emodin

Summary

Summary: Purgative anthraquinone found in several plants, especially Rhamnus frangula. It was formerly used as a laxative, but is now used mainly as tool in toxicity studies.

Top Publications

  1. ncbi Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
    Akihiro Muto
    Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawaku, Tokyo 142 8501, Japan
    Mol Cancer Ther 6:987-94. 2007
  2. ncbi Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation
    Ruey Shyang Chen
    Molecular Genetics of Microorganisms Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
    Exp Cell Res 315:2658-72. 2009
  3. ncbi Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway
    Qing Huang
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cancer Res 66:5807-15. 2006
  4. ncbi Sonodynamic effect of an anti-inflammatory agent--emodin on macrophages
    Qianping Gao
    Department of Pathophysiology, Harbin Medical University, Harbin, P R China
    Ultrasound Med Biol 37:1478-85. 2011
  5. ncbi Emodin-induced microglial apoptosis is associated with TRB3 induction
    Xueping Zhou
    the Clinical Research Institute, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Immunopharmacol Immunotoxicol 33:594-602. 2011
  6. ncbi Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1
    Xin Zhi Huang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:468-75. 2008
  7. ncbi Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
    Tai Lung Cha
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:2287-95. 2005
  8. ncbi Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats
    Jinping Wang
    Lab of Pharmacology and Toxicology, School of Pharmaceutical Science, Sun Yat Sen University, Guangzhou, 510080, China
    Eur J Pharmacol 553:297-303. 2006
  9. ncbi Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
    Bilel Jelassi
    Inserm U1069 Nutrition, Growth and Cancer, Universite Francois Rabelais de Tours, 10 boulevard Tonnelle, 37032 Tours, France
    Carcinogenesis 34:1487-96. 2013
  10. ncbi Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases
    Jung Min Yon
    College of Veterinary Medicine and Research Institute of Veterinary Medicine Priority Research Institute of NRF, Chungbuk National University, Cheongju 361 763, South Korea
    Reprod Toxicol 31:513-8. 2011

Detail Information

Publications285 found, 100 shown here

  1. ncbi Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor
    Akihiro Muto
    Department of Pathophysiology, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawaku, Tokyo 142 8501, Japan
    Mol Cancer Ther 6:987-94. 2007
    b>Emodin is an active component of a traditional Chinese and Japanese medicine isolated from the root and rhizomes of Rheum palmatum L...
  2. ncbi Emodin enhances gefitinib-induced cytotoxicity via Rad51 downregulation and ERK1/2 inactivation
    Ruey Shyang Chen
    Molecular Genetics of Microorganisms Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
    Exp Cell Res 315:2658-72. 2009
    b>Emodin, a tyrosine kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. It reportedly exhibits an anticancer effect on lung cancer...
  3. ncbi Emodin inhibits tumor cell adhesion through disruption of the membrane lipid Raft-associated integrin signaling pathway
    Qing Huang
    Department of Community, Occupational, and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
    Cancer Res 66:5807-15. 2006
    ..b>Emodin is the major active component of the rhizome of Rheum palmatum L., with known anticancer activities...
  4. ncbi Sonodynamic effect of an anti-inflammatory agent--emodin on macrophages
    Qianping Gao
    Department of Pathophysiology, Harbin Medical University, Harbin, P R China
    Ultrasound Med Biol 37:1478-85. 2011
    b>Emodin has been used as an anti-inflammatory agent and inflammation is a crucial feature of atherosclerosis. Here, we investigated the sonodynamic effect of emodin on macrophages, the pivotal inflammatory cells in atherosclerotic plaque...
  5. ncbi Emodin-induced microglial apoptosis is associated with TRB3 induction
    Xueping Zhou
    the Clinical Research Institute, First College of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, China
    Immunopharmacol Immunotoxicol 33:594-602. 2011
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a natural anthraquinone compound isolated from the rhizome of rhubarb, has been reported to treat brain injury after intracerebral hemorrhage...
  6. ncbi Emodin enhances cytotoxicity of chemotherapeutic drugs in prostate cancer cells: the mechanisms involve ROS-mediated suppression of multidrug resistance and hypoxia inducible factor-1
    Xin Zhi Huang
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Cancer Biol Ther 7:468-75. 2008
    ..In the present study, emodin, proven as a reactive oxygen species (ROS) generator by our previous work, was applied in combination with ..
  7. ncbi Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth
    Tai Lung Cha
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:2287-95. 2005
    ..Here, we show that emodin, a natural compound, can directly target AR to suppress prostate cancer cell growth in vitro and prolong the ..
  8. ncbi Inhibition of phosphorylation of p38 MAPK involved in the protection of nephropathy by emodin in diabetic rats
    Jinping Wang
    Lab of Pharmacology and Toxicology, School of Pharmaceutical Science, Sun Yat Sen University, Guangzhou, 510080, China
    Eur J Pharmacol 553:297-303. 2006
    To explore the protection of emodin on renal dysfunction in the streptozotocin-induced diabetic rats with nephropathy and the role of p38 mitogen-activated protein kinase (p38 MAPK) signal transduction pathway in this protection...
  9. ncbi Anthraquinone emodin inhibits human cancer cell invasiveness by antagonizing P2X7 receptors
    Bilel Jelassi
    Inserm U1069 Nutrition, Growth and Cancer, Universite Francois Rabelais de Tours, 10 boulevard Tonnelle, 37032 Tours, France
    Carcinogenesis 34:1487-96. 2013
    ..b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an anthraquinone derivative originally isolated from Rheum officinale ..
