phloroglucinol

Summary

Summary: 1,3,5-Benzenetriol. A trinitrobenzene derivative with antispasmodic properties that is used primarily as a laboratory reagent.

Top Publications

  1. ncbi Hyperforin: more than an antidepressant bioactive compound?
    Miguel A Medina
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, E 29071 Malaga, Spain
    Life Sci 79:105-11. 2006
  2. ncbi Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells
    Chang Suk Kong
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Food Chem Toxicol 47:1653-8. 2009
  3. ncbi Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo
    Kyoung Ah Kang
    Jeju National University School of Medicine and Applied Radiological Science Research Institute, Jeju si 690 756, Republic of Korea
    Chem Biol Interact 185:215-26. 2010
  4. ncbi In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms
    Lizandra G Magalhaes
    Departamento de Bioquimica e Imunologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Parasitol Res 106:395-401. 2010
  5. ncbi The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways
    Dah Yuu Lu
    Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan
    Phytomedicine 19:1093-100. 2012
  6. ncbi Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer
    Ssu Ming Huang
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    J Cell Biochem 112:643-52. 2011
  7. ncbi Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy
    J Nat Prod 70:608-12. 2007
  8. ncbi Hyperforin in St. John's wort drug interactions
    Rajanikanth Madabushi
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O 100494, Gainesville, 32610, USA
    Eur J Clin Pharmacol 62:225-33. 2006
  9. ncbi Evolutionary history of synthesis pathway genes for phloroglucinol and cyanide antimicrobials in plant-associated fluorescent pseudomonads
    Michele Frapolli
    Plant Pathology, Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    Mol Phylogenet Evol 63:877-90. 2012
  10. ncbi Effect of phloroglucinol on oxidative stress and inflammation
    Moon Moo Kim
    Department of Chemistry, Dong Eui University, Busan 614 714, Republic of Korea
    Food Chem Toxicol 48:2925-33. 2010

Research Grants

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
  2. CYROBIOLOGICAL PRESERVATION OF ANOPHELES EMBRYOS
    Peter Mazur; Fiscal Year: 2001
  3. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
  4. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  6. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010

Detail Information

Publications265 found, 100 shown here

  1. ncbi Hyperforin: more than an antidepressant bioactive compound?
    Miguel A Medina
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, E 29071 Malaga, Spain
    Life Sci 79:105-11. 2006
    ..They include other neurological effects, effects on inflammation, as well as antibacterial, antitumoral and antiangiogenic effects...
  2. ncbi Induction of apoptosis by phloroglucinol derivative from Ecklonia Cava in MCF-7 human breast cancer cells
    Chang Suk Kong
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    Food Chem Toxicol 47:1653-8. 2009
    b>Phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3',5'-dihydroxyphenoxy)-7-(2'',4'',6-trihydroxyphenoxy)-2,4,9-trihydroxydibenzo-1,4-dioxin (2), were isolated from Ecklonia Cava...
  3. ncbi Phloroglucinol (1,3,5-trihydroxybenzene) protects against ionizing radiation-induced cell damage through inhibition of oxidative stress in vitro and in vivo
    Kyoung Ah Kang
    Jeju National University School of Medicine and Applied Radiological Science Research Institute, Jeju si 690 756, Republic of Korea
    Chem Biol Interact 185:215-26. 2010
    ..We have investigated the radioprotective effect of phloroglucinol (1,3,5-trihydroxybenzene), phlorotannin compound isolated from Ecklonia cava, against gamma-ray radiation-..
  4. ncbi In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult worms
    Lizandra G Magalhaes
    Departamento de Bioquimica e Imunologia, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, 14049 900 Ribeirao Preto, SP, Brazil
    Parasitol Res 106:395-401. 2010
    ..The aim of this work was to evaluate the in vitro schistosomicidal activity of some phloroglucinol compounds, obtained from the rhizomes of Dryopteris species, against Schistosoma mansoni adult worms...
  5. ncbi The novel phloroglucinol derivative BFP induces apoptosis of glioma cancer through reactive oxygen species and endoplasmic reticulum stress pathways
    Dah Yuu Lu
    Graduate Institute of Neural and Cognitive Sciences, China Medical University, Taichung, Taiwan
    Phytomedicine 19:1093-100. 2012
    Prenyl-phloroglucinol derivatives from hop plants have been shown to have anticancer activities...
  6. ncbi Phloroglucinol derivative MCPP induces cell apoptosis in human colon cancer
    Ssu Ming Huang
    Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan
    J Cell Biochem 112:643-52. 2011
    This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (3,6-bis(3-chlorophenylacetyl)phloroglucinol; MCPP) in human colon cancer cells...
  7. ncbi Arzanol, an anti-inflammatory and anti-HIV-1 phloroglucinol alpha-Pyrone from Helichrysum italicum ssp. microphyllum
    Giovanni Appendino
    Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Universita del Piemonte Orientale, Via Bovio 6, 28100 Novara, Italy
    J Nat Prod 70:608-12. 2007
    An acetone extract of Helichrysum italicum ssp. microphyllum afforded the phloroglucinol alpha-pyrone arzanol (1a) as a potent NF-kappaB inhibitor. Arzanol is identical with homoarenol (2a), whose structure should be revised...
  8. ncbi Hyperforin in St. John's wort drug interactions
    Rajanikanth Madabushi
    Department of Pharmaceutics, College of Pharmacy, University of Florida, P O 100494, Gainesville, 32610, USA
    Eur J Clin Pharmacol 62:225-33. 2006
    ..In the present paper clinical significant SJW interactions are critically evaluated against the background of hyperforin...
