vitamin k

Summary

Summary: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (VITAMIN K 1) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.

Top Publications

  1. ncbi Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation
    Daniela Poli
    Thrombosis Centre Department of Heart and Vessels, AOU Careggi, Florence, Italy
    Circulation 124:824-9. 2011
  2. pmc Vitamin K-dependent carboxylation of osteocalcin: friend or foe?
    Caren M Gundberg
    Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA
    Adv Nutr 3:149-57. 2012
  3. pmc Vitamin K supplementation and progression of coronary artery calcium in older men and women
    M Kyla Shea
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1799-807. 2009
  4. pmc The role of vitamin K in soft-tissue calcification
    Elke Theuwissen
    VitaK, Maastricht University, The Netherlands
    Adv Nutr 3:166-73. 2012
  5. pmc Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum
    Christopher Brampton
    University of Hawai i, Honolulu, Hawai i, USA
    Cell Cycle 10:1810-20. 2011
  6. ncbi Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
  7. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
  8. ncbi Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
  9. ncbi The anticancer effects of vitamin K
    Davis W Lamson
    Coordinator of Oncology, Bastyr University, Kenmore, Washington, USA
    Altern Med Rev 8:303-18. 2003
  10. pmc Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates
    Carla S B Viegas
    Centre of Marine Sciences CCMAR, University of Algarve, 8005 139 Faro, Portugal
    J Biol Chem 283:36655-64. 2008

Detail Information

Publications323 found, 100 shown here

  1. ncbi Bleeding risk in very old patients on vitamin K antagonist treatment: results of a prospective collaborative study on elderly patients followed by Italian Centres for Anticoagulation
    Daniela Poli
    Thrombosis Centre Department of Heart and Vessels, AOU Careggi, Florence, Italy
    Circulation 124:824-9. 2011
    b>Vitamin K antagonist (VKA) therapy is increasingly being used for the prevention of venous thromboembolism and stroke in atrial fibrillation...
  2. pmc Vitamin K-dependent carboxylation of osteocalcin: friend or foe?
    Caren M Gundberg
    Orthopaedics and Rehabilitation, Yale School of Medicine, New Haven, CT, USA
    Adv Nutr 3:149-57. 2012
    ..The presence of 3 vitamin K-dependent γ carboxyglutamic acid residues is critical for osteocalcin's structure, which appears to regulate ..
  3. pmc Vitamin K supplementation and progression of coronary artery calcium in older men and women
    M Kyla Shea
    US Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 89:1799-807. 2009
    Coronary artery calcification (CAC) is an independent predictor of cardiovascular disease. A preventive role for vitamin K in CAC progression has been proposed on the basis of the properties of matrix Gla protein (MGP) as a vitamin K-..
  4. pmc The role of vitamin K in soft-tissue calcification
    Elke Theuwissen
    VitaK, Maastricht University, The Netherlands
    Adv Nutr 3:166-73. 2012
    Seventeen vitamin K-dependent proteins have been identified to date of which several are involved in regulating soft-tissue calcification...
  5. pmc Vitamin K does not prevent soft tissue mineralization in a mouse model of pseudoxanthoma elasticum
    Christopher Brampton
    University of Hawai i, Honolulu, Hawai i, USA
    Cell Cycle 10:1810-20. 2011
    ..The inability of this transporter to secrete its substrate into the circulation is the likely cause of PXE. Vitamin K plays a role in the regulation of mineralization processes as a co-factor in the carboxylation of calcification ..
  6. ncbi Post-translational modifications regulate matrix Gla protein function: importance for inhibition of vascular smooth muscle cell calcification
    L J Schurgers
    Cardiovascular Research Institute Maastricht and VitaK, University of Maastricht, Universiteitssingel 50, Maastricht, The Netherlands
    J Thromb Haemost 5:2503-11. 2007
    Matrix Gla protein (MGP) is a small vitamin K-dependent protein containing five gamma-carboxyglutamic acid (Gla) residues that are believed to be important in binding Ca(2+), calcium crystals and bone morphogenetic protein...
  7. ncbi Gas6 and protein S. Vitamin K-dependent ligands for the Axl receptor tyrosine kinase subfamily
    Sassan Hafizi
    Lund University, Department of Laboratory Medicine, Section for Clinical Chemistry, Wallenberg Laboratory, University Hospital Malmo, Sweden
    FEBS J 273:5231-44. 2006
    Gas6 and protein S are two homologous secreted proteins that depend on vitamin K for their execution of a range of biological functions...
  8. ncbi Warfarin causes rapid calcification of the elastic lamellae in rat arteries and heart valves
    P A Price
    Department of Biology, University of California, San Diego, La Jolla 92093 0368, USA
    Arterioscler Thromb Vasc Biol 18:1400-7. 1998
    ..overall weight gain, or serum calcium and phosphorus levels, and, because of the concurrent administration of vitamin K, prothrombin times and hematocrits were normal...
  9. ncbi The anticancer effects of vitamin K
    Davis W Lamson
    Coordinator of Oncology, Bastyr University, Kenmore, Washington, USA
    Altern Med Rev 8:303-18. 2003
    b>Vitamin K, an essential nutrient often associated with the clotting cascade, has been the focus of considerable research demonstrating an anticancer potential...
  10. pmc Gla-rich protein (GRP), a new vitamin K-dependent protein identified from sturgeon cartilage and highly conserved in vertebrates
    Carla S B Viegas
    Centre of Marine Sciences CCMAR, University of Algarve, 8005 139 Faro, Portugal
    J Biol Chem 283:36655-64. 2008
    We report the isolation of a novel vitamin K-dependent protein from the calcified cartilage of Adriatic sturgeon (Acipenser nacarii). This 10...
  11. ncbi Vitamin K-dependent carboxylation of matrix Gla-protein: a crucial switch to control ectopic mineralization
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Universiteitssingel 50, 6200 MD Maastricht, The Netherlands
    Trends Mol Med 19:217-26. 2013
    ..The discovery that the vitamin K-dependent matrix Gla-protein (MGP) is a strong inhibitor of vascular calcification has propelled our mechanistic ..
  12. ncbi Hemorrhagic complications of anticoagulant and thrombolytic treatment: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Sam Schulman
    McMaster Clinics, HHS General Hospital, 237 Barton Street E, Hamilton, Ontario, Canada
    Chest 133:257S-298S. 2008
    ..The major determinants of vitamin K antagonist (VKA)-induced bleeding are the intensity of the anticoagulant effect, underlying patient ..
  13. ncbi Vitamin K, vertebral fractures, vascular calcifications, and mortality: VItamin K Italian (VIKI) dialysis study
    Maria Fusaro
    Aging Section, Consiglio Nazionale delle Ricerche CNR Institute of Neuroscience, Padua, Italy
    J Bone Miner Res 27:2271-8. 2012
    b>Vitamin K (vitamin K1 or phylloquinone and vitamin K2, a series of menaquinones [MKs]) is involved in the production of bone and matrix amino acid γ-carboxy-glutamic acid (Gla) proteins, regulating bone and vascular calcification...
  14. ncbi Bleeding during treatment with aspirin versus apixaban in patients with atrial fibrillation unsuitable for warfarin: the apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K
    Greg C Flaker
    University of Missouri Columbia, Five Hospital Drive, CE306, Columbia, MO 65212, USA
    Stroke 43:3291-7. 2012
    ..comparable bleeding risks when compared with aspirin in patients with atrial fibrillation who are unsuitable for vitamin k antagonist therapy...
