Genomes and Genes
Summary: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
Publications404 found, 100 shown here
- Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesionsA L Cheng
Department of Internal Medicine, National Taiwan University College of Medicine, Taipei
Anticancer Res 21:2895-900. 2001b>Curcumin (diferuloylmethane), a yellow substance from the root of the plant Curcuma longa Linn., has been demonstrated to inhibit carcinogenesis of murine skin, stomach, intestine and liver...
- Curcumin as "Curecumin": from kitchen to clinicAjay Goel
Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States
Biochem Pharmacol 75:787-809. 2008..for inflammatory diseases and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, a yellow pigment present in turmeric (curry powder) has been shown to exhibit numerous ..
- Curcumin: from ancient medicine to current clinical trialsH Hatcher
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Cell Mol Life Sci 65:1631-52. 2008b>Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa)...
- Bioavailability of curcumin: problems and promisesPreetha Anand
Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Mol Pharm 4:807-18. 2007b>Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities...
- Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivoFusheng Yang
Department of Medicine, UCLA, Los Angeles, CA 90095, USA
J Biol Chem 280:5892-901. 2005..The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, ..
- Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathwayEduardo Molina-Jijón
Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, 04510 University City, DF, Mexico
Free Radic Biol Med 51:1543-57. 2011We report the role of mitochondria in the protective effects of curcumin, a well-known direct and indirect antioxidant, against the renal oxidant damage induced by the hexavalent chromium [Cr(VI)] compound potassium dichromate (K(2)Cr(2)O(..
- Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive elementElisabeth Balogun
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
Biochem J 371:887-95. 2003..Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a ..
- Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseasesBharat B Aggarwal
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Int J Biochem Cell Biol 41:40-59. 2009..This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ..
- Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteinsAjaikumar B Kunnumakkara
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Cancer Lett 269:199-225. 2008..b>Curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their ..
- The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouseG P Lim
Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
J Neurosci 21:8370-7. 2001..One alternative NSAID is curcumin, derived from the curry spice turmeric...
- Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcriptionKaranam Balasubramanyam
Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India
J Biol Chem 279:51163-71. 2004..In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding ..
- Anticancer potential of curcumin: preclinical and clinical studiesBharat B Aggarwal
Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX, USA
Anticancer Res 23:363-98. 2003b>Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer...
- Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetrationYin Meng Tsai
Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
Int J Pharm 416:331-8. 2011b>Curcumin has considerable neuro-protective and anti-cancer properties but is rapidly eliminated from the body...
- The targets of curcuminHongyu Zhou
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
Curr Drug Targets 12:332-47. 2011b>Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of the plant Curcuma longa...
- Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?Jayaraj Ravindran
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
AAPS J 11:495-510. 2009..Traditional medicines are generally free of the deleterious side effects and usually inexpensive. Curcumin, a component of turmeric (Curcuma longa), is one such agent that is safe, affordable, and efficacious...
- Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity modelsThimmaraju Rudrappa
Department of Plant and Soil Sciences, University of Delaware, Delaware Biotechnology Institute, Newark, DE 19711, USA
J Agric Food Chem 56:1955-62. 2008The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated...
- Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophagesAn Na Kim
Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Korea
Free Radic Biol Med 49:323-31. 2010..that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin. Treatment with BDMC suppressed inducible nitric oxide synthase expression and nitric oxide (NO) production by ..
- Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cellsMurali Mohan Yallapu
Cancer Biology Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
J Colloid Interface Sci 351:19-29. 2010b>Curcumin, a natural polyphenolic compound, has shown promising chemopreventive and chemotherapeutic activities in cancer...
- Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathwaysHiroshi Aoki
Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Mol Pharmacol 72:29-39. 2007..Here, we examined the anticancer efficacy and mechanisms of curcumin, a natural compound with low toxicity in normal cells, in U87-MG and U373-MG malignant glioma cells...
- Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDFShadan Ali
Division of Hematology Oncology, Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 70:3606-17. 2010b>Curcumin induces cancer cell growth arrest and apoptosis in vitro, but its poor bioavailability in vivo limits its antitumor efficacy...
- Curcumin and cancer: an "old-age" disease with an "age-old" solutionPreetha Anand
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Cancer Lett 267:133-64. 2008..the active principles in them and how do they mediate their effects against cancer is perhaps best illustrated by curcumin, a derivative of turmeric used for centuries to treat a wide variety of inflammatory conditions...
- Curcumin--from molecule to biological functionTuba Esatbeyoglu
Abteilung Lebensmittelwissenschaft, Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Deutschland
Angew Chem Int Ed Engl 51:5308-32. 2012..As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard)...
- Biological properties of curcumin-cellular and molecular mechanisms of actionB Joe
Department of Physiology and Molecular Medicine, Medical College of Ohio, Block Health Science Building, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
Crit Rev Food Sci Nutr 44:97-111. 2004..A vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcuminoid...
- Curcumin alleviates diabetic cardiomyopathy in experimental diabetic ratsWei Yu
Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
PLoS ONE 7:e52013. 2012..The present study was sought to investigate the effect of curcumin on modulating DCM and the mechanisms involved.
- Multiple biological activities of curcumin: a short reviewRadha K Maheshwari
Department of Pathology, Uniformed Services University of the Life Sciences, Center for Combat Casualty and Life Sustainment Research, Bethesda, Maryland 20814, USA
Life Sci 78:2081-7. 2006..These biological effects of turmeric have been attributed to its constituent curcumin that has been widely studied for its anti-inflammatory, anti-angiogenic, anti-oxidant, wound healing and anti-..
