capsules

Summary

Summary: Hard or soft soluble containers used for the oral administration of medicine.

Top Publications

  1. ncbi Enzyme-responsive release of encapsulated proteins from biodegradable hollow capsules
    Yuki Itoh
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biomacromolecules 7:2715-8. 2006
  2. ncbi Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period cros
    Gavin R Graff
    Penn State Milton S Hershey Medical Center, Penn State Medical School, Department of Pediatrics, Hershey, Pennsylvania 17033 0850, USA
    Clin Ther 32:89-103. 2010
  3. ncbi Zeta-potentials of alginate-PLL capsules: a predictive measure for biocompatibility?
    Paul De Vos
    Department of Pathology and Laboratory Medicine, Section of Medical Biology, Division of Immunoendocrinology, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Biomed Mater Res A 80:813-9. 2007
  4. ncbi Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines
    B L Strand
    Department of Biotechnology, Norwegian University of Science and Technology, Trondheim
    Cell Transplant 10:263-75. 2001
  5. ncbi Fourier transform infrared spectroscopy studies of alginate-PLL capsules with varying compositions
    Chris G van Hoogmoed
    Department of Biomedical Engineering, Section of Bioadhesion, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biomed Mater Res A 67:172-8. 2003
  6. ncbi Cryopreservation of spermatozoa in alginic acid capsules
    Andreas Herrler
    Department of Anatomy and Reproductive Biology, Medical School, RWTH Aachen, Aachen, Germany
    Fertil Steril 85:208-13. 2006
  7. ncbi Efficacy and safety of single-triple capsules of bismuth biskalcitrate, metronidazole and tetracycline, given with omeprazole, for the eradication of Helicobacter pylori: an international multicentre study
    C O'Morain
    Department of Gastroenterology, Adelaide and Health Hospital, Tallaght, Dublin, Ireland
    Aliment Pharmacol Ther 17:415-20. 2003
  8. ncbi A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
    N Gubergrits
    Department of Internal Diseases, Donetsk National Medical University, Donetsk, Ukraine
    Aliment Pharmacol Ther 33:1152-61. 2011
  9. ncbi Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese
    Maija Saxelin
    Valio Ltd, Research and Development, P O Box 30, FI 00039 Valio, Helsinki, Finland
    Int J Food Microbiol 144:293-300. 2010
  10. ncbi Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study
    Wang Ya
    Department of Gynecology, Yuyao Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Am J Obstet Gynecol 203:120.e1-6. 2010

Detail Information

Publications292 found, 100 shown here

  1. ncbi Enzyme-responsive release of encapsulated proteins from biodegradable hollow capsules
    Yuki Itoh
    Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Biomacromolecules 7:2715-8. 2006
    Biodegradable hollow capsules encapsulating proteins were prepared via layer-by-layer assembly of chitosan and dextran sulfate on protein-entrapping mesoporous silica particles and the subsequent removal of the silica...
  2. ncbi Efficacy and tolerability of a new formulation of pancrelipase delayed-release capsules in children aged 7 to 11 years with exocrine pancreatic insufficiency and cystic fibrosis: a multicenter, randomized, double-blind, placebo-controlled, two-period cros
    Gavin R Graff
    Penn State Milton S Hershey Medical Center, Penn State Medical School, Department of Pediatrics, Hershey, Pennsylvania 17033 0850, USA
    Clin Ther 32:89-103. 2010
    ..The US Food and Drug Administration regulations now require all PERT products to undergo clinical efficacy and safety studies before they can be considered for marketing approval...
  3. ncbi Zeta-potentials of alginate-PLL capsules: a predictive measure for biocompatibility?
    Paul De Vos
    Department of Pathology and Laboratory Medicine, Section of Medical Biology, Division of Immunoendocrinology, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Biomed Mater Res A 80:813-9. 2007
    ..Clinical application, however, is hampered by insufficient insight in factors influencing biocompatibility of the capsules. By now, it has been accepted that not only the chemical composition of the materials applied but also other ..
  4. ncbi Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines
    B L Strand
    Department of Biotechnology, Norwegian University of Science and Technology, Trondheim
    Cell Transplant 10:263-75. 2001
    ..By combining soluble PLL and alginate both the toxic and TNF-inducing effects of PLL were reduced. The implications of these data are to use alginate microcapsules with low amounts of PLL for transplantation purposes...
  5. ncbi Fourier transform infrared spectroscopy studies of alginate-PLL capsules with varying compositions
    Chris G van Hoogmoed
    Department of Biomedical Engineering, Section of Bioadhesion, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Biomed Mater Res A 67:172-8. 2003
    ..however, is hampered by insufficient insight into the factors that influence the biocompatibility of the capsules. Capsules prepared of alginates with a high guluronic (G) acid content proved to be more adequate for clinical ..
  6. ncbi Cryopreservation of spermatozoa in alginic acid capsules
    Andreas Herrler
    Department of Anatomy and Reproductive Biology, Medical School, RWTH Aachen, Aachen, Germany
    Fertil Steril 85:208-13. 2006
    ..To develop a method of freezing small amounts of spermatozoa in polymerized alginic acid drops, which can be liquified after thawing for recovery of the spermatozoa...
  7. ncbi Efficacy and safety of single-triple capsules of bismuth biskalcitrate, metronidazole and tetracycline, given with omeprazole, for the eradication of Helicobacter pylori: an international multicentre study
    C O'Morain
    Department of Gastroenterology, Adelaide and Health Hospital, Tallaght, Dublin, Ireland
    Aliment Pharmacol Ther 17:415-20. 2003
    ..The high prevalence of Helicobacter pylori resistance to metronidazole demands treatments more effective than standard bismuth-based triple therapy against these strains...
  8. ncbi A 6-month, open-label clinical trial of pancrelipase delayed-release capsules (Creon) in patients with exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery
    N Gubergrits
    Department of Internal Diseases, Donetsk National Medical University, Donetsk, Ukraine
    Aliment Pharmacol Ther 33:1152-61. 2011
    ..Pancreatic enzyme replacement therapy (PERT) is necessary to prevent severe maldigestion and unwanted weight loss associated with exocrine pancreatic insufficiency (EPI) due to chronic pancreatitis (CP) or pancreatic surgery (PS)...
  9. ncbi Persistence of probiotic strains in the gastrointestinal tract when administered as capsules, yoghurt, or cheese
    Maija Saxelin
    Valio Ltd, Research and Development, P O Box 30, FI 00039 Valio, Helsinki, Finland
    Int J Food Microbiol 144:293-300. 2010
    Most clinical studies of probiotics use freeze-dried, powdered bacteria or bacteria packed in capsules. However, probiotics are commercially available in various food matrices, which may affect their persistence in the gastrointestinal ..
  10. ncbi Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-controlled study
    Wang Ya
    Department of Gynecology, Yuyao Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Am J Obstet Gynecol 203:120.e1-6. 2010
    We assessed the effectiveness of vaginal probiotic capsules for recurrent bacterial vaginosis (BV) prevention.
  11. ncbi Alginate-based encapsulation of cells: past, present, and future
    Heiko Zimmermann
    Lehrstuhl fur Biotechnologie, Biozentrum, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    Curr Diab Rep 7:314-20. 2007
    ..Focus on the development of good manufacturing practice-conforming microfluidic chip technology for generation of immunoisolated transplants and on cryopreservation technology will bring the cell-based therapy to the market and clinics...
  12. pmc Diagnosis of small bowel Crohn's disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis
    J G Albert
    First Department of Medicine, Martin Luther University Hospital and Clinics, D 06097 Halle Saale, Germany
    Gut 54:1721-7. 2005
    ..We prospectively investigated CE, MRI, and double contrast fluoroscopy in patients with suspected small bowel Crohn's disease...
  13. ncbi Templated synthesis of single-component polymer capsules and their application in drug delivery
    Yajun Wang
    Centre for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Vic, Australia
    Nano Lett 8:1741-5. 2008
    ....
