ..The findings have implications for risk assessment, given the need to protect children as a sensitive subset of the population...
  34. ncbi Accumulation of endocrine disrupting compounds in sheep fetal and maternal liver tissue following exposure to pastures treated with sewage sludge
    S M Rhind
    Macaulay Institute, Craigiebuckler, Aberdeen, UK
    J Environ Monit 11:1469-76. 2009
    ..Differential accumulation of individual pollutants may have important implications for the assessment of risk from exposure...
  35. ncbi Liquid chromatography/atmospheric pressure ionization mass spectrometry with post-column liquid mixing for the efficient determination of partially oxidized polycyclic aromatic hydrocarbons
    Sylvia Grosse
    Analytical Research Group, Chair of Biopolymer Chemistry, Department of Basic Life Sciences, Technical University of Munich, Freising Weihenstephan, Germany
    J Chromatogr A 1139:75-83. 2007
    ..Finally, the hyphenated system was applied to an exemplary aerosol extract and thus highlighting the expedient utilization of this downscaled method for real samples...
  36. ncbi Deleterious effects of polynuclear aromatic hydrocarbon on blood vascular system of the rat fetus
    Mrinal K Sanyal
    Department of Obstetrics and Gynecology, Yale University Medical School, New Haven, CT, USA
    Birth Defects Res B Dev Reprod Toxicol 80:367-73. 2007
    ..The relative deleterious effects of these agents on growth and blood vasculature of fetus and placental tissues of the rat were studied...
  37. ncbi Sources of polycyclic aromatic hydrocarbons (PAHs) in street dust in a tropical Asian mega-city, Bangkok, Thailand
    Ruchaya Boonyatumanond
    Environmental Research and Training Center ERTC, Pathumthani 12120, Thailand
    Sci Total Environ 384:420-32. 2007
    ..Multiple regression analysis of PAH profiles and diagnostics of hopane compositions identified tire debris as the major contributor of PAHs to street dust, followed by diesel vehicle exhaust...
  38. pmc Validation and calibration of a model used to reconstruct historical exposure to polycyclic aromatic hydrocarbons for use in epidemiologic studies
    Jan Beyea
    Consulting in the Public Interest, Lambertville, New Jersey, USA
    Environ Health Perspect 114:1053-8. 2006
    ..Here we report the results of four exercises to validate and calibrate the model...
  39. ncbi Biomarkers of genotoxicity of air pollution (the AULIS project): bulky DNA adducts in subjects with moderate to low exposures to airborne polycyclic aromatic hydrocarbons and their relationship to environmental tobacco smoke and other parameters
    P Georgiadis
    National Hellenic Research Foundation, Institute of Biological Research and Biotechnology, 48 Vassileos Constantinou Avenue, Athens 11635, Greece
    Carcinogenesis 22:1447-57. 2001
    ..No significant effects were observed for other dietary parameters or factors reflecting exposure to air pollution...
  40. ncbi The contribution of particles washed from rooftops to contaminant loading to urban streams
    P C Van Metre
    US Geological Survey, Research and Investigations, 8027 Exchange Dr, Austin, TX 78754 3898, USA
    Chemosphere 52:1727-41. 2003
    ..The contribution from atmospheric deposition of particles onto rooftops to total watershed loads in stormwater was estimated to be greatest for mercury, contributing about 46 percent...
  41. ncbi Exposure to PM2.5 and PAHs from the Tong Liang, China epidemiological study
    Judith C Chow
    Division of Atmospheric Sciences, Desert Research Institute, 2215 Raggio Parkway, Reno, NV, 89512, USA and Aerosol and Environmental Division, Institute of Earth Environment, Chinese Academy of Science, Xian, China corrected
    J Environ Sci Health A Tox Hazard Subst Environ Eng 41:517-42. 2006
    ..5 to 3.5 times during the coal-fired power plant operational period. However, further investigation is needed to determine the relative contribution from residential and utility coal combustion and vehicular activities...
  42. ncbi Isolation and characterization of Pseudoalteromonas strains with divergent polycyclic aromatic hydrocarbon catabolic properties
    Brian P Hedlund
    Department of Biological Sciences, University of Nevada, Las Vegas, 4505 Maryland Parkway, 89154 4004, USA
    Environ Microbiol 8:178-82. 2006
    ....
  43. pmc Isolation, characterization, and polyaromatic hydrocarbon degradation potential of aerobic bacteria from marine macrofaunal burrow sediments and description of Lutibacterium anuloederans gen. nov., sp. nov., and Cycloclasticus spirillensus sp. nov
    W K Chung
    Darling Marine Center, University of Maine, Walpole 04573, USA
    Appl Environ Microbiol 67:5585-92. 2001
    ..In addition, only L. anuloederans appeared to enhance phenanthrene degradation in heavily contaminated sediment from Little Mystic Cove, Boston Harbor, Boston, Mass...
