powders

Summary

Summary: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)

Top Publications

  1. ncbi Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery
    Lauren Willis
    Department of Pharmaceutical Sciences Drug Development Division, College of Pharmacy, University of Kentucky, 789 S Limestone Street, Lexington, KY 40536 0596, USA
    Lung 190:251-62. 2012
  2. ncbi Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics
    Anthony J Hickey
    Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Campus Box 7360, 1310 Kerr Hall, Kerr Hall, Chapel Hill, North Carolina 27599 7360, USA
    J Pharm Sci 96:1282-301. 2007
  3. ncbi The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    J D Andya
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 16:350-8. 1999
  4. ncbi Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro
    Richard Gminski
    Department of Environmental Health Sciences, University Medical Center Freiburg, D 79106 Freiburg, Germany
    Environ Mol Mutagen 52:296-309. 2011
  5. ncbi The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations
    Jagdeep Shur
    Pharmaceutical Surface Science Group, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Pharm Res 25:1631-40. 2008
  6. ncbi In vitro absorption of metal powders through intact and damaged human skin
    Francesca Larese Filon
    UCO Medicina del Lavoro Dipartimento di Scienze di Medicina Pubblica Università di Trieste, Via della Pieta 19, 34129 Trieste, Italy
    Toxicol In Vitro 23:574-9. 2009
  7. pmc Dustiness of fine and nanoscale powders
    Douglas E Evans
    National Institute for Occupational Safety and Health, Chemical Exposure and Monitoring Branch, Division of Applied Research and Technology, 4676 Columbia Parkway, MS R7, Cincinnati, OH 45226, USA
    Ann Occup Hyg 57:261-77. 2013
  8. ncbi Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age
    Luz María De-Regil
    Micronutrients Unit, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, Geneva, Switzerland, 1211
    Cochrane Database Syst Rev 9:CD008959. 2011
  9. ncbi Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro
    Ana Grenha
    University of Santiago de Compostela, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, 15782 Santiago de Compostela, Spain
    Eur J Pharm Sci 31:73-84. 2007
  10. pmc Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration
    Nashwa El-Gendy
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    Pharm Res 26:1752-63. 2009

Detail Information

Publications307 found, 100 shown here

  1. ncbi Therapeutic liposomal dry powder inhalation aerosols for targeted lung delivery
    Lauren Willis
    Department of Pharmaceutical Sciences Drug Development Division, College of Pharmacy, University of Kentucky, 789 S Limestone Street, Lexington, KY 40536 0596, USA
    Lung 190:251-62. 2012
    Therapeutic liposomal powders (i.e...
  2. ncbi Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics
    Anthony J Hickey
    Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina, Campus Box 7360, 1310 Kerr Hall, Kerr Hall, Chapel Hill, North Carolina 27599 7360, USA
    J Pharm Sci 96:1282-301. 2007
    ..This is the first of two papers that discuss static and dynamic methods of characterizing dry powder inhaler formulations...
  3. ncbi The effect of formulation excipients on protein stability and aerosol performance of spray-dried powders of a recombinant humanized anti-IgE monoclonal antibody
    J D Andya
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 16:350-8. 1999
    To study the effect of trehalose, lactose, and mannitol on the biochemical stability and aerosol performance of spray-dried powders of an anti-IgE humanized monoclonal antibody.
  4. ncbi Genotoxic effects of three selected black toner powders and their dimethyl sulfoxide extracts in cultured human epithelial A549 lung cells in vitro
    Richard Gminski
    Department of Environmental Health Sciences, University Medical Center Freiburg, D 79106 Freiburg, Germany
    Environ Mol Mutagen 52:296-309. 2011
    Until now, the adverse effects of toner powders on humans have been considered to be minimal. However, several recent reports have suggested possible significant adverse health effects from toner dust inhalation...
  5. ncbi The role of fines in the modification of the fluidization and dispersion mechanism within dry powder inhaler formulations
    Jagdeep Shur
    Pharmaceutical Surface Science Group, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    Pharm Res 25:1631-40. 2008
    ..To investigate the role of in situ generated fine excipient particles on the fluidization and aerosolization properties of dry powder inhaler (DPI) formulations...
  6. ncbi In vitro absorption of metal powders through intact and damaged human skin
    Francesca Larese Filon
    UCO Medicina del Lavoro Dipartimento di Scienze di Medicina Pubblica Università di Trieste, Via della Pieta 19, 34129 Trieste, Italy
    Toxicol In Vitro 23:574-9. 2009
    ..The aim of this study was to evaluate the percutaneous penetration of metal powders of cobalt (Co), nickel (Ni) and chromium (Cr) and the effect of skin lesions on skin absorption...
  7. pmc Dustiness of fine and nanoscale powders
    Douglas E Evans
    National Institute for Occupational Safety and Health, Chemical Exposure and Monitoring Branch, Division of Applied Research and Technology, 4676 Columbia Parkway, MS R7, Cincinnati, OH 45226, USA
    Ann Occup Hyg 57:261-77. 2013
    ..developed for pharmaceutical application, was evaluated in the dustiness investigation of 27 fine and nanoscale powders. The device efficiently dispersed small (mg) quantities of a wide variety of fine and nanoscale powders, into a ..
  8. ncbi Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age
    Luz María De-Regil
    Micronutrients Unit, Department of Nutrition for Health and Development, World Health Organization, 20 Avenue Appia, Geneva, Switzerland, 1211
    Cochrane Database Syst Rev 9:CD008959. 2011
    ..Young children are highly vulnerable because of rapid growth and inadequate dietary practices. Micronutrient powders (MNP) are single-dose packets containing multiple vitamins and minerals in powder form that can be sprinkled onto ..
  9. ncbi Chitosan nanoparticles are compatible with respiratory epithelial cells in vitro
    Ana Grenha
    University of Santiago de Compostela, Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, 15782 Santiago de Compostela, Spain
    Eur J Pharm Sci 31:73-84. 2007
    ..Not only do the formulations possess suitable aerodynamic characteristics and the capacity to encapsulate proteins as shown previously; they have now been shown to exhibit in vitro biocompatibility...
  10. pmc Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration
    Nashwa El-Gendy
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    Pharm Res 26:1752-63. 2009
    ..Concurrently, aerosolized chemotherapy is generating interest as a means to treat certain types of lung cancer more effectively with less systemic exposure to the compound...
  11. ncbi Technological and biological evaluation of tablets containing different strains of lactobacilli for vaginal administration
    L Maggi
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    Eur J Pharm Biopharm 50:389-95. 2000
    ..A larger batch of tablets made with a mixture of the three strains was then evaluated, confirming the feasibility of their industrial production and a good bacterial viability in the final dosage form...
  12. pmc Safety, efficacy and convenience of tobramycin inhalation powder in cystic fibrosis patients: The EAGER trial
    Michael W Konstan
    Rainbow Babies and Children s Hospital, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    J Cyst Fibros 10:54-61. 2011
    ....
  13. pmc Micronutrient sprinkles to control childhood anaemia
    Stanley H Zlotkin
    Division of GI Nutrition at the Hospital for Sick Children, Toronto, Ontario, Canada
    PLoS Med 2:e1. 2005
  14. ncbi Cyclodextrins in the production of large porous particles: development of dry powders for the sustained release of insulin to the lungs
    Francesca Ungaro
    Department of Pharmaceutical and Toxicological Chemistry, University of Napoli Federico II, Via Domenico Montesano 49, 80131 Napoli, Italy
    Eur J Pharm Sci 28:423-32. 2006
    The aim of this work was to develop dry powders intended for insulin pulmonary delivery...
