Genomes and Genes
Summary: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.
Publications232 found, 100 shown here
- 0.3% Tacrolimus gel and 0.5% Tacrolimus cream show efficacy in mild to moderate plaque psoriasis: Results of a randomized, open-label, observer-blinded studyJean Paul Ortonne
Service de Dermatologie, Hopital Archet 2, Nice, France
Acta Derm Venereol 86:29-33. 2006..011). Skin burning was mostly mild in intensity and decreased substantially after 1 week of treatment. There were no differences in the nature and incidence of infections and no clinically relevant changes in laboratory values...
- Steroid-sparing effect of pimecrolimus cream 1% in children with severe atopic dermatitisTorsten Zuberbier
Department of Dermatology and Allergy, Allergy Centre Charité, Berlin, Germany
Dermatology 215:325-30. 2007..To investigate if pimecrolimus cream 1% reduces the need for steroids in the long-term management of severe pediatric atopic dermatitis (AD)...
- Moist Exposed Burn Ointment (MEBO) in partial thickness burns - a randomized, comparative open mono-center study on the efficacy of dermaheal (MEBO) ointment on thermal 2nd degree burns compared to conventional therapyT Hirsch
Department of Plastic, and Reconstructive Surgery, HELIOS Klinikum Wuppertal, University of Witten Herdecke, Germany
Eur J Med Res 13:505-10. 2008..The purpose of this study was to evaluate the efficacy of a new therapeutic ointment (MEBO) in the treatment of partial thickness burns...
- Cytotoxicity testing of burn wound dressings, ointments and creams: a method using polycarbonate cell culture inserts on a cell culture systemMargit Kempf
Centre for Children s Burns and Trauma Research, The University of Queensland, Department of Paediatrics and Child Health and Queensland Children s Medical Research Institute, Level 4, Foundation Building, Royal Children s Hospital, Brisbane, QLD 4029, Australia
Burns 37:994-1000. 2011We have developed a method to test the cytotoxicity of wound dressings, ointments, creams and gels used in our Burn Centre, by placing them on a permeable Nunc™ Polycarbonate cell culture insert, incubated with a monolayer of cells (..
- An in vitro biofilm model to examine the effect of antibiotic ointments on biofilms produced by burn wound bacterial isolatesAdrienne A Hammond
Department of Surgery, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA
Burns 37:312-21. 2011..Yet, a simple in vitro assay to compare the susceptibility of biofilms produced by burn wound isolates to different topical antibiotics has not been reported...
- Exploring the wound healing activity of Arnebia densiflora (Nordm.) Ledeb. by in vivo modelsEsra Küpeli Akkol
Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Etiler 06330, Ankara, Turkey
J Ethnopharmacol 124:137-41. 2009..Ledeb. (Boraginaceae), which is an endemic plant for Turkey, have been used for healing of wounds in folk medicine. The extract of the roots in olive oil and mostly the root barks was applied onto open wounds for rapid healing...
- [Dexpanthenol nasal spray in comparison to dexpanthenol nasal ointment. A prospective, randomised, open, cross-over study to compare nasal mucociliary clearance]T Verse
Universitäts Hals Nasen Ohren Klinik Mannheim
HNO 52:611-5. 2004..The main outcome measure was in vivo mucociliary clearance...
- Randomized, controlled, double-blind trial of topical treatment of cutaneous leishmaniasis with paromomycin plus methylbenzethonium chloride ointment in GuatemalaB A Arana
Center for Health Studies, Universidad del Valle de Guatemala, Guatemala
Am J Trop Med Hyg 65:466-70. 2001..Our findings show that the combination of paromomycin with methylbenzethonium chloride for 20 days is a good alternative for antimonial treatments of cutaneous leishmaniasis in Guatemala...
- Characterization of vernix caseosa as a natural biofilm: comparison to standard oil-based ointmentsM I Bautista
Skin Sciences Institute, Children s Hospital Research Foundation, University of Cincinnati, Cincinnati, Ohio 45267 0541, USA
Pediatr Dermatol 17:253-60. 2000The application of occlusive films and oil-in-oil ointments has been reported to improve epidermal barrier function in very low birthweight, preterm infants...
- An investigator-masked comparison of the efficacy and safety of twice daily applications of calcitriol 3 microg/g ointment vs. calcipotriol 50 microg/g ointment in subjects with mild to moderate chronic plaque-type psoriasisX Zhu
Department of Dermatology, Peking University First Hospital, Beijing, China
J Eur Acad Dermatol Venereol 21:466-72. 2007..Calcitriol and calcipotriol, two vitamin D derivatives, are available for topical treatment of psoriasis and have been shown to be effective...
- Cutaneous resorption of lead after external use of lead-containing ointments in volunteers with healthy skinRobert W Gorter
International Institute for Oncological and Immunological Research, Hohenstaufenring 30 32, 50674 Cologne, Germany
Am J Ther 12:17-21. 2005Lead-containing ointments are frequently used in anthroposophic medicine...
- The influence of dressings and ointments on the qualitative and quantitative evaluation of burn wounds by ICG video-angiography: an experimental setupW Haslik
Department of Surgery, Division of Plastic and Reconstructive Surgery, Medical School, University of Vienna, Waehringer Guertel 18 20, Vienna 1090, Austria
Burns 30:232-5. 2004..Since burn wounds are often covered with dressings and ointments or soiled with blood, it is necessary to evaluate the influence of these substances on ICG video-angiography and ..
