excipients

Summary

Summary: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.

Top Publications

  1. ncbi Review: physical chemistry of solid dispersions
    Sandrien Janssens
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pharm Pharmacol 61:1571-86. 2009
  2. pmc Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates
    Vasco Filipe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300, RA, Leiden, The Netherlands
    Pharm Res 27:796-810. 2010
  3. ncbi The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations
    Jagdeep Shur
    Pharmaceutical Surface Science Group, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Pharm Res 25:1631-40. 2008
  4. ncbi High-throughput screening of excipients intended to prevent antigen aggregation at air-liquid interface
    Sébastien Dasnoy
    Louvain Drug Research Institute, Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue E Mounier 73, UCL 7320, 1200, Brussels, Belgium
    Pharm Res 28:1591-605. 2011
  5. ncbi The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    J D Andya
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 16:350-8. 1999
  6. ncbi Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
    Kanchan Kohli
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India
    Drug Discov Today 15:958-65. 2010
  7. pmc Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
  8. ncbi Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets
    A Khairuzzaman
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, University Plaza, Brooklyn, NY 11201, USA
    Int J Pharm 318:15-21. 2006
  9. ncbi Toxic additives in medication for preterm infants
    A Whittaker
    Department of Infection, Immunity and Inflammation, University of Leicester Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Arch Dis Child Fetal Neonatal Ed 94:F236-40. 2009
  10. ncbi Stability of lipid excipients in solid lipid nanoparticles
    Anna Radomska-Soukharev
    K Marcinkowski University of Medical Sciences, Department of Pharmaceutical Technology, 6 Grunwaldzka, 60 780 Poznan, Poland
    Adv Drug Deliv Rev 59:411-8. 2007

Detail Information

Publications330 found, 100 shown here

  1. ncbi Review: physical chemistry of solid dispersions
    Sandrien Janssens
    Laboratorium voor Farmacotechnologie en Biofarmacie, Katholieke Universiteit Leuven, Leuven, Belgium
    J Pharm Pharmacol 61:1571-86. 2009
    ..Nevertheless, some issues have to be considered regarding thermodynamic instability, as well in supersaturated solutions that are formed upon dissolution as in the solid state...
  2. pmc Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates
    Vasco Filipe
    Division of Drug Delivery Technology, Leiden Amsterdam Center for Drug Research, Leiden University, P O Box 9502, 2300, RA, Leiden, The Netherlands
    Pharm Res 27:796-810. 2010
    ..To evaluate the nanoparticle tracking analysis (NTA) technique, compare it with dynamic light scattering (DLS) and test its performance in characterizing drug delivery nanoparticles and protein aggregates...
  3. ncbi The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations
    Jagdeep Shur
    Pharmaceutical Surface Science Group, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Pharm Res 25:1631-40. 2008
    ..To investigate the role of in situ generated fine excipient particles on the fluidization and aerosolization properties of dry powder inhaler (DPI) formulations...
  4. ncbi High-throughput screening of excipients intended to prevent antigen aggregation at air-liquid interface
    Sébastien Dasnoy
    Louvain Drug Research Institute, Universite Catholique de Louvain, Unite de Pharmacie Galenique, Avenue E Mounier 73, UCL 7320, 1200, Brussels, Belgium
    Pharm Res 28:1591-605. 2011
    ..with low protein concentrations, as present in vaccines, in order to evaluate the performance of various excipients in preventing the aggregation at air-liquid interface of an experimental recombinant antigen called Antigen 18A.
  5. ncbi The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    J D Andya
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 16:350-8. 1999
    ..To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized monoclonal antibody...
  6. ncbi Self-emulsifying drug delivery systems: an approach to enhance oral bioavailability
    Kanchan Kohli
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 62, India
    Drug Discov Today 15:958-65. 2010
    ....
  7. pmc Microbicide excipients can greatly increase susceptibility to genital herpes transmission in the mouse
    Thomas R Moench
    ReProtect, Inc, Baltimore, MD 21286 USA
    BMC Infect Dis 10:331. 2010
    ..In addition, "inactive ingredients" (or excipients) used in topical products to formulate and deliver the active ingredient might also cause epithelial toxicities ..
  8. ncbi Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets
    A Khairuzzaman
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, University Plaza, Brooklyn, NY 11201, USA
    Int J Pharm 318:15-21. 2006
    ..Contrary to the first-order release profile of all the drugs from the MC matrix tablets, a zero-order release was obtained from the MC-GA matrix tablets in water...
  9. ncbi Toxic additives in medication for preterm infants
    A Whittaker
    Department of Infection, Immunity and Inflammation, University of Leicester Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Arch Dis Child Fetal Neonatal Ed 94:F236-40. 2009
    Little is known about exposure of preterm infants to excipients during routine clinical care.
  10. ncbi Stability of lipid excipients in solid lipid nanoparticles
    Anna Radomska-Soukharev
    K Marcinkowski University of Medical Sciences, Department of Pharmaceutical Technology, 6 Grunwaldzka, 60 780 Poznan, Poland
    Adv Drug Deliv Rev 59:411-8. 2007
    The paper is devoted to the investigation of chemical stability of lipids used as excipients in the production of Solid Lipid Nanoparticles (SLN). Different lipids and amounts of surfactants were considered...
  11. ncbi Barriers to nonviral gene delivery
    Christopher M Wiethoff
    Department of Pharmaceutical Chemistry, The University of Kansas, 2095 Constant Avenue, Lawrence, Kansas 66047, USA
    J Pharm Sci 92:203-17. 2003
    ..In this review, we outline in greater detail the various processes involved in each step and describe various formulation variables that have been explored to overcome these delivery barriers to nonviral gene delivery...
  12. ncbi 2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD): a toxicology review
    Sarah Gould
    Safety Assessment, AstraZeneca UK Limited, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, United Kingdom
    Food Chem Toxicol 43:1451-9. 2005
    ..HP-beta-CD has been shown to be well tolerated in humans, with the main adverse event being diarrhoea and there have been no adverse events on kidney function, documented to date...
  13. ncbi Kinetic analysis of the toxicity of pharmaceutical excipients Cremophor EL and RH40 on endothelial and epithelial cells
    Lorand Kiss
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Centre of the Hungarian Academy of Sciences, Szeged H 6726, Hungary
    J Pharm Sci 102:1173-81. 2013
    Cremophor EL and RH40 are widely used excipients in oral and intravenous drug formulations such as Taxol infusion to improve drug dissolution and absorption...
  14. ncbi Selection and characterization of suitable lipid excipients for use in the manufacture of didanosine-loaded solid lipid nanoparticles and nanostructured lipid carriers
    Kasongo Wa Kasongo
    Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Freie Universitat Berlin, 12169 Berlin, Germany
    J Pharm Sci 100:5185-96. 2011
    ..Precirol® ATO 5 and a mixture of Precirol® ATO 5 and Transcutol® HP may be used to manufacture DDI-loaded SLN and NLC, respectively...
