vitamin k 2

Summary

Summary: A group of substances similar to VITAMIN K 1 which contains a ring of 2-methyl-1,4-naphthoquinione and an isoprenoid side chain of varying number of isoprene units. In vitamin K 2, each isoprene unit contains a double bond. They are produced by bacteria including the normal intestinal flora.

Top Publications

  1. pmc The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool
    Martijn Bekker
    Swammerdam Institute for Life Sciences Molecular Microbial Physiology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Bacteriol 192:746-54. 2010
  2. pmc Ubiquinone and menaquinone electron carriers represent the yin and yang in the redox regulation of the ArcB sensor kinase
    Adrian F Alvarez
    Departamento de Genetica Molecular, Instituto de Fisiologia Celular Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Bacteriol 195:3054-61. 2013
  3. ncbi An alternative menaquinone biosynthetic pathway operating in microorganisms
    Tomoshige Hiratsuka
    Biotechnology Research Center, Toyama Prefectural University, Toyama 939 0398, Japan
    Science 321:1670-3. 2008
  4. ncbi The anticancer effects of vitamin K
    Davis W Lamson
    Coordinator of Oncology, Bastyr University, Kenmore, Washington, USA
    Altern Med Rev 8:303-18. 2003
  5. ncbi Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
  6. ncbi On the function of the various quinone species in Escherichia coli
    Poonam Sharma
    Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    FEBS J 279:3364-73. 2012
  7. pmc Diversity of the early step of the futalosine pathway
    Chisato Arakawa
    Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan
    Antimicrob Agents Chemother 55:913-6. 2011
  8. ncbi Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Nature 468:117-21. 2010
  9. ncbi High dietary menaquinone intake is associated with reduced coronary calcification
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 203:489-93. 2009
  10. ncbi Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
    Sarah Cockayne
    York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, England
    Arch Intern Med 166:1256-61. 2006

Research Grants

Detail Information

Publications250 found, 100 shown here

  1. pmc The ArcBA two-component system of Escherichia coli is regulated by the redox state of both the ubiquinone and the menaquinone pool
    Martijn Bekker
    Swammerdam Institute for Life Sciences Molecular Microbial Physiology, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    J Bacteriol 192:746-54. 2010
    ..coli is modulated by the redox state of the menaquinone pool and that the ubiquinone/ubiquinol ratio in vivo surely is not the only determinant of ArcB activity...
  2. pmc Ubiquinone and menaquinone electron carriers represent the yin and yang in the redox regulation of the ArcB sensor kinase
    Adrian F Alvarez
    Departamento de Genetica Molecular, Instituto de Fisiologia Celular Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Bacteriol 195:3054-61. 2013
    ..Thus, an essential link in the Arc signal transduction pathway connecting the redox state of the quinone pool to the transcriptional apparatus is elucidated...
  3. ncbi An alternative menaquinone biosynthetic pathway operating in microorganisms
    Tomoshige Hiratsuka
    Biotechnology Research Center, Toyama Prefectural University, Toyama 939 0398, Japan
    Science 321:1670-3. 2008
    ..As humans and commensal intestinal bacteria, including lactobacilli, lack this pathway, it represents an attractive target for the development of chemotherapeutics...
  4. ncbi The anticancer effects of vitamin K
    Davis W Lamson
    Coordinator of Oncology, Bastyr University, Kenmore, Washington, USA
    Altern Med Rev 8:303-18. 2003
    ..Tyrosine kinases associated with cyclins have also been shown to be affected by vitamin K, which can lead to cell cycle arrest and cell death...
  5. ncbi Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
    ..In humans, MK-7 has a greater efficacy than phylloquinone in carboxylating both liver and bone Gla proteins. A daily supplement of phylloquinone has shown potential for improving anticoagulation control...
  6. ncbi On the function of the various quinone species in Escherichia coli
    Poonam Sharma
    Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands
    FEBS J 279:3364-73. 2012
    ..Furthermore, we demonstrate that demethylmenaquinone serves as an electron acceptor for oxidation of succinate to fumarate, and that all three quinol oxidases of E. coli accept electrons from this naphtoquinone derivative...
  7. pmc Diversity of the early step of the futalosine pathway
    Chisato Arakawa
    Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan
    Antimicrob Agents Chemother 55:913-6. 2011
    ..Therefore, this step is potentially an attractive target for the development of specific anti-H. pylori drugs...
  8. ncbi Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme
    Kimie Nakagawa
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Nature 468:117-21. 2010
    ..Our results show that UBIAD1 is a human MK-4 biosynthetic enzyme; this identification will permit more effective decisions to be made about vitamin K intake and bone health...
  9. ncbi High dietary menaquinone intake is associated with reduced coronary calcification
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 203:489-93. 2009
    ..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both...
  10. ncbi Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials
    Sarah Cockayne
    York Trials Unit, Department of Health Sciences, University of York, York YO10 5DD, England
    Arch Intern Med 166:1256-61. 2006
    ..Observational and some experimental data suggest that low intake of vitamin K may be associated with an increased risk of fracture...
  11. ncbi Four novel Arthrobacter species isolated from filtration substrate
    Linxian Ding
    Hirose Laboratory Environmental Microorganism, Honcho, Funabashi City, Chiba Pref 4 43 20, Japan
    Int J Syst Evol Microbiol 59:856-62. 2009
    ..nov. (type strain LC10(T)=IAM 15385(T)=CCTCC AB 206017(T)) and Arthrobacter albidus sp. nov. (type strain LC13(T)=IAM 15386(T)=CCTCC AB 206018(T)) are proposed...