  15. pmc Physicochemical characterization and water vapor sorption of organic solution advanced spray-dried inhalable trehalose microparticles and nanoparticles for targeted dry powder pulmonary inhalation delivery
    Xiaojian Li
    Department of Pharmaceutical Sciences Drug Development Division, University of Kentucky College of Pharmacy, Lexington, 40536 0596, USA
    AAPS PharmSciTech 12:1420-30. 2011
    Novel advanced spray-dried inhalable trehalose microparticulate/nanoparticulate powders with low water content were successfully produced by organic solution advanced spray drying from dilute solution under various spray-drying ..
  16. pmc Reduction of common cold symptoms by encapsulated juice powder concentrate of fruits and vegetables: a randomised, double-blind, placebo-controlled trial
    Stephanie Roll
    Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Centre, Luisenstrasse 57, 10098 Berlin, Germany
    Br J Nutr 105:118-22. 2011
    ..Intake of a dietary supplement from fruits and vegetables was associated with a 20 % reduction of moderate or severe common cold symptom days in healthcare professionals particularly exposed to patient contact...
  17. ncbi Advancements in dry powder delivery to the lung
    Yoen Ju Son
    College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    Drug Dev Ind Pharm 34:948-59. 2008
    ..This article reviews DPI devices currently available, advantages of newly developed devices, outlines some requirements for future device design...
  18. ncbi Bactericidal activities of health-promoting, food-derived powders against the foodborne pathogens Escherichia coli, Listeria monocytogenes, Salmonella enterica, and Staphylococcus aureus
    Mendel Friedman
    Western Regional Research Center, Agricultural Research Service USDA, Produce Safety and Microbiology Research Unit, Albany, CA 94710, USA
    J Food Sci 78:M270-5. 2013
    We evaluated the relative bactericidal activities (BA(50) ) of 10 presumed health-promoting food-based powders (nutraceuticals) and, for comparison, selected known components against the following foodborne pathogens: Escherichia coli ..
  19. ncbi Physical characterization of component particles included in dry powder inhalers. II. Dynamic characteristics
    Anthony J Hickey
    Division of Molecular Pharmaceutics, School of Pharmacy, University of North Carolina at Chapel Hill, Campus Box 7360, 1310 Kerr Hall, Chapel Hill, North Carolina 27599 7360, USA
    J Pharm Sci 96:1302-19. 2007
    ..The proposed series of analytical approaches to the evaluation of powders for inclusion in aerosol products has merit and may be the basis for screening and ultimately predicting particle ..
  20. ncbi Agglomerate strength and dispersion of salmeterol xinafoate from powder mixtures for inhalation
    Handoko Adi
    Department of Pharmaceutics, Victorian College of Pharmacy, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Pharm Res 23:2556-65. 2006
    ..The study investigated the role of agglomeration and the effect of fine lactose size on the dispersion of salmeterol xinafoate (SX) from SX-lactose mixtures for inhalation...
  21. ncbi An investigation into the relationship between carrier-based dry powder inhalation performance and formulation cohesive-adhesive force balances
    Matthew D Jones
    Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
    Eur J Pharm Biopharm 69:496-507. 2008
    ..It was concluded, therefore, that when developing a carrier-based DPI, the selection of a drug-carrier combination with a slightly cohesive CAB ratio might result in optimal performance...
  22. ncbi Deagglomeration of dry powder pharmaceutical aerosols
    Austin Voss
    Aerosol Research Laboratory, Department of Mechanical Engineering, University of Alberta, Edmonton, Alta, Canada T6G 2G8
    Int J Pharm 248:39-50. 2002
    ..The humidified powders were significantly more difficult to deaggregate, giving a FPF(ED<5...
  23. ncbi The use of absorption enhancers to enhance the dispersibility of spray-dried powders for pulmonary gene therapy
    H Y Li
    Gene Delivery Research Group, Welsh School of Pharmacy, Cardiff University, Cardiff CF10 3XF, UK
    J Gene Med 7:1035-43. 2005
    ..In this study, we investigate whether certain absorption enhancers may also enhance the aerosolisation properties of spray-dried powders containing non-viral gene vectors.
  24. ncbi Preparation and characterization of spray-dried tobramycin powders containing nanoparticles for pulmonary delivery
    Gabrielle Pilcer
    Laboratory of Pharmaceutics and Biopharmaceutics, Universite Libre de Bruxelles, Belgium
    Int J Pharm 365:162-9. 2009
    ..The results from the spray-dried powders showed that the presence of nanoparticles in the formulations improved particle dispersion properties during ..
  25. ncbi The cohesive-adhesive balances in dry powder inhaler formulations II: influence on fine particle delivery characteristics
    Philippe Begat
    Pharmaceutical Technology Research Group, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, United Kingdom
    Pharm Res 21:1826-33. 2004
    ..To investigate the influence of the cohesive-adhesive balances on dry powder formulation aerosolization and delivery characteristics...
  26. ncbi Efficacy of three topical hemostatic agents applied by medics in a lethal groin injury model
    Vance Y Sohn
    Department of Surgery and the Andersen Simulation Center, Madigan Army Medical Center, Tacoma, Washington 98431, USA
    J Surg Res 154:258-61. 2009
    ..We sought to determine the efficacy of three chitosan based hemostatic agents in a lethal groin injury model when applied by combat medic first responders...
  27. ncbi Formulation and characterization of spray-dried powders containing nanoparticles for aerosol delivery to the lung
    Jeffrey O H Sham
    Department of Radiation Oncology, Cross Cancer Institute, Edmonton, Alta, Canada T6G 1Z2
    Int J Pharm 269:457-67. 2004
    Spray-drying is a common practice of powder preparation for a wide range of drugs. Spray-dried powders can be used to deliver particles to the lungs via a dry powder inhaler (DPI)...
  28. ncbi Formulation and in vivo evaluation of sodium alendronate spray-dried microparticles intended for lung delivery
    Leticia Cruz
    Programa de Pós Graduação em Ciências Farmacêuticas, Curso de Farmácia, Universidade Federal de Santa Maria, Santa Maria, Brazil
    J Control Release 152:370-5. 2011
    Spray-dried powders for lung delivery of sodium alendronate (SA) were prepared from hydroalcoholic solutions. Formulations display geometric particle size below to 12 μm and spherical shape associated to a hollow structure...
  29. pmc Preparation of mesoporous and/or macroporous SnO2-based powders and their gas-sensing properties as thick film sensors
    Luyang Yuan
    Graduate School of Science and Technology, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Sensors (Basel) 11:1261-76. 2011
    Mesoporous and/or macroporous SnO(2)-based powders have been prepared and their gas-sensing properties as thick film sensors towards H(2) and NO(2) have been investigated...
  30. ncbi Investigation of jewelry powders radiating far-infrared rays and the biological effects on human skin
    B H Yoo
    Skin Research Institute, Pacific Corp R and D Center, 314 1, Bora ri Kiheung eup, Yongin si, Kyounggi Do, Korea 449 900
    J Cosmet Sci 53:175-84. 2002
    ..Some jewelry powders radiate far-infrared rays...
  31. ncbi Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze-dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling
    B van Eerdenbrugh
    Laboratory for Pharmacotechnology and Biopharmacy, K U Leuven, Gasthuisberg O and N2, Herestraat 49, box 921, 3000 Leuven, Belgium
    Int J Pharm 338:198-206. 2007
    ..A Caco-2 experiment on the nanopowder showed a significantly higher cumulative amount transported after 120min (1.59+/-0.02microg) compared to the physical mixture (0.93+/-0.01microg) and the untreated loviride (0.74+/-0.03mcirog)...