  15. ncbi Use of a screening method to determine excipients which optimize the extent and stability of supersaturated drug solutions and application of this system to solid formulation design
    Roger Vandecruys
    Pharmaceutical Development, Johnson and Johnson Pharmaceutical Research and Development, Beerse, Belgium
    Int J Pharm 342:168-75. 2007
    Assessing the effect of excipients on the ability to attain and maintain supersaturation of drug-based solution may provide useful information for the design of solid formulations...
  16. ncbi Excipients enhance intestinal absorption of ganciclovir by P-gp inhibition: assessed in vitro by everted gut sac and in situ by improved intestinal perfusion
    Ming Li
    Huazhong University of Science and Technology, Wuhan, Hubei 430030, People s Republic of China
    Int J Pharm 403:37-45. 2011
    In rats we examined the effects of some common excipients on the intestinal absorption of ganciclovir (GCV), a BCS-III drug and substrate of P-gp, by assessing its in vitro transfer from mucosa to serosa and in situ transepithelial ..
  17. ncbi Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate, in rats
    Yulian Lin
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Kyoto, Japan
    Biol Pharm Bull 30:1301-7. 2007
    Effects of Labrasol and other pharmaceutical excipients on the intestinal transport and absorption of rhodamine123, a P-glycoprotein substrate (P-gp) were examined...
  18. ncbi Stable isotope-labeled excipients for drug product identification and counterfeit detection
    Linda A Felton
    Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, USA
    Drug Dev Ind Pharm 37:88-92. 2011
    ..This study examined the use of stable isotope-labeled excipients in solid dosage forms as a method to identify drug products and to detect counterfeits.
  19. ncbi Interactions of formulation excipients with proteins in solution and in the dried state
    Satoshi Ohtake
    Aridis Pharmaceuticals, 5941 Optical Court, San Jose, CA 95138, USA
    Adv Drug Deliv Rev 63:1053-73. 2011
    A variety of excipients are used to stabilize proteins, suppress protein aggregation, reduce surface adsorption, or to simply provide physiological osmolality...
  20. ncbi Tracking of the physical ageing of amorphous pharmaceutical polymeric excipients by positron annihilation spectroscopy
    Romána Zelkó
    University Pharmacy, Institute of Pharmacy Administration, Semmelweis University, Hogyes E Street 7 9, H 1092 Budapest, Hungary
    J Pharm Biomed Anal 40:249-54. 2006
    ..Positrons react to the structural changes of amorphous polymers very sensitively, so the method can be recommended as useful means for stability tests during the development phase of dosage forms containing such excipients.
  21. ncbi Exposure to the pharmaceutical excipients benzyl alcohol and propylene glycol among critically ill neonates
    Nadine Shehab
    Department of Clinical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
    Pediatr Crit Care Med 10:256-9. 2009
    To document neonatal exposures to the potentially harmful pharmaceutical excipients benzyl alcohol (BA) and propylene glycol (PG) present in parenteral medications routinely administered in the intensive care unit.
  22. ncbi An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances
    Matthew D Jones
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Eur J Pharm Biopharm 69:496-507. 2008
    ..It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance...
  23. ncbi The cohesive-adhesive balances in dry powder inhaler formulations II: influence on fine particle delivery characteristics
    Philippe Begat
    Pharmaceutical Technology Research Group, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    Pharm Res 21:1826-33. 2004
    ..To investigate the influence of the cohesive-adhesive balances on dry powder formulation aerosolization and delivery characteristics...
  24. ncbi Manufacturing techniques and excipients used during the design of biodegradable polymer-based microspheres containing therapeutic peptide/protein for parenteral controlled drug delivery
    S Tamilvanan
    Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Antwerp, Belgium
    PDA J Pharm Sci Technol 62:125-54. 2008
    ..The solubilization, stabilization, and preservation enhancing excipients that are used in peptide/protein-loaded microspheres are briefly overviewed.
  25. ncbi Carbon nanotubes as functional excipients for nanomedicines: II. Drug delivery and biocompatibility issues
    Marianna Foldvari
    Faculty of Science, School of Pharmacy, University of Waterloo, Waterloo, Ontario, Canada
    Nanomedicine 4:183-200. 2008
    ..potential novel application in nanomedicine as biocompatible and supportive substrates, and as pharmaceutical excipients for creating versatile drug delivery systems...
  26. ncbi Carbon nanotubes as functional excipients for nanomedicines: I. Pharmaceutical properties
    Marianna Foldvari
    School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, Ontario, Canada
    Nanomedicine 4:173-82. 2008
    ..Pharmaceutical excipients have been regarded as inert or nonactive components of dosage forms, but they are essential and necessary ..
  27. ncbi Mechanism of protein stabilization by sugars during freeze-drying and storage: native structure preservation, specific interaction, and/or immobilization in a glassy matrix?
    Liuquan Lucy Chang
    Department of Pharmaceutical Science, School of Pharmacy, University of Connecticut, Storrs, CN 06269, USA
    J Pharm Sci 94:1427-44. 2005
    ..However, while a specific interaction between stabilizer and protein might be responsible for the preservation of native structure, the evidence supporting this position is not compelling...
  28. ncbi Formulation strategy and use of excipients in pulmonary drug delivery
    Gabrielle Pilcer
    Laboratory of Pharmaceutics and Biopharmaceutics, Universite Libre de Bruxelles, Belgium
    Int J Pharm 392:1-19. 2010
    ..Several excipients such as sugars, lipids, amino acids, surfactants, polymers and absorption enhancers have been tested for their ..
  29. ncbi Self-nanoemulsifying drug delivery systems of tamoxifen citrate: design and optimization
    Yosra S R Elnaggar
    Department of Pharmaceutics, Faculty of Pharmacy, University of Alexandria, Alexandria, Egypt yosra
    Int J Pharm 380:133-41. 2009
    ..Realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant, our results proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate...
  30. ncbi What determines drug solubility in lipid vehicles: is it predictable?
    Sagar S Rane
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA
    Adv Drug Deliv Rev 60:638-56. 2008
    ..The ability to predict lipid solubility is an important step in being able to identify the right excipients to solubilize and formulate drugs in lipid formulations...
  31. ncbi In vitro-in vivo correlations of self-emulsifying drug delivery systems combining the dynamic lipolysis model and neuro-fuzzy networks
    Dimitrios G Fatouros
    Department of Pharmaceutics and Analytical Chemistry, University of Copenhagen, Copenhagen, Denmark
    Eur J Pharm Biopharm 69:887-98. 2008
    ..These preliminary results suggest that the dynamic lipolysis model combined with the AFM-IVIVC can be a useful tool in the prediction of the in vivo behavior of lipid-based formulations...
  32. ncbi Selection of excipients for melt extrusion with two poorly water-soluble drugs by solubility parameter calculation and thermal analysis
    A Forster
    School of Pharmacy, University of Otago, Dunedin, New Zealand
    Int J Pharm 226:147-61. 2001
    ..Two poorly water-soluble drugs, indomethacin and lacidipine, were selected along with 11 excipients (polymeric and non-polymeric)...