  12. ncbi An alternative menaquinone biosynthetic pathway operating in microorganisms: an attractive target for drug discovery to pathogenic Helicobacter and Chlamydia strains
    Tohru Dairi
    Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan
    J Antibiot (Tokyo) 62:347-52. 2009
    ..As humans and some useful intestinal bacteria, such as lactobacilli, lack the alternative pathway, it would be an attractive target for the development of chemotherapeutics...
  13. ncbi Involvement of hepatoma-derived growth factor in the growth inhibition of hepatocellular carcinoma cells by vitamin K(2)
    Teruhisa Yamamoto
    Division of Hepatobiliary and Pancreatic Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, 663 8501, Japan
    J Gastroenterol 44:228-35. 2009
    ..We investigated the regulation of HDGF expression by vitamin K(2)...
  14. ncbi Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: the Rotterdam Study
    Johanna M Geleijnse
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    J Nutr 134:3100-5. 2004
    ..71 (0.50, 1.00) and 0.48 (0.32, 0.71), respectively]. Phylloquinone intake was not related to any of the outcomes. These findings suggest that an adequate intake of menaquinone could be important for CHD prevention...
  15. ncbi Menaquinone biosyntheses in microorganisms
    Tohru Dairi
    Graduate School of Engineering, Hokkaido University, Hokkaido, Japan
    Methods Enzymol 515:107-22. 2012
    ..In the case of the former two strains, AFL was converted to FL by deaminases then to DHFL. In contrast, AFL was directly converted to DHFL in H. pylori...
  16. ncbi Quinones as the redox signal for the arc two-component system of bacteria
    D Georgellis
    Department of Microbiology and Molecular Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Science 292:2314-6. 2001
    ..Thus, the Arc signal transduction system provides a link between the electron transport chain and gene expression...
  17. pmc Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
    Angela M Cheung
    Department of Medicine, Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 5:e196. 2008
    ..This study was conducted to determine whether daily high-dose vitamin K1 supplementation safely reduces bone loss, bone turnover, and fractures...
  18. ncbi A high menaquinone intake reduces the incidence of coronary heart disease
    G C M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Nutr Metab Cardiovasc Dis 19:504-10. 2009
    ..Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD...
  19. ncbi Vitamin K2 suppresses proliferation and motility of hepatocellular carcinoma cells by activating steroid and xenobiotic receptor
    Kotaro Azuma
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Endocr J 56:843-9. 2009
    ..These results suggest that the activation of SXR could contribute to tumor suppressive effects of vitamin K2 on HCC cells...
  20. ncbi Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats
    H M H Spronk
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, University of Maastricht, Maastricht, The Netherlands
    J Vasc Res 40:531-7. 2003
    ....
  21. ncbi Role of vitamin K2 in the development of hepatocellular carcinoma in women with viral cirrhosis of the liver
    Daiki Habu
    Department of Hepatology, Graduate School of Medicine, Osaka City University, Osaka, Japan
    JAMA 292:358-61. 2004
    ..Previous findings indicate that vitamin K2 (menaquinone) may play a role in controlling cell growth...
  22. ncbi Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7
    Leon J Schurgers
    VitaK and Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands
    Blood 109:3279-83. 2007
    ..MK-7 induced more complete carboxylation of osteocalcin, and hematologists should be aware that preparations supplying 50 mug/d or more of MK-7 may interfere with oral anticoagulant treatment in a clinically relevant way...
  23. ncbi Menatetrenone, a vitamin K2 analogue, inhibits hepatocellular carcinoma cell growth by suppressing cyclin D1 expression through inhibition of nuclear factor kappaB activation
    Iwata Ozaki
    Division of Hepatology and Metabolism, Department of Internal Medicine, and Health Administration Center, Saga Medical School, Saga University, Nabeshima, Saga, Japan
    Clin Cancer Res 13:2236-45. 2007
    ..However, the mechanisms by which vitamin K2 inhibits HCC cell growth have not bee fully clarified, and we therefore investigated the molecular basis of vitamin K2-induced growth inhibition of HCC cells...
  24. ncbi Effects of vitamin K2 on osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Curr Pharm Des 10:2557-76. 2004
    ..No randomized well-controlled prospective studies conducted on a sufficiently large number of patients have been reported yet, therefore, further studies are needed to confirm the efficacy of vitamin K2 in the treatment of osteoporosis...
  25. pmc A C-methyltransferase involved in both ubiquinone and menaquinone biosynthesis: isolation and identification of the Escherichia coli ubiE gene
    P T Lee
    Department of Chemistry and Biochemistry, Molecular Biology Institute, University of California, Los Angeles 90095 1569, USA
    J Bacteriol 179:1748-54. 1997
    ..The data presented identify the E. coli UbiE polypeptide and provide evidence that it is required for the C methylation reactions in both ubiquinone and menaquinone biosynthesis...
  26. ncbi Catalytic mechanism of SHCHC synthase in the menaquinone biosynthesis of Escherichia coli: identification and mutational analysis of the active site residues
    Ming Jiang
    Department of Chemistry, Center for Cancer Research, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    Biochemistry 48:6921-31. 2009
    ....
  27. ncbi Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nutr Rev 64:509-17. 2006
    ..Thus, available evidence supports an effect of menatetrenone on bone quality during osteoporosis treatment...