  15. ncbi Increased production of functional recombinant human clotting factor IX by baby hamster kidney cells engineered to overexpress VKORC1, the vitamin K 2,3-epoxide-reducing enzyme of the vitamin K cycle
    Nadeem Wajih
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 280:31603-7. 2005
    Some recombinant vitamin K-dependent blood coagulation factors (factors VII, IX, and protein C) have become valuable pharmaceuticals in the treatment of bleeding complications and sepsis...
  16. ncbi Bleeding with anticoagulation therapy - who is at risk, and how best to identify such patients
    Gualtiero Palareti
    Department of Angiology and Blood Coagulation Marino Golinelli, University Hospital S Orsola Malpighi, Via Albertoni, 15, 40138 Bologna, Italy
    Thromb Haemost 102:268-78. 2009
    Anticoagulation with vitamin K antagonists (VKAs) has been shown to be effective in the prevention and treatment of thrombotic complications in various clinical settings, including atrial fibrillation (AF), venous thromboembolism (VTE), ..
  17. ncbi Metabolism and cell biology of vitamin K
    Martin J Shearer
    Centre for Haemostasis and Thrombosis, St Thomas Hospital, Westminster Bridge Road, London, UK
    Thromb Haemost 100:530-47. 2008
    Naturally occurring vitamin K compounds comprise a plant form, phylloquinone (vitamin K(1)) and a series of bacterial menaquinones (MKs) (vitamin K(2))...
  18. ncbi Patients using vitamin K antagonists show increased levels of coronary calcification: an observational study in low-risk atrial fibrillation patients
    Bob Weijs
    Department of Cardiology, Maastricht University Medical Centre and Cardiovascular Research Institute Maastricht CARIM, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Heart J 32:2555-62. 2011
    b>Vitamin K antagonists (VKA) are currently the most frequently used drug to prevent ischaemic stroke in atrial fibrillation (AF) patients. However, VKA use has been associated with increased vascular calcification...
  19. ncbi The inhibitory effect of calumenin on the vitamin K-dependent gamma-carboxylation system. Characterization of the system in normal and warfarin-resistant rats
    Nadeem Wajih
    Departments of Internal Medicine and Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 279:25276-83. 2004
    The vitamin K-dependent gamma-carboxylation system is responsible for post-translational modification of vitamin K-dependent proteins, converting them to Gla-containing proteins...
  20. pmc A food frequency questionnaire for the assessment of calcium, vitamin D and vitamin K: a pilot validation study
    Janet M Pritchard
    McMaster University, W Hamilton ON L8N 3Z5, Canada
    Nutrients 2:805-19. 2010
    The study objective was to validate a food frequency questionnaire (FFQ) to assess calcium, vitamin D and vitamin K intakes in overweight and obese postmenopausal community-dwelling women...
  21. ncbi Roles for vitamin K beyond coagulation
    Sarah L Booth
    Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center at Tufts University, Boston, MA 02111, USA
    Annu Rev Nutr 29:89-110. 2009
    Recent interest in vitamin K has been motivated by evidence of physiological roles beyond that of coagulation...
  22. ncbi Management issues for women with epilepsy--focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of
    Cynthia L Harden
    University of Miami, Miami, Florida, USA
    Epilepsia 50:1247-55. 2009
    ..to the care of women with epilepsy (WWE) during pregnancy, including preconceptional folic acid and prenatal vitamin K use and the clinical implications of placental and breast-milk transfer of antiepileptic drugs (AEDs)...
  23. ncbi Individual time within target range in patients treated with vitamin K antagonists: main determinant of quality of anticoagulation and predictor of clinical outcome. A retrospective study of 2300 consecutive patients with venous thromboembolism
    Nic J G M Veeger
    Division of Haemostasis, Thrombosis and Rheology, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    Br J Haematol 128:513-9. 2005
    The efficacy and safety of vitamin K antagonists (VKA) are related to the actual level of anticoagulation (given as the international normalized ratio, INR). It is often difficult to maintain an optimal INR over time...
  24. ncbi Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?
    Joyce C McCann
    Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 90:889-907. 2009
    ..For 16 known vitamin K-dependent (VKD) proteins, we evaluated the relative lethality of 11 known mouse knockout mutants to categorize ..
  25. ncbi Dabigatran and warfarin in vitamin K antagonist-naive and -experienced cohorts with atrial fibrillation
    Michael D Ezekowitz
    Lankenau Institute for Medical Research, 100 Lancaster Ave, Suite G36, Wynnewood, PA 19096, USA
    Circulation 122:2246-53. 2010
    The comparison of anticoagulants dabigatran and warfarin might be most equitable in vitamin K antagonist (VKA)-naive patients.
  26. ncbi Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells
    Daniel L Coutu
    Division of Experimental Medicine, McGill University, Montreal, Quebec, Canada
    J Biol Chem 283:17991-8001. 2008
    ..glutamic acid residues to gamma-carboxyglutamic acid (Gla) is a post-translational modification catalyzed by the vitamin K-dependent enzyme gamma-glutamylcarboxylase...
  27. ncbi Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin
    C M Gundberg
    Department of Orthopaedics and Rehabilitation, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Endocrinol Metab 83:3258-66. 1998
    ..Without these precautions, the assessment of undercarboxylated osteocalcin is not reliable...
  28. ncbi Pseudoxanthoma elasticum-like phenotype with cutis laxa and multiple coagulation factor deficiency represents a separate genetic entity
    Olivier M Vanakker
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    J Invest Dermatol 127:581-7. 2007
    ..PXE)-like phenotype, characterized by excessive skin folding (resembling cutis laxa) and a deficiency of the vitamin K-dependent clotting factors (II, VII, IX, and X) are presented...
  29. ncbi Idraparinux versus standard therapy for venous thromboembolic disease
    Harry R Buller
    Academic Medical Center, Department of Vascular Medicine, F4 211, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    N Engl J Med 357:1094-104. 2007
    Venous thromboembolism is treated with unfractionated heparin or low-molecular-weight heparin, followed by a vitamin K antagonist...
  30. ncbi Influence of dietary vitamin K intake on subtherapeutic oral anticoagulant therapy
    Eva K Rombouts
    Department of Thrombosis and Haemostasis, Leiden University Medical Centre, Leiden, The Netherlands
    Br J Haematol 149:598-605. 2010
    It is unclear what advice should be given to patients using vitamin K antagonists with respect to dietary vitamin K intake...
  31. pmc Suboptimal vitamin K status despite supplementation in children and young adults with cystic fibrosis
    Kelly A Dougherty
    Department of Pediatrics, Children s Hospital of Philadelphia, PA 19104, USA
    Am J Clin Nutr 92:660-7. 2010
    For children and adolescents with cystic fibrosis (CF) and pancreatic insufficiency, the efficacy of routine vitamin K supplementation to normalize vitamin K status remains unclear.
  32. pmc Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients
    Paul Y Boxma
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e47991. 2012
    b>Vitamin K is essential for activation of γ-carboxyglutamate (Gla)-proteins including the vascular calcification inhibitor matrix Gla-protein (MGP)...
  33. ncbi Polymorphisms in vitamin K-dependent gamma-carboxylation-related genes influence interindividual variability in plasma protein C and protein S activities in the general population
    Rina Kimura
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Int J Hematol 84:387-97. 2006
    gamma-Glutamyl carboxylation, a reaction essential for the activity of vitamin K-dependent proteins, requires the concerted actions of gamma-glutamyl carboxylase (GGCX), vitamin K 2, 3-epoxide reductase complex 1 (VKORC1), and the ..