  14. ncbi Local endostatin treatment of gliomas administered by microencapsulated producer cells
    T A Read
    Department of Anatomy and Cell Biology, University of Bergen, Norway
    Nat Biotechnol 19:29-34. 2001
    ..the implantation period 70% of the encapsulated cells remained viable, as opposed to 85% in in vitro-cultured capsules. Rats that received transplants of BT4C glioma cells, together with endostatin-producing capsules (0...
  15. ncbi Evaluation of high molecular weight poly(oxyethylene) (Polyox) polymer: studies of flow properties and release rates of furosemide and captopril from controlled-release hard gelatin capsules
    M Efentakis
    University of Athens, School of Pharmacy, Department of Pharmaceutical Technology, Greece
    Pharm Dev Technol 5:339-46. 2000
    ..of the molecular weight of polymers as diluents on the release rate of furosemide and captopril from hard gelatin capsules were evaluated...
  16. ncbi Alginate-encapsulated human hepatoblastoma cells in an extracorporeal perfusion system improve some systemic parameters of liver failure in a xenogeneic model
    Tony M Rahman
    Center for Hepatology, Royal Free and University College Medical School, London, UK
    Artif Organs 28:476-82. 2004
    ..Furthermore, such capsules have the advantage of cryopreservability, and can be readily manipulated, e.g...
  17. ncbi Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity
    C M Ofner
    Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43rd Street, Philadelphia, Pennsylvania 19104, USA
    J Pharm Sci 90:79-88. 2001
    ..This report also includes a summary of the literature on agents that reduce gelatin and capsule shell dissolution and the possible mechanisms of this not-so-simple problem...
  18. ncbi Effects of food on the single-dose pharmacokinetics/pharmacodynamics of tizanidine capsules and tablets in healthy volunteers
    Jaymin Shah
    Elan Pharmaceuticals, Inc, San Diego, California, USA
    Clin Ther 28:1308-17. 2006
    ..A multiparticulate capsule formulation of the alpha2-adrenergic agonist tizanidine has been developed to decrease C(max), AUC, and associated somnolence, while maintaining efficacy...
  19. ncbi Novel solvent-free fabrication of biodegradable poly-lactic-glycolic acid (PLGA) capsules for antibiotics and rhBMP-2 delivery
    Shih Jung Liu
    Department of Mechanical Engineering, Chang Gung University, Taiwan
    Int J Pharm 330:45-53. 2007
    ..The report was to develop novel solvent-free biodegradable capsules for antibiotics and growth factors delivery...
  20. ncbi In situ detection of aromatic compounds with biosensor Pseudomonas putida cells preserved and delivered to soil in water-soluble gelatin capsules
    Aitor de las Heras
    Systems Biology Program, Centro Nacional de Biotecnologia, CSIC, Campus de Cantoblanco, Madrid, Spain
    Anal Bioanal Chem 400:1093-104. 2011
    ..properties adequate for formulating the biosensor agent in water-soluble but otherwise hard dry gelatine capsules with a long shelf life...
  21. ncbi Adipose-derived stem cell therapy for intervertebral disc regeneration: an in vitro reconstructed tissue in alginate capsules
    Paolo Gaetani
    Unità Operativa di Neurochirurgia, Istituto Clinico Humanitas, Milan, Italy
    Tissue Eng Part A 14:1415-23. 2008
    ..Technological resources are available for NP cell encapsulation intended for regenerating the intervertebral disc...
  22. ncbi Quantitative analysis of anthocyanins in Euterpe oleracea (açaí) dietary supplement raw materials and capsules by Q-TOF liquid chromatography/mass spectrometry
    Vanisree Mulabagal
    Department of Pharmacal Sciences, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA
    Pharm Biol 50:1289-96. 2012
    ..Anthocyanins and their aglycons are responsible for the dense color of açaí fruit and are associated with a wide spectrum of health promoting effects...
  23. ncbi The effect of host factors and capsule composition on the cellular overgrowth on implanted alginate capsules
    A King
    Department of Medical Cell Biology, Box 571, Biomedical Centre, Uppsala University, SE 751 23 Uppsala, Sweden
    J Biomed Mater Res 57:374-83. 2001
    Microencapsulation of islets of Langerhans in alginate/poly-L-lysine (PLL)/alginate capsules may provide a method for transplantation in the absence of immunosuppression...
  24. ncbi Polyelectrolyte multilayer capsules as vehicles with tunable permeability
    Alexei A Antipov
    Max Planck Institute of Colloids and Interfaces, D 14424 Golm Potsdam, Germany
    Adv Colloid Interface Sci 111:49-61. 2004
    ..1 to 10 mum can be used for templating such PE capsules. The shell thickness can be tuned in nanometer range by assembling of defined number of PE layers...
  25. ncbi Design and optimization of self-nanoemulsifying drug delivery systems (SNEDDS) for enhanced dissolution of gemfibrozil
    Ana Maria Sierra Villar
    Pharmacy and Pharmaceutical Technology Department Faculty of Pharmacy, University of Barcelona, Joan XXIII Avenue, 08028, Barcelona, Spain
    Int J Pharm 431:161-75. 2012
    ..This paper provides an overview of the SNEDDS of the gemfibrozil as a promising alternative to improve oral absorption...
  26. ncbi Superior cell delivery features of poly(ethylene glycol) incorporated alginate, chitosan, and poly-L-lysine microcapsules
    Tasima Haque
    Biomedical Technology and Cell Therapy Research Laboratory, Department of Biomedical Engineering and Artificial Cells and Organs Research Center, Faculty of Medicine, McGill University, 3775 University Street, Montreal, Quebec H3A 2B4, Canada
    Mol Pharm 2:29-36. 2005
    ..The study revealed the potential of using PEG-incorporated alginate, chitosan, and PLL microcapsules for encapsulating live cells producing proteins and hormones for therapy...
  27. ncbi A new fenofibrate formulation: results of six single-dose, clinical studies of bioavailability under fed and fasting conditions
    Pol Henri Guivarc'h
    SkyePharma Inc, Montreal, Quebec, Canada
    Clin Ther 26:1456-69. 2004
    ..Even the newest marketed formulations, micronized fenofibrate (MF) 200-mg capsules and microcoated fenofibrate (MCF) 160-mg tablets, require administration with meals to increase bioavailability...
  28. ncbi Biocompatibility and physicochemical characteristics of alginate-polycation microcapsules
    S K Tam
    Laboratoire d innovation et d analyse de bioperformance, Institut de Génie Biomédical, Ecole Polytechnique, Montreal, Quebec, Canada
    Acta Biomater 7:1683-92. 2011
    ..Thus, alginate-polycation interactions for membrane formation are more important for biocompatibility than either the quantity of polycation at the surface or the alginate coating...
  29. ncbi Layer-by-layer assembly of microcapsules and their biomedical applications
    Weijun Tong
    MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
    Chem Soc Rev 41:6103-24. 2012
    Nanoengineered multifunctional capsules with tailored structures and properties are of particular interest due to their multifunctions and potential applications as new colloidal structures in diverse fields...
  30. ncbi Microencapsulation of a probiotic and prebiotic in alginate-chitosan capsules improves survival in simulated gastro-intestinal conditions
    María Chávarri
    Food Area, Fundación LEIA Technological Development Centre, Parque Tecnológico de Alava, Minano, Spain
    Int J Food Microbiol 142:185-9. 2010
    ..gasseri and B. bifidum with alginate and a chitosan coating offers an effective means of delivery of viable bacterial cells to the colon and maintaining their survival during simulated gastric and intestinal juice...
  31. ncbi Pancrelipase delayed-release capsules (CREON) for exocrine pancreatic insufficiency due to chronic pancreatitis or pancreatic surgery: A double-blind randomized trial
    David C Whitcomb
    Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    Am J Gastroenterol 105:2276-86. 2010
    ..Our objective was to assess the efficacy and safety of a new formulation of pancrelipase (pancreatin) delayed-release 12,000-lipase unit capsules (CREON) in patients with EPI due to CP or PS.
