vehicles

Summary

Summary: A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)

Top Publications

  1. ncbi Pharmacological effects of formulation vehicles : implications for cancer chemotherapy
    Albert J ten Tije
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Pharmacokinet 42:665-85. 2003
  2. ncbi Effect of the difference in vehicles on gene expression in the rat liver--analysis of the control data in the Toxicogenomics Project Database
    Kayoko Takashima
    Toxicogenomics Project, National Institute of Health Sciences, Setagaya Ku, Tokyo, 158 8501, Japan
    Life Sci 78:2787-96. 2006
  3. ncbi The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins
    Yan Hua Xue
    School of Life Science and Technology, Tongji University, Shanghai 200092, China
    J Mater Sci Mater Med 19:1197-202. 2008
  4. ncbi Microbial susceptibility to calcium hydroxide pastes and their vehicles
    Brenda Paula Figueiredo de Almeida Gomes
    Dental School of Piracicaba, State University of Campinas, SP, Brazil
    J Endod 28:758-61. 2002
  5. ncbi Development of in situ thermosensitive drug vehicles for glaucoma therapy
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
    Biomaterials 24:2423-30. 2003
  6. ncbi Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat
    Jordan Ned Smith
    Battelle, Pacific Northwest Division, Richland, WA 99354, USA
    Toxicology 261:47-58. 2009
  7. pmc Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery
    Katherine W Ferrara
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Acc Chem Res 42:881-92. 2009
  8. ncbi Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)
    Jia You Fang
    Pharmaceutics Laboratory, Chang Gung University, Taoyuan, Taiwan
    Eur J Pharm Biopharm 70:633-40. 2008
  9. ncbi What determines drug solubility in lipid vehicles: is it predictable?
    Sagar S Rane
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA
    Adv Drug Deliv Rev 60:638-56. 2008
  10. ncbi Disposition kinetics of taxanes after intraperitoneal administration in rats and influence of surfactant vehicles
    Koichi Yokogawa
    Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Pharm Pharmacol 56:629-34. 2004

Detail Information

Publications271 found, 100 shown here

  1. ncbi Pharmacological effects of formulation vehicles : implications for cancer chemotherapy
    Albert J ten Tije
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Clin Pharmacokinet 42:665-85. 2003
    ..35) and polysorbate 80 (Tween) 80; polyoxyethylene-sorbitan-20-monooleate) are widely used as drug formulation vehicles, including for the taxane anticancer agents paclitaxel and docetaxel...
  2. ncbi Effect of the difference in vehicles on gene expression in the rat liver--analysis of the control data in the Toxicogenomics Project Database
    Kayoko Takashima
    Toxicogenomics Project, National Institute of Health Sciences, Setagaya Ku, Tokyo, 158 8501, Japan
    Life Sci 78:2787-96. 2006
    ..These results would be useful for usage of the database especially when drugs with different vehicle control are compared...
  3. ncbi The construction and characterization of layered double hydroxides as delivery vehicles for podophyllotoxins
    Yan Hua Xue
    School of Life Science and Technology, Tongji University, Shanghai 200092, China
    J Mater Sci Mater Med 19:1197-202. 2008
    ..We conclude that the higher tumor inhibition effects of PPT-LDH hybrids result from the inorganic drug delivery vehicle, LDHs...
  4. ncbi Microbial susceptibility to calcium hydroxide pastes and their vehicles
    Brenda Paula Figueiredo de Almeida Gomes
    Dental School of Piracicaba, State University of Campinas, SP, Brazil
    J Endod 28:758-61. 2002
    ..of some microorganisms commonly isolated from root canals to calcium hydroxide in combination with several vehicles by the agar diffusion method. Stainless-steel cylinders were placed on each inoculated agar medium...
  5. ncbi Development of in situ thermosensitive drug vehicles for glaucoma therapy
    Ging Ho Hsiue
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu 300, Taiwan
    Biomaterials 24:2423-30. 2003
    The goal of this research was to design thermosensitive drug vehicles for glaucoma therapy...
  6. ncbi Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat
    Jordan Ned Smith
    Battelle, Pacific Northwest Division, Richland, WA 99354, USA
    Toxicology 261:47-58. 2009
    ..been conducted in animals, where CPF has been administered via a variety of different exposure routes and dosing vehicles. This study compared chlorpyrifos (CPF) pharmacokinetics using oral, intravenous (IV), and subcutaneous (SC) ..
  7. pmc Lipid-shelled vehicles: engineering for ultrasound molecular imaging and drug delivery
    Katherine W Ferrara
    Department of Biomedical Engineering, University of California, Davis, California 95616, USA
    Acc Chem Res 42:881-92. 2009
    ..Lipid-shelled vehicles offer many opportunities for chemists and engineers; ultrasound-based applications beyond the few currently in ..
  8. ncbi Lipid nanoparticles as vehicles for topical psoralen delivery: solid lipid nanoparticles (SLN) versus nanostructured lipid carriers (NLC)
    Jia You Fang
    Pharmaceutics Laboratory, Chang Gung University, Taoyuan, Taiwan
    Eur J Pharm Biopharm 70:633-40. 2008
    ..The results showed that the entrapment of 8-MOP in nanoparticulate systems could minimize the permeation differentiation between normal and hyperproliferative skin compared to the free drug in an aqueous control...
  9. ncbi What determines drug solubility in lipid vehicles: is it predictable?
    Sagar S Rane
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA
    Adv Drug Deliv Rev 60:638-56. 2008
    ..Methods that can better take into account the specific as well as non-specific interactions between the solute and solvent, and the lipid microstructure, hold considerable promise for the future...
  10. ncbi Disposition kinetics of taxanes after intraperitoneal administration in rats and influence of surfactant vehicles
    Koichi Yokogawa
    Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Pharm Pharmacol 56:629-34. 2004
    ..We demonstrated that the disposition kinetics of taxanes after intraperitoneal administration to rats was strongly influenced, in a concentration-dependent manner, by the surfactant vehicle used, crEL or PS-80...
  11. ncbi The effect of type and concentration of vehicles on the dissolution rate of a poorly soluble drug (indomethacin) from liquisolid compacts
    Ali Nokhodchi
    Department of Pharmacy, School of Health and Life Sciences, King s College London, London, United Kingdom
    J Pharm Pharm Sci 8:18-25. 2005
    ..The object of the present study is to increase dissolution rate of indomethacin using liquisolid compacts...
  12. ncbi Nanoparticles as vehicles for delivery of photodynamic therapy agents
    Denise Bechet
    Centre de Recherche en Automatique de Nancy, Nancy University, Vandoeuvre les Nancy, France
    Trends Biotechnol 26:612-21. 2008
    ..Finally, we summarize exciting new results concerning the improvement of the photophysical properties of nanoparticles by means of biphotonic absorption and upconversion...
  13. ncbi Characterization of biodegradable drug delivery vehicles with the adhesive properties of leukocytes II: effect of degradation on targeting activity
    A O A Omolola Eniola
    Department of Chemical and Biomolecular Engineering, University of Pennsylvania, 311A Towne, 220 S, 33rd Street, Philadelphia, PA 19104, USA
    Biomaterials 26:661-70. 2005
    ....
  14. ncbi Development of novel poly(ethylene glycol)-based vehicles for gene delivery
    Anne H Schmieder
    Department of Biomedical Engineering and Center for Materials Innovation, Washington University, St Louis, Missouri 63130, USA
    Biotechnol Bioeng 96:967-76. 2007
    ..The results of this work demonstrate that PEG can be used as the backbone for gene delivery vehicles.
  15. ncbi Enhanced immunisation and expression strategies using bacterial spores as heat-stable vaccine delivery vehicles
    Nguyen Q Uyen
    School of Biological Sciences, Royal Holloway, University of London, Egham, Surrey TW20 0EX, UK
    Vaccine 25:356-65. 2007
    Spores of the gram positive bacterium Bacillus subtilis have been used as oral vaccine vehicles and have been shown to confer protection against tetanus in mice...
  16. ncbi Safety in work vehicles: a multilevel study linking safety values and individual predictors to work-related driving crashes
    Sharon Newnam
    Centre of Philanthropy and Nonprofit Studies, Queensland University of Technology, Carseldine, Queensland, Australia
    J Appl Psychol 93:632-44. 2008
    ..These results illustrate that perceptions of workplace safety values are transmitted across levels of the organization...
