plant extracts

Summary

Summary: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.

Top Publications

  1. ncbi Antioxidant activity of plant extracts containing phenolic compounds
    M P Kähkönen
    Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Agric Food Chem 47:3954-62. 1999
  2. ncbi Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
    Yizhong Cai
    Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    Life Sci 74:2157-84. 2004
  3. ncbi Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'
    Paul Cos
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    J Ethnopharmacol 106:290-302. 2006
  4. ncbi Antioxidant activity and phenolic compounds in selected herbs
    W Zheng
    Fruit Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 49:5165-70. 2001
  5. ncbi Potential of Cameroonian plants and derived products against microbial infections: a review
    Victor Kuete
    Department of Biochemistry, University of Dschang, Dschang, Cameroon
    Planta Med 76:1479-91. 2010
  6. ncbi Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants
    A Mishra
    University of Allahabad, Department of Biochemistry, Allahabad, India
    Cell Mol Biol (Noisy-le-grand) 57:16-25. 2011
  7. ncbi Medicinal plants: traditions of yesterday and drugs of tomorrow
    Ameenah Gurib-Fakim
    Faculty of Science, University of Mauritius, Reduit, Mauritius
    Mol Aspects Med 27:1-93. 2006
  8. ncbi A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
    J N Eloff
    Department of Pharmacology, University of Pretoria, South Africa
    Planta Med 64:711-3. 1998
  9. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
  10. ncbi Synergy research: approaching a new generation of phytopharmaceuticals
    H Wagner
    Department of Pharmacy, Center of Pharma Research, Ludwig Maximilians University, Butenandtstr 5 13, House B, D 81377 Munich, Germany
    Phytomedicine 16:97-110. 2009

Detail Information

Publications320 found, 100 shown here

  1. ncbi Antioxidant activity of plant extracts containing phenolic compounds
    M P Kähkönen
    Department of Applied Chemistry, Division of Food Chemistry, University of Helsinki, FIN 00014, Helsinki, Finland
    J Agric Food Chem 47:3954-62. 1999
    ..In addition, potato peel and beetroot peel extracts showed strong antioxidant effects. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed...
  2. ncbi Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer
    Yizhong Cai
    Department of Botany, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China
    Life Sci 74:2157-84. 2004
    ..Traditional Chinese medicinal plants associated with anticancer might be potential sources of potent natural antioxidants and beneficial chemopreventive agents...
  3. ncbi Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept'
    Paul Cos
    Laboratory for Microbiology, Parasitology and Hygiene LMPH, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, 2610 Antwerp, Belgium
    J Ethnopharmacol 106:290-302. 2006
    Natural products, either as pure compounds or as standardized plant extracts, provide unlimited opportunities for new drug leads because of the unmatched availability of chemical diversity...
  4. ncbi Antioxidant activity and phenolic compounds in selected herbs
    W Zheng
    Fruit Laboratory, Beltsville Agricultural Research Center, Agricultural Research Service, U. S. Department of Agriculture, Beltsville, Maryland 20705, USA
    J Agric Food Chem 49:5165-70. 2001
    ..longiflora, whereas quercetin-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside and kaempferol-3-O-rhamnosyl-(1 --> 2)-rhamnosyl-(1 --> 6)-glucoside were predominant phenolic compounds in Ginkgo biloba leaves...
  5. ncbi Potential of Cameroonian plants and derived products against microbial infections: a review
    Victor Kuete
    Department of Biochemistry, University of Dschang, Dschang, Cameroon
    Planta Med 76:1479-91. 2010
    ..However, much work is still to be done to standardize methods and cut-off points for describing the antimicrobial activity, and on the study of the mechanisms of action...
  6. ncbi Studies on in vitro antioxidant and antistaphylococcal activities of some important medicinal plants
    A Mishra
    University of Allahabad, Department of Biochemistry, Allahabad, India
    Cell Mol Biol (Noisy-le-grand) 57:16-25. 2011
    ..Total phenolic contents in plant extracts were estimated and different amounts of phenolic contents were found in B. variegata, T. cardifolia and P...
  7. ncbi Medicinal plants: traditions of yesterday and drugs of tomorrow
    Ameenah Gurib-Fakim
    Faculty of Science, University of Mauritius, Reduit, Mauritius
    Mol Aspects Med 27:1-93. 2006
    ..The paper also presents some data on the use of plant products in the development of functional foods, addresses the needs for validation of plant extracts and always stressing on safety, efficacy and quality of phyto-medications.
  8. ncbi A sensitive and quick microplate method to determine the minimal inhibitory concentration of plant extracts for bacteria
    J N Eloff
    Department of Pharmacology, University of Pretoria, South Africa
    Planta Med 64:711-3. 1998
    Agar diffusion techniques are used widely to assay plant extracts for antimicrobial activity, but there are problems associated with this technique...
  9. ncbi Medicinal properties of mangosteen (Garcinia mangostana)
    José Pedraza-Chaverri
    Facultad de Quimica, Departamento de Biologia, Universidad Nacional Autonoma de Mexico, Ciudad Universitaria, 04510 Mexico, DF, Mexico
    Food Chem Toxicol 46:3227-39. 2008
    ..The aim of this review is to summarize findings of beneficial properties of GML's extracts and xanthones isolated from this plant so far...
  10. ncbi Synergy research: approaching a new generation of phytopharmaceuticals
    H Wagner
    Department of Pharmacy, Center of Pharma Research, Ludwig Maximilians University, Butenandtstr 5 13, House B, D 81377 Munich, Germany
    Phytomedicine 16:97-110. 2009
    ..This new generation of phytopharmaceuticals could lend phytotherapy a new legitimacy and enable their use to treat diseases which have hitherto been treated using synthetic drugs alone...
  11. ncbi Oxidative DNA damage protective activity, antioxidant and anti-quorum sensing potentials of Moringa oleifera
    Brahma N Singh
    Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Mushlim University, Aligarh 202 001, India
    Food Chem Toxicol 47:1109-16. 2009
    ..Eventually, LE and FE were found to inhibit violacein production, a QS-regulated behavior in Chromobacterium violaceum 12472...
  12. pmc Synthesis of silver nanoparticles using Dioscorea bulbifera tuber extract and evaluation of its synergistic potential in combination with antimicrobial agents
    Sougata Ghosh
    Institute of Bioinformatics and Biotechnology, University of Pune, Pune, India
    Int J Nanomedicine 7:483-96. 2012
    ..In this paper, we report on the rapid synthesis of silver nanoparticles by reduction of aqueous Ag(+) ions using D. bulbifera tuber extract...
  13. ncbi In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    Navindra P Seeram
    Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Nutr Biochem 16:360-7. 2005
    ..The superior bioactivity of PJ compared to its purified polyphenols illustrated the multifactorial effects and chemical synergy of the action of multiple compounds compared to single purified active ingredients...
