curcumin

Summary

Summary: A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.

Top Publications

  1. ncbi Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    A L Cheng
    Department of Internal Medicine, National Taiwan University College of Medicine, Taipei
    Anticancer Res 21:2895-900. 2001
  2. ncbi Curcumin as "Curecumin": from kitchen to clinic
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States
    Biochem Pharmacol 75:787-809. 2008
  3. ncbi Curcumin: from ancient medicine to current clinical trials
    H Hatcher
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cell Mol Life Sci 65:1631-52. 2008
  4. ncbi Bioavailability of curcumin: problems and promises
    Preetha Anand
    Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharm 4:807-18. 2007
  5. ncbi Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    Fusheng Yang
    Department of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 280:5892-901. 2005
  6. ncbi Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathway
    Eduardo Molina-Jijón
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, 04510 University City, DF, Mexico
    Free Radic Biol Med 51:1543-57. 2011
  7. pmc Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    Elisabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 371:887-95. 2003
  8. pmc Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Biochem Cell Biol 41:40-59. 2009
  9. ncbi Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 269:199-225. 2008
  10. ncbi The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    G P Lim
    Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 21:8370-7. 2001

Detail Information

Publications404 found, 100 shown here

  1. ncbi Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions
    A L Cheng
    Department of Internal Medicine, National Taiwan University College of Medicine, Taipei
    Anticancer Res 21:2895-900. 2001
    b>Curcumin (diferuloylmethane), a yellow substance from the root of the plant Curcuma longa Linn., has been demonstrated to inhibit carcinogenesis of murine skin, stomach, intestine and liver...
  2. ncbi Curcumin as "Curecumin": from kitchen to clinic
    Ajay Goel
    Gastrointestinal Cancer Research Laboratory, Department of Internal Medicine, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, TX, United States
    Biochem Pharmacol 75:787-809. 2008
    ..for inflammatory diseases and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, a yellow pigment present in turmeric (curry powder) has been shown to exhibit numerous ..
  3. ncbi Curcumin: from ancient medicine to current clinical trials
    H Hatcher
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cell Mol Life Sci 65:1631-52. 2008
    b>Curcumin is the active ingredient in the traditional herbal remedy and dietary spice turmeric (Curcuma longa)...
  4. ncbi Bioavailability of curcumin: problems and promises
    Preetha Anand
    Cytokine Research Laboratory and Pharmaceutical Development Center, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Pharm 4:807-18. 2007
    b>Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities...
  5. ncbi Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo
    Fusheng Yang
    Department of Medicine, UCLA, Los Angeles, CA 90095, USA
    J Biol Chem 280:5892-901. 2005
    ..The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, ..
  6. ncbi Curcumin prevents Cr(VI)-induced renal oxidant damage by a mitochondrial pathway
    Eduardo Molina-Jijón
    Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, 04510 University City, DF, Mexico
    Free Radic Biol Med 51:1543-57. 2011
    We report the role of mitochondria in the protective effects of curcumin, a well-known direct and indirect antioxidant, against the renal oxidant damage induced by the hexavalent chromium [Cr(VI)] compound potassium dichromate (K(2)Cr(2)O(..
  7. pmc Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
    Elisabeth Balogun
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Biochem J 371:887-95. 2003
    ..Recently, the natural antioxidants curcumin and caffeic acid phenethyl ester (CAPE) have been identified as potent inducers of haem oxygenase-1 (HO-1), a ..
  8. pmc Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Int J Biochem Cell Biol 41:40-59. 2009
    ..This is not the case, however, with curcumin, a yellow-pigment substance and component of turmeric (Curcuma longa), which was identified more than a century ..
  9. ncbi Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    Ajaikumar B Kunnumakkara
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Lett 269:199-225. 2008
    ..b>Curcumin, a yellow coloring agent in turmeric, has been shown to interact with a wide variety of proteins and modify their ..
  10. ncbi The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    G P Lim
    Departments of Medicine and Neurology, University of California, Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 21:8370-7. 2001
    ..One alternative NSAID is curcumin, derived from the curry spice turmeric...
  11. ncbi Curcumin, a novel p300/CREB-binding protein-specific inhibitor of acetyltransferase, represses the acetylation of histone/nonhistone proteins and histone acetyltransferase-dependent chromatin transcription
    Karanam Balasubramanyam
    Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore, 560064, India
    J Biol Chem 279:51163-71. 2004
    ..In this study, we report that curcumin (diferuloylmethane), a major curcumanoid in the spice turmeric, is a specific inhibitor of the p300/CREB-binding ..
  12. ncbi Anticancer potential of curcumin: preclinical and clinical studies
    Bharat B Aggarwal
    Cytokine Research Section, Department of Bioimmunotherapy, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX, USA
    Anticancer Res 23:363-98. 2003
    b>Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent and treat cancer...
  13. ncbi Curcumin and its nano-formulation: the kinetics of tissue distribution and blood-brain barrier penetration
    Yin Meng Tsai
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Int J Pharm 416:331-8. 2011
    b>Curcumin has considerable neuro-protective and anti-cancer properties but is rapidly eliminated from the body...
  14. pmc The targets of curcumin
    Hongyu Zhou
    Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130 3932, USA
    Curr Drug Targets 12:332-47. 2011
    b>Curcumin (diferuloylmethane), an orange-yellow component of turmeric or curry powder, is a polyphenol natural product isolated from the rhizome of the plant Curcuma longa...
  15. pmc Curcumin and cancer cells: how many ways can curry kill tumor cells selectively?
    Jayaraj Ravindran
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    AAPS J 11:495-510. 2009
    ..Traditional medicines are generally free of the deleterious side effects and usually inexpensive. Curcumin, a component of turmeric (Curcuma longa), is one such agent that is safe, affordable, and efficacious...
  16. ncbi Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models
    Thimmaraju Rudrappa
    Department of Plant and Soil Sciences, University of Delaware, Delaware Biotechnology Institute, Newark, DE 19711, USA
    J Agric Food Chem 56:1955-62. 2008
    The effect of curcumin on the virulence of Pseudomonas aeruginosa (PAO1) using whole plant and animal pathogenicity models was investigated...
  17. ncbi Up-regulation of heme oxygenase-1 expression through CaMKII-ERK1/2-Nrf2 signaling mediates the anti-inflammatory effect of bisdemethoxycurcumin in LPS-stimulated macrophages
    An Na Kim
    Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chuncheon 200 701, Korea
    Free Radic Biol Med 49:323-31. 2010
    ..that leads to the expression of heme oxygenase-1 (HO-1) in response to bisdemethoxycurcumin (BDMC), an analog of curcumin. Treatment with BDMC suppressed inducible nitric oxide synthase expression and nitric oxide (NO) production by ..
  18. ncbi Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells
    Murali Mohan Yallapu
    Cancer Biology Research Center, Sanford Research USD, Sioux Falls, SD 57105, USA
    J Colloid Interface Sci 351:19-29. 2010
    b>Curcumin, a natural polyphenolic compound, has shown promising chemopreventive and chemotherapeutic activities in cancer...
  19. ncbi Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways
    Hiroshi Aoki
    Department of Neurosurgery, University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Pharmacol 72:29-39. 2007
    ..Here, we examined the anticancer efficacy and mechanisms of curcumin, a natural compound with low toxicity in normal cells, in U87-MG and U373-MG malignant glioma cells...