- Comparative transcutaneous immunization with imiquimod-containing ointments and potential of in vitro methods to predict effectsKarsten Gogoll
Biopharmaceutics and Pharmaceutical Technology, Johannes Gutenberg University, Mainz, Germany
Biopharm Drug Dispos 33:218-28. 2012..421 and 0.669). Yet this correlation is deemed not satisfactory for formulation optimization...
- [Antibiotic ointments and methicillin-resistant Staphylococcus aureus with a reservoir in a healthcare worker in a tertiary hospital]Jesús Molina-Cabrillana
Servicio de Medicina Preventiva, Complejo Hospitalario Universitario Insular Materno Infantil CHUIMI, Las Palmas de Gran Canaria, España Electronic address
Enferm Infecc Microbiol Clin 31:511-5. 2013....
- Treatment of erosive oral lichen planus with topical tacrolimusM A Thomson
Department of Dermatology, Selly Oak Hospital, Birmingham, UK
J Dermatolog Treat 15:308-14. 2004..Erosive oral lichen planus (LP) is a painful chronic inflammatory condition that is frequently resistant to immunosuppressive agents. Topical tacrolimus has been reported as a safe and effective treatment...
- Tacrolimus ointment for the treatment of vulvar lichen sclerosusTill Assmann
Department of Dermatology, Heinrich Heine University, Duesseldorf, Germany
J Am Acad Dermatol 48:935-7. 2003..1% (Protopic) twice daily, signs and symptoms of lichen sclerosus resolved. To our knowledge, this is the first report of the use of topical tacrolimus, which does not induce skin atrophy, in the treatment of vulvar lichen sclerosus...
- Tacrolimus ointment 0.1% in the treatment of allergic contact eyelid dermatitisA Katsarou
Department of Dermatology, University of Athens, A Sygros Hospital, Athens, Greece
J Eur Acad Dermatol Venereol 23:382-7. 2009..The safety profile of tacrolimus makes it a promising therapeutic option for dermatitis affecting the delicate periorbital skin...
- Successful treatment of vulvar lichen sclerosus with topical tacrolimusRainer Kunstfeld
University of Vienna Medical School, Vienna, Austria
Arch Dermatol 139:850-2. 2003
- Tacrolimus ointment in the treatment of chronic cutaneous graft-vs-host disease: a case series of 18 patientsC J Choi
Department of Dermatology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Harvard Medical School, Boston, Mass, USA
Arch Dermatol 137:1202-6. 2001..The rapid response of tacrolimus ointment may provide a useful therapeutic bridge to systemic therapies that have slower onset, such as psoralen-UV-A therapy or extracorporeal photopheresis...
- Topical tacrolimus--a novel treatment alternative for cutaneous chronic graft-versus-host diseaseSharon Elad
Hospital Oral Medicine Department, Hadassah University Hospital, Jerusalem, Israel
Transpl Int 16:665-70. 2003..Topical tacrolimus is suggested as an alternative treatment for cutaneous chronic steroid-dependent GVHD. This conclusion concurs with a previous study on this medication...
- Tacrolimus ointment: the treatment of atopic dermatitis and other inflammatory cutaneous diseaseChristie L Carroll
Department of Dematology, Wake Forest University School of Medicine, Wiston Salem, North Carolina 27157 1071, USA
Expert Opin Pharmacother 5:2127-37. 2004..Overall, tacrolimus has proven to be a safe and useful topical therapy for many inflammatory dermatological conditions, with AD being the principal indication...
- Successful treatment of anogenital lichen sclerosus with topical tacrolimusMarkus Bohm
Department of Dermatology, University of Munster, Munster, Germany
Arch Dermatol 139:922-4. 2003..Lichen sclerosus of the anogenital area is a chronic inflammatory and fibrosclerotic disease associated with substantial morbidity. Topical ultrapotent corticosteroids are currently the treatment of choice...
- Benefit-cost analysis of moist exposed burn ointmentBishara S Atiyeh
Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Burns 28:659-63. 2002....
- Topical anesthetics update: EMLA and beyondP M Friedman
Derm Surgery Associates, Houston, Texas 77030, USA
Dermatol Surg 27:1019-26. 2001..EMLA is the most commonly used agent, however, several new topical anesthetic agents have been released recently that claim increased efficacy and a faster onset of action...
- A homeopathic ointment preparation compared with 1% diclofenac gel for acute symptomatic treatment of tendinopathyChristian Schneider
Klinik für Ganzheitsmedizin, Herrsching, Germany
Explore (NY) 1:446-52. 2005..The incidence of tendon injuries and tendinopathy has risen substantially in the past decades...
- The influence of a eutectic mixture of lidocaine and prilocaine on minor surgical procedures: a randomized controlled double-blind trialFaisal M Shaikh
Department of Surgery, Mid Western Regional Hospital, Limerick, Ireland
Dermatol Surg 35:948-51. 2009..A eutectic mixture of lidocaine and prilocaine (EMLA) has been shown to be effective in reducing pain from needle sticks, including those associated with blood sampling and intravenous insertion...
- Antimicrobial ointments and methicillin-resistant Staphylococcus aureus USA300Masahiro Suzuki
Aichi Prefectural Institute of Public Health, Nagoya, Japan
Emerg Infect Dis 17:1917-20. 2011..ATCC type strains for susceptibility to bacitracin and neomycin contained in over-the-counter antibacterial ointments. Resistance to both bacitracin and neomycin was found only in USA300...
- A 4-year follow-up study of atopic dermatitis therapy with 0.1% tacrolimus ointment in children and adult patientsS Reitamo
Department of Dermatology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki, Finland
Br J Dermatol 159:942-51. 2008..For the treatment of a chronic disease like atopic dermatitis, sustained tolerability and efficacy of the applied medication are essential...
