tablets

Summary

Summary: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)

Top Publications

  1. pmc MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments
    Craig W Hendrix
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    PLoS ONE 8:e55013. 2013
  2. ncbi Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial
    Margarita Iniesta
    Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain
    J Clin Periodontol 39:736-44. 2012
  3. ncbi Use of coffee, caffeinated drinks and caffeine tablets for cognitive enhancement in pupils and students in Germany
    A G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
    Pharmacopsychiatry 44:331-8. 2011
  4. ncbi Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets
    Sanjay Garg
    School of Pharmacy, University of Auckland, 93 Grafton Road, Grafton, Auckland, New Zealand
    Antiviral Res 88:S19-29. 2010
  5. ncbi Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety
    A M D Navaratnam
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Trans R Soc Trop Med Hyg 106:400-7. 2012
  6. pmc Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial
    Kassoum Kayentao
    Malaria Research and Training Center, Faculté de Médecine de Pharmacie et d Odonto Stomatologie, Bamako, Mali
    Malar J 11:364. 2012
  7. ncbi Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs
    Camilla Ricci
    Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK
    Anal Bioanal Chem 389:1525-32. 2007
  8. ncbi Minitablets: new modality to deliver medicines to preschool-aged children
    Sarah A Thomson
    Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London, London, England
    Pediatrics 123:e235-8. 2009
  9. ncbi Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration
    L Maggi
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Eur J Pharm Biopharm 50:389-95. 2000
  10. ncbi Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet
    Stephen R Durham
    Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Guy Scadding Building, Royal Brompton Campus, Dovehouse St, SW3 6LY London, United Kingdom
    J Allergy Clin Immunol 125:131-8.e1-7. 2010

Detail Information

Publications352 found, 100 shown here

  1. pmc MTN-001: randomized pharmacokinetic cross-over study comparing tenofovir vaginal gel and oral tablets in vaginal tissue and other compartments
    Craig W Hendrix
    Department of Medicine, Johns Hopkins University, Baltimore, MD, USA
    PLoS ONE 8:e55013. 2013
    ....
  2. ncbi Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial
    Margarita Iniesta
    Section of Graduate Periodontology, Faculty of Odontology, University Complutense, Madrid, Spain
    J Clin Periodontol 39:736-44. 2012
    ..To investigate the effects of an orally administered probiotic on the oral microbiota...
  3. ncbi Use of coffee, caffeinated drinks and caffeine tablets for cognitive enhancement in pupils and students in Germany
    A G Franke
    Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Mainz, Germany
    Pharmacopsychiatry 44:331-8. 2011
    ..There are only few data about substances, prevalence rates and factors associated with CE. The aim of this study was to assess first data about the use of coffee, caffeinated drinks and caffeine tablets for CE at school and university.
  4. ncbi Advances in development, scale-up and manufacturing of microbicide gels, films, and tablets
    Sanjay Garg
    School of Pharmacy, University of Auckland, 93 Grafton Road, Grafton, Auckland, New Zealand
    Antiviral Res 88:S19-29. 2010
    ..as primary dosage forms such as vaginal gels or in alternative dosage forms such as fast dissolve films and tablets. Recent innovations also include development of combination products of highly active antiviral drugs such as ..
  5. ncbi Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety
    A M D Navaratnam
    Department of Infectious Disease Epidemiology, Imperial College London, London W2 1PG, UK
    Trans R Soc Trop Med Hyg 106:400-7. 2012
    ..with a syrup formulation of PZQ with the aim of assessing its safety and efficacy in comparison with crushed PZQ tablets for the treatment of intestinal schistosomiasis in preschool children...
  6. pmc Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial
    Kassoum Kayentao
    Malaria Research and Training Center, Faculté de Médecine de Pharmacie et d Odonto Stomatologie, Bamako, Mali
    Malar J 11:364. 2012
    ..Children are most vulnerable to malaria. A pyronaridine-artesunate pediatric granule formulation is being developed for the treatment of uncomplicated Plasmodium falciparum malaria...
  7. ncbi Characterization of genuine and fake artesunate anti-malarial tablets using Fourier transform infrared imaging and spatially offset Raman spectroscopy through blister packs
    Camilla Ricci
    Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK
    Anal Bioanal Chem 389:1525-32. 2007
    ..we evaluated a new analytical approach for the characterization and fast screening of fake and genuine artesunate tablets using a combination of Raman spectroscopy, Spatially Offset Raman Spectroscopy (SORS) and Attenuated Total ..
  8. ncbi Minitablets: new modality to deliver medicines to preschool-aged children
    Sarah A Thomson
    Centre for Paediatric Pharmacy Research, School of Pharmacy, University of London, London, England
    Pediatrics 123:e235-8. 2009
    ..The goal was to assess the acceptability and suitability of placebo minitablets for preschool-aged children...
  9. ncbi Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration
    L Maggi
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Eur J Pharm Biopharm 50:389-95. 2000
    ..The microorganisms were formulated in single- and double-layer vaginal tablets. The two layers were characterized by different release properties: one is an effervescent composition that ..
  10. ncbi Long-term clinical efficacy in grass pollen-induced rhinoconjunctivitis after treatment with SQ-standardized grass allergy immunotherapy tablet
    Stephen R Durham
    Section of Allergy and Clinical Immunology, National Heart and Lung Institute, Imperial College and Royal Brompton Hospital, Guy Scadding Building, Royal Brompton Campus, Dovehouse St, SW3 6LY London, United Kingdom
    J Allergy Clin Immunol 125:131-8.e1-7. 2010
    ..Sustained and disease-modifying effects of sublingual immunotherapy have never before been confirmed in a large-scale randomized, double-blind, placebo-controlled trial...
  11. ncbi Zero-order release of aspirin, theophylline and atenolol in water from novel methylcellulose glutarate matrix tablets
    A Khairuzzaman
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, University Plaza, Brooklyn, NY 11201, USA
    Int J Pharm 318:15-21. 2006
    ..Aspirin, theophylline and atenolol tablets were compacted on a Carver press using the wet granulation method...
  12. ncbi Are depot antipsychotics more coercive than tablets? The patient's perspective
    M X Patel
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    J Psychopharmacol 24:1483-9. 2010
    ..Although forced medication is sometimes required, the experience of coercion should be minimised by giving patients a fair say in treatment decisions, regardless of formulation...
  13. pmc The initial pharmaceutical development of an artesunate/amodiaquine oral formulation for the treatment of malaria: a public-private partnership
    Catherine Lacaze
    Ellipse Pharmaceuticals, Pessac, France
    Malar J 10:142. 2011
    ....
  14. ncbi Adherence and persistence of single-pill ARB/CCB combination therapy compared to multiple-pill ARB/CCB regimens
    F Zeng
    MedImpact Healthcare Systems, Inc, San Diego, CA, USA
    Curr Med Res Opin 26:2877-87. 2010
    ..To evaluate the impact of angiotensin receptor blocker (ARBs)/dihydropyridine calcium channel blockers (CCBs) single-pill combination (SPC) on adherence to antihypertensive treatment in comparison to free combination of ARBs and CCBs...
  15. ncbi Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial
    Eun Young Lee
    Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Chongno Gu, Seoul, Republic of Korea
    Clin Ther 28:2052-60. 2006
    This study evaluated the efficacy and tolerability of tramadol 37.5-mg/acetaminophen 325-mg combination tablets (tramadoUAPAP) as add-on therapy in subjects with rheumatoid arthritis (RA) pain that was inadequately controlled by NSAIDs ..