  44. ncbi Adsorption and absorption of polycyclic aromatic hydrocarbons to rice roots
    X C Jiao
    Laboratory for Earth Surface Processes, College of Environmental Sciences, Peking University, Beijing, China
    Environ Pollut 148:230-5. 2007
    ..Correlation analysis between bioconcentration factors (root over environment) and K(OA), K(OW) showed water to be more significant for PAH adsorption in rice roots than other environmental media...
  45. ncbi Relative potency of PAHs and heterocycles as aryl hydrocarbon receptor agonists in fish
    Mace G Barron
    P E A K Research, Longmont, Colorado, USA
    Mar Environ Res 58:95-100. 2004
    ..These results show that PAHs can have similar potency as many dioxin-like PCBs, and AhR mediated toxicity should be considered in assessing the risks of PAHs in fish...
  46. ncbi Resolution of GC-MS data of complex PAC mixtures and regression modeling of mutagenicity by PLS
    I Eide
    Statoil Research Centre, N 7005 Trondheim, Norway, and Department of Chemistry, University of Bergen, N 5007 Bergen, Norway
    Environ Sci Technol 35:2314-8. 2001
    ..These variables covary with the observed mutagenicity, and may subsequently be identified chemically. Furthermore, the regression model can be used to predict mutagenicity from GC-MS chromatograms of other organic extracts...
  47. ncbi Occurrence of gaseous and particulate polycyclic aromatic hydrocarbons in the urban atmosphere: study of sources and ambient temperature effect on the gas/particle concentration and distribution
    Manolis Tsapakis
    Environmental Chemical Processes Laboratory, Department of Chemistry, University of Crete, EL 71409 Heraklion, Greece
    Environ Pollut 133:147-56. 2005
    ..Shift in gas/particle distribution due to difference in ambient temperature elucidated to some extent the seasonal variation of the concentration of PAHs in particles...
  48. ncbi Estimate of oil persisting on the beaches of Prince William Sound 12 years after the Exxon Valdez oil spill
    Jeffrey W Short
    Auke Bay Laboratory, Alaska Fisheries Science Center, National Marine Fisheries Service, NOAA, 11305 Glacier Highway, Juneau, Alaska 99801 8626, USA
    Environ Sci Technol 38:19-25. 2004
    ....
  49. pmc Polycyclic aromatic hydrocarbon degradation by a new marine bacterium, Neptunomonas naphthovorans gen. nov., sp. nov
    B P Hedlund
    Department of Microbiology, University of Washington, Seattle, Washington 98195 7274, USA
    Appl Environ Microbiol 65:251-9. 1999
    ..The type strain of N. naphthovorans is strain NAG-2N-126...
  50. ncbi Exposure to traffic emissions throughout life and risk of breast cancer: the Western New York Exposures and Breast Cancer (WEB) study
    Jing Nie
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, 270 Farber Hall, University at Buffalo, 3435 Main St, Buffalo, NY 14214, USA
    Cancer Causes Control 18:947-55. 2007
    ..In this study, we examined breast cancer risk in relation to exposure to air pollution from traffic emissions throughout life...
  51. pmc Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research
    Ralph J Delfino
    Epidemiology Division, Department of Medicine, University of California, Irvine, California 92697 7550, USA
    Environ Health Perspect 110:573-89. 2002
    ..Community studies should focus on air toxics expected to have adverse respiratory effects based on biological mechanisms, particularly irritant and immunological pathways to asthma onset and exacerbation...
  52. ncbi Tobacco smoke carcinogens and breast cancer
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Environ Mol Mutagen 39:119-26. 2002
    ..Collectively, the link between smoking and breast cancer is plausible but has been difficult to establish, probably because of the low carcinogen dose...
  53. ncbi Seasonal and annual variations in air concentrations of Pb, Cd and PAHs in Cairo, Egypt
    M A Hassanien
    National Research Center, Environmental Protection Research Division, Air Research and Pollution Control Department, Dokki, Cairo, Egypt
    Int J Environ Health Res 11:13-27. 2001
    ..The levels of lead observed are higher than those recorded in various other parts of the world...
  54. ncbi Pollutants in house dust as indicators of indoor contamination
    Werner Butte
    University of Oldenburg, Faculty of Chemistry, Box 2503, D26111 Oldenburg, Germany
    Rev Environ Contam Toxicol 175:1-46. 2002
    ..It is justified to shift more attention to indoor pollution by house dust contamination and to improve the risk assessment of nondietary ingestion, but any health-based standard must be accompanied by a specific dust sampling method...
  55. ncbi Measurement of urinary monohydroxy polycyclic aromatic hydrocarbons using automated liquid-liquid extraction and gas chromatography/isotope dilution high-resolution mass spectrometry
    Zheng Li
    National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Highway, F17, Atlanta, Georgia 30341, USA
    Anal Chem 78:5744-51. 2006
    ..This method is currently applied to epidemiological studies, such as the National Exposure and Nutrition Examination Survey (NHANES), to measure human exposure to PAHs...