  28. ncbi Conversion of phylloquinone (Vitamin K1) into menaquinone-4 (Vitamin K2) in mice: two possible routes for menaquinone-4 accumulation in cerebra of mice
    Toshio Okano
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1, Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    J Biol Chem 283:11270-9. 2008
    ....
  29. pmc Respiration and growth of Shewanella oneidensis MR-1 using vanadate as the sole electron acceptor
    Wesley Carpentier
    Laboratory of Protein Biochemistry and Protein Engineering, UGent, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    J Bacteriol 187:3293-301. 2005
    ..coli ccm genes being functional in another organism. Analysis of an mtrB-deficient mutant confirmed the results of a previous paper indicating that OmcB may function as a vanadate reductase or may be part of a vanadate reductase complex...
  30. ncbi Differences in protonation of ubiquinone and menaquinone in fumarate reductase from Escherichia coli
    Elena Maklashina
    Molecular Biology Division, Veterans Affairs Medical Center, San Francisco, California, 94121, USA
    J Biol Chem 281:26655-64. 2006
    ..These findings represent an example of how enzymes that are designed to accommodate either UQ or MQ at a single Q binding site may nevertheless develop sufficient plasticity at the binding pocket to react differently with MQ and UQ...
  31. ncbi Preventive effects of vitamin K on recurrent disease in patients with hepatocellular carcinoma arising from hepatitis C viral infection
    Satoru Kakizaki
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan
    J Gastroenterol Hepatol 22:518-22. 2007
    ..In this study, the chemopreventive effects of vitamin K2 on the recurrence and survival of patients with HCC after curative therapy were evaluated...
  32. ncbi Lysine 190 is the catalytic base in MenF, the menaquinone-specific isochorismate synthase from Escherichia coli: implications for an enzyme family
    Subramaniapillai Kolappan
    Department of Pharmacological Sciences and Center for Structural Biology, Stony Brook University, Stony Brook, New York 11794 5115, USA
    Biochemistry 46:946-53. 2007
    ..The studies reported here extend the mechanism recently proposed for this enzyme family by He et al.: He, Z., Stigers Lavoie, K. D., Bartlett, P. A., and Toney, M. D. (2004) J. Am. Chem. Soc. 126, 2378-85...
  33. ncbi Spirosoma rigui sp. nov., isolated from fresh water
    Keun Sik Baik
    Department of Biology, College of Natural Sciences, Sunchon National University, Suncheon 540 742, Republic of Korea
    Int J Syst Evol Microbiol 57:2870-3. 2007
    ..Strain WPCB118(T) represents a novel species of the genus Spirosoma, for which the name Spirosoma rigui sp. nov. is proposed. The type strain is WPCB118(T) (=KCTC 12531(T)=NBRC 101117(T))...
  34. ncbi Effect of vitamin K2 on the recurrence in patients with hepatocellular carcinoma
    Naoki Hotta
    Department of Internal Medicine, Division of Gastroenterology, Aichi Medical University School of Medicine, Aichi, Japan
    Hepatogastroenterology 54:2073-7. 2007
    ..Forty-five patients with cured or possibly cured HCC were randomly selected, assigning patients to treatment (n=21) or control group (n=24) with randomization list...
  35. ncbi Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate
    J Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    J Orthop Sci 6:487-92. 2001
    ....
  36. ncbi Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet
    M Kobayashi
    Pharmacological Evaluation Section, Department of Applied Drug Research, Eisai Co, Ltd, Bunkyo, Tokyo 112 8088, Japan
    Bone 35:1136-43. 2004
    ..Our results from this model suggest that MK-4 and ALN affect bone mechanical properties by different mechanisms...
  37. ncbi Simple menaquinones reduce carbon tetrachloride and iron (III)
    Q Shiang Fu
    Department of Civil and Environmental Engineering, Stanford University, Stanford, CA 94305 4020, USA
    Biodegradation 20:109-16. 2009
    ..The results indicate that molecules within the menaquinone family may contribute to both the extracellular and cell-associated reduction of carbon tetrachloride and iron (III)...
  38. ncbi The effect of menatetrenone, a vitamin K2 analog, on disease recurrence and survival in patients with hepatocellular carcinoma after curative treatment: a pilot study
    Toshihiko Mizuta
    Department of Internal Medicine, Saga Medical School, Japan
    Cancer 106:867-72. 2006
    ..In the current study, the authors tested the effects of menatetrenone, a vitamin K2 analog, on recurrent HCC and survival after curative treatment...
  39. ncbi Differential effects of two growth inhibitory K vitamin analogs on cell cycle regulating proteins in human hepatoma cells
    Judith Markovits
    Division of Cancer Research, Institute of Biomedical Sciences, Academia Sinica, 115, Taipei, Taiwan, ROC
    Life Sci 72:2769-84. 2003
    ..Tumors expressing high levels of oncogenic Cdc25A phosphatase may thus be susceptible to the growth inhibitory activities of this class of compound...
  40. pmc Menaquinone-4 enhances testosterone production in rats and testis-derived tumor cells
    Asagi Ito
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Lipids Health Dis 10:158. 2011
    ..In this study, we investigated the function of vitamin K in the testis and analyzed its role in steroidogenesis...
  41. ncbi Effect of menatetrenone, a vitamin k2 analog, on recurrence of hepatocellular carcinoma after surgical resection: a prospective randomized controlled trial
    Mitsuru Ishizuka
    Department of Gastroenterological Surgery, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Anticancer Res 32:5415-20. 2012
    ..0%, respectively, while those in the MNT group were 78.3%, 58.1%, and 31.0%, respectively (p=0.060). MNT has a moderately suppressive effect on HCC recurrence after hepatectomy, especially in patients with a normal preoperative DCP level...