  9. ncbi Evolutionary history of synthesis pathway genes for phloroglucinol and cyanide antimicrobials in plant-associated fluorescent pseudomonads
    Michele Frapolli
    Plant Pathology, Institute of Integrative Biology, ETH Zurich, CH 8092 Zurich, Switzerland
    Mol Phylogenet Evol 63:877-90. 2012
    ....
  10. ncbi Effect of phloroglucinol on oxidative stress and inflammation
    Moon Moo Kim
    Department of Chemistry, Dong Eui University, Busan 614 714, Republic of Korea
    Food Chem Toxicol 48:2925-33. 2010
    The aim of this study is to investigate the inhibitory effect of phloroglucinol on oxidative stress and inflammation. Phloroglucinol is a monomer of phlorotannins abundant in brown algae...
  11. pmc Characterization of interactions between the transcriptional repressor PhlF and its binding site at the phlA promoter in Pseudomonas fluorescens F113
    Abdelhamid Abbas
    BIOMERIT Research Centre, National University of Ireland, Cork, Ireland
    J Bacteriol 184:3008-16. 2002
    ..Conversely, the PhlF-phO complex is stabilized by the presence of salicylate, which has been shown to be an inhibitor of phlA expression...
  12. ncbi Anti-apoptotic and growth-stimulatory functions of CK1 delta and epsilon in ductal adenocarcinoma of the pancreas are inhibited by IC261 in vitro and in vivo
    C Brockschmidt
    Clinic of General, Visceral and Transplantation Surgery, University of Ulm, Steinhovelstr 9, 89075 Ulm, Germany
    Gut 57:799-806. 2008
    ..Pancreatic ductal adenocarcinomas (PDACs) are highly resistant to treatment due to changes in various signalling pathways. CK1 isoforms play important regulatory roles in these pathways...
  13. pmc Binding of arabinogalactan proteins by Yariv phenylglycoside triggers wound-like responses in Arabidopsis cell cultures
    Yu Guan
    Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Plant Physiol 135:1346-66. 2004
    ..It remains uncertain whether the Yariv phenylglycoside cross-linking of cell surface AGPs induces these genes through a specific AGP-based signaling mechanism or through a general mechanical perturbation of the cell surface...
  14. pmc Microbial products trigger amino acid exudation from plant roots
    Donald A Phillips
    Department of Agronomy and Range Science, University of California, Davis, CA 95616, USA
    Plant Physiol 136:2887-94. 2004
    ..The importance of identifying potential enhancers of root exudation lies in understanding that such compounds may represent regulatory linkages between the larger soil food web and the internal carbon metabolism of the plant...
  15. pmc The sigma factor sigma s affects antibiotic production and biological control activity of Pseudomonas fluorescens Pf-5
    A Sarniguet
    Institut National de la Recherche Agronomique, Centre de Recherches de Rennes, Le Rheu, France
    Proc Natl Acad Sci U S A 92:12255-9. 1995
    ..The RpoS- mutant overproduced pyoluteorin and 2,4-diacetyl-phloroglucinol, two antibiotics that inhibit growth of the phytopathogenic fungus Pythium ultimum, and was superior to the ..
  16. ncbi Identification of quantitative trait loci influencing foliar concentrations of terpenes and formylated phloroglucinol compounds in Eucalyptus nitens
    Martin L Henery
    School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia
    New Phytol 176:82-95. 2007
    ..Leaves of eucalypt species contain a variety of plant secondary metabolites, including terpenoids and formylated phloroglucinol compounds (FPCs)...
  17. ncbi Effect of the hfq gene on 2,4-diacetylphloroglucinol production and the PcoI/PcoR quorum-sensing system in Pseudomonas fluorescens 2P24
    Xiao Gang Wu
    Department of Plant Pathology, China Agricultural University, Beijing, China
    FEMS Microbiol Lett 309:16-24. 2010
    ..Based on these results, we propose that Hfq functions as an important regulatory element in the complex network controlling environmental adaption in P. fluorescens 2P24...
  18. ncbi Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2
    Claudia Gey
    Institut fur Organische Chemie, Universitat Leipzig, Johannisallee 29, 04103 Leipzig, Germany
    Angew Chem Int Ed Engl 46:5219-22. 2007
  19. ncbi Arzanol, a prenylated heterodimeric phloroglucinyl pyrone, inhibits eicosanoid biosynthesis and exhibits anti-inflammatory efficacy in vivo
    Julia Bauer
    Department for Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    Biochem Pharmacol 81:259-68. 2011
    ..italicum, and a rationale for further pre-clinical evaluation of this novel anti-inflammatory lead...
  20. ncbi Antioxidant activity of two phloroglucinol derivatives from Dryopteris crassirhizoma
    Sang Myung Lee
    Laboratory of Immunomodulator, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Biol Pharm Bull 26:1354-6. 2003
    ..Two phloroglucinol derivatives, flavaspidic acids PB (1) and AB (2), were isolated from the rhizome of D...
  21. ncbi Pro-apoptotic properties of hyperforin in leukemic cells from patients with B-cell chronic lymphocytic leukemia
    C Quiney
    UMR 736 INSERM Université Paris VI, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    Leukemia 20:491-7. 2006
    The effects of the hyperforin (HF), a natural phloroglucinol purified from Hypericum perforatum, were investigated ex vivo on leukemic cells from patients with B-cell chronic lymphocytic leukemia (B-CLL)...
  22. ncbi Improved phloroglucinol production by metabolically engineered Escherichia coli
    Yujin Cao
    Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, 266101, Qingdao, China
    Appl Microbiol Biotechnol 91:1545-52. 2011
    b>Phloroglucinol is a valuable chemical which has been successfully produced by metabolically engineered Escherichia coli. However, the low productivity remains a bottleneck for large-scale application and cost-effective production...