  17. ncbi Effect of vehicles and enhancers on the in vitro permeation of melatonin through hairless mouse skin
    Hye Sun Gwak
    Laboratory of Pharmaceutics, College of Pharmacy, Dongduk Women s University, Seoul, Korea
    Arch Pharm Res 25:392-6. 2002
    The effects of vehicles and penetration enhancers on the in vitro permeation of melatonin through dorsal hairless mouse skin were investigated...
  18. ncbi Perfluorocarbon compounds as vehicles for pulmonary drug delivery
    Hans Joachim Lehmler
    Research Scientist, University of Iowa, Department of Occupational and Environmental Health, Iowa City, IA 52242, USA
    Expert Opin Drug Deliv 4:247-62. 2007
    ..The use of perfluorocarbon compounds (PFCs) as drug delivery vehicles has been proposed to overcome these obstacles...
  19. ncbi Taxane-mediated antiangiogenesis in vitro: influence of formulation vehicles and binding proteins
    Sylvia S W Ng
    Molecular Pharmacology Section, Cancer Therapeutics Branch, Center for Cancer Research, and Clinical Pharmacology Research Core, Medical Oncology Clinical Research Unit, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
    Cancer Res 64:821-4. 2004
    ..used rat aortic rings and human umbilical vein endothelial cells to evaluate the influence of their formulation vehicles Cremophor EL and polysorbate 80, as well as serum binding proteins on taxane-mediated antiangiogenesis...
  20. ncbi In vitro antimicrobial activity of calcium hydroxide pastes and their vehicles against selected microorganisms
    Brenda Paula Figueiredo de Almeida Gomes
    Department of Restorative Dentistry, Endodontic Area, Dental School of Piracicaba, UNICAMP, Piracicaba, SP, Brazil
    Braz Dent J 13:155-61. 2002
    ..study was to investigate in vitro the antimicrobial activity of calcium hydroxide in combination with several vehicles against some microorganisms commonly isolated from root canals...
  21. ncbi Enhancing effects of monohexanoin and two other medium-chain glyceride vehicles on intestinal absorption of desmopressin (dDAVP)
    P D Lundin
    Department of Animal Physiology, Lund University, Sweden
    J Pharmacol Exp Ther 282:585-90. 1997
    ..The intestinal absorption enhancement of the nonapeptide [Mpa1,D-Arg8]vasopressin (dDAVP) by medium-chain glyceride vehicles was studied using an in vivo rat model...
  22. pmc Bacterial spores as vaccine vehicles
    Le H Duc
    School of Biological Sciences, Royal Holloway University of London, Egham, Surrey TW20 0EX, United Kingdom
    Infect Immun 71:2810-8. 2003
    For the first time, bacterial spores have been evaluated as vaccine vehicles. Bacillus subtilis spores displaying the tetanus toxin fragment C (TTFC) antigen were used for oral and intranasal immunization and were shown to generate ..
  23. ncbi Effects of vehicles and enhancers on transdermal delivery of melatonin
    H J Oh
    National Research Laboratory for Bioactives Delivery System, College of Pharmacy, Seoul National University, San 56-1, Shinlim-Dong, Kwanak-Ku, 151-742, Seoul, South Korea
    Int J Pharm 212:63-71. 2001
    For a more effective transdermal delivery of melatonin (MT), the effects of vehicles and enhancers on its skin permeation and lag time were evaluated...
  24. ncbi Nanoscale analysis of protein and peptide absorption: insulin absorption using complexation and pH-sensitive hydrogels as delivery vehicles
    Nicholas A Peppas
    Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Pharm Sci 29:183-97. 2006
    ..These synthetic materials can be used as unique systems or incorporated into existing drug delivery technologies that can aid in the removal or delivery of biomolecules and restore the natural profiles of compounds in the body...
  25. ncbi Transdermal delivery of ondansetron hydrochloride: effects of vehicles and penetration enhancers
    Hye Sun Gwak
    College of Pharmacy, Chosun University, Gwangju, South Korea
    Drug Dev Ind Pharm 30:187-94. 2004
    The effects of vehicles and penetration enhancers on the in vitro permeation of ondansetron hydrochloride (OS) across dorsal hairless mouse skins were investigated...
  26. pmc Dynamic imaging of arginine-rich heart-targeted vehicles in a mouse model
    Hua Zhang
    Department of Biomedical Engineering, University of California, Davis, CA 95616, USA
    Biomaterials 29:1976-88. 2008
    ..The rapid and efficient targeting of these particles can be exploited in drug and gene delivery systems and with dynamic positron emission tomography provides a model system to optimize targeting of engineered particles...
  27. ncbi In vivo generation of cytotoxic T cells from epitopes displayed on peptide-based delivery vehicles
    Kim S Kawamura
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    J Immunol 168:5709-15. 2002
    ..We report the design of branched peptide delivery vehicles, termed loligomers, that facilitate the import, processing, and presentation of CTL epitopes onto nascent MHC ..
  28. ncbi Influence of different vehicles on the pH of calcium hydroxide pastes
    María Gabriela Pacios
    Catedra de Quimica Biologica, Facultad de Odontologia, Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina
    J Oral Sci 46:107-11. 2004
    ..The type of vehicle was shown to influence the final pH of the pastes. However, the alkalinity of all pastes was maintained over time under the experimental conditions...
  29. ncbi Effect of commonly used vehicles on gastrointestinal, renal, and liver function in rats
    Sabine Pestel
    Group General Pharmacology, Drug Discovery Support, Boehringer Ingelheim Pharma GmbH and Co KG, D 88397 Biberach an der Riss, Germany
    J Pharmacol Toxicol Methods 54:200-14. 2006
    ..Various solubilizing agents may be used, but each have their own pharmacological effects. We investigated the effects of selected vehicles having different chemical characteristics on gastrointestinal, renal, and liver function.
  30. pmc An evaluation of disinfectants for the sanitation of porcine reproductive and respiratory syndrome virus-contaminated transport vehicles at cold temperatures
    Scott Dee
    Swine Disease Eradication Center, 385 C Animal Science Veterinary Medicine Building, University of Minnesota College of Veterinary Medicine, 1988 Fitch Avenue, St Paul, Minnesota 55108, USA
    Can J Vet Res 69:64-70. 2005
    ..In contrast, trailers treated with disinfectant and water were frozen within 60 min at -20 degrees C, and decontamination was not successful...
  31. ncbi Study and description of hydrogels and organogels as vehicles for cosmetic active ingredients
    M E Morales
    Pharmacy and Pharmaceutical Technology Department, School of Pharmacy, University of Granada, 18071 Granada, Spain
    J Cosmet Sci 60:627-36. 2009
    ..This paper describes the design of hydrogels and pluronic-lecithin organogels elaborated as vehicles of Aloe vera (Aloe vera linné) and Hydrocotyle asiatica (Centella asiatica) for the treatment of cellulite...
  32. ncbi Self-assembled particles of an elastin-like polymer as vehicles for controlled drug release
    R Herrero-Vanrell
    Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, Complutense University UCM, Avda Complutense s n, 28040 Madrid, Spain
    J Control Release 102:113-22. 2005
    ..This work explored the use of self-assembled poly(VPAVG) micro- and nanoparticles as vehicles for the controlled release of the model drug dexamethasone phosphate (DMP)...
  33. ncbi Nonviral delivery vehicles for use in short hairpin RNA-based cancer therapies
    John S Vorhies
    Mary Crowley Medical Research Center, 1717 Main St, Suite 6000, Dallas, TX 75201, USA
    Expert Rev Anticancer Ther 7:373-82. 2007
    ..Nonviral delivery vehicles that are relevant for shRNA delivery into humans belong to a group of substances about which significant ..
  34. ncbi Patients with psoriasis prefer solution and foam vehicles: a quantitative assessment of vehicle preference
    Tamara Salam Housman
    Department of Dermatology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cutis 70:327-32. 2002
    Psoriasis patients' acceptance of the vehicles used in topical therapy contributes to adherence to treatment plans and outcomes, but patient preferences for different vehicles have not been assessed...
  35. ncbi Influence of administration vehicles and drug formulations on the pharmacokinetic profile of lamotrigine in rats
    M M Castel-Branco
    Laboratory of Pharmacology, Faculty of Pharmacy, Coimbra University, Coimbra, Portugal
    Fundam Clin Pharmacol 16:331-6. 2002
    Given that administration vehicles and drug formulations can affect drug bioavailability, their influence on the pharmacokinetic profile of lamotrigine (LTG), a new-generation anti-epileptic drug, was studied in rats...