  10. ncbi Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases
    Jung Min Yon
    College of Veterinary Medicine and Research Institute of Veterinary Medicine Priority Research Institute of NRF, Chungbuk National University, Cheongju 361 763, South Korea
    Reprod Toxicol 31:513-8. 2011
    ..To determine whether emodin and [6]-gingerol affects hypoxia-induced anomalies during embryonic organogenesis, we cultured embryonic day 8...
  11. ncbi Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice
    Jianfeng Xue
    College of Life Sciences, Graduate University of Chinese Academy of Sciences, No 19 A Yu Quan Road, Beijing, China
    Fitoterapia 81:173-7. 2010
    Rheum palmatum Linn has been widely applied in the clinical treatment of diabetes mellitus. It has been found that emodin as the major bioactive component of R...
  12. ncbi Inhibitory effect of emodin on bleomycin-induced pulmonary fibrosis in mice
    Xiao hong Chen
    Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China
    Clin Exp Pharmacol Physiol 36:146-53. 2009
    1. Currently, there is no satisfactory treatment for pulmonary fibrosis. Emodin, a component in Chinese herbs, has been shown to have an antifibrotic effect on pancreatic fibrosis and liver fibrosis...
  13. ncbi Targeted abrogation of diverse signal transduction cascades by emodin for the treatment of inflammatory disorders and cancer
    Deepti Shrimali
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Cancer Lett 341:139-49. 2013
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a natural occurring anthraquinone derivative isolated from roots and barks of numerous plants, molds, and lichens...
  14. ncbi Emodin loaded solid lipid nanoparticles: preparation, characterization and antitumor activity studies
    Shengpeng Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Av Padre Tomás Pereira S J, Taipa, Macau, 999078, China
    Int J Pharm 430:238-46. 2012
    The objective of the present study was to prepare and characterize emodin (EMO)-loaded solid lipid nanoparticles (E-SLNs) and evaluate their antitumor activity in vitro...
  15. ncbi Emodin inhibits proinflammatory responses and inactivates histone deacetylase 1 in hypoxic rheumatoid synoviocytes
    Mi Kyoung Ha
    Graduate School of East West Medical Science, Kyung Hee University, Korea
    Biol Pharm Bull 34:1432-7. 2011
    ..In the present study, we investigated the anti-inflammatory effects of emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) isolated from the root of Rheum palmatum L...
  16. ncbi Enhanced antitumor efficacy by the combination of emodin and gemcitabine against human pancreatic cancer cells via downregulation of the expression of XIAP in vitro and in vivo
    Zhao Hong Wang
    Department of Hepatobiliary Pancreatic Surgery, the Second Affiliated Hospital of Wenzhou Medical College, No 109, West Xue yuan Road, Wenzhou 325027, P R China
    Int J Oncol 39:1123-31. 2011
    ..of this study was to explore the role of XIAP and NF-κB in potentiating the antitumor effect of gemcitabine by emodin in pancreatic cancer...
  17. ncbi Antiproliferative and antimetastatic effects of emodin on human pancreatic cancer
    An Liu
    Department of Surgery, the Second Affiliated Hospital of Wenzhou Medical College, No 109, West Xue yuan Road, Wenzhou 325027, PR China
    Oncol Rep 26:81-9. 2011
    b>Emodin (1, 3, 8-trihydroxy-6-methylanthraquinone) is an active constituent isolated from the root of Rheum palmatum L and is the main effective component of some Chinese herbs and plants...
  18. ncbi Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3
    Guan Hua Lai
    Division of Cellular and Molecular Pathogenesis, Department of Pathology, Medical College of Virginia Campus of Virginia Commonwealth University, Richmond, Virginia 23298 0297, USA
    Mol Cancer Ther 2:265-71. 2003
    b>Emodin, a tyrosine kinase inhibitor, effectively blocked tyrosine phosphorylation of p185(neu) overexpressed in cultured rat C611B cholangiocarcinoma (ChC) cells and in neu-transformed WB-F344 rat-liver epithelial stem-like cells (WBneu ..
  19. pmc Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation
    Miao Xian Dong
    The Institute of Medicine, Qiqihar Medical University, JianHua District, Qiqihar, Heilongjiang Province, China
    World J Gastroenterol 15:4753-62. 2009
    To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms.
  20. ncbi Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells
    Tak Mao Chan
    Department of Medicine, University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China
    Kidney Int 64:519-33. 2003
    b>Emodin ameliorates glucose-induced matrix synthesis in human peritoneal mesothelial cells...
  21. ncbi Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo
    Wang Chun-Guang
    Key Laboratory of Laboratory Medical Diagnostics, Ministry of Education, Chongqing Medical University, Chongqing 400016, PR China
    Eur J Pharmacol 627:33-41. 2010
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone derivative isolated from Rheum palmatum L, has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers...
  22. ncbi Emodin inhibits vascular endothelial growth factor-A-induced angiogenesis by blocking receptor-2 (KDR/Flk-1) phosphorylation
    Hee Jin Kwak
    Laboratory of Functional Genomics, Korea Institute of Radiological and Medical Sciences, Seoul, Korea
    Int J Cancer 118:2711-20. 2006
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone), an active component in the root and rhizome of Rheum palmatum, is a tyrosine kinase inhibitor with a number of biological activities, including antitumor effects...
  23. ncbi Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway
    Yu Ting Su
    Institute of Medical Science, China Medical University, Taichung, Taiwan, ROC
    Biochem Pharmacol 70:229-41. 2005
    b>Emodin, a natural anthraquinone derivative isolated from Rheum palmatum L., has been reported to exhibit anti-cancer effect on several human cancers such as liver cancers and lung cancers...