  14. ncbi Potential synergy of phytochemicals in cancer prevention: mechanism of action
    Rui Hai Liu
    Department of Food Science, Cornell University, Ithaca, NY 14853, USA
    J Nutr 134:3479S-3485S. 2004
    ....
  15. ncbi Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method
    L L Mensor
    Departamento de Produtos Naturais e Alimentos, , Universidade Federal do Rio de Janeiro, , Bl. A, , Rio de Janeiro, 21941-590 RJ, Brazil
    Phytother Res 15:127-30. 2001
    Brazilian plant extracts belonging to 16 species of 5 different families (71 extracts) were tested against the stable DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) free-radical...
  16. ncbi Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
    ..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...
  17. pmc Synthesis of silver nanoparticles by using tea leaf extract from Camellia sinensis
    Yuet Ying Loo
    Centre of Excellent for Food Safety Research, Faculty of Food Science and Technology, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:4263-7. 2012
    The development of the biological synthesis of nanoparticles using microorganisms or plant extracts plays an important role in the field of nanotechnology as it is environmentally friendly and does not involve any harmful chemicals...
  18. ncbi Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts
    Sebastian Jäger
    Carl Gustav Carus Institute, Am Eichhof 30, D 75223 Niefern Oschelbronn, Germany
    Molecules 14:2016-31. 2009
    ..They are quantitatively characterised plant extracts supplying a high concentration of actives and therefore can be used for development of phytopharmaceutical ..
  19. pmc Green biosynthesis of silver nanoparticles using Curcuma longa tuber powder
    Kamyar Shameli
    Department of Chemistry, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Int J Nanomedicine 7:5603-10. 2012
    ..The most needed outcome of this work will be the development of value-added products from C. longa for biomedical and nanotechnology-based industries...
  20. ncbi Tannin-rich fraction from Terminalia catappa inhibits quorum sensing (QS) in Chromobacterium violaceum and the QS-controlled biofilm maturation and LasA staphylolytic activity in Pseudomonas aeruginosa
    Joemar C Taganna
    Laboratory of Applied Microbiology, Institute of Biology, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines
    J Ethnopharmacol 134:865-71. 2011
    ..The study aimed to test the activity of Terminalia catappa L. against bacterial quorum sensing (QS) in order to provide a potential scientific basis for the traditional use of leaf extracts of this plant as an antiseptic...
  21. ncbi Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer
    Ephraim P Lansky
    Punisyn Pharmaceuticals Ltd, Haifa, Israel
    J Ethnopharmacol 109:177-206. 2007
    ....
  22. ncbi Hepatoprotective and free radical scavenging activities of phenolic petrosins and flavonoids isolated from Equisetum arvense
    Hyuncheol Oh
    Laboratory of Cell Signaling Regulation, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305 333, South Korea
    J Ethnopharmacol 95:421-4. 2004
    ..8 +/- 0.4 microM and 22.7 +/- 2.8 microM, respectively). These results support the use of this plant for the treatment of hepatitis in oriental traditional medicine...
  23. ncbi Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo
    David Goh
    Applied Science School, Temasek Polytechnic, 21 Tampinese Avenue 1, Singapore 529757, Republic of Singapore
    J Agric Food Chem 53:8197-204. 2005
    ..This included a network of proteins involved in metabolism, regulation of the cell cycle, and transcription-factor activity...
  24. pmc Heme oxygenase 1, beneficial role in permanent ischemic stroke and in Gingko biloba (EGb 761) neuroprotection
    Z A Shah
    Department of Medicinal and Biological Chemistry, College of Pharmacy and Pharmaceutical Sciences, University of Toledo, Toledo, OH 43614, USA
    Neuroscience 180:248-55. 2011
    ..Together, these results suggest that HO1 plays, at least in part, an important role in the neuroprotective mechanism of EGb 761 and in delayed ischemia. Targeting this pathway could lead to neuroprotective agents against ischemic stroke...
  25. ncbi Aged garlic extract enhances production of nitric oxide
    Naoaki Morihara
    Healthcare Research Institute, Wakunaga Pharmaceutical Co Ltd, 1624 Shimokotachi, Kodacho Takatagun, 739 1195, Hiroshima, Japan
    Life Sci 71:509-17. 2002
    ..These results indicate that AGE increased NO production by activating cNOS, but not iNOS. The arginine contained in AGE was not responsible for the effect. AGE may be a useful tool for the prevention of cardiovascular disease...
  26. ncbi Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms
    Kazuhiro Ishiguro
    Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    Biochem Biophys Res Commun 362:218-23. 2007
    ....
  27. ncbi Studies on the antioxidant activity of pomegranate (Punica granatum) peel and seed extracts using in vitro models
    R P Singh
    Human Resource Development, Central Food Technological Research Institute, Mysore 570 013, India
    J Agric Food Chem 50:81-6. 2002
    ..Owing to this property, the studies can be further extended to exploit them for their possible application for the preservation of food products as well as their use as health supplements and neutraceuticals...
  28. ncbi Cytotoxicity of plants from Malaysia and Thailand used traditionally to treat cancer
    C C Lee
    Department of Pharmacy, King s College London, London SE1 9NN, UK
    J Ethnopharmacol 100:237-43. 2005
    ..59 microM). The Malaysian Alpinia galanga showed weak activity compared with the Thai sample and this was shown to be due to the relatively high amounts of 1'-acetoxychavicol acetate present in the Thai sample...
  29. ncbi Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells
    Jae Hee Hyun
    School of Medicine, Institute of Medical Sciences, Jeju National University, South Kore
    Biol Pharm Bull 32:1760-4. 2009
    ..These data support the hypothesis that fucoidan may have potential in colon cancer treatment...
  30. pmc Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L
    Naima Saeed
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad, 45320, Pakistan
    BMC Complement Altern Med 12:221. 2012
    ....
  31. ncbi Plant phenolics: extraction, analysis and their antioxidant and anticancer properties
    Jin Dai
    Four Tigers LLC, 1501 Bull Lea Road, Suite 105, Lexington, Kentucky 40511, USA
    Molecules 15:7313-52. 2010
    ..Finally, possible mechanisms of action involving antioxidant and pro-oxidant activity as well as interference with cellular functions are discussed...
  32. ncbi Inhibition of bacterial quorum sensing by vanilla extract
    J H Choo
    Department of Biotechnology, Yonsei University, Seoul, Republic of Korea
    Lett Appl Microbiol 42:637-41. 2006
    ..The purpose of this study was to search for a novel quorum sensing inhibitor and analyse its inhibitory activity...
  33. ncbi Analysis of antioxidant activities of common vegetables employing oxygen radical absorbance capacity (ORAC) and ferric reducing antioxidant power (FRAP) assays: a comparative study
    Boxin Ou
    Brunswick Laboratories, 6 Thacher Lane, Wareham, Massachusetts 02571, USA
    J Agric Food Chem 50:3122-8. 2002
    ..On the basis of the ORAC results, green pepper, spinach, purple onion, broccoli, beet, and cauliflower are the leading sources of antioxidant activities against the peroxyl radicals...