- [A comparison between "moist ointment" and 0.25% iodophor, silver sulfadiazine paste and 0.1% rivanol in the treatment of deep II degree burn wounds]Y Li
Department of Surgery, Shougang General Hospital, Beijing
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi 10:342-5. 1994..Therefore, we suggested that the use of moist ointment in the treatment of deep II degree burn wound should be prohibited...
- Scar quality and physiologic barrier function restoration after moist and moist-exposed dressings of partial-thickness woundsBishara S Atiyeh
Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Dermatol Surg 29:14-20. 2003....
- Efficacy of moist exposed burn ointment in the management of cutaneous wounds and ulcers: a multicenter pilot studyBishara S Atiyeh
Ann Plast Surg 48:226-7. 2002
- Comparison between Alpha and silver sulfadiazine ointments in treatment of Pseudomonas infections in 3rd degree burnsSeyed V Hosseini
Gastroenterohepatology Research Center, Department of Surgery, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
Int J Surg 5:23-6. 2007..Alpha ointment is a less expensive drug with an acceptable result compared to SS. Therefore, we recommend it as an alternative to SS, especially in patients with low economical backgrounds or in those who show adverse reactions to SS...
- Improved scar quality following primary and secondary healing of cutaneous woundsBishara S Atiyeh
American University of Beirut, Beirut, Lebanon
Aesthetic Plast Surg 27:411-7. 2003..Statistical analysis revealed that for both types of wound healing, scar quality was significantly superior in those wounds treated with MEBO...
- In vitro delivery of novel, highly potent anti-varicella zoster virus nucleoside analogues to their target site in the skinChris A Jarvis
Welsh School of Pharmacy, Cardiff University, Cardiff, CF10 3XF, UK
Pharm Res 21:914-9. 2004..To determine the in-vitro dermal delivery of a new class of lipophilic, highly potent and uniquely selective anti-VZV nucleoside analogues in comparison with aciclovir...
- Examination of the cutaneous absorption of copper after the use of copper-containing ointmentsRobert W Gorter
International Institute for Oncological and Immunological Research, Cologne, Germany
Am J Ther 11:453-8. 2004Because copper-containing ointments are frequently used in anthroposophical medicine, a phase I trial to investigate the cutaneous absorption of copper was conducted. Sixty-one volunteers were randomized [group A: 0...
- Efficacy of paromomycin ointment in the treatment of cutaneous leishmaniasis: results of a double-blind, randomized trial in Isfahan, IranF Iraji
Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran
Ann Trop Med Parasitol 99:3-9. 2005..Ointment containing 15% paromomycin therefore appears ineffective in the treatment of CL, at least when applied twice daily for 30 days to the lesions of cases from an endemic area of Isfahan, Iran...
- In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetryMilan Petelin
Department of Oral Medicine and Periodontology, Faculty of Medicine, University of Ljubljana, Hrvatski trg 6, Ljubljana 1000, Slovenia
Int J Pharm 270:83-91. 2004..was to determine the rate of transport and long-term effect of a drug applied to the oral mucosa in different ointments. Three ointments with bioadhesive properties: Orabase, Carbopol 935P, and polymethyl methacrylate (PMM) and the ..
- Effects of metronidazole and tinidazole ointments on models for inflammatory dermatitis in miceK Nishimuta
Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
Arch Dermatol Res 294:544-51. 2003We investigated the effects of 1-4% ointments of metronidazole and tinidazole (derivatives of nitroimidazole) on models of inflammatory dermatitis evoked by antigen, hapten and monoclonal anti-dinitrophenol (DNP) IgE antibody in mice...
- [Bibrocathol eye ointment is efficacious in blepharitis. Results from a randomized, double-blind, controlled clinical trial]W Behrens-Baumann
Universitätsaugenklinik Magdeburg, Leipziger Strasse 44, Haus 60b, 39120 Magdeburg, Germany
Ophthalmologe 103:960-5. 2006..Bibrocathol treatment is well tolerated and safe...
- Effect of 0.03% tacrolimus ointment on conjunctival cytology in patients with severe atopic blepharoconjunctivitis: a retrospective studyHannele M Virtanen
Department of Dermatology, Hospital for Skin and Allergic Diseases, Helsinki University Central Hospital, Helsinki, Finland
Acta Ophthalmol Scand 84:693-5. 2006..To evaluate the efficacy and effect of tacrolimus ointment on conjunctival cytology in patients with atopic blepharoconjunctivitis or keratoconjunctivitis...
- Long-term use of topical tacrolimus (FK506) in high-risk penetrating keratoplastyJasmeet S Dhaliwal
Henry Ford Health System, Ophthalmology, Troy, MI, USA
Cornea 27:488-93. 2008..To evaluate the long-term efficacy and side effects of off-label topical tacrolimus 0.03% ointment (Protopic; Fujisawa Health, Deerfield, IL) as a sole second-line immunosuppressive agent in the management of high-risk corneal grafts...
- Clobetasol propionate for psoriasis: are ointments really more potent?Lindsey Warino
Ohio State University College of Medicine, School of Public Health, Columbus, OH, USA
J Drugs Dermatol 5:527-32. 2006..We excluded studies conducted before 1980 and those that allowed concomitant treatments...
- Depth of cutaneous analgesia after application of a eutectic mixture of the local anesthetics lidocaine and prilocaine (EMLA cream)C F Wahlgren
Department of Dermatology, Karolinska Hospital and Institute, Stockholm, Sweden
J Am Acad Dermatol 42:584-8. 2000..EMLA cream, a eutectic mixture of lidocaine and prilocaine, is a topical anesthetic, frequently used to avoid pain during venipuncture and superficial surgery. However, the depth of analgesia needs further exploration...