  42. ncbi Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures
    Y Takeuchi
    Division of Endocrinology, Department of Medicine, University of Tokyo School of Medicine, Tokyo, Japan
    Bone 27:769-76. 2000
    ..Therefore, MK4 may favor bone metabolism to spare bone mass as a compound that modulates cellular differentiation and functions in bone marrow in addition to as a nutrient factor...
  43. ncbi Induction of apoptosis in hepatocellular carcinoma Smmc-7721 cells by vitamin K(2) is associated with p53 and independent of the intrinsic apoptotic pathway
    Lu Li
    Department of Biochemistry and Molecular Biology, Wannan Medical College, Wuhu, Anhui Province, People s Republic of China
    Mol Cell Biochem 342:125-31. 2010
    ..In summary, these data suggested that VK(2) can inhibit the growth of Smmc-7721 cells by induction of apoptosis involving caspase 8 activation and p53. This apoptotic process was not mediated by the intrinsic apoptotic pathway...
  44. pmc A bicarbonate cofactor modulates 1,4-dihydroxy-2-naphthoyl-coenzyme a synthase in menaquinone biosynthesis of Escherichia coli
    Ming Jiang
    Department of Chemistry, State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 285:30159-69. 2010
    ....
  45. ncbi Crystal structure of Mycobacterium tuberculosis MenB, a key enzyme in vitamin K2 biosynthesis
    James J Truglio
    Department of Pharmacological Sciences, Center for Structural Biology, State University of New York at Stony Brook, NY 11794 5115, USA
    J Biol Chem 278:42352-60. 2003
    ..Knowledge of the active site geometry and characterization of the catalytic mechanism of MenB will aid in identifying new inhibitors for this potential drug target...
  46. ncbi Vitamin K2: a novel therapy for osteoporosis
    Ram Prabhoo
    Department of Orthopaedics, VN Desa Municipal Hospital, Mumbai 400055
    J Indian Med Assoc 108:253-4, 256-8. 2010
    ..Article covers effect of vitamin K2 on bone homeostasis and its safety in children, hepatic and renal impairment. Vitamin K2 should be considered for prevention and treatment in those conditions known to contribute to osteoporosis...
  47. ncbi Determination of the stereochemistry of 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate, a key intermediate in menaquinone biosynthesis
    Ming Jiang
    Department of Chemistry, Center for Cancer Research, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    Org Lett 9:4765-7. 2007
    ..Structural determination of this key intermediate represents a critical step to complete elucidation of the biosynthetic pathway...
  48. pmc Role of menaquinones in Fe(III) reduction by membrane fractions of Shewanella putrefaciens
    Daad A Saffarini
    Department of Biological Sciences, University of Wisconsin Milwaukee, 3209 N Maryland Ave, Milwaukee, WI 53211, USA
    J Bacteriol 184:846-8. 2002
    ..These results indicate that menaquinones are essential components for the reduction of Fe(III) by both whole cells and purified membrane fractions when formate or lactate is used as the electron donor...
  49. ncbi Effect of vitamin K2 on the development of hepatocellular carcinoma in type C cirrhosis
    Kazuo Kojima
    Department of Gastroenterology, Dokkyo Medical University, 880 Kitakobayashi, Mibu machi, Shimotsuga gun, Tochigi 321 0293, Japan
    Hepatogastroenterology 57:1264-7. 2010
    ..We therefore examined whether menatetrenone could prevent the development of hepatocellular carcinoma in patients with type C cirrhosis...
  50. ncbi Vitamin K2 inhibits the growth of hepatocellular carcinoma via decrease of des-gamma-carboxy prothrombin
    Meng Ma
    Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, Jinan, China
    Chemotherapy 55:28-35. 2009
    ..Serum and tissue DCP expressions are thought to reflect the biological malignant potential of HCC. Hence, we aimed to examine the efficacy of vitamin K(2) on the production of DCP as well as tumor cell growth and invasion...
  51. ncbi Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats
    Y Asawa
    Division of Anatomy and Cell Biology of the Hard Tissue, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Bone 35:870-80. 2004
    ..Thus, MK-4 appears to target osteoblasts, consequently inhibiting bone loss induced by ovariectomy...
  52. pmc Mechanism of the intramolecular Claisen condensation reaction catalyzed by MenB, a crotonase superfamily member
    Huei Jiun Li
    Institute for Chemical Biology and Drug Discovery and Department of Chemistry, Stony Brook University, Stony Brook, New York 11794, United States
    Biochemistry 50:9532-44. 2011
    ..This work reinforces the utility of using a stable substrate analogue as a mechanistic probe in which only one atom has been altered leading to a decrease in α-proton acidity...
  53. ncbi Olive oil supplemented with menaquinone-7 significantly affects osteocalcin carboxylation
    Francesca Bruge
    Department of Biochemistry, Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy
    Br J Nutr 106:1058-62. 2011
    ..We conclude that regular consumption of MK-7-enriched olive oil may constitute a valid approach in order to preserve some key biochemical mechanisms controlling bone mineralisation...