  32. ncbi Multicompartmental micro- and nanocapsules: hierarchy and applications in biosciences
    Mihaela Delcea
    Max Planck Institute of Colloids and Interfaces, Research Park Golm, Potsdam 14424, Germany
    Macromol Biosci 10:465-74. 2010
    ..Applications of multicompartmentalized microcapsules for simultaneous multiple drug delivery in bio-medicine are discussed...
  33. pmc Dissolving microneedles for transdermal drug delivery
    Jeong W Lee
    School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, 311 Ferst Drive, Atlanta, GA 30332, USA
    Biomaterials 29:2113-24. 2008
    ..We conclude that dissolving microneedles can be designed to gently encapsulate molecules, insert into skin, and enable bolus or sustained release delivery...
  34. ncbi Nimodipine semi-solid capsules containing solid dispersion for improving dissolution
    Yunzhe Sun
    School of Pharmacy, Department of Pharmaceutics, Shenyang Pharmaceutical University, No 103 Wenhua Road, Shenyang 110016, PR China
    Int J Pharm 359:144-9. 2008
    ..solid dispersion (NMD-SD) powder to a mixture of Plasdone-S630 and PEG400, and then transferring it to hard HPMC capsules, resulted in nimodipine semi-solid capsules (NMD-SSC)...
  35. ncbi Size-dependent bioadhesion of micro- and nanoparticulate carriers to the inflamed colonic mucosa
    A Lamprecht
    Department of Biopharmacy and Pharmaceutical Technology, Saarland University, Saarbrucken, Germany
    Pharm Res 18:788-93. 2001
    ..Local delivery of an entrapped drug could reduce side effects and would be a distinct improvement compared with existing colon delivery devices...
  36. pmc Simultaneous recordings of oesophageal acid exposure with conventional pH monitoring and a wireless system (Bravo)
    S Bruley des Varannes
    Institut des Maladies de L appareil Digestif, CHU Hotel Dieu, Nantes, France
    Gut 54:1682-6. 2005
    ..Recently, a telemetric catheter free system (CFS) (Bravo; Medtronic) was developed. The aim of this study was to determine the concordance of data between the conventional pH measurement system (CPHMS) and the CFS Bravo...
  37. ncbi Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    Bengt Winblad
    Karolinska Institutet Alzheimer Research Center, Huddinge, Sweden
    Int J Geriatr Psychiatry 22:485-91. 2007
    ..Transdermal patches may offer advantages over conventional oral formulations...
  38. pmc Acid reflux event detection using the Bravo wireless versus the Slimline catheter pH systems: why are the numbers so different?
    J E Pandolfino
    Division of Gastroenterology, Department of Medicine, Northwestern University, Feinberg School of Medicine, Suite 1400, Chicago, Illinois 60611, USA
    Gut 54:1687-92. 2005
    ..This study analysed the relative accuracy of the Bravo wireless and the Slimline catheter-Mark III Digitrapper pH systems in the detection of acid reflux events...
  39. ncbi Pro-inflammatory cytokine inhibition in the primate using microencapsulated antisense oligomers to NF-kappaB
    Carl W Oettinger
    College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA, USA
    J Microencapsul 24:337-48. 2007
    ..Phagocytosis of microcapsules and intracellular release of ASO in macrophages was evaluated...
  40. ncbi Stimuli-responsive LbL capsules and nanoshells for drug delivery
    Mihaela Delcea
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam Golm, Germany
    Adv Drug Deliv Rev 63:730-47. 2011
    Review of basic principles and recent developments in the area of stimuli responsive polymeric capsules and nanoshells formed via layer-by-layer (LbL) is presented...
  41. ncbi Survival and maturation of microencapsulated porcine neonatal pancreatic cell clusters transplanted into immunocompetent diabetic mice
    Abdulkadir Omer
    Section on Islet Transplantation and Cell Biology, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 52:69-75. 2003
    ..Hyperglycemic blood glucose levels after explantation of the capsules confirmed the function of the encapsulated NPCCs...
  42. ncbi Layer-by-layer-assembled capsules and films for therapeutic delivery
    Alisa L Becker
    Department of Chemical and Biomolecular Engineering, The University of Melbourne, Centre for Nanoscience and Nanotechnology, Parkville, Victoria 3010, Australia
    Small 6:1836-52. 2010
    ..These multilayered materials, both as capsules and thin fi lms, can encapsulate a high payload of toxic or sensitive drugs, and can be readily engineered and ..
  43. ncbi Methylphenidate controlled-delivery capsules (EquasymXL, Metadate CD): a review of its use in the treatment of children and adolescents with attention-deficit hyperactivity disorder
    Vanessa R Anderson
    Wolters Kluwer Health, Adis, Auckland, New Zealand
    Paediatr Drugs 8:319-33. 2006
    ....
  44. ncbi Chitosan: properties, preparations and application to microparticulate systems
    H S Kas
    Hacettepe University, Pharmacy Faculty, Pharmaceutical Technology Department, Ankara, Turkey
    J Microencapsul 14:689-711. 1997
    ..In this paper, the attractive properties and broad applications of chitosan-based microparticles, their versatile properties, different preparation methods, and pharmaceutical and biopharmaceutical applications are reviewed...
  45. ncbi Protective effects of Guizhi-Fuling-Capsules on rat brain ischemia/reperfusion injury
    Tie Jun Li
    Department of Pharmacology, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China
    J Pharmacol Sci 105:34-40. 2007
    Previous studies revealed that Guizhi-Fuling-Capsules (GZFLC), a traditional Chinese medical (Kampo) formulation composed of five kinds of medicinal plants, Cinnamomum cassia BLUME (Cinnamomi Cortex), Paeonia lactiflora PALL...
  46. ncbi Gastric emptying of a non-digestible solid: assessment with simultaneous SmartPill pH and pressure capsule, antroduodenal manometry, gastric emptying scintigraphy
    D Cassilly
    Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA
    Neurogastroenterol Motil 20:311-9. 2008
    ..However, in some subjects, the SmartPill emptied with isolated antral contractions, an unappreciated mechanism for emptying of a non-digestible solid...
  47. ncbi Phase I clinical study of fish oil fatty acid capsules for patients with cancer cachexia: cancer and leukemia group B study 9473
    C P Burns
    The University of Iowa Cancer Center, Iowa City, 52242, USA
    Clin Cancer Res 5:3942-7. 1999
    ..of this study was to determine the maximum tolerated dose and dose-limiting toxicities of fish oil fatty acid capsules containing omega-3 fatty acid ethyl esters...
  48. ncbi Biocompatibility of microcapsules for cell immobilization elaborated with different type of alginates
    G Orive
    Laboratory of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of the Basque Country, Vitoria Gasteiz, Spain
    Biomaterials 23:3825-31. 2002
    ..Consequently, this work revealed that purity of the alginate rather than their chemical composition, is probably of greater importance in determining microcapsule biocompatibility...
  49. ncbi Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane
    V F Duvivier-Kali
    Section of Islet Transplantation and Cell Biology, Joslin Diabetes Center, Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Diabetes 50:1698-705. 2001
    ..with BaCl(2) without a traditional permselective component, which allows the production of biocompatible capsules that allow prolonged survival of syngeneic and allogeneic transplanted islets in diabetic BALB/c and NOD mice for ..
  50. ncbi Long-term effectiveness and safety of dexmethylphenidate extended-release capsules in adult ADHD
    Lenard A Adler
    New York University School of Medicine, New York, NY 10016, USA
    J Atten Disord 12:449-59. 2009
    ..This study evaluates dexmethylphenidate extended release (d-MPH-ER) in adults with ADHD...