- Biopharmaceutical availability of sulphadicramide from ocular ointments in vitroE Grzeskowiak
Department of Physical Chemistry, K Marcinkowski University of Medical Sciences, Poznan, Poland
Eur J Pharm Sci 6:247-53. 1998..Formulation of ophthalmic ointments containing sulphadicramide and the above promoters was proposed and biopharmaceutical evaluation of the ..
- Tacrolimus ointment for the treatment of atopic dermatitis in adult patients: part II, safetyN A Soter
New York University School of Medicine, Department of Dermatology, NY 10016 6451, USA
J Am Acad Dermatol 44:S39-46. 2001..Tacrolimus ointment is a safe therapy for the treatment of adult patients with atopic dermatitis on the face, neck, or other body regions...
- Topical tacrolimus ointment for treatment of refractory anterior segment inflammatory disordersMark A Joseph
West Virginia University, WVU Eye Institute, Morgantown, USA
Cornea 24:417-20. 2005..To report 4 cases of patients treated with topical tacrolimus ointment 0.03% for ocular inflammatory conditions refractory to traditional treatment...
- Efficacy of moist exposed burn ointment on burnsHong Qi Zhang
School of Chinese Medicine, Hong Kong Baptist University, Hong Kong
J Burn Care Rehabil 26:247-51. 2005..05), either in terms of wound healing rate or bacterial control. We conclude that the MEBO is not suitable for deep burn wound treatment, particularly when infection is a concern...
- Moist exposed therapy: an effective and valid alternative to occlusive dressings for postlaser resurfacing wound careBishara S Atiyeh
Division of Plastic and Reconstructive Surgery, American University of Beirut Medical Center, Beirut, Lebanon
Dermatol Surg 30:18-25; discussion 25. 2004..Occlusive moisture-retentive dressings, however, are difficult to apply and maintain in position and may as well be complicated by serious infections...
- Therapeutic effects of tacrolimus ointment for refractory ocular surface inflammatory diseasesDai Miyazaki
Division of Ophthalmology and Visual Science, Tottori University Medical School, Yonago, Japan
Ophthalmology 115:988-992.e5. 2008..To investigate the therapeutic effects of topical tacrolimus ointment on refractory ocular surface inflammatory diseases...
- Topical application with a new NF-kappaB inhibitor improves atopic dermatitis in NC/NgaTnd miceAkane Tanaka
Laboratory of Veterinary Molecular Pathology and Therapeutics, Division of Animal Life Science, Graduate School, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Tokyo, Japan
J Invest Dermatol 127:855-63. 2007..IMD-0354 effectively reduced the allergic inflammation in NC/NgaTnd mice in vivo. Thus, a drug that interferes with NF-kappaB activity may provide an alternative therapeutic strategy for the treatment of AD...
- Comparison of topical tacrolimus 0.1 % in pectin ointment with clobetasol 0.5% ointment in adults with moderate to severe desquamative gingivitis: A 4-week, randomized, double-blind clinical trialGiovanni Corrocher
Dipartimento di Scienze Morfologico Biomediche, Sezione di Chirurgia Maxillo Facciale e Odontostomatologia, Universita di Verona, Verona, Italy
Clin Ther 28:1296-302. 2006..The time from the development of initial signs of DG to diagnosis can vary from months to years. Based on a literature search, no data concerning patients with DG without signs of autoimmune disease were available...
- Effects of tacrolimus ointment on facial eruption, itch, and scratching in patients with atopic dermatitisNorito Katoh
Department of Dermatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan
J Dermatol 31:194-9. 2004..This suggests that tacrolimus ointment is effective for the itch and scratching in cases where degrees might be discrepant from the severity of eruptions in patients with recalcitrant facial eruptions of AD...
- A double-blind, randomized quantitative comparison of calcitriol ointment and calcipotriol ointment on epidermal cell populations, proliferation and differentiationJ E M Körver
Department of Dermatology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
Br J Dermatol 156:130-7. 2007..However, studies comparing both treatment modalities are scarce. Especially, there are almost no studies comparing the effects on epidermal cell populations in a quantitative manner...
- Efficacy and safety of tacrolimus ointment in pediatric Patients with moderate to severe atopic dermatitisSrisuphaluk Singalavanija
Dermatology Unit, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand
J Med Assoc Thai 89:1915-22. 2006..They often require systemic steroids, which may result in growth retardation. Protopic, a non-steroid, tacrolimus based ointment which is a calcinurin inhibitor has been proved to be effective in caucacian with AD...
- Tacrolimus ointment 0.03% is safe and effective for the treatment of mild to moderate atopic dermatitis in pediatric patients: results from a randomized, double-blind, vehicle-controlled studyLawrence A Schachner
Division of Dermatology and Cutaneous Surgery, University of Miami, Miami, Florida, USA
Pediatrics 116:e334-42. 2005..This study was designed to compare the safety and efficacy of tacrolimus ointment 0.03% with vehicle ointment for the treatment of mild to moderate atopic dermatitis (AD) in pediatric patients...
- Pimecrolimus and narrowband UVB as monotherapy or combination therapy in children and adolescents with atopic dermatitisTien Yi Tzung
Department of Dermatology, Veterans General Hospital Kaohsiung, Kaohsiung, Taiwan
Acta Derm Venereol 86:34-8. 2006..In conclusion, because of the lack of short-term additive therapeutic efficacy, concomitant use of pimecrolimus and narrowband UVB is inadvisable in treating moderate to severe atopic dermatitis in children and adolescents...