  56. ncbi Genotoxicity of urban air pollutants in the Czech Republic. Part II. DNA adduct formation in mammalian cells by extractable organic matter
    J Topinka
    Laboratory of Genetic Ecotoxicology, Regional Institute of Hygiene of Central Bohemia and Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Mutat Res 469:83-93. 2000
    ..The results, furthermore, indicate that analysis of DNA adducts in mammalian cells in culture offers a suitable method for monitoring the genotoxicity of complex mixtures of environmental chemicals...
  57. ncbi Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects
    Ning Li
    Department of Medicine Division of Clinical Immunology and Allergy, University of California, Los Angeles, CA 90095, USA
    Clin Immunol 109:250-65. 2003
    ..We review the biology of oxidative stress, including protective and injurious effects that explain the impact of particulate matter-induced oxidative stress in asthma...
  58. ncbi Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study
    D Tang
    Division of Environmental Health Sciences, Joseph L. Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Cancer Res 61:6708-12. 2001
    ..The findings are of interest because they suggest that individuals who become cases have greater biological susceptibility to tobacco carcinogens, a biological difference, which manifests most clearly while exposure is ongoing...
  59. pmc Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress
    Jesus A Araujo
    Department of Medicine, David Geffen School of Medicine, 10833 Le Conte Ave, CHS 52 175, Box 951680, Los Angeles, CA 90095, USA
    Circ Res 102:589-96. 2008
    ..We conclude that ultrafine particles concentrate the proatherogenic effects of ambient PM and may constitute a significant cardiovascular risk factor...
  60. ncbi Tobacco smoke carcinogens and lung cancer
    S S Hecht
    University of Minnesota Cancer Center, Minneapolis 55455, USA
    J Natl Cancer Inst 91:1194-210. 1999
    ..By focusing in this review on several important carcinogens in tobacco smoke, the complexities in understanding tobacco-induced cancer can be reduced, and new approaches for lung cancer prevention can be envisioned...
  61. pmc Health and environmental consequences of the world trade center disaster
    Philip J Landrigan
    Mount Sinai School of Medicine, New York, New York 10029, USA
    Environ Health Perspect 112:731-9. 2004
    ..Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster...
  62. ncbi Polycyclic aromatic hydrocarbons in the indoor and outdoor air of three cities in the U.S
    Yelena Y Naumova
    Department of Environmental Sciences, Rutgers University, New Brunswick, New Jersey 08901, USA
    Environ Sci Technol 36:2552-9. 2002
    ....
  63. ncbi Polycyclic aromatic hydrocarbons (PAHs) in meat products and estimated PAH intake by children and the general population in Estonia
    M Reinik
    Estonian Health Protection Inspectorate, Tartu Laboratory, Tartu, Estonia
    Food Addit Contam 24:429-37. 2007
    ..5 microg kg(-1) in smoked chicken samples. Since smoking and grilling are prevalent meat-cooking methods in Estonia, the impact of meat products is assessed to be significant in overall PAH intake...
  64. ncbi Effect of petrochemical sludge concentrations of changes in mutagenic activity during soil bioremediation process
    I S Morelli
    Laboratorio de Biodegradación Microbiológica de Hidrocarburos, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina
    Environ Toxicol Chem 20:2179-83. 2001
    ....
  65. pmc International studies of prenatal exposure to polycyclic aromatic hydrocarbons and fetal growth
    Hyunok Choi
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 114:1744-50. 2006
    ..To address this gap in knowledge, we examined the association between prenatal exposure to airborne PAHs and birth weight, birth length, and birth head circumference, respectively, in Krakow, Poland, and New York City (NYC)...
  66. ncbi Elucidation of the metabolic pathway of fluorene and cometabolic pathways of phenanthrene, fluoranthene, anthracene and dibenzothiophene by Sphingomonas sp. LB126
    Rene Van Herwijnen
    University of Amsterdam, Department of Environmental and Toxicological Chemistry IBED MTC, Nieuwe Achtergracht 166, 1018WV Amsterdam, The Netherlands
    Res Microbiol 154:199-206. 2003
    ....
  67. ncbi Degradation and formation of polycyclic aromatic compounds during bioslurry treatment of an aged gasworks soil
    Staffan Lundstedt
    Environmental Chemistry, Department of Chemistry, Umea University, SE 901 87 Umea, Sweden
    Environ Toxicol Chem 22:1413-20. 2003
    ..Because oxy-PAHs can be acutely toxic, mutagenic, or carcinogenic, we suggest that this group of compounds should also be monitored during the treatment of PAH-contaminated soil...