  36. ncbi DNA nanoparticles and development of DNA delivery vehicles for gene therapy
    Veena Vijayanathan
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903, USA
    Biochemistry 41:14085-94. 2002
    ..Therefore, several laboratories are involved in the development of nonviral DNA delivery vehicles. These vehicles include polyamines, polycationic lipids, and neutral polymers, capable of condensing DNA to ..
  37. ncbi An agar diffusion comparison of the antimicrobial effect of calcium hydroxide at five different concentrations with three different vehicles
    Michael L Blanscet
    Naval Postgraduate Dental School, Bethesda, MD, USA
    J Endod 34:1246-8. 2008
    ..of this study was to determine if varying the percent (by weight) of aqueous calcium hydroxide or using different vehicles had an effect on its antibacterial efficacy against common endodontic pathogens in a pour plate/traditional ..
  38. ncbi Evaluation of synthetic/reconstituted high-density lipoproteins as delivery vehicles for paclitaxel
    Walter J McConathy
    Department of Internal Medicine, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Anticancer Drugs 19:183-8. 2008
    ..Studies with mice showed that the rHDL/PTX nanoparticles were substantially better tolerated than the corresponding dosages of either Taxol or Abraxane...
  39. ncbi Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin
    D J Chatterjee
    College of Pharmacy, University of Michigan, Ann Arbor 48109, USA
    Pharm Res 14:1058-65. 1997
    ..The objective of this study was to determine the effect of vehicles and penetration enhancers on the percutaneous absorption of MTX and its analog edatrexate (EDAM), and develop ..
  40. ncbi Biophysical aspects of using liposomes as delivery vehicles
    Anne S Ulrich
    Friedrich Schiller University of Jena, Institute of Molecular Biology, Germany
    Biosci Rep 22:129-50. 2002
    ..size and in the physical parameters of the lipids affords an attractive potential for constructing tailor-made vehicles for a wide range of applications...
  41. pmc Escherichia coli serotype O157:H7: novel vehicles of infection and emergence of phenotypic variants
    P Feng
    U S Food and Drug Administration, Washington, D C 20204, USA
    Emerg Infect Dis 1:47-52. 1995
    ..The implication of acidic foods as vehicles of infection has dispelled the concept that low-pH foods are safe...
  42. ncbi Post-pegylated lipoplexes are promising vehicles for gene delivery in RPE cells
    L Peeters
    Laboratory of General Biochemistry and Physical Pharmacy, Ghent University, Harelbekestraat 72, 9000 Ghent, Belgium
    J Control Release 121:208-17. 2007
    ....
  43. ncbi Acute local tolerability of acidic aqueous vehicles delivered via Respimat Soft Mist Inhaler in hyperreactive asthma patients
    V Leclerc
    ABAC, Paris, France
    Respiration 74:691-6. 2007
    ..Acidic inhalers can be associated with increased adverse reactions...
  44. ncbi Micelles of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization and controlled delivery of cyclosporine A
    Hamidreza Montazeri Aliabadi
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    J Control Release 104:301-11. 2005
    ..of methoxy poly(ethylene oxide)-b-poly(epsilon-caprolactone) (PEO-b-PCL) were investigated as alternative vehicles for the solubilization and delivery of CsA...
  45. ncbi The pH changes of calcium hydroxide mixed with six different vehicles
    Ali Cagin Yucel
    Department of Restorative Dentistry, Ondokuz Mayis University, Faculty of Dentistry, Samsun, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:712-7. 2007
    ..The aim of this study was to determine the pH values of calcium hydroxide mixed with sterile saline, glycerin, Xylocaine pump spray, Citanest Octapressin, 0.2% chlorhexidine solution, and Ultracaine DS...
  46. pmc Porous nanoparticle supported lipid bilayers (protocells) as delivery vehicles
    Juewen Liu
    Center for Micro Engineered Materials, University of New Mexico, Albuquerque, New Mexico 87106, USA
    J Am Chem Soc 131:1354-5. 2009
    ..Compared to some other nanoparticle systems, protocells provide a simple construct for cargo loading, sealing, delivery, and release. They promise to serve as useful vectors in nanomedicine...
  47. ncbi Transdermal delivery of capsaicin derivative-sodium nonivamide acetate using microemulsions as vehicles
    Yaw Bin Huang
    Graduate Institute of Clinical Pharmacy, Kaohsiung Medical University, 100 Shih Chuan 1st Road, Kaohsiung City 80708, Taiwan
    Int J Pharm 349:206-11. 2008
    ..However, the permeability of SNA delivered from microemulsion was higher than SNA from volatile vehicles (pH 4...
  48. ncbi Transdermal delivery of ketorolac tromethamine: effects of vehicles and penetration enhancers
    Young Ah Cho
    College of Pharmacy, Chosun University, Gwangju, Korea
    Drug Dev Ind Pharm 30:557-64. 2004
    The effects of vehicles and penetration enhancers on the in vitro permeation of ketorolac tromethamine (KT) across excised hairless mouse skins were investigated...
  49. ncbi Lipid nano/submicron emulsions as vehicles for topical flurbiprofen delivery
    Jia You Fang
    Graduate Institute of Natural Products, Chang Gung University, Tao Yuan, Taiwan
    Drug Deliv 11:97-105. 2004
    ..The incorporation of oleic acid also produced skin disruption. The results in the present study suggest the feasibility of lipid emulsions for the topical delivery of flurbiprofen...
  50. ncbi In vitro evaluation of the susceptibility of endodontic pathogens to calcium hydroxide combined with different vehicles
    Morgana Eli Vianna
    Department of Restorative Dentistry, Area of Endodontics, Faculty of Dentistry of Piracicaba, State University of Campinas UNICAMP, Piracicaba, SP, Brazil
    Braz Dent J 16:175-80. 2005
    ..to investigate in vitro the antimicrobial activity of calcium hydroxide [Ca(OH)2] in combination with different vehicles against endodontic pathogens. For such purpose, a broth dilution test was performed...
  51. ncbi Lipid-based microtubular drug delivery vehicles
    N J Meilander
    Biomaterials, Cell and Tissue Engineering Laboratory, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-7207, USA
    J Control Release 71:141-52. 2001
    ..Our microtubule-hydrogel system is useful for applications where sustained release without contact between agent and organic solvents is desired...
  52. ncbi Transdermal delivery of tadalafil. I. Effect of vehicles on skin permeation
    Gamal M El Maghraby
    Department of Pharmaceutics, College of Pharmacy, Kayyali Chair for Pharmaceutical Industry, King Saud University, Riyadh, Saudi Arabia
    Drug Dev Ind Pharm 35:329-36. 2009
    ..The vehicles were used neat or in selected binary combinations and were evaluated for drug solubilization and transdermal ..
  53. pmc S-nitrosothiol-modified dendrimers as nitric oxide delivery vehicles
    Nathan A Stasko
    Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Biomacromolecules 9:834-41. 2008
    ..storage, the dendritic effects exerted on nitrosothiol stability and reactivity, and the utility of dendrimers as drug delivery vehicles highlight the potential of these constructs as clinically useful S-nitrosothiol-based therapeutics.
  54. ncbi Microemulsions and nanoemulsions: novel vehicles for whitening cosmeceuticals
    Prapaporn Boonme
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla 90112, Thailand
    J Biomed Nanotechnol 5:373-83. 2009
    ..To increase efficiency, novel vehicles are necessary for skin penetration enhancement of these agents...
  55. ncbi Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin
    Concepcion Lecaroz
    Department of Microbiology, University of Navarra, Pamplona, Spain
    J Microencapsul 23:782-92. 2006
    ..In summary, microspheres made of 502H, 503H and 75:25H and nanoparticles of 502H showed the best potential properties for systemic use in the treatment of intra-cellular gentamicin-susceptible pathogens...
  56. ncbi Reconstructed epidermis and full-thickness skin for absorption testing: influence of the vehicles used on steroid permeation
    Monika Schäfer-Korting
    Freie Universtät Berlin, Institut für Pharmazie Pharmakologie and Toxikologie, Konigin Luise Strasse 2 4, Berlin, Germany
    Altern Lab Anim 36:441-52. 2008
    ..In conclusion, RHE and skin preparations may be useful in the development of topical dermatics, and in the framework of hazard analysis of toxic compounds and their various formulations...