- Long-term safety and efficacy of tacrolimus ointment for the treatment of atopic dermatitis in childrenAnita Remitz
Department of Dermatology, Helsinki University Central Hospital, Meilahdentie 2, Helsinki, Finland
Acta Derm Venereol 87:54-61. 2007..Substantial improvement in all efficacy end-points was observed by week 2 and maintained throughout the study. Long-term treatment with tacrolimus ointment is safe and effective in these patients with atopic dermatitis...
- Tacrolimus ointment in the treatment of eyelid dermatitisAmy Krupnick Freeman
Department of Dermatology, Mount Sinai School of Medicine, New York, New York, USA
Cutis 73:267-71. 2004..In addition, none of the patients developed cataracts or glaucoma during the study. In summary, tacrolimus ointment 0.1% may be a safe and effective treatment option for patients with moderate to severe eyelid dermatitis...
- [Local treatment of atopic dermatitis with calcineurin inhibitors]Tor Langeland
Tidsskr Nor Laegeforen 126:321-2. 2006
- Molluscum contagiosum in atopic dermatitis treated with 0.1% tacrolimus ointmentLeah M Wilson
Department of Dermatology, Flinders Medical Centre, Royal Adelaide Hospital, South Australia, Australia
Australas J Dermatol 45:184-5. 2004..Of particular note, these lesions remained confined to areas treated with tacrolimus and did not extend to adjacent regions treated with topical corticosteroids...
- The role of topical calcineurin inhibitors in atopic dermatitisA Alomar
Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Spain
Br J Dermatol 151:3-27. 2004..In addition, this review summarizes findings from the many trials carried out with these agents and outlines how TCIs can provide long-term treatment and control of a chronic skin disease that may persist for years...
- Treatment of localized lesions of canine atopic dermatitis with tacrolimus ointment: a blinded randomized controlled trialEmmanuel Bensignor
Dermatology Unit, Veterinary Clinic, 75003 Paris and 35510 Cesson Sévigné, France
Vet Dermatol 16:52-60. 2005..Results of this trial suggest that the application of 0.1% tacrolimus ointment is useful for reducing the severity of localized skin lesions of canine AD...
- Efficacy and tolerability of topical pimecrolimus and tacrolimus in the treatment of atopic dermatitis: meta-analysis of randomised controlled trialsDarren M Ashcroft
School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL
BMJ 330:516. 2005..To determine the efficacy and tolerability of topical pimecrolimus and tacrolimus compared with other treatments for atopic dermatitis...
- Influence of pimecrolimus cream 1% on different morphological signs of eczema in infants with atopic dermatitisKristine Breuer
Department of Dermatology and Allergology, Hannover Medical University, Germany
Dermatology 209:314-20. 2004..In the published studies on the efficacy of the topical immunomodulator pimecrolimus, different eczema scores were used, and the impact on morphological key signs of eczema was not analysed...
- Topical 0.05% clobetasol propionate versus 1% pimecrolimus ointment in vitiligoBasak Coskun
Firat University Faculty of Medicine, Department of Dermatology, Elazig Turkey
Eur J Dermatol 15:88-91. 2005..For a better conclusive statement further studies involving larger groups of patients should be performed...
- Pimecrolimus cream 1% in the treatment of intertriginous psoriasis: a double-blind, randomized studyCarin Gribetz
Mt Sinai School of Medicine, Department of Dermatology, New York, New York, USA
J Am Acad Dermatol 51:731-8. 2004..Pimecrolimus, a well-tolerated, nonatrophogenic, skin-selective inflammatory cytokine inhibitor, has been shown to be effective in the treatment of psoriasis when applied topically under occlusion...
- Investigation on the clinical efficacy and safety of 0.1% tacrolimus ointment (Protopic) in canine atopic dermatitis: a randomized, double-blinded, placebo-controlled, cross-over studyR Marsella
Blanche Saunders Dermatology Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, P O Box 100126, Gainesville, FL 32610 0126, USA
Vet Dermatol 15:294-303. 2004..In conclusion, tacrolimus appears to be a safe alternative treatment in dogs with atopic dermatitis, especially in those with localized disease...
- [Topical immunomodulators, such as tacrolimus and pimecrolimus, in the treatment of atopic dermatitis]M S de Bruin-Weller
Universitair Medisch Centrum Utrecht, afd Dermatologie Allergologie, Heidelberglaan 100, 3584 CX Utrecht
Ned Tijdschr Geneeskd 149:1096-100. 2005..For patients with severe atopic dermatitis, the addition of TIMs to oral immunosuppressive drugs, such as cyclosporin, may allow for dose reductions of oral medication...
- A novel foam vehicle for delivery of topical corticosteroidsXinfan Huang
Center for Skin Biology, Connetics Corp, Palo Alto, California 94303, USA
J Am Acad Dermatol 53:S26-38. 2005..The latter mechanism reflects a hydration-dependent process, which may result in comparatively slower drug permeation...
- Topical pimecrolimus 1% for the treatment of pruritic external auditory canalsHamid R Djalilian
University of Illinois at Chicago and Academic Dermatology and Skin Cancer Institute, Chicago, Illinois, USA
Laryngoscope 116:1809-12. 2006..To understand the role and efficacy of topical pimecrolimus in the treatment of refractory pruritus of the external auditory canals (EACs)...
- Immunomodulation and safety of topical calcineurin inhibitors for the treatment of atopic dermatitisThomas Hultsch
Novartis Pharmaceuticals Corporation, East Hanover, NJ 0793 1080, USA
Dermatology 211:174-87. 2005..g., tacrolimus, cyclosporine A, and corticosteroids) in transplant patients. Preclinical and clinical data suggest a greater skin selectivity and larger safety margin for topical pimecrolimus...