  68. ncbi Breast cancer risk and exposure in early life to polycyclic aromatic hydrocarbons using total suspended particulates as a proxy measure
    Matthew R Bonner
    Department of Social and Preventive Medicine, School of Public Health and Professions, University at Buffalo, Buffalo, NY, USA
    Cancer Epidemiol Biomarkers Prev 14:53-60. 2005
    ..Our study suggests that exposure in early life to high levels of PAHs may increase the risk of postmenopausal breast cancer; however, other confounders related to geography cannot be ruled out...
  69. ncbi Enrichment versus biofilm culture: a functional and phylogenetic comparison of polycyclic aromatic hydrocarbon-degrading microbial communities
    James E M Stach
    Research School of Biosciences, University of Kent, Canterbury CT2 7NJ, UK
    Environ Microbiol 4:169-82. 2002
    ..The study also indicated that cultivation of microbial communities on solid media might be the primary source of bias in the recovery of diverse species...
  70. ncbi Stress responses to polycyclic aromatic hydrocarbons in Arabidopsis include growth inhibition and hypersensitive response-like symptoms
    Merianne Alkio
    Department of Biology and Department of Environmental, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125, USA
    J Exp Bot 56:2983-94. 2005
    ....
  71. ncbi PAHs underfoot: contaminated dust from coal-tar sealcoated pavement is widespread in the United States
    Peter C Van Metre
    U S Geological Survey, Austin, Texas, USA
    Environ Sci Technol 43:20-5. 2009
    ..Concentrations of benzo[a]pyrene in dustfrom coal-tarsealcoated pavement and adjacent soils greatly exceed generic soil screening levels, suggesting that research on human-health risk is warranted...
  72. ncbi Activation of different pathways of apoptosis by air pollution particulate matter (PM2.5) in human epithelial lung cells (L132) in culture
    Zeina Dagher
    LCE EA2598, Toxicologie Industrielle et Environnementale, Maison de la Recherche en Environnement Industriel de Dunkerque 2, 189A, Avenue Maurice Schumann, 59140 Dunkerque, France
    Toxicology 225:12-24. 2006
    ..Taken together, these findings suggested that in vitro short-term exposure to PM(2.5) induced apoptosis in L132 cells...
  73. ncbi Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult females
    Sumitra Shantakumar
    Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
    J Expo Anal Environ Epidemiol 15:482-90. 2005
    ..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking...
  74. ncbi Aggregate exposures of nine preschool children to persistent organic pollutants at day care and at home
    Nancy K Wilson
    Battelle Memorial Institute, Durham, NC 27713 4411, USA
    J Expo Anal Environ Epidemiol 13:187-202. 2003
    ..The children's potential aggregate doses, calculated from our data, were generally well below established reference doses (RfDs) for those compounds for which RfDs are available...
  75. ncbi Phytoremediation of polyaromatic hydrocarbons, anilines and phenols
    Patricia J Harvey
    University of Greenwich, School of Chemical and Life Sciences, Wellington Street, London SE18 6PF, UK
    Environ Sci Pollut Res Int 9:29-47. 2002
    ..In this regard, the application to harvested plants of composting techniques based on the degradative capacity of white-rot fungi merits attention...
  76. ncbi Urinary 1-hydroxypyrene and polycyclic aromatic hydrocarbon exposure among asphalt paving workers
    M D McClean
    Harvard School of Public Health, Boston, MA 02115, USA
    Ann Occup Hyg 48:565-78. 2004
    ....
  77. ncbi In vivo and in vitro inhibition of CYP1A-dependent activity in Fundulus heteroclitus by the polynuclear aromatic hydrocarbon fluoranthene
    K L Willett
    Department of Pharmacology and Environmental Toxicology Research Program, University of Mississippi, University, Mississippi 38677 1848, USA
    Toxicol Appl Pharmacol 177:264-71. 2001
    ..Because FL and perhaps other inhibitory PAHs, co-occur in the environment with CYP1A inducers, CYP1A-dependent bioassays may cause an underestimation of PAH exposures...
  78. ncbi High exposure to polycyclic aromatic hydrocarbons may contribute to high risk of esophageal cancer in northeastern Iran
    Farin Kamangar
    Cancer Prevention Studies Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 21218, USA
    Anticancer Res 25:425-8. 2005
    ..The northeastern region of Iran has some of the highest rates of esophageal squamous cell carcinoma (ESCC) in the world...
  79. ncbi Cooked meat and risk of breast cancer--lifetime versus recent dietary intake
    Susan E Steck
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
    Epidemiology 18:373-82. 2007
    ..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature...
  80. ncbi The mutagenic hazards of settled house dust: a review
    Rebecca M Maertens
    Mutagenesis Section, Safe Environments Program, Health Canada, Tunney s Pasture 0803A, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 567:401-25. 2004
    ..Analyses of SHD and its contaminants provide an indication of indoor pollution and present important information for human exposure assessments...