  33. ncbi Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS
    Thao Do Thi
    Laboratory for Pharmacotechnology and Biopharmacy, Catholic University of Leuven, Belgium
    Eur J Pharm Sci 38:479-88. 2009
    ..The best performing excipients were selected for SMEDDS formulation...
  34. ncbi In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self emulsifying excipients Labrasol and Gelucire 44/14
    Sylvie Fernandez
    Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse, CNRS UPR 9025, 31 Chemin Joseph Aiguier, 13402, Marseille Cedex 20, France
    Pharm Res 26:1901-10. 2009
    ..Labrasol and Gelucire 44/14 are defined admixtures of acylglycerols and PEG esters which are substrates for digestive lipases...
  35. ncbi Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide
    A David Woolfson
    School of Pharmacy, Queen s University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK
    Int J Pharm 325:82-9. 2006
    ..In this study we report on the incorporation of various pharmaceutical excipients into TMC 120 silicone, reservoir-type intravaginal rings (IVRs) in order to modify the controlled release ..
  36. ncbi The effects of excipients on transporter mediated absorption
    Jonathan Goole
    Department of Industrial and Physical Pharmacy, College of Pharmacy, Nursing and Health Sciences, Purdue University, West Lafayette, IN, USA
    Int J Pharm 393:17-31. 2010
    Traditionally most pharmaceutical excipients used for peroral dosage forms have been considered to be inert, although they have been known to play an important role in governing the release of the active pharmaceutical ingredient (API) ..
  37. ncbi Freeze drying of human serum albumin (HSA) nanoparticles with different excipients
    Marion G Anhorn
    Institute of Pharmaceutical Technology, Biocenter of Johann Wolfgang Goethe University, Frankfurt, Germany
    Int J Pharm 363:162-9. 2008
    ..Aim of this study was to systematically evaluate excipients for the freeze drying and long-term stability of albumin-based nanoparticles...
  38. ncbi CDs as solubilizers: effects of excipients and competing drugs
    Phatsawee Jansook
    Faculty of Pharmaceutical Sciences, University of Iceland, Hofsvallagata 53, IS 107 Reykjavik, Iceland
    Int J Pharm 379:32-40. 2009
    In recent years cyclodextrins (CDs) have been acknowledged by the pharmaceutical industry as very useful enabling excipients for solubilization and stabilization of drugs in aqueous formulations...
  39. ncbi In vitro investigation on the impact of the surface-active excipients Cremophor EL, Tween 80 and Solutol HS 15 on the metabolism of midazolam
    Roberto C Bravo González
    Discovery DMPK, F Hoffmann La Roche Ltd, Grenzacher Strasse 124, Basel, Switzerland
    Biopharm Drug Dispos 25:37-49. 2004
    ....
  40. ncbi The STEP (Safety and Toxicity of Excipients for Paediatrics) database: part 2 - the pilot version
    Smita Salunke
    Department of Pharmaceutics and Centre for Paediatric Pharmacy Research, UCL School of Pharmacy, London, United Kingdom Electronic address
    Int J Pharm 457:310-22. 2013
    The screening and careful selection of excipients is a critical step in paediatric formulation development as certain excipients acceptable in adult formulations, may not be appropriate for paediatric use...
  41. ncbi Pharmaceutical excipients influence the function of human uptake transporting proteins
    Anett Engel
    Department of Clinical Pharmacology, Ernst Moritz Arndt University Greifswald, 17487 Greifswald, Germany
    Mol Pharm 9:2577-81. 2012
    Although pharmaceutical excipients are supposed to be pharmacologically inactive, solubilizing agents like Cremophor EL have been shown to interact with cytochrome P450 (CYP)-dependent drug metabolism as well as efflux transporters such ..
  42. ncbi Vascular effects of paclitaxel following drug-eluting balloon angioplasty in a porcine coronary model: the importance of excipients
    Peter W Radke
    Medical Clinic II, Cardiology, Angiology and Intensive Care Medicine, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    EuroIntervention 7:730-7. 2011
    ..This study evaluated potential vascular effects of paclitaxel-coated angioplasty balloons using different excipients in the absence of additional stents.
  43. ncbi Quantitative solubility relationships and the effect of water uptake in triglyceride/monoglyceride microemulsions
    Sagar S Rane
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, A323A, ASTeCC Building, Lexington, KY 40536, USA
    Pharm Res 25:1158-74. 2008
    ..This paper aims to elucidate quantitative relationships between small molecule solubility/water-uptake in triglyceride/monoglyceride lipid formulations, the chemical structure of the solute, and the solvent composition...
  44. ncbi Screening method to identify preclinical liquid and semi-solid formulations for low solubility compounds: miniaturization and automation of solvent casting and dissolution testing
    Paul Mansky
    ALZA Corporation, 1010 Joaquin Road, Mountain View, California 94043, USA
    J Pharm Sci 96:1548-63. 2007
    ..the method, two compounds (aqueous solubility </=1 microg/mL) were combined with eight solubilizing excipients, at four drug-loading levels (25, 50, 75, and 100 mg/g) and three incubation times (0.5, 2, and 24 h)...
  45. ncbi Development of level A, B and C in vitro-in vivo correlations for modified-release levosimendan capsules
    H Kortejärvi
    Orion Pharma, PO Box 65, FIN 02101, Espoo, Finland
    Int J Pharm 241:87-95. 2002
    ..Formulations F, G, H and I differed in the amounts of the delaying excipients alginic acid and HPMC...
  46. ncbi A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitro
    Erin D Hugger
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 91:1991-2002. 2002
    ..Previous studies in our laboratory have shown that excipients such as poly(ethylene)glycol (PEG)-300, Cremophor EL, and Tween 80 inhibit P-gp activity in Caco-2 cell ..
  47. ncbi Cyclodextrins as functional excipients: methods to enhance complexation efficiency
    Thorsteinn Loftsson
    Faculty of Pharmaceutical Sciences, University of Iceland, IS 107 Reykjavik, Iceland
    J Pharm Sci 101:3019-32. 2012
    Cyclodextrins have gained currency as useful solubilizing excipients with an ever increasing list of beneficial properties and functionalities...
  48. ncbi Predicting the solubility of the anti-cancer agent docetaxel in small molecule excipients using computational methods
    Loan Huynh
    Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada
    Pharm Res 25:147-57. 2008
    To develop an in silico model that provides an accurate prediction of the relative solubility of the lipophilic anticancer agent docetaxel in various excipients.
  49. ncbi Use of high resolution mass spectrometry for analysis of polymeric excipients in drug delivery formulations
    Pilar Perez Hurtado
    Department of Chemistry, University of Warwick, Coventry, United Kingdom
    Anal Chem 84:8579-86. 2012
    Two polymeric excipients, typically used in enabling drug delivery approaches, are Gelucire 44/14 (a product of Gattefosse s...
  50. ncbi Hydrogels in calcium phosphate moldable and injectable bone substitutes: Sticky excipients or advanced 3-D carriers?