  34. ncbi Expression of the vitamin K-dependent proteins GAS6 and protein S and the TAM receptor tyrosine kinases in human atherosclerotic carotid plaques
    B Hurtado
    Translational Research Laboratory, Catalan Institute of Oncology IDIBELL, L Hospitalet de Llobregat, Spain
    Thromb Haemost 105:873-82. 2011
    The GAS6/ProS-TAM system is composed of two vitamin K-dependent ligands (GAS6 and protein S) and their three protein tyrosine kinase receptors TYRO3, AXL and MERTK, known as the TAM receptors...
  35. ncbi Bleeding after initiation of multiple antithrombotic drugs, including triple therapy, in atrial fibrillation patients following myocardial infarction and coronary intervention: a nationwide cohort study
    Morten Lamberts
    Department of Cardiology, Post 635, Copenhagen University Hospital Gentofte, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Circulation 126:1185-93. 2012
    ..We investigated the risk and time frame for bleeding following myocardial infarction/percutaneous coronary intervention in patients with atrial fibrillation according to antithrombotic treatment...
  36. ncbi [Quantification of the part allocated to the preventability of vitamin K antagonists therapy bleeding events]
    Valérie Gras-Champel
    Service de Pharmacologie Clinique, Centre Regional de Pharmacovigilance, CHU Amiens Sud, Inserm ERI12 EA4292, Amiens, France
    Therapie 65:261-8. 2010
    A prospective cohort of patients with a high INR (>or=5) and being treated by vitamin K antagonists (VKA) was assessed in the Amiens University Hospital...
  37. ncbi Vitamin K, osteoporosis and degenerative diseases of ageing
    Cees Vermeer
    VitaK, Maastricht University, Oxfordlaan 70, 6229 EV Maastricht, The Netherlands
    Menopause Int 17:19-23. 2011
    The function of vitamin K is to serve as a co-factor during the post-translational carboxylation of glutamate (Glu) residues into γ-carboxyglutamate (Gla) residues...
  38. pmc An endogenous vitamin K-dependent mechanism regulates cell proliferation in the brain subventricular stem cell niche
    Aurore Gely-Pernot
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187 Université de Poitiers, Poitiers, France
    Stem Cells 30:719-31. 2012
    ..The endogenous mechanisms underpinning SVZ stem and progenitor cell proliferation are not fully elucidated. Vitamin K-dependent proteins (VKDPs) are mainly secreted factors that were initially discovered as major regulators of ..
  39. ncbi Clinical experience with oral versus intravenous vitamin K for warfarin reversal
    Robert Meehan
    From the Blood Bank and Department of Medicine, Roger Williams Hospital, Providence, Rhode Island
    Transfusion 53:491-8; quiz 490. 2013
    Reversal of warfarin with plasma accounts for a large amount of fresh-frozen plasma transfused in the United States. The use of vitamin K is an alternate strategy.
  40. pmc Circulating uncarboxylated matrix gla protein is associated with vitamin K nutritional status, but not coronary artery calcium, in older adults
    M Kyla Shea
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 141:1529-34. 2011
    Matrix Gla protein (MGP) is a calcification inhibitor in vascular tissue that must be carboxylated by vitamin K to function...
  41. ncbi Low-dose menaquinone-7 supplementation improved extra-hepatic vitamin K status, but had no effect on thrombin generation in healthy subjects
    Elke Theuwissen
    VitaK and Cardiovascular Research Institute Maastricht, Maastricht University, Oxfordlaan 70, Maastricht, The Netherlands
    Br J Nutr 108:1652-7. 2012
    b>Vitamin K is required for the carboxylation of Gla-proteins in the liver (coagulation factors) and extra-hepatic tissues, such as bone (osteocalcin, OC), and arterial wall (matrix Gla-protein, MGP)...
  42. ncbi Enhancement of skin penetration of vitamin K using monoolein-based liquid crystalline systems
    Luciana B Lopes
    Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Av do Cafe, S N, 14040 930, Ribeirao Preto, SP, Brazil
    Eur J Pharm Sci 32:209-15. 2007
    Application of vitamin K (vitK) to the skin has been used for suppression of pigmentation and resolution of bruising. However, there is no report concerning the extent of its penetration in the skin...
  43. ncbi Vitamin K status in peritoneally dialyzed patients with chronic kidney disease
    Hanna Stankowiak-Kulpa
    Department of Internal Medicine, Metabolism and Dietetics, Poznan University of Medical Sciences, Poznan, Poland
    Acta Biochim Pol 58:617-20. 2011
    Abnormal vitamin K status was documented in patients with chronic kidney diseases (CKD), especially those undergoing hemodialysis. The data related to patients undergoing peritoneal dialysis (PD) are contradictory...
  44. ncbi Prevalence of vitamin K deficiency in children with mild to moderate chronic liver disease
    Diana R Mager
    Department of Clinical Dietetics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada
    J Pediatr Gastroenterol Nutr 42:71-6. 2006
    Children with chronic liver disease are at risk for vitamin K deficiency because of fat malabsorption and inadequate dietary intake...
  45. ncbi Current pharmacogenetic developments in oral anticoagulation therapy: the influence of variant VKORC1 and CYP2C9 alleles
    Johannes Oldenburg
    Institute for Experimental Haematology and Transfusion Medicine, University Clinic Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Thromb Haemost 98:570-8. 2007
    ..Furthermore, concomitant application of low dose vitamin K may significantly reduce intra-individual coumarin dose variation and, thus, may stabilize oral anticoagulation ..
  46. ncbi Safety of prothrombin complex concentrates for rapid anticoagulation reversal of vitamin K antagonists. A meta-analysis
    Francesco Dentali
    University of Insubria, Varese, Italy
    Thromb Haemost 106:429-38. 2011
    ..We performed a meta-analysis to estimate the rate of thromboembolic complications in patients receiving vitamin K antagonists (VKAs) treated with PCCs for bleeding or before urgent surgery...
  47. ncbi Circulating matrix Gla protein is associated with coronary artery calcification and vitamin K status in healthy women
    Geertje W Dalmeijer
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Nutr Biochem 24:624-8. 2013
    Matrix Gla protein (MGP) is a vitamin K-dependent protein and an inhibitor of vascular calcification. Vitamin K is required for the carboxylation of MGP and can thereby reduce calcification...
  48. ncbi Regression of warfarin-induced medial elastocalcinosis by high intake of vitamin K in rats
    Leon J Schurgers
    Cardiovascular Research Institute CARIM, Maastricht University, The Netherlands
    Blood 109:2823-31. 2007
    ..Matrix Gla protein (MGP) is a potent inhibitor of AC, and its activity depends on vitamin K (VK)...
  49. ncbi The vitamin K cycle
    D W Stafford
    Department of Biology and Pathology, University of North Carolina, Chapel Hill, NC 27599 3280, USA
    J Thromb Haemost 3:1873-8. 2005
    Post-translational modification of glutamate to gamma carboxyl glutamate is required for the activity of vitamin K-dependent proteins...
  50. ncbi Bleeding rates in patients older than 90 years of age on vitamin K antagonist therapy for nonvalvular atrial fibrillation
    Enrico Tincani
    Unità Operativa di Post Acuzie e Lungodegenza, Nuovo Ospedale Civile di Modena S Agostino Estense, Modena, Italy
    Blood Coagul Fibrinolysis 20:47-51. 2009
    ..Six (7%) patients discontinued vitamin K antagonists (three due to bleeding, two due to noncompliance, two due to physician recommendation)...