  34. pmc Memecylon edule leaf extract mediated green synthesis of silver and gold nanoparticles
    Tamizhamudu Elavazhagan
    Centre for Interdisciplinary Research, Directorate of Research, SRM University, Kattankulathur, Tamilnadu, India
    Int J Nanomedicine 6:1265-78. 2011
    ..The characterized nanoparticles of M. edule have potential for various medical and industrial applications. Saponin presence in aqueous extract of M. edule is responsible for the mass production of silver and gold nanoparticles...
  35. ncbi Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae)
    V Kuete
    Department of Biochemistry, Faculty of Science, University of Dschang, P O BOX 67, Dschang, Cameroon
    J Ethnopharmacol 120:17-24. 2008
    ..FCB was found to be more active than FCR on most of the tested organisms. The results provided evidence that the studied plants extract, as well as some of the isolated compounds might be potential sources of new antimicrobial drug...
  36. ncbi Pharmacological and toxicological properties of Nigella sativa
    B H Ali
    Department of Veterinary Medicine, King Saud University, Buraydah, Al Gaseem 81999, Saudi Arabia
    Phytother Res 17:299-305. 2003
    ..It would appear that the beneficial effects of the use of the seeds and thymoquinone might be related to their cytoprotective and antioxidant actions, and to their effect on some mediators of inflammation...
  37. ncbi Antibacterial, anti-inflammatory, anti-cholinesterase and mutagenic effects of extracts obtained from some trees used in South African traditional medicine
    I M S Eldeen
    Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu Natal Pietermaritzburg, Scottsville, South Africa
    J Ethnopharmacol 102:457-64. 2005
    ..Of the 78 different plant extracts investigated, 80% showed activity against both Gram-positive and Gram-negative bacteria in the disc-diffusion ..
  38. ncbi Biological activities and distribution of plant saponins
    S G Sparg
    Research Centre for Plant Growth and Development, University of KwaZulu Natal, Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa
    J Ethnopharmacol 94:219-43. 2004
    ..Isolation studies of saponins were examined to determine which are the more commonly studied plant families and in which families saponins have been identified...
  39. ncbi Anti-fungal activity of crude extracts and essential oil of Moringa oleifera Lam
    Ping Hsien Chuang
    Institute of BioAgricultural Sciences, Academia Sinica, Taipei 115, Taiwan, ROC
    Bioresour Technol 98:232-6. 2007
    ..GC-MS analysis of the chemical composition of the essential oil from leaves showed a total of 44 compounds. Isolated extracts could be of use for the future development of anti-skin disease agents...
  40. ncbi Novel antiviral agents: a medicinal plant perspective
    S A A Jassim
    Department of Microbiology, Zayed Complex for Herbal Research and Traditional Medicine, General Authority for Health Services of Emirate of Abu Dhabi, Abu Dhabi, UAE
    J Appl Microbiol 95:412-27. 2003
    ..potentially useful medicinal plants and herbs waiting to be evaluated and exploited for therapeutic applications against genetically and functionally diverse viruses families such as Retroviridae, Hepadnaviridae and Herpesviridae..
  41. ncbi Anti-quorum sensing activity of medicinal plants in southern Florida
    Allison L Adonizio
    Department of Biological Sciences, Center for Ethnobiology and Natural Products, CENaP, Florida International University, 11200 SW 8th Street, University Park, Miami, 33199, USA
    J Ethnopharmacol 105:427-35. 2006
    ..Fagaceae). This study introduces not only a new mode of action and possible validation for traditional plant use, but also a potentially new therapeutic direction for the treatment of bacterial infections...
  42. ncbi Antifungal and antioxidative potential of oil and extracts derived from leaves of Indian spice plant Cinnamomum tamala
    A K Pandey
    Department of Biochemistry, University of Allahabad, Allahabad 211002 India
    Cell Mol Biol (Noisy-le-grand) 58:142-7. 2012
    ..tamala leaf extracts have potential to prevent growth of food spoilage/pathogenic fungi. In addition they also have capability to mitigate the oxidative stress by antioxidant response...
  43. pmc Withania somnifera reverses Alzheimer's disease pathology by enhancing low-density lipoprotein receptor-related protein in liver
    Neha Sehgal
    Division of Molecular and Cellular Neuroscience, National Brain Research Centre, Nainwal Mode, Manesar, Haryana 122050, India
    Proc Natl Acad Sci U S A 109:3510-5. 2012
    ..somnifera mediated through up-regulation of liver LRP indicates that targeting the periphery offers a unique mechanism for Aβ clearance and reverses the behavioral deficits and pathology seen in Alzheimer's disease models...
  44. ncbi Identification of bioactive compounds from flowers of black elder (Sambucus nigra L.) that activate the human peroxisome proliferator-activated receptor (PPAR) gamma
    Kathrine B Christensen
    Department of Food Science, Aarhus University, Kirstinebjergvej 10, Aarslev, Denmark
    Phytother Res 24:S129-32. 2010
    ..These findings suggest that flavonoid glycosides cannot activate PPARgamma, whereas some of their aglycones are potential agonists of PPARgamma...
  45. ncbi Cellular antioxidant activity (CAA) assay for assessing antioxidants, foods, and dietary supplements
    Kelly L Wolfe
    Department of Food Science, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 55:8896-907. 2007
    ..The CAA assay is a more biologically relevant method than the popular chemistry antioxidant activity assays because it accounts for some aspects of uptake, metabolism, and location of antioxidant compounds within cells...
  46. pmc Hypericum lanceolatum (Hypericaceae) as a potential source of new anti-malarial agents: a bioassay-guided fractionation of the stem bark
    Denis Zofou
    Biotechnology Unit, University of Buea, P O Box 63 Buea, South West Region, Cameroon
    Malar J 10:167. 2011
    ..A bioassay-guided fractionation was carried out in order to evaluate the anti-malarial potential and the safety of the methanol extract of the Hypericum lanceolatum stem bark...
  47. ncbi Aqueous extracts of the edible Gracilaria tenuistipitata are protective against H₂O₂-induced DNA damage, growth inhibition, and cell cycle arrest
    Jing Iong Yang
    Department of Seafood Science, National Kaohsiung Marine University, Kaohsiung 811, Taiwan
    Molecules 17:7241-54. 2012
    ..001). Taken together, these findings suggest that edible red algae Gracilaria water extract can prevent H₂O₂-induced oxidative DNA damage and its related cellular responses...
  48. ncbi Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention
    D Bagchi
    Department of Pharmaceutical and Administrative Sciences, Creighton University School of Pharmacy and Allied Health Professions, 2500 California Plaza, Omaha, NE 68178, USA
    Toxicology 148:187-97. 2000
    ..These results demonstrate that GSPE provides excellent protection against oxidative stress and free radical-mediated tissue injury...