  57. ncbi Nerve guidance channels as drug delivery vehicles
    Alexandra Piotrowicz
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St, Toronto, Ont, Canada
    Biomaterials 27:2018-27. 2006
    ..Notwithstanding, the liquid-liquid centrifugal casting process is promising for localized and controlled release of multiple factors that are key to tissue regeneration...
  58. ncbi Nonclinical vehicle use in studies by multiple routes in multiple species
    Shayne C Gad
    Gad Consulting Services, Cary, North Carolina 27518, USA
    Int J Toxicol 25:499-521. 2006
    The laboratory toxicologist is frequently faced with the challenge of selecting appropriate vehicles or developing utilitarian formulations for use in in vivo nonclinical safety assessment studies...
  59. ncbi Anionic PAMAM dendrimers as drug delivery vehicles for transition metal-based anticancer drugs
    Michelle J Pisani
    School of Physical, Environmental and Mathematical Sciences, University College, University of New South Wales, Northcott Drive, Campbell, ACT 2600, Australia
    J Inorg Biochem 103:373-80. 2009
    The use of anionic half-generation poly(amidoamine) dendrimers as drug delivery vehicles for [Pt(S,S-dach)(5,6-Me(2)phen)](2+) (56MESS) (where S,S-dach=1S,2S-diaminocyclohexane; 5,6-Me(2)phen=5,6-dimethyl-1,10-phenanthroline) and [{Delta,..
  60. pmc Tissue distribution and kinetics of endogenous porphyrins synthesized after topical application of ALA in different vehicles
    A Casas
    Centro de Investigaciones sobre Porfirinas y Porfirias, FCEyN University of Buenos Aires and CONICET Ciudad Universitaria, Capital Federal, Argentina
    Br J Cancer 81:13-8. 1999
    ..determine the kinetics of porphyrin generation in tissues after topical application of ALA delivered in different vehicles on the skin overlying the tumour and normal skin of mice...
  61. ncbi Ex vivo study of transdermal permeation of four diclofenac salts from different vehicles
    Paola Minghetti
    Istituto di Chimica Farmaceutica e Tossicologica, Universita degli Studi di Milano, Milano, Italy
    J Pharm Sci 96:814-23. 2007
    ..Aqueous formulations containing diclofenac salt with an organic base appear to be the best combination to promote permeation in topical applications...
  62. ncbi Effect of vehicles and penetration enhancers on the in vitro percutaneous absorption of celecoxib through human skin
    G Yener
    Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey
    Pharmazie 58:330-3. 2003
    ..Since celecoxib creates some gastrointestinal disturbances, topical formulations of celecoxib preferably in gel form including 5% oleic acid could be suggested as an alternative...
  63. ncbi Effect of vehicles and enhancers on the topical delivery of cyclosporin A
    Hongzhuo Liu
    School of Pharmaceutics, Shenyang Pharmaceutical University, Wen Hua RD NO 103, Shenyang 110016, People s Republic of China
    Int J Pharm 311:182-6. 2006
    ..The purpose of this study was to investigate the effect of various vehicles and enhancers on the topical delivery across rat skin...
  64. pmc Cholesterol transport from liposomal delivery vehicles
    Azadeh Kheirolomoom
    Department of Biomedical Engineering, University of California, 451 East Health Sciences Drive, Davis, CA 95616, USA
    Biomaterials 28:4311-20. 2007
    Rapid internalization of drugs from delivery vehicles via non-endocytotic pathways is an important goal...
  65. ncbi Nanodisks: hydrophobic drug delivery vehicles
    Robert O Ryan
    Oakland Research Institute, Children s Hospital, Center for Prevention of Obesity, Diabetes and Cardiovascular Disease, 5700 Martin Luther King Jr Way, Oakland CA 94609, USA
    Expert Opin Drug Deliv 5:343-51. 2008
    ..can proceed in the presence of exogenous hydrophobic biomolecules, resulting in the formation of novel transport vehicles termed nanodisks (NDs)...
  66. pmc Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors
    Xiaoping Duan
    Division of Pediatrics, The University of Texas M D Anderson Cancer, Department of Cancer Biology, Houston, Texas 77030, USA
    Cancer 115:13-22. 2009
    This study evaluated the therapeutic efficacy of interleukin 12 (IL-12) gene therapy in Ewing sarcoma and whether murine mesenchymal stem cells (MSCs) could serve as vehicles for IL-12 gene delivery.
  67. ncbi Effect of ethanol and isopropyl myristate on the availability of topical terbinafine in human stratum corneum, in vivo
    I Alberti
    Centre Interuniversitaire de Recherche et d'Enseignement 'Pharmapeptides, Campus Universitaire, Parc d'Affaires International, F-74166, Archamps, France
    Int J Pharm 219:11-9. 2001
    ..Conclusions: While D/L(2) for TBF derived from the three vehicles remained essentially constant, the drug's partitioning into the SC was significantly higher from formulations ..
  68. ncbi Conformational stability and antibody response to the 18kDa heat-shock protein formulated into different vehicles
    M H Costa
    Laboratório de Microesferas e lipossomos Centro de Biotecnologia, Butantan, Brasil
    Appl Biochem Biotechnol 73:19-28. 1998
    ..The copolymer 18kDa-hsp-BSA conferred a high titer of antibody in injected mice, and persisted 70 d after immunization. This approach should prove very useful for designing more effective vaccines by using 18kDa-hsp as carrier protein...
  69. ncbi Cellular vehicles for cancer gene therapy: current status and future potential
    Larisa Pereboeva
    Division of Human Gene Therapy, Department of Medicine, The Gene Therapy Center, BMRII 572, University of Alabama at Birmingham, 901 19th Street S, Birmingham, AL 35294, USA
    BioDrugs 18:361-85. 2004
    ..Along with different viral and non-viral vector systems, mammalian cells have also been considered as vehicles for delivery of anti-cancer therapeutics...
  70. ncbi Membrane-coated fiber array approach for predicting skin permeability of chemical mixtures from different vehicles
    Jim E Riviere
    Center for Chemical Toxicology Research and Pharmacokinetics CCTRP, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA
    Toxicol Sci 99:153-61. 2007
    ..These results suggested that the experimentally based MCF array approach can be used to predict skin absorption from chemical mixtures in different vehicles or formulations.
  71. pmc Driving delivery vehicles with ultrasound
    Katherine W Ferrara
    Department of Biomedical Engineering, 451 Health Sciences Drive, University of California, Davis, CA 95616, USA
    Adv Drug Deliv Rev 60:1097-102. 2008
    ..In this commentary, the identified mechanisms, delivery vehicles, applications and current bottlenecks for translation of these techniques are summarized.
  72. ncbi Effect of vehicles on the transdermal delivery of melatonin across porcine skin in vitro
    L Kikwai
    College of Pharmacy and Pharmaceutical Sciences, Florida A and M University, Tallahassee, FL 32307, USA
    J Control Release 83:307-11. 2002
    ..The purpose of this study was to investigate the effect of various vehicles on the in vitro permeation of melatonin across porcine skin...
  73. ncbi Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles
    Kavita M Gupta
    Department of Bioengineering, University of Utah, Biopolymers Research Building, 20 S 2030 E Salt Lake City, Utah 84112, USA
    J Pharm Sci 96:670-81. 2007
    ....
  74. ncbi The role of branched polyesters and their modifications in the development of modern drug delivery vehicles
    Lea Ann Dailey
    Department of Pharmaceutics and Biopharmacy, Philipps University Marburg, Ketzerbach 63, 35037 Marburg, Germany
    J Control Release 101:137-49. 2005
    ..class of biodegradable polymers showing significant potential for the development of a variety of drug delivery vehicles. The amphiphilic character and the resulting increase in hydrophilicity of this class of polymers provide ..
  75. ncbi In vitro antimicrobial activity of calcium hydroxide mixed with different vehicles against Enterococcus faecalis and Candida albicans
    B Tugba Turk
    Division of Endodontology, School of Dentistry, Ege University, Izmir, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 108:297-301. 2009
    ....
  76. ncbi Microemulsions as transdermal drug delivery vehicles
    Anna Kogan
    Casali Institute of Applied Chemistry, The Institute of Chemistry, Givat Ram Campus, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Adv Colloid Interface Sci 123:369-85. 2006
    ....