  51. ncbi Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status
    Sarah L Booth
    Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Am J Clin Nutr 80:143-8. 2004
    ..Although a vitamin E-vitamin K interaction was proposed to underlie this effect, it has not been systematically investigated in adults with ..
  52. ncbi Effect of oral antiplatelet agents on major bleeding in users of coumarins
    Tom Schalekamp
    Division of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    Thromb Haemost 100:1076-83. 2008
    Treatment with vitamin K antagonists (coumarins) is associated with an increased risk of bleeding...
  53. pmc Vitamin K-antagonists accelerate atherosclerotic calcification and induce a vulnerable plaque phenotype
    Leon J Schurgers
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre, Maastricht, The Netherlands
    PLoS ONE 7:e43229. 2012
    b>Vitamin K-antagonists (VKA) are treatment of choice and standard care for patients with venous thrombosis and thromboembolic risk. In experimental animal models as well as humans, VKA have been shown to promote medial elastocalcinosis...
  54. ncbi Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health
    Cees Vermeer
    Dept of Biochemistry, University of Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    Eur J Nutr 43:325-35. 2004
    b>Vitamin K is well known for its role in the synthesis of a number of blood coagulation factors. During recent years vitamin K-dependent proteins were discovered to be of vital importance for bone and vascular health...
  55. ncbi Vitamin K and bone health
    P Weber
    Vitamins and Fine Chemicals Division, Human Nutrition and Health, F Hoffmann La Roche Ltd, CH 4070 Basel, Switzerland
    Nutrition 17:880-7. 2001
    In the past decade it has become evident that vitamin K has a significant role to play in human health that is beyond its well-established function in blood clotting...
  56. ncbi Warfarin and the vitamin K-dependent gamma-carboxylation system
    Reidar Wallin
    Departments of Internal Medicine and Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Trends Mol Med 10:299-302. 2004
    ..This finding strongly suggests that the protein is part of the vitamin K cycle, which is essential for the production of vitamin K-dependent proteins...
  57. ncbi Vascular calcification: the price to pay for anticoagulation therapy with vitamin K-antagonists
    Martijn L L Chatrou
    Department of Biochemistry, Cardiovascular Research Institute Maastricht, MUMC, Maastricht, The Netherlands
    Blood Rev 26:155-66. 2012
    b>Vitamin K-antagonists (VKA) are the most widely used anti-thrombotic drugs with substantial efficacy in reducing risk of arterial and venous thrombosis...
  58. ncbi Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials
    Yanfu Fang
    School of Public Health, Anhui Medical University, 81 Mei Shan Road, Hefei 230032, Anhui, China
    J Bone Miner Metab 30:60-8. 2012
    A number of randomized controlled trials (RCTs) examining the role of vitamin K on bone mineral density (BMD) have yielded inconsistent results. We performed a meta-analysis of these trials to assess the effect of vitamin K on BMD...
  59. ncbi Rationale and design of AVERROES: apixaban versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who have failed or are unsuitable for vitamin K antagonist treatment
    John W Eikelboom
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada L8L 2X2
    Am Heart J 159:348-353.e1. 2010
    Many patients with atrial fibrillation (AF) at moderate or high risk for stroke are not treated with a vitamin K antagonist (VKA)...
  60. ncbi Homologous metabolic and gene activating routes for vitamins E and K
    Nico Landes
    Department of Vitamins and Atherosclerosis, German Institute of Human Nutrition, University of Potsdam, Arthur Scheunert Allee 114 116, Bergholz Rehbruecke D 14558, Germany
    Mol Aspects Med 24:337-44. 2003
    ..For vitamin K the same mechanism can be suggested analogously...
  61. ncbi Apoptosis-inducing activity of vitamin C and vitamin K
    H Sakagami
    Department of Dental Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Cell Mol Biol (Noisy-le-grand) 46:129-43. 2000
    ..Synergistic apoptosis-inducing actions have been found between vitamins C and K, and between these vitamins and antiproliferative agents. The possible therapeutic application of these vitamins is discussed...
  62. ncbi Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the Dutch and Danish biliary atresia registries
    Peter M van Hasselt
    Department of Pediatrics, Wilhelmina Children s Hospital, University Medical Center Utrecht, Lundlaan 6, 3584EA, Utrecht, The Netherlands
    Pediatrics 121:e857-63. 2008
    Newborns routinely receive vitamin K to prevent vitamin K deficiency bleeding. The efficacy of oral vitamin K administration may be compromised in infants with unrecognized cholestasis...
  63. ncbi Vitamin K, an update for the paediatrician
    Myriam Van Winckel
    Department of Paediatrics, UZ Gent, De Pintelaan 185, 9000 Ghent, Belgium
    Eur J Pediatr 168:127-34. 2009
    This review summarizes current knowledge on vitamin K for the paediatrician. Vitamin K is a fat-soluble vitamin, present in plants as phylloquinone and produced by bacteria as menaquinone...
  64. doi Comparison of idraparinux with vitamin K antagonists for prevention of thromboembolism in patients with atrial fibrillation: a randomised, open-label, non-inferiority trial
    M G Bousser
    Lancet 371:315-21. 2008
    b>Vitamin K antagonists, the current standard treatment for prophylaxis against stroke and systemic embolism in patients with atrial fibrillation, require regular monitoring and dose adjustment; an unmonitored, fixed-dose anticoagulant ..
  65. ncbi Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms
    Gerald J Atkins
    Univ of Adelaide, Hanson Institute, SA, Australia
    Am J Physiol Cell Physiol 297:C1358-67. 2009
    The vitamin K family members phylloquinone (vitamin K1) and the menaquinones (vitamin K2) are under study for their roles in bone metabolism and as potential therapeutic agents for skeletal diseases...
  66. ncbi Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins
    Mingdong Huang
    Center for Hemostasis and Thrombosis Research, Beth Israel Deaconess Medical Center and Department of Medicine, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nat Struct Biol 10:751-6. 2003
    In a calcium-dependent interaction critical for blood coagulation, vitamin K-dependent blood coagulation proteins bind cell membranes containing phosphatidylserine via gamma-carboxyglutamic acid-rich (Gla) domains...
  67. ncbi The first evaluation of a novel vitamin K antagonist, tecarfarin (ATI-5923), in patients with atrial fibrillation
    David J Ellis
    ARYx Therapeutics Inc, Fremont, Calif, USA
    Circulation 120:1029-35, 2 p following 1035. 2009
    Tecarfarin (ATI-5923) is a novel oral vitamin K antagonist...
  68. ncbi Vitamin K-dependent carboxylation
    Kathleen L Berkner
    Department of Molecular Cardiology, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Vitam Horm 78:131-56. 2008
    b>Vitamin K-dependent (VKD) protein carboxylation uses vitamin K epoxidation to convert Glus to carboxylated Glus (Glas), rendering VKD proteins active in physiologies that include hemostasis, apoptosis, bone mineralization, calcium ..
  69. ncbi Outpatient management of oral vitamin K antagonist therapy: defining and measuring high-quality management
    Katherine W Phillips
    Boston University School of Medicine, Department of Medicine, Boston, MA 02118, USA
    Expert Rev Cardiovasc Ther 6:57-70. 2008
    ..Healthcare providers who manage oral anticoagulation therapy should utilize these parameters as a measure of their performance in an effort to achieve high-quality anticoagulation management...
  70. ncbi Cancer prevention and vitamin K antagonists: an overview
    Vittorio Pengo
    Department of Cardiac Thoracic and Vascular Sciences, Division of Clinical Cardiology, Clinical Medicine, University of Padova, Padova, Italy
    Thromb Res 125:S103-5. 2010
    ....