  20. pmc Gemcitabine sensitivity can be induced in pancreatic cancer cells through modulation of miR-200 and miR-21 expression by curcumin or its analogue CDF
    Shadan Ali
    Division of Hematology Oncology, Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 70:3606-17. 2010
    b>Curcumin induces cancer cell growth arrest and apoptosis in vitro, but its poor bioavailability in vivo limits its antitumor efficacy...
  21. ncbi Curcumin and cancer: an "old-age" disease with an "age-old" solution
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Cancer Lett 267:133-64. 2008
    ..the active principles in them and how do they mediate their effects against cancer is perhaps best illustrated by curcumin, a derivative of turmeric used for centuries to treat a wide variety of inflammatory conditions...
  22. ncbi Curcumin--from molecule to biological function
    Tuba Esatbeyoglu
    Abteilung Lebensmittelwissenschaft, Institut fur Humanernahrung und Lebensmittelkunde, Christian Albrechts Universitat zu Kiel, Kiel, Deutschland
    Angew Chem Int Ed Engl 51:5308-32. 2012
    ..As a consequence of its intense yellow color, turmeric, or curcumin (food additive E100), is used as a food coloring (e.g. mustard)...
  23. ncbi Biological properties of curcumin-cellular and molecular mechanisms of action
    B Joe
    Department of Physiology and Molecular Medicine, Medical College of Ohio, Block Health Science Building, 3035 Arlington Avenue, Toledo, OH 43614 5804, USA
    Crit Rev Food Sci Nutr 44:97-111. 2004
    ..A vast majority of these studies were carried out with curcumin (diferuloyl methane), which is a major curcuminoid...
  24. pmc Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats
    Wei Yu
    Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    PLoS ONE 7:e52013. 2012
    ..The present study was sought to investigate the effect of curcumin on modulating DCM and the mechanisms involved.
  25. ncbi Multiple biological activities of curcumin: a short review
    Radha K Maheshwari
    Department of Pathology, Uniformed Services University of the Life Sciences, Center for Combat Casualty and Life Sustainment Research, Bethesda, Maryland 20814, USA
    Life Sci 78:2081-7. 2006
    ..These biological effects of turmeric have been attributed to its constituent curcumin that has been widely studied for its anti-inflammatory, anti-angiogenic, anti-oxidant, wound healing and anti-..
  26. pmc Dose escalation of a curcuminoid formulation
    Christopher D Lao
    Division of Hematology Oncology, Department of Internal Medicine, University of Michigan, 2150 CCGC, Ann Arbor, MI 48109 0930, USA
    BMC Complement Altern Med 6:10. 2006
    b>Curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that has broad anticarcinogenic and cancer chemopreventive potential...
  27. pmc Curcumin extract for prevention of type 2 diabetes
    Somlak Chuengsamarn
    Division of Endocrinology and Metabolism, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakharinwirot University, Nakornnayok, Thailand
    Diabetes Care 35:2121-7. 2012
    To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population.
  28. ncbi Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)
    Tauheed Ishrat
    Department of Emergency Medicine, Brain Research Laboratory, Emory University, Atlanta, GA 30322, USA
    Eur Neuropsychopharmacol 19:636-47. 2009
    Recent evidence indicates that curcumin (CUR), the principal curcuminoid of turmeric, exhibits antioxidant potential and protects the brain against various oxidative stressors...
  29. ncbi Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells
    Jie Yang
    Department of Nephrology, Tangdu Hospital, and Department of Immunology, The Fourth Military Medical University, Xi an, Shaanxi Province, China
    Med Oncol 27:1114-8. 2010
    The medicinal properties of curcumin are well documented in Indian and Chinese systems of medicine, which refer to its wide use in the treatment of some diseases...
  30. ncbi Curcumin induces apoptosis in human non-small cell lung cancer NCI-H460 cells through ER stress and caspase cascade- and mitochondria-dependent pathways
    Shin Hwar Wu
    Division of Critical Care Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan, ROC
    Anticancer Res 30:2125-33. 2010
    It has been reported that curcumin inhibited various types of cancer cells in vitro and in vivo...
  31. ncbi Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
    Balmiki Ray
    Laboratory of Molecular Neurogenetics, Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202, USA
    Curr Opin Pharmacol 9:434-44. 2009
    ..Turmeric is used as an anti-inflammatory medicine in various regions of Asia. Curcumin, which is a yellow colored polyphenol compound present in turmeric, showed anti-inflammatory properties...
  32. pmc Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
    Aynun N Begum
    Department of Medicine, University of California, Los Angeles, California, USA
    J Pharmacol Exp Ther 326:196-208. 2008
    b>Curcumin can reduce inflammation and neurodegeneration, but its chemical instability and metabolism raise concerns, including whether the more stable metabolite tetrahydrocurcumin (TC) may mediate efficacy...
  33. pmc Curcumin analogue CDF inhibits pancreatic tumor growth by switching on suppressor microRNAs and attenuating EZH2 expression
    Bin Bao
    Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 72:335-45. 2012
    ..In this study, we probed EZH2 function in pancreatic cancer using diflourinated-curcumin (CDF), a novel analogue of the turmeric spice component curcumin that has antioxidant properties...
  34. ncbi Phase II trial of curcumin in patients with advanced pancreatic cancer
    Navneet Dhillon
    Department of Investigational Cancer Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 14:4491-9. 2008
    ..We evaluated the clinical biological effects of curcumin (diferuloylmethane), a plant-derived dietary ingredient with potent nuclear factor-kappaB (NF-kappaB) and tumor ..
  35. pmc Anti-tumor activity of a novel compound-CDF is mediated by regulating miR-21, miR-200, and PTEN in pancreatic cancer
    Bin Bao
    Department of Pathology, Wayne State University, Detroit, Michigan, United States of America
    PLoS ONE 6:e17850. 2011
    ....
  36. pmc Curcumin protects retinal cells from light-and oxidant stress-induced cell death
    Md Nawajes A Mandal
    Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, 73104, USA
    Free Radic Biol Med 46:672-9. 2009
    ..In search of effective therapeutic agents, we tested curcumin, a naturally occurring compound with known anti-inflammatory and antioxidative properties, in a rat model of ..
  37. ncbi Curcumin: the story so far
    R A Sharma
    Cancer Biomarkers and Prevention Group, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester Royal Infirmary, Leicester LE2 7LX, UK
    Eur J Cancer 41:1955-68. 2005
    b>Curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric. It possesses diverse anti-inflammatory and anti-cancer properties following oral or topical administration...
  38. ncbi Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis
    Alok C Bharti
    Cytokine Research Section, Department of Bioimmunotherapy, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Blood 101:1053-62. 2003
    ..in human multiple myeloma (MM), we explored the possibility of using it as a target for MM treatment by using curcumin (diferuloylmethane), an agent known to have very little or no toxicity in humans...
  39. ncbi Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets
    Bharat B Aggarwal
    Cytokine Research Laboratory, Department of Experimental Therapeutics, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Trends Pharmacol Sci 30:85-94. 2009
    b>Curcumin (diferuloylmethane), a yellow pigment in the spice turmeric (also called curry powder), has been used for centuries as a treatment for inflammatory diseases...
  40. ncbi Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
    R Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, UK
    Free Radic Biol Med 28:1303-12. 2000
    b>Curcumin, a widely used spice and coloring agent in food, has been shown to possess potent antioxidant, antitumor promoting and anti-inflammatory properties in vitro and in vivo...