  49. ncbi Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review
    L C Mishra
    Los Angeles College of Chiropractic LACC, 16200 E Amber Valley Dr, Whittier, CA 90609 1166
    Altern Med Rev 5:334-46. 2000
    ..Specifically, the literature was reviewed for articles pertaining to chemical properties, therapeutic benefits, and toxicity...
  50. ncbi Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial
    Karin Ried
    Discipline of General Practice, School of Population Health and Clinical Practice, The University of Adelaide, Adelaide, South Australia 5005, Australia
    Maturitas 67:144-50. 2010
    ..To assess the effect, tolerability and acceptability of aged garlic extract as an adjunct treatment to existing antihypertensive medication in patients with treated, but uncontrolled, hypertension...
  51. ncbi Antioxidant and antiproliferative activities of common vegetables
    Yi Fang Chu
    Department of Food Science and Institute of Comparative and Environmental Toxicology, Cornell University, Ithaca, New York 14853, USA
    J Agric Food Chem 50:6910-6. 2002
    ..The BI could be a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion...
  52. ncbi Antioxidant activity of apple peels
    Kelly Wolfe
    Institute of Comparative and Environmental Toxicology and Department of Food Science, Stocking Hall, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 51:609-14. 2003
    ..The high content of phenolic compounds, antioxidant activity, and antiproliferative activity of apple peels indicate that they may impart health benefits when consumed and should be regarded as a valuable source of antioxidants...
  53. ncbi Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding time
    Keun Ho Ryu
    Pharmacology Team, Life Science R and D Center, SK Chemicals, Korea
    Thromb Res 124:328-34. 2009
    ..With these studies, we suggest that combinative therapy of GB and cilostazol might offer enhanced anti-thrombotic efficacies without increasing side-effects...
  54. ncbi Ginkgo biloba extract attenuates oxLDL-induced oxidative functional damages in endothelial cells
    Hsiu Chung Ou
    Division of Endocrinology and Metabolism, Dept of Internal Medicine, Taichung Veterans General Hospital, No 160, Sec 3, Taichung Kang Road, Taichung 407, Taiwan
    J Appl Physiol (1985) 106:1674-85. 2009
    ..05). Results from this study may provide insight into a possible molecular mechanism underlying GbE suppression of the oxLDL-mediated vascular endothelial dysfunction...
  55. ncbi Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit
    Ammar Saleem
    Department of Chemistry, University of Turku, Kiinamyllynkatu 10, FIN 20014 Turku, Finland
    J Ethnopharmacol 81:327-36. 2002
    ..Chebulinic acid (IC(50) = 53.2 microM +/- 0.16) > tannic acid (IC(50) = 59.0 microg/ml +/- 0.19) > and ellagic acid (IC(50) = 78.5 microM +/- 0.24), were the most growth inhibitory phenolics of T. chebula fruit in our study...
  56. pmc Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants
    Alexander D Crawford
    Department of Pharmaceutical Sciences, University of Leuven, Leuven, Belgium
    PLoS ONE 6:e14694. 2011
    ..Bioactivity screening of East African medicinal plant extracts using fli-1:EGFP transgenic zebrafish embryos identified Oxygonum sinuatum and Plectranthus barbatus as ..
  57. ncbi Potential of medicinal plants from the Brazilian semi-arid region (Caatinga) against Staphylococcus epidermidis planktonic and biofilm lifestyles
    Danielle Da Silva Trentin
    Faculdade de Farmacia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    J Ethnopharmacol 137:327-35. 2011
    ..The aim of this study was to investigate the antibiofilm and antibacterial activities of 45 aqueous extracts from 24 Caatinga plant species...
  58. pmc Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus
    Sumana Dakeng
    Mahidol University, Bangkok, Thailand
    J Cell Biochem 113:49-60. 2012
    ..Our data suggest that cucurbitacin B may in part induce apoptosis and exert growth inhibitory effect via interruption the Wnt signaling...
  59. ncbi Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds
    Marjan Nassiri Asl
    Department of Pharmacology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, IR Iran
    Phytother Res 22:709-24. 2008
    ..This review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical and adverse effects of licorice and its bioactive components...
  60. ncbi Effect of extraction solvent/technique on the antioxidant activity of selected medicinal plant extracts
    Bushra Sultana
    Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad 38040, Pakistan
    Molecules 14:2167-80. 2009
    ..Although higher extract yields were obtained by the refluxing extraction technique, in general higher amounts of total phenolic contents and better antioxidant activity were found in the extracts prepared using a shaker...
  61. ncbi Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): a review of recent research
    Badreldin H Ali
    Department of Pharmacology and Clinical Pharmacy, College of Medicine and Health Sciences, Sultan Qaboos University, P O Box 35, Al Khod 123, Oman
    Food Chem Toxicol 46:409-20. 2008
    ..More studies are required in animals and humans on the kinetics of ginger and its constituents and on the effects of their consumption over a long period of time...
  62. pmc Isolation and analysis of ginseng: advances and challenges
    Lian Wen Qi
    Tang Center for Herbal Medicine Research and Department of Anesthesia and Critical Care, The Pritzker School of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    Nat Prod Rep 28:467-95. 2011
    ..The aim of this review is to illustrate the recent advances in the isolation and analysis of ginseng, and to highlight new applications and challenges. Emphasis is placed on recent trends and emerging techniques...
  63. ncbi Antimicrobial activity of five herbal extracts against multi drug resistant (MDR) strains of bacteria and fungus of clinical origin
    Rosina Khan
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India
    Molecules 14:586-97. 2009
    ..The most potent antimicrobial plant was A. nilotica (MIC range 9.75-313 microg/ml), whereas other crude plant extracts studied in this report were found to exhibit higher MIC values than A...
  64. ncbi Biological synthesis of triangular gold nanoprisms
    S Shiv Shankar
    Materials Chemistry, National Chemical Laboratory, Pune 411 008, India
    Nat Mater 3:482-8. 2004
    ..The anisotropy in nanoparticle shape results in large near-infrared absorption by the particles, and highly anisotropic electron transport in films of the nanotriangles...
  65. ncbi Aphrodisiac properties of Tribulus Terrestris extract (Protodioscin) in normal and castrated rats
    K Gauthaman
    Department of Obstetrics and Gynaecology, National University Hospital, National University of Singapore, Singapore 119704, Singapore
    Life Sci 71:1385-96. 2002
    ..These results were statistically significant. It is concluded that TT extract appears to possess aphrodisiac activity probably due to androgen increasing property of TT (observed in our earlier study on primates)...
  66. ncbi Anticancer and immunostimulatory compounds from Andrographis paniculata
    R Ajaya Kumar
    Discovery Research, Dr Reddy s Laboratories, Miyapur, Hyderabad 500050, India
    J Ethnopharmacol 92:291-5. 2004
    ..Andrographolide showed anticancer activity on diverse cancer cells representing different types of human cancers. Whereas all the three molecules showed enhanced proliferation and interleukin-2 (IL-2) induction in HPBLs...