  16. ncbi Assessment of hand-held Raman instrumentation for in situ screening for potentially counterfeit artesunate antimalarial tablets by FT-Raman spectroscopy and direct ionization mass spectrometry
    Camilla Ricci
    Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK
    Anal Chim Acta 623:178-86. 2008
    ..This work illustrates the chemical characterization of genuine and fake artesunate antimalarial tablets by portable Raman spectroscopy and validation by FT-Raman spectroscopy and ambient mass spectrometry...
  17. ncbi Raman mapping of low-content API pharmaceutical formulations. I. Mapping of Alprazolam in Alprazolam/Xanax tablets
    Slobodan Sasic
    Analytical R and D, Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK
    Pharm Res 24:58-65. 2007
    ..of API was carried out to provide information on whether there is any structural difference between the commercial Xanax and Alprazolam tablets (the API content less than 1% w/w in both cases) in the batches with low and good recovery.
  18. ncbi Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers
    Jaymin Shah
    Elan Pharmaceuticals, Inc, San Diego, California, USA
    Clin Ther 28:1308-17. 2006
    ..A multiparticulate capsule formulation of the alpha2-adrenergic agonist tizanidine has been developed to decrease C(max), AUC, and associated somnolence, while maintaining efficacy...
  19. ncbi Mirtazapine orally disintegrating tablets in depressed nursing home residents 85 years of age and older
    J Craig Nelson
    Department of Psychiatry, University of California, San Francisco, USA
    Int J Geriatr Psychiatry 21:898-901. 2006
    ..For these reasons, this study of mirtazapine orally disintegrating tablets was carried out in nursing home residents>or=85 years old with physician-diagnosed depression...
  20. ncbi Caries preventive effect of fluoride in milk, salt and tablets: a literature review
    I Espelid
    Department of Paediatric Dentistry and Behavioural Science Faculty of Dentistry, University of Oslo, Oslo, Norway
    Eur Arch Paediatr Dent 10:149-56. 2009
    There are a number of studies in the literature about the effectiveness of fluoride in tablets, fluoride added to frequently-consumed food like milk, or to food additives like salt, in prevention of dental caries...
  21. ncbi Drug characterization in low dosage pharmaceutical tablets using Raman microscopic mapping
    Mark J Henson
    Pfizer Analytical R and D, Groton, Connecticut 06340, USA
    Appl Spectrosc 60:1247-55. 2006
    Raman micro-spectroscopic mapping is utilized to analyze pharmaceutical tablets containing a low concentration (0.5% w/w) of active pharmaceutical ingredient (API)...
  22. ncbi Release of naltrexone on buccal mucosa: permeation studies, histological aspects and matrix system design
    Libero Italo Giannola
    Dipartimento di Chimica e Tecnologie Farmaceutiche, Universita di Palermo, Palermo, Italy
    Eur J Pharm Biopharm 67:425-33. 2007
    ..b>Tablets, designed for Naltrexone hydrochloride (NLX) administration on buccal mucosa, were developed and prepared by ..
  23. ncbi Swelling kinetics of spray-dried chitosan acetate assessed by magnetic resonance imaging and their relation to drug release kinetics of chitosan matrix tablets
    Kampanart Huanbutta
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
    Eur J Pharm Biopharm 77:320-6. 2011
    ..1N HCl, pH 6.8 and pH 5.0 Tris-HCl buffers. The in vitro drug releases from CSA matrix tablets containing the model drugs, diclofenac sodium and theophylline were investigated in all media using USP-4 ..
  24. ncbi Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets
    Camilla Ricci
    Department of Chemical Engineering, Imperial College London, London, SW7 2AZ, UK
    Anal Bioanal Chem 387:551-9. 2007
    ..ionization linear ion-trap mass spectrometry (DESI MS) for characterization of counterfeit pharmaceutical tablets. The counterfeit artesunate antimalarial tablets were analyzed by both techniques...
  25. ncbi Glipizide controlled-release tablets, with or without acarbose, improve glycaemic variability in newly diagnosed Type 2 diabetes
    Yu Qian Bao
    Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes Shanghai Jiao Tong University Affiliated Sixth People s Hospital Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China
    Clin Exp Pharmacol Physiol 37:564-8. 2010
    1. The aim of the present study was to compare the effects of glipizide controlled-release (CR) tablets monotherapy with that of glipizide CR tablets plus acarbose on glycaemic variability in newly diagnosed Type 2 diabetes (T2DM) ..
  26. ncbi Olanzapine orally disintegrating tablets in the treatment of acutely ill non-compliant patients with schizophrenia
    Bruce J Kinon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Int J Neuropsychopharmacol 6:97-102. 2003
    ..disorder who met medication non-compliance criteria received open-label olanzapine orally disintegrating tablets (1020 mgd) for up to 6 wk...
  27. ncbi Favorable acceptance of mini-tablets compared with syrup: a randomized controlled trial in infants and preschool children
    Viviane Klingmann
    Department of General Pediatrics, Neonatology, and Pediatric Cardiology, University Children s Hospital Düsseldorf, Dusseldorf, Germany
    J Pediatr 163:1728-1732.e1. 2013
    To evaluate acceptability of 2 mm solid dosage forms (mini-tablets) as an alternative administration modality in young children in comparison with syrup.
  28. ncbi Ranitidine (Zantac) syrup versus Ranitidine effervescent tablets (Zantac) EFFERdose) in children: a single-center taste preference study
    Vanessa Z Ameen
    Clinical Pharmacology and Discovery Medicine, Research and Development, GlaxoSmithKline, Research Triangle Park, North Carolina 27709, USA
    Paediatr Drugs 8:265-70. 2006
    ..Ranitidine syrup is available in a peppermint-flavored 15 mg/mL formulation...
  29. ncbi Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets
    Maria Rotchés-Ribalta
    Nutrition and Food Science Department, XaRTA INSA, Pharmacy Faculty, University of Barcelona, Av Joan XXIII, S N, Barcelona, Spain
    Pharmacol Res 66:375-82. 2012
    ..matrix and, therefore, this study has been compared with a pilot study in which men ingested grape extract (GE) tablets as a nutraceutical, containing similar total amounts of resveratrol than RW...
  30. ncbi Ciprofloxacin prolonged-release tablets do not affect warfarin pharmacokinetics and pharmacodynamics
    Carla Washington
    Depomed Inc, Menlo Park, CA 94025, USA
    J Clin Pharmacol 47:1320-6. 2007
    ..029). This difference is not considered clinically relevant, because the values remain similar. These results show that warfarin pharmacokinetics and pharmacodynamics are not altered with concomitant administration of ciprofloxacin PR...
  31. ncbi Bioequivalence of methylphenidate immediate-release tablets using a replicated study design to characterize intrasubject variability
    M C Meyer
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee, Memphis 38163, USA
    Pharm Res 17:381-4. 2000
    To determine the relative bioavailability of two marketed, immediate-release methylphenidate tablets. The study used a replicated study design to characterize intrasubject variability, and determine bioequivalence using both average and ..
  32. ncbi Application of face centred central composite design to optimise compression force and tablet diameter for the formulation of mechanically strong and fast disintegrating orodispersible tablets
    Ritesh M Pabari
    School of Pharmacy, Royal College of Surgeons in Ireland, 123, St Stephens Green, Dublin 2, Ireland
    Int J Pharm 430:18-25. 2012
    ..and compression force (CF) on hardness, disintegration time (DT) and porosity of mannitol based orodispersible tablets (ODTs). Tablet diameters of 10, 13 and 15 mm, and CF of 10, 15 and 20 kN were studied...
  33. pmc Young HIV-infected children and their adult caregivers prefer tablets to syrup antiretroviral medications in Africa
    Patricia Nahirya-Ntege
    MRC UVRI Uganda Research Unit on AIDS, Entebbe, Uganda
    PLoS ONE 7:e36186. 2012
    ..therapy (ART) for HIV-infected children is complicated using syrup formulations, which are costlier than tablets, harder to transport and store and difficult for health-workers to prescribe and caregivers to administer...