  32. ncbi Preparation of drug nanoparticle-containing microparticles using a 4-fluid nozzle spray drier for oral, pulmonary, and injection dosage forms
    Takuto Mizoe
    Laboratory of Pharmaceutics and Drug Delivery, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo, Japan
    J Control Release 122:10-5. 2007
    ..This study demonstrated that it is possible to use the 4-fluid spray drier to prepare microparticles containing PLH nanoparticles that that improve drug absorption and can be administered by oral, pulmonary, and injection routes...
  33. ncbi Use of solid corrugated particles to enhance powder aerosol performance
    N Y Chew
    Faculty of Pharmacy, University of Sydney, NSW, Australia
    Pharm Res 18:1570-7. 2001
    ..with a focus on the effect of particle surface morphology on aerosolization of bovine serum albumin (BSA) powders. METHODS: The solid-state characteristics of the spray-dried BSA powders, one consisting of smooth spherical ..
  34. ncbi Comparison of particle sizing techniques in the case of inhalation dry powders
    C Bosquillon
    , School of Pharmacy, Department of Pharmaceutical Technology, Avenue E. Mounier, 73 UCL 73.20, 1200 Brussels, Belgium
    J Pharm Sci 90:2032-41. 2001
    ..zone sensing and laser diffraction for the analysis of primary particle size in the case of inhalation dry powders and (ii) to study the influence of the aggregation state of the powder on the sizing techniques...
  35. ncbi Pulmonary delivery of growth hormone using dry powders and visualization of its local fate in rats
    Cynthia Bosquillon
    Department of Pharmaceutical Technology, Universite Catholique de Louvain, School of Pharmacy, avenue E Mounier, 73 UCL 73 20, 1200 Brussels, Belgium
    J Control Release 96:233-44. 2004
    ..A dry powder aerosol made of selected GRAS excipients improved absorption of hGH from the lung over a simple solution...
  36. ncbi Novel sustained release microspheres for pulmonary drug delivery
    Robert O Cook
    Department of Pharmaceutics, University of London School of Pharmacy, 29 39 Brunswick Square, London, WC1N 1AX, UK
    J Control Release 104:79-90. 2005
    ..The sustained release microspheres were formulated as a carrier-free dry powder for inhalation, and exhibited a favourable Fine Particle Fraction (FPF) of 46.5+/-1.8% and Mass Median Aerodynamic Diameter (MMAD) of 3.93+/-0.12 microm...
  37. ncbi Gynecologic use of Sepraspray Adhesion Barrier for reduction of adhesion development after laparoscopic myomectomy: a pilot study
    Gregory T Fossum
    Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    Fertil Steril 96:487-91. 2011
    ....
  38. ncbi Effect of particle size of dry powder mannitol on the lung deposition in healthy volunteers
    William Glover
    Advanced Drug Delivery Group, Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia
    Int J Pharm 349:314-22. 2008
    ..Three different sized radiolabelled powders were produced by co-spray drying mannitol with 99mTc-DTPA...
  39. ncbi Conversion of nanosuspensions into dry powders by spray drying: a case study
    Mahesh V Chaubal
    Baxter Healthcare Corporation, Route 120 and Wilson Rd, Round Lake, Illinois 60073, USA
    Pharm Res 25:2302-8. 2008
    ..This case study examines impact of various formulation and processing parameters on redispersibility of the spray dried nanoparticles...
  40. ncbi Spray-dried respirable powders containing bacteriophages for the treatment of pulmonary infections
    Sadaf Matinkhoo
    Department of Mechanical Engineering, University of Alberta, Edmonton, Alberta T6G 2G8, Canada
    J Pharm Sci 100:5197-205. 2011
    ..4 to 0.8 log pfu. The aerosol performance of the resulting dry powders as delivered from an Aerolizer® dry powder inhaler (DPI) exceeded the performance of commercially available DPIs;..
  41. ncbi Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process
    Norbert Rasenack
    Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Gutenbergstr 76, D 24118 Kiel, Germany
    J Pharm Sci 92:35-44. 2003
    ..1 (ECU-R2), fine particle fractions of 25.6% (BDP) resp. 78.2% (ECU-R2) are obtained with the spray-dried powders. As the formation of the small crystals requires a rapid solvent change process, the affinity of the hydrocolloid,..
  42. pmc Raman characterization and chemical imaging of biocolloidal self-assemblies, drug delivery systems, and pulmonary inhalation aerosols: a review
    Heidi M Mansour
    University of North Carolina at Chapel Hill, School of Pharmacy, Division of Molecular Pharmaceutics, Campus Box 7360, 311 Pharmacy Lane, 1311 Kerr Hall, Dispersed Systems Laboratory, Chapel Hill, NC 27599 7360, USA
    AAPS PharmSciTech 8:E99. 2007
    ..properties that Raman characterization can provide are particularly important in respirable pharmaceutical powders, as these particles possess a higher surface-area-to-volume ratio; hence, understanding the nature of these solid ..
  43. ncbi Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway
    Masahiro Ohgidani
    Division of Applied Life Science, Graduate School of Engineering, Sojo University, 4 22 1 Ikeda, Kumamoto 860 0082, Japan
    J Biosci Bioeng 114:104-9. 2012
    ..The findings in this study suggest that PSDR has the possibility of therapeutic and/or preventive agents of HCC...
  44. ncbi Nanoparticle realgar powders induce apoptosis in U937 cells through caspase MAPK and mitochondrial pathways
    Xiao Bo Wang
    School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    Arch Pharm Res 30:653-8. 2007
    Nanoparticle realgar powders (NRP) inhibited U937 cell growth in a time and dose-dependent manner. U937 cells treated with NRP showed typical characteristics of apoptosis including the morphological changes and DNA fragmentation...
  45. ncbi A novel spray-drying technique to produce low density particles for pulmonary delivery
    Hartwig Steckel
    Department of Pharmaceutics and Biopharmaceutics, Christian Albrecht University Kiel, Gutenbergstrasse 76, 24118 Kiel, Germany
    Int J Pharm 278:187-95. 2004
    To date, all marketed DPI products rely on jet-milled, micronized drugs. Micronization often leads to drug powders exhibiting a large hydrophobic surface area resulting in strong cohesive forces, agglomeration and unsuitable ..
  46. ncbi Printability of calcium phosphate powders for three-dimensional printing of tissue engineering scaffolds
    Andre Butscher
    RMS Foundation, Bettlach, Switzerland
    Acta Biomater 8:373-85. 2012
    ..3-1.4, flowability in the range of 5-7 and powder bed surface roughness of 10-25 μm. Finally, possible steps and strategies in pushing the physical limits concerning improved quality in 3DP are addressed and discussed...
  47. ncbi Electrochemical properties of yolk-shell-structured CuO-Fe(2)O(3) powders with various Cu/Fe molar ratios prepared by one-pot spray pyrolysis
    Kwang Min Yang
    Department of Chemical Engineering, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701 Korea, Fax 82 2 4583504
    ChemSusChem 6:2299-303. 2013
    Several yolk-shell-structured CuO-Fe2 O3 powders with various Cu/Fe molar ratios have been successfully prepared under equivalent reaction conditions using a one-pot spray pyrolysis process...
  48. ncbi Bioavailability of elemental iron powders to rats is less than bakery-grade ferrous sulfate and predicted by iron solubility and particle surface area
    James H Swain
    U S Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND, USA
    J Nutr 133:3546-52. 2003
    ..However, the nutritional efficacy of current, commercially produced elemental iron powders has not been verified...
  49. ncbi The influence of drug morphology on aerosolisation efficiency of dry powder inhaler formulations
    Handoko Adi
    Advanced Drug Delivery Group, University of Sydney, Sydney, NSW 2006, Australia
    J Pharm Sci 97:2780-8. 2008
    ..The use of corrugated drug particle morphology in drug carrier DPI systems may lead to improved aerosol performance through reduced drug carrier contact area...