  67. ncbi Pharmacological actions and potential uses of Momordica charantia: a review
    J K Grover
    Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110049, India
    J Ethnopharmacol 93:123-32. 2004
    ..There are few reports available on clinical use of MC in diabetes and cancer patients that have shown promising results...
  68. ncbi Carbon tetrachloride-induced nephrotoxicity in rats: protective role of Digera muricata
    Muhammad R Khan
    Department of Biochemistry, Faculty of Biological Sciences, Quaid i Azam University, Islamabad 4400, Pakistan
    J Ethnopharmacol 122:91-9. 2009
    ....
  69. ncbi A green tea extract high in catechins reduces body fat and cardiovascular risks in humans
    Tomonori Nagao
    Health Care Food Research Laboratories, Kao Corporation, 2 1 3, Bunka, Sumida ku, Tokyo, 131 8501, Japan
    Obesity (Silver Spring) 15:1473-83. 2007
    ..The body fat reducing effect and reduction of risks for cardiovascular disease by a green tea extract (GTE) high in catechins was investigated in humans with typical lifestyles...
  70. ncbi Ginger--an herbal medicinal product with broad anti-inflammatory actions
    Reinhard Grzanna
    RMG Biosciences, Inc
    J Med Food 8:125-32. 2005
    ..Such preparations will be useful for studies in experimental animals and humans...
  71. ncbi A review of natural products with antileishmanial activity
    L G Rocha
    Departamento de Microbiologia e Parasitologia, Universidade Federal do Rio Grande do Norte, 59000 000 Natal, RN, Brazil
    Phytomedicine 12:514-35. 2005
    ..The present work constitutes a review of the literature on plant extracts and chemically defined molecules of natural origin showing antileishmanial activity...
  72. ncbi Simultaneous determination of multiple phytohormones in plant extracts by liquid chromatography-electrospray tandem mass spectrometry
    Abhilasha Durgbanshi
    Departamento de Ciencias Experimentales, Universitat Jaume I, Campus Riu Sec, E 12071 Castelló, Spain
    J Agric Food Chem 53:8437-42. 2005
    ..This method represents a clear advantage because it extensively reduces sample preparation and total time for routine analysis of phytohormones in real plant samples...
  73. ncbi Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract
    S Prathap Chandran
    Nanoscience Group, Materials Chemistry Division, Biochemical Sciences Division, National Chemical Laboratory, Pune 411008, India
    Biotechnol Prog 22:577-83. 2006
    ..Reduction of silver ions by Aloe vera extract however, led to the formation of spherical silver nanoparticles of 15.2 nm +/- 4.2 nm size...
  74. ncbi Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells
    Béatrice Romier-Crouzet
    Biochimie Cellulaire, Nutritionnelle et Toxicologique, Institut des Sciences de la Vie, Universite Catholique de Louvain, Croix du Sud, 5, B 1348 Louvain la Neuve, Belgium
    Food Chem Toxicol 47:1221-30. 2009
    ..6 (P<0.0001) and 2.2-fold (P=0.001), respectively. We suggest that pomegranate extract could be particularly promising in dietary prevention of intestinal inflammation...
  75. ncbi Geranium leaf assisted biosynthesis of silver nanoparticles
    S Shiv Shankar
    Materials Chemistry Division, National Chemical Laboratory, Pune 411 008, India
    Biotechnol Prog 19:1627-31. 2003
    ..This study also represents an important advance in the use of plants over microorganisms in the biosynthesis of metal nanoparticles...
  76. ncbi Free radical scavenging properties of wheat extracts
    Liangli Yu
    Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado 80523, USA
    J Agric Food Chem 50:1619-24. 2002
    ..The TPC were 487.9 +/- 927.8 microg gallic acid equivalents/g of grain. No correlation was observed between TPC and radical scavenging capacities for DPPH* and ABTS*+ (p = 0.15 and p > 0.5, respectively)...
  77. ncbi A study of the minimum inhibitory concentration and mode of action of oregano essential oil, thymol and carvacrol
    R J Lambert
    Unilever Research Colworth, SEAC-Microbiology, Sharnbrook, Bedfordshire, UK
    J Appl Microbiol 91:453-62. 2001
    ..OF THE STUDY: The knowledge of extent and mode of inhibition of specific compounds, which are present in plant extracts, may contribute to the successful application of such natural preservatives in foods, since certain ..
  78. ncbi Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component
    Anoja S Attele
    Tang Center for Herbal Medicine Research, The Pritzker School of Medicine, University of Chicago, Chicago, Illinois 60637, USA
    Diabetes 51:1851-8. 2002
    ..This antidiabetic effect of ginsenoside Re was not associated with body weight changes, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism...
  79. ncbi Plants and human health in the twenty-first century
    Ilya Raskin
    Biotech Center, Foran Hall, 59 Dudley Road, Cook College, Rutgers University, New Brunswick, NJ 08901 8520, USA
    Trends Biotechnol 20:522-31. 2002
    ..This review discusses the history, future, scientific background and regulatory issues related to botanical therapeutics...
  80. ncbi Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line
    Primchanien Moongkarndi
    Department of Microbiology, Faculty of Pharmacy, Mahidol University, Sri Ayudthaya Road, Rajdhevee, Bangkok 10400, Thailand
    J Ethnopharmacol 90:161-6. 2004
    ..Thus, it indicates that this substance can show different activities and has potential for cancer chemoprevention which were dose dependent as well as exposure time dependent...
  81. ncbi Antioxidant activity of propolis: role of caffeic acid phenethyl ester and galangin
    A Russo
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, V le A Doria 6, 95125, Catania, Italy
    Fitoterapia 73:S21-9. 2002
    ..CAPE, used alone, exhibited a strong antioxidant activity, higher than galangin. The experimental evidence, therefore, suggests that CAPE plays an important role in the antioxidant activity of propolis...
  82. ncbi Antioxidant and antiproliferative activities of common fruits
    Jie Sun
    Department of Food Science, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 50:7449-54. 2002
    ..A bioactivity index (BI) for dietary cancer prevention is proposed to provide a new alternative biomarker for future epidemiological studies in dietary cancer prevention and health promotion...
  83. ncbi Phytoalexins from the Vitaceae: biosynthesis, phytoalexin gene expression in transgenic plants, antifungal activity, and metabolism
    Philippe Jeandet
    Laboratoire d Oenologie, URVVC, UPRES EA 2069, Faculte des Sciences, Universite de Reims, B P 1039, 51687 Reims Cedex 02, France
    J Agric Food Chem 50:2731-41. 2002
    ....
  84. ncbi Dietary polyphenols, inflammation, and cancer
    Weimin Guo
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Nutr Cancer 61:807-10. 2009
    ..This review summarizes the effect of polyphenols on inflammation and cancer; avenanthramides, a unique polyphenol from oats, are especially focused...