  24. ncbi Modulation of Rad51, ERCC1, and thymidine phosphorylase by emodin result in synergistic cytotoxic effect in combination with capecitabine
    Jen Chung Ko
    Department of Internal Medicine, Hsinchu Hospital, Department of Health, The Executive Yuan, Taiwan
    Biochem Pharmacol 81:680-90. 2011
    ..Overexpression of Rad51 and ERCC1 induce resistance to chemotherapeutic agents. Emodin, one of the main bioactive anthraquinone derivatives in the roots and rhizomes of numerous plants, possesses ..
  25. ncbi Antitumor and apoptosis-promoting properties of emodin, an anthraquinone derivative from Rheum officinale Baill, against pancreatic cancer in mice via inhibition of Akt activation
    Wei Tian Wei
    Department of Hepato Biliary Pancreatic Surgery, the Second Affiliated Hospital of Wenzhou Medical College, No 109, West Xue yuan Road, Wenzhou 325027, P R China
    Int J Oncol 39:1381-90. 2011
    ..b>Emodin is an active component of Chinese medicinal herbs and can inhibit the activation of Akt and NF-κB...
  26. ncbi Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway
    Jaung Gung Lin
    School of Chinese Medicine, China Medical University, Taiwan, Republic of China
    J Urol 175:343-7. 2006
    ..We investigated the anticancer effect of AE (1,8-dihydroy-3-[hydroxymethyl]-anthraquione) in the T24 human bladder cancer cell line (Food Industry Research and Development Institute, Hsinchu, Taiwan) by studying apoptosis regulation...
  27. ncbi Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation
    Yue Lu
    College of Pharmacy, Yeungnam University, Gyeongsan 712 749, Republic of Korea
    Biochem Pharmacol 82:1700-8. 2011
    ..b>Emodin, a naturally occurring anthraquinone derivative in oriental herbal medicines, has several beneficial pharmacologic ..
  28. pmc Emodin as an effective agent in targeting cancer stem-like side population cells of gallbladder carcinoma
    Xin Xing Li
    Division of General Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Stem Cells Dev 22:554-66. 2013
    ..We previously showed that 1,3,8-trihydroxy-6-methylanthraquinone (emodin), a reactive oxygen species (ROS) generator, enhanced sensitivity of gallbladder cancer SGC-996 cells to cisplatin ..
  29. ncbi Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma
    Xiao Chu
    Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, People s Republic of China
    Food Chem Toxicol 50:2368-75. 2012
    b>Emodin is a component from traditional Chinese herbal medicines...
  30. ncbi Emodin attenuates high glucose-induced TGF-β1 and fibronectin expression in mesangial cells through inhibition of NF-κB pathway
    Jie Yang
    Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    Exp Cell Res 319:3182-9. 2013
    ..Our previous studies demonstrated that emodin ameliorated renal injury and inhibited extracellular matrix accumulation in kidney and mesangial cells under ..
  31. ncbi Emodin suppresses cell proliferation and fibronectin expression via p38MAPK pathway in rat mesangial cells cultured under high glucose
    Xuejuan Li
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guagnzhou, Guangdong, China
    Mol Cell Endocrinol 307:157-62. 2009
    Our previous findings demonstrated that emodin could improve the renal function in rats with diabetic nephropathy, but little is known about its molecular mechanisms...
  32. ncbi Effect of emodin on endoplasmic reticulum stress in rats with severe acute pancreatitis
    Li Wu
    College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, People s Republic of China
    Inflammation 36:1020-9. 2013
    This study aimed to investigate the protective effect of emodin on endoplasmic reticulum (ER) stress in rats with severe acute pancreatitis (SAP) and the underlying molecular mechanism...
  33. ncbi Emodin suppresses interleukin-1beta induced mesangial cells proliferation and extracellular matrix production via inhibiting P38 MAPK
    Rong Wang
    Department of Nephrology, Shandong Provincial Hospital Shandong University, Jinan, Shandong, China
    Life Sci 80:2481-8. 2007
    Previous findings indicate that emodin has anti-proliferation and anti-fibrosis effects on several cell lines...
  34. pmc Antitumor activity of emodin against pancreatic cancer depends on its dual role: promotion of apoptosis and suppression of angiogenesis
    Sheng Zhang Lin
    Department of Hepato Biliary Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
    PLoS ONE 7:e42146. 2012
    b>Emodin has been showed to induce apoptosis of pancreatic cancer cells and inhibit tumor growth in our previous studies...
  35. ncbi Emodin potentiates the antitumor effects of gemcitabine in pancreatic cancer cells via inhibition of nuclear factor-κB
    An Liu
    Department of Surgery, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, P R China
    Mol Med Rep 4:221-7. 2011
    Many studies have demonstrated that emodin inhibits the growth and induces the apoptosis and chemo-sensitization of various cancer cells in animal models...
  36. ncbi Enhanced effect of gemcitabine by emodin against pancreatic cancer in vivo via cytochrome C-regulated apoptosis
    Hui Chen
    Department of Surgery, the Second Affiliated Hospital of Wenzhou Medical College, No 109, West Xue yuan Road, Wenzhou 325027, PR China
    Oncol Rep 25:1253-61. 2011
    ..b>Emodin, a natural anthraquinone derivative, is one such agent that has been shown to induce apoptosis in other tumor ..