  51. ncbi Immunoprotection against influenza H5N1 virus by oral administration of enteric-coated recombinant Lactococcus lactis mini-capsules
    Han Lei
    School of Life Science and Technology, Shanghai Jiao Tong University, Shanghai, 200240, PR China
    Virology 407:319-24. 2010
    ..The vectors were then formulated into a mini-capsule dosage form and fed to mouse. Four doses of oral administration rendered complete protection of the mouse against lethal challenges of H5N1 virus...
  52. ncbi An encapsulation system for the immunoisolation of pancreatic islets
    T Wang
    Center for Microgravity Research, Vanderbilt University School of Engineering, Nashville, TN 37235, USA
    Nat Biotechnol 15:358-62. 1997
    ..This new capsule formulation and encapsulation system allows independent adjustments of capsule size, wall thickness, mechanical strength, and permeability, which may offer distinct advantages for immunoisolating cells...
  53. ncbi Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule vs. traditional 24-h oesophageal pH monitoring--a randomized trial
    W M Wong
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and University of Arizona Health Sciences Center, Tucson, AZ 85723, USA
    Aliment Pharmacol Ther 21:155-63. 2005
    ..The wireless pH is a new technique to monitor oesophageal acid exposure...
  54. ncbi Relative bioavailability of lisdexamfetamine 70-mg capsules in fasted and fed healthy adult volunteers and in solution: a single-dose, crossover pharmacokinetic study
    Suma Krishnan
    New River Pharmaceuticals Inc, 3 W Shore Rd, Belvedere, CA 94920, USA
    J Clin Pharmacol 48:293-302. 2008
    ..These findings indicate that food does not have a significant effect on d-amphetamine or lisdexamfetamine bioavailability in healthy adults and that lisdexamfetamine was well tolerated...
  55. ncbi Ambulatory esophageal pH monitoring using a wireless system
    John E Pandolfino
    Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611 3008, USA
    Am J Gastroenterol 98:740-9. 2003
    ..An alternative to conventional pH monitoring is the wireless Medtronic Bravo pH System. The aim of this study was to evaluate the safety, performance, and tolerability of this system...
  56. ncbi Absorption and subjective effects of caffeine from coffee, cola and capsules
    A Liguori
    Department of Psychiatry, University of Vermont, Burlington 05401, USA
    Pharmacol Biochem Behav 58:721-6. 1997
    ..caffeine consumption = 456 mg) ingested 400 mg caffeine via 12 oz unsweetened coffee, 24 oz sugar-free cola or 2 capsules in a random, double-blind, placebo-controlled, within-subjects design...
  57. ncbi Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-contro
    Joseph Stauffer
    Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals, Inc, Bridgewater, New Jersey, USA
    Clin Drug Investig 29:777-90. 2009
    ..ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules, indicated for treatment of chronic, moderate to severe pain, contain polymer-coated pellets of morphine, each ..
  58. ncbi Chitosan microparticles for oral vaccination: preparation, characterization and preliminary in vivo uptake studies in murine Peyer's patches
    I M van der Lubben
    Leiden/Amsterdam Center for Drug Research, Division of Pharmaceutical Technology, Leiden, Netherlands
    Biomaterials 22:687-94. 2001
    ..Since uptake by Peyer's patches is an essential step in oral vaccination, these results show that the presently developed porous chitosan microparticles are a very promising vaccine delivery system...
  59. ncbi Light-responsive polyelectrolyte/gold nanoparticle microcapsules
    Alexandra S Angelatos
    Center for Nanoscience and Nanotechnology, Department of Chemical and Biomolecular Engineering, The University of Melbourne, Parkville, Victoria 3010, Australia
    J Phys Chem B 109:3071-6. 2005
    ..The nanostructured capsules were loaded with macromolecules (fluorescein isothiocyanate-labeled dextran) by exploiting the pH-dependence of ..
  60. ncbi Rivastigmine exposure provided by a transdermal patch versus capsules
    Francois Mercier
    Novartis Pharma AG, Basel, Switzerland
    Curr Med Res Opin 23:3199-204. 2007
    ..The objective of this study was to evaluate the pharmacokinetics of rivastigmine following transdermal delivery by a patch versus oral delivery with conventional capsules in a population of AD patients.
  61. ncbi Colloidosomes: selectively permeable capsules composed of colloidal particles
    A D Dinsmore
    Department of Physics and DEAS, Harvard University, Cambridge, MA 02138, USA
    Science 298:1006-9. 2002
    We present an approach to fabricate solid capsules with precise control of size, permeability, mechanical strength, and compatibility...
  62. ncbi Chitosan capsules for colon-specific drug delivery: enhanced localization of 5-aminosalicylic acid in the large intestine accelerates healing of TNBS-induced colitis in rats
    Hideyuki Tozaki
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Control Release 82:51-61. 2002
    ..of this study was to achieve the colon-specific delivery of an anti-ulcerative colitis drug using chitosan capsules and to accelerate healing of 2,4,6-trinitrobenzene sulfonic acid sodium salt (TNBS)-induced colitis in rats...
  63. ncbi Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients
    G Lefevre
    Novartis Pharma AG, Basel, Switzerland
    Clin Pharmacol Ther 83:106-14. 2008
    ..Average exposure with the 10 cm2 patch was comparable to the highest capsule dose (6 mg Q12H, i.e., 12 mg/day)...
  64. ncbi Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration
    Ewart T Cole
    Capsugel Division of Pfizer, CH 4114 Hofstetten, Switzerland
    Adv Drug Deliv Rev 60:747-56. 2008
    ..Both hard and soft capsules can be considered and in each case the capsule wall may comprise gelatin or some other suitable polymer such as ..
  65. ncbi Cross-linking of hard gelatin carbamazepine capsules: effect of dissolution conditions on in vitro drug release
    Hervé Marchais
    Laboratoire de Pharmacie Galenique et Biopharmacie, ADEN UPRES EA 3234, UFR de Médecine Pharmacie, 22 Boulevard Gambetta, 76183 Rouen, France
    Eur J Pharm Sci 19:129-32. 2003
    ..enzyme and surfactant in the dissolution medium changes the in vitro drug release from cross-linked hard gelatin capsules containing a water-insoluble drug...
  66. ncbi Core-shell capsules based on supramolecular hydrogels show shell-related erosion and release due to confinement
    Mingyu Guo
    Institute for Complex Molecular Systems, and Laboratory of Chemical Biology, Eindhoven University of Technology, PO Box 513, NL 5600 MB Eindhoven, The Netherlands
    Macromol Biosci 13:77-83. 2013
    Hydrogel-containing core-shell capsules are useful as drug delivery vehicles for many biomedical applications, especially when release of incorporated guests can be controlled...
  67. ncbi Enriched cereal bars are more effective in increasing plasma quercetin compared with quercetin from powder-filled hard capsules
    Sarah Egert
    Department of Nutrition and Food Science, Nutritional Physiology, University of Bonn, Endenicher Allee 11 13, Bonn, Germany
    Br J Nutr 107:539-46. 2012
    ..to investigate the biokinetics of quercetin from quercetin-enriched cereal bars and quercetin powder-filled hard capsules. In a randomised, single-blinded, diet-controlled cross-over study, six healthy women aged 22-28 years took a ..
  68. ncbi Asymmetric membrane in membrane capsules: a means for achieving delayed and osmotic flow of cefadroxil
    Anil K Philip
    Department of Pharmaceutics, Rajiv Academy for Pharmacy, Mathura, India
    Eur J Pharm Biopharm 69:658-66. 2008
    ..The release kinetics followed the zero order and the mechanism of release was Fickian diffusion...
  69. ncbi Biocompatibility and surface structure of chemically modified immunoisolating alginate-PLL capsules
    C M Bünger
    Department of Surgery, University of Rostock, Schillingallee 35, 18055 Rostock, Germany
    J Biomed Mater Res A 67:1219-27. 2003
    ..Large-scale application of the technique, however, is hampered by insufficient biocompatibility of the capsules. A major factor in the biocompatibility of capsules is inadequate covering of the inflammatory poly-L-lysine (PLL)..