- Safety and efficacy of tacrolimus ointment 0.1% (Protopic) in atopic dermatitis: a Canadian open-label multicenter studyJerry Tan
Department of Medicine, University of Western Ontario, Windsor, Ontario, Canada
J Cutan Med Surg 8:213-9. 2004..Most previously published trials of topical tacrolimus in atopic dermatitis were of relatively short duration and comprised a limited population with moderate-to-severe disease...
- A randomized study of the safety, absorption and efficacy of pimecrolimus cream 1% applied twice or four times daily in patients with atopic dermatitisMark Ling
MedaPhase Inc, Newman, GA 30263, USA
J Dermatolog Treat 16:142-8. 2005..This study compared the safety, efficacy and systemic absorption of pimecrolimus administered twice daily (recommended dose) and four times daily early in the treatment of patients with moderate to severe atopic dermatitis...
- The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical studyM Caproni
Department of Dermatological Sciences, University of Florence, Via della Pergola 58 60, 50121 Florence, Italy
Br J Dermatol 156:312-9. 2007....
- Non-melanoma skin cancer in patients with atopic dermatitis treated with topical tacrolimusMark Naylor
Oklahoma University Health Science Center, Deerfield, IL 60015, USA
J Dermatolog Treat 16:149-53. 2005..To determine whether atopic dermatitis (AD) patients treated with tacrolimus ointment experienced an increased risk of non-melanoma skin cancer (NMSC)...
- Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: a double-blind, randomized, right-left comparison studyJoe S Angelo
Department of Dermatology, SLR and TC, Karigiri, Vellore, India
Indian J Dermatol Venereol Leprol 73:65. 2007..No controlled data is available till date comparing topical tazarotene and clobetasol in Indian psoriatic patients...
- Efficacy and safety of tacrolimus ointment compared with that of hydrocortisone butyrate ointment in adult patients with atopic dermatitisSakari Reitamo
Department of Dermatology, Hospital for Skin and Allergic Diseases, University of Helsinki, Helsinki, Finland
J Allergy Clin Immunol 109:547-55. 2002..Vehicle-controlled studies have demonstrated the efficacy and safety of tacrolimus ointment for patients with atopic dermatitis...
- Cost-effectiveness analysis of tacrolimus ointment versus high-potency topical corticosteroids in adults with moderate to severe atopic dermatitisCharles N Ellis
Department of Dermatology, University of Michigan Medical School, Ann Arbor 48109 0314, USA
J Am Acad Dermatol 48:553-63. 2003..Few cost-effectiveness analyses have been conducted on topical therapies for atopic dermatitis...
- Safety and efficacy of nonsteroid pimecrolimus cream 1% in the treatment of atopic dermatitis in infantsVincent C Ho
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Pediatr 142:155-62. 2003..The safety and efficacy of a 1% cream formulation of pimecrolimus, a selective, nonsteroid immunomodulator, was studied in infants with atopic dermatitis (AD)...
- A randomized controlled trial of pimecrolimus cream 1% in adolescents and adults with head and neck atopic dermatitis and intolerant of, or dependent on, topical corticosteroidsD F Murrell
Department of Dermatology, St George Hospital, University of NSW, Sydney, Australia
Br J Dermatol 157:954-9. 2007....
- Pimecrolimus cream in the long-term management of atopic dermatitis in adults: a six-month studyMichael Meurer
Hautklinik, Universitätsklinikum der TU, Dresden, Deutschland
Dermatology 205:271-7. 2002..We assessed whether early treatment of AD signs/symptoms reduces the need for topical corticosteroids...
- Tacrolimus ointment for the treatment of atopic dermatitis: clinical and pharmacologic effectsM Joyce Rico
Fujisawa Healthcare, Inc, 3 Pookway North Deerfeild, IL 60022, USA
Allergy Asthma Proc 23:191-7. 2002..Additional mechanisms of action of tacrolimus relevant in the pathogenesis of inflammatory skin disorders are discussed...
- Comparison of cutaneous tolerance and efficacy of calcitriol 3 microg g(-1) ointment and tacrolimus 0.3 mg g(-1) ointment in chronic plaque psoriasis involving facial or genitofemoral areas: a double-blind, randomized controlled trialY H Liao
Department of Dermatology, National Taiwan University Hospital, College of Medicine, National Taiwan University, 7, Chung Shan South Road, Taipei 100, Taiwan
Br J Dermatol 157:1005-12. 2007..Two nonsteroidal topical agents, calcitriol and tacrolimus, have been reported to be effective and safe for psoriatic lesions on sensitive areas. However, no comparative studies between calcitriol and tacrolimus have been reported...
- Pimecrolimus 1% cream in the treatment of facial psoriasis: a 16-week open-label studyArnd Jacobi
Department of Dermatology, University Hospital Marburg, Marburg, Germany
Dermatology 216:133-6. 2008..Facial psoriasis requires a treatment approach other than topical corticosteroids which bear the risk of skin atrophy. Topical pimecrolimus has been shown to be effective in atopic eczema and recently in psoriasis...
- A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planusLida Radfar
Oral Medicine, Department of Oral Diagnostic Sciences, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:187-93. 2008..Existing clinical trials have shown that topical corticosteroids are often effective in the management of oral lichen planus (OLP). However, tacrolimus has recently been shown to be an effective treatment of OLP...