  23. ncbi Biosynthesis of phloroglucinol compounds in microorganisms--review
    Fang Yang
    Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, 315201, Ningbo, China
    Appl Microbiol Biotechnol 93:487-95. 2012
    b>Phloroglucinol derivatives are a major class of secondary metabolites of wide occurrence in biological systems. In the bacteria kingdom, these compounds can only be synthesized by some species of Pseudomonads. Pseudomonas spp...
  24. ncbi Antithrombotic and profibrinolytic activities of phloroglucinol
    Jong Sup Bae
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Kyungpook National University, 1370 Sankyuk Dong, Buk Gu, Daegu 702 701, Republic of Korea
    Food Chem Toxicol 49:1572-7. 2011
    b>Phloroglucinol is the monomeric units of phlorotannins abundant in brown algae...
  25. pmc Autoinduction of 2,4-diacetylphloroglucinol biosynthesis in the biocontrol agent Pseudomonas fluorescens CHA0 and repression by the bacterial metabolites salicylate and pyoluteorin
    U Schnider-Keel
    Laboratoire de Biologie Microbienne, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    J Bacteriol 182:1215-25. 2000
    ..This mechanism, which depends on phlF function, may help P. fluorescens to produce homeostatically balanced amounts of extracellular metabolites...
  26. ncbi Antiplatelet effect of phloroglucinol is related to inhibition of cyclooxygenase, reactive oxygen species, ERK/p38 signaling and thromboxane A2 production
    Mei Chi Chang
    Biomedical Science Team, Chang Gung University of Science and Technology, Taoyuan, Taiwan
    Toxicol Appl Pharmacol 263:287-95. 2012
    ..Many antiplatelet agents are used for prevention and treatment of these diseases. In this study, phloroglucinol (2...
  27. ncbi Evaluation of the antioxidant and cytotoxic activity of arzanol, a prenylated alpha-pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp.microphyllum
    Antonella Rosa
    Dipartimento di Biologia Sperimentale, Sez Patologia Sperimentale, Universita degli Studi di Cagliari, Cittadella Universitaria, SS 554, Km 4 5, 09042 Monserrato, Cagliari, Italy
    Chem Biol Interact 165:117-26. 2007
    ..Arzanol, a pyrone-phloroglucinol etherodimer, and helipyrone, a dimeric pyrone, showed antioxidant activity, and could protect linoleic acid ..
  28. pmc The key role of phloroglucinol O-methyltransferase in the biosynthesis of Rosa chinensis volatile 1,3,5-trimethoxybenzene
    Shuiqin Wu
    Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Shizuoka 422 8529, Japan
    Plant Physiol 135:95-102. 2004
    ..This compound is synthesized in three successive methylation steps from phloroglucinol, the initial precursor...
  29. ncbi Quantitative trait loci for key defensive compounds affecting herbivory of eucalypts in Australia
    J S Freeman
    School of Plant Science and CRC for Forestry, University of Tasmania, Private Bag 55, Hobart, Tasmania, Australia
    New Phytol 178:846-51. 2008
    ..Given the potential widespread occurrence of these QTL, their ontogenetic stability, and their impact on a range of dependent herbivores, it is possible that they have extended phenotypic effects in the Australian forest landscape...
  30. ncbi Phloroglucinol compounds of therapeutic interest: global patent and technology status
    Inder Pal Singh
    National Institute of Pharmaceutical Education and Research, Department of Natural Products, Sector 67, S A S Nagar, Punjab 160062, India
    Expert Opin Ther Pat 19:847-66. 2009
    b>Phloroglucinol compounds, both synthetic as well as natural, have shown a vast array of biological activities...
  31. ncbi Hyperforin and aristoforin inhibit lymphatic endothelial cell proliferation in vitro and suppress tumor-induced lymphangiogenesis in vivo
    Melanie Rothley
    Forschungszentrum Karlsruhe, Institut für Toxikologie und Genetik, Postfach 3640, Karlsruhe, Germany
    Int J Cancer 125:34-42. 2009
    The phloroglucinol derivative hyperforin, a major bioactive constituent of St. John's wort, is increasingly recognized as being able to regulate a variety of pathobiological processes and, thus, to possess potential therapeutic properties...
  32. pmc CK1epsilon is required for breast cancers dependent on beta-catenin activity
    So Young Kim
    Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8979. 2010
    ..Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date...
  33. ncbi Hyperforin--a key constituent of St. John's wort specifically activates TRPC6 channels
    Kristina Leuner
    Pharmakologisches Institut für Naturwissenschaftler, Biocenter Niederursel, 60438 Frankfurt, Germany
    FASEB J 21:4101-11. 2007
    ..Hyperforin integrates inhibition of neurotransmitter uptake and neurotrophic property by specific activation of TRPC6 and represents an interesting lead-structure for a new class of antidepressants...
  34. ncbi Heritable variation in the foliar secondary metabolite sideroxylonal in Eucalyptus confers cross-resistance to herbivores
    Rose L Andrew
    School of Botany and Zoology, The Australian National University, Canberra, ACT 0200, Australia
    Oecologia 153:891-901. 2007
    ....
  35. pmc Inhibition of casein kinase 1-epsilon induces cancer-cell-selective, PERIOD2-dependent growth arrest
    Wan Seok Yang
    Department of Biological Sciences, Columbia University, Fairchild Center, Amsterdam Avenue, New York, NY 10027, USA
    Genome Biol 9:R92. 2008
    ..Discovering novel kinases whose inhibition induces cancer-cell-selective lethality would be of value. Recent advances in RNA interference have enabled the realization of this goal...
  36. pmc Amplification of the housekeeping sigma factor in Pseudomonas fluorescens CHA0 enhances antibiotic production and improves biocontrol abilities
    U Schnider
    Laboratoire de Biologie Microbienne, Universite de Lausanne, Switzerland
    J Bacteriol 177:5387-92. 1995
    ....