  54. ncbi Stabilization of the second oxyanion intermediate by 1,4-dihydroxy-2-naphthoyl-coenzyme A synthase of the menaquinone pathway: spectroscopic evidence of the involvement of a conserved aspartic acid
    Minjiao Chen
    Department of Chemistry and State Key Laboratory for Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    Biochemistry 50:5893-904. 2011
    ..Their involvement in the interaction with the small molecule ligands suggests that the disordered loop is folded in interaction with the substrates or reaction intermediates, supporting an induced-fit catalytic mechanism for the enzyme...
  55. ncbi Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease
    Yoshihiro Sato
    Department of Neurology, Mitate Hospital, Tagawa 826 0041, Japan
    Bone 36:61-8. 2005
    ..0003; odds ratio = 7.5). Treatment with MK-4 and vitamin D2 with calcium supplements increases the BMD in elderly female patients with AD and leads to the prevention of nonvertebral fractures...
  56. ncbi Apoptosis of liver cancer cells by vitamin K2 and enhancement by MEK inhibition
    Kazuya Matsumoto
    Second Department of Internal Medicine, Tottori University School of Medicine, Yonago, Tottori 683 8504, Japan
    Int J Oncol 29:1501-8. 2006
    ..These data demonstrated that VK2 induced apoptosis and activated the MEK/ERK1/2 signaling pathway in a cell-type specific manner, and a MEK inhibitor could augment the cell death in these cells...
  57. ncbi Difference in the metabolism of vitamin K between liver and bone in vitamin K-deficient rats
    Toshiro Sato
    Chemicals Research Laboratories, Honen Corporation, Iwata gun, Shizuoka, Japan
    Br J Nutr 87:307-14. 2002
    ..Furthermore, the counteracting effect of MK-7 on prolonged PT in vitamin K-deficient rats was found to be higher than phylloquinone or MK-4...
  58. ncbi Vitamin K2 augments 5-fluorouracil-induced growth inhibition of human hepatocellular carcinoma cells by inhibiting NF-κB activation
    Hao Zhang
    Department of Surgery, The First Affiliated Hospital, China Medical University, Shenyang, P R China
    Oncol Rep 25:159-66. 2011
    ..VK2 inhibited 5-FU-induced NF-κB activation and cyclin D1 expression. Therefore, combination of VK2 and 5-FU might represent a new therapeutic strategy for patients with HCC...
  59. pmc Stable analogues of OSB-AMP: potent inhibitors of MenE, the o-succinylbenzoate-CoA synthetase from bacterial menaquinone biosynthesis
    Xuequan Lu
    Molecular Pharmacology and Chemistry Program and Tri Institutional Research Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Chembiochem 13:129-36. 2012
    ..A pH-dependent interconversion of the free keto acid and lactol forms of the inhibitors is also described, along with implications for inhibitor design...
  60. ncbi Vitamin K2 inhibits the growth and invasiveness of hepatocellular carcinoma cells via protein kinase A activation
    Motoyuki Otsuka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 40:243-51. 2004
    ..In conclusion, similar to an acyclic retinoid--which was previously reported to prevent the recurrence of HCC--vitamin K(2), another lipid-soluble vitamin, may be a promising therapeutic means for the management of HCC...
  61. ncbi Hepatocellular carcinoma and vitamin K
    Toshihiko Mizuta
    Department of Internal Medicine, Saga Medical School, 5 1 1 Nabeshima, Saga, Japan
    Vitam Horm 78:435-42. 2008
    ..Our laboratory findings revealed that the inhibitory effect of vitamin K2 against HCC cell growth was generated by suppressing cyclin D1 expression through inhibition of NF-kappaB activation...
  62. ncbi Elucidation of the mechanism producing menaquinone-4 in osteoblastic cells
    Yoshitomo Suhara
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Bioorg Med Chem Lett 19:1054-7. 2009
    ..In this study, we studied the mechanism of MK-4's conversion with chemical techniques using deuterated analogues...
  63. ncbi The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children
    Marieke J H van Summeren
    Department of Paediatrics, University Medical Centre Utrecht, PO Box 85090, 3508 AB Utrecht, The Netherlands
    Br J Nutr 102:1171-8. 2009
    ..These findings demonstrate that in healthy, prepubertal children, modest supplementation with MK-7 increases circulating concentrations of MK-7 and increases osteocalcin carboxylation...
  64. ncbi Combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma
    Hitoshi Yoshiji
    Third Department of Internal Medicine, Nara Medical University, Shijo cho 840, Kashihara, Nara 634 8522, Japan
    J Hepatol 51:315-21. 2009
    ....
  65. ncbi Identification and characterization of (1R,6R)-2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase in the menaquinone biosynthesis of Escherichia coli
    Ming Jiang
    Department of Chemistry, Center for Cancer Research, The Hong Kong University of Science and Technology HKUST, Clear Water Bay, Kowloon, Hong Kong Special Administrative Region SAR, China
    Biochemistry 47:3426-34. 2008
    ..These results show that the SHCHC synthase is closely related to alpha/beta hydrolases but catalyzes a reaction mechanistically distinct from all known hydrolase reactions...
  66. ncbi Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells
    Chi Kwan Tsang
    Marine and Highland Bioscience Center, Saga University, 152 1 Shonan cho, Karatsu, 847 0021, Saga, Japan
    Neurosci Lett 323:9-12. 2002
    ..These results suggest that the K vitamins enhance neurite outgrowth via the activation of PKA and MAPK-mediated signaling pathways in PC12D cells...