  70. ncbi Delivery by shock waves of active principle embedded in gelatin-based capsules
    Cedric Goldenstedt
    INSERM, Unit 556, 151 Cours Albert Thomas, Lyon F 69003, France
    Ultrason Sonochem 15:808-14. 2008
    ..The objective of this work was to use shock waves for delivering a molecule loaded in polymeric microcapsules...
  71. ncbi Recrystallization of bacterial S-layers on flat polyelectrolyte surfaces and hollow polyelectrolyte capsules
    Jose Luis Toca-Herrera
    Rovira i Virgili University, Department of Chemical Engineering, Campus Sescelades, Av Paisos Catalans 26, 43007 Tarragona, Spain
    Small 1:339-48. 2005
    ..Hollow capsules could also be coated in the same way, as proven by various techniques...
  72. ncbi An open-label, nonplacebo-controlled study on Cistanche tubulosa glycoside capsules (Memoregain(®)) for treating moderate Alzheimer's Disease
    Qihao Guo
    Institute of Neurology, Fudan University Huashan Affiliated Hospital, Fudan University, Shanghai, China
    Am J Alzheimers Dis Other Demen 28:363-70. 2013
    Efficacy and safety of Cistanche tubulosa glycoside capsules (CTG capsule, Memoregain(®)) for treating Alzheimer's disease (AD) were studied.
  73. ncbi [Study on the colon specific delivery of prednisolone using chitosan capsules]
    Akira Yamamoto
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, Japan
    Yakugaku Zasshi 127:621-30. 2007
    In this study, we examined the effectiveness of chitosan capsules for the colon-specific delivery of prednisolone in rats...
  74. ncbi pH-independent pulsatile drug delivery system based on hard gelatin capsules and coated with aqueous dispersion Aquacoat ECD
    Ahmad Mohamad
    College of Pharmacy, Department of Pharmaceutical Technology, Berlin, Germany
    Eur J Pharm Biopharm 64:173-9. 2006
    ..A higher coating level was required, when aqueous dispersion was used, compared to organic coatings. However, an advantageous aspect of the aqueous coating was the lower sensitivity of the lag time to a deviation in the coating level...
  75. ncbi [Effect of qiangyi jiangtang capsules on diabetes mellitus model rats]
    Xuan zhu Li
    Department of Science and Technology, Yunnan College of TCM, Kunming 650200
    Zhongguo Zhong Xi Yi Jie He Za Zhi 25:1109-11. 2005
    To study the pharmacodynamics of qiangyi jiangtang capsules (QJC) to offer the scientific foundation for clinical treatment to model rats of diabetes millitus induced by high lipid forage and streptozotocin.
  76. ncbi Remote near-IR light activation of a hyaluronic acid/poly(l-lysine) multilayered film and film-entrapped microcapsules
    D V Volodkin
    Max Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam D 14424, Germany
    ACS Appl Mater Interfaces 1:1705-10. 2009
    ..This work is aimed at layer-by-layer film-based biomedical coatings and active surfaces with light-sensitive features wherein metal NPs and microcapsules are used as active centers or carriers with remote control of functionalities...
  77. ncbi Permeability assessment of capsules for islet transplantation
    A C Powers
    Department of Medicine, Vanderbilt University Nashville, Tennessee 37232, USA
    Ann N Y Acad Sci 831:208-16. 1997
    ..These studies should assist in the design of immunoisolation devices by defining the permeability optimal for cell function and also should be applicable to any cell type or immunoisolation device...
  78. ncbi Target binding influences permeability in aptamer-polyelectrolyte microcapsules
    Yasir Sultan
    Department of Chemistry, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada
    Small 7:1219-26. 2011
    ..These results suggest that aptamer-based 'smart' responsive films and microcapsules could be applied to problems of catalysis and controlled release...
  79. ncbi Effects of HuangKui capsules on glibenclamide pharmacokinetics in rats
    Zixiu Liu
    Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China
    J Ethnopharmacol 139:1-5. 2012
    The main components of HuangKui capsules' are the total flavonoids extracted from the flowers of Abelmoschus manihot L medic. They have been widely used to treat chronic glomerulonephritis, diabetic nephropathy and nephrotic syndrome...
  80. ncbi Lyophilisomes as a new generation of drug delivery capsules
    Etienne van Bracht
    Department of Biochemistry, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Int J Pharm 439:127-35. 2012
    ..In this study, we present a drug delivery system based on a novel class of proteinaceous biodegradable nano/micro capsules, lyophilisomes. Lyophilisomes can be prepared from biomolecules without the need for amphiphilicity...
  81. ncbi Impact of rivastigmine patch and capsules on activities of daily living in Alzheimer's disease
    George Grossberg
    Department of Neurology and Psychiatry, St Louis University School of Medicine, MO, USA
    Am J Alzheimers Dis Other Demen 26:65-71. 2011
    Rivastigmine patches provide similar efficacy to rivastigmine capsules with a lower incidence of gastrointestinal side effects in patients with probable Alzheimer's disease (AD).
  82. ncbi Alginate-PLL cell encapsulation system Co-entrapping PLGA-microspheres for the continuous release of anti-inflammatory drugs
    Limor Baruch
    Faculty of Biotechnology and Food Engineering, Technion Israel Institute of Technology, Haifa, Israel
    Biomed Microdevices 11:1103-13. 2009
    ..The choice of the anti-inflammatory agent, or combination of several anti-inflammatory agents needs to be carefully optimized, as well as their release profile to achieve long- term biocompatibility...
  83. ncbi Macronutrient selection through postingestive signals in sea bass fed on gelatine capsules
    V C Rubio
    Department of Physiology, Faculty of Biology, University of Murcia, Campus de Espinardo, 30100 Murcia, Spain
    Physiol Behav 78:795-803. 2003
    ..properties on protein (P), fat (F) and carbohydrate (CH) self-selection was investigated in fish fed gelatine capsules containing pure macronutrients. A total of 40 sea bass (39.6+/-6...
  84. ncbi Evaluation of esophageal transit of tablets and capsules in 30 cats
    D S Westfall
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523, USA
    J Vet Intern Med 15:467-70. 2001
    ..The objective of this study was to evaluate the passage of tablets and capsules when given alone (dry swallow) and when followed by a water bolus (wet swallow) to determine if this could, in ..
  85. ncbi Microencapsulated hepatocytes and islets as in vivo bioartificial liver support system
    Yue Gao
    Department of General Surgery, First Clinical Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, Heilongjiang Province, China
    World J Gastroenterol 10:2067-71. 2004
    ..To confirm the xenotransplantation of microencapsulated hepatocytes and islets as a temporary bioartificial liver support system for mice with acute liver failure (ALF)...
  86. ncbi Simple and sensitive spectrofluorimetric method for the determination of pregabalin in capsules through derivatization with fluorescamine
    M I Walash
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Mansoura, 35516 Mansoura, Egypt
    Luminescence 26:342-8. 2011
    ..simple and sensitive spectrofluorimetric method has been developed for the determination of pregabalin (PG) in capsules. The method is based on the reaction between pregabalin and fluorescamine in borate buffer solution of pH 10 to ..
  87. ncbi The prophylactic effect of itraconazole capsules and fluconazole capsules for systemic fungal infections in patients with acute myeloid leukemia and myelodysplastic syndromes: a Japanese multicenter randomized, controlled study
    Yoshikazu Ito
    First Department of Internal Medicine Hematology Division, Tokyo Medical University, Tokyo, Japan
    Int J Hematol 85:121-7. 2007
    ..Our results suggest that both drugs were well tolerated in patients with AML or MDS who received chemotherapy and that the efficacy of itraconazole for prophylaxis against systemic fungal disease is not inferior to that of fluconazole...
  88. ncbi Preparation and in vitro evaluation of slow release ketoprofen microcapsules formulated into tablets and capsules
    K A el Khodairy
    Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Egypt
    J Microencapsul 9:365-73. 1992
    ..In vitro release of ketoprofen from microcapsules either filled in gelatin capsules or compressed into tablets, using calcium sulphate as diluent, confirmed the efficiency of the encapsulation ..