  37. ncbi Exploration of Emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway
    Yan Ding
    Department of Gastroenterology and Hepatology, Medical and Health Center for Women and Children, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, PR China
    Eur J Pharmacol 590:377-86. 2008
    b>Emodin, 1,3,8-trihydroxy-6-methyl-anthraquinone, is an anthraquinone derivative from the roots of Rheum officinale Baill that has been used to treat many diseases in digestive system for thousands of years...
  38. ncbi Anti-glioma action of aloe emodin: the role of ERK inhibition
    S Mijatovic
    Institute for Biological Research, Despota Stefana 142, 11000, Belgrade, Serbia and Montenegro
    Cell Mol Life Sci 62:589-98. 2005
    The effect of aloe emodin (AE), a herbal anthraquinone derivative, on the rat C6 glioma cell line was investigated...
  39. ncbi Emodin sensitizes paclitaxel-resistant human ovarian cancer cells to paclitaxel-induced apoptosis in vitro
    Juan Li
    Department of Gynecology and Obstetrics, Qilu Hospital, Shandong University, Shandong 250012, P R China
    Oncol Rep 21:1605-10. 2009
    ..b>Emodin has been reported to sensitize human tumor cells to chemotherapeutic agents...
  40. ncbi Emodin induces embryonic toxicity in mouse blastocysts through apoptosis
    Mei Hui Chang
    Department of Bioscience Technology and Center for Nanotechnology, Chung Yuan Christian University, Chung Li, Taiwan
    Toxicology 299:25-32. 2012
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone), a major constituent of rhubarb, has a wide range of therapeutic applications...
  41. ncbi In vivo antioxidant action of a lignan-enriched extract of Schisandra fruit and an anthraquinone-containing extract of Polygonum root in comparison with schisandrin B and emodin
    P Y Chiu
    Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Planta Med 68:951-6. 2002
    ..of Polygonum multiflorum (PME) was compared with their respective active constituents schisandrin B (Sch B) and emodin by examining their effect on hepatic mitochondrial glutathione antioxidant status in control and carbon ..
  42. ncbi The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia
    M Mizuno
    Center for Transdisciplinary Research, Niigata University, Niigata, Japan
    J Neural Transm 115:521-30. 2008
    ..Here we investigated effects of the anthraquinone derivatives emodin (3-methyl-1,6,8-trihydroxyanthraquinone) and sennoside (bis-[D: -glucopyranosyl-oxy]-tetrahydro-4,4'-dihydroxy-..
  43. ncbi Neuroprotective effects of emodin in rat cortical neurons against beta-amyloid-induced neurotoxicity
    Tao Liu
    Department of Human Anatomy and Histology and Embryology, Medical School of Xi an Jiaotong University, Xi an, Shaanxi 710061, China
    Brain Res 1347:149-60. 2010
    ..In this study, the neuroprotective effect of emodin extracted from the traditional Chinese medicinal herb Polygonum cuspidatum Sieb...
  44. ncbi Emodin inhibits TNF-alpha-induced human aortic smooth-muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis
    Sook Kyoung Heo
    Cardiovascular Medical Research Center and Department of Prescriptionology University of Dongguk, Gyeongju City, Gyeongbuk 780 714, Republic of Korea
    J Cell Biochem 105:70-80. 2008
    ..It has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells; however, it is not known if ..
  45. ncbi The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
    Po Lin Kuo
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, ROC
    Life Sci 71:1879-92. 2002
    The aim of this study is to investigate the anticancer effect of aloe-emodin in two human liver cancer cell lines, Hep G2 and Hep 3B...
  46. ncbi Induction of defence mechanisms in grapevine leaves by emodin- and anthraquinone-rich plant extracts and their conferred resistance to downy mildew
    Sophie Godard
    Swiss Federal Research Station Agroscope Changins Wädenswil, Route de Duillier, P O Box 1012, CH 1260 Nyon, Switzerland
    Plant Physiol Biochem 47:827-37. 2009
    ..extracts contain many phenolic compounds belonging to the anthraquinone family, such as rhein, frangulin A, emodin, aloe-emodin, chrysophanol, and physcion. Emodin alone is able to impair P...
  47. ncbi Evaluation of the anti-angiogenic effect of aloe-emodin
    C Cardenas
    Procel Lab, Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, 29071, Malaga, Spain
    Cell Mol Life Sci 63:3083-9. 2006
    The present study identified aloe-emodin (AE, a hydroxyanthraquinone from Aloe vera and other plants) as a new anti-angiogenic compound with inhibitory effects in an in vivo angiogenesis assay and evaluates its effects on specific key ..
  48. pmc Effects of emodin on treating murine nonalcoholic fatty liver induced by high caloric laboratory chaw
    Hui Dong
    Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
    World J Gastroenterol 11:1339-44. 2005
    To investigate the effects of emodin on the treatment of non-alcoholic fatty liver in rats induced by high caloric laboratory chaw.
  49. ncbi Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma
    H Z Lee
    School of Pharmacy, China Medical College, 91, Hsueh Shih Road, Taichung, 404, Taiwan
    Eur J Pharmacol 431:287-95. 2001
    Aloe-emodin (1,8-dihydroxy-3-(hydroxymethyl)-anthraquinone) is an active component from the root and rhizome of Rheum palmatum...
  50. ncbi Emodin inhibits the growth of hepatoma cells: finding the common anti-cancer pathway using Huh7, Hep3B, and HepG2 cells
    Chin Mu Hsu
    School of Chinese Medicine, China Medical University, and Genetic Center, China Medical University Hospital, Taichung, Taiwan
    Biochem Biophys Res Commun 392:473-8. 2010
    b>Emodin--a major component of Rheum palmatum L.-exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways...