  50. ncbi Dependence of photocatalytic activity of anatase powders on their crystallinity
    Michio Inagaki
    Faculty of Engineering, Aichi Institute of Technology, Yakusa, Toyota 470 0392, Japan
    Chemosphere 64:437-45. 2006
    ....
  51. ncbi Preparation and characterization of spray dried inhalable powders containing chitosan nanoparticles for pulmonary delivery of isoniazid
    Pejman Sadegh Pourshahab
    Aerosol Research Laboratory, Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
    J Microencapsul 28:605-13. 2011
    The aim of this study was to prepare spray dried inhalable powders containing isoniazid-loaded chitosan/tripolyphosphate (TPP) nanoparticles for sustained delivery of the drug to the lung...
  52. ncbi Chitosan-based spray-dried respirable powders for sustained delivery of terbutaline sulfate
    Tristan P Learoyd
    School of Life and Health Sciences, Aston University, Birmingham, UK
    Eur J Pharm Biopharm 68:224-34. 2008
    In this study, we describe the preparation of highly dispersible dry powders for pulmonary drug delivery that display sustained drug release characteristics...
  53. ncbi Bioactive composites consisting of PEEK and calcium silicate powders
    Ill Yong Kim
    Graduate School of Engineering, Nagoya University, Furo cho Chikusa, Nagoya 464 8603, Japan
    J Biomater Appl 24:105-18. 2009
    ..The mechanical properties of the composites are evaluated by three-point bending test. The composites reinforced with 20 vol% CS particles show 123.5 MPa and 6.43 GPa in bending strength and Young's modulus, respectively...
  54. pmc Formulation of a dry powder influenza vaccine for nasal delivery
    Robert J Garmise
    School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    AAPS PharmSciTech 7:E19. 2006
    ..b>Powders containing WIIV and either lactose or trehalose were produced by lyophilization...
  55. ncbi Trileucine improves aerosol performance and stability of spray-dried powders for inhalation
    David Lechuga-Ballesteros
    Nektar Therapeutics, 150 Industrial Road, San Carlos, CA 94070, USA
    J Pharm Sci 97:287-302. 2008
    ..In the present study, we describe the use of trileucine for the preparation of dry powders suitable for inhalation via spray drying of a wide range of drugs (i.e...
  56. ncbi Optimization of formulation components and characterization of large respirable powders containing high therapeutic payload
    Bijay Kumar Padhi
    Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The MS University of Baroda, Vadodara, Gujarat, India
    Pharm Dev Technol 11:465-75. 2006
    The aim of the study was to optimize and characterize high therapeutic payload large respirable powders prepared by spray-drying technique for maximum fine particle fraction with minimum quantities of excipients...
  57. ncbi Epidermal powder immunization of mice and monkeys with an influenza vaccine
    Dexiang Chen
    PowderJect Vaccines, Inc, 585 Science Drive, Madison, WI 53711, USA
    Vaccine 21:2830-6. 2003
    ..This study suggests that EPI is a promising technique for administering human vaccine and that QS-21 augments the immunogenicity of co-administered influenza vaccine...
  58. ncbi Processing of a porous titanium alloy from elemental powders using a solid state isothermal foaming technique
    Aris W Nugroho
    Department of Mechanical Engineering, Curtin University of Technology, GPO Box U1987, Perth, WA, 6845, Australia
    J Mater Sci Mater Med 21:3103-7. 2010
    ..to the potential to manufacture porous titanium alloys for biomedical applications using toxic-free elemental powders, i.e...
  59. pmc Excellent capability in degrading azo dyes by MgZn-based metallic glass powders
    Jun qiang Wang
    WPI Advanced Institute of Materials Research, Tohoku University, Sendai 980 8577, Japan
    Sci Rep 2:418. 2012
    ..In this letter, we report for the first time that the MgZn-based metallic glass powders have excellent functional ability in degrading azo dyes which are typical organic water pollutants...
  60. pmc New inhalation-optimized itraconazole nanoparticle-based dry powders for the treatment of invasive pulmonary aspergillosis
    Christophe Duret
    Laboratoire de Pharmacie Galénique et de Biopharmacie, Universite Libre de Bruxelles, Brussels, Belgium
    Int J Nanomedicine 7:5475-89. 2012
    Itraconazole (ITZ) dry powders for inhalation (DPI) composed of nanoparticles (NP) embedded in carrier microparticles were prepared and characterized.
  61. pmc The effect of calcium hydroxide on the steroid component of Ledermix and Odontopaste
    M Athanassiadis
    Australian Dental Manufacturing, Brisbane, QLD, Australia
    Int Endod J 44:1162-9. 2011
    ..To investigate the chemical interaction of calcium hydroxide with the corticosteroid triamcinolone acetonide in Ledermix Paste and in Odontopaste, a new steroid/antibiotic paste...
  62. pmc Pulmonary drug delivery. Part II: the role of inhalant delivery devices and drug formulations in therapeutic effectiveness of aerosolized medications
    N R Labiris
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Br J Clin Pharmacol 56:600-12. 2003
    ....
  63. ncbi High azithromycin loading powders for inhalation and their in vivo evaluation in rats
    Yu Zhang
    Department of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
    Int J Pharm 395:205-14. 2010
    The aim of the present work is to develop high azithromycin loading powders for inhalation with optimal physical and aerodynamic properties, and to test their in vivo potential in rats...
  64. ncbi Predicting the aerosol performance of dry powder inhalation formulations by interparticulate interaction analysis using inverse gas chromatography
    Henry H Y Tong
    School of Health Sciences, Macao Polytechnic Institute, Macao, China
    J Pharm Sci 95:228-33. 2006
    ..gas chromatography (IGC) in discriminating the differences in surface energy between salmeterol xinafoate (SX) powders prepared by conventional sequential batch crystallization and micronization and by supercritical fluid ..
  65. ncbi The cohesive-adhesive balances in dry powder inhaler formulations I: Direct quantification by atomic force microscopy
    Philippe Begat
    Pharmaceutical Technology Research Group, Department of Pharmacy and Pharmacology, University of Bath Bath, BA2 7AY, UK
    Pharm Res 21:1591-7. 2004
    ..To obtain a quantitative assessment of the cohesive and adhesive force balance within dry powder inhaler formulations...
  66. ncbi In vitro evaluation of powders for inhalation: the effect of drug concentration on particle detachment
    V N P Le
    University Lille Nord de France, College of Pharmacy, 3 rue du Professeur Laguesse, Lille, France
    Int J Pharm 424:44-9. 2012
    Limited information on the effect of the drug concentration on the performance of powders for inhalation is currently published...
  67. ncbi Effects of milk powders in milk chocolate
    B Liang
    Department of Food Science, University of Wisconsin, 1605 Linden Drive, Madison 53706, USA
    J Dairy Sci 87:20-31. 2004
    The physical characteristics of milk powders used in chocolate can have significant impact on the processing conditions needed to make that chocolate and the physical and organoleptic properties of the finished product...
  68. ncbi Kinetic energy density and agglomerate abrasion rate during blending of agglomerates into powders
    Tofan A Willemsz
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Eur J Pharm Sci 45:211-5. 2012
    ..It appeared possible to include effects of filler particle size and impeller rotational rate into this concept. A clear relationship between abrasion rate of agglomerates and the value of St(Abr) was demonstrated...