  89. ncbi The influence of magnesium stearate on the characteristics of mucoadhesive microspheres
    M Bogataj
    Faculty of Pharmacy, University of Ljubljana, Slovenia
    J Microencapsul 17:499-508. 2000
    ..Additionally, no correlation between the physical state of the drug in different microspheres and their biopharmaceutical properties was found...
  90. pmc The indentation of pressurized elastic shells: from polymeric capsules to yeast cells
    Dominic Vella
    Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK
    J R Soc Interface 9:448-55. 2012
    Pressurized elastic capsules arise at scales ranging from the 10 m diameter pressure vessels used to store propane at oil refineries to the microscopic polymeric capsules that may be used in drug delivery...
  91. ncbi Bone regeneration produced in rat femur defects by polymer capsules containing recombinant human bone morphogenetic protein-2
    M Isobe
    First Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Oral Maxillofac Surg 57:695-8; discussion 699. 1999
    This study examines the effect of polymer capsules containing recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone regeneration in a large segmental bone defect in the rat.
  92. ncbi A magnetically guided anti-cancer drug delivery system using porous FePt capsules
    Teruaki Fuchigami
    Department of Innovative and Engineered Materials, Tokyo Institute of Technology, Midori ku, Yokohama, Japan
    Biomaterials 33:1682-7. 2012
    ..The present article describes the fabrication of porous FePt capsules approximately 340 nm in diameter with large pores of 20 nm in an ultrathin shell of 10 nm and demonstrates their ..
  93. ncbi Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity
    Hai Yan Song
    Institute of Digestive Disease, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    J Tradit Chin Med 31:327-33. 2011
    ..whether nonalcoholic hepatic steatosis sensitizes carbon tetrachloride (CCl4)-induced liver injury, and to assess the therapeutic effect of Chinese medicine extracts of Dangfei Liganning capsules and their potential underlying mechanisms.
  94. pmc Generic delivery of payload of nanoparticles intracellularly via hybrid polymer capsules for bioimaging applications
    Haider Sami
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh, India
    PLoS ONE 7:e36195. 2012
    ..To this end, a generic approach to prepare nanomaterials-loaded polyelectrolyte multilayered (PEM) capsules has been reported, where polystyrene sulfonate (PSS)/polyallylamine hydrochloride (PAH) polymer capsules were ..
  95. ncbi Permeability and micromechanical properties of silk ionomer microcapsules
    Chunhong Ye
    School of Chemical Engineering, Nanjing Forestry University, Nanjing, Jiangsu, P R China
    Langmuir 28:12235-44. 2012
    ....
  96. ncbi Treatment of experimental septic shock with microencapsulated antisense oligomers to NF-kappaB
    Martin J D'Souza
    Southern School of Pharmacy, Mercer University, Atlanta, GA 30341, USA
    J Interferon Cytokine Res 25:311-20. 2005
    ..Microcapsule treatment using antisense to NF-kappaB suppressed TNF and IL-1 levels and mortality significantly better than all solution treatment groups in the whole blood model, endotoxic shock model, and peritonitis model...
  97. ncbi Use of texture analysis to study hydrophilic solvent effects on the mechanical properties of hard gelatin capsules
    Xiaohui Mei
    Boehringer Ingelheim Pharmaceuticals Inc, 900 Ridgebury Road, Ridgefield, CT 06877, United States
    Int J Pharm 324:128-35. 2006
    ..of the effect of hydrophilic solvent systems used as capsule fills on the mechanical properties of hard gelatin capsules. For this purpose, a texture analyzer (Stable Micro Systems, model TA...
  98. ncbi The effects of restricting publicly subsidised temazepam capsules on benzodiazepine use among injecting drug users in Australia
    Courtney L Breen
    National Drug and Alcohol Research Centre, University of New South Wales, Sydney, NSW 2052, Australia
    Med J Aust 181:300-4. 2004
    To assess the effect of a restriction on publicly subsidised temazepam 10 mg capsules upon the injection of benzodiazepines by injecting drug users (IDUs).
  99. ncbi Permeability and conductivity of red blood cell templated polyelectrolyte capsules coated with supplementary layers
    Radostina Georgieva
    Institute of Transfusion Medicine, Medical Faculty, Charite, Humboldt University Berlin, D 10098 Berlin, Germany
    Langmuir 20:1895-900. 2004
    The permeability of ions and small polar molecules through polyelectrolyte multilayer capsules templated on red blood cells was studied by means of confocal microscopy and electrorotation...
  100. ncbi Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia: a Cancer and Leukemia Group B study
    Alessandro Laviano
    Cancer 103:651-2. 2005
  101. ncbi In-vitro and in-vivo evidence of dose-dependent decrease of uropathogenic Escherichia coli virulence after consumption of commercial Vaccinium macrocarpon (cranberry) capsules
    J P Lavigne
    Institut National de la Sante et de la Recherche Medicale, ESPRI 26, Universite de Montpellier 1, UFR de Medecine, Nimes, France
    Clin Microbiol Infect 14:350-5. 2008
    This study evaluated the antibacterial efficacy of the consumption of cranberry capsules vs. placebo in the urine of healthy volunteers...

Research Grants63

  1. Stampidine: A Novel Broad-Spectrum Antiviral Agent
    Taracad Venkatachalam; Fiscal Year: 2003
    ..cats, and dogs following oral administration of formulated GMP-grade STAMP (25-100 mg/kg/day) as hard gelatin capsules showed favorable pharmacokinetics...
  2. Hematopoietic Stem Cells (HSCs) as Juvenile Protective Factors that Alter Aging
    David E Harrison; Fiscal Year: 2011
    ..defects will be tested by transplanting fetal spleens (with genetically marked cells) into recipient kidney capsules. If microenvironments are damaged with age, more endogenous HSC renewal and production of differentiated cells ..
  3. INNATE IMMUNE RESPONSE TO MICROBIAL INFECTION
    William M Nauseef; Fiscal Year: 2013
    ..tularensis produces a capsule-like material (CLM). Many bacteria produce capsules and the genes required to produce them encode proteins for transport, biosynthesis and regulation...
  4. Growth Factor and Antiapoptotic Gene Delivery to Human Islets
    Ram I Mahato; Fiscal Year: 2012
    ..to non-treated islets, transduction of islets with Adv-hHGF-hIL-1Ra prior to transplantation under the kidney capsules of NOD-SCID mice reduced blood glucose and increased the level of serum insulin and c-peptide levels upon glucose ..
  5. GENETICS AND VIRULENCE OF PNEUMOCOCCAL CAPSULAR TYPES
    JANET L YOTHER; Fiscal Year: 2012
    ..serotypes, the polymer is assembled by the Wzy-dependent mechanism, which is also used in the assembly of most capsules and exopolysaccharides produced by Gram-positive bacteria, and many capsules and lipopolysaccharide O-antigens of ..
  6. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..Participants will be randomized in a crossover trial to four daily capsules of omega-3 fatty acid supplements or to identical appearing placebos (corn oil)...
  7. Phase I Study to Evaluate Safety and Toxicity of EGCG in HIV-1-Infected Subjects
    Christina L Nance; Fiscal Year: 2011
    ..In order to achieve blinding of the study, the total number of capsules that each participant is to take will be the same (five capsules by mouth twice daily)...
  8. Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart Failure
    Terry A Lennie; Fiscal Year: 2013
    ..The intervention group will take 3 omega-3 fatty acid capsules (350 mg eicosahexaenoic acid and 50 mg docosahexaenoic acid) and consume tomato juice or other tomato-based ..
  9. An engineered meningococcal OMV vaccine for Africa against all capsular groups
    Dan M Granoff; Fiscal Year: 2013
    ..antigens identified for "group B vaccines", which also elicit protective antibodies against strains with other capsules. These "unconventional" antigens will be presented in simple outer membrane vesicles (OMV) that have potent ..