    M D'Este
    AO Research Institute Davos, Clavadelerstrasse 8, Davos, Switzerland
    Acta Biomater 9:5421-30. 2013
    ..The aim of this review is to collect some recent progress in this field, with an emphasis on design aspects and possible future directions...
  51. ncbi A decision-support tool for the formulation of orally active, poorly soluble compounds
    Sébastien Branchu
    Pharmaceutical and Analytical Research and Development, AstraZeneca R and D Charnwood, Bakewell Road, Loughborough, Leicestershire LE11 5RH, UK
    Eur J Pharm Sci 32:128-39. 2007
    ..The tool was tested and exhibited significant and consistent predictive ability across testing conditions. This type of tool has the potential to improve the efficiency and predictability of the formulation development process...
  52. ncbi Topical delivery of aceclofenac as nanoemulsion comprising excipients having optimum emulsification capabilities: preparation, characterization and in vivo evaluation
    Sandipan Dasgupta
    Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India
    Expert Opin Drug Deliv 10:411-20. 2013
    The aim of the present study was to investigate the potential of a nanoemulsion for topical delivery of aceclofenac using different excipients having optimum emulsifying ability rather than their solubilizing capacity.
  53. ncbi Compressed orally disintegrating tablets: excipients evolution and formulation strategies
    Ali Al-Khattawi
    Aston University, Aston Pharmacy School, Aston Triangle, Birmingham B4 7ET, UK
    Expert Opin Drug Deliv 10:651-63. 2013
    ..Of the plethora of available technologies, compression of excipients offers a cost-effective and translatable methodology for the manufacture of ODTs.
  54. ncbi Parallel screening approach to identify solubility-enhancing formulations for improved bioavailability of a poorly water-soluble compound using milligram quantities of material
    Wei Guo Dai
    ALZA Corporation, 1900 Charleston Road, Mountain View, CA 94039, USA
    Int J Pharm 336:1-11. 2007
    ..The lead compound and a panel of excipients were dissolved in n-propanol and dispensed into the wells of a 96-well microtiter plate by a TECAN robot...
  55. pmc Effects of commonly used excipients on the expression of CYP3A4 in colon and liver cells
    Leslie Tompkins
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 Penn Street, Baltimore, Maryland 21201, USA
    Pharm Res 27:1703-12. 2010
    The objective of this investigation was to assess whether common pharmaceutical excipients regulate the expression of drug-metabolizing enzymes in human colon and liver cells.
  56. ncbi The safety of pharmaceutical excipients
    Giorgio Pifferi
    Institute of Pharmaceutical and Toxicological Chemistry, V le Abruzzi 42, Milan, Italy
    Farmaco 58:541-50. 2003
    The most important part of a medicine as far as its weight is concerned, is constituted by its excipients, which have the important functions of guaranteeing the dosage, stability and bioavailability of the active principle...
  57. ncbi High-throughput study of phenytoin solid dispersions: formulation using an automated solvent casting method, dissolution testing, and scaling-up
    Valery Barillaro
    Laboratory for Pharmacotechnology and Biopharmacy, K U Leuven, Gasthuisberg O and N2, Herestraat 49, 3000 Leuven, Belgium
    J Comb Chem 10:637-43. 2008
    ..Solid dispersions with 12 excipients (7 polymers and 5 surfactants) were prepared and tested...
  58. ncbi Physicochemical characterization of artemether solid dispersions with hydrophilic carriers by freeze dried and melt methods
    Muhammad Tayyab Ansari
    Department of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan
    Arch Pharm Res 33:901-10. 2010
    ..drug, were prepared using polyvinylpyrrolidone (PVPK25, MW 25000) and polyethyleneglycol (PEG4000, MW 4000) as excipients. These dispersions were studied by physical mixture, freeze-drying, and melting methods...
  59. ncbi Investigation into the influence of polymeric stabilizing excipients on inter-particulate forces in pressurised metered dose inhalers
    D Traini
    Pharmaceutical Surface Science Research Group, Department of Pharmacy, University of Bath, Bath BA2 7AY, United Kingdom
    Int J Pharm 320:58-63. 2006
    ..In this context, the use of the colloid probe AFM technique has provided a quantitative insight into the interactions of these complex systems and may be an invaluable asset during the early phase of formulation product development...
  60. ncbi Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer
    J Shaikh
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar 160062, Punjab, India
    Eur J Pharm Sci 37:223-30. 2009
    ..Together the results clearly indicate the promise of nanoparticles for oral delivery of poorly bioavailable molecules like curcumin...
  61. ncbi Multifunctional coprocessed excipients for improved tabletting performance
    Sumit Saha
    National Institute of Pharmaceutical Education and Research NIPER Ahmedabad, C o B V Patel Pharmaceutical Education and Research Development Centre, S G Highway, Thaltej, Ahmedabad 380054, India
    Expert Opin Drug Deliv 6:197-208. 2009
    With the advancement of tablet manufacturing process, the demand of excipients with improved functionalities, mainly in terms of flow and compression properties, has increased...
  62. ncbi Dissolution rate enhancement of parabens in PEG solid dispersions and its influence on the release from hydrophilic matrix tablets
    Farhad Tajarobi
    AstraZeneca R and D, SE 431 83 Molndal, Sweden
    J Pharm Sci 100:275-83. 2011
    ..This was proposed to be an effect of differences in the dissolution and crystallization kinetics of the parabens...
  63. ncbi The influence of excipients on drug release from hydroxypropyl methylcellulose matrices
    Marina Levina
    Colorcon Limited, Flagship House, Victory Way, Crossways, Dartford, Kent DA2 6QD, UK
    J Pharm Sci 93:2746-54. 2004
    The influence of commonly used excipients, spray-dried lactose (SDL), microcrystalline cellulose (MCC), and partially pregelatinized maize starch (Starch 1500) on drug release from hydroxypropyl methylcellulose (HPMC, hypromellose) matrix ..
  64. pmc In vitro and in vivo studies on chitosan beads of losartan Duolite AP143 complex, optimized by using statistical experimental design
    Ashwini Madgulkar
    AISSMS College of Pharmacy, Shivajinagar, Pune 411001, India
    AAPS PharmSciTech 10:743-51. 2009
    ..The pharmacodynamic study demonstrates steady blood pressure control for optimized formulation as compared to fluctuated blood pressure for the marketed formulation...
  65. ncbi Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies
    Douglas D Banks
    Department of Drug Product Development, Amgen Inc, Seattle, Washington 98119 3105, USA
    J Pharm Sci 101:2720-32. 2012
    ..strategies, based on different aggregation models, were compared for their ability to quickly predict which excipients (cosolutes) would minimize the aggregation rate of an immunoglobulin G1 monoclonal antibody (mAb-1) stored for ..
  66. ncbi Behavior of uptake of moisture by drugs and excipients under accelerated conditions of temperature and humidity in the absence and the presence of light. 1. Pure anti-tuberculosis drugs and their combinations
    Saranjit Singh
    Department of Pharmaceutical Analysis, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, 160 062, S A S Nagar, India
    Int J Pharm 245:37-44. 2002
    ..The most interesting finding was an overall acceleration of weight gain in the presence of light as compared with dark conditions, which is a hitherto unknown phenomenon...