  37. ncbi Analysis of proanthocyanidin cleavage products following acid-catalysis in the presence of excess phloroglucinol
    J A Kennedy
    Department of Horticulture, Viticulture and Oenology, University of Adelaide, Waite Campus, PMB 1, Glen Osmond, South Australia 5064, Australia
    J Agric Food Chem 49:1740-6. 2001
    The analysis of proanthocyanidin cleavage products after acid-catalysis in the presence of excess phloroglucinol was investigated. In the developed analytical method, a solution of 0...
  38. ncbi Hyperforin a constituent of St John's wort (Hypericum perforatum L.) extract induces apoptosis by triggering activation of caspases and with hypericin synergistically exerts cytotoxicity towards human malignant cell lines
    Katarina Hostanska
    Department of Internal Medicine, University Hospital Zurich, Zurich, Switzerland
    Eur J Pharm Biopharm 56:121-32. 2003
    ..Cytocidal effects of HP and its cooperation with HY on tumor growth inhibition in a synergistic manner make the St John's wort an interesting option in cancer warranting further in vitro and in vivo investigation...
  39. ncbi Protective effect of phlorotannin components phloroglucinol and eckol on radiation-induced intestinal injury in mice
    Changjong Moon
    College of Veterinary Medicine, Chonnam National University, Gwangju 500 757, South Korea
    Phytother Res 22:238-42. 2008
    ..The radioprotective effects of two of the components of phlorotannin, phloroglucinol and eckol, in intestinal stem cells were examined by evaluating their effects on jejunal crypt survival and ..
  40. ncbi In vitro metabolism of hyperforin in rat liver microsomal systems
    Yanyan Cui
    National Center for Toxicological Research, Food and Drug Administration, 3900 NCTR Road, Jefferson, AR 72079, USA
    Drug Metab Dispos 32:28-34. 2004
    ....
  41. ncbi The role of arabinogalactan proteins binding to Yariv reagents in the initiation, cell developmental fate, and maintenance of microspore embryogenesis in Brassica napus L. cv. Topas
    Xing Chun Tang
    Key Laboratory of the MOE for the Development Biology, College of Life Science, Wuhan University, Wuhan 430072 China
    J Exp Bot 57:2639-50. 2006
    ..In addition, these proteins may also be involved in the regulation of root generation...
  42. ncbi Biomimetic synthesis and anti-HIV activity of dimeric phloroglucinols
    Siddheshwar K Chauthe
    Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, S A S Nagar, Punjab 160 062, India
    Bioorg Med Chem 18:2029-36. 2010
    ..Compounds 22 and 24 showed highest anti-HIV activity with an IC(50) of 0.28 microM and 2.71 microM, respectively, former was more active than the positive standard AZT in cell based assay...
  43. ncbi RpoN (sigma54) controls production of antifungal compounds and biocontrol activity in Pseudomonas fluorescens CHA0
    Maria Péchy-Tarr
    Department de Microbiologie Fondamentale, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Mol Plant Microbe Interact 18:260-72. 2005
    ..Taken together, our results establish RpoN for the first time as a major regulator of biocontrol activity in Pseudomonas fluorescens...
  44. ncbi Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation
    Kyoung Ah Kang
    Department of Biochemistry, College of Medicine and Applied Radiological Science Research Institute, Cheju National University, Jeju si 690 756, Korea
    J Cell Biochem 97:609-20. 2006
    We investigated the cytoprotective effect of phloroglucinol, which was isolated from Ecklonia cava (brown alga), against oxidative stress induced cell damage in Chinese hamster lung fibroblast (V79-4) cells...
  45. ncbi BFPP, a phloroglucinol derivative, induces cell apoptosis in human chondrosarcoma cells through endoplasmic reticulum stress
    Ju Fang Liu
    Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
    Biochem Pharmacol 79:1410-7. 2010
    ..This study is the first to investigate the anticancer effects of the new phloroglucinol derivative (2,4-bis(2-fluorophenylacetyl)phloroglucinol; BFPP) in human chondrosarcoma cells...
  46. ncbi Biosynthesis of phloroglucinol
    Jihane Achkar
    Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA
    J Am Chem Soc 127:5332-3. 2005
    Substantial concentrations of phloroglucinol were synthesized by Pseudomonas fluorescens Pf-5 expressing the plasmid-localized phlACBDE gene cluster responsible for biosynthesis of 2,4-diacetylphloroglucinol...
  47. ncbi Synthesis and ribonuclease A inhibition activity of resorcinol and phloroglucinol derivatives of catechin and epicatechin: Importance of hydroxyl groups
    Sansa Dutta
    Department of Chemistry, Indian Institute of Technology, Kharagpur 721 302, India
    Bioorg Med Chem 18:6538-46. 2010
    ..green tea extracts prompted us to synthesize novel catechin/epicatechin based conjugates with resorcinol and phloroglucinol with the aim to increase the number of phenolic OH groups...
  48. ncbi Protective role of arzanol against lipid peroxidation in biological systems
    Antonella Rosa
    Dip Biologia Sperimentale, Sez Patologia Sperimentale, Universita degli Studi di Cagliari, Cittadella Universitaria, SS 554, Km 4 5, 09042 Monserrato, Cagliari, Italy
    Chem Phys Lipids 164:24-32. 2011
    This study examines the protective effect of arzanol, a pyrone-phloroglucinol etherodimer from Helichrysum italicum subsp...
  49. ncbi Randomized trial of the efficacy of tamsulosin, nifedipine and phloroglucinol in medical expulsive therapy for distal ureteral calculi
    Marco Dellabella
    Department of Urology and Division of Urology, Azienda Ospedaliero Universitaria Ospedali Riuniti Umberto I G M Lancisi G Salesi, Polytechnic University of the Marche Region, School of Medicine, Ancona, Italy
    J Urol 174:167-72. 2005
    ..We performed a randomized, prospective study to assess and compare the efficacy of 3 drugs as medical expulsive therapy for distal ureteral calculi...