  69. ncbi Surface characterization of 7S and 11S globulin powders from soy protein examined by X-ray photoelectron spectroscopy and scanning electron microscopy
    Xiaoyan Zhao
    Institute of Agro food Science and Technology, Shandong Academy of Agricultural Sciences, No 202, Gongyebei Road, Jinan 250100, China
    Colloids Surf B Biointerfaces 86:260-6. 2011
    In this study the surface composition of 7S and 11S globulin powders from soybean proteins by aqueous buffer and reverse micelle extractions had been examined using X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (..
  70. ncbi Thermal insight of mechanically activated bile acid powders
    Takanori Ito
    Department of Industrial and Physical Pharmacy, Purdue University, West Lafayette, IN 47907, USA
    Int J Pharm 420:68-75. 2011
    ..The XRPD results for the 30-min milled crystalline powders displayed a characteristic amorphous halo patterns for all compounds tested...
  71. ncbi Comparison of the anti-tumor effects of two platinum agents (miriplatin and fine-powder cisplatin)
    Shobu Watanabe
    Department of Radiology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Cardiovasc Intervent Radiol 35:399-405. 2012
    ..This study was designed to evaluate the anti-tumor effects of miriplatin-lipidol and fine-powder cisplatin-lipiodol suspensions...
  72. ncbi Deaggregation of nanodiamond powders using salt- and sugar-assisted milling
    Amanda Pentecost
    Department of Materials Science and Engineering, A J Drexel Nanotechnology Institute, Drexel University, Philadelphia, Pennsylvania 19104, USA
    ACS Appl Mater Interfaces 2:3289-94. 2010
    ....
  73. ncbi Physicochemical properties of the amorphous drug, cast films, and spray dried powders to predict formulation probability of success for solid dispersions: etravirine
    Ilse Weuts
    Chemical and Pharmaceutical Development, Johnson and Johnson, Beerse, Belgium
    J Pharm Sci 100:260-74. 2011
    ..Cast films can provide early information on miscibility and stabilization and assessment of processed powders can help define requirements and identify issues with potential final formulations.
  74. ncbi Effect of spray drying and subsequent processing conditions on residual moisture content and physical/biochemical stability of protein inhalation powders
    Y F Maa
    Pharmaceutical Research and Development, Genentech, Inc, South San Francisco, California 94080, USA
    Pharm Res 15:768-75. 1998
    ..and powder processing environments on the residual moisture content and aerosol performance of inhalation protein powders. Also, the long-term effect of storage conditions on the powder's physical and biochemical stability was presented...
  75. ncbi Budesonide nanoparticle agglomerates as dry powder aerosols with rapid dissolution
    Nashwa El-Gendy
    Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, Kansas 66047, USA
    J Pharm Sci 98:2731-46. 2009
    ..In addition, processing such suspensions into dry powders can yield broad particle size distributions...
  76. ncbi Nickel release and surface characteristics of fine powders of nickel metal and nickel oxide in media of relevance for inhalation and dermal contact
    Neda Mazinanian
    KTH Royal Institute of Technology, Division of Surface and Corrosion Science, School of Chemical Science and Engineering, 100 44 Stockholm, Sweden
    Regul Toxicol Pharmacol 65:135-46. 2013
    ..release have been investigated in two thoroughly characterized micron-sized (mainly <4 μm) nickel metal powders and a nickel oxide bulk powder when immersed in two different synthetic fluids, artificial sweat (ASW-pH 6...
  77. ncbi Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH
    Shyamal Das
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Victoria 3052, Australia
    Eur J Pharm Sci 38:347-54. 2009
    ..The mechanism of decreased dispersibility was related to increased capillary/solid bridging interactions and to possible increased interaction of contiguous particles due to increased polar surface energy...
  78. ncbi Genetic polymorphisms of ADRB2 and IL10 may be associated with the risk of IgE sensitization to digestive powders in exposed medical personnel
    Young Min Ye
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Yongtong Gu, Suwon, Korea
    Int Arch Allergy Immunol 153:193-200. 2010
    ..The aim of the study was to identify genetic factors associated with IgE sensitization to digestive powders containing pancreatic extract.
  79. ncbi Back to basics: the development of a simple, homogenous, two-component dry-powder inhaler formulation for the delivery of budesonide using miscible vinyl polymers
    F Buttini
    Department of Pharmacy, University of Parma, Area delle Scienze, 43100 Parma, Italy
    J Pharm Sci 97:1257-67. 2008
    ..8 +/- 1.0% and reduced the force of adhesion from 410 +/- 182 to 241 +/- 82 nN with smooth lactose. This illustrates that vinyl polymers could effectively modify adhesive interactions without the need for ternary components such as fines...
  80. ncbi Altered chemical and biological activities of all-trans retinoic acid incorporated in solid lipid nanoparticle powders
    Soo Jeong Lim
    Research Institute, National Cancer Center, Goyang, Gyeonggi, Korea
    J Control Release 100:53-61. 2004
    ..SLN powder formulation of ATRA may have a potential in enhancing the efficacy of ATRA in cancer chemoprevention and therapeutics...
  81. ncbi Experimental observations of dry powder inhaler dose fluidisation
    Rob Tuley
    Mechanical Engineering Department, Imperial College London, UK
    Int J Pharm 358:238-47. 2008
    ..Both lactose powders exhibit fracture characteristics, while aluminium and glass powders fluidise as an erosion...
  82. ncbi Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies
    Richard S Kaye
    Centre for Drug Delivery Research, The School of Pharmacy, University of London, 29 39 Brunswick Square, London WC1N 1AX, UK
    J Pharm Sci 98:4055-68. 2009
    ....
  83. ncbi Powder strength distributions for understanding de-agglomeration of lactose powders
    Shyamal C Das
    Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Parkville, Victoria, 3052, Australia
    Pharm Res 29:2926-35. 2012
    ..The purpose was to calculate distributions of powder strength of a cohesive bed to explain the de-agglomeration of lactose...
  84. pmc Potential for inhalation exposure to engineered nanoparticles from nanotechnology-based cosmetic powders
    Yevgen Nazarenko
    Department of Environmental Sciences, Rutgers University, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    Environ Health Perspect 120:885-92. 2012
    ..The market of nanotechnology-based consumer products is rapidly expanding, and the lack of scientific evidence describing the accompanying exposure and health risks stalls the discussion regarding its guidance and regulation...
  85. ncbi Improvement of flow and bulk density of pharmaceutical powders using surface modification
    Laila J Jallo
    New Jersey Center for Engineered Particulates, New Jersey Institute of Technology, 138 Warren Street, Newark, NJ 07102 1982, USA
    Int J Pharm 423:213-25. 2012
    ..in flow and bulk density, the two most important properties that determine the ease with which pharmaceutical powders can be handled, stored and processed, is done through surface modification...
  86. ncbi [Preparation and evaluation of chitosan/alginate microsphere as a novel biodegradable haemostatic powder]
    Yaping Liu
    Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21:829-32. 2007
    ..To explore a way to make a new kind of chitosan-based microsphere (MS), which can be used as a novel biodegradable haemostatic powder, and to confirm its haemostatic efficiency...
  87. ncbi Characterisation of a carrier-free dry powder aerosol formulation using inertial impaction and laser diffraction
    Gary P Martin
    King s College London, Pharmaceutical Science Research Division, Franklin Wilkins Building, 150 Stamford Street, London SE1 9NH, UK
    Pharm Res 23:2210-9. 2006
    ..The purpose of the study was to examine the suitability of using laser diffraction to measure the fine particle fraction (FPF) of drugs emitted from carrier-free dry powder aerosol formulations...