  71. ncbi Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg)
    Katharina Nimptsch
    Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Am J Clin Nutr 91:1348-58. 2010
    Anticarcinogenic activities of vitamin K have been observed in animal and cell studies.
  72. pmc Oral direct thrombin inhibitor AZD0837 for the prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation: a randomized dose-guiding, safety, and tolerability study of four doses of AZD0837 vs. vitamin K antagonists
    Gregory Y H Lip
    University of Birmingham Centre for Cardiovascular Sciences, City Hospital, Dudley Road, Birmingham B18 7QH, UK
    Eur Heart J 30:2897-907. 2009
    Oral anticoagulation with vitamin K antagonists (VKAs) for stroke prevention in atrial fibrillation (AF) is effective but has significant limitations...
  73. ncbi Oxygen free radical generating mechanisms in the colon: do the semiquinones of vitamin K play a role in the aetiology of colon cancer?
    M Valko
    Department of Physical Chemistry, Slovak Technical University, Bratislava
    Biochim Biophys Acta 1527:161-6. 2001
    ..A model is presented in which the reduced K vitamins may initiate superoxide radical, O2(-*) generation leading to Fe(II) mediated Fenton reactions in the stem colon cells...
  74. ncbi Warfarin pharmacology, clinical management, and evaluation of hemorrhagic risk for the elderly
    Laurie G Jacobs
    Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210 Street, Bronx, NY 10467, USA
    Cardiol Clin 26:157-67, v. 2008
    Warfarin, a vitamin K antagonist, is currently the most extensively used oral anticoagulant world-wide. It is prescribed for a variety of indications and has undergone extensive clinical study...
  75. ncbi Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome
    Olivier M Vanakker
    Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
    Lab Invest 90:895-905. 2010
    ..This post-translational modification is catalyzed by the gammaglutamyl carboxylase GGCX and requires vitamin K (VK) as an essential co-factor...
  76. pmc Vitamin K, circulating cytokines, and bone mineral density in older men and women
    M Kyla Shea
    US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA
    Am J Clin Nutr 88:356-63. 2008
    b>Vitamin K modulates cytokines involved in bone turnover, including interleukin-6 (IL-6) and osteoprotegerin in vitro.
  77. ncbi Antithrombotic therapy for venous thromboembolic disease: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Clive Kearon
    Hamilton Health Sciences, Henderson Division, 711 Concession Street, Hamilton, Ontario, Canada
    Chest 133:454S-545S. 2008
    ..with LMWH, UFH or fondaparinux for at least 5 days rather than a shorter period (Grade 1C); and initiation of vitamin K antagonists (VKAs) together with LMWH, UFH, or fondaparinux on the first treatment day, and discontinuation of ..
  78. ncbi Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)
    Jack Ansell
    Department of Medicine, Boston University Medical Center, 88 East Newton Street, Boston, MA 02118, USA
    Chest 133:160S-198S. 2008
    This article concerning the pharmacokinetics and pharmacodynamics of vitamin K antagonists (VKAs) is part of the American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition)...
  79. ncbi Does the absence of ABCC6 (multidrug resistance protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery?
    Piet Borst
    The Netherlands Cancer Institute, Division of Molecular Biology, Amsterdam, The Netherlands
    Cell Cycle 7:1575-9. 2008
    ..We propose that this plasma factor is vitamin K (precursor)...
  80. pmc Vitamin K supplementation in postmenopausal women with osteopenia (ECKO trial): a randomized controlled trial
    Angela M Cheung
    Department of Medicine, Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    PLoS Med 5:e196. 2008
    b>Vitamin K has been widely promoted as a supplement for decreasing bone loss in postmenopausal women, but the long-term benefits and potential harms are unknown...
  81. ncbi High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nutr Res 29:221-8. 2009
    Although systematic review and meta-analysis of randomized controlled trials (RCTs) have concluded that vitamin K is effective in preventing fractures, the effect of vitamin K on the skeleton remains a matter of controversy...
  82. ncbi Vitamin K-dependent actions of Gas6
    Lola Bellido-Martin
    Department of Cell Death and Proliferation, Institute for Biomedical Research of Barcelona, IIBB CSIC IDIBAPS, Barcelona 08036, Spain
    Vitam Horm 78:185-209. 2008
    Gas6 (growth arrest-specific gene 6) is the last addition to the family of plasma vitamin K-dependent proteins. Gas6 was cloned and characterized in 1993 and found to be similar to the plasma anticoagulant protein S...
  83. ncbi Risk of bleeding in patients with acute myocardial infarction treated with different combinations of aspirin, clopidogrel, and vitamin K antagonists in Denmark: a retrospective analysis of nationwide registry data
    Rikke Sørensen
    Department of Cardiology, Copenhagen University Hospital Gentofte, Hellerup, Denmark
    Lancet 374:1967-74. 2009
    Combinations of aspirin, clopidogrel, and vitamin K antagonists are widely used in patients after myocardial infarction. However, data for the safety of combinations are sparse...
  84. ncbi The vitamin K cycle
    Johannes Oldenburg
    Institute of Experimental Haematology and Transfusion Medicine, University Clinic Bonn, D 53105 Bonn, Germany
    Vitam Horm 78:35-62. 2008
    b>Vitamin K is a collective term for lipid-like naphthoquinone derivatives synthesized only in eubacteria and plants and functioning as electron carriers in energy transduction pathways and as free radical scavengers maintaining ..
  85. pmc Administration of vitamin K does not counteract the ectopic mineralization of connective tissues in Abcc6 (-/-) mice, a model for pseudoxanthoma elasticum
    Qiujie Jiang
    Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:701-7. 2011
    ..Alterations in vitamin K metabolism have been suggested to contribute to the pathomechanisms of the mineralization process...
  86. ncbi Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial
    Paolo Prandoni
    Department of Medical and Surgical Sciences, University Hospital of Padua, Padua, Italy
    Ann Intern Med 141:249-56. 2004
    ..Because only limited evidence suggests that elastic stockings prevent the post-thrombotic syndrome in patients with symptomatic deep venous thrombosis (DVT), these stockings are not widely used...
  87. ncbi Menadione is a metabolite of oral vitamin K
    Henk H W Thijssen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht, University of Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    Br J Nutr 95:260-6. 2006
    ..In the present study we explored the presence of menadione in urine and the effect of vitamin K intake on its excretion. Menadione in urine was analysed by HPLC assay with fluorescence detection...
  88. ncbi Common genetic variants of microsomal epoxide hydrolase affect warfarin dose requirements beyond the effect of cytochrome P450 2C9
    Ronen Loebstein
    Institute of Clinical Pharmacology and Toxicology, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Clin Pharmacol Ther 77:365-72. 2005
    ..on warfarin dose requirements of candidate genes encoding microsomal epoxide hydrolase (mEH), as well as glutathione S -transferase A1 (GSTA1) components of vitamin K epoxide reductase and the gamma-glutamylcarboxylase (GGCX) gene.
  89. ncbi Vitamin K status is associated with childhood bone mineral content
    Marieke J H van Summeren
    Department of Paediatric Immunology, University Medical Centre Utrecht, PO Box 85090, Utrecht, The Netherlands
    Br J Nutr 100:852-8. 2008
    In adult bone, vitamin K contributes to bone health, probably through its role as co-factor in the carboxylation of osteocalcin. In children, the significance of vitamin K in bone-mass acquisition is less well known...