  67. ncbi Novel buccal adhesive system for anti-hypertensive agent nimodipine
    Nisreen Hassan
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi, India
    Pharm Dev Technol 15:124-30. 2010
    ..It can be considered that NBAS is a superior, novel system that overcomes the drawback associated with the conventional buccal adhesive tablet...
  68. ncbi Metabolic inhibition and kinetics of raloxifene by pharmaceutical excipients in human liver microsomes
    Ae Ra Kim
    National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University, Chuncheon, Republic of Korea
    Int J Pharm 368:37-44. 2009
    ..undertaken to establish the in vitro metabolic conditions and then evaluate the effect of pharmaceutical excipients (PEs) on drug metabolism in uridine diphosphoglucuronic acid-supplemented human liver microsomes...
  69. ncbi Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies
    Richard S Kaye
    Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Pharm Sci 98:4055-68. 2009
    ....
  70. ncbi Formulation and in vitro evaluation of ofloxacin-ethocel controlled release matrix tablets prepared by wet granulation method: influence of co-excipients on drug release rates
    Shefaatullah Shah
    Drug Delivery Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan, Pakistan
    Pak J Pharm Sci 24:255-61. 2011
    ..F1 dissimilarity factor and f2 similarity factor were applied to the formulations for the checking of dissimilarities and similarities between the tested formulations and reference standard...
  71. ncbi Release of indomethacin from ultrasound dry granules containing lactose-based excipients
    Cristina Cavallari
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Italy
    J Control Release 102:39-47. 2005
    Physical mixtures were prepared containing indomethacin and beta-lactose and alpha-lactose-based excipients (Ludipress and Cellactose)...
  72. ncbi Effects of excipients on the hydrogen peroxide-induced oxidation of methionine residues in granulocyte colony-stimulating factor
    Jin Yin
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Pharm Res 22:141-7. 2005
    The objective of this study was to elucidate the different mechanisms of action of different excipients on the oxidation of Met1, Met122, Met127, and Met138 in granulocyte colony-stimulating factor (G-CSF) by using hydrogen peroxide as ..
  73. ncbi Severe skin reaction due to excipients of an oral iron treatment
    A Rogkakou
    Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, Genoa, Italy
    Allergy 62:334-5. 2007
  74. ncbi Supersaturating drug delivery systems: effect of hydrophilic cyclodextrins and other excipients on the formation and stabilization of supersaturated drug solutions
    M E Brewster
    Pharmaceutical Sciences, Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, Beerse, Belgium
    Pharmazie 63:217-20. 2008
    ..To this end, a series of excipients was tested in a co-solvent/solvent quench method to assess their ability to attain and maintain supersaturation ..
  75. ncbi Evaluation of the moisture sorption behaviour of several excipients by BET, GAB and microcalorimetric approaches
    Robert Roskar
    Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000 Ljubljana, Slovenia
    Chem Pharm Bull (Tokyo) 53:662-5. 2005
    ..obtained data, both methods were applied in the present work to evaluate the sorption characteristics of several excipients. Microcalorimetric analysis was also performed in order to evaluate the interaction between water and the ..
  76. ncbi Experimental observations of dry powder inhaler dose fluidisation
    Rob Tuley
    Mechanical Engineering Department, Imperial College London, UK
    Int J Pharm 358:238-47. 2008
    ..Further analysis of the four powder types by an annular shear cell showed that the fluidisation mechanism cannot be predicted using bulk powder properties...
  77. ncbi Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation
    Shyamal Das
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Victoria 3052, Australia
    J Pharm Sci 98:1015-27. 2009
    ....
  78. ncbi Thiolated chitosans: useful excipients for oral drug delivery
    Martin Werle
    ThioMatrix GmbH, Research Center Innsbruck, Mitterweg 24, 6020 Innsbruck, Austria
    J Pharm Pharmacol 60:273-81. 2008
    ....
  79. ncbi Solid state interaction of raloxifene HCl with different hydrophilic carriers during co-grinding and its effect on dissolution rate
    Anuj Garg
    Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India
    Drug Dev Ind Pharm 35:455-70. 2009
    ..In vitro dissolution data can be described by Hixson-Crowell model, indicating the drug release mechanism predominated by erosion...
  80. ncbi An investigation into the usefulness of generalized regression neural network analysis in the development of level A in vitro-in vivo correlation
    Jelena Parojcic
    Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
    Eur J Pharm Sci 30:264-72. 2007
    ....
  81. ncbi Pluronic-g-poly(acrylic acid) copolymers as novel excipients for site specific, sustained release tablets
    Rafael Barreiro-Iglesias
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Eur J Pharm Sci 26:374-85. 2005
    ..copolymers comprising Pluronic (PEO-PPO-PEO) surfactants covalently conjugated with poly(acrylic acid) (PAA) as excipients for sustained-release tablets was explored...
  82. ncbi Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity
    Shyamal Das
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Victoria 3052, Australia
    Eur J Pharm Sci 37:442-50. 2009
    ..This study investigated changes in agglomeration and the mechanism of dispersibility decrease of salmeterol xinafoate (SX) from SX-lactose mixtures for inhalation after storage at 75% RH for 3 months...
  83. ncbi Nebulization of ultradeformable liposomes: the influence of aerosolization mechanism and formulation excipients
    Abdelbary M A Elhissi
    Institute of Nanotechnology and Bioengineering, University of Central Lancashire, Preston PR1 2HE, United Kingdom
    Int J Pharm 436:519-26. 2012
    ....
  84. ncbi Cyclodextrins: more than pharmaceutical excipients
    F J Otero-Espinar
    Departamento de Farmacia y Tecnologia Farmaceutica, Facultad de Farmacia, Campus Universitario sur s n 15782 Santiago de Compostela, Spain
    Mini Rev Med Chem 10:715-25. 2010
    Cyclodextrins are pharmaceutical excipients used to enhance the solubility, stability, safety and bioavailability of drugs...
  85. ncbi Transformation of pharmaceutical compounds upon milling and comilling: the role of T(g)
    M Descamps
    Laboratoire de Dynamique et Structure des Materiaux Moleculaires, UMR, CNRS 8024, University of Lille1, Bat P5 59655 Villeneuve d Ascq Cedex, France
    J Pharm Sci 96:1398-407. 2007
    ..Other results are also presented, which demonstrate the possibility for milling to form low temperature solid-state alloys that offer new promising ways to stabilize amorphous molecular solids...
  86. ncbi Novel multifunctional pharmaceutical excipients derived from microcrystalline cellulose-starch microparticulate composites prepared by compatibilized reactive polymer blending
    Philip F Builders
    Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria
    Int J Pharm 388:159-67. 2010
    The choice of excipients remains a critical factor in pharmaceutical formulations...