  50. ncbi Inhibition of tumour cell growth by hyperforin, a novel anticancer drug from St. John's wort that acts by induction of apoptosis
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Hauptstrasse 7, D 79104 Freiburg, Germany
    Oncogene 21:1242-50. 2002
    ....
  51. pmc Phloroglucinol inhibits the bioactivities of endothelial progenitor cells and suppresses tumor angiogenesis in LLC-tumor-bearing mice
    Yi Hong Kwon
    Department of Biomedical Science, Laboratory for Functional Foods and Nutrigenomics, CHA University, Kyunggi, Republic of Korea
    PLoS ONE 7:e33618. 2012
    There is increasing evidence that phloroglucinol, a compound from Ecklonia cava, induces the apoptosis of cancer cells, eventually suppressing tumor angiogenesis.
  52. pmc Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity
    Junghwa Ryu
    Department of Pharmacology and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Republic of Korea
    PLoS ONE 8:e71178. 2013
    In this study, we investigated whether phloroglucinol (1,3,5-trihydroxybenzene) has therapeutic effects in cellular and animal model of Parkinson's disease (PD)...
  53. pmc Genetic and environmental contributions to variation and population divergence in a broad-spectrum foliar defence of Eucalyptus tricarpa
    Rose L Andrew
    School of Botany and Zoology, The Australian National University, Canberra, ACT 0200, Australia
    Ann Bot 105:707-17. 2010
    ..Sideroxylonal (a formylated phloroglucinol compound or FPC) is an important chemical defence in eucalypts...
  54. ncbi Phloroglucinol (PG) purified from Ecklonia cava attenuates radiation-induced apoptosis in blood lymphocytes and splenocytes
    Suk Jae Park
    College of Veterinary Medicine and Applied Radiological Science Institute, Jeju National University, Jeju 690 756, Republic of Korea
    Food Chem Toxicol 49:2236-42. 2011
    b>Phloroglucinol (PG), a polyphenol compound of Eckloniacava known as brown algae abundant in Jeju island, has been proposed to exert the antioxidative and cytoprotective effects against oxidative stress...
  55. ncbi Phloroglucinol glycosides from the fresh fruits of Eucalyptus maideni
    Li Wen Tian
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People s Republic of China
    J Nat Prod 73:160-3. 2010
    Five new phloroglucinol glycosides, eucalmainosides A-E (1-5), were isolated from the fresh fruits of Eucalyptus maideni, along with 15 flavonoids (6-20), seven (+)-oleuropeic acid derivatives (15, 16, and 22-26), three hydrolyzable ..
  56. ncbi Phloroglucinol attenuates ultraviolet B radiation-induced matrix metalloproteinase-1 production in human keratinocytes via inhibitory actions against mitogen-activated protein kinases and activator protein-1
    Mei Jing Piao
    Jeju National University School of Medicine and Applied Radiological Science Research Institute, Jeju, South Korea
    Photochem Photobiol 88:381-8. 2012
    ..Recently, phloroglucinol (1,3,5-trihydroxybenzene) was demonstrated to attenuate the cell damage induced by oxidative stress by ..
  57. pmc Eucalyptus foliar chemistry explains selective feeding by koalas
    Ben D Moore
    School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia
    Biol Lett 1:64-7. 2005
    ..We tested whether a recently discovered group of plant secondary metabolites, the formylated phloroglucinol compounds (FPCs), deters koalas from feeding on some eucalypt foliage...
  58. ncbi Inhibitory effects of phloroglucinol derivatives isolated from Ecklonia stolonifera on Fc(epsilon)RI expression
    Sun Yup Shim
    Institute of Marine Life Science, Pukyong National University, Busan, Republic of Korea
    Bioorg Med Chem 17:4734-9. 2009
    Two bioactive phloroglucinol derivatives, dioxinodehydroeckol (DHE) and phlorofucofuroeckol A (PFF-A) were isolated from edible marine brown alga, Ecklonia stolonifera, and evaluated for effects on cell surface Fc(epsilon)RI expression in ..
  59. ncbi Antiplasmodial and cytotoxic activity of phloroglucinol derivatives from Hypericum erectum Thunb
    Hyung In Moon
    Inam Neuroscience Research Center, Wonkwang University, Sanbon Medical Center, Kyunggi Do, South Korea
    Phytother Res 24:941-4. 2010
    ..Five phloroglucinol derivatives, otogirin (1), otogirone (2), erectquione A (3), erectquione B (4), and erectquione C (5) were ..
  60. ncbi The resistance-nodulation-division efflux pump EmhABC influences the production of 2,4-diacetylphloroglucinol in Pseudomonas fluorescens 2P24
    Tao Tian
    Department of Plant Pathology, China Agricultural University, Beijing, 100193, PR China
    Microbiology 156:39-48. 2010
    ..In conclusion, our results suggest that the EmhABC system is an important element that influences the production of antibiotic 2,4-DAPG and enhances resistance to toxic compounds in P. fluorescens 2P24...
  61. ncbi Role of hyperforin in the pharmacological activities of St. John's Wort
    Paola Zanoli
    Department of Pharmaceutical Sciences, University of Moderna Reggio Emilia, 41100 Modena, Italy
    CNS Drug Rev 10:203-18. 2004
    The phloroglucinol derivative hyperforin has been recently shown to be a major antidepressant component in the extract of Hypericum perforatum...
  62. ncbi Effect of eluent pH on the HPLC-UV analysis of hyperforin from St. John's Wort (Hypericum perforatum L.)