- Dose escalation of a curcuminoid formulationChristopher D Lao
Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, 2150 CCGC, Ann Arbor, MI 48109 0930, USA
BMC Complement Altern Med 6:10. 2006b>Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that has broad anticarcinogenic and cancer chemopreventive potential...
- Curcumin extract for prevention of type 2 diabetesSomlak Chuengsamarn
Division of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand
Diabetes Care 35:2121-7. 2012To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population.
- Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)Tauheed Ishrat
Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
Eur Neuropsychopharmacol 19:636-47. 2009Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors...
- Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cellsJie Yang
Department of Nephrology, Tangdu Hospital, and Department of Immunology, The Fourth Military Medical University, Xi an, Shaanxi Province, China
Med Oncol 27:1114-8. 2010The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases...
- Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathwaysShin Hwar Wu
Division of Critical Care Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan, ROC
Anticancer Res 30:2125-33. 2010It has been reported that curcumin inhibited various types of cancer cells in vitro and in vivo...
- Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcuminBalmiki Ray
Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA
Curr Opin Pharmacol 9:434-44. 2009..Turmeric is used as an anti-inflammatory medicine in various regions of Asia. Curcumin, which is a yellow colored polyphenol compound present in turmeric, showed anti-inflammatory properties...
- Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's diseaseAynun N Begum
Department of Medicine, University of California, Los Angeles, California, USA
J Pharmacol Exp Ther 326:196-208. 2008b>Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin (TC) may mediate efficacy...
- Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expressionBin Bao
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
Cancer Res 72:335-45. 2012..In this study, we probed EZH2 function in pancreatic cancer using diflourinated-curcumin (CDF), a novel analogue of the turmeric spice component curcumin that has antioxidant properties...
- Phase II trial of curcumin in patients with advanced pancreatic cancerNavneet Dhillon
Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
Clin Cancer Res 14:4491-9. 2008..We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor ..
- Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancerBin Bao
Department of Pathology, Wayne State University, Detroit, Michigan, United States of America
PLoS ONE 6:e17850. 2011....
- Curcumin protects retinal cells from light-and oxidant stress-induced cell deathMd Nawajes A Mandal
Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
Free Radic Biol Med 46:672-9. 2009..In search of effective therapeutic agents, we tested curcumin, a naturally occurring compound with known anti-inflammatory and antioxidative properties, in a rat model of ..
- Curcumin: the story so farR A Sharma
Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
Eur J Cancer 41:1955-68. 2005b>Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration...
- Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosisAlok C Bharti
Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Blood 101:1053-62. 2003..in human multiple myeloma (MM), we explored the possibility of using it as a target for MM treatment by using curcumin (diferuloylmethane), an agent known to have very little or no toxicity in humans...
- Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targetsBharat B Aggarwal
Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Trends Pharmacol Sci 30:85-94. 2009b>Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases...
- Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stressR Motterlini
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
Free Radic Biol Med 28:1303-12. 2000b>Curcumin, a widely used spice and coloring agent in food, has been shown to possess potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo...
- Therapeutic roles of curcumin: lessons learned from clinical trialsSubash C Gupta
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1901 East Road, Unit 1950, Houston, TX 77054, USA
AAPS J 15:195-218. 2013Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways...
- Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathwayVivian Soetikno
Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
Mol Nutr Food Res 57:1649-59. 2013We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney.
- Innovative preparation of curcumin for improved oral bioavailabilityHiroki Sasaki
Theravalues Corporation, Tokyo 102 0094, Japan
Biol Pharm Bull 34:660-5. 2011b>Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects...
- Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygenJe Moon Woo
Department of Ophthalmology, Ulsan University Hospital, Ulsan, Republic of Korea
Mol Vis 18:901-8. 2012To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.
- Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migrationDilek Coban
INRA, UMR 1019, UNH, CRNH Auvergne, Clermont Ferrand, France
Mol Nutr Food Res 56:1270-81. 2012The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level.
- Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcuminGuang Liang
School of Pharmacy, Wenzhou Medical College, College Town, Wenzhou, Zhejiang, China
J Cell Mol Med 13:3370-9. 2009b>Curcumin (diferuloylmethane) is an orange-yellow compound from turmeric (Curcuma longa), a spice found in curry powder...
- A potential role of the curry spice curcumin in Alzheimer's diseaseJohn M Ringman
University of California, Los Angeles, Department of Neurology, Alzheimer s Disease Research Center, Los Angeles, CA 90095, USA
Curr Alzheimer Res 2:131-6. 2005There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity...
- Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammationS S Ghosh
Department of Internal Medicine Nephrology, Sanger Hall, Rm 8 059, Virginia Commonwealth Univ, 1101 E Marshall St, Richmond, VA 23298, USA
Am J Physiol Renal Physiol 296:F1146-57. 2009..In hepatic cells, curcumin is shown to antagonize TNF-alpha-elicited NF-kappaB activation...
- Curcumin, a component of turmeric: from farm to pharmacySubash C Gupta
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
Biofactors 39:2-13. 2013b>Curcumin, an active polyphenol of the golden spice turmeric, is a highly pleiotropic molecule with the potential to modulate the biological activity of a number of signaling molecules...
- Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damageJing Han
State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology School of Basic Medical Sciences, Peking University, Beijing, China
Autophagy 8:812-25. 2012Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy...
- Curcumin activates human glutathione S-transferase P1 expression through antioxidant response elementToru Nishinaka
Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, 3 11 1 Nishikiori kita, Tondabayashi, Osaka 584 8540, Japan
Toxicol Lett 170:238-47. 2007b>Curcumin is a plant-derived diferuloylmethane compound extracted from Curcuma longa, possessing antioxidative and anticarcinogenic properties...
- Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's diseaseAnila Mathew
Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan
PLoS ONE 7:e32616. 2012..b>Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease...
- Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancerGouri Sankar Sen
Division of Molecular Medicine, Bose Institute, P 1 12, Calcutta Improvement Trust Scheme VII M, Kolkata 700054, India
J Biol Chem 286:42232-47. 2011..Interestingly, curcumin pretreatment of drug-resistant cells alleviated SMAR1-mediated p65NFκB activation and hence restored doxorubicin ..
- Curcumin: the Indian solid goldBharat B Aggarwal
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Adv Exp Med Biol 595:1-75. 2007..b>Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as ..
- Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitroKenjiro Ono
Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
J Neurosci Res 75:742-50. 2004..spectroscopic analysis with thioflavin T and electron microscopic studies, we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) ..
- Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030L Lin
Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205, USA
Br J Cancer 105:212-20. 2011..To date, whether STAT3 is activated and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, in colon cancer stem cells are still unknown.
- Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibitionStephen J McNally
Tissue Injury and Repair Group, University of Edinburgh, Chancellor s Building, Little France, Edinburgh EH16 4SB, UK
Int J Mol Med 19:165-72. 2007b>Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated...
- The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in ratsTatsuya Morimoto
Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
J Clin Invest 118:868-78. 2008..It has been previously shown that curcumin, a polyphenol responsible for the yellow color of the spice turmeric, possesses HAT inhibitory activity with ..
- Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay miceTozo Nishiyama
Functional Foods Development Division, and Life Science Research Laboratories, Life Science RD Center, Kaneka Corporation, Takasago, Hyogo 676 8688, Japan
J Agric Food Chem 53:959-63. 2005..Also, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone had PPAR-gamma ligand-binding activity...
- Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trialsAdeeb Shehzad
School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu, Korea
Arch Pharm (Weinheim) 343:489-99. 2010b>Curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used and highly researched phytochemicals...
- Biological activities of curcumin and its analogues (Congeners) made by man and Mother NaturePreetha Anand
Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Biochem Pharmacol 76:1590-611. 2008b>Curcumin, a yellow pigment present in the Indian spice turmeric (associated with curry powder), has been linked with suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and ..
- The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcuminD L French
Department of Radiology, McMaster University, Hamilton, Ontario, Canada
Phytomedicine 15:1069-78. 2008..of this study were to evaluate an animal model of postmenopausal osteoporosis and to search for evidence that curcumin reduces bone mineral losses in a dose-dependent manner when endogenous estrogen levels are reduced...
- Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathwayKyeongjin Kim
Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
FEBS Lett 584:707-12. 2010A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus...
- Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPKNathan M Weir
Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
Cancer Biol Ther 6:178-84. 2007b>Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells...
- Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studiesJenny Epstein
Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary, University of London, 4 Newark Street, London E1 2AT, UK
Br J Nutr 103:1545-57. 2010b>Curcumin is the active ingredient of turmeric. It is widely used as a kitchen spice and food colorant throughout India, Asia and the Western world...
- Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinomaReason Wilken
Department of Surgery, VA Greater Los Angeles Healthcare System, West Los Angeles, CA, USA
Mol Cancer 10:12. 2011b>Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric...
- Curcumin nanoformulations: a future nanomedicine for cancerMurali M Yallapu
Cancer Biology Research Center, Sanford Research University of South Dakota, 2301 E 60th Street North, Sioux Falls, SD 57104, USA
Drug Discov Today 17:71-80. 2012b>Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer ..
- Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancerSharanjot Saini
Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, USA
Cancer Prev Res (Phila) 4:1698-709. 2011..b>Curcumin (diferuloylmethane) is a natural compound that has been known to possess anticancer properties in various cancers,..
- Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivoPreetha Anand
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
Biochem Pharmacol 79:330-8. 2010b>Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with antioxidant, anti-inflammatory, antiproliferative, anticancer, antidiabetic, antirheumatic, and antiviral effects, but its optimum potential is ..
- Curcumin-mediated lifespan extension in Caenorhabditis elegansVivian Hsiu Chuan Liao
Department of Bioenvironmental Systems Engineering, National Taiwan University, No 1 Roosevelt Road, Sec 4, Taipei 106, Taiwan
Mech Ageing Dev 132:480-7. 2011b>Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities...
- Phase I clinical trial of oral curcumin: biomarkers of systemic activity and complianceRicky A Sharma
Oncology Department, University of Leicester, Leicester, United Kingdom
Clin Cancer Res 10:6847-54. 2004b>Curcumin, a polyphenolic antioxidant derived from a dietary spice, exhibits anticancer activity in rodents and in humans...
- Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemiaChenhui Yang
Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Brain Res 1282:133-41. 2009..b>Curcumin is proved to elicit a vanity of biological effects through its antioxidant and anti-inflammatory properties...
- Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogasterKyu Sun Lee
Aging Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea
Rejuvenation Res 13:561-70. 2010b>Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia...
- Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseasesStig Bengmark
Institute of Hepatology, University College, London Medical School, London, United Kingdom
JPEN J Parenter Enteral Nutr 30:45-51. 2006..Drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest...
- Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cellsMichael Sun
Department of Investigational Cancer Therapeutics Phase I Program, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Mol Cancer Ther 7:464-73. 2008..With its low toxicity profile, curcumin (diferuloylmethane), a naturally occurring flavinoid derived from the rhizome of Curcuma longa, has great promise...
- Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulationIndira Jutooru
Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
J Biol Chem 285:25332-44. 2010b>Curcumin activates diverse anticancer activities that lead to inhibition of cancer cell and tumor growth, induction of apoptosis, and antiangiogenic responses. In this study, we observed that curcumin inhibits Panc28 and L3...
- Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organsAjay Goel
Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA
Nutr Cancer 62:919-30. 2010b>Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and ..
- Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene productsAjaikumar B Kunnumakkara
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
Cancer Res 67:3853-61. 2007..b>Curcumin, a component of turmeric (Curcuma longa), is one such agent that has been shown to suppress the transcription ..
- Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampusSo Jung Kim
Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, Korea
J Biol Chem 283:14497-505. 2008b>Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation...
- Curcumin inhibits melanogenesis in human melanocytesCai Xia Tu
Department of Dermatology, 2nd Affiliated Hospital of Dalian Medical University, Liaoning 116027, PR China
Phytother Res 26:174-9. 2012..b>Curcumin is a plant-derived polyphenol, which has been reported to suppress melanogenesis in B16 melanoma cells...
- Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complicationsBo Meng
Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical College, 325027, Wenzhou, Zhejiang Province, China
Curr Pharm Des 19:2101-13. 2013..b>Curcumin, a phytochemical found in the spice turmeric, has been used in India for centuries, and it has no known side ..
- Curcumin induces cell death in esophageal cancer cells through modulating Notch signalingDharmalingam Subramaniam
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
PLoS ONE 7:e30590. 2012b>Curcumin inhibits the growth of esophageal cancer cell lines; however, the mechanism of action is not well understood...
- Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independentVineshkumar T Puliyappadamba
Integrated Cancer Research Program, Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
Mol Cancer 9:220. 2010....
- Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasiaRobert E Carroll
Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Cancer Prev Res (Phila) 4:354-64. 2011b>Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and adenomas in murine models of colorectal carcinogenesis...
- Discovery of curcumin, a component of golden spice, and its miraculous biological activitiesSubash C Gupta
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Clin Exp Pharmacol Physiol 39:283-99. 20121. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years...
- Curcumin is a potent modulator of microglial gene expression and migrationMarcus Karlstetter
Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
J Neuroinflammation 8:125. 2011..b>Curcumin, a major component of tumeric, alleviates pro-inflammatory activities of these cells by inhibiting nuclear factor ..
- Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in ratsKuntal Maiti
School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India
Int J Pharm 330:155-63. 2007A novel formulation of curcumin in combination with the phospholipids was developed to overcome the limitation of absorption and to investigate the protective effect of curcumin-phospholipid complex on carbon tetrachloride induced acute ..
- Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cellsRatul Kumar Das
Department of Biotechnology, Indian Institute of Technology Guwahati, Assam, India
Nanomedicine 6:153-60. 2010We report a nanoformulation of curcumin with a tripolymeric composite for delivery to cancer cells...
- Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed ratsYing Xu
Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA
Brain Res 1162:9-18. 2007..As the active component of curcuma longa, curcumin possesses many therapeutic properties; we have previously described its antidepressant activity in our earlier ..
- The effect of curcumin on insulin release in rat-isolated pancreatic isletsMohamed T Abdel Aziz
Department of Medical Biochemistry, Cairo University, Egypt
Angiology 61:557-66. 2010b>Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-1...
- Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alphaMaya Mouler Rechtman
The Institute of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
FEBS Lett 584:2485-90. 2010..Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication...
- Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitisLaura Camacho-Barquero
Department of Pharmacology, School of Pharmacy, University of Seville, Profesor García González Street, 2, 41012 Seville, Spain
Int Immunopharmacol 7:333-42. 2007..b>Curcumin is a polyphenol derived from Curcuma longa, which is known to have anti-inflammatory activity...
- Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatmentPurusotam Basnet
Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø N 9037, Norway
Molecules 16:4567-98. 2011..be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, ..
- Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathwayConstanze Buhrmann
Institute of Anatomy, Ludwig Maximilian University Munich, 80336 Munich, Germany
J Biol Chem 286:28556-66. 2011..Recent studies in various cell models have demonstrated that curcumin targets the NF-κB signaling pathway...
- Protective effect of curcumin against lead neurotoxicity in ratPradeep K Shukla
Industrial Toxicology Research Centre, PO Box 80, MG Marg, Lucknow 226001, India
Hum Exp Toxicol 22:653-8. 2003b>Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases...
- Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rateBasir Ahmad
Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824, USA
J Biol Chem 287:9193-9. 2012..In this work, we examined the ability of curcumin, a compound found in turmeric, to prevent aggregation of the protein...
- Intracellular ROS protection efficiency and free radical-scavenging activity of curcuminAbolfazl Barzegar
Research Institute for Fundamental Sciences RIFS, University of Tabriz, Tabriz, Iran
PLoS ONE 6:e26012. 2011b>Curcumin has many pharmaceutical applications, many of which arise from its potent antioxidant properties...
- Biological effects of curcumin and its role in cancer chemoprevention and therapySarvjeet Singh
Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
Anticancer Agents Med Chem 6:259-70. 2006b>Curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents...
- Multitargeting by curcumin as revealed by molecular interaction studiesSubash C Gupta
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
Nat Prod Rep 28:1937-55. 2011b>Curcumin (diferuloylmethane), the active ingredient in turmeric (Curcuma longa), is a highly pleiotropic molecule with anti-inflammatory, anti-oxidant, chemopreventive, chemosensitization, and radiosensitization activities...
- Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stabilityHanne Hjorth Tønnesen
Institute of Pharmacy, University of Oslo, P O Box 1068 Blindern, 0316 Oslo, Norway
Int J Pharm 244:127-35. 2002Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound...
- Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancerDandekar Prajakta
Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N P Marg, Matunga, Mumbai 400019, India
J Biomed Nanotechnol 5:445-55. 2009The investigation was aimed at designing pH-sensitive, polymeric nanoparticles of curcumin, a natural anti-cancer agent, for the treatment of colon cancer...
- Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductaseSTEPHEN WILLIAM TUTTLE; Fiscal Year: 2010..b>Curcumin is a naturally occurring plant polyphenolic antioxidant with potent chemopreventive and antintumorigenic ..
- Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for CerebrLEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012..hemopexin, protoporphyrin IX and mesoporphyrin IX), inducing hemeoxygenase-1 (HO-1: hyperbaric oxygen, curcumin, furan-2-yl-3-pyridin-2-yl-propenone, -deoxy-delta 12,14-prostaglandin J2) or providing anti-oxidant protection ..
- Memory and Mood Enhancing Therapies for Gulf War IllnessAshok K Shetty; Fiscal Year: 2013..test the hypothesis that combined applications of an anti-depressant drug (FLU or ROL) and an antioxidant drug (Curcumin [CUR] or Resveratrol [RESV];dietary supplements having anti-oxidant, anti-inflammatory, and neurogenesis ..
- MECHANICAL STIMULATION OF IVD CELLSLori A Setton; Fiscal Year: 2013..novel ELP-based depots to provide for sustained release of a safe, small molecule inhibitor of inflammation - curcumin. We propose that an injectable, in situ forming curcumin drug depot will provide for rapid reversal of symptoms ..
- Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements asZhongfa Liu; Fiscal Year: 2010..of both global and specific promoter DNA methylation levels established on our group, parthenolide and curcumin have been found to possess DNA hypomethylation activity...
- Antioxidants and Antiinflammatory in Colorectal CancerAh Ng Tony Kong; Fiscal Year: 2012..sulforaphane (SFN) and phenethyl isothiocyanate (PEITC)] and the anti-inflammatory [the beta diketones, curcumin (CUR) and dibenzoylmethane (DBM)] effects, alone or in combination against colorectal cancer...
- Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesisRupesh Chaturvedi; Fiscal Year: 2013..This application will facilitate understanding f the molecular mechanisms underlying the action of curcumin in protecting the host from H. pylori infection and associated pathology. H...
- Clinical Translation of Curcumin Therapy to Treat Arterial AgingDouglas R Seals; Fiscal Year: 2013..b>Curcumin is a naturally occurring polyphenol found in the Indian spice turmeric that improves physiological function in ..
- Epigenetic modifications by dietary PEITC in prostate cancerAh Ng Tony Kong; Fiscal Year: 2013..During the previous funding period, we have found that phenethyl isothiocyanate (PEITC) and curcumin (CUR) alone and in combination inhibit the development and progression of PCa in nude mice PC-3 xenograft and ..
- Broadly Neuroprotective Drug for TBIFernando Gomez Pinilla; Fiscal Year: 2010..identification and validation of sensitive and predictive biomarkers to evaluate status of a specific nutrient (curcumin derivative)...
- Pharmacokinetics and Metabolism of Oxidized CurcuminClaus Schneider; Fiscal Year: 2013DESCRIPTION (provided by applicant): Curcumin, a polyphenol isolated from the plant turmeric, is recognized for its anti-inflammatory and anti- tumorigenic bioactivities...
- Chemoprotective effects of natural products on colonic adult stem cellsBhimanagouda S Patil; Fiscal Year: 2013DESCRIPTION (provided by applicant): We have demonstrated that chemoprotective diets containing turmeric (curcumin) and citrus (limonin) bioactives reduce chronic inflammation and colon cancer risk...
- Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma andMAMORU NONE SHOJI; Fiscal Year: 2012..The cytotoxic agent we have developed is EF24, a synthetic curcumin analog, which will be linked to enzymatically inactive coagulation factor VIIa (fVIIa), the high affinity ligand ..
- Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 InteractionLongqin Hu; Fiscal Year: 2010..Keap1-Nrf2 interaction plays a key role in cancer chemoprevention by many chemicals like sulforaphane, curcumin, and epigallocatechin gallate derived from natural sources such as fruits, vegetables, and tea products...
- Intestinal Barrier Function: Protective Effects of CurcuminPawel R Kiela; Fiscal Year: 2013..In this proposal, we hypothesize that curcumin improves intestinal barrier through inhibition of IFN-? signaling in the CEC, inhibition of neutrophil ..
- Mechanisms of Mitochondrial Dysfunction in Brain VasculatureNeetu Tyagi; Fiscal Year: 2013..Interestingly, THC decreases Hcy level and mitigates brain damage. Tetra hydro-curcumin (THC), a major herbal antioxidant and anti-inflammatory agent, has shown to protect brain against I/R injury...
- Apoptosis pathways underlying adipogenesisNiketa A Patel; Fiscal Year: 2013..PKC4II, a serine/threonine protein kinase promotes cell survival. Natural compounds such as resveratrol and curcumin exhibit anti-adipogenic activities and promote apoptosis in adipocytes...
- Phytochemicals &Metabolism in Pancreatic Diseases/Pandol, StephenVay Liang W Go; Fiscal Year: 2011..The experiments in this project are designed to test the effect of each of rottlerin, ellagic acid, embelin, curcumin and lycopene on regulating the proliferative metabolic phenotype of the pancreatic stellate and cancer cells;and ..