  51. ncbi Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production
    Yen Chou Chen
    Graduate Institute of Pharmacognosy Science, Taipei Medical University, 250 Wu Hsing Street, Taipei, Taiwan
    Biochem Pharmacol 64:1713-24. 2002
    b>Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is an active constituent of Rheum palmatum, and showed inhibitory activity on lipopolysaccharide-induced NO production in our previous study...
  52. ncbi Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent
    Gopal Srinivas
    Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram 695011, India
    Med Res Rev 27:591-608. 2007
    Anthraquinones represent a large family of compounds having diverse biological properties. Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, ..
  53. ncbi Emodin triggers DNA double-strand breaks by stabilizing topoisomerase II-DNA cleavage complexes and by inhibiting ATP hydrolysis of topoisomerase II
    Yan Li
    Center for Drug Safety Evaluation and Research, State Key Laboratory of New Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Toxicol Sci 118:435-43. 2010
    b>Emodin, an anthraquinone derived from a plant and fungi, has been reported to possess potential genotoxicity, but the mechanism is not entirely clear...
  54. ncbi Alteration of subcellular redox equilibrium and the consequent oxidative modification of nuclear factor kappaB are critical for anticancer cytotoxicity by emodin, a reactive oxygen species-producing agent
    Yawu Jing
    Department of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Free Radic Biol Med 40:2183-97. 2006
    We previously found that emodin produced reactive oxygen species (ROS) intracellularly...
  55. ncbi Suppression of ERCC1 and Rad51 expression through ERK1/2 inactivation is essential in emodin-mediated cytotoxicity in human non-small cell lung cancer cells
    Jen Chung Ko
    Department of Internal Medicine, Hsinchu Hospital, Department of Health, The Executive Yuan, Taiwan
    Biochem Pharmacol 79:655-64. 2010
    b>Emodin, a tyrosine kinase inhibitor, is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. Emodin exhibits anticancer effects against a variety of cancer cells, including lung cancer cells...
  56. pmc Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis
    Xian Ming Xia
    Department of Gastroenterology and Hepatology, Jinling Hospital, Nanjing 210002, Jiangsu Province, China
    World J Gastroenterol 16:2994-3001. 2010
    To investigate the effect of emodin on expression of claudin-4, claudin-5 and occludin, as well as the alveolar epithelial barrier in rats with pancreatitis induced by sodium taurocholate.
  57. ncbi Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): structure-requirement of hydroxyanthraquinones for estrogenic activity
    H Matsuda
    Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, 607-8412, Kyoto, Japan
    Bioorg Med Chem Lett 11:1839-42. 2001
    ..By bioassay-guided separation from P. cuspidatum with the most potent activity, emodin and emodin 8-O-beta-D-glucopyranoside were isolated as active principles...
  58. ncbi Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways
    Shuw Yuan Lin
    Department of Food and Nutrition, Hung Kuang University, Taichung, Taiwan
    Anticancer Res 29:327-35. 2009
    b>Emodin was isolated from Rheum palmatum L. and exhibits an anticancer effect on human cancer cell lines, however, the molecular mechanisms of emodin-mediated apoptosis in human tongue cancer cells have not been fully investigated...
  59. ncbi Emodin enhances sensitivity of gallbladder cancer cells to platinum drugs via glutathion depletion and MRP1 downregulation
    Wei Wang
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, China
    Biochem Pharmacol 79:1134-40. 2010
    ..In the present study, we tested the effect of emodin (1,3,8-trihydroxy-6-methylanthraquinone), a reactive oxygen species (ROS) generator reported by our group ..
  60. pmc Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome
    Stefan Uhle
    Division of Molecular Biology, Department of Surgery, Institute of Toxicology, Medical Faculty Charité, Humboldt University, Monbijoustrasse 2, D 10117 Berlin, Germany
    EMBO J 22:1302-12. 2003
    ..CK2 phosphoryl ates Thr155, which targets p53 to degradation by the Ub system. Curcumin, emodin, DRB and resveratrol block CSN-associated kinases and induce degradation of c-Jun in HeLa cells...
  61. pmc Silk-fibroin-coated liposomes for long-term and targeted drug delivery
    Andrea S Gobin
    University of Texas MD Anderson Cancer Center, Laboratory of Reparative Biology and Bioengineering, Plastic Surgery, Houston, TX 72230, USA
    Int J Nanomedicine 1:81-7. 2006
    ..report, the structural properties, drug release kinetics, and therapeutic availability of silk-fibroin-coated, emodin-loaded liposomes (SF-ELP), compared with uncoated, emodin-loaded liposomes (ELP), were investigated...
  62. ncbi Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway
    Q Huang
    Department of Community, Occupational, and Family Medicine, Faculty of Medicine, National University of Singapore
    Cell Mol Life Sci 62:1167-75. 2005
    ..We found that emodin (3-methyl-1,6,8-trihydroxyanthraquinone), an active component from the rhizome of Rheum palmatum, significantly ..
  63. ncbi Emodin has cytotoxic and protective effects in rat C6 glioma cells: roles of Mdr1a and nuclear factor kappaB in cell survival
    Tzu Ching Kuo
    Department of Microbiology, China Medical University, 91, Hsueh Shih Road, Taichung 404, Taiwan
    J Pharmacol Exp Ther 330:736-44. 2009
    1,3,8-Trihydroxy-6-methylanthaquinone (emodin) is recognized as an antiproliferative compound...