  34. ncbi Development of fixed dose combination tablets containing zidovudine and lamivudine for paediatric applications
    E Kayitare
    Department of Pharmacy, National University of Rwanda, Butare, Rwanda
    Int J Pharm 370:41-6. 2009
    ..Rectangular tablets with multiple fraction bars were designed and each tablet can be broken into 8 subunits, each subunit containing ..
  35. ncbi Improving treatment adherence to antihypertensive therapy: the role of single-pill combinations
    Sripal Bangalore
    New York University School of Medicine, The Leon H Charney Division of Cardiology, Cardiac Catheterization Laboratory, NY 10016, USA
    Expert Opin Pharmacother 13:345-55. 2012
    ..Studies have consistently shown that polypharmacy and complex treatment regimens have a detrimental effect on treatment compliance, adherence and persistence (herein referred to as treatment adherence)...
  36. ncbi Novel platforms for oral drug delivery
    P Colombo
    Dipartimento Farmaceutico, Universita degli Studi di Parma, Viale G P Usberti 27 A, 43100, Parma, Italy
    Pharm Res 26:601-11. 2009
    ....
  37. ncbi Design and evaluation of floating multi-layer coated tablets based on gas formation
    Srisagul Sungthongjeen
    Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok, Thailand
    Eur J Pharm Biopharm 69:255-63. 2008
    Floating multi-layer coated tablets were designed based on gas formation...
  38. ncbi Analysis of drug content and weight uniformity for half-tablets of 6 commonly split medications
    Shaynan W Hill
    Department of Pharmacy, Long Beach Veterans Affairs Hospital, Long Beach, CA 90822, USA
    J Manag Care Pharm 15:253-61. 2009
    ..Previous research has shown weight nonuniformity within tablet halves. However, limited research to date has found that the potential dose inaccuracy resulting from splitting tablets does not significantly affect clinical outcomes.
  39. ncbi Development and evaluation of gastroretentive norfloxacin floating tablets
    Ramesh Bomma
    University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009 A P, India
    Acta Pharm 59:211-21. 2009
    Floating matrix tablets of norfloxacin were developed to prolong gastric residence time, leading to an increase in drug bioavailability...
  40. ncbi Sustained 3-year efficacy of pre- and coseasonal 5-grass-pollen sublingual immunotherapy tablets in patients with grass pollen-induced rhinoconjunctivitis
    Alain Didier
    Rangueil Larrey Hospital, Respiratory Diseases Department, Toulouse, France
    J Allergy Clin Immunol 128:559-66. 2011
    ..Seasonal allergic rhinoconjunctivitis affects millions of persons. The efficacy of allergen sublingual immunotherapy (SLIT) was demonstrated in previous short-term studies...
  41. ncbi A novel system for three-pulse drug release based on "tablets in capsule" device
    Bin Li
    Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 210038, PR China
    Int J Pharm 352:159-64. 2008
    ..delivery from a novel system, which contains a water-soluble cap, impermeable capsule body, and two multi-layered tablets. Types of materials for the modulating barrier and its weight can significantly affect the lag time (defined as ..
  42. ncbi Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
    Yonghai Lv
    Department of Medicinal Chemistry of Nature Product, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    J Pharm Biomed Anal 52:129-35. 2010
    Myocardial ischemia (MI) is a worldwide epidemic. Compound Danshen Tablets (CDTs), an herbal compound preparation, are widely used to treat MI in China...
  43. ncbi Acceptance of uncoated mini-tablets in young children: results from a prospective exploratory cross-over study
    Natalie Spomer
    Department of General Paediatrics and Neonatology, University Children s Hospital, Dusseldorf, Germany
    Arch Dis Child 97:283-6. 2012
    To explore the acceptance of uncoated drug-free mini-tablets 2 mm in diameter in children aged 0.5-6 years and their ability to swallow the mini-tablets.
  44. ncbi In-vitro/in-vivo correlation of pulsatile drug release from press-coated tablet formulations: a pharmacoscintigraphic study in the beagle dog
    Manish Ghimire
    University of Strathclyde, Strathclyde Institute of Pharmacy and Biomedical Sciences, Glasgow, United Kingdom
    Eur J Pharm Biopharm 67:515-23. 2007
    ..However, following disintegration, no difference in pharmacokinetic parameters (AUC(0-6 dis), K(el), Cmax) was observed. The current study highlighted the potential use of these formulations for chronopharmaceutical drug delivery...
  45. ncbi Advantages of celecoxib nanosuspension formulation and transformation into tablets
    Andrej Dolenc
    University of Ljubljana, Faculty of Pharmacy, Ljubljana, Slovenia
    Int J Pharm 376:204-12. 2009
    ..Spray-dried nanosuspension was blended with microcrystalline cellulose, and compressed to tablets, and their tensile strength, porosity and elastic recovery of tablets were investigated...
  46. ncbi Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study
    Igor A Sobenin
    Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
    J Atheroscler Thromb 15:334-8. 2008
    ..The study was undertaken to test the hypothesis that garlic powder tablets with a prolonged mode of action promise potent biological effects.
  47. pmc Pharmacokinetics of lopinavir in HIV-infected adults receiving rifampin with adjusted doses of lopinavir-ritonavir tablets
    Eric H Decloedt
    Division of Clinical Pharmacology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa
    Antimicrob Agents Chemother 55:3195-200. 2011
    ..Doubling the dose of the tablet formulation of LPV/r overcomes induction by rifampin. Less hepatotoxicity occurred in our cohort of HIV-infected participants than was reported in healthy-volunteer studies...
  48. ncbi Pharmacokinetics of gabapentin after a single day and at steady state following the administration of gastric-retentive- extended-release and immediate-release tablets: a randomized, open-label, multiple-dose, three-way crossover, exploratory study in hea
    Toufigh Gordi
    Depomed, Inc, 1360 O Brien Drive, Menlo Park, CA 94025, USA
    Clin Ther 30:909-16. 2008
    ..Therefore, conventional sustained formulations would likely result in decreased bioavailability, as the dosage form would pass through the window of absorption before the drug could be completely released...
  49. ncbi Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation
    Rania H Fahmy
    Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Cairo, Egypt
    Eur J Pharm Biopharm 69:993-1003. 2008
    ..into liquisolid systems and then to investigate the in vitro and in vivo performance of the prepared liquisolid tablets. The new mathematical model was utilized to formulate various liquisolid powder systems...
  50. ncbi Formation and identification of a degradant in chlorproguanil-dapsone-artesunate (Dacart™) tablets
    Ben Bardsley
    GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, United Kingdom
    J Pharm Biomed Anal 54:610-3. 2011
    ..These risks are particularly pertinent to products of this type given the climatic conditions which prevail in countries where such therapies are likely to be employed...
  51. ncbi Determination of the in vitro disintegration profile of rapidly disintegrating tablets and correlation with oral disintegration
    G Abdelbary
    Laboratoire de Pharmacie Galénique Industrielle et Cosmétologie, Faculté de Pharmacie de Marseille, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France
    Int J Pharm 292:29-41. 2005
    The assessment of the in vitro disintegration profile of rapidly disintegrating tablets (RDT) is very important in the evaluation and the development of new formulations of this type...
  52. ncbi Liquisolid technique for dissolution rate enhancement of a high dose water-insoluble drug (carbamazepine)
    Yousef Javadzadeh
    Department of Pharmaceutics, Faculty of Pharmacy, Tabriz University of Medical Sciences, Iran
    Int J Pharm 341:26-34. 2007
    ..The results showed that the dissolution rate of liquisolid tablets was not significantly affected by storing the tablets at 25 degrees C/75% relative humidity for a period of 6 ..