  81. ncbi Mutagens in contaminated soil: a review
    Paul A White
    Mutagenesis Section, Safe Environments Program, Health Canada, Tunney s Pasture 0803A, Ottawa, Ont, Canada K1A 0L2
    Mutat Res 567:227-345. 2004
    ..Despite substantial contamination and mutagenic hazards, the risk of adverse effect (e.g., mutation, cancer) in humans or terrestrial biota is difficult to quantify...
  82. ncbi Fast-track DRESSA: a bioassay for fast, sensitive, and selective detection of halogenated and polycyclic aromatic hydrocarbons
    Ayumi Kasai
    Department of Biochemistry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
    Anal Biochem 337:84-8. 2005
    ..Because of its time-saving property and easiness, sensitiveness, and specificity, the fast-track DRESSA would be advantageous for high-throughput screening of dioxin and dioxin-like compounds in environmental samples...
  83. ncbi The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases
    Hesham M Korashy
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Drug Metab Rev 38:411-50. 2006
    ....
  84. ncbi Toxic effects and oxidative stress in higher plants exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivatives
    Veronika Paková
    RECETOX Research Centre for Environmental Chemistry and Ecotoxicology, Masaryk University, Kamenice 3, CZ 625 00 Brno, Czech Republic
    Environ Toxicol Chem 25:3238-45. 2006
    ....
  85. ncbi Fate of atmospherically deposited polycyclic aromatic hydrocarbons (PAHs) in Chesapeake Bay
    K M Arzayus
    School of Marine Science/Virginia Institute of Marine Science, College of William and Mary, P.O. Box 1346, Route 1208, Gloucester Point, Virginia 23062, USA
    Environ Sci Technol 35:2178-83. 2001
    ..The fate of PAHs input to the Bay from gas deposition was determined to be uptake and metabolism within the aquatic food web rather than deposition to sediments...
  86. ncbi DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China
    Frederica Perera
    Department of Environmental Health Sciences, Mailman School of Public Health of Columbia University, Columbia Center for Children s Environmental Health, New York, NY 10032, USA
    Cancer Epidemiol Biomarkers Prev 14:709-14. 2005
    ..The data support preventive policies to limit PAH exposure to pregnant women and children...
  87. pmc Identification of a novel metabolite in the degradation of pyrene by Mycobacterium sp. strain AP1: actions of the isolate on two- and three-ring polycyclic aromatic hydrocarbons
    J Vila
    Department of Microbiology, University of Barcelona, Barcelona, Spain
    Appl Environ Microbiol 67:5497-505. 2001
    ....
  88. ncbi Performance of the partition-limited model on predicting ryegrass uptake of polycyclic aromatic hydrocarbons
    Zhenya Yang
    Department of Environmental Science, Zhejiang University, Hangzhou 310028, China
    Chemosphere 67:402-9. 2007
    ..Results from this study substantiated the utility of this partition-limited model for vegetation-uptake assessment, and then provided some testimony valuable for the modification of a model with a better performance...
  89. ncbi Dissolved oxygen saturation controls PAH biodegradation in freshwater estuary sediments
    T J Boyd
    Code 6114, U S Naval Research Laboratory, 4555 Overlook Ave, Washington, DC 20375, USA
    Microb Ecol 49:226-35. 2005
    ..Infusion of cooler, well-oxygenated water to the water column overlying contaminated sediments during the summer months may stimulate PAH metabolism preferentially over non-PAH organic matter...
  90. pmc Relationships among polycyclic aromatic hydrocarbon-DNA adducts, proximity to the World Trade Center, and effects on fetal growth
    Frederica P Perera
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York 10032, USA
    Environ Health Perspect 113:1062-7. 2005
    ..04). The findings suggest that exposure to elevated levels of PAHs, indicated by PAH-DNA adducts in cord blood, may have contributed to reduced fetal growth in women exposed to the WTC event...
  91. ncbi Fluoranthene metabolism in Mycobacterium sp. strain KR20: identity of pathway intermediates during degradation and growth
    K Rehmann
    GSF National Research Center for Environment and Health, Institute of Ecological Chemistry, Ingolstadter Landstrasse 1, D 85764 Neuherberg, Germany
    Microbiology 147:2783-94. 2001
    ..Besides fluoranthene, the isolate could not use any of the PAHs tested as a sole source of carbon and energy...
  92. ncbi Isolation and characterization of bacteria capable of degrading polycyclic aromatic hydrocarbons (PAHs) and organophosphorus pesticides from PAH-contaminated soil in Hilo, Hawaii
    Jong Su Seo
    Department of Molecular Biosciences and Bioengineering, University of Hawaii, 1955 East West Road, Honolulu, Hawaii 96822, USA
    J Agric Food Chem 55:5383-9. 2007
    ..P1-1 can degrade carbofenothion, chlorfenvinphos, diazinon, fonofos, and pirimiphos-methyl. JS14 can transform chlorfenvinphos and diazinon. JS19b1 can break down diazinon, pirimiphos-methyl, and temephos...