  67. ncbi Design and synthesis of biologically active analogues of vitamin K2: evaluation of their biological activities with cultured human cell lines
    Yoshitomo Suhara
    Department of Hygienic Sciences, Kobe Pharmaceutical University, 4 19 1 Motoyamakita machi, Higashinada ku, Kobe 658 8558, Japan
    Bioorg Med Chem 16:3108-17. 2008
    ..The results provide useful information on the structure-activity relationship of vitamin K(2) analogues for the development of new drugs...
  68. ncbi Menaquinone biosynthesis in Escherichia coli: identification of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate as a novel intermediate and re-evaluation of MenD activity
    Ming Jiang
    Department of Chemistry, Center for Cancer Research, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
    Biochemistry 46:10979-89. 2007
    ..coli K12, suggesting that a genuine SHCHC synthase remains to be identified to fully elucidate the ubiquitous biosynthetic pathway...
  69. ncbi Synergistic growth inhibition in HL-60 cells by the combination of acyclic retinoid and vitamin K2
    Junichi Kitagawa
    First Department of Internal Medicine, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu, 501 1194, Japan
    J Cancer Res Clin Oncol 137:779-87. 2011
    ..The aim of this study was to assess the effects of acyclic retinoid (ACR) and vitamin K(2) (VK(2)) in HL-60 cells...
  70. ncbi Menadione is a metabolite of oral vitamin K
    Henk H W Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 95:260-6. 2006
    ..The observations make it likely that part of the menaquinone-4 in tissues results from uptake and prenylation of circulating menadione...
  71. ncbi Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
    ..150 (95% confidence interval: 0.843-1.570, one-sided; P=0.811) between the placebo and combined active-drug groups, and the study was discontinued in March 2007...
  72. ncbi Changes in the redox state and composition of the quinone pool of Escherichia coli during aerobic batch-culture growth
    M Bekker
    Molecular Microbial Physiology Group, Swammerdam Institute for Life Sciences, BioCentrum, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands
    Microbiology 153:1974-80. 2007
    ..Moreover, in exponentially growing cultures in a well-shaken Erlenmeyer flask, it is observed that the assumption of a pseudo-steady state does not hold with respect to the redox state of the quinone pool...
  73. ncbi Synergistic growth inhibition by acyclic retinoid and vitamin K2 in human hepatocellular carcinoma cells
    Toh Kanamori
    Department of Medicine, Gifu University School of Medicine, Gifu, Japan
    Cancer Sci 98:431-7. 2007
    ..This combination might therefore be effective for the chemoprevention and chemotherapy of HCC...
  74. ncbi Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells
    T Ichikawa
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka shi, Saitama 350 1241, Japan
    J Mol Endocrinol 39:239-47. 2007
    ..These results suggest that vitamin K(2) modulates its target gene expression in osteoblastic cells through the PKA-dependent mechanism, which may be distinct from the previously known vitamin K signaling pathways...
  75. ncbi Vitamin K and bone health in adult humans
    Susanne Bugel
    Department of Human Nutrition, University of Copenhagen, Rolighedsvej 30, DK 1958 Frederiksberg C, Denmark
    Vitam Horm 78:393-416. 2008
    ..Furthermore, I will shortly discuss the interaction with vitamin D and the paradox in relation to warfarin treatment...
  76. ncbi Electron transfer ability from NADH to menaquinone and from NADPH to oxygen of type II NADH dehydrogenase of Corynebacterium glutamicum
    Nawarat Nantapong
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Biosci Biotechnol Biochem 69:149-59. 2005
    ..Together with this unique character of NADPH oxidation, phylogenetic analysis of NDH-2 from various organisms suggests that NDH-2 of C. glutamicum is more closely related to yeast or fungal enzymes than to other prokaryotic enzymes...
  77. ncbi Vitamin K2-mediated apoptosis in cancer cells: role of mitochondrial transmembrane potential
    Toshiko Shibayama-Imazu
    Laboratory of Biological Chemistry, School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawaku, Tokyo 142 8555, Japan
    Vitam Horm 78:211-26. 2008
    ..However, other pathways may be involved since cyclosporin A failed to completely inhibit vitamin K2-induced apoptosis...
  78. pmc Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women
    M H J Knapen
    CARIM, University of Maastricht, Maastricht, The Netherlands
    Osteoporos Int 18:963-72. 2007
    ..Results showed that K(2) improved BMC and femoral neck width, but not DXA-BMD. Hence high vitamin K(2) intake may contribute to preventing postmenopausal bone loss...
  79. ncbi Japanese fermented soybean food as the major determinant of the large geographic difference in circulating levels of vitamin K2: possible implications for hip-fracture risk
    M Kaneki
    Department of Geriatric Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Nutrition 17:315-21. 2001
    ....
  80. ncbi Vitamin K supplementation does not affect ovariectomy-induced bone loss in rats
    N Binkley
    Institute on Aging, University of Wisconsin Madison, 53706, USA
    Bone 30:897-900. 2002
    ..Finally, femoral biomechanical properties were not affected by phylloquinone or MK4. To conclude, in this study, neither high-dose phylloquinone nor MK4 reduced the ovx-associated increase in bone turnover or decline in DFBMD...
  81. ncbi Steroid and xenobiotic receptor SXR mediates vitamin K2-activated transcription of extracellular matrix-related genes and collagen accumulation in osteoblastic cells
    Tomoe Ichikawa
    Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School, Saitama 350 1241, Japan
    J Biol Chem 281:16927-34. 2006
    ..Our results suggest a new function for vitamin K2 in bone formation as a transcriptional regulator of extracellular matrix-related genes, that are involved in the collagen assembly...