  88. ncbi New respirable and fast dissolving itraconazole dry powder composition for the treatment of invasive pulmonary aspergillosis
    Christophe Duret
    Laboratoire de Pharmacie Galénique et de Biopharmacie, Universite Libre de Bruxelles, Boulevard du Triomphe CP207 Campus de la Plaine, 1050, Brussels, Belgium
    Pharm Res 29:2845-59. 2012
    Novel itraconazole (ITZ)-based dry powders for inhalation (DPI) were optimized for aerodynamic and dissolution properties and contained excipients that are acceptable for inhalation.
  89. ncbi Effects of Fe-doping on the photocatalytic activity of mesoporous TiO2 powders prepared by an ultrasonic method
    Minghua Zhou
    State Key Laboratory of Advanced Technology for Material Synthesis and Processing, Wuhan University of Technology, Luoshi Road 122, Wuhan 430070, PR China
    J Hazard Mater 137:1838-47. 2006
    Highly photoactive nanocrystalline mesoporous Fe-doped TiO(2) powders were prepared by the ultrasonic-induced hydrolysis reaction of tetrabutyl titanate (Ti(OC(4)H(9))(4)) in a ferric nitrate aqueous solution (pH 5) without using any ..
  90. ncbi Solid dispersions of itraconazole for inhalation with enhanced dissolution, solubility and dispersion properties
    Christophe Duret
    Laboratoire de Pharmacie Galénique et de Biopharmacie, Universite Libre de Bruxelles, Brussels, Belgium
    Int J Pharm 428:103-13. 2012
    ..2 ± 0.4%. This study showed that mannitol solid dispersions may provide an effective formulation type for producing DPIs of poorly soluble active ingredients, as exemplified by ITZ...
  91. ncbi The CFC to HFA transition and its impact on pulmonary drug development
    Chet L Leach
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Respir Care 50:1201-8. 2005
    ..The transition from CFCs also spurred novel new drug-delivery technologies, improved dry powder inhalers, and highly dispersible engineered powders.
  92. ncbi Force control and powder dispersibility of spray dried particles for inhalation
    Claudius Weiler
    Boehringer Ingelheim Pharma GmbH and Co KG, 55216 Ingelheim, Germany
    J Pharm Sci 99:303-16. 2010
    ..of the correlation between particle morphology, cohesion forces, and aerosol performance of spray dried powders for inhalation...
  93. ncbi Determining the dustiness of powders--a comparison of three measuring devices
    Sylvia Bach
    Department of Safety Engineering Environmental Protection, University of Wuppertal, Rainer Gruenter Str, Building FF 42119, Wuppertal
    Ann Occup Hyg 52:717-25. 2008
    The dustiness of 12 test powders was determined using three different measuring methods...
  94. ncbi Agglomerate properties and dispersibility changes of salmeterol xinafoate from powders for inhalation after storage at high relative humidity
    Shyamal Das
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Victoria 3052, Australia
    Eur J Pharm Sci 37:442-50. 2009
    ..This study investigated changes in agglomeration and the mechanism of dispersibility decrease of salmeterol xinafoate (SX) from SX-lactose mixtures for inhalation after storage at 75% RH for 3 months...
  95. pmc Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler
    Hf Salem
    Department of Pharmaceutics, The Universityof Beni Suef, Beni Suef
    Int J Nanomedicine 6:311-20. 2011
    ..In the lungs, they fall apart to reform nanoparticles, thus enhancing the dissolution rate of the drugs. Theophylline is a bronchodilator with poor solubility in water...
  96. ncbi Blending of agglomerates into powders 1: Quantification of abrasion rate
    Tofan A Willemsz
    Department of Pharmaceutical Technology and Biopharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Int J Pharm 387:87-92. 2010
    ..This is often a slow process and the rate is determined not only by the (mechanical) properties of the agglomerates and process conditions, but also by the particle size distribution of the bulk filler...
  97. pmc Novel sample preparation method for safe and rapid detection of Bacillus anthracis spores in environmental powders and nasal swabs
    Vicki A Luna
    Center for Biological Defense, Department of Environmental and Occupational Health, College of Public Health, University of South Florida, Tampa, Florida 33612, USA
    J Clin Microbiol 41:1252-5. 2003
    ..We wanted to develop a safe, rapid method of sample preparation that provided safe DNA for the detection of spores in environmental and clinical specimens. Our method reproducibly detects B. anthracis in samples containing <10 spores...
  98. ncbi Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation
    Shyamal Das
    Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University Parkville Campus, 381 Royal Parade, Victoria 3052, Australia
    J Pharm Sci 98:1015-27. 2009
    ....
  99. ncbi Comparison of the chemopreventive efficacies of garlic powders with different alliin contents against aflatoxin B1 carcinogenicity in rats
    Raymond Berges
    Unité Mixte de Recherche de Toxicologie Alimentaire, Institut National de la Recherche Agronomique, 17 rue Sully, 21065 Dijon, France
    Carcinogenesis 25:1953-9. 2004
    ..The present study was designed to compare the chemopreventive efficacies of several garlic powders with various levels of alliin, a precursor of active sulfur compounds...
  100. ncbi Comparison of near infrared and microwave resonance sensors for at-line moisture determination in powders and tablets
    Claudia C Corredor
    Analytical and Bioanalytical Development, Bristol Myers Squibb, New Brunswick, NJ 08901, United States
    Anal Chim Acta 696:84-93. 2011
    In this paper we demonstrate the feasibility of replacing KF for water content testing in bulk powders and tablets with at-line near infrared (NIR) or microwave resonance (MR) methods...
  101. ncbi Calcium phosphate apatites with variable Ca/P atomic ratio I. Synthesis, characterisation and thermal stability of powders
    S Raynaud
    Science des Procédés Céramiques et de Traitements de Surface, UMR 6638, Limoges, France
    Biomaterials 23:1065-72. 2002
    Single phased apatitic calcium phosphate powders Ca(10-x)(PO4)(6-x)(HPO4)x(OH)(2-x) with Ca/P molar ratio ranging from 1.5 to 1.667 (0 < or = x < or = 1) were synthesised using wet method...

Research Grants62

  1. Freeze-dried Fruit: Prevention and Rehabilitation Strategies in TBI
    Susan O McGuire; Fiscal Year: 2012
    ..we will test this hypothesis by examining the following specific aims: Objective 1: To test the effect of berry powders on clinical, histological, and inflammatory signs present in a rat model of TBI when berries are administered ..
  2. Stability and functionality of the Immunoject single-dose, auto-reconstitution de
    Brian Quinn; Fiscal Year: 2010
    ..to the parenteral delivery of the many pharmaceutical products that may now be formulated as rapidly dissolving powders. The unit-dose auto-reconstitution device is compact, relatively flat, and presents an economically attractive ..
  3. Schiff base forming sunscreen filters for long-wear UV protection
    Steven Isaacman; Fiscal Year: 2012
    ..The novel filters will be sold globally as powders and specialty dispersions, to be incorporated as long-wear ingredients in topical formulas...
  4. Near-Infrared VCD of Chiral Pharmaceuticals
    Laurence Nafie; Fiscal Year: 2004
    ..In addition to solution-phase sampling, we will investigate the use of mulls, pellets, powders, films and spin-coated samples...
  5. The effect of iron fortification of complementary foods on infant gut microbiota
    MICHAEL BRUCE ZIMMERMANN; Fiscal Year: 2011
    ..iron to this age group is a challenge, and in-home iron fortification of complementary foods using micronutrient powders is a promising approach...
  6. Delivery of Biological Therapeutics: Using Engineered Particles and Novel Deliver
    Joseph M DeSimone; Fiscal Year: 2013
    ..to evolve emerging top-down particle fabrication technologies to make 2-dimensional arrays and free flowing powders of shape specific micro- and nano-particles that are comprised of almost pure biological molecules...