  90. pmc Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North American women
    Neil Binkley
    University of Wisconsin Osteoporosis Clinical Research Program, Madison, Wisconsin 53705, USA
    J Bone Miner Res 24:983-91. 2009
    Low vitamin K status is associated with low BMD and increased fracture risk. Additionally, a specific menaquinone, menatetrenone (MK4), may reduce fracture risk...
  91. ncbi Vitamin K deficiency reduces testosterone production in the testis through down-regulation of the Cyp11a a cholesterol side chain cleavage enzyme in rats
    Hitoshi Shirakawa
    Laboratory of Nutrition, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Biochim Biophys Acta 1760:1482-8. 2006
    b>Vitamin K (K) is an essential factor for the posttranslational modification of blood coagulation factors as well as proteins in the bone matrix (Gla proteins)...
  92. ncbi Vitamin K-dependent gamma-glutamylcarboxylation: an ancient posttranslational modification
    Pradip K Bandyopadhyay
    Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112, USA
    Vitam Horm 78:157-84. 2008
    The vitamin K-dependent carboxylase carries out the posttranslational modification of specific glutamate residues in proteins to gamma-carboxy glutamic acid (Gla) in the presence of reduced vitamin K, molecular oxygen, and carbon dioxide...
  93. ncbi Immunomodulatory effects in vitro of vitamin K antagonist acenocoumarol
    S Schroecksnadel
    Division of Biological Chemistry, Medical University, Innsbruck, Austria
    Thromb Res 131:e264-9. 2013
    ..To examine the potential impact of vitamin K-antagonist acenocoumarol (Sintrom) on the inflammatory response we investigated its effect on freshly isolated ..
  94. ncbi Low-dose oral vitamin K reliably reverses over-anticoagulation due to warfarin
    M A Crowther
    Hamilton Civic Hospitals Research Centre, Henderson General Hospital, ON, Canada
    Thromb Haemost 79:1116-8. 1998
    ..The most appropriate management strategy in these patients is unknown. This prospective cohort study was designed to address whether 1 mg of oral vitamin K effectively reduces the INR value of such patients.
  95. pmc Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes
    Jianrong Li
    The F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Neurosci Res 87:1997-2005. 2009
    ..We previously demonstrated a novel function of phylloquinone (vitamin K(1)) and menaquinone 4 (MK-4; a major form of vitamin K2) in protecting pre-OLs and immature neurons against ..
  96. ncbi Treatment of warfarin-associated coagulopathy with vitamin K
    Christopher Patriquin
    Division of Hematology and Thromboembolism, Department of Medicine, McMaster University, Hamilton, ON, Canada
    Expert Rev Hematol 4:657-65; quiz 666-7. 2011
    ..As warfarin exerts its effect by impairing formation of the vitamin K-dependent clotting factors, a cornerstone of WAC management is vitamin K replacement...
  97. ncbi Long-term use of vitamin K antagonists and incidence of cancer: a population-based study
    Vittorio Pengo
    Department of Cardiothoracic and Vascular Sciences, Division of Clinical Cardiology, Universita di Padova, School of Medicine, Via Giustiniani 2, Padua, Italy
    Blood 117:1707-9. 2011
    Whether long-term use of vitamin K antagonists (VKAs) might affect the incidence of cancer is a longstanding hypothesis...
  98. ncbi Vitamin K antagonists and pregnancy outcome. A multi-centre prospective study
    Christof Schaefer
    Pharmakovigilanz und Beratungszentrum für Embryonaltoxikologie, Berliner Betrieb für Zentrale Gesundheitliche Aufgaben, Spandauer Damm 130, Haus 10, 14050 Berlin, Germany
    Thromb Haemost 95:949-57. 2006
    b>Vitamin K antagonists (VKA) are known to act as teratogens; however, there is still uncertainty about the relative risk for birth defects and the most sensitive period...
  99. pmc Bone health. New role for vitamin K?
    Milly Ryan-Harshman
    FEAST Enterprises, Oshawa, Ont
    Can Fam Physician 50:993-7. 2004
    To assess growing evidence that vitamin K (phylloquinone) plays an important role in bone health and, subsequently, in prevention of osteoporotic fractures.
  100. ncbi Prospective study of supplemental vitamin K therapy in patients on oral anticoagulants with unstable international normalized ratios
    Sarah K Ford
    Department of Pharmacy, University of North Carolina Hospitals, Chapel Hill, NC 27599, USA
    J Thromb Thrombolysis 24:23-7. 2007
    It is not known whether patients on oral vitamin K antagonists who have unstable INRs achieve more stable INRs with daily vitamin K supplementation...

Research Grants63

  1. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..as a single polypeptide precursor which undergoes a series of post-translational modifications (PTMs), including vitamin K dependent 3-carboxylation, to form a mature two-chain zymogen which circulates in plasma and can be converted to ..
  2. Regulation of glucose metabolism by bone resorption and gamma-carboxylation
    Mathieu Ferron; Fiscal Year: 2012
    ..goal of the R00 independent phase of this application is to understand how ?-carboxylation, a process requiring vitamin K can regulate glucose homeostasis. This question will be addressed by two specific aims...
  3. Microbial Diversity in Mechanisms of Disulfide Bond Formation and Reduction
    Dana Boyd; Fiscal Year: 2013
    ..Many other bacteria, including Mycobacterium tuberculosis (Mtb), appear to use a homologue of human vitamin K epoxide reductase, VKOR, for disulfide bond formation instead of DsbB. Mtb VKOR can substitute for DsbB in E...
  4. Intralipid: A novel frontline countermeasure for brodifacoum poisoning
    Douglas L Feinstein; Fiscal Year: 2013
    ..They potently reduce vitamin K levels throughout the body by inhibiting its recycling leading to loss of activity of Vitamin K dependent ..
  5. Blood Coagulation Protein - Metal Ion - Lipid Interactions
    Francis J Castellino; Fiscal Year: 2013
    ..during a more than a 30-year period of continual funding are to define structure-function relationships of vitamin K-dependent coagulation proteins, both in vitro and in vivo, with specific attention paid to interactions of the g-..
  6. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2013
    The vitamin K cycle supports blood coagulation and is a major target for anticoagulation drugs. Coagulation factors require Dcarboxylation of glutamic acids for activation at sites of injury...
  7. Physiology and Molecular Biology of Factor XI
    David Gailani; Fiscal Year: 2013
    ..FXI has a number of structural features that distinguish it from vitamin K-dependent coagulation proteases...
  8. Comprehensive studies of novel SNPs affecting warfarin dose in African Americans
    Minoli Perera; Fiscal Year: 2012
    ..regulation, and to show the effect of these SNPs on both the pharmacokinetics of warfarin and its drug target Vitamin K epoxide reductase (VKOR)...
  9. Bone metabolism and bone metastases in prostate cancer
    Kathryn M Wilson; Fiscal Year: 2013
    ..for advanced prostate cancer, including obesity and dietary factors like calcium, vitamin D, phosphorus, and vitamin K, may impact prostate cancer progression through their effects on tumor expression of bone-related genes and on ..
  10. Protease Activated Receptor Signaling by Coagulation Proteases
    Alireza R Rezaie; Fiscal Year: 2013
    ..specificity of coagulation proteases under conditions in which endothelial cells have been pre-incubated with vitamin K-dependent coagulation zymogens so that to occupy EPCR or other potential receptors by their natural ligands...
  11. Vitamin K Oxidoreductase: function and physiology
    KATHLEEN LUCILE BERKNER; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The vitamin K oxidoreductase (VKOR) plays a critical role in hemostasis because it provides the cofactor required for the carboxylation of vitamin K-dependent (VKD) hemostatic proteins...