  53. ncbi Bowel function during pain therapy with oxycodone/naloxone prolonged-release tablets in patients with advanced cancer
    K E Clemens
    Department of Science and Research, Centre for Palliative Medicine, University of Bonn, Bonn, Germany
    Int J Clin Pract 65:472-8. 2011
    ..The aim of the study was to evaluate whether patients with advanced cancer and moderate to severe cancer pain will benefit from treatment with oxycodone/naloxone prolonged-release tablets (OXN), with particular regard to constipation.
  54. ncbi Effects of liquisolid formulations on dissolution of naproxen
    Ngiik Tiong
    Department of Pharmacy, Health and Well Being, University of Sunderland, Sunderland, United Kingdom
    Eur J Pharm Biopharm 73:373-84. 2009
    ..e. type of non-volatile liquid vehicles and drug concentrations, on drug dissolution rates. The liquisolid tablets were formulated with three different liquid vehicles, namely Cremophor EL (polyoxyl 35 castor oil), Synperonic PE/..
  55. ncbi Strongly enhanced dissolution rate of fenofibrate solid dispersion tablets by incorporation of superdisintegrants
    P Srinarong
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, Groningen, The Netherlands
    Eur J Pharm Biopharm 73:154-61. 2009
    In this study, it was shown that the incorporation of superdisintegrants in solid dispersion tablets containing a high drug load can strongly enhance the dissolution rate of the highly lipophilic drug fenofibrate...
  56. ncbi Effects of disintegration-promoting agent, lubricants and moisture treatment on optimized fast disintegrating tablets
    Sameer G Late
    Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, United States
    Int J Pharm 365:4-11. 2009
    ..Hardness was not affected at 75% moisture treatment. Moisture treatment at 85 and 95% increased hardness of the tablets; however at the same time it negatively affected the disintegration time.
  57. ncbi Swelling, erosion and drug release characteristics of salbutamol sulfate from hydroxypropyl methylcellulose-based matrix tablets
    Faith A Chaibva
    Faculty of Pharmacy, Rhodes University, Grahamstown, South Africa
    Drug Dev Ind Pharm 36:1497-510. 2010
    ..Hydrophilic matrix formulations are important and simple technologies that are used to manufacture sustained release dosage forms...
  58. ncbi Quantitative and qualitative determination of Liuwei Dihuang tablets by HPLC-UV-MS-MS
    Xinfeng Zhao
    Medical College, Dalian University, Dalian 116622, People s Republic of China
    J Chromatogr Sci 45:549-52. 2007
    ..gallic acid, dihydromelittoside, loganin, paeoniflorin, benzoylpaeoniflorin, and paeonol in Liuwei Dihuang tablets by high-performance liquid chromatography (HPLC)-UV-mass spectrometry (MS)-MS...
  59. ncbi A novel 12-week study, with three randomized, double-blind placebo-controlled periods to evaluate fentanyl buccal tablets for the relief of breakthrough pain in opioid-tolerant patients with noncancer-related chronic pain
    John T Farrar
    Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Pain Med 11:1313-27. 2010
    ..To evaluate the time of onset, overall efficacy, and safety of fentanyl buccal tablet (FBT) for noncancer-related breakthrough pain (BTP) in opioid-tolerant adults over 12 weeks...
  60. ncbi Randomized trial of pimecrolimus cream plus colchicine tablets versus colchicine tablets in the treatment of genital ulcers in Behçet's disease
    Osman Kose
    Department of Dermatology, Gulhane School of Medicine, Ankara, Turkey
    Dermatology 218:140-5. 2009
    ..Recurrent and painful genital ulcers are the hallmark of Behçet's disease...
  61. ncbi Safety and tolerability of grass pollen tablets in sublingual immunotherapy--a phase-1 study
    T H Larsen
    Allergy Clinic, National University Hospital, Copenhagen, Denmark
    Allergy 61:1173-6. 2006
    ..A single-centre, randomized, double-blind, placebo-controlled study. Aims: To compare the safety and tolerability of four different sublingual immunotherapy (SLIT) regimes in grass pollen allergic rhinitis...
  62. ncbi First derivative synchronous fluorescence spectroscopy for the simultaneous determination of sulpiride and mebeverine hydrochloride in their combined tablets and application to real human plasma
    M Walash
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516, Mansoura, Egypt
    J Fluoresc 20:1275-85. 2010
    ..was successfully applied for the determination of the two compounds in synthetic mixtures and in commercial tablets. The high sensitivity attained by the proposed method allowed the determination of both of SUL and MEB metabolite ..
  63. ncbi Pharmaceutical applications of confocal laser scanning microscopy: the physical characterisation of pharmaceutical systems
    Samuel R Pygall
    Formulation Insights, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, United Kingdom
    Adv Drug Deliv Rev 59:1434-52. 2007
    ..range of pharmaceutical systems, including phase-separated polymers, colloidal systems, microspheres, pellets, tablets, film coatings, hydrophilic matrices, and chromatographic stationary phases...
  64. ncbi Comparison of intramuscular olanzapine, orally disintegrating olanzapine tablets, oral risperidone solution, and intramuscular haloperidol in the management of acute agitation in an acute care psychiatric ward in Taiwan
    Wen Yu Hsu
    Department of Psychiatry, Lu Tung Branch of Changhua ChristianHospital, Lukang, Taiwan
    J Clin Psychopharmacol 30:230-4. 2010
    ..efficacy and safety among intramuscular olanzapine, intramuscular haloperidol, orally disintegrating olanzapine tablets, and oral risperidone solution for agitated patients with psychosis during the first 24 hours of treatment in an ..
  65. ncbi In vitro-in vivo correlation for wet-milled tablet of poorly water-soluble cilostazol
    Jun ichi Jinno
    Otsuka Pharmaceutical Co, Ltd, 224 18 Ebisuno Hiraishi Kawauchi cho, Tokushima 771 0182, Japan
    J Control Release 130:29-37. 2008
    ....
  66. ncbi High incidence of adverse events in healthy volunteers receiving rifampicin and adjusted doses of lopinavir/ritonavir tablets
    Hanneke M J Nijland
    Department of Clinical Pharmacy, Radboud University Nijmegen Medical Centre, The Netherlands
    AIDS 22:931-5. 2008
    ..Our objective was to study the combined use of rifampicin and the newly introduced lopinavir/ritonavir tablets.
  67. ncbi Efficacy and safety of sublingual immunotherapy with grass allergen tablets for seasonal allergic rhinoconjunctivitis
    Ronald Dahl
    Department of Respiratory Diseases, Aarhus University Hospital, Aarhus, Denmark
    J Allergy Clin Immunol 118:434-40. 2006
    ..The sublingual route also has potential, although definitive evidence from large randomized controlled trials has been lacking...
  68. ncbi Soy isoflavone tablets reduce osteoporosis risk factors and obesity in middle-aged Japanese women
    Mari Mori
    Resarch Institute for Production Development, Mukogawa Women s University, Japan
    Clin Exp Pharmacol Physiol 31:S39-41. 2004
    ..pre- and postmenopausal women were randomly assigned to the following two groups taking either ISO (100 mg) tablets (ISO group) or placebo tablets (P group) containing vitamins C (25 mg) and E (5 mg) daily for 24 weeks in a ..
  69. ncbi Evaluation of rapidly disintegrating tablets containing glycine and carboxymethylcellulose
    Jinichi Fukami
    Kyoto Pharmaceutical Industries Ltd, 38 Nishinokyo, Kyoto 604 8444, Japan
    Int J Pharm 310:101-9. 2006
    ..It was suggested that the tablet formulation containing NS-300 and glycine was highly applicable to water-insoluble drug, such as ethenzamide...