  87. ncbi Toxicity of excipients--a Food and Drug Administration perspective
    Robert E Osterberg
    Center for Drug Evaluation and Research, US Food and Drug Administration, Rockville, Maryland 20850, USA
    Int J Toxicol 22:377-80. 2003
    b>Excipients are essential components of drug products. They are also potential toxicants...
  88. ncbi The use of unallowed excipients
    Marshall Steinberg
    International Pharmaceutical Excipient Council, Arlington, Virginia, USA
    Int J Toxicol 22:373-5. 2003
    The laws governing the U.S. Food and Drug Administration (FDA) do not provide for the approval of stand-alone excipients. Current regulations do not permit the use of excipients, but allow their use...
  89. ncbi Fast assessment of the surface distribution of API and excipients in tablets using NIR-hyperspectral imaging
    Felicidad Franch-Lage
    Departament de Quimica, Unitat de Quimica Analitica, Universitat Autonoma de Barcelona, Spain
    Int J Pharm 411:27-35. 2011
    ..The correct distribution not only of active pharmaceutical ingredient (API) but also of the rest of excipients is essential to assure the correct behavior of the tablet when ingested...
  90. ncbi Investigating the in vitro drug release kinetics from controlled release diclofenac potassium-ethocel matrix tablets and the influence of co-excipients on drug release patterns
    Shefaat Ullah Shah
    Drug Delivery Research Center, Department of Pharmaceutics, Faculty of Pharmacy, Gomal University, Dera Ismail Khan KPK, Pakistan
    Pak J Pharm Sci 24:183-92. 2011
    ....
  91. ncbi Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy
    Holger Grohganz
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen, Denmark
    J Pharm Biomed Anal 49:901-7. 2009
    ..The ratio of these common excipients influences a critical quality attribute of the system, namely the overall amount of water, due to the different ..
  92. ncbi The effects of pharmaceutical excipients on drug disposition
    Talia R Buggins
    Welsh School of Pharmacy, Cardiff University, Cardiff, UK
    Adv Drug Deliv Rev 59:1482-503. 2007
    Many new chemical entities are poorly soluble, requiring the use of co-solvents or excipients to produce suitable intravenous formulations for early pre-clinical development studies...
  93. ncbi Active and passive immunity, vaccine types, excipients and licensing
    David Baxter
    Epidemiology and Health Sciences, Stopford Building, Manchester University Medical School, Oxford Road, Manchester, UK
    Occup Med (Lond) 57:552-6. 2007
    ....
  94. ncbi Investigation of nanocapsules stabilization by amorphous excipients during freeze-drying and storage
    Wassim Abdelwahed
    Universite Claude Bernard Lyon 1, Villeurbanne Cedex, France
    Eur J Pharm Biopharm 63:87-94. 2006
    ..Such adsorption must be avoided in the case of freeze-drying of immuno-nanoparticles to preserve the native structure of proteins attached to their surface...
  95. ncbi Comparison of the effect of two excipients (karite nut butter and vaseline) on the efficacy of Cocos nucifera, Elaeis guineensis and Carapa procera oil-based repellents formulations against mosquitoes biting in Ivory Coast
    Y L Konan
    Pierre Richet Institute, 01 BP 1500 Bouaké 01, Ivory Coast
    Parasite 10:181-4. 2003
    ..and Carapa procera (gobi) were effective against mosquitoes, it became necessary to study the impact of the two excipients used in their manufacture, on the effectiveness of the repellents...
  96. ncbi Predicting the formation and stability of amorphous small molecule binary mixtures from computationally determined Flory-Huggins interaction parameter and phase diagram
    Katja Pajula
    School of Pharmacy and Department of Physics and Mathematics, University of Eastern Finland, P O Box 1627, FI 70211 Kuopio, Finland
    Mol Pharm 7:795-804. 2010
    ..The method described can enable fast screening of the potential stabilizers needed to produce a stable amorphous binary mixture...
  97. ncbi Recent advances in pharmacokinetics of polymeric excipients used in nanosized anti-cancer drugs
    Nguyen Van Cuong
    Department of Biomedical Engineering and R and D Center for Biomedical Microdevice Technology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China
    Curr Drug Metab 10:842-50. 2009
    ..Their derivatives are also analyzed. Additionally, some diseases with very good responsiveness are aslo reported...
  98. ncbi Formulation and characterization of ternary solid dispersions made up of Itraconazole and two excipients, TPGS 1000 and PVPVA 64, that were selected based on a supersaturation screening study
    Sandrien Janssens
    Laboratorium voor Farmacotechnologie en Biofarmacie, Catholic University of Leuven, Leuven, Belgium
    Eur J Pharm Biopharm 69:158-66. 2008
    ..The precipitation after 1h, however, is probably due to the combination of the surfactant properties of TPGS and the small crystalline Itraconazole fraction...
  99. ncbi Effect of pharmaceutical excipients on aqueous stability of rabeprazole sodium
    Shan Ren
    College of Pharmacy, Kangwon National University, Chuncheon 200 701, South Korea
    Int J Pharm 350:197-204. 2008
    ..8) containing various 'Generally Recognized As Safe (GRAS)'-listed excipients, including Brij 58, Poloxamer 188, Cremophor RH40, Gelucire 44/14 and PEG 6000...
  100. ncbi Scanning probe microscopy in the field of drug delivery
    Ya Tsz A Turner
    Laboratory of Biophysics and Surface Analysis, School of Pharmacy, The University of Nottingham, NG7 2RD, UK
    Adv Drug Deliv Rev 59:1453-73. 2007
    ..In formulation, the use of SPMs in different drug delivery systems is discussed in light of different host entry routes...
  101. ncbi Novel methods for the assessment of miscibility of amorphous drug-polymer dispersions
    Igor Ivanisevic
    J Pharm Sci 98:3373-86. 2009
    ..It is proposed that the NN coordination number is related to physical stability...

Research Grants62

  1. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..analytical measures of first pure chiral pharmaceutical samples, including protein pharmaceuticals, and then excipients of various kinds...
  2. Development of liposomal fenretinide and safingol
    William Ernst; Fiscal Year: 2004
    ..Attempts to solubilize fenretinide with standard excipients (e.g. Cremophor-EL) have lead to toxic side effects in rodents and dogs...
  3. Development of Montelukast Delivery System for Childhood Asthma
    Je Phil Ryoo; Fiscal Year: 2013
    ..the drug together with Bio-FX oral cavity absorption enhancers, polymer carriers, taste-masking agents and other excipients, and display many advantages including fast onset and improved bioavailability, as well as less GI tract and ..
  4. Preclinical Development of a Novel and Effective Treatment for Cough
    Blake M Paterson; Fiscal Year: 2011
    ..The research strategy utilizes the combined expertise and resources of CBDM and JHMI. For Aim 1, we will screen excipients listed in the FDA Inactive Ingredient List for their ability to accelerate MMT kinetics using in vitro ..
  5. Optimization of Protein Therapeutics Formulations
    Lawrence J Delucas; Fiscal Year: 2012
    ..protein by measuring the second virial coefficient (B-value) for the protein in solutions containing different excipients. In addition to developing the 3rd generation system, a second area with significant commercial potential will ..