  41. pmc Therapeutic roles of curcumin: lessons learned from clinical trials
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1901 East Road, Unit 1950, Houston, TX 77054, USA
    AAPS J 15:195-218. 2013
    Extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (Curcuma longa), can modulate multiple cell signaling pathways...
  42. ncbi Curcumin alleviates oxidative stress, inflammation, and renal fibrosis in remnant kidney through the Nrf2-keap1 pathway
    Vivian Soetikno
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Mol Nutr Food Res 57:1649-59. 2013
    We hypothesized that curcumin, by increasing the expression of nuclear factor-erythroid-2-related factor 2 (Nrf2), could reduce oxidative stress, inflammation, and renal fibrosis in remnant kidney.
  43. ncbi Innovative preparation of curcumin for improved oral bioavailability
    Hiroki Sasaki
    Theravalues Corporation, Tokyo 102 0094, Japan
    Biol Pharm Bull 34:660-5. 2011
    b>Curcumin is a polyphenol that is commonly used for its perceived health benefits. However, the absorption efficacy of curcumin is too low to exhibit beneficial effects...
  44. pmc Curcumin protects retinal pigment epithelial cells against oxidative stress via induction of heme oxygenase-1 expression and reduction of reactive oxygen
    Je Moon Woo
    Department of Ophthalmology, Ulsan University Hospital, Ulsan, Republic of Korea
    Mol Vis 18:901-8. 2012
    To determine whether curcumin induces expression of the defensive enzyme heme oxygenase-1 (HO-1) and protects cells against oxidative stress in cultured human retinal pigment epithelial cells.
  45. ncbi Dietary curcumin inhibits atherosclerosis by affecting the expression of genes involved in leukocyte adhesion and transendothelial migration
    Dilek Coban
    INRA, UMR 1019, UNH, CRNH Auvergne, Clermont Ferrand, France
    Mol Nutr Food Res 56:1270-81. 2012
    The aim of the study was to examine the atheroprotective effect of dietary curcumin in a mouse model of atherosclerosis and to identify its cellular and molecular targets at the vascular level.
  46. ncbi Inhibition of LPS-induced production of inflammatory factors in the macrophages by mono-carbonyl analogues of curcumin
    Guang Liang
    School of Pharmacy, Wenzhou Medical College, College Town, Wenzhou, Zhejiang, China
    J Cell Mol Med 13:3370-9. 2009
    b>Curcumin (diferuloylmethane) is an orange-yellow compound from turmeric (Curcuma longa), a spice found in curry powder...
  47. pmc A potential role of the curry spice curcumin in Alzheimer's disease
    John M Ringman
    University of California, Los Angeles, Department of Neurology, Alzheimer s Disease Research Center, Los Angeles, CA 90095, USA
    Curr Alzheimer Res 2:131-6. 2005
    There is substantial in-vitro data indicating that curcumin has antioxidant, anti-inflammatory, and anti-amyloid activity...
  48. ncbi Curcumin ameliorates renal failure in 5/6 nephrectomized rats: role of inflammation
    S S Ghosh
    Department of Internal Medicine Nephrology, Sanger Hall, Rm 8 059, Virginia Commonwealth Univ, 1101 E Marshall St, Richmond, VA 23298, USA
    Am J Physiol Renal Physiol 296:F1146-57. 2009
    ..In hepatic cells, curcumin is shown to antagonize TNF-alpha-elicited NF-kappaB activation...
  49. ncbi Curcumin, a component of turmeric: from farm to pharmacy
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    Biofactors 39:2-13. 2013
    b>Curcumin, an active polyphenol of the golden spice turmeric, is a highly pleiotropic molecule with the potential to modulate the biological activity of a number of signaling molecules...
  50. ncbi Curcumin induces autophagy to protect vascular endothelial cell survival from oxidative stress damage
    Jing Han
    State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology School of Basic Medical Sciences, Peking University, Beijing, China
    Autophagy 8:812-25. 2012
    Our study first proposed that curcumin could protect human endothelial cells from the damage caused by oxidative stress via autophagy...
  51. ncbi Curcumin activates human glutathione S-transferase P1 expression through antioxidant response element
    Toru Nishinaka
    Laboratory of Biochemistry, Faculty of Pharmacy, Osaka Ohtani University, 3 11 1 Nishikiori kita, Tondabayashi, Osaka 584 8540, Japan
    Toxicol Lett 170:238-47. 2007
    b>Curcumin is a plant-derived diferuloylmethane compound extracted from Curcuma longa, possessing antioxidative and anticarcinogenic properties...
  52. pmc Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease
    Anila Mathew
    Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan
    PLoS ONE 7:e32616. 2012
    ..b>Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease...
  53. pmc Curcumin enhances the efficacy of chemotherapy by tailoring p65NFκB-p300 cross-talk in favor of p53-p300 in breast cancer
    Gouri Sankar Sen
    Division of Molecular Medicine, Bose Institute, P 1 12, Calcutta Improvement Trust Scheme VII M, Kolkata 700054, India
    J Biol Chem 286:42232-47. 2011
    ..Interestingly, curcumin pretreatment of drug-resistant cells alleviated SMAR1-mediated p65NFκB activation and hence restored doxorubicin ..
  54. ncbi Curcumin: the Indian solid gold
    Bharat B Aggarwal
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Adv Exp Med Biol 595:1-75. 2007
    ..b>Curcumin, which gives the yellow color to turmeric, was first isolated almost two centuries ago, and its structure as ..
  55. ncbi Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
    Kenjiro Ono
    Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Neurosci Res 75:742-50. 2004
    ..spectroscopic analysis with thioflavin T and electron microscopic studies, we examined the effects of curcumin (Cur) and rosmarinic acid (RA) on the formation, extension, and destabilization of fAbeta(1-40) and fAbeta(1-42) ..
  56. pmc Targeting colon cancer stem cells using a new curcumin analogue, GO-Y030
    L Lin
    Center for Childhood Cancer, The Research Institute at Nationwide Children s Hospital, Department of Pediatrics, Internal Medicine, College of Medicine, The Ohio State University, Columbus, OH 43205, USA
    Br J Cancer 105:212-20. 2011
    ..To date, whether STAT3 is activated and the effects of STAT3 inhibition by a newly developed curcumin analogue, GO-Y030, in colon cancer stem cells are still unknown.
  57. ncbi Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition
    Stephen J McNally
    Tissue Injury and Repair Group, University of Edinburgh, Chancellor s Building, Little France, Edinburgh EH16 4SB, UK
    Int J Mol Med 19:165-72. 2007
    b>Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated...
  58. pmc The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats
    Tatsuya Morimoto
    Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
    J Clin Invest 118:868-78. 2008
    ..It has been previously shown that curcumin, a polyphenol responsible for the yellow color of the spice turmeric, possesses HAT inhibitory activity with ..
  59. ncbi Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice
    Tozo Nishiyama
    Functional Foods Development Division, and Life Science Research Laboratories, Life Science RD Center, Kaneka Corporation, Takasago, Hyogo 676 8688, Japan
    J Agric Food Chem 53:959-63. 2005
    ..Also, curcumin, demethoxycurcumin, bisdemethoxycurcumin, and ar-turmerone had PPAR-gamma ligand-binding activity...
  60. ncbi Curcumin in cancer chemoprevention: molecular targets, pharmacokinetics, bioavailability, and clinical trials
    Adeeb Shehzad
    School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Taegu, Korea
    Arch Pharm (Weinheim) 343:489-99. 2010
    b>Curcumin (diferuloylmethane), a derivative of turmeric is one of the most commonly used and highly researched phytochemicals...