  70. ncbi Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets
    Anna Viridén
    Department of Chemical and Biological Engineering, Chalmers University of Technology, SE 412 96 Gothenburg, Sweden
    Eur J Pharm Sci 36:297-309. 2009
    ..characterized to investigate properties related to critical functionality for their use in hydrophilic matrix tablets. In this study, the HPMC batches were chemically characterized and correlated to the behaviour of pure HPMC ..
  71. ncbi LC-MS determination and relative bioavailability of doxazosin mesylate tablets in healthy Chinese male volunteers
    Ning Ma
    State Key Laboratory, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, PR China
    J Pharm Biomed Anal 43:1049-56. 2007
    This study aims to develop a standard protocol for the relative bioavailability testing of doxazosin mesylate tablets. For this purpose, a simple rapid and selective LC-MS method using a single quadrupole mass spectrometer was developed ..
  72. ncbi Fixed artesunate-amodiaquine combined pre-formulation study for the treatment of malaria
    Tina Kauss
    Laboratory of Galenic Pharmacy and Biopharmacy, Bordeaux 2 University, France
    Int J Pharm 395:198-204. 2010
    ..AS and AQ incompatibility led to AS degradation and pharmaco-technical changes in classical wet granulation tablets. Both active principles are stable as dry powders...
  73. ncbi Sustained delivery of captopril from floating matrix tablets
    Inéz Jiménez-Martínez
    Department of Biological Systems, Autonomous Metropolitan University Xochimilco, Calzada del Hueso 1100, Col Villa Quietud, C P 04960, D F, Mexico
    Int J Pharm 362:37-43. 2008
    ..In this work, the in vitro sustained release of captopril from Metolose SH 4000 SR/sodium bicarbonate floating tablets has been studied, varying the proportions of Metolose and bicarbonate...
  74. ncbi Design and evaluation of bilayer floating tablets of captopril
    Ziyaur Rahman
    Department of Pharmaceutics, Faculty of Pharmacy Hamdard University, New Delhi 110062, India
    Acta Pharm 56:49-57. 2006
    ..Placebo formulation containing barium sulphate in the release layer administered to human volunteers for in vivo X-ray studies showed that BFT had significantly increased the gastric residence time...
  75. ncbi Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study
    Igor A Sobenin
    Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia
    Acta Diabetol 45:1-6. 2008
    ..The results of this study may allow recommending garlic powder tablets Allicor for the treatment of type 2 diabetes mellitus along with dietary treatment and/or sulfonylurea ..
  76. ncbi Evaluation of speed and duration of efficacy of spinosad tablets for treatment and control of Ctenocephalides canis (Siphonaptera: Pulicidae) infestations in dogs
    M Franc
    UMR 181, Ecole Nationale Veterinaire de Toulouse, 23, Chemin des Capelles, 31076 Toulouse Cedex France
    Parasite 16:125-8. 2009
    ..Twelve Beagle dogs (two groups of six) were used in the study. Dogs in the treated group received spinosad tablets per os on D0 at the commercial dosage...
  77. pmc Medicines informal market in Congo, Burundi and Angola: counterfeit and sub-standard antimalarials
    Maria Cristina Gaudiano
    Dipartimento del Farmaco, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Malar J 6:22. 2007
    ..The increase of the phenomenon of pharmaceutical counterfeiting is due to the rise of the illegal market and to the impossibility to purchase branded high cost medicines...
  78. ncbi Human osteoblasts adhesion and proliferation on magnesium-substituted tricalcium phosphate dense tablets
    Marcia S Sader
    Metallurgical and Materials Department, COPPE UFRJ, Rio de Janeiro, RJ, Brazil
    J Mater Sci Mater Med 20:521-7. 2009
    ..Mg-substituted TCP (beta-TCMP) and beta-TCP dense tablets were obtained by pressing and sintering at 1,000 degrees C Mg-substituted calcium deficient apatite (Mg-CDA) and ..
  79. ncbi Safety of chewable tablets for children
    Theresa M Michele
    Merck Research Laboratories, Rahway, New Jersey 07065, USA
    J Asthma 39:391-403. 2002
    ..Chewable tablets are a widely used pediatric dosage form; however, a literature review on the safety of this formulation has not ..
  80. ncbi Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC
    M Harris Shoaib
    Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, Karachi 75270, Pakistan
    Pak J Pharm Sci 19:119-24. 2006
    ..In order to achieve required sustained release profile tablets were directly compressed using Avicel pH 101 and Magnesium stearate...
  81. ncbi Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets
    S Takka
    Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA
    Eur J Pharm Biopharm 52:75-82. 2001
    ..The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer.
  82. ncbi In-vitro studies of diclofenac sodium controlled-release from biopolymeric hydrophilic matrices
    Silvina A Bravo
    Department of Pharmacy, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Argentina
    J Pharm Pharm Sci 5:213-9. 2002
    The objective of this study was to develop uncoated HPMC matrix tablets, evaluating the relationship and influence of different content levels of microcrystalline cellulose (MCC), starch, and lactose, in order to achieve a zero-order ..
  83. ncbi Breaking of scored tablets: a review
    E van Santen
    National Institute of Public Health and the Environment, Bilthoven, The Netherlands
    Eur J Pharm Biopharm 53:139-45. 2002
    The literature was reviewed regarding advantages, problems and performance indicators of score lines. Scored tablets provide dose flexibility, ease of swallowing and may reduce the costs of medication...
  84. ncbi Are 1-2 tablets dangerous? Beta-blocker exposure in toddlers
    Jeffrey N Love
    Department of Emergency Medicine, Georgetown University Hospital, Washington, DC 20057, USA
    J Emerg Med 26:309-14. 2004
    ..are no clear guidelines in the literature to direct the care of the toddler with the history of ingesting 1-2 tablets. With 40 years of extensive clinical experience, not one documented case of death or serious cardiovascular ..
  85. ncbi High-performance liquid chromatographic method for the bioequivalence evaluation of desloratadine fumarate tablets in dogs
    Lihe Liu
    School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China
    J Pharm Biomed Anal 34:1013-9. 2004
    ..of desloratadine in dog plasma and was used for evaluating the bioequivalence of desloratadine fumarate tablets and desloratadine tablets in dogs. Chromatographic separation was performed on a Hypersil CN column (150 mm x 5...
  86. ncbi Formulation and evaluation of mucoadhesive tablets containing eugenol for the treatment of periodontal diseases
    Bhimrao K Jadhav
    Department of Pharmacognosy, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Erandwane, Pune, Maharashtra State, India
    Drug Dev Ind Pharm 30:195-203. 2004
    ..This study reports the development and evaluation of controlled-release mucoadhesive tablets for gingival application, containing eugenol, which are prepared by taking carbopol 934 P and Hydroxypropyl ..
  87. ncbi Tramadol/acetaminophen combination tablets for the treatment of pain associated with osteoarthritis flare in an elderly patient population
    Norman R Rosenthal
    Ortho McNeil Pharmaceutical, Raritan, New Jersey 08869, USA
    J Am Geriatr Soc 52:374-80. 2004
    To evaluate the efficacy and safety of adding tramadol 37.5 mg/acetaminophen (APAP) 325 mg combination tablets (tramadol/APAP) to existing therapy for painful osteoarthritis (OA) flare in a subset of elderly patients.
  88. ncbi Patients' preference for administration of endocrine treatments by injection or tablets: results from a study of women with breast cancer
    L Fallowfield
    Sussex Psychosocial Oncology Group, Cancer Research UK, Brighton and Sussex Medical School, University of Sussex, Sussex, UK
    Ann Oncol 17:205-10. 2006
    Endocrine therapies for advanced breast cancer include tablets and intramuscular injections. When treatments have similar efficacy and tolerability profiles, addressing preferences about routes of administration is important.