  77. ncbi Calcium hydroxide's association with different vehicles: In vitro action on some dentinal components
    María Gabriela Pacios
    Catedra de Quimica Biologica, Facultad de Odontologia, Universidad Nacional de Tucuman, San Miguel de Tucuman, Argentina
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 96:96-101. 2003
    Calcium hydroxide, Ca(OH)(2), is a common intracanal medicament. Ca(OH)(2) powder can be mixed with different vehicles and used as a paste for temporary intracanal treatment...
  78. ncbi Alginate-whey protein granular microspheres as oral delivery vehicles for bioactive compounds
    Lingyun Chen
    Institut de recherche sur les nutraceutiques et les aliments fonctionnels INAF STELA, Faculté des sciences de l agriculture et de l alimentation, Universite Laval, Pavillon Paul Comtois, Sainte Foy, Que, Canada G1K 7P4
    Biomaterials 27:4646-54. 2006
    ..Riboflavin release in SGF and in SIF without pancreatin followed the Higuchi diffusion model while release in SIF in the presence of pancreatin was attributed to WPI granule degradation...
  79. ncbi Vehicles for oligonucleotide delivery to tumours
    Crispin R Dass
    Johnson and Johnson Research, Strawberry Hills, Australia
    J Pharm Pharmacol 54:3-27. 2002
    ..A discourse on how the chemical and physical properties of these carriers may affect the uptake of ONs into cells, particularly in-vivo, forms a major basis of this review...
  80. ncbi Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performance
    Snezana Savic
    Faculty of Pharmacy, Institute of Pharmaceutical Technology and Cosmetology, Belgrade Vojvode Stepe 450, 11221 Belgrade, Serbia
    J Pharm Sci 98:2073-90. 2009
    ..The results have shown that the emulsion vehicles consisted of a complex colloidal structure of lamellar liquid crystalline and lamellar gel crystalline type...
  81. ncbi Assessment of the palatability of vehicles for activated charcoal in pediatric volunteers
    Damon Dagnone
    University of Western Ontario, London, Ontario, Canada
    Pediatr Emerg Care 18:19-21. 2002
    To evaluate the palatability of 4 common flavoring vehicles (water, chocolate milk [CM], orange juice [OJ], and cola) combined with activated charcoal (AC) in pediatric volunteers.
  82. ncbi Vehicles based on a sugar surfactant: Colloidal structure and its impact on in vitro/in vivo hydrocortisone permeation
    Snezana D Savić
    Institute of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia and Montenegro
    Int J Pharm 320:86-95. 2006
    ..structure of lamellar liquid crystalline and lamellar gel crystalline type was deduced for sugar surfactant-based vehicles. In dependence on surfactant/water/oil ratio, several thermodynamically variable fractions of water were ..
  83. ncbi Probing the effect of vehicles on topical delivery: understanding the basic relationship between solvent and solute penetration using silicone membranes
    S E Cross
    Department of Medicine, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia
    Pharm Res 18:999-1005. 2001
    ..flux, with changes in both diffusivity and partitioning of hydrocortisone observed for the different solvent vehicles. CONCLUSIONS: A simple structure-based predictive model can be applied to the sorption of solvents into silicone ..
  84. ncbi Pectin gel vehicles for controlled fragrance delivery
    Linshu Liu
    Crop Conversion Science and Engineering Unit, Eastern Regional Research Center, Agricultural Research Service, U S Department of Agriculture, Wyndmoor, Pennsylvania 19038, USA
    Drug Deliv 12:149-57. 2005
    ..The pectin/calcium microparticles are promising materials for controlled fragrance release...
  85. ncbi Targeted gene delivery to skin cells in vivo: a comparative study of liposomes and polymers as delivery vehicles
    Nalini Raghavachari
    McArdle Laboratory for Cancer Research, University of Wisconsin, 1400 University Avenue, Madison, WI 53706, USA
    J Pharm Sci 91:615-22. 2002
    ..This simple, noninvasive technique of using nonionic liposomes to deliver biomolecules provides an efficient delivery strategy for gene therapy and drug delivery to the dermal organ site...
  86. ncbi Preclinical evaluation of alternative pharmaceutical delivery vehicles for paclitaxel
    Walter J Loos
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, 3008 AE Rotterdam, The Netherlands
    Anticancer Drugs 13:767-75. 2002
    ..including Sorporol 230, Sorporol 120Ex, Aceporol 345-T, Aceporol 460 and Riciporol 335, as potential new delivery vehicles for paclitaxel were investigated, since recent studies have shown that the paclitaxel delivery vehicle Cremophor ..
  87. ncbi Enhancement of transdermal delivery of theophylline using microemulsion vehicle
    X Zhao
    Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210038, PR China
    Int J Pharm 327:58-64. 2006
    ..65-fold higher than that of oral solution administration. These studies showed that microemulsion system of theophylline might be promising vehicles for the transdermal delivery of theophylline.
  88. ncbi Microemulsions as topical delivery vehicles for the anti-melanoma prodrug, temozolomide hexyl ester (TMZA-HE)
    Panassaya Suppasansatorn
    School of Life and Health Sciences, Aston University, Birmingham B4 7ET, UK
    J Pharm Pharmacol 59:787-94. 2007
    ..Therefore IPM ME systems are promising for transdermal delivery of TMZA-HE and OA ME systems may be a suitable choice for a topical formulation of TMZA-HE...
  89. ncbi Effect of vehicles on topical application of aloe vera and arnica montana components
    Valentina Bergamante
    Dipartimento di Scienze Farmaceutiche, Universita di Bologna, Bologna, Italy
    Drug Deliv 14:427-32. 2007
    ..This is in accordance with the necessity to avoid this process, since human skin fibroblasts can metabolize absorbed aloin into a structurally related compound that increases the sensitivity of skin to ultraviolet light...
  90. ncbi Effect of propylene glycol on ibuprofen absorption into human skin in vivo
    Christophe Herkenne
    School of Pharmaceutical Sciences, University of Geneva, 30 quai E Ansermet, CH 1211 Geneva 4, Switzerland
    J Pharm Sci 97:185-97. 2008
    ....
  91. ncbi Modulation of dihydroavenanthramide D release and skin penetration by 1,2-alkanediols
    Sandra Heuschkel
    Institute of Pharmacy, Martin Luther University Halle Wittenberg, Wolfgang Langenbeck Strasse 4, Halle Saale, Germany
    Eur J Pharm Biopharm 70:239-47. 2008
    ..Due to their favorable biopharmaceutical and technological properties, longer chain 1,2-alkanediols represent a valuable class of ingredients for dermal products...
  92. ncbi Effect of poly(amidoamine) (PAMAM) dendrimer on skin permeation of 5-fluorouracil
    Venkata Vamsi K Venuganti
    Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, SD 57007, USA
    Int J Pharm 361:230-8. 2008
    ..Three different vehicles were used, including phosphate buffer (PB), mineral oil (MO) and isopropyl myristate (IPM)...
  93. ncbi Release characteristics of anionic drug compounds from liquid crystalline gels. Part II. The effects of ion pairing and buffering on the passive delivery of anionic drugs across non-rate-limiting membranes
    Dara Fitzpatrick
    Department of Chemistry, University College Cork, Ireland
    Int J Pharm 311:139-46. 2006
    ..Vehicle preparation was also found to influence the degree of ion-pair association. The inclusion of a similarly charged enhancer (oleic acid) to the drug was found not to impede the diffusion of the drug from the gels...
  94. ncbi Combined effects of iontophoretic and chemical enhancement on drug delivery. II. Transport across human and murine skin
    L M A Nolan
    School of Chemistry, Trinity College, Dublin 2, Ireland
    Int J Pharm 341:114-24. 2007
    ..The investigation also indicated that the barrier properties of the skin recover following the constant current iontophoresis in the presence of oleic or lauric acids...
  95. ncbi How does the type of vehicle influence the in vitro skin absorption and elimination kinetics of terpenes?
    Krzysztof Cal
    Department of Pharmaceutical Technology, Medical University of Gdansk, Hallera 107, 80 416 Gdansk, Poland
    Arch Dermatol Res 297:311-5. 2006
    ..kinetics of two terpenes, namely linalool and terpinen-4-ol, incorporated in three different dermatological vehicles: oily solution, hydrogel and o/w emulsion...