  82. ncbi Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:307-15. 2006
    ..Moreover, even though the dosing frequency of the drugs was reduced after OVX, treatment continuation appeared to be more beneficial than pretreatment for increasing the cancellous bone mass...
  83. ncbi Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats
    Masatoshi Kobayashi
    Department of Applied Drug Research, Eisai Co, Ltd, Tokyo, Japan
    Jpn J Pharmacol 88:55-61. 2002
    ..These findings suggest that the poor Ca balance observed in ovariectomized rats may be improved by vitamin K2; vitamin K2 may be involved in preventing bone loss in vivo...
  84. ncbi Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats
    K Hara
    Pharmacological Evaluation Section, Department of Applied Drug Research, Eisai Co, Ltd, Tokyo, Japan
    Bone 31:575-81. 2002
    ..K(2) treatment also inhibited the decrease in MS/BS and BFR/BS induced by 30 mg/kg pred. These results suggest that K(2) prevents bone loss partly through the enhancement of bone formation...
  85. ncbi Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:776-83. 2003
    ..The present study provides evidence indicating that vitamin K2 has the potential to suppress bone resorption or bone turnover and/or stimulate bone formation in vivo in ORX and/or NX rats...
  86. ncbi Structural and functional analysis of Vitamin K2 synthesis protein MenD
    Amit Priyadarshi
    Biomedical Research Center, Korea Institute of Science and Technology, Seoul 136 791, South Korea
    Biochem Biophys Res Commun 388:748-51. 2009
    ....
  87. ncbi Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR
    Michelle M Tabb
    Department of Developmental and Cell Biology, University of California, Irvine, California 92697 2300, USA
    J Biol Chem 278:43919-27. 2003
    ..An important implication of this work is that a subset of SXR activators may function as effective therapeutic agents for the management of osteoporosis...
  88. ncbi Regulation of mineral-to-matrix ratio of lumbar trabecular bone in ovariectomized rats treated with risedronate in combination with or without vitamin K2
    Hajime Otomo
    Department of Orthopaedic Surgery, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    J Bone Miner Metab 22:404-14. 2004
    ..Different effects among different drugs on material properties, including mineral-to-matrix ratio, may reflect differences in the relative rate and magnitude of osteoclastic bone resorption and osteoblastic primary bone mineralization...
  89. ncbi The association between dietary vitamin K intake and serum undercarboxylated osteocalcin is modulated by vitamin K epoxide reductase genotype
    Katharina Nimptsch
    Unit of Nutritional Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg DE 69120, Germany
    Br J Nutr 101:1812-20. 2009
    ..Thus, the results show that the inverse association between dietary vitamin K intake and serum ucOC depends on a functionally relevant allelic variant of the VKORC1 gene...
  90. ncbi Combination use of vitamin K(2) further increases bone volume and ameliorates extremely low turnover bone induced by bisphosphonate therapy in tail-suspension rats
    Yoshiko Iwasaki
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Tokyo, Japan
    J Bone Miner Metab 21:154-60. 2003
    ..These data suggested that concomitant use of vitamin K(2) with bisphosphonate excessively ameliorates too much suppression of bone turnover while more efficiently preventing bone volume loss...
  91. pmc Specificity and reactivity in menaquinone biosynthesis: the structure of Escherichia coli MenD (2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1-carboxylate synthase)
    Alice Dawson
    Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK
    J Mol Biol 384:1353-68. 2008
    ..This, in addition to structural and sequence comparisons with putative MenD orthologues, provides insight into the specificity and reactivity of MenD and allows a two-stage reaction mechanism to be proposed...
  92. pmc Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene
    Mamoru Igarashi
    The Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Mol Cell Biol 27:7947-54. 2007
    ..Thus, the present study suggests that Msx2 is a target gene for PXR activated by vitamin K and suggests that the osteoprotective action of MK4 in the human mediates, at least in part, a genomic pathway of vitamin K signaling...
  93. ncbi A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis
    A Shiraishi
    Product Research Laboratory, Chugai Pharmaceutical Co, Ltd, Tokyo, Japan
    Calcif Tissue Int 71:69-79. 2002
    ..These results have important implications in understanding the characteristic actions of vitamin K and active vitamin D on bone metabolism...
  94. ncbi Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women
    Makoto Hirao
    Department of Orthopaedics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka, 565 0871, Japan
    J Bone Miner Metab 26:260-4. 2008
    ....
  95. ncbi Differential lipoprotein transport pathways of K-vitamins in healthy subjects
    Leon J Schurgers
    Department of Biochemistry and Cardiovascular Research Institute, Maastricht University, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Biochim Biophys Acta 1570:27-32. 2002
    ..Moreover, the very long half-life time of MK-9 in the circulation indicates that it may form a more constant source of vitamin K than are either K1 or MK-4...
  96. ncbi Long-term oral anticoagulation reduces bone mass in patients with previous hemispheric infarction and nonrheumatic atrial fibrillation
    Y Sato
    Department of Neurology, Futase Social Insurance Hospital, Iizuka, Japan
    Stroke 28:2390-4. 1997
    ..We evaluated vitamin K and bone mineral density in nonrheumatic atrial fibrillation patients who had long-term warfarin therapy after an ischemic stroke...
  97. ncbi Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol
    T Inoue
    Department of Pediatrics, Yamaguchi University School of Medicine, Ube, Japan
    Endocr J 48:11-8. 2001
    ..Randomized double-blind controlled trials are needed to confirm our findings...