  89. ncbi [Use of probiotics Bifidumbacterin and Acilact in tablets in therapy of periodontal inflammations]
    A I Grudianov
    Stomatologiia (Mosk) 81:39-43. 2002
    ..The effect of Acilact and Bifidumbacterin to the normalisation of Mycroflora higher in comparison with Tantum-Verde, particulary in the cases of gingivitis and parodontitis superficialis...
  90. ncbi Optimization of a self-nanoemulsified tablet dosage form of Ubiquinone using response surface methodology: effect of formulation ingredients
    S Nazzal
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Technical University Health Science Center, Amarillo, TX 79106, USA
    Int J Pharm 240:103-14. 2002
    ..6, 560.1 and 100, respectively. A new formulation was prepared according to these levels. The observed responses were in close agreement with the predicted values of the optimized formulation...
  91. pmc Higher strength lanthanum carbonate provides serum phosphorus control with a low tablet burden and is preferred by patients and physicians: a multicenter study
    Rajnish Mehrotra
    Division of Nephrology and Hypertension, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Clin J Am Soc Nephrol 3:1437-45. 2008
    ..This phase IIIb trial assessed the efficacy of increased dosages (3000 to 4500 mg/d) of reformulated lanthanum carbonate (500-, 750-, and 1000-mg tablets) in nonresponders to dosages of up to 3000 mg/d.
  92. ncbi A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansing
    John F Johanson
    Rockford Gastroenterology Associates, Rockford, Illinois, USA
    Am J Gastroenterol 102:2238-46. 2007
    The safety and efficacy of NaP tablets have not been compared with 2L PEG lavage solution...
  93. ncbi Combining two-dimensional diffusion-ordered nuclear magnetic resonance spectroscopy, imaging desorption electrospray ionization mass spectrometry, and direct analysis in real-time mass spectrometry for the integral investigation of counterfeit pharmaceuti
    Leonard Nyadong
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Anal Chem 81:4803-12. 2009
    ..Fourteen different artesunate tablets, representative of what can be purchased from informal sources in southeast Asia, were investigated with these ..
  94. pmc A randomized, crossover design study of sevelamer carbonate powder and sevelamer hydrochloride tablets in chronic kidney disease patients on haemodialysis
    Stanley Fan
    Department of Nephrology, Royal London Hospital, London, UK
    Nephrol Dial Transplant 24:3794-9. 2009
    ..This study compared the safety and efficacy of sevelamer carbonate powder with sevelamer hydrochloride tablets in CKD patients on haemodialysis.
  95. ncbi Efficacy and safety of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 52-week open-label studies
    Robin Emsley
    Department of Psychiatry, University of Stellenbosch, Tygerberg, Cape Town, South Africa
    Int Clin Psychopharmacol 23:343-56. 2008
    Long-term efficacy and safety of paliperidone extended-release tablets (3-12 mg/day) were evaluated in pooled data from 52-week open-label extension (OLE) phases of three 6-week, placebo-controlled, double-blind (DB) trials involving ..
  96. ncbi Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents
    Michael Blaiss
    Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tenn, USA
    J Allergy Clin Immunol 127:64-71, 71.e1-4. 2011
    ..Allergy immunotherapy tablet (AIT) treatment might be a safe and convenient form of specific immunotherapy but it has not been investigated in North American children and adolescents...
  97. ncbi In vitro disintegration and dissolution studies of once-weekly copies of alendronate sodium tablets (70 mg) and in vivo implications
    Richard J Dansereau
    Procter and Gamble Pharmaceuticals, Inc, Mason, OH 45040 9462, USA
    Curr Med Res Opin 24:1137-45. 2008
    The aim of this study was to evaluate the in vitro disintegration and dissolution of 26 alendronic acid tablets (70 mg) on the market in Canada, Germany, the Netherlands, and the United Kingdom compared to the branded product (Fosamax).
  98. ncbi Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers
    Mohammad Hadi Modaghegh
    Mashhad Vascular Surgery Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad MUMS, Islamic Republic of Iran
    Phytomedicine 15:1032-7. 2008
    Saffron (Crocus sativus) stigma tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. The study was a double-blind, placebo-controlled design consisting of a 1 week treatment of saffron tablets...
  99. ncbi Taste masking microspheres for orally disintegrating tablets
    Jianchen Xu
    The College of Pharmaceuticals and Biotechnology, Tianjin University, Tianjin, PR China
    Int J Pharm 359:63-9. 2008
    ..was to evaluate the potential of microspheres for taste masking when incorporated into orally disintegrating tablets. The microspheres were produced by spray drying a mixture of the model compound (famotidine) with taste masking ..
  100. ncbi Pharmacokinetics of dihydroartemisinin in Artekin tablets for single and repeated dosing in Chinese healthy volunteers
    Xin Hong
    Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, PR China
    Biopharm Drug Dispos 29:237-44. 2008
    Aim. To study the pharmacokinetics of dihydroartemisinin (DHA) in Artekin (compound dihydroartemisinin) tablets in Chinese healthy volunteers. Methods...
  101. ncbi In vitro and in vivo evaluation of nimesulide lyophilized orally disintegrating tablets
    Raguia Ali Shoukri
    Department of Pharmaceutics and Industrial Pharmacy, Cairo University, Cairo, Egypt
    Eur J Pharm Biopharm 73:162-71. 2009
    ..012) peak plasma concentration, and shortened time to C(max) by 1h (p=0.029). The extent of absorption expressed by AUC was 62% larger when compared to the commercially available tablet...

Research Grants63

  1. Bupropion VS Placebo to Treat Pathological Gambling
    Donald Black; Fiscal Year: 2004
    ..Subjects on placebo will be administered a similar number o tablets. Subjects will be seen at weeks 1, 2, 4, 6, 8, 10, and 12...
  2. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2013
    ..Each visit will take about 2 to 4 hours. - Participants will take minocycline tablets twice daily for 24 months...
  3. STATISITICAL DESIGN, MONITORING &COORD. OF VISION CLINICAL TRIALS &EPIDEMIOLOGY
    Keri Hammel; Fiscal Year: 2012
    ..Each visit will take about 2 to 4 hours. - Participants will take minocycline tablets twice daily for 24 months...
  4. Programming of Protective CD8 T-Cell Memory by Live and Adjuvanted Subunit Vaccin
    Marulasiddappa Suresh; Fiscal Year: 2013
    ..of acrylic acid) have been used in the pharmaceutical industry to achieve controlled release of medications in tablets and as a bioadhesive in mucosal applications...
  5. Wireless and Noise Attenuating Headset for Automated Hearing Screening
    Odile H Clavier; Fiscal Year: 2013
    ..the proposed device will enhance the development of quality audiology applications for use with smartphones, tablets, and the Internet...
  6. Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
    Charles C Y Shih; Fiscal Year: 2013
    ..g., capsules, tablets, syrup) will be developed...
  7. Development of Age-Appropriate Fast Disintegrating Pediatric Granules and Tablets
    MOJI ADEYEYE; Fiscal Year: 2009
    ..The project's goal is to develop age-appropriate fast disintegrating, fast dissolving (FDFD) granules and tablets of fixed dose combination antiretroviral (ARV) drugs - zidovudine, lamivudine and nevirapine for the pediatric ..
  8. Iron functionalized silica as oral phosphate binder to treat hyperphosphatemia
    Wassana Yantasee; Fiscal Year: 2012
    ..year), low-to-moderate efficacy, gastrointestinal adverse effects, and high pill burdens (500-800 mg tablet, 3-12 tablets a day)...