    Jean Dominique Fourneron
    Laboratory of Galenic and Industrial Pharmacy, Faculty of Pharmacy, 27 Boulevard Jean Moulin, 13385 Marseille, France
    Phytochem Anal 17:71-7. 2006
    ....
  63. ncbi Hyperforin, a new lead compound against the progression of cancer and leukemia?
    C Quiney
    UMRS 736 INSERM Université Paris VI, Centre de Recherches Biomedicales des Cordeliers, Paris Cedex, France
    Leukemia 20:1519-25. 2006
    ..One of their main lipophilic components, a natural prenylated phloroglucinol termed hyperforin (HF), has been identified as the major molecule responsible for the antidepressant effects ..
  64. ncbi Active site binding modes of dimeric phloroglucinols for HIV-1 reverse transcriptase, protease and integrase
    Pawan Gupta
    Centre for Pharmacoinformatic, National Institute of Pharmaceutical Education and Research NIPER, S A S Nagar, Mohali, Punjab, India
    Bioorg Med Chem Lett 20:4427-31. 2010
    In a recent report on anti-HIV activity of dimeric phloroglucinol compounds, seven out of twenty one compounds were shown to possess good activity in HIV infected human CD4+ T cell line...
  65. ncbi Hyperforin inhibits P-gp and BCRP activities in chronic lymphocytic leukaemia cells and myeloid cells
    Claire Quiney
    UMRS 872 INSERM, Universite Paris 6, Centre de Recherche des Cordeliers, Paris, France
    Leuk Lymphoma 48:1587-99. 2007
    We showed previously that hyperforin (HF), a natural phloroglucinol, stimulated apoptosis in B cell chronic lymphocytic leukaemia cells (CLL) and displayed anti-angiogenic properties...
  66. ncbi O-4-Linked coniferyl and sinapyl aldehydes in lignifying cell walls are the main targets of the Wiesner (phloroglucinol-HCl) reaction
    F Pomar
    Department of Plant Biology, University of La Coruna, La Coruna
    Protoplasma 220:17-28. 2002
    The nature and specificity of the Wiesner test (phloroglucinol-HCl reagent) for the aromatic aldehyde fraction contained in lignins is studied...
  67. ncbi A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications
    Yoshihito Okada
    Department of Natural Medicine and Phytochemistry, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    J Nat Prod 67:103-5. 2004
    A new phloroglucinol derivative (1) and two known compounds (2 and 3) were isolated from the brown alga Eisenia bicyclis. These isolates exhibit inhibitory activity on glycation and alpha-amylase...
  68. ncbi Inhibition of casein kinase I delta alters mitotic spindle formation and induces apoptosis in trophoblast cells
    Martin Stöter
    Department of Visceral and Transplantation Surgery, University of Ulm, Ulm, Germany
    Oncogene 24:7964-75. 2005
    ..Our findings indicate that CKIdelta plays an important role in the mitotic progression and in the survival of cells of trophoblast origin. Therefore, IC261 could provide a new tool in treating choriocarcinomas...
  69. ncbi Hyperforin acts as an angiogenesis inhibitor
    Christoph M Schempp
    Department of Dermatology, University of Freiburg, Germany
    Planta Med 71:999-1004. 2005
    ..These data suggest that, in addition to the induction of tumor cell apoptosis, hyperforin can also suppress angiogenesis by a direct, non-toxic effect on endothelial cells...
  70. ncbi Localization of arabinogalactan proteins in egg cells, zygotes, and two-celled proembryos and effects of beta-D-glucosyl Yariv reagent on egg cell fertilization and zygote division in Nicotiana tabacum L
    Yuan Qin
    Key Laboratory of the Ministry of Education for Plant Developmental Biology, College of Life Sciences, Wuhan University, China
    J Exp Bot 57:2061-74. 2006
    ..The possible roles of AGPs in fertilization, zygotic division, and proembryo development are discussed...
  71. pmc Acute exacerbation of pain in irritable bowel syndrome: efficacy of phloroglucinol/trimethylphloroglucinol. A randomized, double-blind, placebo-controlled study
    O Chassany
    Département de la Recherche Clinique et du Développement, AP HP, Hopital Saint Louis, University Paris 7, Paris, France
    Aliment Pharmacol Ther 25:1115-23. 2007
    Abdominal pain is the predominant symptom in irritable bowel syndrome patients. Phloroglucinol and its methylated derivative are antispasmodic agents acting on smooth muscle.
  72. ncbi Matrix proteases, green tea, and St. John's wort: biomedical research catches up with folk medicine
    Rosy Caniato
    Department of Experimental Biomedical Sciences, Medical School of Padova, Italy
    Clin Chim Acta 381:69-77. 2007
    ..However, long before enzymes were first isolated, these same pathologies were being treated in plant-based folk remedies, and today science is screening them for their reputed beneficial effects...
  73. ncbi Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy
    T N Griffith
    CARE and CRCP, Biomedical, Center, P Universidad Catolica de Chile, P O Box 114 D, Santiago, Chile
    Curr Med Chem 17:391-406. 2010
    St. John's Wort (SJW) has been used medicinally for over 5,000 years. Relatively recently, one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest...
  74. ncbi Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease
    Anna Cabrelle
    Department of Clinical and Experiment Medicine, Medical School, Padova, Italy
    J Leukoc Biol 83:212-9. 2008
    ..Together, these properties qualify Hyp as a putative, therapeutic molecule for the treatment of autoimmune inflammatory disease sustained by Th1 cells, including EAE...