  96. ncbi In Vitro penetration of a novel oxaborole antifungal (AN2690) into the human nail plate
    Xiaoying Hui
    Department of Dermatology, University of California San Francisco, Box 0989, 90 Medical Center Way, San Francisco, California 94143, USA
    J Pharm Sci 96:2622-31. 2007
    ..four oxaboroles that led to the selection of AN2690, (ii) the results of the nail penetration of AN2690 from four vehicles, and (iii) the nail penetration of AN2690 in its chosen vehicle compared to a commercial control, ciclopirox...
  97. ncbi Liposomal delivery of hydrophobic weak acids: enhancement of drug retention using a high intraliposomal pH
    Vijay Joguparthi
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40506, USA
    J Pharm Sci 97:433-54. 2008
    ..Simulations were conducted to explore the role of membrane binding, intravesicular pH, and carbonate buffer concentration in successful utilization of the pH gradient strategy for hydrophobic weak acids...
  98. ncbi Skin permeation of lidocaine from crystal suspended oily formulations
    Rakan Matsui
    H and BC Research Center, Shiseido Research Center, Yokohama, Japan
    Drug Dev Ind Pharm 31:729-38. 2005
    ..Finally, mathematical analysis was done to evaluate the effect of BO-2, and it was shown that BO-2 improved the LID solubility in stratum corneum lipids to efficiently enhance the LID permeation through skin...
  99. ncbi Feasibility studies of dermal delivery of paclitaxel with binary combinations of ethanol and isopropyl myristate: role of solubility, partitioning and lipid bilayer perturbation
    Ramesh Panchagnula
    Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, Phase X, Mohali 160062, Punjab, India
    Farmaco 60:894-9. 2005
    ..Epidermal and dermal partitioning was carried from PCL saturated vehicles. Skin permeation of PCL was studied using the rat skin...
  100. ncbi An integrated pharmacokinetic and imaging evaluation of vehicle effects on solute human epidermal flux and, retention characteristics
    G Winckle
    Therapeutics Research Unit, Southern Clinical School, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Pharm Res 25:158-66. 2008
    Our understanding of the differential effects of topically applied vehicles on solute partitioning and diffusion within the skin is presently limited...
  101. ncbi Vehicle and enhancer effects on human skin penetration of aminophylline from cream formulations: evaluation in vivo
    Lai Hao Wang
    Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan 71710, Taiwan R O C
    J Cosmet Sci 58:245-54. 2007
    ..Microemulsions containing 10% jojoba oil and 30% corn germ oil were found to be superior vehicles for the percutaneous absorption of aminophylline...

Research Grants76

  1. Ligand Directed Transdermal siRNA Delivery to Improve Wound Healing
    David M Evans; Fiscal Year: 2012
    ..This project will seek to improve upon this observation by developing novel topical delivery vehicles that can further penetrate across the tissue within a wound...
  2. Nanoparticle Coupled Antioxidants for Respiratory Illness in Veterans
    RODNEY JON SCHLOSSER; Fiscal Year: 2013
    ..exposure to diesel exhaust particles (DEP) occurs from the extensive use of diesel engines in military vehicles and equipment...
  3. Phage Display for Improved Peptide-based Tumor Targeting and Imaging Agents
    Susan L Deutscher; Fiscal Year: 2013
    ..Thus, finding new cancer targeting vehicles and cancer-associated antigens is a central goal of the field...
  4. Validation of a Novel NF-kB Inhibitor in Inflammatory Bowel Disease
    Anthony Blikslager; Fiscal Year: 2013
    ..agents that can be delivered locally and inhibit their targets in intestinal immune cells and, 2) lack of vehicles to carry these agents to the site of inflammation with minimal degradation in the GI tract...
  5. Gold Nanoparticle Assisted Delivery of Cancer Vaccines and Immune Stimulants
    Adam Lin; Fiscal Year: 2013
    ..Thus, there is a profound need for designing delivery vehicles for vaccine peptides...
  6. Stem cell-mediated delivery of neurotrophic factors for treatment of glaucoma
    Donald S Sakaguchi; Fiscal Year: 2010
    ..Engineered MSCs are especially attractive as neurotrophic factor delivery vehicles for several reasons...
  7. Pharmacology of Antiretroviral Nanoparticle Micelles
    Christopher J Destache; Fiscal Year: 2010
    ..Mononuclear phagocytes serve as not only as early reservoirs but also vehicles for dissemination for HIV-1...
  8. Breakthroughs to advance the in vitro propagation of human noroviruses
    Qiuhong Wang; Fiscal Year: 2010
    ..dose, environmental resistance, strain diversity, shedding from asymptomatic individuals and varied transmission vehicles render HuNoVs highly contagious prompting their classification as category B biodefense pathogens by the NIAID, ..
  9. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..S. troops inside heavily armored vehicles. In fact, "One in Six Wounded in Afghanistan War Have Spinal Cord Injuries" (The Spinal Post, Nov.11, 2009")...
  10. Osteoclasts from pluripotent stem cells as vectors to modify bone marrow environm
    Hector L Aguila; Fiscal Year: 2010
    ..Third, their localization make osteoclasts excellent vehicles for the potential manipulation of microenvironments with important outcomes for the development of innovative ..
  11. MECHANISMS OF SALMONELLA INVASION AND TRANSMIGRATION
    James E Casanova; Fiscal Year: 2013
    ..However, Salmonella can also use phagocytes as vehicles for their systemic dissemination, and the success or failure of the host response lies in the balance between ..
  12. Chemoprevention of Head &Neck Cancer Using Controlled Release Polymers
    Susan R Mallery; Fiscal Year: 2013
    ..these studies is to identify effective cancer-preventing compounds for placement in controlled release delivery vehicles for implantation at the surgery site to prevent local treatment failures and inhibit development of new cancers...
  13. Pre-clinical testing of necrostatin as a potential small molecule for the treatme
    SERGE E PRZEDBORSKI; Fiscal Year: 2012
    ..SA-2 will assess Nec-1 and its inactive structural analogue Nec-1ia solubility and stability in suitable vehicles for chronic in vivo use, and their central nervous system penetration, pharmacokinetics, routes of administration ..
  14. Mesenchymal Stem Cells for Treatment of Retinal Diseases
    Martin L Katz; Fiscal Year: 2011
    ..be undertaken to determine whether genetically modified stem cells isolated from the bone marrow can be used as vehicles for long-term, sustained delivery of therapeutic agents to eye tissues of people with a variety of retinal ..
  15. Interphotoreceptor Matrix Based Cell Delivery Vehicle for Retinal Regeneration
    Rebecca L Carrier; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): In this project, natural matrix-based cell delivery vehicles for retinal progenitor cell (RPC) delivery to the subretinal space will be developed and tested, providing a novel therapeutic strategy for ..
  16. Mesenchymal Stem Cells To Mitigate and Treat Cutaneous Injury Following Radiation
    William H McBride; Fiscal Year: 2010
    ..Furthermore, FMBs are biodegradable and are therefore excellent vehicles for delivering MSCs into incisions in radiation-compromised skin and keeping them viable and proliferating in the ..
  17. Personalized therapeutics for inhibiting breast cancer metastasis
    DEBRA AUGUSTE; Fiscal Year: 2012
    ..My previous work, targeting cytokine-activated endothelial cells, presents compounding evidence that vehicles that complement the cell surface enhance binding...
  18. Development of Novel Inducers of Non-Apoptotic Cell Death to Target Glioblastoma
    William A Maltese; Fiscal Year: 2013
    ..through the identification of the molecular targets of MOMIPP and the development of nanoparticle (NP) delivery vehicles and/or targeted prodrugs that can be used to direct the compound specifically to GBM...
  19. Somatic stem cells in the Drosophila ovary
    DANIEL D KALDERON; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Stem cells are key vehicles for future regenerative therapies and are critical cells for the earliest steps of development of many cancers, ..
  20. Non-viral gene delivery to neural progenitor cells in the SVZ
    Suzie H Pun; Fiscal Year: 2012
    ..If successful, the potential impact of this project is broad. The developed vectors could be used as vehicles to deliver therapeutic genes for treatment of neurogenerative CNS disorders...
  21. Immunotherapeutic HPV cancer vaccines that target Langerhans cells
    Gerard Zurawski; Fiscal Year: 2010
    ..a platform technology for targeting antigens directly to human DC subsets via anti-DC receptor antibody vehicles. Mouse model, human in vitro, and NHP in vivo studies show that vaccines based on DC-targeting elicit potent and ..