  12. Vitamin K, Knee Osteoarthritis, and Physical Function in Older Adults
    Richard F Loeser; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A growing body of evidence suggests that vitamin K insufficiency is associated with several age-related diseases, including osteoarthritis (OA)...
  13. Osteocalcin as a regulator of energy metabolism
    Gerard Karsenty; Fiscal Year: 2012
    ..To generate mice lacking, in osteoblasts only, the Vitamin K epoxy reductase C1, another enzyme involved in carboxylation of osteocalcin 3...
  14. BIOCHEMISTRY AND MORPHOLOGY OF CONNECTIVE TISSUE
    Jouni Uitto; Fiscal Year: 2013
    ..on expansion of the ABCC6 mutation database and exploration of the genetic heterogeneity with respect to vitamin K-dependent genes GGCX and VKORC...
  15. Axl as a target for the therapy of pancreatic cancer
    Rolf A Brekken; Fiscal Year: 2013
    ..Axl is activated by a single ligand, the vitamin K-dependent gamma-carboxyglutamic (GLA) domain protein, Gas6...
  16. Inhibitory targeting of HHV-8 vIL-6-related interactions.
    John Nicholas; Fiscal Year: 2013
    ..is not understood, but we have identified a functionally important interaction of vIL-6 with a novel protein, vitamin K epoxide reductase complex subunit 1 variant-2 (VKORC1v2), and also have recently determined that the IL-6 signal ..
  17. Structure and Function of the Gamma Carboxylase
    KATHLEEN LUCILE BERKNER; Fiscal Year: 2013
    ..provided by applicant): The gamma-glutamyl carboxylase generates carboxylated Glus (Glas) in the Gla domain of vitamin K- dependent (VKD) proteins to render them active in a diverse range of functions that includes hemostasis, ..
  18. Molecular, Structural &Clinical Aspects of Vitamin K-Dependent Proteins
    SARAH LOUISE BOOTH; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): Vitamin K (VK) was discovered for its role in hemostasis, and requirements were historically based on the amount required for normal blood coagulation...
  19. Characterization of ER-localized Activity of HHV-8 Interleukin-6
    EMILY MARIE COUSINS; Fiscal Year: 2013
    ..However, we have recently identified a novel interaction partner of vIL-6, vitamin K epoxide reductase complex subunit 1 variant 2 (VKORC1v2), which also localizes to the ER and functions to ..
  20. Contemporary Treatment and Outcomes for Atrial Fibrillation in Clinical Practice
    DANIEL EDWIN SINGER; Fiscal Year: 2010
    ..Numerous randomized controlled trials in selected populations have compared stroke prevention strategies (e.g., vitamin K antagonists, antiplatelet agents, other) and pharmacologic arrhythmia control, and numerous earlier phase ..
  21. PROTEIN Z DEPENDENT PROTEINASE INHIBITOR
    George J Broze; Fiscal Year: 2011
    Protein Z (PZ) is a vitamin K-dependent plasma protein that serves as a cofactor for the inhibition of factor Xa by PZ-dependent Protease Inhibitor (ZPI)...
  22. Predictors and Consequences of Subchondral Bone Attrition in Osteoarthritis
    Tuhina Neogi; Fiscal Year: 2011
    ..In this research environment, I've already begun to explore the association of vitamin K, a nutritional factor with bone effects, with OA in collaboration with Dr...
  23. Genetic and Environmental Determinants of Warfarin Response
    Nita A Limdi; Fiscal Year: 2012
    ..001) to test three hypotheses. This proposal will incorporate 50 genes involved in the clotting cascade, vitamin K cycle, and warfarin pharmacodynamics and pharmacokinetics...
  24. Structural and Biochemical Basis of the Vitamin K cycle
    Weikai Li; Fiscal Year: 2010
    ..Subsequent studies to dissect the function of identified asthma susceptibility genes in murine and human populations will form the basis of future R01 applications, assisting in the transition to scientific independence. ..
  25. New Vistas in Vitamin K Metabolism
    ALLAN EDWARD RETTIE; Fiscal Year: 2013
    ..The long-term aim of this research is to define the network of integrated metabolic events that underlie vitamin K anabolism and catabolism, in order to understand inter-subject variability in response to this essential dietary ..
  26. Characterization of Vitamin K Epoxide Reductase
    Darrel W Stafford; Fiscal Year: 2013
    ..applicant): The long-term objective of this project is to understand, not only the structure and function of the vitamin K epoxide reductase (VKOR), but also the vitamin K cycle as a whole...
  27. Pseudoxanthoma Elasticum Research 2010 Conference
    Sharon F Terry; Fiscal Year: 2011
    ..in preparation for clinical trials, and evaluate a number of hypothetical therapeutic interventions including vitamin K therapy and anti-angiogensis therapies...
  28. Identifying Vitamin K Dependent Pathways in Osteoarthritis Progression
    MARY KYLA SHEA; Fiscal Year: 2013
    ..Observational studies suggest vitamin K insufficiency is associated with greater risk for OA...
  29. METAL DEPENDENT COMPLEXES IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2002
    ..from the application) There have been many advances in understanding structure/function relationships in vitamin K-dependent proteins including the Gla domains in the ten years since the last renewal of this application...
  30. Extending the applications of hydrogen exchange mass spectrometry
    John R Engen; Fiscal Year: 2013
    ..These tools would then be applied by ourselves and in coordination with others to study a huge variety of proteins, protein complexes, and problems in the fields of protein science and medicine. ..
  31. Structure/Function Study of the Anticoagulant Protein S
    Alan Rigby; Fiscal Year: 2005
    ..Protein S, is a vitamin K-dependent protein that possesses both APC-dependent and APC-independent anticoagulant activity...
  32. Structure, Function &Genetics of Coagulation Factors
    Darrel W Stafford; Fiscal Year: 2013
    ..and in vivo models to focus on the mechanism of action of FVIIa and FIX as well as studying the reductant for vitamin K epoxide reductase. Dr...
  33. VITAMIN K-DEPENDENT PROTEINS IN LIVER & ISOLATED CELLS
    Reidar Wallin; Fiscal Year: 1992
    The long-term objective of this proposal is to understand vitamin K-dependent biosynthesis of proteins and how these processes are regulated...
  34. VITAMIN K AND SKELETAL HEALTH
    Neil Binkley; Fiscal Year: 2000
    ..As at least three vitamin K dependent skeletal proteins exist, it is plausible that vitamin K plays a role in the maintenance of skeletal ..
  35. MOLECULAR BASIS OF COAGULATION PROTEASE SPECIFICITY
    Alireza R Rezaie; Fiscal Year: 2010
    ..The cascade is initiated and propagated by the successive activations of the vitamin K-dependent zymogens, factors VII, IX, X and prothrombin;and the non- enzymatic cofactors Va and VIlla that ..
  36. ROLE OF METAL IONS IN THE FUNCTION OF HUMAN FACTOR IX
    Howard Liebman; Fiscal Year: 1992
    Factor IX is a vitamin K-dependent blood coagulation protein whose function is essential to normal hemostasis...
  37. VITAMIN K-DEPENDENT PROTEINS IN BLOOD AND DEVELOPMENT
    David Roth; Fiscal Year: 2001
    In what is the only known biological process dependent on vitamin K, the vitamin K-dependent lambda-glutamyl carboxylase catalyzes the posttranslational modification of glutamate to lambda-carboxyglutamate in the vitamin K-dependent ..
  38. ACQUISITION OF NMR SPECTROMETER
    William Bachovchin; Fiscal Year: 1991
    ..A major goal to determine the structural basis for immune recognition of helical nucleic acid structures. (iii) Vitamin K dependent carboxylation of prothrombin...