  85. ncbi Ginkgo biloba extract inhibits tumor necrosis factor-alpha-induced reactive oxygen species generation, transcription factor activation, and cell adhesion molecule expression in human aortic endothelial cells
    Jaw Wen Chen
    National Yang Ming University School of Medicine, Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China
    Arterioscler Thromb Vasc Biol 23:1559-66. 2003
    ....
  86. ncbi Therapeutic applications of pomegranate (Punica granatum L.): a review
    Julie S Jurenka
    Thorne Research, PO Box 25, Dover, ID 83825, USA
    Altern Med Rev 13:128-44. 2008
    ..Other potential applications include infant brain ischemia, male infertility, Alzheimer's disease, arthritis, and obesity...
  87. ncbi Antimicrobial activity of 10 different plant polyphenols against bacteria causing food-borne disease
    Toshitsugu Taguri
    Nagasaki Prefectural Institute of Public Health and Environmental Sciences, Japan
    Biol Pharm Bull 27:1965-9. 2004
    ..aureus (98-389 microg/ml) and the genus Vibrio (68-488 microg/ml) were similar. The relatively lower mean MIC values of 1, 2, 5, and 6 suggest the importance of 3,4,5-trihydroxyphenyl groups in antibacterial activity...
  88. ncbi Immature Citrus sunki peel extract exhibits antiobesity effects by β-oxidation and lipolysis in high-fat diet-induced obese mice
    Seong Il Kang
    Department of Biology, Jeju National University, Korea
    Biol Pharm Bull 35:223-30. 2012
    ..These results suggest that CSE had an antiobesity effect via elevated β-oxidation and lipolysis in adipose tissue...
  89. pmc Medicinal plants used by traditional healers in Kancheepuram district of Tamil Nadu, India
    Chellaiah Muthu
    Entomology Research Institute, Loyola College, Chennai 600 034, India
    J Ethnobiol Ethnomed 2:43. 2006
    ..The traditional healers are dwindling in number and there is a grave danger of traditional knowledge disappearing soon since the younger generation is not interested to carry on this tradition...
  90. ncbi Antioxidant and hepatoprotective effect of Acanthus ilicifolius
    B H Babu
    Amala Cancer Research Centre, Amala Nagar, 680 553, Thrissur, India
    Fitoterapia 72:272-7. 2001
    ..These results were comparable with those obtained with curcumin (100 mg/kg, p.o.)...
  91. ncbi Alternative therapies for the prevention and treatment of osteoporosis
    Jameela Banu
    Division of Clinical Immunology and Rheumatology, Department of Medicine, San Antonio, Texas, USA
    Nutr Rev 70:22-40. 2012
    ..The present review discusses the most promising findings from studies of these plant families...
  92. ncbi Antiviral activities of extracts and selected pure constituents of Ocimum basilicum
    Lien Chai Chiang
    Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan
    Clin Exp Pharmacol Physiol 32:811-6. 2005
    ..5. With SI values greater than 200, the potential use of ursolic acid for treating infection with CVB1 and EV71 merits further investigation...
  93. ncbi Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles
    M Abidov
    Institute of Immunopathology, Russian Academy of Natural Sciences, Moscow
    Bull Exp Biol Med 136:585-7. 2003
    ..Experiments proved different pharmacological characteristics of R. rosea and R. crenulata: R. rosea is most effective for improving physical working capacity...
  94. pmc Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa PAO1 by Ayurveda spice clove (Syzygium aromaticum) bud extract
    Thiba Krishnan
    Division of Genetics and Molecular Biology, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
    Sensors (Basel) 12:4016-30. 2012
    ..This study shows that the presence of natural compounds that exhibit anti-quorum sensing activity in the clove extracts may be useful as the lead of anti-infective drugs...
  95. ncbi Metabolic and molecular action of Trigonella foenum-graecum (fenugreek) and trace metals in experimental diabetic tissues
    Najma Zaheer Baquer
    School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India
    J Biosci 36:383-96. 2011
    ..Our findings illustrate and elucidate the antidiabetic/insulin mimetic effects of Trigonella, manganese and vanadium...
  96. ncbi Efficacy of a comfrey root extract ointment in comparison to a diclofenac gel in the treatment of ankle distortions: results of an observer-blind, randomized, multicenter study
    H G Predel
    Merck Selbstmedikation GmbH, Roesslerstr 96, D 64293 Darmstadt, Germany
    Phytomedicine 12:707-14. 2005
    ..01-103.09h*N/cm2 and was completely above the margin of non-inferiority. Moreover, the results of the primary and secondary variables indicate that Comfrey extract may be superior to Diclofenac gel...
  97. ncbi Medicinal properties of Echinacea: a critical review
    B Barrett
    Department of Family Medicine, University of Wisconsin Medical School, Madison WI 53715, USA
    Phytomedicine 10:66-86. 2003
    ..Hence, while there is a great deal of moderately good-quality scientific data regarding E. purpurea, effectiveness in treating illness or in enhancing human health has not yet been proven beyond a reasonable doubt...
  98. ncbi Antioxidant health effects of aged garlic extract
    C Borek
    Department of Community Health and Family Medicine, Nutrition and Infectious Diseases Unit, Tufts University School of Medicine, Boston, MA 02111, USA
    J Nutr 131:1010S-5S. 2001
    ..e., reducing the risk of cardiovascular disease, stroke, cancer and aging, including the oxidant-mediated brain cell damage that is implicated in Alzheimer's disease...
  99. ncbi Chemical analysis of Ginkgo biloba leaves and extracts
    Teris A van Beek
    Laboratory of Organic Chemistry, Phytochemical Section, Wageningen University, The Netherlands
    J Chromatogr A 967:21-55. 2002
    ..Lately a there is a lot of interest in the analysis of the undesired alkylphenols and a few validated procedures have been published. The analysis of Ginkgo proanthocyanidins is still in its infancy and no reliable assays exist...
  100. ncbi Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1
    Takumi Satoh
    Department of Welfare Engineering, Faculty of Engineering, Iwate University, Morioka, Iwate, Japan
    J Neurochem 104:1116-31. 2008
    ....
  101. ncbi Antioxidant, antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.)
    Ilhami Gulcin
    Department of Chemistry, Faculty of Science and Arts, Ataturk University, 25240 Erzurum, Turkey
    J Ethnopharmacol 90:205-15. 2004
    ..WEN also showed antimicrobial activity against nine microorganisms, antiulcer activity against ethanol-induced ulcerogenesis and analgesic effect on acetic acid-induced stretching...

Research Grants62

  1. Impact of cholinergic plant extracts on nociception
    ERIC WIERTELAK; Fiscal Year: 2005
    ..Solenace plant extracts will be produced and analyzed to identify and quantify alkaloids and to determine dose-response ..