  93. ncbi Genotoxicity is unrelated to total concentration of priority carcinogenic polycyclic aromatic hydrocarbons in soils undergoing biological treatment
    Renee R Alexander
    Department of Crop and Soil Sciences and Institute for Comparative and Environmental Toxicology, Cornell Univ, Ithaca, NY 14853, USA
    J Environ Qual 31:150-4. 2002
    ..The data show that genotoxicity of contaminated soils may be unrelated to the concentration of carcinogenic PAHs because of aging or new mutagens formed during biological treatment...
  94. ncbi Biomonitoring of tobacco smoke carcinogenicity by dosimetry of DNA adducts and genotyping and phenotyping of biotransformational enzymes: a review on polycyclic aromatic hydrocarbons
    A Besaratinia
    Department of Biology, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, CA 91010 3000, USA
    Biomarkers 7:209-29. 2002
    ..The salient findings are highlighted, the uncertainties are underlined and, finally, recommendations for future research are made...
  95. ncbi Uptake of selected PAHs from contaminated soils by rice seedlings (Oryza sativa) and influence of rhizosphere on PAH distribution
    Yu Hong Su
    Chemistry Department, Xinjiang University, Urumqi 830046, China
    Environ Pollut 155:359-65. 2008
    ..24 and 14%, respectively, based on PYR concentrations in rhizosphere and non-rhizosphere soils, the biomass of rice roots, and the dry soil weight...
  96. ncbi Metabolite repression inhibits degradation of benzo[a]pyrene and dibenz[a,h]anthracene by Stenotrophomonas maltophilia VUN 10,003
    A L Juhasz
    Centre for Bioprocessing and Food Technology, Victoria University of Technology, Melbourne City, Melbourne, Australia
    J Ind Microbiol Biotechnol 28:88-96. 2002
    ..Metabolite or by-product repression was suspected to be responsible for the inhibition: By-products from the degradation of the five-ring compounds inhibited their further degradation...
  97. pmc Early childhood lower respiratory illness and air pollution
    Irva Hertz-Picciotto
    Department of Public Health Sciences, University of California, Davis, California 95616, USA
    Environ Health Perspect 115:1510-8. 2007
    ..Few studies of air pollutants address morbidity in preschool children. In this study we evaluated bronchitis in children from two Czech districts: Teplice, with high ambient air pollution, and Prachatice, characterized by lower exposures...
  98. ncbi Comparison of the pro-oxidative and proinflammatory effects of organic diesel exhaust particle chemicals in bronchial epithelial cells and macrophages
    Ning Li
    Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    J Immunol 169:4531-41. 2002
    ..Moreover, epithelial cells are not able to convert N-acetylcysteine to cytoprotective glutathione...
  99. ncbi Real-Time PCR quantification of PAH-ring hydroxylating dioxygenase (PAH-RHDalpha) genes from Gram positive and Gram negative bacteria in soil and sediment samples
    Aurélie Cébron
    Laboratoire des Interactions Microorganismes Minéraux Matière Organique dans les Sols UMR7137, Nancy Universite, CNRS, Faculte des Sciences, B P 239, 54506 Vandoeuvre les Nancy Cedex, France
    J Microbiol Methods 73:148-59. 2008
    ..This ratio highlighted a positive correlation between the PAH-bacterial biodegradation potential and the PAH-contamination level in the environmental samples studied...
  100. pmc Predictors of personal polycyclic aromatic hydrocarbon exposures among pregnant minority women in New York City
    Cathryn C Tonne
    Columbia Center for Children s Environmental Health, Mailman School of Public Health, Columbia University, New York, New York, USA
    Environ Health Perspect 112:754-9. 2004
    ..This is the largest study to date characterizing personal exposures to PAHs, a ubiquitous class of carcinogenic air contaminants in urban environments, and is unique in its focus on pregnant minority women...
  101. ncbi Incomplete degradation of polycyclic aromatic hydrocarbons in soil inoculated with wood-rotting fungi and their effect on the indigenous soil bacteria
    B Erik Andersson
    Department of Biotechnology, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE 221 00 Lund, Sweden
    Environ Toxicol Chem 22:1238-43. 2003
    ..In the soil inoculated with A. vaillantii, on the other hand, no metabolites accumulated, and no negative effects were observed on the indigenous microorganisms...

Research Grants62

  1. BIOMARKERS OF GENETIC DAMAGE AND ANTIOXIDANT
    Frederica Perera; Fiscal Year: 2001
    ..Once validated in this model population, these biomarkers would also have applicability in evaluating interventions in occupational cohorts and other populations highly exposed to carcinogens. ..
  2. VULNERABILITY OF THE FETUS/INFANT TO PAH, PM2.5 AND ETS.
    Frederica Perera; Fiscal Year: 2004
    ....