  98. ncbi Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats
    Yoshiko Iwasaki
    Division of Nephrology, Clinical Research Center, Tokyo Teishin Hospital, Fujimi, Japan
    Jpn J Pharmacol 90:88-93. 2002
    ....
  99. ncbi [Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats]
    Masatoshi Kobayashi
    Department of Applied Drug Research, Eisai Co, Ltd, 4 6 10 Koishikawa, Bunkyo ku, Tokyo 112 8088, Japan
    Nihon Yakurigaku Zasshi 120:195-204. 2002
    ..V.K2 also improved the decrease in maximum load in spite of no influence on the cortical thickness, cortical area and Mg concentration in the femur. These findings suggest that V.K2 may affect the qualitative change in bone...
  100. ncbi Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency
    Y Sato
    Department of Rehabilitation Medicine, Hirosaki University School of Medicine, Hirosaki, Japan
    Bone 31:114-8. 2002
    ....
  101. ncbi Maintenance of trabecular structure and bone volume by vitamin K(2) in mature rats with long-term tail suspension
    Yoshiko Iwasaki
    Division of Nephrology and Endocrinology, University of Tokyo School of Medicine, Japan
    J Bone Miner Metab 20:216-22. 2002
    ....

Research Grants19

  1. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..One approach is to coexpress vitamin K 2,3-epoxide reductase subunit 1 (VKORC1) to increase the efficiency of vitamin K recycling hence the enhancement ..
  2. B. subtilis Pho regulation signal transduction network
    F Marion Hulett; Fiscal Year: 2009
    ..These studies will contribute to the knowledge base of two-component signal transduction systems of gram-positive bacteria as targets for antimicrobial therapy. ..
  3. VITAMIN K, METABOLISM AND FUNCTION
    Reidar Wallin; Fiscal Year: 2001
    ..The experiments should also contribute to the exciting, rapidly expanding area of research on extra-hepatic vitamin K-dependent proteins. ..
  4. Vitamin K, Bone, and Arterial Calcification
    Reidar Wallin; Fiscal Year: 2006
    ..The proposed work will provide basic knowledge of BMP-2 growth factor mediated calcification as it is linked to the function of a fat-soluble vitamin (vitamin K) and biosynthesis of vitamin K-dependent proteins. ..
  5. MECHANISM OF RESPIRATION AND ENERGY TRANSDUCTION
    Bernard Trumpower; Fiscal Year: 2009
    ..abstract_text> ..
  6. Inducible Nitric Oxide Synthase and Insulin Resistance
    Masao Kaneki; Fiscal Year: 2009
    ..This project will provide new information to establish novel strategies to prevent and/or treat insulin resistance and obesity-related diabetes. ..
  7. Dietary & non-dietary components of vitamin K metabolism
    Sarah Booth; Fiscal Year: 2008
    ..The findings of the proposed study are critical for the interpretation of the epidemiologic and clinical data used to determine optimal intakes at which vitamin K may have a protective role in bone health. ..
  8. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  9. Vitamin K and Sulfatides in Brain Aging
    Natalia Crivello; Fiscal Year: 2006
    ..These studies will provide the foundation for future studies on the role of dietary vitamin K in sphingolipid metabolism as it relates to healthy aging, and ultimately its role in motor and cognitive behavior. [unreadable] [unreadable]..
  10. Oxidative Stress and Vitamin E Requirements
    Maret Traber; Fiscal Year: 2005
    ..These proposed studies will further our goal of understanding the role of vitamin E in the amelioration of oxidative damage in aging and in chronic diseases, such as heart disease, diabetes and cancer. ..
  11. VITAMIN K AND BONE TURNOVER IN POSTMENOPAUSAL WOMEN
    Neil Binkley; Fiscal Year: 2003
    ..abstract_text> ..
  12. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  13. VITAMIN K INSUFFICIENCY--A RISK FACTOR FOR OSTEOPOROSIS
    Sarah Booth; Fiscal Year: 2001
    ..Results of the studies proposed could lead to effective intervention programs that reduce bone loss resulting in a decreased risk and incidence of osteoporosis. ..
  14. Mechanisms of Vitamin E Function Studied in Zebrafish
    Maret G Traber; Fiscal Year: 2010
    ..the molecular targets altered by - tocopherol-deficiency in the zebrafish will provide a solid basis for understanding why humans require -tocopherol for reproduction as well as to maintain a healthy nervous system ..
  15. Effect of Vitamin K on Age-Related Bone Loss
    Sarah Booth; Fiscal Year: 2005
    ..The proposed trial provides a unique opportunity to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women, above that achieved by supplemental calcium and vitamin D alone. ..
  16. Vitamin K: vascular calcification and age-related bone *
    Sarah Booth; Fiscal Year: 2004
    ..The proposed ancillary trial provides a unique opportunity to determine if vitamin K supplementation will reduce progression of vascular calcification in older men and women...
  17. Alpha-Tocopherol Modulation of Xenobiotic Metabolism
    Maret Traber; Fiscal Year: 2009
    ..We believe that our findings may well have a significant impact on current self-medication practices of the millions of Americans currently taking prescription drugs and vitamin E supplements. ..
  18. Antioxidant Supplementation,Oxidative Stress & Enduranc*
    Maret Traber; Fiscal Year: 2002
    ..Finally, the investigators plan to measure markers of inflammatory response, such as C-oxidants increase and vitamin E decreases these markers. ..