  2. Plant-Derived Estrogens and Cell Proliferation
    Emma Shtivelman; Fiscal Year: 2011
    ..To test this hypothesis, we screened over 50 plant extracts used in Traditional Chinese Medicine for tissue selective ERa activity...
  3. Discovery of Novel Anti-Inflammatory Phytochemicals on Human Cell Platforms
    ERIK MILLS SCHWIEBERT; Fiscal Year: 2010
    ..parental and fractionated extracts derived from botanicals and purified small molecule phytochemicals from plant extracts provided by CDex...
  4. Neuroprotective Effect of Ginkgo Biloba and its Bioactive Components Ischemia
    Zahoor Ahmad Shah; Fiscal Year: 2012
    ..I have used both of these methods to test the beneficial properties of other well standardized herbal plant extracts and their bioactive components against stroke...
  5. Biomodification of Dentin Matrix Structure
    Ana Karina B Bedran-Russo; Fiscal Year: 2013
    ..Preliminary studies provide strong support for nature-derived agents, in particular polyphenol-rich plant extracts, which strongly enhance dentin matrix properties and positively impact the dentin-resin bonds...
  6. Novel Antitumor Agents
    Kuo Hsiung Lee; Fiscal Year: 2013
    ..bioactivity-directed fractionation and isolation to identify breast cancer-selective compounds starting from plant extracts with confirmed activity and counter-screened in-house on the basis of susceptibility to breast cancer cell ..
  7. Efficacy evaluation of traditionally used antimalarial plants
    ROCKY T GRAZIOSE; Fiscal Year: 2012
    ..and elucidate the composition, chemical identity, and bioactivity of fractions and compounds from antimalarial plant extracts with the highest in vitro activity and low toxicity...
  8. Identification of Novel Plant-derived Antimalarial Compounds
    Susan L Mooberry; Fiscal Year: 2012
    ..R21 proposal aims to isolate, identify and further characterize the active components of these four validated plant extracts and an additional 10 extracts that will be selected from secondary screening of 46 additional crude extracts ..
  9. Bioactive Compounds from the Biodiversity of Vietnam and Laos
    Djaja D Soejarto; Fiscal Year: 2010
    ..of Nui Chua National Park NCNP (Vietnam), marine biodiversity of South China Sea, and UIC-ICBG Phase II legacy plant extracts;(ii) discovery of new cellulose-degrading and biofuel-producing microbial strains;(iii) advancing new ..
  10. Drug Discovery for Mental Disorders: Preclinical Studies of Peruvian Botanicals
    ABRAHAM JAIME VAISBERG; Fiscal Year: 2013
    ..About {20%} of these plant extracts have been screened so far to validate its traditional medical use with behavioral tests in mice...
  11. CENTER FOR RESEARCH ON BOTANICAL DIETARY SUPPLEMENTS
    DIANE FEICKERT BIRT; Fiscal Year: 2010
    ..supplements, scientific studies to understand the biological properties of the compounds present in these plant extracts are limited and efficacy of many of the supplements is unclear...
  12. Saw palmetto and Pygeum africanum on BPH Progression
    Kevin T McVary; Fiscal Year: 2010
    ..Increasing attention has been paid to plant extracts (or phytotherapy) use by patients to self-treat medical ailments such as BPH...
  13. CAMs as counter measures against infectious and inflammatory disease
    Mark A Jutila; Fiscal Year: 2012
    ..study of CAM effects on innate leukocytes and epithelial cells, purification of defined agonists from crude plant extracts, use of probiotic CAMs, and use of rodent models of infectious and inflammatory disease to define specific ..
  14. Serotonergic Botanicals for Menopausal Treatment
    SHARLA POWELL; Fiscal Year: 2009
    ..Ms. Powell's main goal will be to investigate a variety of plant extracts and active compounds to evaluate their serotonergic activity ...
  15. Rescue of CFTR-deltaF508 misfolding by pharmacological and genetic suppressors
    RYAN TYLER; Fiscal Year: 2009
    ..system is exemplified in a preliminary HTS study, in which we identified a novel small molecule derived from plant extracts that rescues CFTRdeltaF508 misfolding...
  16. Cancer Prevention by West African Medicinal Plants
    Michael Wargovich; Fiscal Year: 2007
    ..The specific aims of this project are: 1) To develop chemical fingerprints of five West African plant extracts (neem tree, baobab tree, Senegal mahogany, African basil, and kinkirissi bush) as initial quality control ..
  17. NONCARIOGENIC INTENSE NATURAL SWEETNERS
    ALAN KINGHORN; Fiscal Year: 1993
    ..b>Plant extracts and chromatographic fractions will be monitored for sweetness using previously established gerbil ..
  18. Potential New Breast Cancer Drugs from Tropical Plants
    DEBRA MORIARITY; Fiscal Year: 2003
    ..aims are (1) Use a 96-well cytotoxicity assay against a panel of selected breast cancer cell lines to screen plant extracts for those with potent inhibition or killing of cells; (2) Use an innovative high-throughput genetic-based ..
  19. PLANT ANTITUMOR AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2009
    ..1) Bioactivity-directed fractionation and isolation of the active principles from 30 high priority plant extracts will be continued...
  20. Drug Development and Biocultural Diversity Conservation
    Paul Cox; Fiscal Year: 2004
    ..Micro-organisms will also be isolated from these materials and screened for antinfective activity. To screen plant extracts and compounds derived from terrestrial and marine environments for anti-infective, CNS, anti-cancer, ..
  21. A New Multi-Constituent Mode of Action for Goldenseal (Hydrastis canadensis)
    NADJA CECH; Fiscal Year: 2009
    ..Expertise of the research team in the characterization of complex plant extracts using mass spectrometry will be essential to accomplishing this goal...
  22. Synergy in Immunomodulation by Spilanthes and Echinacea
    NADJA CECH; Fiscal Year: 2003
    ..To test this hypothesis, plant extracts of varying polarity will be prepared from Echinacea purpurea and Spilanthes acmella plant material that has ..
  23. Neuroprotective Effect of Ginkgo Biloba and its Bioactive Components Ischemia
    ZAHOOR SHAH; Fiscal Year: 2009
    ..I have used both of these methods to test the beneficial properties of other well standardized herbal plant extracts and their bioactive components against stroke...
  24. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..Our plan of attack in this proposal is: (a) to screen our collection of tropical rainforest plant extracts for killing of the parasites in culture, (b) to test our extracts for inhibition of some key enzymes necessary ..
  25. High Throughput Profiling of Plant Extracts Using Engineered Heart Tissues
    Tetsuro Wakatsuki; Fiscal Year: 2006
    ..After confirming the usefulness and reproducibility of the assay, we will profile a small library of plant extracts from the Philippines...
  26. NOVEL INHIBITORS OF DNA TOPOISOMERASE II
    Kuo Hsiung Lee; Fiscal Year: 1993
    ..assays of cytotoxicity in human KB cell lines resistant to topoisomerase II inhibitors for selection of plant extracts and assays for protein-linked DNA breaks (PLDB), inhibition of etoposide (VP-16)-induced PLDB and inhibition ..