  61. ncbi Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, Unit 143, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Biochem Pharmacol 76:1590-611. 2008
    b>Curcumin, a yellow pigment present in the Indian spice turmeric (associated with curry powder), has been linked with suppression of inflammation; angiogenesis; tumorigenesis; diabetes; diseases of the cardiovascular, pulmonary, and ..
  62. ncbi The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin
    D L French
    Department of Radiology, McMaster University, Hamilton, Ontario, Canada
    Phytomedicine 15:1069-78. 2008
    ..of this study were to evaluate an animal model of postmenopausal osteoporosis and to search for evidence that curcumin reduces bone mineral losses in a dose-dependent manner when endogenous estrogen levels are reduced...
  63. ncbi Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
    Kyeongjin Kim
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea
    FEBS Lett 584:707-12. 2010
    A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus...
  64. pmc Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK
    Nathan M Weir
    Davis Heart and Lung Research Institute and Comprehensive Cancer Center, Department of Internal Medicine, Ohio State University, Columbus, OH 43210, USA
    Cancer Biol Ther 6:178-84. 2007
    b>Curcumin, a major active component of turmeric, is known to induce apoptosis in several types of cancer cells, but little is known about its activity in chemoresistant cells...
  65. ncbi Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies
    Jenny Epstein
    Centre for Digestive Diseases, Institute of Cell and Molecular Science, Barts and the London School of Medicine, Queen Mary, University of London, 4 Newark Street, London E1 2AT, UK
    Br J Nutr 103:1545-57. 2010
    b>Curcumin is the active ingredient of turmeric. It is widely used as a kitchen spice and food colorant throughout India, Asia and the Western world...
  66. pmc Curcumin: A review of anti-cancer properties and therapeutic activity in head and neck squamous cell carcinoma
    Reason Wilken
    Department of Surgery, VA Greater Los Angeles Healthcare System, West Los Angeles, CA, USA
    Mol Cancer 10:12. 2011
    b>Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant, commonly known as turmeric...
  67. pmc Curcumin nanoformulations: a future nanomedicine for cancer
    Murali M Yallapu
    Cancer Biology Research Center, Sanford Research University of South Dakota, 2301 E 60th Street North, Sioux Falls, SD 57104, USA
    Drug Discov Today 17:71-80. 2012
    b>Curcumin, a natural diphenolic compound derived from turmeric Curcuma longa, has proven to be a modulator of intracellular signaling pathways that control cancer cell growth, inflammation, invasion and apoptosis, revealing its anticancer ..
  68. pmc Curcumin modulates microRNA-203-mediated regulation of the Src-Akt axis in bladder cancer
    Sharanjot Saini
    Department of Urology, Veterans Affairs Medical Center, University of California, San Francisco, USA
    Cancer Prev Res (Phila) 4:1698-709. 2011
    ..b>Curcumin (diferuloylmethane) is a natural compound that has been known to possess anticancer properties in various cancers,..
  69. pmc Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo
    Preetha Anand
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Biochem Pharmacol 79:330-8. 2010
    b>Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with antioxidant, anti-inflammatory, antiproliferative, anticancer, antidiabetic, antirheumatic, and antiviral effects, but its optimum potential is ..
  70. ncbi Curcumin-mediated lifespan extension in Caenorhabditis elegans
    Vivian Hsiu Chuan Liao
    Department of Bioenvironmental Systems Engineering, National Taiwan University, No 1 Roosevelt Road, Sec 4, Taipei 106, Taiwan
    Mech Ageing Dev 132:480-7. 2011
    b>Curcumin is the active ingredient in the herbal medicine and dietary spice, turmeric (Curcuma longa). It has a wide range of biological activities, including anti-inflammatory, antioxidant, chemopreventive, and chemotherapeutic activities...
  71. ncbi Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance
    Ricky A Sharma
    Oncology Department, University of Leicester, Leicester, United Kingdom
    Clin Cancer Res 10:6847-54. 2004
    b>Curcumin, a polyphenolic antioxidant derived from a dietary spice, exhibits anticancer activity in rodents and in humans...
  72. ncbi Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia
    Chenhui Yang
    Department of Neurology, Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
    Brain Res 1282:133-41. 2009
    ..b>Curcumin is proved to elicit a vanity of biological effects through its antioxidant and anti-inflammatory properties...
  73. ncbi Curcumin extends life span, improves health span, and modulates the expression of age-associated aging genes in Drosophila melanogaster
    Kyu Sun Lee
    Aging Research Center, Korean Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Rejuvenation Res 13:561-70. 2010
    b>Curcumin, an extract from the rhizome of the plant Curcuma longa (turmeric), has been widely used as a spice and herbal medicine in Asia...
  74. ncbi Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases
    Stig Bengmark
    Institute of Hepatology, University College, London Medical School, London, United Kingdom
    JPEN J Parenter Enteral Nutr 30:45-51. 2006
    ..Drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest...
  75. ncbi Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells
    Michael Sun
    Department of Investigational Cancer Therapeutics Phase I Program, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Ther 7:464-73. 2008
    ..With its low toxicity profile, curcumin (diferuloylmethane), a naturally occurring flavinoid derived from the rhizome of Curcuma longa, has great promise...
  76. pmc Inhibition of NFkappaB and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein down-regulation
    Indira Jutooru
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, College Station, Texas 77843, USA
    J Biol Chem 285:25332-44. 2010
    b>Curcumin activates diverse anticancer activities that lead to inhibition of cancer cell and tumor growth, induction of apoptosis, and antiangiogenic responses. In this study, we observed that curcumin inhibits Panc28 and L3...
  77. ncbi Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
    Ajay Goel
    Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, USA
    Nutr Cancer 62:919-30. 2010
    b>Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and ..
  78. ncbi Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products
    Ajaikumar B Kunnumakkara
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Cancer Res 67:3853-61. 2007
    ..b>Curcumin, a component of turmeric (Curcuma longa), is one such agent that has been shown to suppress the transcription ..
  79. pmc Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus
    So Jung Kim
    Department of Pharmacy, College of Pharmacy and Research Institute for Drug Development, Longevity Life Science and Technology Institutes, Pusan National University, Geumjeong Gu, Busan, Korea
    J Biol Chem 283:14497-505. 2008
    b>Curcumin is a natural phenolic component of yellow curry spice, which is used in some cultures for the treatment of diseases associated with oxidative stress and inflammation...
  80. ncbi Curcumin inhibits melanogenesis in human melanocytes
    Cai Xia Tu
    Department of Dermatology, 2nd Affiliated Hospital of Dalian Medical University, Liaoning 116027, PR China
    Phytother Res 26:174-9. 2012
    ..b>Curcumin is a plant-derived polyphenol, which has been reported to suppress melanogenesis in B16 melanoma cells...
  81. ncbi Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications
    Bo Meng
    Department of Anesthesiology, the Second Affiliated Hospital of Wenzhou Medical College, 325027, Wenzhou, Zhejiang Province, China
    Curr Pharm Des 19:2101-13. 2013
    ..b>Curcumin, a phytochemical found in the spice turmeric, has been used in India for centuries, and it has no known side ..
  82. pmc Curcumin induces cell death in esophageal cancer cells through modulating Notch signaling
    Dharmalingam Subramaniam
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America
    PLoS ONE 7:e30590. 2012
    b>Curcumin inhibits the growth of esophageal cancer cell lines; however, the mechanism of action is not well understood...