  10. Quercetin to enhance the bioavailability and activity of green tea polyphenols
    SUSANNE MARGARETE HENNING; Fiscal Year: 2013
    ..We will administer two capsules of GT extract combined with one capsule of quercetin (N=25) or with one placebo capsule (N=15) twice daily for 3 ..
  11. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..The drug has been approved by the Food and Drug Administration (FDA) (Marinol(r) soft gelatin capsules) for the treatment of nausea and vomiting associated with chemotherapy and for appetite stimulation in AIDS ..
  12. Developmental Exposure to Low-dose Bisphenol A and Human Prostate Cancer Suscepti
    Kevin P White; Fiscal Year: 2010
    ..form prostaspheres in vitro, and 2) as recombinants with rat urogenital sinus mesenchyme grafted to murine kidney capsules for 1-3 months to form chimeric prostate-like tissues in vivo...
  13. Nanocapsule-mediated topical delivery of VLP-generating Dengue DNA vaccine
    Gretchen M Unger; Fiscal Year: 2013
    ..immune effector cells in the skin via GeneSegues'(GSI's) topically administered sub-50 nanometer (s50) capsules. Third, the s50 encapsulated vaccine exploits the efficient, size-sensitive lipid raft uptake pathway to traffic ..
  14. The Effects of Docosahexaenoic acid (DHA) on fetal cardiac outcomes
    Kathleen M Gustafson; Fiscal Year: 2010
    ..DHA will be provided via algal oil capsules while the placebo group will be provided capsules containing a combination of soybean and corn oils...
  15. Development of an Oral Therapeutic Drug for Spinal and Bulbar Muscular Atrophy
    Charles C Y Shih; Fiscal Year: 2013
    ..g., capsules, tablets, syrup) will be developed...
  16. Crystallization of outer membrane proteins for export of polysaccharide capsule
    Mark A Saper; Fiscal Year: 2012
    ..b>Capsules can help bacteria evade host immune systems, promote adhesion to host cells, and form biofilms...
  17. Phase II Study of Imatinib Mesylate in Patients with Inoperable Melanoma
    Gary K Schwartz; Fiscal Year: 2010
    ..If all eligibility criteria are met, patients will be prescribed 100 milligrams of imatinib mesylate capsules and will take 4 capsules twice a day (400 mg BID) by mouth on a continual basis...
  18. The role of polysaccharide surface capsules in Bacteroides glycan degradation
    Eric C Martens; Fiscal Year: 2013
    ..The role of these capsules remains undefined, although some studies point to evasion or manipulation of host immunity...
  19. Does EPA or DHA prevent depressive symptoms in pregnancy and postpartum?
    Ellen Mozurkewich; Fiscal Year: 2011
    ..will be randomly assigned to take one of three interventions medications daily: i) 2 EPA- rich fish oil capsules ii) 2 DHA-rich fish oil capsules;or iii) 2 placebo capsules...
  20. DNA segregation during Bacillus growth and development
    JOSEPH A POGLIANO; Fiscal Year: 2013
    ..as they are often transmissible and encode antibiotic resistance and virulence traits, such as toxins and capsules. These studies could therefore help identify targets for new narrow spectrum antibiotics, since blocking plasmid ..
  21. NOVEL THERMAL REVERSIBLE POLYMER (TRG) FOR HUMAN ISLET ENCAPSULATION AND IMPLANTA
    David W Scharp; Fiscal Year: 2011
    ..long history of islet encapsulation research with hundreds of publications that define four approaches: a) micro-capsules, b) macro-capsules, c) mini-micro-capsules, and d) conformal coatings...
  22. Spin Probes in Semipermeable Nanospheres: EPR spectroscopy & imaging of tumor pH
    VALERY KHRAMTSOV; Fiscal Year: 2009
    ..into semipermeable nanospheres will be used, namely incorporation into phospholipids liposomes and polyamide capsules. (SA2) To define spectroscopic and physicochemical characteristics of pH-sensitive nanoSPINs...
  23. Capsule conjugate vaccines against ETEC and Campylobacter
    Patricia Guerry; Fiscal Year: 2013
    ..Conjugation of these ETEC proteins to C. jejuni capsules provides a novel approach to development of multivalent, broad-spectrum vaccines against two major causes of ..
  24. Bioactive Gels that Promote Long-Term Islet Survival and Function
    Kristi S Anseth; Fiscal Year: 2012
    ..Activated islet-specific T cell lines will be used in co-culture with the capsules to evaluate the immunoprotective capabilities of the PEG capsule. The biophysical properties (e.g...
  25. Molecular basis of virulence in the emerging pathogen Kingella kingae
    JOSEPH W ST. GEME; Fiscal Year: 2013
    ..kingae disease. In addition, they will provide general insights into the mechanism of interaction between encapsulated pathogens and host cells and will expand our knowledge of bacterial polysaccharide capsules.
  26. DIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sensing
    Michael T McMahon; Fiscal Year: 2013
    ..This proposal is focused on the production of micron sized CEST MR detectable alginate capsules containing both islet and mesenchymal stem cells which are appropriate for the treatment of T1DM...
  27. Lens capsule and secondary cataract
    Ram H Nagaraj; Fiscal Year: 2013
    ..In Aim 1, we will determine the relationship between cataract and AGE content in human lens capsules. In Aim 2, we will define the biochemical pathways by which capsule AGEs influence epithelial cell adhesion, ..
  28. Nonviral vehicles targeting liver cell-subtypes for nuclear delivery via rafts
    Gretchen M Unger; Fiscal Year: 2010
    ..GeneSegues, Inc. (GSI) has developed a nonviral delivery technology, sub-50 nanometer (s50) capsules, which co-opt the raft/caveolar uptake path for efficient intracellular delivery of NA drugs...
  29. Fractal Identification System for Medication
    ADAM HANINA; Fiscal Year: 2012
    ..self-similarity properties of fractals to encode and print unique secure fractal patterns directly onto pills or capsules. This SBIR Phase I will allow technical feasibility of this solution, Fractal-ID", to be demonstrated and will ..
  30. Cranberry Capsules for Prevention of UTI in Nursing Home Residents
    Manisha Juthani-Mehta; Fiscal Year: 2013
    ..The primary aim of this study is to test the efficacy of two oral cranberry capsules per day for prevention of bacteriuria plus pyuria in female nursing home residents...
  31. Identifying a Hypoxia Inducible Factor target profile in Renal Cell Carcinoma tum
    Alexandra Arreola; Fiscal Year: 2013
    ..After which, these cells will be reintroduced to their native environment, renal capsules of immunocompromised mice, to study their tumorigenic potential...
  32. Assessing Clinical Equivalence for Generic Drugs Approved By Innovative Methods
    Aaron Seth Kesselheim; Fiscal Year: 2013
    ..the approval of generic venlafaxine ER, calcitonin salmon nasal spray, enoxaparin, acarbose, vancomycin capsules, and sodium ferric gluconate...
  33. Epithelial Progenitor Cells in Lung Repair and Regeneration
    Matthew F Krummel; Fiscal Year: 2013
    ..3) Analyze and further develop a novel, single cell in vivo lung organoid assay in kidney capsules in order to optimize the capacity of adult epithelial progenitor cells to generate functional respiratory units ..
  34. Reduction in medication administration and charting errors in nursing facilities
    ALAN J JACOBS; Fiscal Year: 2013
    ..is a novel bench top system capable of determining the composition and dosage of individual pills, tablets and capsules in real-time...
  35. A Translational Model of Mood-Based Drug Abuse
    Cassandra D Gipson; Fiscal Year: 2010
    ..a FR-100 schedule in a terminal component, and will receive money (study 2a) or points that can be exchanged for capsules of d-amphetamine (study 2b)...
  36. Tissue Engineered Repair of Cranial Facial Muscle
    EMILY LYNN ONGSTAD; Fiscal Year: 2013
    ..myofibroblast differentiation and preserves underlying muscle in rodent and porcine models of implant contraction capsules - all effects which appear to be antagonistic of TGF[unreadable] signaling...