  75. ncbi Phloroglucinol mediates cross-talk between the pyoluteorin and 2,4-diacetylphloroglucinol biosynthetic pathways in Pseudomonas fluorescens Pf-5
    Teresa A Kidarsa
    USDA ARS Horticultural Crops Research Laboratory, Corvallis, OR 97330, USA
    Mol Microbiol 81:395-414. 2011
    ..The first step in DAPG biosynthesis is production of phloroglucinol (PG) by PhlD...
  76. ncbi Anti-allergic effects of phlorotannins on histamine release via binding inhibition between IgE and Fc epsilonRI
    Yong Li
    Marine Bioprocess Research Center, Pukyong National University, Busan 608 737, Republic of Korea
    J Agric Food Chem 56:12073-80. 2008
    Two bioactive phloroglucinol derivatives, fucodiphloroethol G (1) and phlorofucofuroeckol A (3) were first isolated from Eckolonia cava (EC) and characterized by nuclear magnetic resonance (NMR) spectroscopic methods, along with eckol (2)...
  77. ncbi Mechanisms of Hyperforin as an anti-angiogenic angioprevention agent
    Girieca Lorusso
    IRCCS Multimedica, Responsabile Ricerca Oncologica, via Fantoli 16 15, 20138 Milan, Italy
    Eur J Cancer 45:1474-84. 2009
    ....
  78. ncbi Investigation of the bioavailability of hypericin, pseudohypericin, hyperforin and the flavonoids quercetin and isorhamnetin following single and multiple oral dosing of a hypericum extract containing tablet
    Hans Ulrich Schulz
    LAFAA Laboratory for Contract Research in Clinical Pharmacology and Biopharmaceutical Analytics GmbH, Bad Schwartau Germany
    Arzneimittelforschung 55:15-22. 2005
    ..The kinetic characteristics of the hypericum flavonoids are reported here for the first time. The trial preparation was well tolerated...
  79. ncbi Phloroglucinol in irritable bowel syndrome
    Wasim Jafri
    Department of Medicine, Aga Khan University Hospital, Karachi
    J Pak Med Assoc 56:5-8. 2006
    To determine the efficacy and tolerability of phloroglucinol, an antispasmodic agent in the treatment of Irritable Bowel Syndrome (IBS).
  80. ncbi Hyperforin is a novel type of 5-lipoxygenase inhibitor with high efficacy in vivo
    Christian Feisst
    Institute of Pharmaceutical Chemistry, University of Frankfurt, Max von Laue Str 9, 60438 Frankfurt, Germany
    Cell Mol Life Sci 66:2759-71. 2009
    ..Together, hyperforin is a novel type of 5-LO inhibitor apparently acting by interference with the C2-like domain, with high effectiveness in vivo...
  81. ncbi Induction of multinucleation by beta-glucosyl Yariv reagent in regenerated cells from Marchantia polymorpha protoplasts and involvement of arabinogalactan proteins in cell plate formation
    Taeko Shibaya
    Department of Regulation Biology, Faculty of Science, Saitama University, Saitama, 338 8570, Japan
    Planta 230:581-8. 2009
    ..Our results indicated that AGPs might have an important role in cell plate formation, and perturbation of AGPs with betaglcY might result in remarkable multinucleation in protoplast-regenerated cells of M. polymorpha...
  82. ncbi Hypericum extract and hyperforin: memory-enhancing properties in rodents
    V Klusa
    Department of Pharmacology, Faculty of Medicine, University of Latvia, Riga
    Pharmacopsychiatry 34:S61-9. 2001
    ..Pure hyperforin seems to be a more potent antidementia agent than an antidepressant...
  83. ncbi Antiherbivore chemistry of Eucalyptus-cues and deterrents for marsupial folivores
    Ben D Moore
    School of Botany and Zoology, Australian National University, Canberra ACT 0200, Australia
    J Chem Ecol 30:1743-69. 2004
    Formylated phloroglucinol compounds (FPCs) are the single most important factor determining the amount of foliage that marsupial folivores eat from individual Eucalyptus trees...
  84. ncbi Induction of apoptosis in K562 cells by dicyclohexylammonium salt of hyperforin through a mitochondrial-related pathway
    Jin yun Liu
    School of Pharmaceutical Sciences, Sun Yat Sen University, Guangzhou 510006, PR China
    Chem Biol Interact 190:91-101. 2011
    Hyperforin is an abundant phloroglucinol-type constituent isolated from the extract of the flowering upper portion of the plant Hypericum perforatum L...
  85. ncbi Induced systemic resistance in Arabidopsis thaliana in response to root inoculation with Pseudomonas fluorescens CHA0
    Annalisa Iavicoli
    Departement de Biologie, Unité Biologie végétale, Universite de Fribourg, Ch du Musée 10, 1700 Fribourg, Switzerland
    Mol Plant Microbe Interact 16:851-8. 2003
    ....
  86. ncbi Determination of formaldehyde in foodstuffs by flow injection spectrophotometry using phloroglucinol as chromogenic agent
    Ziwei Li
    College of Chemistry and Chemical Engineering, Soochow University, District of Industrial Park, Suzhou, Jiangsu 215123, China
    Talanta 74:788-92. 2008
    A spectrophotometric method for the determination of formaldehyde in foodstuffs was described by using phloroglucinol as the chromogenic agent...
  87. ncbi Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)
    Feng Zhao
    Central Laboratories for Key Technology, Kirin Brewery Co, Ltd, Yokohama shi, Kanagawa 236 0004, Japan
    J Nat Prod 68:43-9. 2005
    ..The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined...
  88. ncbi Phloroglucinol compounds of natural origin
    Inder Pal Singh
    Department of Natural Products, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, SAS Nagar, Punjab 160062, India
    Nat Prod Rep 23:558-91. 2006
  89. ncbi Phloroglucinol diglycosides accompanying hydrolyzable tannins from Kunzea ambigua
    Naoki Kasajima
    School of Pharmacy, Shujitsu University, Nishigawara, Okayama 703 8516, Japan
    Phytochemistry 69:3080-6. 2008
    Six phloroglucinol diglucosides-kunzeaphlogins A-F (1-6) and a hydrolyzable tannin, kunzeatannin A (7)-were isolated along with 10 known polyphenols from the leaf extract of Kunzea ambigua...