  6. Oral paclitaxel solubilized and bioenhanced by food compound for cancer therapy
    Zhijun Liu; Fiscal Year: 2013
    ..offers great advantages to cancer patients, including the minimization or elimination of infusion-procedure- and excipients-induced side effects (e.g., nausea, hypersensitivity reactions) and significant cost savings...
  7. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..In Specific Aim 1, interaction of drugs with excipients such as sweeteners (e.g., saccharin, sucralose, sucrose) and diluents/binder (e.g...
  8. Effective Delivery of Pharmaceutical Aerosols during Non-Invasive Ventilation
    P Worth Longest; Fiscal Year: 2012
    ..aerosol is delivered with a saturated or supersaturated warm airstream and/or with the inclusion of hygroscopic excipients in order to foster condensational growth, leading to increased aerosol size and pulmonary deposition...
  9. Development of stable and rapidly acting adjuvanted vaccines for biodefense
    ROBERT NEWTON BREY; Fiscal Year: 2013
    ..This will be accomplished by using a drying technology and excipients that prevent the aggregation of aluminum adjuvant particles during freeze-drying and subsequent storage, while ..
  10. Functionalized Micellar Nanocarriers for Targeted Cancer Therapy
    Chalet Tan; Fiscal Year: 2010
    ..of 17-AAG have been hampered owing to its severe hepatotoxicity as well as the large amount of toxic organic excipients used in the current intravenous formulations...
  11. Oral transmucosal drug delivery system for naltrexone
    HOCK SENG TAN; Fiscal Year: 2013
    ..The naltrexone ODF is a small, thin, and flexible film, containing naltrexone hydrochloride and other excipients. It is applied intra-orally and adheres to the oral mucosa to affect a rapid onset of action due to oral mucosal ..
  12. DRUG METABOLISM BY INTESTINAL FLAVIN MONOOXYGENASES
    ROSITA PROTEAU; Fiscal Year: 2001
    ..Recently, patents have been filed which incorporate flavonoids as excipients in pharmaceutical formulations with the intent to alter drug absorption characteristics within the intestine...
  13. TAS::75 0849::TAS PURIFICATION, REFORMULATION AND PHARMACOKINETICS OF NITROSYLCO
    Joseph Bauer; Fiscal Year: 2010
    ..A variety of excipients will be used to design test formulations for their ability to achieve an optimized PK profile and work ..
  14. A Thermostable Measles Vaccine
    Jeffrey K Griffiths; Fiscal Year: 2010
    ..In this re-application, we focus our efforts on the development of the measles vaccine itself using accepted excipients. In consultations with WHO and others, we have learned that if our approach is successful, it will be viewed as ..
  15. Drug-Dietary Flavonoid Intestinal Absorption Interaction
    ROSITA PROTEAU; Fiscal Year: 2002
    ..Furthermore, patents have been filed which incorporate flavonoids as excipients in pharmaceutical formations with the intent to alter drug absorption...
  16. High Capacity Nanocarriers for Cancer Chemotherapeutics
    Alexander V Kabanov; Fiscal Year: 2013
    ..The micelles will carry paclitaxel and docetaxel using drastically less amount of excipients relative to current formulations. Hence, excipient-associated toxicities will be decreased...
  17. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..salts, sugars, amino acids, and biomolecules that exist in nature - many of which have already been approved as excipients. The exciting feature of ILs is that, because they consist of chemically distinct ions, the hydrogen-bonding ..
  18. 2-D Diffusion Assay on Polymer Brush for POC Cardiac Infarction Diagnosis
    Ashutosh Chilkoti; Fiscal Year: 2013
    ..stable" spots of capture antibodies (Abc) and "soluble" spots of detection reagents that are printed with excipients so that they dissolve upon contact with blood...
  19. Asthma Treatment with a Novel Drug Aerosol Generator
    William Shen; Fiscal Year: 2004
    ..All current inhalation delivery systems contain significant amounts of excipients; excipients in pulmonary delivery may induce airway hypersensitivity...
  20. Development of concentrated and rapidly absorbed insulins for closed loop systems
    Roderike Pohl; Fiscal Year: 2013
    ..proposes to optimize multiple pH 7 aqueous formulations of concentrated recombinant human insulin together with excipients which in U-100 formulations have been shown to be ultra-rapid acting, to provide a minimum of 18 month stability ..
  21. Topical Salicylanilides to Treat Diabetic Foot Ulcer
    Joseph Dunn; Fiscal Year: 2002
    ..topical anti-inflammatory activity, and preliminary formulation studies to accessibility and compatibility with excipients and solubilizing agents...
  22. TOPICAL DRUG DELIVERY FOR GASTRIC H. PYLORI INFECTION
    Catherine Woods; Fiscal Year: 2000
    ..Two classes of formulations are to be evaluated: poloxamers containing different excipients and fluorocarbon-hydrocarbon diblocks containing medium chain triglycerides...
  23. Treatment of Migraine Attacks by Drug Aerosol Inhalation
    Joshua Rabinowitz; Fiscal Year: 2002
    ..by ALEXZA's novel aerosol generation approach, which can produce very small particle aerosols without using any excipients or entrainers. Our technique has already proven to be successful on several FDA drugs...
  24. Rapid Quality Control Technology for Biodefense Vaccines
    Boris Zaslavsky; Fiscal Year: 2002
    ..Issues such as the effects of various excipients, pH, salts, and lyophilization would be examined...
  25. Inhaled dopamine agonist for late stage Parkinsonism
    Joshua Rabinowitz; Fiscal Year: 2003
    ..aerosol generation method that produces very small particles for efficient deep lung inhalation without any excipients or entrainers...
  26. Mucoadhesive buprenorphine for opioid addiction therapy
    Sudip Das; Fiscal Year: 2003
    ..of this proposal include the formulation of dosage forms of buprenorphine with mucoadhesive polymers and other excipients using a statistical design, followed by in vitro screening of physicochemical characteristics, mucoadhesive ..
  27. LYOPHILIZATION OF NONVIRAL GENE DELIVERY SYSTEMS
    THOMAS ANCHORDOQUY; Fiscal Year: 2002
    ..The work described in this proposal will test whether the mechanisms employed by excipients to stabilize other biopharmaceuticals in the dried state are applicable to macromolecular complexes used in gene ..
  28. PRECLINICAL DEVELOP. OF A NEW DRUG FOR PCP AND MALARIA
    Mahmoud Elsohly; Fiscal Year: 2001
    ..of the GMP drug substance NPC1161B, assess compatibility of the drug with commonly used capsule formation excipients; 2) Evaluate the stereoisomers of NPC1161 (NCP1161A and NCP1161B) in primate models for relative antimalarial ..
  29. Quality by Design of orally inhaled drug products: Chemistry, Manufacturing and C
    Robert Price; Fiscal Year: 2011
    ..and critical quality attributes (CQAs) of raw materials (both the active pharmaceutical ingredient and excipients) is critical to the successful development of a safe and efficacious DPI product...