  3. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  4. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  5. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  6. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  7. Admixture Mapping of Sarcoidosis Genes in African American
    Benjamin Rybicki; Fiscal Year: 2007
    ..Our proposed study has the potential to uncover genes of modest effect not easily detectable by linkage and may in some instances actually be more statistically powerful than traditional case-control association methods. ..
  8. Telomere dysfunction, oxidative damage and breast cancer risk
    Jing Shen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. ISEA 2004 Conference
    Junfeng Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  10. CYCLIN D1 AS BIOMARKER OF BREAST CANCER RISK
    Deliang Tang; Fiscal Year: 2001
    ..Once validated, this biomarker could be useful in the early detection, management and follow up of breast cancer. ..
  11. Prenatal diesel exposure and adult onset asthma
    Rachel Miller; Fiscal Year: 2006
    ..Aim 4: Determine a) the differential gene expression following in utero diesel exposure, and b) whether differential gene expression following prenatal diesel exposure is associated with adult asthma. [unreadable] [unreadable]..
  12. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  13. Early Childhood Development and PCB Exposures in Slovak*
    Irva Hertz Picciotto; Fiscal Year: 2005
    ..Other unique features include the evaluation of hearing loss at birth, the measurement of hydroxy and methylsulfone metabolites of PCBs, and a population which includes about 1/3 Gypsies. ..
  14. Predictors of Spatial Patterns in Urban Air Pollution
    Jonathan Levy; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  15. International Society Environmental Epidemiology 2003
    Irva Hertz Picciotto; Fiscal Year: 2003
    ..ISEE provides a variety of forums for discussion, critical reviews, collaborations and education issues for environmental exposures and their human health effects. ..
  16. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  17. INDUCIBLE DOMINANT NEGATIVE OF STAT 6 IN MEMORY IGE
    Rachel Miller; Fiscal Year: 2002
    ..Both the memory allergic response to antigenic stimulation and the polyclonal IgE response will be studied. In addition, the components of the memory response that are affected by Stat6 activity will be analyzed. (End of Abstract) ..
  18. Pilot-scale Research of Novel Amendment Delivery for in-situ Sediment Remediation
    Upal Ghosh; Fiscal Year: 2009
    ..This field research will evaluate the effectiveness of a novel approach to alter the binding capacity of sediments to reduce human exposure to such contaminants. ..
  19. Sequence Effects of Arylamine-DNA Adducts: Repair and Replication
    BONGSUP CHO; Fiscal Year: 2008
    ..Such knowledge will also be of help in the development of sensible prevention and risk assessment strategies. ..
  20. Data Coordinating Center for Sleep Heart Health
    Marie Diener West; Fiscal Year: 2007
    ..abstract_text> ..
  21. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  22. Roles of CYP1 & 19 in Fundulus Steroids & PAH Metabolism
    Kristine Willett; Fiscal Year: 2009
    ..This research will further define the utility of Fundulus as a model organism for studying PAH-associated toxicities and in the development of human CYP19 or CYP1 B-related therapeutics. ..
  23. Early Determinants of Mammographic Density
    Mary Beth Terry; Fiscal Year: 2009
    ..abstract_text> ..
  24. Phase I/II Trial of ZD1839 and Celecoxib in Ex-Smokers
    Michael Kelley; Fiscal Year: 2006
    ..abstract_text> ..
  25. Function and Regulation of Human Cytochrome P4502S1
    Oliver Hankinson; Fiscal Year: 2010
    ....
  26. Health Effects of the London Congestion Charge Scheme
    Cathryn Tonne; Fiscal Year: 2008
    ..The proposed research would provide useful insight into the potential of such traffic management strategies as important public health interventions. ..
  27. Chemoprevention of colon cancer via neonatal imprinting
    Aramandla Ramesh; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Linking Breast Cancer Advocacy and Environmental Justice
    Julia Brody; Fiscal Year: 2008
    ....
  29. CARCINOGEN ACTIVATION AND SCREENING IN VARIANT CELLS
    Oliver Hankinson; Fiscal Year: 2010
    ..abstract_text> ..
  30. Molecular Epidemiology of Pancreatic Cancer
    Donghui Li; Fiscal Year: 2008
    ..Such information will be valuable for the primary prevention of this deadly disease. ..
  31. Isomeric HRT estrogen-DNA adducts: Structure and Repair
    Nicholas Geacintov; Fiscal Year: 2009
    ..abstract_text> ..
  32. Characterization of MBD3L1 and MBD3L2
    GERD PFEIFER; Fiscal Year: 2008
    ..Since both proteins are likely functioning as transcriptional regulators, it will be important to determine if there are changes in gene expression patterns in Mbd311 and Mbd312 (-/-) cells. ..
  33. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..abstract_text> ..