  37. Cranberry as a Strategy for Preventing CAUTI Post Gynecologic Surgery
    Betsy Foxman; Fiscal Year: 2011
    ..Our overall goal is to determine the effect of taking cranberry capsules on reducing the rate of post operatory CAUTI among surgical gynecological patients...
  38. Dose-response of cranberry in women with recurrent UTIs
    Lynn Stothers; Fiscal Year: 2010
    ..with prolonged or high levels of cranberry consumption This study is a dose-response trial of cranberry tablets/capsules, comparing the efficacy of 5 dose levels: placebo, very low dose, low dose, medium dose and high dose...
  39. A Photo-triggered on-demand drug delivery system for chronic pain
    BRIAN PAUL TIMKO; Fiscal Year: 2012
    ..Finally, we will incorporate this membrane into drug reservoir capsules, and assess the ability of the device to locally deliver anesthesia at the sciatic nerve in a rat model...
  40. PillStream: Agile High-Throughput Assembly of Custom Multi-Medication Packaging
    EDWARD ACWORTH; Fiscal Year: 2013
    ..9% placement accuracy for surrogate pills and gelatin capsules while exceeding our target fill rate (100 blisters/min) by 50%. Specific Aims...
  41. Generation of hPSCs Using Reprogramming Proteins-Encapsulated Nanoparticles
    Hsian Rong Tseng; Fiscal Year: 2012
    ..1) We will synthesize a variety of polymer building blocks, cross linkers, functional ligands, as well as, nano- capsules containing the four reprogramming TFs for self-assembly of SNP-based delivery vectors...
  42. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    GREGORY RAY ZIEGLER; Fiscal Year: 2012
    ..These products will be an adaptation of current softgel capsule technology. However, unlike current gelatin capsules, we will develop a range of non-gelatin capsules varying in shape and firmness (texture)...
  43. Designing Optimal Microbicide Delivery Integrating Rheology and Acceptability
    JOHN EDWARD HAYES; Fiscal Year: 2013
    ..These products will be an adaptation of current softgel capsule technology. However, unlike current gelatin capsules, we will develop a range of non-gelatin capsules varying in shape and firmness (texture)...
  44. Host Response in S. aureus Infections: Role of T cells
    Arthur Tzianabos; Fiscal Year: 2006
    ..Based on these data, we hypothesize that CD4+ T cells activated by S. aureus capsules are critical in determining the outcome of staphylococcal infections through the release of CXC chemokines that ..
  45. Anti-HIV-1 Composite Cellulose Acetate Phthalate Film
    Shibo Jiang; Fiscal Year: 2006
    Cellulose acetate phthalate (CAP), used in the pharmaceutical industry for enteric film coating of tablets and capsules, is an HIV-1 entry inhibitor blocking the CXCR4/CCR5 coreceptor binding sites on the virus and eliciting "dead-end" ..
  46. ROLE OF CHLORIDE IN SODIUM-DEPENDENT HYPERTENSION
    Theodore Kurtz; Fiscal Year: 1990
    ..studies in humans with essential hypertension, we will determine whether supplementing a low NaC1 diet with capsules containing sodium citrate, or a combination of sodium bicarbonate, sodium ascorbate, and sodium phosphate, ..
  47. Next Generation Capsule Endoscopy Video Data Acquisition and Visualization Platfo
    STEVEN YI; Fiscal Year: 2011
    ..close to 1 million patients worldwide have gone through capsule endoscopy procedures using their PillCam capsules. Capsule endoscopy is a rapidly-growing multi-billion dollar market...
  48. An Intelligent Capsule Endoscopy Video Analysis Software Platform
    STEVEN YI; Fiscal Year: 2013
    ..more than one million patients worldwide have gone through capsule endoscopy procedure using their PillCam capsules. Capsule endoscopy is a rapidly-growing multi-billion dollar market (predicted to reach billion dollar mark in ..
  49. Capsule regulatory network in S. aureus pathogenesis
    Chia Y Lee; Fiscal Year: 2013
    ..Because of their predominance these capsules have been the prime components for vaccine development...
  50. Anti-HIV Microbicide: Cellulose Acetate Phthalate (CAP)
    A Robert Neurath; Fiscal Year: 2004
    ..acetate phthalate (CAP) has been used as an enteric film coating material or as a matrix binder for tablets and capsules. It is widely used in oral pharmaceutical products and is generally regarded as a nontoxic material free of ..
  51. KINEMATICS AND STABILITY OF THE ARCH OF THE FOOT
    Harold Kitaoka; Fiscal Year: 2001
    ..The arch is constrained by bony and articular geometry, ligaments, joint capsules, and fascia...
  52. ENDOMETRIAL VEGF: ENDOCRINE REGULATION OF ANGIOGENESIS
    Robert Taylor; Fiscal Year: 1999
    ..associated with depot medroxyprogesterone acetate (DMPA) injections and levonorgestrel- containing silastic capsules (Norplant)...
  53. Functionalized, Nanoscale Coatings for Islet Encapsulation
    Cherie L Stabler; Fiscal Year: 2011
    ..By developing stable capsules on the order of 1000-fold smaller than standard practices via controlled covalent linking of individual polymers ..
  54. ARIZONA CENTER FOR PHYTOMEDICINE RESEARCH (ACPRX)
    Janet Funk; Fiscal Year: 2004
    ..absolute oral bioavailability, rates of absorption) of commercial formulations (as a function dose) as well as capsules containing pure chemical and active components...
  55. 2D/3D HYBRID TECHNOLOGY AND SOFTWARE SYSTEM FOR DETECTION OF ABNORMALITIES FROM C
    JAMES Z WEN; Fiscal Year: 2011
    ..more than 820,000 patients worldwide have gone through capsule endoscopy procedure using their PillCam capsules. Capsule endoscopy is a rapidly-growing million-dollar market...
  56. Nanovalve Platform: Targeted, Controlled, Release of Anticancer Drugs
    Jeffrey I Zink; Fiscal Year: 2013
    ..The assembly is coated with molecules or proteins that target the capsules to cancer cells...
  57. Smart Capsule for Automatic Adherence Monitoring
    GLEN FLORES; Fiscal Year: 2013
    ..This Fast-track SBIR project will utilize eTect's existing technology to create Smart Capsules that provide accurate and real-time adherence monitoring for clinical studies, particularly studies at high risk ..
  58. NRI: Personal Pill Sized Soft Medical Robots for the Gastrointestinal Tract
    Metin Sitti; Fiscal Year: 2013
    ..However, such robotic capsules are not available yet for any clinical or personal use yet due to challenges in their actuation, locomotion, ..
  59. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    ..a vegetable oil control. They will receive 12, 1-gm capsules of the oils per day for 2, randomly assigned, 6-week periods...
  60. Visualization and real-time dosimetry for prostate brachytherapy using ultrasound
    Septimiu Salcudean; Fiscal Year: 2007
    ..This treatment involves the permanent placement of radioactive capsules (seeds) in the prostate, in a pattern that delivers a sufficient radiation dose to kill the cancer while ..
  61. Memory effects of stimulant drugs in humans
    Harriet de Wit; Fiscal Year: 2013
    ..Subjects will receive capsules containing AMP (20 mg) or placebo before encoding or retrieval in all four combinations...
  62. Nutrition Intervention: Metabolic Complications of HIV+
    Margo Woods; Fiscal Year: 2006
    ..0 g of omega 3-fatty acids from capsules to give a total of 6 g/day of omega 3-fatty acids and a ratio of n-6/n-3 of 4:1...
  63. BACTEROIDES FRAGILIS CAPSULES--SYNTHESIS AND VIRULENCE
    Arthur Tzianabos; Fiscal Year: 1999
    ..This research will expand our understanding of how bacteria promote abscess formation in the peritoneal cavity and may lead to better therapeutic measures to prevent or treat this disease process. ..