  83. pmc Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent
    Vineshkumar T Puliyappadamba
    Integrated Cancer Research Program, Division of Cancer Research, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India
    Mol Cancer 9:220. 2010
    ....
  84. pmc Phase IIa clinical trial of curcumin for the prevention of colorectal neoplasia
    Robert E Carroll
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Prev Res (Phila) 4:354-64. 2011
    b>Curcumin is derived from the spice tumeric and has antiinflammatory and antineoplastic effects in vitro and in animal models, including preventing aberrant crypt foci (ACF) and adenomas in murine models of colorectal carcinogenesis...
  85. pmc Discovery of curcumin, a component of golden spice, and its miraculous biological activities
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Clin Exp Pharmacol Physiol 39:283-99. 2012
    1. Curcumin is the active ingredient of the dietary spice turmeric and has been consumed for medicinal purposes for thousands of years...
  86. pmc Curcumin is a potent modulator of microglial gene expression and migration
    Marcus Karlstetter
    Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    J Neuroinflammation 8:125. 2011
    ..b>Curcumin, a major component of tumeric, alleviates pro-inflammatory activities of these cells by inhibiting nuclear factor ..
  87. ncbi Curcumin-phospholipid complex: Preparation, therapeutic evaluation and pharmacokinetic study in rats
    Kuntal Maiti
    School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700 032, India
    Int J Pharm 330:155-63. 2007
    A novel formulation of curcumin in combination with the phospholipids was developed to overcome the limitation of absorption and to investigate the protective effect of curcumin-phospholipid complex on carbon tetrachloride induced acute ..
  88. ncbi Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells
    Ratul Kumar Das
    Department of Biotechnology, Indian Institute of Technology Guwahati, Assam, India
    Nanomedicine 6:153-60. 2010
    We report a nanoformulation of curcumin with a tripolymeric composite for delivery to cancer cells...
  89. ncbi Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
    Ying Xu
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA
    Brain Res 1162:9-18. 2007
    ..As the active component of curcuma longa, curcumin possesses many therapeutic properties; we have previously described its antidepressant activity in our earlier ..
  90. ncbi The effect of curcumin on insulin release in rat-isolated pancreatic islets
    Mohamed T Abdel Aziz
    Department of Medical Biochemistry, Cairo University, Egypt
    Angiology 61:557-66. 2010
    b>Curcumin exerts a hypoglycemic action and induces heme-oxygenase-1 (HO-1). We evaluated the effect of curcumin on isolated islets of Langerhans and studied whether its action on insulin secretion is mediated by inducible HO-1...
  91. ncbi Curcumin inhibits hepatitis B virus via down-regulation of the metabolic coactivator PGC-1alpha
    Maya Mouler Rechtman
    The Institute of Gastroenterology and Liver Disease, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    FEBS Lett 584:2485-90. 2010
    ..Here we show that treating HBV expressing cells with the natural phenolic compound curcumin inhibits HBV gene expression and replication...
  92. ncbi Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis
    Laura Camacho-Barquero
    Department of Pharmacology, School of Pharmacy, University of Seville, Profesor García González Street, 2, 41012 Seville, Spain
    Int Immunopharmacol 7:333-42. 2007
    ..b>Curcumin is a polyphenol derived from Curcuma longa, which is known to have anti-inflammatory activity...
  93. ncbi Curcumin: an anti-inflammatory molecule from a curry spice on the path to cancer treatment
    Purusotam Basnet
    Drug Transport and Delivery Research Group, Department of Pharmacy, University of Tromsø, Tromsø N 9037, Norway
    Molecules 16:4567-98. 2011
    ..be prevented or significantly reduced by treatment with anti-oxidant and anti-inflammatory drugs, therefore, curcumin, a principal component of turmeric (a curry spice) showing strong anti-oxidant and anti-inflammatory activities, ..
  94. pmc Curcumin modulates nuclear factor kappaB (NF-kappaB)-mediated inflammation in human tenocytes in vitro: role of the phosphatidylinositol 3-kinase/Akt pathway
    Constanze Buhrmann
    Institute of Anatomy, Ludwig Maximilian University Munich, 80336 Munich, Germany
    J Biol Chem 286:28556-66. 2011
    ..Recent studies in various cell models have demonstrated that curcumin targets the NF-κB signaling pathway...
  95. ncbi Protective effect of curcumin against lead neurotoxicity in rat
    Pradeep K Shukla
    Industrial Toxicology Research Centre, PO Box 80, MG Marg, Lucknow 226001, India
    Hum Exp Toxicol 22:653-8. 2003
    b>Curcumin (diferuloylmethane), an active ingredient of turmeric, is known to have multiple activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases...
  96. pmc Curcumin prevents aggregation in α-synuclein by increasing reconfiguration rate
    Basir Ahmad
    Department of Physics and Astronomy, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 287:9193-9. 2012
    ..In this work, we examined the ability of curcumin, a compound found in turmeric, to prevent aggregation of the protein...
  97. pmc Intracellular ROS protection efficiency and free radical-scavenging activity of curcumin
    Abolfazl Barzegar
    Research Institute for Fundamental Sciences RIFS, University of Tabriz, Tabriz, Iran
    PLoS ONE 6:e26012. 2011
    b>Curcumin has many pharmaceutical applications, many of which arise from its potent antioxidant properties...
  98. ncbi Biological effects of curcumin and its role in cancer chemoprevention and therapy
    Sarvjeet Singh
    Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, India
    Anticancer Agents Med Chem 6:259-70. 2006
    b>Curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents...
  99. pmc Multitargeting by curcumin as revealed by molecular interaction studies
    Subash C Gupta
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, 77030, USA
    Nat Prod Rep 28:1937-55. 2011
    b>Curcumin (diferuloylmethane), the active ingredient in turmeric (Curcuma longa), is a highly pleiotropic molecule with anti-inflammatory, anti-oxidant, chemopreventive, chemosensitization, and radiosensitization activities...
  100. ncbi Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability
    Hanne Hjorth Tønnesen
    Institute of Pharmacy, University of Oslo, P O Box 1068 Blindern, 0316 Oslo, Norway
    Int J Pharm 244:127-35. 2002
    Cyclodextrin complexes of the natural compound curcumin were prepared in order to improve the water solubility and the hydrolytic and photochemical stability of the compound...
  101. ncbi Curcumin loaded pH-sensitive nanoparticles for the treatment of colon cancer
    Dandekar Prajakta
    Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N P Marg, Matunga, Mumbai 400019, India
    J Biomed Nanotechnol 5:445-55. 2009
    The investigation was aimed at designing pH-sensitive, polymeric nanoparticles of curcumin, a natural anti-cancer agent, for the treatment of colon cancer...

Research Grants77

  1. Anti-tumor properties of curcumin in oral cancers: role of thioredoxin reductase
    STEPHEN WILLIAM TUTTLE; Fiscal Year: 2010
    ..b>Curcumin is a naturally occurring plant polyphenolic antioxidant with potent chemopreventive and antintumorigenic ..
  2. Nitric Oxide Restoration &Heme Detoxification as Adjunctive Therapies for Cerebr
    LEONARDO JOSE DE MOURA CARVALHO; Fiscal Year: 2012
    ..hemopexin, protoporphyrin IX and mesoporphyrin IX), inducing hemeoxygenase-1 (HO-1: hyperbaric oxygen, curcumin, furan-2-yl-3-pyridin-2-yl-propenone, -deoxy-delta 12,14-prostaglandin J2) or providing anti-oxidant protection ..