- A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patientsMarie Lodén
ACO HUD AB, Stockholm, Sweden
Acta Derm Venereol 82:45-7. 2002..The study showed equal effects on skin dryness as judged by the patients and the dermatologist. In conclusion, a glycerin containing cream appears to be a suitable alternative to urea/sodium chloride in the treatment of atopic dry skin...
- [FK 506 ointment 0.1 % - A new therapeutic option for atopic blepharitis. Clinical trial with 14 patients]K Mayer
Klin Monatsbl Augenheilkd 218:733-6. 2001..CONCLUSIONS: Topical FK 506 0.1 % ointment turns out to be an excellent therapeutic option for treatment of severe atopic blepharitis. Long-term efficacy and safety have to be evaluated in long-term follow-up studies...
- Safe and effective treatment of refractory facial lesions in atopic dermatitis using topical tacrolimus following corticosteroid discontinuationT Kawakami
Department of Dermatology, St. Marianna University School of Medicine, Kawasaki, Japan
Dermatology 203:32-7. 2001..05). CONCLUSION: The present results indicate that topical tacrolimus treatment following corticosteroid discontinuation is safe and effective in refractory facial AD...
- Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointmentA Wollenberg
Department of Dermatology and Allergy, Ludwig Maximilian University, Munich, Germany
Allergy 63:742-50. 2008..This 12-month, European, multicentre, randomized study investigated whether the proactive use of 0.1% tacrolimus ointment applied twice weekly can keep AD in remission and reduce the incidence of disease exacerbations (DE)...
- A randomized, double-blind, multicenter trial comparing fluticasone propionate cream, 0.05%, and hydrocortisone-17-butyrate cream, 0.1%, applied twice daily for 4 weeks in the treatment of psoriasisM James
Department of Dermatology, Royal Berkshire Hospital, England
Cutis 67:2-9. 2001..Adverse events were limited to mild-to-moderate pruritus with fluticasone propionate (3.2%) and hydrocortisone-17-butyrate (1.7%) and mild skin warmth with hydrocortisone-17-butyrate (1.7%)...
- Tacrolimus ointment for the management of atopic dermatitisMalcolm Rustin
Department of Dermatology, Royal Free Hospital, London NW3 2QG
Hosp Med 64:214-7. 2003..Backed by strong clinical data, tacrolimus ointment is a valuable addition to topical steroids in the management of moderate-to-severe atopic dermatitis...
- Treatment of pityriasis rubra pilaris with pimecrolimus cream 1%Stamatis Gregoriou
University of Athens Medical School, Department of Dermatology, A Sygros Hospital, Athens, Greece
J Drugs Dermatol 6:340-2. 2007..We report the case of a young man with pityriasis rubra pillaris limited to the scalp and face, which cleared completely after application of pimecrolimus 1% cream for 2 weeks...
- Topical tacrolimus ointment is an effective therapy for Hailey-Hailey diseaseCarsten Sand
Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark
Arch Dermatol 139:1401-2. 2003
- Blood concentrations of pimecrolimus in adult patients with atopic dermatitis following intermittent administration of pimecrolimus cream 1% (Elidel) for up to 1 yearEdwin J M Van Leent
Academic Medical Centre AMC, Amsterdam, The Netherlands
J Dermatolog Treat 18:19-22. 2007..To determine blood concentrations of pimecrolimus after long-term intermittent administration of pimecrolimus cream 1% in adult patients with extensive atopic dermatitis (AD)...
- An experimental ointment formulation of pimecrolimus is effective in psoriasis without occlusionUlrich Mrowietz
Department of Dermatology, University of Schleswig Holstein, Campus Kiel, Germany
Acta Derm Venereol 83:351-3. 2003..This is the first study reporting a significant therapeutic effect of pimecrolimus in an ointment formulation applied without occlusion to psoriatic plaques...
- The safety and efficacy of tacrolimus therapy in patients younger than 2 years with atopic dermatitisRishi R Patel
Department of Dermatology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
Arch Dermatol 139:1184-6. 2003..We wanted to determine whether topical tacrolimus therapy is safe and effective in patients with AD who are younger than 2 years...
- Tacrolimus ointment 0.1% in the treatment of nickel-induced allergic contact dermatitisYamini V Saripalli
Division of Dermatology, University of Kansas Medical Center, Kansas City 66160 7319, USA
J Am Acad Dermatol 49:477-82. 2003..It is currently approved for the treatment of moderate to severe atopic dermatitis, a Th2-mediated disease, in children and adults...
- 0.03% Tacrolimus ointment applied once or twice daily is more efficacious than 1% hydrocortisone acetate in children with moderate to severe atopic dermatitis: results of a randomized double-blind controlled trialS Reitamo
Department of Dermatology, Helsinki University Central Hospital, Helsinki, Finland
Br J Dermatol 150:554-62. 2004..Topical corticosteroids are the usual treatment for atopic dermatitis (AD) in children but can have side-effects...
- An open-label efficacy pilot study with pimecrolimus cream 1% in adults with facial seborrhoeic dermatitis infected with HIVA P De Moraes
São José Hospital of Infectious Diseases, Ceara, Brazil
J Eur Acad Dermatol Venereol 21:596-601. 2007..Seborrhoeic dermatitis (SD) is a common dermatosis in human immunodeficiency virus (HIV)-positive patients, many of whom do not respond satisfactorily to conventional topical treatments such as corticosteroids and antifungals...
- The safety of tacrolimus ointment for the treatment of atopic dermatitis: a reviewM H A Rustin
Department of Dermatology, Royal Free Hospital, Pond Street, London NW3 2QG, UK
Br J Dermatol 157:861-73. 2007....