  64. pmc Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells
    Guoquan Meng
    Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan, China
    Br J Pharmacol 161:1628-44. 2010
    b>Emodin [1,3,8-trihydroxy-6-methylanthraquinone] has been reported to exhibit vascular anti-inflammatory properties. However, the corresponding mechanisms are not well understood...
  65. ncbi Silk fibroin mediated delivery of liposomal emodin to breast cancer cells
    Sangeeta K Cheema
    University of Texas M D Anderson Cancer Center, Departments of Biomedical Engineering and Plastic Surgery, Unit 602, P O Box 301402, Houston, TX 72230 1402, United States
    Int J Pharm 341:221-9. 2007
    ..and efficacy of silk fibroin coated liposomes (SF-ELP), encapsulating a receptor tyrosine kinase inhibitor, emodin, on Her2/neu over-expressing breast cancer cells, was investigated...
  66. ncbi Emodin, aloe-emodin and rhein inhibit migration and invasion in human tongue cancer SCC-4 cells through the inhibition of gene expression of matrix metalloproteinase-9
    Ya Yin Chen
    School of Chinese Medicine, China Medical University, Taichung 404, Taiwan, R O C
    Int J Oncol 36:1113-20. 2010
    b>Emodin, aloe-emodin and rhein are major compounds in rhubarb (Rheum palmatum L.), used in Chinese herbal medicine, and found to have antitumor properties including cell cycle arrest and apoptosis in many human cancer cells...
  67. pmc Emodin, a natural product, selectively inhibits 11beta-hydroxysteroid dehydrogenase type 1 and ameliorates metabolic disorder in diet-induced obese mice
    Ying Feng
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
    Br J Pharmacol 161:113-26. 2010
    ..b>Emodin, a natural product and active ingredient of various Chinese herbs, has been demonstrated to possess multiple ..
  68. ncbi Emodin induces a reactive oxygen species-dependent and ATM-p53-Bax mediated cytotoxicity in lung cancer cells
    Jin Mei Lai
    Department of Life Science, Fu Jen Catholic University, Taipei County, Taiwan
    Eur J Pharmacol 623:1-9. 2009
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone), a natural anthraquinone compound isolated from the rhizome of rhubarb, has been reported to suppress tumor growth in many clinical situations...
  69. ncbi Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells
    Cuifen Wang
    Jiangsu Center for Drug Screening, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China Department of Pharmacology, Southeast University, Nanjing 210009, China
    Toxicol Lett 181:196-204. 2008
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) and rhein (4,5-dihydroxyanthraquinone-2-carboxyl acid) are two main active compounds in total rhubarb anthraquinones (TRAs), which showed nephrotoxicity in Sprague Dawley (S.D...
  70. ncbi Emodin enhances arsenic trioxide-induced apoptosis via generation of reactive oxygen species and inhibition of survival signaling
    Jing Yi
    Department of Cell Biology, Shanghai Second Medical University, Shanghai, People s Republic of China
    Cancer Res 64:108-16. 2004
    ..b>Emodin, a natural anthraquinone derivative, was selected because its semiquinone structure is likely to increase the ..
  71. ncbi Effects of emodin on synaptic transmission in rat hippocampal CA1 pyramidal neurons in vitro
    Jian Wen Gu
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Neuropharmacology 49:103-11. 2005
    ..To this end, the effects of emodin, an anthraquinone derivative extracted from Rheum tanguticum Maxim. Ex...
  72. pmc Emodin-induced generation of reactive oxygen species inhibits RhoA activation to sensitize gastric carcinoma cells to anoikis
    Jun Cai
    Departments of Cell Biology, Key Laboratory of The Education Ministry for Cell Differentiation and Apoptosis, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Neoplasia 10:41-51. 2008
    ..Oxidative stress caused by emodin, an ROS producer, in combination with arsenic trioxide (ATO) led to RhoA inactivation that triggered structural ..
  73. ncbi Emodin-induced apoptosis through p53-dependent pathway in human hepatoma cells
    Den En Shieh
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Life Sci 74:2279-90. 2004
    ..In this study, the cytotoxic effect of emodin on various human hepatoma cell lines was investigated...
  74. ncbi Immunosuppressive effects of emodin: an in vivo and in vitro study
    Y X Liu
    Department of Hepatobiliary Surgery, The First Affiliated Hospital, Medical College, Xi an Jiaotong University, Xi an, China
    Transplant Proc 41:1837-9. 2009
    We sought to investigate the immunosuppressive effects of emodin and its potential in vivo and in vitro mechanisms.
  75. ncbi Evaluation of the antibacterial activity of Ventilago madraspatana Gaertn., Rubia cordifolia Linn. and Lantana camara Linn.: isolation of emodin and physcion as active antibacterial agents
    Subhalakshmi Basu
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    Phytother Res 19:888-94. 2005
    ..In the course of bio-assay guided fractionation, emodin and physcion were isolated for the first time from the stem-bark of V. madraspatana...
  76. ncbi Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: a study on its mechanism of action
    Birgitte B Olsen
    University of Southern Denmark, Institute of Biochemistry and Molecular Biology, Campusvej 55, 5230 Odense M, Denmark
    Int J Biochem Cell Biol 39:227-37. 2007
    ..b>Emodin is a natural anthraquinone derivative that exhibits anti-proliferative effects in various cancer cell lines by ..
  77. ncbi Emodin and baicalein inhibit pancreatic stromal derived factor-1 expression in rats with acute pancreatitis
    Zong Fang Li
    Department of Surgery, Second Affiliated Hospital, School of Medicine, Xi an Jiaotong University, Xi an 710004, China
    Hepatobiliary Pancreat Dis Int 8:201-8. 2009
    ..b>Emodin, an anthraquinone derivative from Radix et Rhizoma Rhei, and baicalein, a flavone from Scutellaria baicalensis ..