  9. AGS Guiding Principles for the Care of Older Adults with Multimorbidity: A Mobile
    Nancy Lundebjerg; Fiscal Year: 2013
    ..for Healthcare Research and Quality (AHRQ) to develop a multi-platform application (app) for smartphones and tablets that is based on our MGP and that draws upon the AHRQ National Guideline Clearinghouse in order to provide ..
  10. Tablet-Aided BehavioraL intervention EffecT on Self-management skills (TABLETS)
    Cheryl P Lynch; Fiscal Year: 2013
    ..the effectiveness of a multi-component, Tablet-Aided BehavioraL intervention EffecT on Self- management (TABLETS) intervention on changing behavioral (chronic disease self-management) and clinical outcomes (CVD risk) given the ..
  11. Integrating Patient Generated Family Health History from Varied EHR Entry Portals
    Jennifer S Haas; Fiscal Year: 2010
    ..The pathways will include: : (1) computer tablets in waiting rooms to complete the MFHP, (2) a secure internet portal to transfer data collected by patients at ..
  12. Effects of Estradiol &Phytoestrogens on Stress Responsivity
    Pauline M Maki; Fiscal Year: 2013
    ..Novasoy(R) 400, 55 mg tablet twice daily);2) oral estradiol (1 mg/daily);and 3) placebo (identical appearing tablets twice daily) in 120 healthy women in the menopausal transition (40 per group)...
  13. Healthy Ideas Exchange
    CHIHHUNG JASON WANG; Fiscal Year: 2011
    ..choice architecture called the Healthy Ideas Exchange which will be implemented via the Web using Smartphones and tablets (e.g., iPad)...
  14. Asthma Mobile App Development, Dissemination and Evaluation
    Jonathan D Klein; Fiscal Year: 2013
    ..More and more individuals are using mobile tools such as smartphones and tablets as the primary source of Internet connectivity...
  15. Oral transmucosal drug delivery system for naltrexone for alcohol dependence trea
    HOCK TAN; Fiscal Year: 2009
    ..PROBLEM/OPPORTUNITY: There are two naltrexone products marketed for treatment of alcohol dependence: oral tablets and injectable depot formulation...
  16. Doxazosin an a1 Antagonist for Alcohol Dependence
    GEORGE ANTHONY KENNA; Fiscal Year: 2012
    ..Food and Drug Administration (FDA) for the treatment of alcohol dependence (AD), namely disulfiram, naltrexone tablets and injection, and acamprosate, however treatment success has been inconsistent...
  17. AGE-RELATED GASTRIC CHANGES AND DRUG ABSORPTION
    Aryeh Hurwitz; Fiscal Year: 1993
    ..Enoxacin, 400 mg, will be administered in tablets and solution to twelve elderly (aged 65 and over) acid secretors and twelve nonsecretors identified by prior ..
  18. Functional Assessment Screening Patient Reported Information: FAST-PRI
    Rachel Hess; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The proposed project, Functional Assessment Screening Tablets-Patient Reported Information, has been developed in response to PAR-08-270: Utilizing Health Information Technology to Improve Health ..
  19. A Six-Month, RCT of Probuphine Safety and Efficacy in Opioid Addiction
    Katherine L Beebe; Fiscal Year: 2010
    ..Though the daily dosing of sublingual buprenorphine tablets has proven effective, this treatment has several shortcomings that have lead to significant public health ..
  20. Tablet-based Skills Development of Pain Management Skills
    KAREN ROSSIE; Fiscal Year: 2012
    ..To address this gap we propose to create The Pain Treatment Simulator for Computer Tablets, a computer tablet-based application to provide a learning and shared experience environment for health ..
  21. Thermostable vaginal probiotic microbicide
    VICTOR BRONSHTEIN; Fiscal Year: 2012
    ..In a recent study comparing women's preference between films, tablets and ovules, the film dosage form was shown to have greatest acceptability among women studied...
  22. Oral transmucosal drug delivery system for naltrexone
    HOCK SENG TAN; Fiscal Year: 2013
    ..There are two naltrexone drug products marketed for treatment of alcohol dependence: oral tablets and injectable depot formulation...
  23. Me, A Doc!
    ALVIN REES MIDGLEY; Fiscal Year: 2011
    ..Designed for use in classrooms or by individuals with computers or tablets, this interactive learning tool can be disseminated widely and will lead to enhanced health science literacy of ..
  24. Evaluation of Differing Type 1 Diabetes Regimens in Youth in the Developing World
    Trevor J Orchard; Fiscal Year: 2010
    ..In addition a simplified, and standardized, method of delivering diabetes education via personal computer "tablets" will be developed and evaluated to help compensate for the shortage of trained health care professionals ..
  25. PRE-VIEW An Interactive Video Doctor to Encourage Cancer Screening
    JUDITH MARY EILEEN WALSH; Fiscal Year: 2013
    ..proposal, is to begin to adapt PRE-VIEW in two ways: 1) to a new language (Spanish) and 2) for use with different user interfaces, such as the Internet, cell phones or tablets, while still facilitating patient-physician discussion.
  26. Reduction in medication administration and charting errors in nursing facilities
    ALAN J JACOBS; Fiscal Year: 2013
    ..IdentRx is a novel bench top system capable of determining the composition and dosage of individual pills, tablets and capsules in real-time...
  27. Recovery Roadmap: Person-Centered Care Planning
    Janis Tondora; Fiscal Year: 2013
    ..The two tools - which can be accessed on computers, mobile devices, and tablets - work in tandem to support the overall consumer-provider relationship and create a collaborative, person-..
  28. Novel Rinse to Treat Oral Candidiasis in Cancer Patients
    Bakul Bhatt; Fiscal Year: 2007
    ..Oral candidiasis is generally treated with systemic antifungals or oral rinses. Fluconazole tablets and clotrimazole troches are the most popular therapies...
  29. Can mental health apps work in the real world? A feasibility pilot study
    ADAM H GAZZALEY; Fiscal Year: 2013
    ..provided by applicant): Over two million people in the US download health apps onto their smartphones and tablets, with the intent of improving their quality of life...
  30. Safety and initial efficacy of lisdexamfetamine for methamphetamine dependence
    RAJKUMAR JYOTISHCHANDRA SEVAK; Fiscal Year: 2012
    ..Indeed, d-amphetamine is reportedly abused, primarily by crushing the tablets in order to snort the drug...
  31. Dose-response of cranberry in women with recurrent UTIs
    Lynn Stothers; Fiscal Year: 2010
    ..with prolonged or high levels of cranberry consumption This study is a dose-response trial of cranberry tablets/capsules, comparing the efficacy of 5 dose levels: placebo, very low dose, low dose, medium dose and high dose...
  32. Aminotrexate A Novel Strategy to Replace Methotrexate in Psoriasis
    John A Zebala; Fiscal Year: 2010
    ..of oral AMT in moderate-to-severe plaque psoriasis;and (3) determine if splitting the weekly dose over two tablets, given every 12 hours, is preferred over giving the fully weekly dose once, using PASI scoring and safety ..
  33. Multimedia Lessons for Interactive Whiteboards
    GEORGE NASSIS; Fiscal Year: 2013
    ..MMLs from the current CD format to include delivery via web-based access through a computer, iPad and other tablets/mobile devices...
  34. Artificial Intelligence in a Mobile Intervention for Depression (AIM)
    DAVID CURTIS MOHR; Fiscal Year: 2013
    ..IntelliCare will be designed as a mobile application, but will be accessible via computer web browsers and tablets. The IntelliCare machine learning framework will use individual data obtained from use data (e.g...
  35. Breath Test for Individualizing CD Therapy in Parkinson Disease
    David I Rosen; Fiscal Year: 2010
    ..for each patient will provide for significant improvement over current therapy that uses standardized CD/LD tablets. Our preliminary data suggests that the current CD doses in commercially available CD/LD tablets may be ..