  7. A new, rapidly dissolving and thermally stable dry powder Hepatitis-B vaccine
    STEPHEN P CAPE; Fiscal Year: 2013
    ..Our studies also showed that the dry micro-scale powders dissolved very rapidly, suggesting their utility in single dose auto-reconstitution devices aimed at parenteral ..
  8. Drug Interactions and Bioavailability of Cranberry
    Jennifer Donovan; Fiscal Year: 2005
    Cranberry (CB) juice and powders are currently being used as complementary and alternative medications...
  9. Totally Bioresorbable Drug-eluting Peripheral Polymer Stents
    HOCK SENG TAN; Fiscal Year: 2012
    ..CAD) based and has the capability to directly produce bioresorbable polymer stents by using polymer pellets and powders without any intermediate steps, such as making of polymer tubes and fibers...
  10. Protein Aggregation in Amorphous Solids
    Elizabeth M Topp; Fiscal Year: 2013
    ..While usually administered as solutions, many protein drugs are sold as amorphous solid powders, a form often chosen to preserve stability and prolong shelf-life...
  11. Delivery of Biological Therapeutics: Using Engineered Particles and Novel Deliver
    Joseph M DeSimone; Fiscal Year: 2011
    ..to evolve emerging top-down particle fabrication technologies to make 2-dimensional arrays and free flowing powders of shape specific micro- and nano-particles that are comprised of almost pure biological molecules...
  12. Are anthocyanins necessary for oral cancer chemoprevention by berries?
    CHRISTOPHER WEGHORST; Fiscal Year: 2009
    ..of polyphenols in fruit are primarily responsible for these activities?" Prior studies have employed lyophilized powders or extracts of ripe fruits containing a complex mixture of berry polyphenols of which a major group is the ..
  13. CARBON-13 MAGNETIC RESONANCE - METHODS AND THEORY
    DAVID MORRIS GRANT; Fiscal Year: 2010
    ..arrays, SSNMR focuses with greater accuracy on short range order especially when studying proton positions in powders. XRPD finds considerable success when Z = 1 and when the molecular weight is not overly high...
  14. Live, oral, heat Stable S. typhi TY21a vaccine
    ERIC PATZER; Fiscal Year: 2006
    ..Next, we will develop a process to produce powders from the solid foam that do not require refrigeration and are suitable for further processing for oral delivery...
  15. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    ..Submicrometer metal powders, with a large fraction of reactive surface area and good underground mobility, are ideally suited for this ..
  16. Allicin bioavailability of garlic products
    Larry Lawson; Fiscal Year: 2009
    ..Hence, garlic powders do not contain allicin...
  17. SEARCH FOR ULTRA FAST, HEAVY ATOM SCINTILLATORS
    STEPHEN DERENZO; Fiscal Year: 2006
    ..Candidate materials will be synthesized as powders or crystals and tested using our pulsed x-ray system and the same techniques used in the previous funding period...
  18. Pilot-Scale Libraries Based on Nucleoside Templates for the ML Initiative
    Robert C Reynolds; Fiscal Year: 2010
    ..highly pure and novel samples from the three specific aims and supply between 10 to 20 mg of each sample as dry powders to the MLSMR as per program requirements...
  19. Soluble Peracid Powders for Medical Device Disinfection
    G Hitchens; Fiscal Year: 2003
    ..These compounds can be synthesized and isolated as solid, concentrated powders with an extended shelf-life...
  20. Optical Ceramic Hafnates: New Fast PET Scintillator
    Charles Brecher; Fiscal Year: 2006
    ..All these properties will be improved by developing the proper procedures to synthesize the precursor powders and optimize the ceramic formation process...
  21. Nanostructured Zirconia Ceramics for Joint Prosthetics
    ANTHONY SUTORIK; Fiscal Year: 2004
    ..Tal Materials has learned to produce large quantities of very high quality nanosized 3YSZ powders using controlled energetic precursor technology (CONCEPT)...
  22. Development of ZnTe Powder Phosphor for Protein Crystallographic X-ray Detectors
    CHRISTOPHER SUMMERS; Fiscal Year: 2009
    ..Thus, in addition to higher efficiency, there is a strong motivation to produce ZnTe phosphor powders that can be used to make large screens for imaging the diffraction of protein crystals...
  23. OSTEOCLAST REGULATION & OSSEOINTEGRATION OF BIOIMPLANTS
    Peter Hauschka; Fiscal Year: 2002
    ..However, for the repair of large, critical-size defects with particulate hydroxyapatite, treated bone powders, and mineralized rigid implant (eg...
  24. High Performance Ultrasound Devise for Medical Imaging
    HAIXING ZHENG; Fiscal Year: 2007
    ..As a supplier for sol-gel precursors and nano powders, Chemat will production develop PZT fine powder and PZT nanocomposite thick film precursor and market sol-gel ..
  25. Plasma synthesized doped boron nanopowder for magnesium diboride superconductors
    JAMES MARZIK; Fiscal Year: 2007
    ..Initial experiments using plasma synthesis methods proved satisfactory to prepare carbon-doped boron powders suitable for the fabrication of high performance MgB2 conductors...
  26. Nanostructured Block-copolymer Reinforced Calcium Phosphate Composites
    LARA ESTROFF; Fiscal Year: 2009
    ..4) Development of self-hardening composites by mixing powders of the nanostructured composites developed in Aims 2 and 3 with an aqueous liquid phase to induce secondary ..
  27. DRY POWDER COATINGS FOR IMPROVED TUBERCULOSIS THERAPIES
    James Talton; Fiscal Year: 2000
    ..Nanosphere, Inc. proposes to apply a polymeric coating on dry powders using a recently developed Pulsed Laser Deposition (PLD) coating technique...
  28. PROTEIN BINDING SITES BY REDOR NMR
    Jacob Schaefer; Fiscal Year: 2002
    ..The applicant proposes to continue the development of REDOR methods using solid state NMR of lyophilized powders to describe ligand binding structures of large proteins...
  29. DEVELOPMENT & MANUFACTURE OF ORAL DOSAGE FORMS
    ROLLAND POUST; Fiscal Year: 2000
    ..be limited to tablets, enteric coated tablets, capsules, soft gelatin capsules, encapsulated granules and oral powders and solutions...
  30. FUNDAMENTAL FACTORS THAT AFFECT DUST GENERATION
    David Leith; Fiscal Year: 1990
    b>Powders and granulated solids are used throughout industry. Wherever these materials are handled, they generate dust that can affect worker health, cause a safety problem, or cause a nuisance...
  31. Manufacture and Supply of Hyperpolarized Chloroform for Use as an NMR Solvent
    NEAL KALECHOFSKY; Fiscal Year: 2009
    ..Produce high surface area frozen chloroform powders. II. Demonstrate that QRS may be used to produce polarizations of at least 1% in frozen powderized chloroform...
  32. Comparing Effects of 3 Sources of Garlic on Serum Lipids
    Christopher Gardner; Fiscal Year: 2005
    ..To date, the type of garlic preparation used in these clinical trials has predominantly been dried garlic powders. A few clinical trials have reported beneficial lipid effects using an aged garlic extract, and only a small ..
  33. High-Performance Transparent Optical Ceramic Scintillators through Nanotechnology
    ALEXANDER LEMPICKI; Fiscal Year: 2007
    ..We will establish techniques to fabricate the necessary nanoparticulate powders and to define the consolidation conditions under which the desired material properties can be achieved...
  34. Cloning, overexpression and characterization of novel alkene reductases
    Spiros Kambourakis; Fiscal Year: 2007
    ..applications, we have brought to the market more than 150 different enzymes formulated as active lyophilized powders, including transaminases, ketoreductases, nitrilases, amino acid dehydrogenases, aryl alcohol oxidases, human ..