  3. Memory and Mood Enhancing Therapies for Gulf War Illness
    Ashok K Shetty; Fiscal Year: 2013
    ..test the hypothesis that combined applications of an anti-depressant drug (FLU or ROL) and an antioxidant drug (Curcumin [CUR] or Resveratrol [RESV];dietary supplements having anti-oxidant, anti-inflammatory, and neurogenesis ..
  4. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ..novel ELP-based depots to provide for sustained release of a safe, small molecule inhibitor of inflammation - curcumin. We propose that an injectable, in situ forming curcumin drug depot will provide for rapid reversal of symptoms ..
  5. Reactivation of Tumor Suppressor Genes in Breast Cancer by Dietary Supplements as
    Zhongfa Liu; Fiscal Year: 2010
    ..of both global and specific promoter DNA methylation levels established on our group, parthenolide and curcumin have been found to possess DNA hypomethylation activity...
  6. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..sulforaphane (SFN) and phenethyl isothiocyanate (PEITC)] and the anti-inflammatory [the beta diketones, curcumin (CUR) and dibenzoylmethane (DBM)] effects, alone or in combination against colorectal cancer...
  7. Curcumin and chemoprevention of H. pylori-associated gastric carcinogenesis
    Rupesh Chaturvedi; Fiscal Year: 2013
    ..This application will facilitate understanding f the molecular mechanisms underlying the action of curcumin in protecting the host from H. pylori infection and associated pathology. H...
  8. Clinical Translation of Curcumin Therapy to Treat Arterial Aging
    Douglas R Seals; Fiscal Year: 2013
    ..b>Curcumin is a naturally occurring polyphenol found in the Indian spice turmeric that improves physiological function in ..
  9. Epigenetic modifications by dietary PEITC in prostate cancer
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..During the previous funding period, we have found that phenethyl isothiocyanate (PEITC) and curcumin (CUR) alone and in combination inhibit the development and progression of PCa in nude mice PC-3 xenograft and ..
  10. Broadly Neuroprotective Drug for TBI
    Fernando Gomez Pinilla; Fiscal Year: 2010
    ..identification and validation of sensitive and predictive biomarkers to evaluate status of a specific nutrient (curcumin derivative)...
  11. Pharmacokinetics and Metabolism of Oxidized Curcumin
    Claus Schneider; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Curcumin, a polyphenol isolated from the plant turmeric, is recognized for its anti-inflammatory and anti- tumorigenic bioactivities...
  12. Chemoprotective effects of natural products on colonic adult stem cells
    Bhimanagouda S Patil; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have demonstrated that chemoprotective diets containing turmeric (curcumin) and citrus (limonin) bioactives reduce chronic inflammation and colon cancer risk...
  13. Targeted Delivery of a Novel Synthetic Curcumin Analog, EF24 to Glioblastoma and
    MAMORU NONE SHOJI; Fiscal Year: 2012
    ..The cytotoxic agent we have developed is EF24, a synthetic curcumin analog, which will be linked to enzymatically inactive coagulation factor VIIa (fVIIa), the high affinity ligand ..
  14. Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 Interaction
    Longqin Hu; Fiscal Year: 2010
    ..Keap1-Nrf2 interaction plays a key role in cancer chemoprevention by many chemicals like sulforaphane, curcumin, and epigallocatechin gallate derived from natural sources such as fruits, vegetables, and tea products...
  15. Intestinal Barrier Function: Protective Effects of Curcumin
    Pawel R Kiela; Fiscal Year: 2013
    ..In this proposal, we hypothesize that curcumin improves intestinal barrier through inhibition of IFN-? signaling in the CEC, inhibition of neutrophil ..
  16. Mechanisms of Mitochondrial Dysfunction in Brain Vasculature
    Neetu Tyagi; Fiscal Year: 2013
    ..Interestingly, THC decreases Hcy level and mitigates brain damage. Tetra hydro-curcumin (THC), a major herbal antioxidant and anti-inflammatory agent, has shown to protect brain against I/R injury...
  17. Apoptosis pathways underlying adipogenesis
    Niketa A Patel; Fiscal Year: 2013
    ..PKC4II, a serine/threonine protein kinase promotes cell survival. Natural compounds such as resveratrol and curcumin exhibit anti-adipogenic activities and promote apoptosis in adipocytes...
  18. Phytochemicals &Metabolism in Pancreatic Diseases/Pandol, Stephen
    Vay Liang W Go; Fiscal Year: 2011
    ..The experiments in this project are designed to test the effect of each of rottlerin, ellagic acid, embelin, curcumin and lycopene on regulating the proliferative metabolic phenotype of the pancreatic stellate and cancer cells;and ..
  19. Polyphenolic Interventions for tau Pathogenesis in Alzheimers Models
    SALLY ANN FRAUTSCHY; Fiscal Year: 2013
    ..Recent data from our lab and others implicate soluble tau oligomers. Our data show that curcumin selectively reduces soluble tau dimers, and transgene dependent defects in heat shock proteins (HSPs), behavior, ..
  20. Curcuma Longa: epigenetic effects in prostate and colon cancer
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..L.), usually contain three major components, curcumin (CUR;~77%), demethoxycurcumin (~17%) and bis-demethoxycurcumin (~3%), they are commonly used as botanical dietary ..
  21. Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy
    ROBERT D BOWLES; Fiscal Year: 2013
    ..In Aim 2, the therapeutic efficacy of curcumin as an NF-kB inhibitor will be evaluated following CCI via noninvasive, in vivo imaging and markers of function ..
  22. Chemosensitization of Pancreatic Cancer Cells by Curcumin and Vitamin D Receptor
    TIMOTHY YEN; Fiscal Year: 2013
    ..This proposal seeks to extend the recent finding that the natural compound curcumin is a ligand for VDR...
  23. Identification and therapeutic application of miRNA-drivers in lung cancer
    ANDREA LYNN KASINSKI; Fiscal Year: 2013
    ..Kasinski utilized biochemical assays to identified IKK-[unreadable] as a direct target of EF24, an analogue of curcumin that ultimately made its way into clinical trials...
  24. Curcumin chemoprevention in familial adenomatous polyposis
    Francis M Giardiello; Fiscal Year: 2013
    ..b>Curcumin is the major yellow pigment extracted from turmeric the powdered root of the herb Curcuma longa...
  25. Curcumin and Quercetin in Colon Cancer: Role of Macrophage-Induced Inflammation
    ELIZABETH ANGELA MURPHY; Fiscal Year: 2010
    ..The consumption of the anti- inflammatory dietary constituents curcumin, which is a component of the Indian spice currie, and quercetin, a flavonoid present in various fruits and ..
  26. Lupus Association with Signal Transducer and Activator of Transcription 4
    JOHN BARKER HARLEY; Fiscal Year: 2013
    ..Initially, we will explore the potential impact on STAT4 activity with the known inhibitors (lisopfylline, curcumin, and statins)...
  27. Synthesis and Characterization of Polymeric Antioxidant microparticles for the pr
    NIHAR MANILAL SHAH; Fiscal Year: 2013
    ..A potent antioxidant, such as curcumin, may represent an exciting therapeutic agent in OM prevention as a direct inhibitor of the earliest phase of OM ..
  28. Silk Fibroin Small-Molecule Drug Carriers for the Treatment of Osteoarthritis
    TIMOTHY KARIITHI MWANGI; Fiscal Year: 2013
    ..b>Curcumin is a small di-phenol that inhibits inflammation in many cell types and will be used as a model drug here...