  78. ncbi Signal pathways involved in emodin-induced contraction of smooth muscle cells from rat colon
    Tao Ma
    Department of Surgery, General Hospital of Tianjin Medical University, Tianjin 300052, China
    World J Gastroenterol 10:1476-9. 2004
    To investigate the effects induced by emodin on single smooth muscle cells from rat colon in vitro, and to determine the signal pathways involved.
  79. ncbi Role of Rad51 down-regulation and extracellular signal-regulated kinases 1 and 2 inactivation in emodin and mitomycin C-induced synergistic cytotoxicity in human non-small-cell lung cancer cells
    Ying Jhen Su
    Molecular Oncology Laboratory, Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan
    Mol Pharmacol 77:633-43. 2010
    b>Emodin (1,3,8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone derivative found in the roots and rhizomes of numerous plants. It is a tyrosine kinase inhibitor and has anticancer effects on lung cancer...
  80. ncbi Aloe emodin suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture
    Sun Wook Woo
    Department of Pharmacy, Medicinal Resources Research Center, Wonkwang University, Iksan, Jeonbuk 570 749, South Korea
    Pharmacol Toxicol 90:193-8. 2002
    We have studied the inhibitory effect of aloe emodin on hepatic stellate cells activation and proliferation, as these cells play a key role in the pathogenesis of hepatic fibrosis...
  81. ncbi Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons
    Yun Gao
    Department of Physiology, Medical College of Nanchang University, Bayi Road 461, Nanchang, Jiangxi, PR China
    Brain Res Bull 84:406-13. 2011
    ..The P2X(2/3) receptors play a crucial role in facilitating the transmission of pain at neuropathic pain states. Emodin is a natural anthraquinone in rhubarb...
  82. ncbi The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo
    Hai rong Xiong
    State Key Laboratory of Virology, Institute of Medical Virology, Research Center of Food and Drug Evaluation, School of Medicine, Wuhan University, 185 DongHu Road, Wuhan 430071, PR China
    J Ethnopharmacol 133:718-23. 2011
    ..Rhubarb is one of the oldest and best-known traditional Chinese medicines. We initiated this study to test if emodin is the active ingredients from Rheum tanguticum (R...
  83. ncbi Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity
    Young Min Han
    Laboratory of Chemical Genomics and Biology, Korea Research Institute of Bioscience and Biotechnology, 1125 Gwahakro, Yoosunggu, Daejeon 305 600, Republic of Korea
    Bioorg Med Chem Lett 22:323-6. 2012
    ..b>Emodin strongly inhibited phosphatase activity of PRL-3 with IC(50) values of 3...
  84. ncbi Emodin inhibits the differentiation and maturation of dendritic cells and increases the production of regulatory T cells
    Wei Zhang
    Department of Surgery, the Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, PR China
    Int J Mol Med 29:159-64. 2012
    The aim of this study was to characterize the effects of emodin on dendritic cells (DCs) and CD4⁺CD25⁺ regulatory T cells (Tregs)...
  85. ncbi Promotion of adiponectin multimerization by emodin: a novel AMPK activator with PPARγ-agonist activity
    Zhifen Chen
    MOE Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China
    J Cell Biochem 113:3547-58. 2012
    ..In this study, we reported that emodin, a natural product and active ingredient of various Chinese herbs, activates AMPK in both 3T3-L1 adipocytes and ..
  86. pmc Emodin regulates glucose utilization by activating AMP-activated protein kinase
    Parkyong Song
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, Kyungbuk 790 784, Republic of Korea
    J Biol Chem 288:5732-42. 2013
    ..As a result, emodin, a natural anthraquinone derivative, was shown to stimulate AMPK activity in skeletal muscle and liver cells...
  87. ncbi Emodin and rhein inhibit LIGHT-induced monocytes migration by blocking of ROS production
    Sook Kyoung Heo
    Cardiovascular Medical Research Center and Department of Prescriptionology, University of Dongguk, Gyeongju City, Gyeongbuk 780 714, Republic of Korea
    Vascul Pharmacol 53:28-37. 2010
    LIGHT is known to act as a novel mediator for atherogenesis. Furthermore, it has been reported that emodin, an active component extracted from rhubarb, can stop the growth of cancer cells...
  88. ncbi Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis
    Gang Wang
    Department of Hepatobiliary Pancreatic Surgery, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng St, Nangang Dist 150001, Harbin, Heilongjiang, People s Republic of China
    Inflamm Res 59:479-88. 2010
    In the present experiment, we aimed to determine the feasibility and curative effects of emodin combined with danshensu on experimental severe acute pancreatitis (SAP) and the mutual benefit of this synergistic strategy by a prospective ..
  89. ncbi Emodin ameliorates lipopolysaccharide-induced mastitis in mice by inhibiting activation of NF-κB and MAPKs signal pathways
    Depeng Li
    Department of Clinical Veterinary Medicine, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, Jilin province 130062, People s Republic of China
    Eur J Pharmacol 705:79-85. 2013
    b>Emodin is an anthraquinone derivative from the Chinese herb Radix et Rhizoma Rhei...
  90. ncbi Emodin suppresses inflammatory responses and joint destruction in collagen-induced arthritic mice
    Jin Ki Hwang
    Department of Oral Biochemistry, Wonkwang University, Iksan City, Jeonbuk, South Korea
    Rheumatology (Oxford) 52:1583-91. 2013
    b>Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) is one of the active components present in the root and rhizome of Rheum palmatum...