  22. Nanocapsule-mediated topical delivery of VLP-generating Dengue DNA vaccine
    Gretchen M Unger; Fiscal Year: 2013
    ..Fourth, in a separate study arm, we will compound the s50 DENV-2 DNA vaccine in a panel of semisolid vehicles (lotions and/or gels) to obtain maximum and uniform dose delivery, and execute a proof-of-principle study in mice ..
  23. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..The specific hypothesis is that nanoparticles conjugated with iron chelators can serve as vehicles not only to send chelators into the brain but also bring the iron (and some other metals)-chelator complexes out ..
  24. EVOLUTION OF PSYCHOPATHOLOGY IN THE POPULATION
    William W Eaton; Fiscal Year: 2013
    ..These data will be enriched by linking Baltimore ECA respondents to records of the Maryland Department of Motor Vehicles and the Maryland Criminal Justice System...
  25. Immune Cell Carriers for the Delivery of Oncolytic Viruses to Metastatic Tumors
    Richard G Vile; Fiscal Year: 2013
    ..by enhancing T cell trafficking, survival and activity using immune conditioning and alternative cell types as vehicles for enhanced T cell trafficking/virus delivery...
  26. Injectable Anabolic Biomaterials for Bone Regeneration
    LAKSHMI SREEDHARAN NAIR; Fiscal Year: 2013
    ..One of our immediate objectives is to design cell delivery vehicles that will transiently act as a favorable microenvironment at the healing site to modulate cell performance upon ..
  27. Viral oncoprotein targeted immune therapy for Merkel cell carcinoma
    Paul Nghiem; Fiscal Year: 2013
    ..determine the baseline and induced expression of viral peptide/HLA complexes on MCC cells and could be readily developed into tumor-targeted delivery vehicles for stimulatory cytokines, radioactivity emitters, or emerging therapeutics.
  28. Creation of adult epithelial stem cells from differentiated epithelial
    Robert A Weinberg; Fiscal Year: 2010
    ..reprogramming of differentiated adult cells into committed progenitors and stem cells, which can then serve as vehicles for the regeneration of adult tissues depleted by aging or by various pathological processes...
  29. Polysaccharide Ecocomposite Materials: Recyclable Synthesis and Applications
    Chieu D Tran; Fiscal Year: 2012
    ..composite materials are superior to CS-based materials currently available for use as sorbents for pollutants, vehicles to deliver drugs and bandages to control, clean and heal hemorrhages ...
  30. Molecularly guided multimodal theranostics for breast cancer
    Amit Joshi; Fiscal Year: 2013
    ..in which agents can be tuned, tailored and targeted into simultaneous therapeutic and diagnostic (theranostic) vehicles for highly specific, personalized medicine. The specific aims of this five-year research program are: 1...
  31. Carboxyl Ester Lipase Affects Hepatic HDL Metabolism
    PHILIP HOWLES; Fiscal Year: 2009
    ..High density lipoproteins (HDL) are the primary vehicles for RCT and transport the cholesterol primarily as cholesteryl esters...
  32. Influenza Therapeutics Using siRNA Nanoparticle Technology
    David M Evans; Fiscal Year: 2010
    ..This proposal seeks to use these vehicles in in vivo infection models to simultaneously deliver multiple siRNAs against key viral targets to increase ..
  33. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENAL TOXICOLOGY PROGRAM
    Reshan Fernando; Fiscal Year: 2010
    ..and dose analysis methods were developed and validated for di-(2-ethylhexyl) phthalate in two different feed vehicles. In support of the carcinogenesis program, a low-level impurity screen was conducted on styrene acrylonitrile ..
  34. Interdisciplinary Training in Virology and Gene Therapy
    Ren Sun; Fiscal Year: 2013
    ..The key issue in gene therapy is the development of delivery vehicles. To fulfill the national need, the UCLA Virology and Gene Therapy Training Program aims to provide a unique and ..
  35. Exosome RNA-Therapeutics to Promote CNS Myelination
    Richard P Kraig; Fiscal Year: 2013
    ..The work is innovative because it uses naturally occurring signaling molecules and vehicles for delivery of EE-like enhancement of myelination...
  36. Targeted Gene Therapy and Nanomedicine Approaches to Treat Corneal Diseases
    RAJIV RAVINDRA MOHAN; Fiscal Year: 2012
    ..hypotheses that GNPs stabilized in gum arabic or polyethyleneimine are nontoxic, non-immunogenic and efficient vehicles for transporting therapeutic genes into keratocytes of the rabbit cornea in vivo, can provide safe and novel ..
  37. WGA as a Novel Vehicle for Intranasal Delivery of an Anti-A-beta Antibody in AD
    Neelima B Chauhan; Fiscal Year: 2012
    This application is in response to PAS-10-151 {Grants for Alzheimer's Disease Drug Discovery (R21)}. Novel vehicles are needed to effectively target direct delivery of immunotherapeutics to the brain in order to maximize the ..
  38. Mouthgard BITES (Behavior, Impulsivity, Theory Evaluation Study)
    DAWN COMSTOCK; Fiscal Year: 2010
    ..plan to expand current research and encourage new studies of craniofacial injuries, including injury prevention programs targeted to the public to promote wearing protective head and face gear in sports and in operating riding vehicles.
  39. Targeted Polymer Micelles for Treatment of Metastatic Melanoma
    Kevin N Sill; Fiscal Year: 2013
    ..In order to accomplish these goals, drug delivery vehicles are needed which are stable to post-administration dilution, can avoid biological barriers (e.g...
  40. Connecticut Veterinary Medical Diagnostic Laboratory
    GUILLERMO ROBERTO RISATTI; Fiscal Year: 2013
    ..molecular based detection of pathogens, including those in environmental samples (animal housing and transport vehicles) and food products (primarily eggs and milk)...
  41. Analysis of Polyhydroxyalkanoate Inclusion Biogenesis
    Douglas Dennis; Fiscal Year: 2009
    ..The purpose of this research is to test this preliminary model in hopes of adapting the strategy of biogenesis for medical applications in which inclusions could be used as drug delivery vehicles.
  42. pH Sensitive Complex Hydrogels for Protein Drug Release
    Nicholas A Peppas; Fiscal Year: 2013
    ..The new systems, henceforth designated as P (MAA-g-EG), have shown extreme promise as oral delivery vehicles for insulin, calcitonin, and growth hormone...
  43. Clathrin-coated vesicles and endocytic function
    Linton M Traub; Fiscal Year: 2013
    ..from the cell surface for delivery to intracellular organelles within small, membrane-encapsulated transport vehicles. Defects in clathrin- mediated endocytosis are linked to several important human disease states, from ..
  44. Novel therapeutic approaches to treatment of botulinum neurotoxin poisoning
    Eric A Johnson; Fiscal Year: 2013
    ..The construction and expression of these atoxic BoNT derivatives provide molecular delivery vehicles that target motor neurons, and can contain specific sites for enzymatic attachment of a wide variety of cargo and ..
  45. Novel Nanoparticle Therapy for Pancreatic Cancer
    Mark Kester; Fiscal Year: 2013
    ..calcium phosphosilicate nanoparticles (NPs) with enhanced tumor uptake and delivery compared to untargeted vehicles. Our research team has developed a means to encapsulate either gene therapy or chemotherapeutic agents in NPs, ..
  46. Safe, Rapid Telomere Extension to Prevent and Treat Hypertension
    Helen M Blau; Fiscal Year: 2013
    ..To optimize i.v. delivery of our drug we will compare the best current and cutting-edge RNA vehicles. In 2007 it was discovered that in the human body, exosomes transport mRNA between cells via body fluids ..
  47. Motor neuron-targeted adenovirus antidotes for botulism
    CHARLES BIX SHOEMAKER; Fiscal Year: 2013
    ..Adenoviruses (Ads) are ideal vehicles for delivery of TFBs to motor neurons for several reasons...
  48. Expanding the Clinical Utility of Ultrasound-Assisted Transdermal Drug Delivery
    ROBERT SAMUEL LANGER; Fiscal Year: 2013
    ..a combination of LFS and the surfactant sodium lauryl sulfate (SLS), as well as to design nano-scale delivery vehicles to be used after LFS/SLS treatment to increase the transdermal delivery of high-molecular weight permeants, such ..