- Polyphenolic Interventions for tau Pathogenesis in Alzheimers ModelsSALLY ANN FRAUTSCHY; Fiscal Year: 2013..Recent data from our lab and others implicate soluble tau oligomers. Our data show that curcumin selectively reduces soluble tau dimers, and transgene dependent defects in heat shock proteins (HSPs), behavior, ..
- Curcuma Longa: epigenetic effects in prostate and colon cancerAh Ng Tony Kong; Fiscal Year: 2013..L.), usually contain three major components, curcumin (CUR;~77%), demethoxycurcumin (~17%) and bis-demethoxycurcumin (~3%), they are commonly used as botanical dietary ..
- Imaging NFkB Activity in Relation to Animal Behavior in Peripheral NeuropathyROBERT D BOWLES; Fiscal Year: 2013..In Aim 2, the therapeutic efficacy of curcumin as an NF-kB inhibitor will be evaluated following CCI via noninvasive, in vivo imaging and markers of function ..
- Chemosensitization of Pancreatic Cancer Cells by Curcumin and Vitamin D ReceptorTIMOTHY YEN; Fiscal Year: 2013..This proposal seeks to extend the recent finding that the natural compound curcumin is a ligand for VDR...
- Identification and therapeutic application of miRNA-drivers in lung cancerANDREA LYNN KASINSKI; Fiscal Year: 2013..Kasinski utilized biochemical assays to identified IKK-[unreadable] as a direct target of EF24, an analogue of curcumin that ultimately made its way into clinical trials...
- Curcumin chemoprevention in familial adenomatous polyposisFrancis M Giardiello; Fiscal Year: 2013..b>Curcumin is the major yellow pigment extracted from turmeric the powdered root of the herb Curcuma longa...
- Curcumin and Quercetin in Colon Cancer: Role of Macrophage-Induced InflammationELIZABETH ANGELA MURPHY; Fiscal Year: 2010..The consumption of the anti- inflammatory dietary constituents curcumin, which is a component of the Indian spice currie, and quercetin, a flavonoid present in various fruits and ..
- Lupus Association with Signal Transducer and Activator of Transcription 4JOHN BARKER HARLEY; Fiscal Year: 2013..Initially, we will explore the potential impact on STAT4 activity with the known inhibitors (lisopfylline, curcumin, and statins)...
- Synthesis and Characterization of Polymeric Antioxidant microparticles for the prNIHAR MANILAL SHAH; Fiscal Year: 2013..A potent antioxidant, such as curcumin, may represent an exciting therapeutic agent in OM prevention as a direct inhibitor of the earliest phase of OM ..
- Silk Fibroin Small-Molecule Drug Carriers for the Treatment of OsteoarthritisTIMOTHY KARIITHI MWANGI; Fiscal Year: 2013..b>Curcumin is a small di-phenol that inhibits inflammation in many cell types and will be used as a model drug here...
- Curcumin inhbits BPDE-induced damage by lowering the threshold of p53 activationERICA NICOLE ROGERS; Fiscal Year: 2011..While dietary components such as curcumin (turmic spice) show promising effects against BPDEinduced carinogenesis, its exact mode of action is not fully ..
- Diet and Exercise (DE) Program for Alzheimer PreventionSALLY ANN FRAUTSCHY; Fiscal Year: 2010..Our data suggest that the omega-3 fatty acid docosahexaenoic acid (DHA) and the phenolic antioxidant curcumin (from turmeric) synergize to reduce AD pathogenesis in both APP/ A[unreadable] and tau pathology models...
- Assessment of Biomarkers and Behavior in a Transgenic Rat Model of ADEDMOND HUATUNG TENG; Fiscal Year: 2013..We further hypothesize that these changes will be differentially modulated by treatment with curcumin or docosahexaenoic acid (DMA) and will be affected by both the duration of treatment and the severity of disease ..
- Restoration of Homeostasis After Brain TraumaFernando Gomez-Pinilla; Fiscal Year: 2013..In turn, the curry spice curcumin, traditionally known in Asia for its medicinal power, has been shown in our hands to promote energy homeostasis ..
- Targeting both intrinsic and extrinsic apoptosis by FLLL-12 in lung cancerA R M Ruhul Amin; Fiscal Year: 2013..Extensive preclinical research over the last several decades has demonstrated that curcumin has strong potential for chemoprevention, which brought this agent into clinical trials...
- Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's DiseaseGregory M Cole; Fiscal Year: 2013..Aim 2) Determine if limited DHA efficacy (especially with ApoE4 carriers) is improved with lipoate, curcumin or the combination, Aim 3) Identify ApoE isoform-dependent plasma biomarkers that our data suggest reflect ..
- Development of a Melanoma Chemoprevention ModelChristopher D Lao; Fiscal Year: 2010..can be used to test putative Chemoprevention agents by modulating important molecular events and that topical curcumin can delay or prevent transformation and progression of melanocytes in humans at least in part by its modulating ..
- Amyloid-Lowering Small Molecule AB-Binding Agents in ADWilliam E Klunk; Fiscal Year: 2010..agents are third and fourth generation Congo red derivatives that structurally resemble the natural product, curcumin. As part of a program to develop in vivo amyloid imaging agents, these compounds were designed to have high ..
- Colorectal cancer chemoprevention with phytochemical combinationsSwati Nagar; Fiscal Year: 2013..Phytochemical combinations trans-resveratrol + curcumin and trans-resveratrol + chrysin in ratios based on individual antiproliferative IC50s will be tested and compared ..