  91. pmc Emodin inhibits growth and induces apoptosis in an orthotopic hepatocellular carcinoma model by blocking activation of STAT3
    Aruljothi Subramaniam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Molecular Toxicology Lab, Department of Biotechnology, Bharathiar University, Coimbatore, India
    Br J Pharmacol 170:807-21. 2013
    ..Here, we have investigated whether emodin mediates its effect through interference with the STAT3 activation pathway in HCC.
  92. ncbi Emodin suppresses hyaluronic acid-induced MMP-9 secretion and invasion of glioma cells
    Mi Suk Kim
    Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, Korea
    Int J Oncol 27:839-46. 2005
    b>Emodin, an inhibitor of protein tyrosine kinase, possesses antiviral, immunosuppressive, anti-inflammatory and anticancer effects...
  93. ncbi Destabilization of CARP mRNAs by aloe-emodin contributes to caspase-8-mediated p53-independent apoptosis of human carcinoma cells
    Meng Liang Lin
    Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan
    J Cell Biochem 112:1176-91. 2011
    ..FaDu (human pharyngeal squamous cell carcinoma), Hep3B (hepatoma), and MG-63 (osteosarcoma) cells induced by aloe-emodin (AE) are p53-independent...
  94. ncbi Emodin inhibits invasion and migration of prostate and lung cancer cells by downregulating the expression of chemokine receptor CXCR4
    Sooho Ok
    College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Immunopharmacol Immunotoxicol 34:768-78. 2012
    b>Emodin (ED), an anthraquinone derivative, has been found to inhibit proliferation, induce apoptosis, suppress angiogenesis, impede metastasis, and enhance chemotherapy...
  95. ncbi Toxicity induced by emodin on zebrafish embryos
    Qiuxia He
    Biology Institute of Shandong Academy of Sciences, Jinan, Shandong, China
    Drug Chem Toxicol 35:149-54. 2012
    b>Emodin, a widely available herbal remedy, has a variety of pharmacological actions and valuable clinical applications. The potential effect of emodin on zebrafish (Danio rerio) embryos was evaluated...
  96. ncbi Capillary electrophoresis for simultaneous determination of emodin, chrysophanol, and their 8-beta-D-glucosides
    Junko Koyama
    Kobe Pharmaceutical University, Higashinada ku, Japan
    Chem Pharm Bull (Tokyo) 51:418-20. 2003
    The simultaneous separation and determination of the major anthraquinones, emodin, chrysophanol, and their glucosides, of Rumex japonicus HOUTT., and emodin and emodin glucoside, of Cassia tora L., Rhamnus purshiana DC...
  97. ncbi Synthesis, DNA binding and cytotoxicity of new pyrazole emodin derivatives
    J H Tan
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510080, China
    Eur J Med Chem 41:1041-7. 2006
    A series of new anthrapyrazoles were derived from emodin by attaching various cationic alkyl amino side chains onto a pyrazole ring which had been incorporated into the anthraquinone chromophore...
  98. ncbi Emodin with PPARgamma ligand-binding activity promotes adipocyte differentiation and increases glucose uptake in 3T3-Ll cells
    Ying Yang
    Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, 197 Ruijin Road II, Shanghai 200025, China
    Biochem Biophys Res Commun 353:225-30. 2007
    b>Emodin, one of the main active components in the root and rhizome of Rheum palmatum L, promoted the conversion of 3T3-L1 fibroblasts to adipocytes, as evidenced by increased glycerol-3-phosphate dehydrogenase (GPDH) activity and the ..
  99. ncbi [Experimental study on anti-metastasis effect of emodin on human pancreatic cancer]
    An Liu
    First People Hospital of Yueyang, Yueyang 414000, China
    Zhongguo Zhong Yao Za Zhi 36:3167-71. 2011
    To investigate the anti-metastasis effect of emodin on the pancreatic cancer in vitro and in vivo.
  100. pmc Inhibition kinetics and emodin cocrystal structure of a type II polyketide ketoreductase
    Tyler Paz Korman
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697, USA
    Biochemistry 47:1837-47. 2008
    ..cocrystal structures of actinorhodin polyketide ketoreductase (actKR) bound with NADPH or NADP+ and the inhibitor emodin were solved with the wild type and P94L mutant of actKR, revealing the first observation of a bent p-quinone in an ..
  101. ncbi Apoptosis-inducing activity of new pyrazole emodin derivatives in human hepatocellular carcinoma HepG2 cells
    Xiao Dong Wang
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou, China
    Biol Pharm Bull 30:1113-6. 2007
    A series of new pyrazole derivatives from emodin synthesized in our lab have been shown to have much stronger cytotoxicity than emodin against various tumor cell lines...

Research Grants5

  1. Chemopreventive properties of aryl hydrocarbon receptor antagonists
    Hollie Swanson; Fiscal Year: 2007
    ..cigarette smoke condensate can act as AHR agonists and that several dietary flavonoids, in particular, apigenin, emodin and kaempferol appear to act as effective AHR antagonists...
  2. Biomimetic Scaffolds for Abdominal Wall Repair
    Anshu Mathur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  3. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud Elsohly; Fiscal Year: 2003
    ..abstract_text> ..
  4. Compositions for Prevention/Prophylactic Treatment of Poison Ivy Dermatitis
    Mahmoud Elsohly; Fiscal Year: 2006
    ..This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem. [unreadable] [unreadable]..