  29. Curcumin inhbits BPDE-induced damage by lowering the threshold of p53 activation
    ERICA NICOLE ROGERS; Fiscal Year: 2011
    ..While dietary components such as curcumin (turmic spice) show promising effects against BPDEinduced carinogenesis, its exact mode of action is not fully ..
  30. Diet and Exercise (DE) Program for Alzheimer Prevention
    SALLY ANN FRAUTSCHY; Fiscal Year: 2010
    ..Our data suggest that the omega-3 fatty acid docosahexaenoic acid (DHA) and the phenolic antioxidant curcumin (from turmeric) synergize to reduce AD pathogenesis in both APP/ A[unreadable] and tau pathology models...
  31. Assessment of Biomarkers and Behavior in a Transgenic Rat Model of AD
    EDMOND HUATUNG TENG; Fiscal Year: 2013
    ..We further hypothesize that these changes will be differentially modulated by treatment with curcumin or docosahexaenoic acid (DMA) and will be affected by both the duration of treatment and the severity of disease ..
  32. Restoration of Homeostasis After Brain Trauma
    Fernando Gomez-Pinilla; Fiscal Year: 2013
    ..In turn, the curry spice curcumin, traditionally known in Asia for its medicinal power, has been shown in our hands to promote energy homeostasis ..
  33. Targeting both intrinsic and extrinsic apoptosis by FLLL-12 in lung cancer
    A R M Ruhul Amin; Fiscal Year: 2013
    ..Extensive preclinical research over the last several decades has demonstrated that curcumin has strong potential for chemoprevention, which brought this agent into clinical trials...
  34. Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    Gregory M Cole; Fiscal Year: 2013
    ..Aim 2) Determine if limited DHA efficacy (especially with ApoE4 carriers) is improved with lipoate, curcumin or the combination, Aim 3) Identify ApoE isoform-dependent plasma biomarkers that our data suggest reflect ..
  35. Development of a Melanoma Chemoprevention Model
    Christopher D Lao; Fiscal Year: 2010
    ..can be used to test putative Chemoprevention agents by modulating important molecular events and that topical curcumin can delay or prevent transformation and progression of melanocytes in humans at least in part by its modulating ..
  36. Amyloid-Lowering Small Molecule AB-Binding Agents in AD
    William E Klunk; Fiscal Year: 2010
    ..agents are third and fourth generation Congo red derivatives that structurally resemble the natural product, curcumin. As part of a program to develop in vivo amyloid imaging agents, these compounds were designed to have high ..
  37. Colorectal cancer chemoprevention with phytochemical combinations
    Swati Nagar; Fiscal Year: 2013
    ..Phytochemical combinations trans-resveratrol + curcumin and trans-resveratrol + chrysin in ratios based on individual antiproliferative IC50s will be tested and compared ..
  38. Oxidative Metabolites of Curcumin and their Biological Activity
    ODAINE GORDON; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Curcumin, the polyphenolic yellow pigment from the turmeric plant, exhibits anti-inflammatory, antioxidant, and anticancer effects in vitro and in animal models...
  39. Curcumin to Augment Neonatal Lung Injury/Repair
    Reiko Sakurai; Fiscal Year: 2012
    ..b>Curcumin [1,7-bis (4'-hydroxy-3'-methoxyphenyl)-1,6-heptadiene-3,5-dione], a naturally occurring pigment derived ..
  40. A noninvasive optical imaging of retinal amyloid beta deposits in AD patients
    Maya Koronyo-Hamaoui; Fiscal Year: 2013
    ..Further development of a novel noninvasive retinal imaging approach by our team to detect these plaques by curcumin labeling in live AD transgenic mouse models, allowed for the in vivo imaging of Abeta plaques at unprecedented ..
  41. Development of a novel NF-kB antagonist to block cytokine-induced behavioral chan
    THADDEUS W PACE; Fiscal Year: 2010
    ..the efficacy of UBS109, a water soluble nuclear factor kappa B (NF-kB ) antagonist structurally related to curcumin, the principal curcuminoid of the Indian curry spice turmeric, to block CNS and behavioral changes in an animal ..
  42. AnnexinA2/progastrin and stem cells: dietary cancer prevention
    Pomila Singh; Fiscal Year: 2013
    ..Our preliminary studies suggest that curcumin significantly reduces expression of ANXA2 and stem cell markers;intriguingly opposite effects of curcumin were ..
  43. Identification of Natural Product Inhibitors of Breast Cancer Bone Metastasis
    Janet L Funk; Fiscal Year: 2012
    ..consumption is of interest given existing scientific evidence that one particular chemical found in turmeric, curcumin, can prevent cancer cell growth...
  44. Radiation injury to the heart
    John E Baker; Fiscal Year: 2010
    ..Furthermore, the pharmaceutical Losartan and the nutriceutical curcumin appear to prevent TBI-induced development of risk factors for cardiovascular disease...
  45. Differentiation and Elimination of Chemo-surviving Colon Tumors
    ADHIP N MAJUMDAR; Fiscal Year: 2013
    ..renders the FUOX-resistant colon cancer cells susceptible not only to FUOX but also to 3, 4-difluorobenzo-curcumin or difluorinated curcumin (CDF) and the combination of CDF and FUOX...
  46. APC mutation and breast cancer: Prevention by curcumin
    Meena Katdare; Fiscal Year: 2010
    ..We have shown that the altered molecular markers for tumorigenicity can be prevented by dietary agent, Curcumin, the yellow curry powder extensively used in Asian countries...
  47. Prevention of Tumor Progression by a Novel Approach
    Fazlul H Sarkar; Fiscal Year: 2013
    ..To that end, we have published, for the first time, that a synthetic analog of a non-toxic natural agent curcumin, named CDF is superior in its target tissue (pancreas) bioavailability without any adverse side effects, and the ..
  48. Anti-Promoting Effects of Triterpenes Alone or Combined with Other Phytochemicals
    Thomas J Slaga; Fiscal Year: 2013
    ..frutescens) when combined with other phytochemicals such as Res, curcumin (Curc), 6-shogaol (6Sho) or Rapa will produce either additive or possibly synergistic chemopreventive effects...
  49. Imaging AD Amyloidosis Pathology by Novel Multi-modal NIR/PET/19F MRI Probes
    Chongzhao Ran; Fiscal Year: 2013
    ..b>Curcumin, the principal curcuminoid of the Indian curry, has been used for ex vivo detection of amyloid deposits...
  50. The Role of Aryl Hydrocarbon Receptor in Colon Tumorigenesis
    GREGORY DEAN KENNEDY; Fiscal Year: 2013
    ..chemoprotective agents includes naturally occurring dietary compounds such as indole-3- carbinol, chrysin and curcumin, as well as therapeutic agents like Sulindac and other NSAIDs...
  51. Pancreatic Cancer Therapy with GRP Receptor-Targeted Imageable Diphenyl difluorok
    Vibhudutta Awasthi; Fiscal Year: 2010
    ..We are developing a series of curcumin-based antiproliferative drugs including a diphenyl difluoroketone (DPDK) compound...
  52. The effect of curcumin on age-related cognitive decline in the rhesus monkey
    MARK BARRY MOSS; Fiscal Year: 2013
    ..Toward this evolving hypothesis, Curcumin, a natural phenol and member of the ginger family, has been shown to evidence such positive effects and provide a ..