  30. Novel Inhalation System for Delivering Vapor-State Drugs
    Daniel Mufson; Fiscal Year: 2002
    ..The inhaler is the first to deliver vapor-state drug without excipients. The inhaled, reproducible dose will be absorbed from the lung rapidly with high bioavailability, providing ..
  31. BIOERODIBLE NARCOTIC ANTAGONIST DELIVERY DEVICE
    Jorge Heller; Fiscal Year: 1990
    ..poly(ortho esters) are acid sensitive rate of hydrolysis can be controlled by means of incorporated acidic excipients or by copolymerized monomers that contain pendant carboxylic acid groups...
  32. CONTROLLED RELEASE OF MACROMOLECULES
    Robert Langer; Fiscal Year: 2001
    ..of dehydration method, DNA packing, DNA hydration, and DNA conformation, (2) Identify new DNA stabilizing excipients or excipient combinations, 3) identify the principal non- enzymatic degradation pathways of supercoiled, nicked ..
  33. MIXED CRYSTAL GROWTH FOR BIOPHARMACEUTICAL STABILIZATION
    Bart Kahr; Fiscal Year: 1999
    ..The general aims of this R21 pilot project concern stabilization of biopharmaceutical (protein) drugs in excipients for pharmaceutical formulations that would have increased shelf line and not require refrigeration...
  34. FORMULATION FOR IMPROVED OPHTHALMIC ANTIBIOTIC EFFICACY
    S Chandrasekaran; Fiscal Year: 1990
    ..This Phase I proposal involves selecting the appropriate combination of polymers and other vehicle excipients to form a sustained release formulation compatible with a broad spectrum drug such as tobramycin, an anti-..
  35. Topical Microbicides for Prevention of STDs/HIV
    Sharon Hillier; Fiscal Year: 2003
    ..of hydrophilic and lipophilic substances across vaginal and cervical tissue, describe the effects of formulation excipients on normal flora organisms, genital pathogens and HIV, and employ basic pharmaceutical techniques to develop a ..
  36. Development of NNRTI's as Combination Microbicides
    Sharon Hillier; Fiscal Year: 2006
    ..In Project 3, Drs. Lisa Rohan and Charles Isaacs will seek to develop combinations of other active agents and excipients to be used with UC781. In Project 4, Dr...
  37. FORMULATION FOR MUCOSAL IMMUNIZATION AGAINST HIV
    Adrian Bot; Fiscal Year: 2001
    ..Variants engineered with immune modulatory excipients like mannose-receptor binding carbohydrates dendritic cell chemokines, Th1-promoting or IgA-inducing cytokines ..
  38. FLP-102: Rationally Engineered Antiviral Protein
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The preclinical data on FLP-102 will be essential to further explore the utility of this novel recombinant PAP mutant for Phase II. ..
  39. PHI 346: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Following successful completion of the Phase I in vivo efficacy studies, gel formulation of PHI-346 will be further explored as a vaginal dual-function microbicide in Phase II. ..
  40. Polymer Based Gene Delivery
    Alexander V Kabanov; Fiscal Year: 2010
    ..These studies will be conducted in collaboration with a co- investigator at Memorial Sloan Kettering Cancer Center who has expertise in pre-clinical and clinical DNA immunizations against malignant melanoma. ..
  41. PHI-443: Novel Non-Spermicidal Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2003
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of PHI-443 in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  42. Stampidine: A Novel Broad-Spectrum Anti-HIV Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ..Specific Aims 1 and 2 may provide the foundation for the clinical development of STAMP in Phase II studies as a safe, effective broad-spectrum anti-HIV microbicide without conception-inhibiting functions. ..
  43. 6th International Nanomedicine and Drug Delivery Symposium
    Alexander Kabanov; Fiscal Year: 2008
    ..e. graduate students and post-doctoral fellows) to present their research at the international level and interact with other new promising investigators and world-renowned scientists. [unreadable] [unreadable] [unreadable]..
  44. METVAN: A Novel Anticancer Agent
    OSMOND D CRUZ; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing METVAN for metastatic breast cancer and brain tumor patients. ..
  45. NOVEL CONTRACEPTIVES WITH ANTI-HIV ACTIVITY
    OSMOND D CRUZ; Fiscal Year: 2001
    ..The preclinical data on in vivo efficacies of WHI-05 and WHI-07 will be essential to further explore the utility of these novel drugs for clinical studies in human patients. ..
  46. Vanadocenes as a New Class of Spermicidal Drugs
    OSMOND D CRUZ; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. Fourth International Nanomedicine and Drug Delivery Symposium
    Alexander Kabanov; Fiscal Year: 2006
    ..In the final analysis achieving the aim of the conference will contribute to the development of novel nanoscale delivery technologies for diagnostics and therapeutics that address unmet clinical needs. [unreadable]..
  48. Interactions of Block Copolymers in Blood Brain Barrier
    Alexander Kabanov; Fiscal Year: 2006
    ..abstract_text> ..
  49. Phase II SBIR: WHI-07: A Novel Dual-Function Microbicide
    OSMOND D CRUZ; Fiscal Year: 2005
    ....
  50. Digoxin Chiral Isolates as Improved Pharmaceuticals
    John Somberg; Fiscal Year: 2005
    ..The advantage would be a treatment for AF that did not cause cardiac augmentation and vasoconstriction or a treatment for CHF that does not cause heart rate slowing or conduction disturbances. ..
  51. Combined Chemoprevention Using a Nanotechnology-based Therapeutic System
    Sunil Prabhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  52. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..The proposed research is expected to help transform this ideal into a reality. ..
  53. Elucidation of the Lipoxygenase-Mediated Pathway of Lun*
    PAUL MYRDAL; Fiscal Year: 2005
    ..abstract_text> ..
  54. Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome
    James Baraniuk; Fiscal Year: 2009
    ..These methods and biomarkers may be of diagnostic value. They will be useful for assessing longitudinal changes in disease severity, phenotype, or the effects of treatment. ..
  55. Virus-Receptor Interaction and CYP3A Expression
    Maria Croyle; Fiscal Year: 2005
    ....
  56. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    ..abstract_text> ..
  57. Non-Viral Vectors for Liver Gene Transfer
    Feng Liu; Fiscal Year: 2006
    ..The therapeutic effects on the metabolic disease on phenylketonuria (PKU) mice, will be examined after the PAH gene transfer using the approach in this proposal. ..
  58. Long-Circulating Polymer-Modified Liposomes
    Vladimir Torchilin; Fiscal Year: 2008
    ..abstract_text> ..
  59. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  60. EGFR Targeted Nanoparticles to Overcome Paclitaxel Resistant Breast Cancer
    RUSSELL MUMPER; Fiscal Year: 2009
    ..The innovation of this proposal relates to nanotemplate engineering of biocompatible nanoparticles, overcoming multi- drug resistance, and the use of nanotechnology to engineer a cell-targeted cancer therapy. ..
  61. Drug Transporters and the Disposition of ADHD Therapeutic Agents
    John S Markowitz; Fiscal Year: 2010
    ....