  90. ncbi Hyperforin blocks neutrophil activation of matrix metalloproteinase-9, motility and recruitment, and restrains inflammation-triggered angiogenesis and lung fibrosis
    Raffaele Niero
    Department of Experimental Biomedical Sciences, Medical School, Padova, Italy
    J Pharmacol Exp Ther 321:492-500. 2007
    ..These results indicate that Hyp is a powerful anti-inflammatory compound with therapeutic potential, and they elucidate mechanistic keys...
  91. ncbi In vitro antimalarial activity of hyperforin, a prenylated acylphloroglucinol. A structure-activity study
    Luisella Verotta
    Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milan, Italy
    Bioorg Med Chem Lett 17:1544-8. 2007
    ..Related phloroglucinols like the hop beta-acids and the enantiomers of usnic acid showed only marginal activity, suggesting that hyperforin is a new antimalarial chemotype...
  92. ncbi Hyperforin and its analogues inhibit CYP3A4 enzyme activity
    Ju Young Lee
    Pharmaceutical Chemistry, Faculty of Pharmacy, University of Sydney, Building A15, Science Road, Sydney, NSW 2006, Australia
    Phytochemistry 67:2550-60. 2006
    ..63 microM) and furohyperforin (IC(50) 1.3 microM). As the acylphloroglucinols are potent inhibitors of the CYP3A4 enzyme, their modulation of the enzyme activity is unlikely to be involved in increased drug metabolism by St. John's wort...
  93. ncbi Evaluation of hyperforin analogues for inhibition of 5-lipoxygenase
    Christian Feisst
    Institute of Pharmaceutical Chemistry, University of Frankfurt, Marie Curie Str 9, D 60439 Frankfurt, Germany
    Med Chem 1:287-91. 2005
    ..Our data show that some of the oxidised hyperforin derivatives possess even improved efficacy, whereas alkylation and acylation have detrimental effects...
  94. ncbi Localization of an arabinogalactan protein epitope and the effects of Yariv phenylglycoside during zygotic embryo development of Arabidopsis thaliana
    Ying Hu
    Key Laboratory of the Ministry of Education for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, People s Republic of China
    Protoplasma 229:21-31. 2006
    ..The possible roles of AGPs in A. thaliana zygotic embryo development are also discussed...
  95. ncbi Structural investigations of isomeric oxidised forms of hyperforin by HPLC-NMR and HPLC-MSn
    J L Wolfender
    Institut de Pharmacognosie et Phytochimie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Phytochem Anal 14:290-7. 2003
    The prenylated phloroglucinol hyperforin, thought to be an essential component for the anti-depressant activity of St. John's Wort (Hypericum perforatum), is unstable...
  96. ncbi The antidepressant mechanism of Hypericum perforatum
    Tiziana Mennini
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, 20157, Milano, Italy
    Life Sci 75:1021-7. 2004
    ..In the rat, Hypericum extract might indirectly activate sigma receptors in vivo (through the formation of an unknown metabolite or production of an endogenous ligand), suggesting a new target for its antidepressant effects...
  97. ncbi Hypericum perforatum, a source of neuroactive lead structures
    Luisella Verotta
    Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, via Venezian 21, 20133 Milano, Italy
    Curr Top Med Chem 3:187-201. 2003
    ..One clinical trial carried out using two extracts with different hyperforin content indicate this constituent as (one of) the main active principle responsible for the antidepressant activity...
  98. ncbi Hyperforin inhibits cancer invasion and metastasis
    Massimo Dona
    Department of Experimental Biomedical Sciences, Medical School of Padova, Italy
    Cancer Res 64:6225-32. 2004
    ..These observations qualify Hyp-DCHA as an interesting lead compound to prevent and contrast cancer spread and metastatic growth...
  99. ncbi St John's wort: Prozac from the plant kingdom
    G Di Carlo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Trends Pharmacol Sci 22:292-7. 2001
    ..Biochemical and animal studies suggest that the phloroglucinol derivative hyperforin is the main active ingredient of St John's wort, and inhibits the synaptosomal uptake of ..
  100. ncbi Inhibition of lipopolysaccharide-induced pro-inflammatory cytokine expression via suppression of nuclear factor-kappaB activation by Mallotus japonicus phloroglucinol derivatives
    Rie Ishii
    Saitama Institute of Public Health, 639 1 Kamiokubo Saitama, Japan
    Biochim Biophys Acta 1620:108-18. 2003
    ..7, or human blood monocytes. Several phloroglucinol derivatives were isolated from the pericarps as active compounds...
  101. ncbi Modulation of chemoselectivity by protein additives. Remarkable effects in the oxidation of hyperforin
    Luisella Verotta
    Dipartimento di Chimica Organica e Industriale, via Venezian 21, 20133 Milano, Italy
    J Org Chem 69:7869-74. 2004
    ..Protein additives have a dramatic effect on the H(2)O(2) oxidation of hyperforin, either protecting the enolized phloroglucinol core from oxidation (human albumin) or promoting (HRP and ovalbumin) reaction pathways derived from the ..

Research Grants6

  1. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  2. CYROBIOLOGICAL PRESERVATION OF ANOPHELES EMBRYOS
    Peter Mazur; Fiscal Year: 2001
    ..The proposed chemical methods include phloroglucinol and low oxygen tensions to impede the phenoloxidase and peroxidase reactions...
  3. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  4. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  5. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  6. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..