  34. Method Development for the Analysis of PBDEs in Human Placenta Tissue
    An Li; Fiscal Year: 2008
    ..A laboratory procedure is to be developed in order to understand how a wide-spread environmental pollutant affects the health of human fetus before babies are born. [unreadable] [unreadable] [unreadable]..
  35. Impact of Environmental Pollutants on Breast Cancer and*
    Julia Brody; Fiscal Year: 2005
    ..abstract_text> ..
  36. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  37. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  38. REACTIVE INTERMEDIATES OF CARCINOGENESIS OF PAHS
    KENNETH LAALI; Fiscal Year: 2004
    ..DNA binding and mammalian cell mutagenicity studies on the substituted and derivatized-PAHs proposed for stable ion work will enhance the available literature data on structure/reactivity relationships. ..
  39. Detection of Pathogens in Avian Fecal Pollution
    SANDRA MCLELLAN; Fiscal Year: 2003
    ..abstract_text> ..
  40. Validation of biomarkers of prenatal pesticides exposure
    Robin Whyatt; Fiscal Year: 2003
    ....
  41. Implications of Genomics Research on Racial Definition
    Seymour Garte; Fiscal Year: 2003
    ..A new paradigm of gene-specific variation will be developed for a biomedically useful method of division of the human population into groups based on criteria different from current definitions of race. ..
  42. Measurement of Hypoxia in Non Small Cell Lung Carcinoma
    Michael Kelley; Fiscal Year: 2003
    ..We believe the data from this pilot study will be useful to design future study(ies) with clinical endpoints and to guide selection of subjects for novel hypoxia-directed therapies in patients with NSCLC...
  43. Dietary fat modulated metabolic fate of fluoranthene
    Aramandla Ramesh; Fiscal Year: 2003
    ..abstract_text> ..
  44. FT-IR/GC-MS MODELS FOR PREDICTING PROSTATE CANCER
    DONALD MALINS; Fiscal Year: 2002
    ..At the conclusion of these studies we expect to have significantly increased understanding of the etiology of prostate cancer and established a promising basis for cancer prediction. ..
  45. DNA BASE SEQUENCE EFFECTS IN CHEMICAL CARCINOGENESIS
    Nicholas Geacintov; Fiscal Year: 2002
    ....
  46. Quantifying Biosynthesized Porphyrins and Complexes
    MARK SCHLAUTMAN; Fiscal Year: 2004
    ..The CL detection systems developed for ion-pair HPLC in this project will ultimately find use as powerful new detection systems for micro-chip, nano-chip, and microarray applications. ..
  47. Risk Factors for Ductal Carcinoma In Situ (DCIS)
    Julia Brody; Fiscal Year: 2004
    ..The study builds on the Cape Cod Breast Cancer and Environment Study of invasive breast cancer and additional grants that currently support the proposed study of DCIS. ..
  48. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  49. A Computational Docking Resource for Cancer Research
    Arthur Olson; Fiscal Year: 2006
    ..Formal training workshops will provide training on the most popular modeling and simulation methods to the wider NCI community. This Resource will both accelerate and extend research in Cancer Biology for the NCI community. ..
  50. ARNT:Roles in Tumor Induction and Growth, and Toxicity.
    Oliver Hankinson; Fiscal Year: 2006
    ..abstract_text> ..
  51. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  52. Early Determinants of Breast Cancer Risk
    Mary Beth Terry; Fiscal Year: 2006
    ..abstract_text> ..
  53. DNA Damage as Women Age: Implications for Breast Cancer
    DONALD MALINS; Fiscal Year: 2005
    ....
  54. MODIFIERS OF CARCINOGENESIS--ENVIRONMENTAL PAH MIXTURES
    William Baird; Fiscal Year: 2005
    ..This will aid in the development of methods for predicting the relative carcinogenic potency based upon the PAH composition of complex environmental mixtures. ..
  55. RASSF1 Tumor Suppressor Gene
    GERD PFEIFER; Fiscal Year: 2005
    ..The effect of RASSF1 expression on RAS signaling pathways will be studied. We will examine if RASSF1A, alone or in combination with activated RAS, induces cell death (apoptosis). ..
  56. EVALUATING EXPOSURES UNDER OSHAS 1984 ETO STANDARD
    Robert Herrick; Fiscal Year: 2001
    ..abstract_text> ..
  57. Breast Cancer Prevention and Treatment with Noni juice
    Mian Ying Wang; Fiscal Year: 2007
    ..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
  58. Synthesis of Novel Anticancer Agents
    MARISA KOZLOWSKI; Fiscal Year: 2007
    ..Routes to symmetric and dissymmetric chiral binaphthyl, perylenequinone, bisnaphthopyrone, bisanthraquinone, hypericin, and bisflavone natural products are presented. ..
  59. Designing Asymmetric Ligands Using Computational Techniques
    MARISA KOZLOWSKI; Fiscal Year: 2009
    ..The current proposal will create or retain four jobs. ..