  53. Inflammatory Mediators of Prostate Cancer Metastasis and Responses to Curcumin
    Magaly Martinez-Ferrer; Fiscal Year: 2013
    ..that predict biochemical recurrence of prostate cancer regulate metastatic progression of the cancer and curcumin can inhibit metastasis of prostate cancer...
  54. Oxidative activation of the dietary cancer chemopreventive agent curcumin
    Claus Schneider; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Curcumin, a polyphenol isolated from the plant turmeric, is recognized for its antioxidant, anti-inflammatory and anti-tumorigenic bioactivities...
  55. Effects of UBS109, a novel NF-kappaBeta inhibitor, on depressive-like behaviors
    ANLYS OLIVERA; Fiscal Year: 2010
    ..Work in the sponsor's laboratory is focused on the development of anologues of curcumin, a component of the Indian spice, turmeric, which improve upon curcumin's anti-NF-kB activity as well as its ..
  56. Curcuma longa L. in Rheumatoid Arthritis (CLaRA): Clinical Planning Study
    Janet L Funk; Fiscal Year: 2013
    ..NCCAM has identified as a high priority research area the evaluation of various formulations of turmeric/curcumin for the treatment of musculoskeletal pain, including comparisons of bioavailability and pharmacokinetic ..
  57. Curcumin: A Multi-Mechanism HIV Microbicide
    Raju C Reddy; Fiscal Year: 2009
    ..Among the compounds being investigated for this purpose, the turmeric- derived polyphenol curcumin is particularly promising because it inhibits HIV replication by several mechanisms...
  58. Curcumin and Piperine in Breast Cancer Prevention
    Madhuri Kakarala; Fiscal Year: 2011
    ..b>Curcumin, a potent cancer preventive polyphenol, prevents cellular carcinogenesis progression via a diverse set of ..
  59. Mechanism of inhibition of APP processing and amyloid formation
    STEVEN OWEN SMITH; Fiscal Year: 2013
    ..The small molecule inhibitors include the natural products, curcumin and resveratrol. The peptide inhibitors are designed on the basis of the structure of the A? fibrils...
  60. AYURVEDIC ALTERNATIVES IN AUTOIMMUNITY
    Chandra Mohan; Fiscal Year: 2010
    ..Based on its efficacy in several other chronic diseases, the Ayurvedic supplement, curcumin holds great promise in lupus treatment - however, this has never been tested directly...
  61. Curcumin reverses tumor exosomes-mediated inhibition of myeloid differentiation
    Huang Ge Zhang; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The naturally occurring polyphenol, curcumin, has been shown to be a potent chemotherapeutic agent in a variety of tumor models;however, its effects on tumor-associated immunosuppression have not been ..
  62. Synergistic anticancer effects of docosahexanoic acid and curcumin
    RAFAT ALI SIDDIQUI; Fiscal Year: 2010
    ..we propose to investigate the synergistic effects of two dietary components: docosahexaenoic acid (DHA) and curcumin (CCM)...
  63. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2004
    ..However, one of the major active principles in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions...
  64. URINALYSIS FOR PATIENT COMPLIANCE TO CAM THERAPY
    Rama Ramanujam; Fiscal Year: 2006
    ..CAM agents, such as curcumin, are known to inhibit I-kappaB phosphorylation, thereby inhibiting NFkappaB activation and suppressing ..
  65. Curcumin/Bioperine in Multiple Myeloma
    Saroj Vadhan Raj; Fiscal Year: 2005
    Extensive research over the past 5 decades has suggested the therapeutic potential of curcumin (diferuloylmethane), a polyphenol derived from the plant Curcuma Ionga, in the prevention and treatment of cancer based on its in vitro and in ..
  66. Novel Antioxidants for Treatment of Diabetic Retinopathy
    Danyang Chen; Fiscal Year: 2009
    ..b>Curcumin, a polyphenolic compound derived from dietary spice turmeric, has a wide range of pharmacologic effects, ..
  67. NITRIC OXIDE INHIBITOR AND LEISHMANIA PATHOGENESIS
    MARION CHAN; Fiscal Year: 2000
    ..However, one of the major active principles in turmeric is curcumin, an inhibitor of nitric oxide production and a scavenger of nitric oxide and superoxide anions...
  68. Targeting Egr-1 with Curcumin Analogs for Prostate Cancer Prevention
    Marco Bisoffi; Fiscal Year: 2009
    Targeting Egr-1 with Curcumin Analogs for Prostate Cancer Prevention Bisoffi, Marco Project Summary The problem addressed in this proposal: Field cancerization, i.e...
  69. Mechanistic Studies on the Disposition of Farnesol with Single and Multiple Dosin
    Thomas Cook; Fiscal Year: 2007
    ..Many cancer prevention agents isolated from foods have wide safety margins such as curcumin, sulforaphane, and perillyl alcohol...
  70. MECHANISMS FOR CHEMOPREVENTION OF COLON CANCER
    CHINTHALAPALLY RAO; Fiscal Year: 2004
    ..the proposal is to elucidate the inhibitory mechanisms in colon carcinogenesis by the naturally occurring agents curcumin and phenylethyl-3-methylcaffeate (PEMC). Colon cancer is the second most common malignancy in the Western world...
  71. DIETARY PLANT PHENOLICS--EFFECT ON COLONIC BIOMARKERS
    STEVEN SHIFF; Fiscal Year: 1999
    ..ingredients contained within these foods are likely abundant, the plant-derived phenolic compounds such as curcumin, rutin, and quercetin, are particularly compelling compounds to study...
  72. INHIBITION OF PROGESTIN-DEPENDENT ANGIOGENESIS IN BREAST CANCER
    CANDACE CARROLL; Fiscal Year: 2009
    ..There is growing evidence that the Indian spice, curcumin, and the estrogen metabolite 2-methoxyestradiol (2-ME2), function as anti-angiogenic and anti-cancer compounds in ..
  73. Cell-type specific targting of curcumin
    BIDDANDA PONNAPPA; Fiscal Year: 2005
    ..One such dietary ingredient is curcumin, which constitutes the yellow pigment of turmeric, the spice that gives yellow color to curry...
  74. Targeting of Curcumin-genistein nanocomplexes for Treatment of Prostate Cancer
    Subhra Mohapatra; Fiscal Year: 2009
    ..goal of this proposal is to design novel treatments for prostate cancer (PCa) that employ specific targeting of curcumin and genistein nanocomplexes to PCa cells...
  75. New Approaches to Prevent or Treat Breast Cancer Metastases
    Claudia Gravekamp; Fiscal Year: 2009
    ..improvement of vaccine therapy against metastatic breast cancer by combining vaccination with the IL-6 inhibitor curcumin, using the preclinical metastatic mouse breast tumor model 4T1...
  76. Chronobiological Principles to Maximize Efficacy of Alt*
    Jack Burton; Fiscal Year: 2004
    ..evaluate chronotherapy (AIM #1) of three structurally and mechanistically distinct dietary agents, vitamin D3, curcumin and selenium (in the sodium selenite form) that have undergone preclinical and clinical trials alone or as ..
  77. PLANT ANTITUMOR AGENTS
    Kuo Hsiung Lee; Fiscal Year: 2009
    ..g., neotanshinlactone and analogs, new active constituents of Quassia gabonensis), prostate cancer actives (new curcumin analogs), and differentiation/apoptosis inducers (new water-soluble dithiophene derivatives)...