  35. PZT/COMPOSITES FOR ULTRASOUND TRANSDUCERS
    XIAOXIN XIA; Fiscal Year: 1999
    ..PZT fibers (~20 um), and fine fibers will be mixed with various polymers to form (1-3) composites; (2) PZT powders will be roll or shear formed to thin PZT plates (<30 um) and mixed with polymers to form (2-2) laminate ..
  36. Slow Release Coatings for Inhaled Dynorphins
    Guenther Hochhaus; Fiscal Year: 2001
    ..Therefore drug powders will be coated with biodegradable polymers using a novel pulsed laser deposition based (PLD) coating technique to ..
  37. Characterization of Nano-Scale Pharmaceutical Powders *
    CRAIG SALTIEL; Fiscal Year: 2002
    ..to further develop and test Synergetic Technologies (Synergetics) novel system for characterizing pharmaceutical powders and their agglomerates...
  38. FABRICATING HIGH PERFORMANCE PROSTHESES
    RAMAS RAMAN; Fiscal Year: 1991
    ..The benefitsof recently developed powders metal consolidaion process (Ceracon) to form ultrafine-grained near net shape hip implant material will be ..
  39. DEVELOPING DIGESTIZYME MICROSPHERES IN CYSTIC FIBROSIS
    Tibor Sipos; Fiscal Year: 1991
    ..Investigate the compatibility and stability of high potency pancreatic enzyme powders, purchased from different manufacturers, for compatibility with bile acids and other formulation ingredients. 2...
  40. REGULATION OF MYOCARDIAL LIPOLYSIS
    WARREN PALMER; Fiscal Year: 1990
    ..This activation occurs regardless of whether measurements are made on aqueous homogenates or on delipidated heart powders. The enzyme activity was highly correlated with the amount of TG reduction that occurred in the heart...
  41. UNIQUE, SMALL PARTICLE PHOSPHOR POWDERS FOR IMUNOASSAYS
    MARK HAMPDEN SMITH; Fiscal Year: 2000
    ..Superior MicroPowders (SMP) teamed with STC Technologies proposes to develop new phosphor powders for use in phosphorescent immunoassays (PIAs)...
  42. Submicron Particles and Fibers for Toxicological Studies
    Gustavo Larsen; Fiscal Year: 2006
    ..venture is based on a unique set of manufacturing methods to design a wide variety of well-defined nanostructured powders, and a partnership with the Midwest Research Institute is established to integrate toxicology tests with the ..
  43. SOLVENT AND SMALL SOLUTES IN TISSUES AND PROTEINS
    Robert Bryant; Fiscal Year: 1980
    ..relaxation measurements on protons, deuterium, carbon, and other rare spin nuclei in protein crystals, protein powders and protein solutions which will directly define the state of water in protein systems as fundamental background ..
  44. REUSABLE STORAGE PHOSPHOR FOR ADVANCED RADIATION THERAPY DOSIMETRY
    Hui Li; Fiscal Year: 2009
    ..Our first aim is to develop a process for preparing low Z storage phosphor powders. Our second aim is to quantify the dosimetric properties and optimize the phosphor production process developed ..
  45. Methamphetamine Use and HIV Risk in Homosexuals
    Michael Clatts; Fiscal Year: 2003
    ..use of "Speed" is prevalent among MSM; 2) To describe the range of forms of "Speed" used by MSM, including pills, powders, "rock," and "crystal," and variability in the modes of administration that are associated with these different ..
  46. Prion Inactivation in Human Plasma Derived Products
    William Drohan; Fiscal Year: 2003
    ..This process is applicable to solutions, liquid or frozen, powders, and pastes, making it amenable to incorporation into manufacturing processes...
  47. Lu hafnate optical ceramic: a new fast PET scintillator
    ALEXANDER LEMPICKI; Fiscal Year: 2003
    ..All these properties will be improved by developing the proper procedures to synthesize the precursor powders and optimize the ceramic formation process...
  48. Inhalable IgG Synthesis For Influenza Immunoprophylaxis
    STEPHEN CAPE; Fiscal Year: 2004
    ..Development of stable antibody powders with high surface areas that can be stored for months at room temperature in the field without refrigeration and ..
  49. SEARCH FOR ULTRA FAST, HEAVY ATOM SCINTILLATORS
    STEPHEN DERENZO; Fiscal Year: 2001
    ..Candidate materials will be synthesized as powders and tested using our pulsed x-ray system.
  50. Nanoparticle Generator for Animal Inhalation Experiments
    Amir Naqwi; Fiscal Year: 2005
    ..Future applications of this technology would include generation of nano-powders of drugs for the purpose of efficient delivery and high bioavailability, as well as fluorescent nanoprobes for ..
  51. ON-BOARD DIAGNOSTIC SENSOR FOR RESPIRATOR BREAKTHROUGH
    DEBRA DEININGER; Fiscal Year: 2003
    ..the Phase I that it is feasible to use novel materials selection (including polymers and nano-scale ceramic powders) to overcome present limitations of solid state sensor technology including: high operating temperature (300-400 ..
  52. MANUFACTURE OF NANO-ENGINEERED DENTAL BIOMATERIALS
    ROGER DIRSTINE; Fiscal Year: 2000
    ..Conventional methods of producing powders, such as spray drying, milling or lyophilization, have serious limitations...
  53. HYDROTHERMAL SYNTHESIS OF HYDOXYAPATITE POWDER
    RICHARD RIMAN; Fiscal Year: 2000
    ..hydrothermal synthesis methods for the preparation of "ideal" phase-pure nonstoichiometric hydroxyapatite powders, with controlled CO32- and HPO42- content and submicron, equiaxed, monodisperse and unagglomerated particles...
  54. INTERFACIAL BEHAVIOR OF BIOMATERIALS
    Larry Hench; Fiscal Year: 1980
    ..In eight different toxicity test systems Bioglasses in the form of solid discs, fibers, or powders exhibited no detectable toxicity but provides a surface compatible with cell adhesion and proliferation...
  55. ON-BOARD DIAGNOSTIC SENSOR FOR RESPIRATOR BREAKTHROUGH
    BIJAN MIREMADI; Fiscal Year: 2000
    ..Superior Solutions will use novel materials selection (including polymers and nano-scale ceramic powders) in order to overcome present limitations of solid state sensor technology including: high operating temperature (..
  56. CROSS POLARIZATION NMR OF RARE SPINS IN PROTEIN SYSTEMS
    Robert Bryant; Fiscal Year: 1980
    ..It will investigate side chain motion in protein crystals, motion in protein powders, as a function of hydration, motion and structure in protein gels, structure and dynamics in frozen protein ..
  57. MECHANISMS OF RESPONSE TO PULMONARY VACCINATION
    Anthony Hickey; Fiscal Year: 2005
    ..The significance of this work lies in the novelty of pulmonary vaccination for the treatment of tuberculosis and the knowledge of the immune response gained from targeted antigen delivery to the lungs. ..
  58. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  59. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  60. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  61. PHYSICOCHEMICAL MODIFICATIONS OF DENTAL RESTORATIVES
    Samuel Stupp; Fiscal Year: 1980
    ..for this project includes the preparation of charged silaceous fillers for enhancement of wear resistance and the synthesis of ionizable copolymers to increase the electrostatic strength of polarization carriers in polymeric powders.
  62. The role of selenoproteins in the etiology of cancer
    Philip Moos; Fiscal Year: 2008
    ..Does SelP have a novel function in the regulation of lipid hydroperoxides? These studies provide an integrated framework to understand how electrophiles and selenium/selenoproteins contribute to the etiology of cancer. ..