- Oxidative Metabolites of Curcumin and their Biological ActivityODAINE GORDON; Fiscal Year: 2013DESCRIPTION (provided by applicant): Curcumin, the polyphenolic yellow pigment from the turmeric plant, exhibits anti-inflammatory, antioxidant, and anticancer effects in vitro and in animal models...
- Curcumin to Augment Neonatal Lung Injury/RepairReiko Sakurai; Fiscal Year: 2012..b>Curcumin [1,7-bis (4'-hydroxy-3'-methoxyphenyl)-1,6-heptadiene-3,5-dione], a naturally occurring pigment derived ..
- A noninvasive optical imaging of retinal amyloid beta deposits in AD patientsMaya Koronyo-Hamaoui; Fiscal Year: 2013..Further development of a novel noninvasive retinal imaging approach by our team to detect these plaques by curcumin labeling in live AD transgenic mouse models, allowed for the in vivo imaging of Abeta plaques at unprecedented ..
- Development of a novel NF-kB antagonist to block cytokine-induced behavioral chanTHADDEUS W PACE; Fiscal Year: 2010..the efficacy of UBS109, a water soluble nuclear factor kappa B (NF-kB ) antagonist structurally related to curcumin, the principal curcuminoid of the Indian curry spice turmeric, to block CNS and behavioral changes in an animal ..
- AnnexinA2/progastrin and stem cells: dietary cancer preventionPomila Singh; Fiscal Year: 2013..Our preliminary studies suggest that curcumin significantly reduces expression of ANXA2 and stem cell markers;intriguingly opposite effects of curcumin were ..
- Identification of Natural Product Inhibitors of Breast Cancer Bone MetastasisJanet L Funk; Fiscal Year: 2012..consumption is of interest given existing scientific evidence that one particular chemical found in turmeric, curcumin, can prevent cancer cell growth...
- Radiation injury to the heartJohn E Baker; Fiscal Year: 2010..Furthermore, the pharmaceutical Losartan and the nutriceutical curcumin appear to prevent TBI-induced development of risk factors for cardiovascular disease...
- Differentiation and Elimination of Chemo-surviving Colon TumorsADHIP N MAJUMDAR; Fiscal Year: 2013..renders the FUOX-resistant colon cancer cells susceptible not only to FUOX but also to 3, 4-difluorobenzo-curcumin or difluorinated curcumin (CDF) and the combination of CDF and FUOX...
- APC mutation and breast cancer: Prevention by curcuminMeena Katdare; Fiscal Year: 2010..We have shown that the altered molecular markers for tumorigenicity can be prevented by dietary agent, Curcumin, the yellow curry powder extensively used in Asian countries...
- Prevention of Tumor Progression by a Novel ApproachFazlul H Sarkar; Fiscal Year: 2013..To that end, we have published, for the first time, that a synthetic analog of a non-toxic natural agent curcumin, named CDF is superior in its target tissue (pancreas) bioavailability without any adverse side effects, and the ..
- Anti-Promoting Effects of Triterpenes Alone or Combined with Other PhytochemicalsThomas J Slaga; Fiscal Year: 2013..frutescens) when combined with other phytochemicals such as Res, curcumin (Curc), 6-shogaol (6Sho) or Rapa will produce either additive or possibly synergistic chemopreventive effects...
- Imaging AD Amyloidosis Pathology by Novel Multi-modal NIR/PET/19F MRI ProbesChongzhao Ran; Fiscal Year: 2013..b>Curcumin, the principal curcuminoid of the Indian curry, has been used for ex vivo detection of amyloid deposits...
- The Role of Aryl Hydrocarbon Receptor in Colon TumorigenesisGREGORY DEAN KENNEDY; Fiscal Year: 2013..chemoprotective agents includes naturally occurring dietary compounds such as indole-3- carbinol, chrysin and curcumin, as well as therapeutic agents like Sulindac and other NSAIDs...
- Pancreatic Cancer Therapy with GRP Receptor-Targeted Imageable Diphenyl difluorokVibhudutta Awasthi; Fiscal Year: 2010..We are developing a series of curcumin-based antiproliferative drugs including a diphenyl difluoroketone (DPDK) compound...
- The effect of curcumin on age-related cognitive decline in the rhesus monkeyMARK BARRY MOSS; Fiscal Year: 2013..Toward this evolving hypothesis, Curcumin, a natural phenol and member of the ginger family, has been shown to evidence such positive effects and provide a ..
- Inflammatory Mediators of Prostate Cancer Metastasis and Responses to CurcuminMagaly Martinez-Ferrer; Fiscal Year: 2013..that predict biochemical recurrence of prostate cancer regulate metastatic progression of the cancer and curcumin can inhibit metastasis of prostate cancer...
- Oxidative activation of the dietary cancer chemopreventive agent curcuminClaus Schneider; Fiscal Year: 2013DESCRIPTION (provided by applicant): Curcumin, a polyphenol isolated from the plant turmeric, is recognized for its antioxidant, anti-inflammatory and anti-tumorigenic bioactivities...
- Effects of UBS109, a novel NF-kappaBeta inhibitor, on depressive-like behaviorsANLYS OLIVERA; Fiscal Year: 2010..Work in the sponsor's laboratory is focused on the development of anologues of curcumin, a component of the Indian spice, turmeric, which improve upon curcumin's anti-NF-kB activity as well as its ..
- Curcuma longa L. in Rheumatoid Arthritis (CLaRA): Clinical Planning StudyJanet L Funk; Fiscal Year: 2013..NCCAM has identified as a high priority research area the evaluation of various formulations of turmeric/curcumin for the treatment of musculoskeletal pain, including comparisons of bioavailability and pharmacokinetic ..