  36. Haptic Sensory Glove for Humans and Robots
    Mandayam A Srinivasan; Fiscal Year: 2012
    ..real, virtual or teleoperated objects;(3) Human-Computer Interfaces: Augmentation of applications involving touch tablets and screens, tactile mouse and haptic interfaces, all applications of virtual reality such as gaming, education ..
  37. Mobile Cadaver Lab: An Innovative Platform to Supplement Medical Education for Mo
    Young Seok Kim; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): With the successful launch of Apple's iPad, the markets for mobile tablets have exploded. Such mobile tablets are fast becoming a standard part of education...
  38. Role of 5-alpha Reductase in Testosterone Actions
    Shalendar Bhasin; Fiscal Year: 2007
    ..randomly assigned to one of 8 groups: group 1, testosterone enanthate (TE) 50-mg weekly, plus placebo tablets daily; group 2, TE 125-mg weekly plus placebo daily; group 3, TE 300-mg weekly plus placebo daily; group 4, TE ..
  39. Optimal assessment of HAART adherence in routine clinical care
    Heidi M Crane; Fiscal Year: 2012
    ..The goal of this study is to validate a novel method of adherence collection using touch-screen tablets for use in clinical care settings focusing on feasibility issues and optimal item selection...
  40. Preventing Alcohol/Prescribed Drug Misuse in the National Guard: Web and Peer BI
    Frederic C Blow; Fiscal Year: 2013
    ..Screenings via touch-screen computer tablets will be used to recruit NG members with alcohol/prescribed opioid or sedative misuse in the prior 3 months...
  41. Novel Methods to Disseminate Knowledge Regarding Molecular Imaging of Cancer
    BRIAN WILLIAM BRESNAHAN; Fiscal Year: 2013
    ..g., smart phones, tablets, and laptops).
  42. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006
    Cellulose acetate phthalate (CAP), used in the pharmaceutical industry for enteric film coating of tablets and capsules, is an HIV-1 entry inhibitor blocking the CXCR4/CCR5 coreceptor binding sites on the virus and eliciting "dead-end" ..
  43. Enabling Mobile Device-Based Stimulus Presentation in Biobehavioral Research
    BRUNO C TAGLIAFERRI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The ubiquity of high-performance mobile devices, such as smartphones and tablets, has the potential to significantly broaden and improve the methods of data collection used in the biobehavioral ..
  44. Automating Directly Observed Therapy as a Platform Technology
    ADAM HANINA; Fiscal Year: 2013
    ..for use in clinical trials which uses sophisticated computer vision technology on webcam- enabled smart phones or tablets to visually confirm medication administration...
  45. Optimizing Brief Alcohol Intervention for Underage Drinkers in the ER
    Maureen A Walton; Fiscal Year: 2013
    ..Therefore, the proposed study will use computerized screening using touch- screen computer tablets with audio (~5,700 patients) and will test developmentally appropriate, tailored intervention strategies in a two-..
  46. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    Cellulose acetate phthalate (CAP) has been used as an enteric film coating material or as a matrix binder for tablets and capsules...
  47. Thermostable vaginal probiotic microbicide
    VICTOR BRONSHTEIN; Fiscal Year: 2013
    ..In a recent study comparing women's preference between films, tablets and ovules, the film dosage form was shown to have greatest acceptability among women studied...
  48. Optimizing SBIRT for Drug-Using Patients in an Inner-City Emergency Department
    Frederic C Blow; Fiscal Year: 2013
    ..Therefore, the proposed study will use computerized screening using touch screen computer tablets with audio (~4,900 patients) and will test intervention strategies in a two-factorial design (3x2)...
  49. Providing Access to Appliance Displays for Visually Impaired Users
    James M Coughlan; Fiscal Year: 2013
    ..Users Summary The goal of this project is to develop a computer vision system that runs on smartphones and tablets to enable blind and visually impaired persons to read appliance displays...
  50. IND 20212 (03-25-99) PHASE 3: ORBEC (ORAL BDP) -PATIENTS WITH GI GVHD-FDA-11-12-0
    KEVIN JAMES HORGAN; Fiscal Year: 2012
    ..whose symptoms have responded to initial treatment, while subjects continue to take the study drug [placebo tablets or an oral topically-active glucocorticoid (beclomethasone dipropionate, BDP)]...
  51. The CERTAIN Hub: A Platform for Improved Patient Data Collection and Stakeholder
    David R Flum; Fiscal Year: 2013
    ..Hub that interfaces with patients in non-clinical and outpatient settings (using computers, mobile devices, tablets, paper) to assess Patient Reported Outcomes (PRO) and other patient perspectives of care...
  52. FLUORIDE EXPOSURES IN YOUNG CHILDREN-LONGITUDINAL PILOT
    Steven Levy; Fiscal Year: 1990
    ..of various caries preventive measures, including fluoridated drinking water, dietary fluoride supplements (tablets and drops) , toothpastes, mouthrinses, and professional (dental office) topical applications...
  53. Live, oral, heat Stable S. typhi TY21a vaccine
    ERIC PATZER; Fiscal Year: 2006
    ..g., quick dissolving thin films or tablets applied directly to the tongue...
  54. DOUBLE-BLIND STUDY FOR LONG-TERM OF ULCER HEMORRHAGE
    Dennis Jensen; Fiscal Year: 1992
    ..Patients will have antacid tablets for prn treatment of ulcer symptoms and will be followed for a mean of 30 months...
  55. EFFICACY OF BITTER TASTE BLOCKERS ON FLAVOR ACCEPTANCE IN PEDIATRIC POPULATIONS
    JULIA ANNE MENNELLA; Fiscal Year: 2013
    ..First, children often cannot or will not swallow pills or tablets (which encapsulates the inherently bitter tasting medications)...
  56. On-screen Keyboard Access Method to Reduce Workload
    THOMAS JAKOBS; Fiscal Year: 2012
    ..a browser- based, on-screen keyboard provides access to a wide variety of devices, including smartphones, tablets, and computers...
  57. A 30-DAY INJECTION FOR TREATMENT OF URINARY INCONTINENCE
    ELIE NUWAYSER; Fiscal Year: 2001
    ..Conventional oxybutynin therapy involves a dose of 5 mg taken 3 times daily in the form of tablets. However, since its oral bioavailability is only 6-9 percent, an injection capable of delivering 1-2 mg/day for ..
  58. Computer-Facilitated 5A's for Smoking Cessation in Primary Care
    Jason M Satterfield; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This study tests the use of handheld computer tablets to promote the integration of 5A's for smoking cessation in academic and community primary care clinics...
  59. Optimizing Alcohol Brief Interventions in the ED: Computer vs. Clinician Delivery
    Frederic C Blow; Fiscal Year: 2013
    ..The proposed study will use computerized screening via touch-screen computer tablets with audio to recruit 750 inner-city ED patients screening positive for at-risk or problem alcohol use...
  60. Allicin bioavailability of garlic products
    Larry Lawson; Fiscal Year: 2009
    ..the past 30 years, nearly 100 clinical trials have been conducted with garlic supplements, mainly garlic powder tablets, on several cardiovascular risk factors...
  61. Advancing Suffolk County's Conformance with the VNRFRPS
    CHRISTOPHER SORTINO; Fiscal Year: 2013
    ..improvements include a computerized test scoring system, a scanner for food service establishment floor plans and tablets for conducting food service inspections...
  62. CCBH Completion of VNRFRPS
    RICK MELENDEZ; Fiscal Year: 2013
    ..New field tablets will replace existing laptops...
  63. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    ..One of the two weeks, 150 mmol supplemental salt will be added as tablets taken with each meal; the total of 200 mmol is the average consumption measured in previous studies of stone ..