  39. METABOLISM OF NONCOLLAGENOUS BONE PROTEINS
    SATORU NISHIMOTO; Fiscal Year: 1992
    Two related questions are investigated in this proposal. First, what is the biological function of the vitamin K-dependent, bone specific protein, bone Gla protein (BGP, Osteocalcin)? BGP is an abundant, noncollagenous protein which ..
  40. Ketamine Injection and HIV Risk Among High Risk Youth
    STEPHEN LANKENAU; Fiscal Year: 2006
    Parochially known as "Special K," "Vitamin K," or simply "K," ketamine is a conger of phencyclidine (PCP)...
  41. PERINATAL DEVELOPMENT OF VITAMIN K-DEPENDENT HEMOSTASIS
    Edwin Bovill; Fiscal Year: 1993
    Although all neonates are severely Vitamin K deficient at birth by comparison with adults, some will have abnormalities of vitamin K-dependent hemostasis...
  42. Vitamin K and Bone in Children with Cerebral Palsy
    CHRISTOPHER MODLESKY; Fiscal Year: 2007
    ..One factor that is closely tied to fracture but has not been evaluated in children with CP is vitamin K status. Vitamin K is necessary for the carboxylation of osteocalcin...
  43. MEMBRANE PROTEINS IN BLOOD COAGULATION
    Barbara Furie; Fiscal Year: 2003
    ..investigation of the synthesis of g-carboxyglutamic acid in the membrane binding Gla domain of the vitamin K-dependent blood clotting proteins and the mechanism by which blood clotting proteins assemble on membrane ..
  44. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT OLIVIER MOSNIER; Fiscal Year: 2010
    ..of thrombotic and inflammatory disorders by studying novel mechanisms for cytoprotective actions of vitamin K-dependent coagulation proteases...
  45. Direct Cellular Effects of Blood Coagulation Proteases
    LAURENT MOSNIER; Fiscal Year: 2007
    ..of thrombotic and inflammatory disorders by studying novel mechanisms for cytoprotective actions of vitamin K-dependent coagulation proteases...
  46. In vivo assessment of Gas6 to protect oligodendrocytes and enhance remyelination
    Bridget Shafit Zagardo; Fiscal Year: 2009
    ..Among the cDNAs identified were members of the receptor tyrosine kinase family, Axl, Rse, and Mer. The ligand, vitamin K-dependent growth-arrest specific protein 6 (gas6), activates the Axl, Rse, and Mer receptors and protects ..
  47. FACTOR II ANTIGEN AND COAGULANT ACTIVITY
    JAMES CORRIGAN; Fiscal Year: 1980
    ..These particular factors are dependent upon vitamin K for their synthesis...
  48. Dose-finding, pharmacokinetic, safety and efficacy of bivalirudin in children
    Guy Young; Fiscal Year: 2009
    ..are treated with so- called standard anticoagulants, mostly heparin, low molecular weight heparins, and oral vitamin K antagonists. There are significant limitations to these agents which are accentuated in children...
  49. HIV RISK AND KETAMINE INJECTION AMONG HIGH RISK YOUTH
    STEPHEN LANKENAU; Fiscal Year: 2001
    ..Ketamine hydrochloride (informally known as "Special K," "Vitamin K," "ketamine," or simply "K") is a congener of phencyclidine (PCP) that produces both psychological effects, such ..
  50. BIOSYNTHESIS OF BLOOD CLOTTING PROTEINS
    Bruce Furie; Fiscal Year: 2001
    DESCRIPTION: (Adapted from investigator's abstract) The vitamin K-dependent blood coagulation proteins undergo co- or post-translational processing that includes gamma carboxylation...
  51. CANCER-INDUCED COAGULATION--MONOCYTES/HYALURONIC ACID
    Maria McGee; Fiscal Year: 1992
    ..The family of vitamin K-dependent gamma- carboxylated proteins synthesized by carcinoma cells will be purified and characterized from ..
  52. MECHANISM OF ACTION OF VITAMIN K AND ANTICOAGULANTS
    Robert Bell; Fiscal Year: 1980
    There is substantial evidence that the vitamin K-epoxide cycle is involved in the synthesis of prothrombin. Agents which block either the regeneration of vitamin K from vitamin K epoxide or the epoxidation of vitamin K are anticoagulants...
  53. BIOMARKERS OF AGING--CIRCULATING/DEPOSITED OSTEOCALCIN
    PAUL GALLOP; Fiscal Year: 1992
    Osteocalcin (OC), a vitamin K-dependent protein is made specifically by osteoblasts...
  54. FACTOR IX--MOLECULAR DEFECTS & REGULATION OF EXPRESSION
    Katherine High; Fiscal Year: 1991
    Factor IX is a vitamin K dependent plasma protein synthesized in the liver and required for normal coagulation...
  55. Diet and Risk of Hip Fractures in Men
    Diane Feskanich; Fiscal Year: 2009
    ..The dietary factors to be studied in detail include nutrient intakes of calcium, vitamin D, retinol, and vitamin K, and food consumption of milk, dairy, fruits, and vegetables...
  56. ENHANCED VITAMIN K DEPENDENT PROTEINS
    Gary Nelsestuen; Fiscal Year: 2002
    DESCRIPTION: (Investigator's abstract) This study will examine vitamin K-dependent proteins that display improved membrane affinity. The vitamin K-dependent plasma proteins function in both pro- and anti-coagulation pathways...
  57. THE MECHANISM OF ACTION OF VITAMIN K
    ALLAN WILLINGHAM; Fiscal Year: 1980
    The objective of this project is to study the vitamin K-dependent formation of gamma-carboxyglutamate residues in hepatic precursor proteins...
  58. FASEB Conference:Vitamin K&Synthesis,Structure,Function
    Jane Lian; Fiscal Year: 2001
    DESCRIPTION (provided by applicant) This proposal is for partial support of a conference on Vitamin K and Vitamin K-Dependent Proteins that is being held under the auspices of the Federation of American Scientists for Experimental ..
  59. RESEARCH TRAINING PROGRAM IN NUTRITION AND AGING
    Robert Russell; Fiscal Year: 1999
    ..research, lipid metabolism, mineral bioavailability, nutritional immunology, exercise, vitamin metabolism, and vitamin K. Since the original funding of this NIA training grant, two courses have been developed on nutrition and aging; ..
  60. STRUCTURE AND FUNCTION OF BOVINE PROTEIN Z
    Gary Wood; Fiscal Year: 1990
    ..Protein Z is a-member of the vitamin K-dependent family of plasma proteins...
  61. NUTRITIONAL ROLE OF VITAMIN K: K DEPENDENT CARBOXYLASE
    EUGENE SANDER; Fiscal Year: 1980
    b>Vitamin K is an essential nutrient in the diet of humans. Its role in the posttranslation carboxylation of blood-coagulation proteins and other proteins involved in the mineralization of bone has only recently been elucidated...
  62. PROTEIN C STRUCTURE/FUNCTION & RISK OF THROMBOSIS
    JOSEPH MILETICH; Fiscal Year: 1993
    The activity of Protein C, a vitamin K dependent plasma glycoprotein, is the key element of a naturally occurring, tonically active anticoagulation pathway...
  63. FASEB CONFERENCE--VITAMIN K-DEPENDENT PROTEINS
    John Suttie; Fiscal Year: 1990
    This is an application for partial funding of a conference on the Synthesis and Functions of Vitamin K-dependent Proteins...