  49. Computational modeling of viral assembly: encapsulation of nucleic acids and env
    Michael F Hagan; Fiscal Year: 2013
    ..therapies that inhibit NA packaging or budding, and would guide efforts to exploit viruses as targeted transport vehicles. Assembly mechanisms inferred from experiments alone are incomplete because intermediates are transient...
  50. Probiotic Yogurt for the Treatment of Minimal Hepatic Encephalopathy
    Jasmohan S Bajaj; Fiscal Year: 2011
    ..of cirrhosis which can result in poor quality of life, impaired cognition and difficulty in driving motor vehicles with a high traffic accident risk. MHE is estimated to affect one half of the 5.5 million cirrhotics in the U.S...
  51. Robotic System with Multiplexed DOF Control for Minimally Invasive Interventions
    Peter Kazanzides; Fiscal Year: 2012
    ..procedures are pervasive in medicine and further, needles and catheters are among the least invasive vehicles for accessing the interior of the human body. They can be used for diagnoses (e.g...
  52. BDNF-engineered stem cell mediated neuroprotection in EAE
    SUHAYL S DHIB JALBUT; Fiscal Year: 2010
    ..In addition, the BMSCs can be utilized as delivery vehicles for therapeutic proteins such as neurotrophic factors and anti-inflammatory cytokines into the CNS...
  53. Biology of Alpha Particle Immunotherapy
    David A Scheinberg; Fiscal Year: 2013
    ..The long- term goals of the project are to develop simple targeting vehicles that kill via alpha particle emission and that make use of our understanding of the tumor's response to ..
  54. Effects of Fine Particle Composition on Birth Outcomes
    Michelle L Bell; Fiscal Year: 2013
    ..5 from specific sources (e.g. motor vehicles)...
  55. Recombinant siRNA Carriers for Targeted Delivery across the Blood Brain Barrier
    DARIN YALE FURGESON; Fiscal Year: 2010
    ..This treatment regimen is far from optimized, necessitating the advance of new siRNA delivery vehicles. More problematic is transport across the blood brain barrier (BBB) to effectively treat neurodegenerative ..
  56. Illuminating the Mechanistic Pathways of Polymer-Mediated Nucleic Acid Delivery
    Theresa M Reineke; Fiscal Year: 2010
    ..goals of this project directly commence from our previous work where we aim to examine our wide-range of delivery vehicles for their mechanistic pathways and kinetics of nucleic acid encapsulation and intracellular transport from the ..
  57. Plasma miRNA Biomarkers of HIV/SIV CNS Disease
    Janice E Clements; Fiscal Year: 2013
    ..will be studied in brain and specific plasma fractions to identify cellular sources of circulating miRNAs and the vehicles (vesicles, lipoprotein particles, protein complexes) of disease-predictive plasma miRNAs (Aim 4)...
  58. MRI Capable Receptor Targeted Drug Delivery for Pancreatic Cancer
    Lily Yang; Fiscal Year: 2013
    ..novel MRI approaches that are designed for specific and sensitive detection of magnetic nanoparticle delivery vehicles in vivo...
  59. Novel multivalent vaccine for anthrax and botulinum
    Mansour Mohamadzadeh; Fiscal Year: 2013
    ..vaccine strategy will be used to show that they are important for multivalent vaccine delivery as well as critical vehicles that stimulate mucosal and systemic immunity for combating deadly bacteria such as anthrax and botulinum.
  60. Endosymbiont, Arbovirus &Mosquito Interactions and the Disease Control
    Zhiyong Xi; Fiscal Year: 2013
    ..The endosymbiotic bacterium, Wolbachia, has long been promoted as potential vehicles for introducing disease- resistant genes into mosquitoes, making them refractory to the pathogens they carry...
  61. Applications of Core-Shell Ti02 Nanoconjugates
    Gayle E Woloschak; Fiscal Year: 2013
    ..funding period, this application was dedicated to the development of TiO2-biopolymer nanoconjugates as new vehicles for biotechnology...
  62. DMRT1 IN MAMMALIAN SEXUAL DEVELOPMENT
    David A Zarkower; Fiscal Year: 2013
    ..The testis has two essential functions: production of sperm, the cells that serve as vehicles for the immortality of male germ line DNA;and production of hormones that direct other parts of the body to ..
  63. Nanoparticle delivery system for antiturberculosis drug
    Leonid Heifets; Fiscal Year: 2004
    ..Research Center of Molecular Diagnostics and Therapy (RDCMDT) in the evaluation of nanoparticles as drug delivery vehicles for anti-tuberculosis drugs...
  64. MUCOSAL IMMUNITY TO HIV ENV BY ORAL VACCINATION
    Danuta Kozbor; Fiscal Year: 2001
    ..We propose to explore the possibility of using poly(DL-lactide-co-glycolide) (PLG) microparticles as vehicles for oral vaccination with plasmid DNA encoding gp160 in combination with recombinant viral vectors expressing the ..
  65. Ultrasound guided site-specific gene delivery in prostate cancer
    Pier Paolo Claudio; Fiscal Year: 2010
    ..Ultrasound contrast agents (microbubbles) may be designed to serve as safe vehicles to encapsulate and deliver genetic materials...
  66. Nanospheres as Delivery Vehicles for Psoriasis Therapeutics
    LARISA contact SHEIHET; Fiscal Year: 2010
    ..Our goal is to study the feasibility of tyrosine-derived nanospheres as delivery vehicles for a wide range of lipophilic drugs into the skin as well as nanospheres interactions with healthy and diseased ..
  67. Improved Peptide-based Tumor Targeting Agents Using Phage Display
    Susan L Deutscher; Fiscal Year: 2010
    ..in antibody-based radiopharmaceutical drug discovery, there remains a critical need to identify new targeting vehicles and biomarkers...
  68. Novel Osteoinductive Protein Synthesizing Implant System
    Kyumin Whang; Fiscal Year: 2003
    ..g. lovastatin, simvastatin). However, their use in bone formation is limited due to a lack of suitable delivery vehicles. The long-range goal of this work is to develop optimized delivery devices for tissue engineering...
  69. Stem cells as vehicles for therapeutic nanoparticle delivery to breast cancer
    Deryl Troyer; Fiscal Year: 2009
    ..Another avenue for increasing the specificity of drug delivery is via stem cells that can serve as delivery vehicles for targeting therapeutic cytokines to tumors...
  70. Stem Cells as Delivery Vehicles and Imaging Probes for Glioma Gene Therapy
    Syed Ali; Fiscal Year: 2009
    ..Moreover, the vehicles for successful delivery of desired gene at desired site is still lacking...
  71. OCULAR CANNABINOID EFFECTS
    Gregory Liou; Fiscal Year: 2001
    ..At least ten vehicles will be tested to identify four that give most trans-corneal drug transfer...
  72. PEPTIDE-PULSED DENDRITIC CELL THERAPY FOR MELANOMA
    Frank Haluska; Fiscal Year: 2000
    ..They appear to be ideal vehicles for delivery of antigen in tumor vaccination strategies...
  73. Shape Specific, Enzyme-Responsive, Nano-Imprinted Particles for Drug Delivery
    Krishnendu Roy; Fiscal Year: 2009
    Nanotechnology is one of the most promising avenues for the development of advanced drug delivery vehicles. Classically, the field has focused on synthesizing nanocarriers based on self assembly or emulsion based concepts...
  74. MINIMIZING BLOOD TO EYE RATIO OF TOPICAL EYE MEDICATIONS
    Vincent Lee; Fiscal Year: 1992
    ..a function of drug properties and composition of the drug vehicle, (3) To evaluate the influence of existing drug vehicles on the balance between ocular and systemic drug absorption; these include aqueous solutions, polymer solutions, ..
  75. HIV vectors for stem cell and intrakine gene delivery
    Richard Sutton; Fiscal Year: 2004
    ..Vectors based upon murine leukemia virus (MLV) have been widely used as gene transfer vehicles. Unfortunately, efficient transduction by MLV requires mitosis...
  76. SIMIAN RETROVIRUSES--NOVEL GENE DELIVERY VECTORS
    CURTIS MACHIDA; Fiscal Year: 1999
    DESCRIPTION (Abstract of the application) Retrovirus vectors have received considerable attention as gene delivery vehicles for potential use in human therapy of single gene disorders...