  27. SOURCES OF NEUROACTIVE ANALGESIC N-ACYLETHANOLAMINES
    Kent Chapman; Fiscal Year: 2002
    ..chromatography coupled with mass spectrometry) were developed to identify these lipid metabolites in crude plant extracts and in industrially-refined vegetable oil fractions...
  28. West African HIV Drug Screening Capacity
    LOUIS BARROWS; Fiscal Year: 2002
    ..A non-infectious whole HI V-virus replication assay will be employed to test plant extracts for anti-HIV activity, and to guide the isolation of the active components...
  29. ENANTIOSELECTIVE APPROACH TO ANTITUMOR AGENTS
    JAMES PANEK; Fiscal Year: 1992
    ..approach to the chemical synthesis of (+)- sesbanimide A (3), a potent cytotoxic agent isolated from plant extracts of Sesbania drummundii seed, and six structurally related analogues is proposed...
  30. DEVELOPMENT FOR DSB, A NOVEL POTENT HIV INHIBITOR
    Graham Allaway; Fiscal Year: 2002
    ..H. Lee of the University of North Carolina at Chapel Hill to discover such compounds by screening plant extracts for HIV inhibitors, then designing synthetic analogs with improved antiviral and solubility properties...
  31. STRUCTURAL STUDIES OF ENOLATES FOR ORGANIC SYNTHESIS
    PAUL WILLIARD; Fiscal Year: 1992
    ..While the source of these compounds is from plant extracts, a suitable synthetic route would be preferable| The work outlined herein will greatly assist with the ongoing ..
  32. Synthesis of Natural and Unnatural Inhibitors of ftsZ
    JARED SHAW; Fiscal Year: 2006
    ..These natural products are derived from plant extracts that are currently used for traditional medicine, so it is likely that there mammalian toxicity is quite low...
  33. INVESTIGATIONS OF CANNABIS PLANT AND SMOKE CONSTITUENTS
    Milos Novotny; Fiscal Year: 1980
    Work will be continued to characterize chemically various fractions and subfractions of cannabis plant extracts and smoke condensates. Comparative studies are simultaneously carried out with tobacco as a "baseline material"...
  34. RNA-Targeted Antimicobial Agents
    JING SHEN DENG; Fiscal Year: 2003
    ..A screen of 3200 plant extracts led to the identification of seven active principles, none of which had previously been shown to affect the ..
  35. Discovery/Development of Anticancer Agents from Plants
    Frederick Valeriote; Fiscal Year: 2007
    ..of anticancer agents active against the major solid tumors of man During the past 5 years, nearly 4000 crude plant extracts, from the laboratory of Dr Joseph Hoffmann at the University of Arizona, have been evaluated for solid tumor ..
  36. CANDIDA SECRETED ASPARTIC PROTEASES AS DRUG TARGETS
    ALICE CLARK; Fiscal Year: 2000
    ..The aims are to develop rapid screening procedures of Candida proteases from plant sources, evaluate plant extracts for protease inhibition, isolate and structurally characterize inhibitors from active plant extracts, ..
  37. IN VITRO BIOASSAY FOR ESTROGENS AND ANTIESTROGENS
    DAVID ZAVA; Fiscal Year: 1991
    ..It will provide a simple means by which a large panel of drugs, plant extracts, foodstuffs, etc. can be screened rapidly for estrogenic or antiestrogenic (ie, anticancer) activity...
  38. OBESE FEMALE RESTRAINED EATERS : TWO TREATMENT OPTIONS
    Judith Stern; Fiscal Year: 2002
    ..A manual of procedures will be generated to assist others in replicating the intervention. ..
  39. Magnesium and Asthma - Clinical Trials
    Judith Stern; Fiscal Year: 2004
    ..We do not anticipate that Mg supplementation will replace conventional treatment, but may complement and decrease the need for conventional medications. ..
  40. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
    ..This information may also be useful for therapeutic research investigating the potential use of mGluR ligands in age-related neurodegenerative disorders, such as Alzheimer's disease. ..
  41. Potential anti-relapse drugs: a plant genomics approach
    John Littleton; Fiscal Year: 2004
    ..In phase 3, potential products will be commercialized with a partner specializing in pharmaceutical natural products. ..
  42. Enhancing axon regeneration by multi-inhibitor blocking
    RONALD SCHNAAR; Fiscal Year: 2005
    ..The resulting data may provide insight on the relative contributions of the different ARI's in an in vivo model, and may support evaluation of new approaches to enhance axon regeneration after CNS injury. ..
  43. COMPLEX CARBOHYDRATES IN NEURONAL CELL FUNCTION
    RONALD SCHNAAR; Fiscal Year: 2004
    ....
  44. Identification of Anti-Viral Compounds from Plants
    Shiyou Li; Fiscal Year: 2005
    ..abstract_text> ..
  45. Novel estrogen receptor ligands from plant genomics
    John Littleton; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  46. Methodology of Phase I and II trials of anticancer CAM
    Andrew Vickers; Fiscal Year: 2004
    ....
  47. Conference on Emerging Research Technologies
    Gail Mahady; Fiscal Year: 2004
    ....
  48. Application of plant genomics to alcoholic brain damage
    John Littleton; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  49. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  50. EVALUATION OF BOTANICALS FOR H .PYLORI INFECTIONS
    Gail Mahady; Fiscal Year: 2002
    ..pylori strains. Active extracts will be utilized for in vivo studies. The long-term objectives are to develop safe and effective botanical extracts for the treatment and prevention of H. pylori infections. ..
  51. DEVELOPMENT OF SCREENS FOR DRUGS IN ALCOHOL DEPENDENCE
    John Littleton; Fiscal Year: 2007
    ..abstract_text> ..
  52. MECHANISMS OF NEURODEGENERATION AND REGENERATION IN POST-STROKE SURVIVORS
    Raj Kalaria; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. DNA and Phytochemical Fingerprinting of Actaea Species
    Edward Kennelly; Fiscal Year: 2007
    ..Our long-range goals are to improve the quality of black cohosh dietary supplements and understand the variation in Actaea species. ..
  54. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  55. ENVIRONMENTAL LIGHT AND RETINAL MEMBRANE DEVELOPMENT
    Daniel Organisciak; Fiscal Year: 2003
    ..In addition, the time course of the appearance of cytoplasmic cytochrome C and the activation of cellular caspases will be determined by antibody-based techniques, immunocytochemistry and enzymatic analysis. ..
  56. PREVENTION OF COLORECTAL CANCER BY iNOS AND COX-2 SELECTIVE INHIBITORS
    CHINTHALAPALLY RAO; Fiscal Year: 2008
    ..abstract_text> ..
  57. Metabolome of non-replicating M. tuberculosis
    GUIDO PAULI; Fiscal Year: 2003
    ..abstract_text> ..