- Curcumin: A Multi-Mechanism HIV MicrobicideRaju C Reddy; Fiscal Year: 2009..Among the compounds being investigated for this purpose, the turmeric- derived polyphenol curcumin is particularly promising because it inhibits HIV replication by several mechanisms...
- Curcumin and Piperine in Breast Cancer PreventionMadhuri Kakarala; Fiscal Year: 2011..b>Curcumin, a potent cancer preventive polyphenol, prevents cellular carcinogenesis progression via a diverse set of ..
- Mechanism of inhibition of APP processing and amyloid formationSTEVEN OWEN SMITH; Fiscal Year: 2013..The small molecule inhibitors include the natural products, curcumin and resveratrol. The peptide inhibitors are designed on the basis of the structure of the A? fibrils...
- AYURVEDIC ALTERNATIVES IN AUTOIMMUNITYChandra Mohan; Fiscal Year: 2010..Based on its efficacy in several other chronic diseases, the Ayurvedic supplement, curcumin holds great promise in lupus treatment - however, this has never been tested directly...
- Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiationHuang Ge Zhang; Fiscal Year: 2010DESCRIPTION (provided by applicant): The naturally occurring polyphenol, curcumin, has been shown to be a potent chemotherapeutic agent in a variety of tumor models;however, its effects on tumor-associated immunosuppression have not been ..
- Synergistic anticancer effects of docosahexanoic acid and curcuminRAFAT ALI SIDDIQUI; Fiscal Year: 2010..we propose to investigate the synergistic effects of two dietary components: docosahexaenoic acid (DHA) and curcumin (CCM)...
- NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISMARION CHAN; Fiscal Year: 2004..However, one of the major active principles in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions...
- URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPYRama Ramanujam; Fiscal Year: 2006..CAM agents, such as curcumin, are known to inhibit I-kappaB phosphorylation, thereby inhibiting NFkappaB activation and suppressing ..
- Curcumin/Bioperine in Multiple MyelomaSaroj Vadhan Raj; Fiscal Year: 2005Extensive research over the past 5 decades has suggested the therapeutic potential of curcumin (diferuloylmethane), a polyphenol derived from the plant Curcuma Ionga, in the prevention and treatment of cancer based on its in vitro and in ..
- Novel Antioxidants for Treatment of Diabetic RetinopathyDanyang Chen; Fiscal Year: 2009..b>Curcumin, a polyphenolic compound derived from dietary spice turmeric, has a wide range of pharmacologic effects, ..
- NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESISMARION CHAN; Fiscal Year: 2000..However, one of the major active principles in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions...
- Targeting Egr-1 with Curcumin Analogs for Prostate Cancer PreventionMarco Bisoffi; Fiscal Year: 2009Targeting Egr-1 with Curcumin Analogs for Prostate Cancer Prevention Bisoffi, Marco Project Summary The problem addressed in this proposal: Field cancerization, i.e...
- Mechanistic Studies on the Disposition of Farnesol with Single and Multiple DosinThomas Cook; Fiscal Year: 2007..Many cancer prevention agents isolated from foods have wide safety margins such as curcumin, sulforaphane, and perillyl alcohol...
- MECHANISMS FOR CHEMOPREVENTION OF COLON CANCERCHINTHALAPALLY RAO; Fiscal Year: 2004..the proposal is to elucidate the inhibitory mechanisms in colon carcinogenesis by the naturally occurring agents curcumin and phenylethyl-3-methylcaffeate (PEMC). Colon cancer is the second most common malignancy in the Western world...
- DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERSSTEVEN SHIFF; Fiscal Year: 1999..ingredients contained within these foods are likely abundant, the plant-derived phenolic compounds such as curcumin, rutin, and quercetin, are particularly compelling compounds to study...
- INHIBITION OF PROGESTIN-DEPENDENT ANGIOGENESIS IN BREAST CANCERCANDACE CARROLL; Fiscal Year: 2009..There is growing evidence that the Indian spice, curcumin, and the estrogen metabolite 2-methoxyestradiol (2-ME2), function as anti-angiogenic and anti-cancer compounds in ..
- Cell-type specific targting of curcuminBIDDANDA PONNAPPA; Fiscal Year: 2005..One such dietary ingredient is curcumin, which constitutes the yellow pigment of turmeric, the spice that gives yellow color to curry...
- Targeting of Curcumin-genistein nanocomplexes for Treatment of Prostate CancerSubhra Mohapatra; Fiscal Year: 2009..goal of this proposal is to design novel treatments for prostate cancer (PCa) that employ specific targeting of curcumin and genistein nanocomplexes to PCa cells...
- New Approaches to Prevent or Treat Breast Cancer MetastasesClaudia Gravekamp; Fiscal Year: 2009..improvement of vaccine therapy against metastatic breast cancer by combining vaccination with the IL-6 inhibitor curcumin, using the preclinical metastatic mouse breast tumor model 4T1...
- Chronobiological Principles to Maximize Efficacy of Alt*Jack Burton; Fiscal Year: 2004..evaluate chronotherapy (AIM #1) of three structurally and mechanistically distinct dietary agents, vitamin D3, curcumin and selenium (in the sodium selenite form) that have undergone preclinical and clinical trials alone or as ..
- PLANT ANTITUMOR AGENTSKuo Hsiung Lee; Fiscal Year: 2009..g., neotanshinlactone and analogs, new active constituents of Quassia gabonensis), prostate cancer actives (new curcumin analogs), and differentiation/apoptosis inducers (new water-soluble dithiophene derivatives)...