- Occlusive treatment of chronic hand dermatitis with pimecrolimus cream 1% results in low systemic exposure, is well tolerated, safe, and effective. An open studyDiamant Thaci
Department of Dermatology and Venereology, J W Goethe University School of Medicine, Frankfurt, Germany
Dermatology 207:37-42. 2003..Pimecrolimus cream 1% (Elidel, SDZ ASM 981) is a novel, non-steroid inflammatory cytokine inhibitor, effective in the treatment of atopic dermatitis. Here, we evaluate the treatment of chronic hand dermatitis with pimecrolimus cream 1%...
- PEGylated Lysostaphin for Staphylococcal InfectionsJohn Kokai Kun; Fiscal Year: 2004..aureus infections (as a nasal cream) and in treating topical and systemic S. aureus infections, including S. aureus endocarditis. ..
- A novel anti-scar peptide for cutaneous wound repairChia Soo; Fiscal Year: 2013..g., silicone sheeting, topical ointments, and lasers)...
- Self-Applied Wearable Ultrasound Therapy for Osteoarthritis Management in Rural CGEORGE KENNETH LEWIS; Fiscal Year: 2013..ultrasound have been shown to facilitate wound and bone fracture healing, to promote the penetration of topical ointments into the skin and found to enhance a variety healthcare applications...
- A novel therapeutic for the treatment of persistent corneal epithelial defectsBennie H Jeng; Fiscal Year: 2010..traditional therapy of PED consists of aggressive lubrication with preservative-free artificial tears and ointments, the use of bandage soft contact lenses, pressure patching, punctal plugging, and the surgical closure of the ..
- Pre-clinical Studies on Lupinus termis Seeds ExtractMIKHAIL ANTOUN; Fiscal Year: 2003..develop a standardized reproducible method for the preparation of the extract; 3) determine the stability of the ointments prepared from the extract; 4) carry out a repeat-dose toxicology study of the ointments, for nine months, in ..
- Laminin-based protein therapeutics for junctional epidermolysis bullosaVitali Alexeev; Fiscal Year: 2009..prevention of mechanical trauma and infection via the use of protective loose garments and antibiotic creams and ointments. Previously we proposed and recently demonstrated that individual chains of laminin 332 (23 in particular) can ..
- MINIMIZING BLOOD TO EYE RATIO OF TOPICAL EYE MEDICATIONSVincent Lee; Fiscal Year: 1992..on the balance between ocular and systemic drug absorption; these include aqueous solutions, polymer solutions, ointments, and gels, and (4) To demonstrate that an erodible polymeric insert is more effective than existing vehicles in ..
- GANGLIOSIDE GENE MODULATION EFFECT ON CELL MOTILITYAmy Paller; Fiscal Year: 2007..These studies will provide information about the role of gangliosides in caveolin-1 mediated signaling and may lead to novel therapies for patients with abnormal healing responses. ..
- Nisin-based topical formulation for treatment of anthraxJohn Kokai Kun; Fiscal Year: 2003..The final product is intended to minimize the danger for those exposed to B. anthracis and should also be effective for disinfection of other bioterrorism agents and for nosocomial pathogens in the healthcare setting. ..
- CLINICAL TRANSLATIONAL RESEARCH IN DERMATOLOGYSewon Kang; Fiscal Year: 2004..abstract_text> ..
- Antiretroviral Therapy of AIDS-Related Kaposi's Sarcoma in AfricaJeffrey Martin; Fiscal Year: 2009..Findings from this work will both help to inform clinical care of patients with AIDS-related KS in Africa and provide biological insights into the effect of antiretroviral therapy on underlying KSHV infection. ..
- Conference--Dermatologic Disease in Skin of ColorSusan Taylor; Fiscal Year: 2002..They believe that these presentations and discussions will lead to a greater interest in the specific problem related to access to care for dermatologic disease among persons of color. ..
- SunSmart America: Evaluating a School-based CurriculumRobert Kirsner; Fiscal Year: 2008..The results will be used for planning to implement the SunSmart America curriculum throughout Florida and nationwide. [unreadable] [unreadable] [unreadable]..
- Skin Blood Flow in Diabetes: Local and Reflex ControlNisha Charkoudian; Fiscal Year: 2007....
- Family-Centered Diabetes ProjectCarla Herman; Fiscal Year: 2006..iv) Improvement in outcome measures will be maintained by intervention participants when compared to the comparison group at 6 and 12 months post intervention. ..
- STATISTICAL INFERENCE FOR SPARSE CATEGORICAL DATAAlan Agresti; Fiscal Year: 2003..The two types of improved intervals will be compared (In some cases, approximate may be better because of the inherent conservativeness of exact methods for discrete data), and extensions will be developed for stratified data. ..
- Colorectal Screening Capacity Building ConferenceDavid Alberts; Fiscal Year: 2003..Continued capacity building and future collaboration will also be woven into this conference to serve as a stone to build upon in the future. ..
- UV-induced collagen reduction: treating skin sclerodermaSewon Kang; Fiscal Year: 2005....
- Ophthalmic Antibiotic Resistance StudyKirk Wilhelmus; Fiscal Year: 2003..abstract_text> ..
- A Molecular Signature of Early Cervical CarcinomaConcepcion Diaz Arrastia; Fiscal Year: 2007..I propose to identify a genomic and proteomic signature of cervical cancer that will predict the aggressive behavior of the tumor and function clinically to develop molecular-based treatment plans. ..
- Dermatomyositis Skin Disease Severity Measure ValidationJOSPEH JORIZZO; Fiscal Year: 2003..abstract_text> ..