tert butylhydroperoxide

Summary

Summary: A direct-acting oxidative stress-inducing agent used to examine the effects of oxidant stress on Ca(2+)-dependent signal transduction in vascular endothelial cells. It is also used as a catalyst in polymerization reactions and to introduce peroxy groups into organic molecules.

Top Publications

  1. ncbi The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
    J J Lemasters
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, CB No 7090, 236 Taylor Hall, Chapel Hill, NC 27799 7090, USA
    Biochim Biophys Acta 1366:177-96. 1998
  2. ncbi Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)
    Mario Alía
    Departmento de Metabolismo y Nutrición, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
    J Biochem Mol Toxicol 19:119-28. 2005
  3. ncbi Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA
    Leonardo M Pérez
    Institute of Experimental Physiology, CONICET University of Rosario, Suipacha 570, 2000 Rosario, Argentina
    Free Radic Biol Med 40:2005-17. 2006
  4. ncbi Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress
    P Nicotera
    Department of Toxicology, Karolinska Institutet, Stockholm, Sweden
    Toxicology 52:55-63. 1988
  5. ncbi Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage
    Yong Pil Hwang
    College of Pharmacy, Chosun University, Gwangju, Republic of Korea
    Chem Biol Interact 181:366-76. 2009
  6. ncbi Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    Kesheng Zhao
    Departments of Pharmacology and Biochemistry, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    J Biol Chem 279:34682-90. 2004
  7. pmc Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn
    Kwan Yeop Lee
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 310 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 103:382-91. 2010
  8. pmc Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia
    K A Whyte
    School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia
    Auton Neurosci 150:45-52. 2009
  9. ncbi Alterations in phospholipid and fatty acid lipid profiles in primary neocortical cells during oxidant-induced cell injury
    Brianna Peterson
    Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602 2352, United States
    Chem Biol Interact 174:163-76. 2008
  10. ncbi Generation of free radicals during decomposition of hydroperoxide in the presence of myeloperoxidase or activated neutrophils
    O M Panasenko
    Institute of Physicochemical Medicine, Moscow, 119828, Russia
    Biochemistry (Mosc) 70:998-1004. 2005

Detail Information

Publications225 found, 100 shown here

  1. ncbi The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy
    J J Lemasters
    Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill, CB No 7090, 236 Taylor Hall, Chapel Hill, NC 27799 7090, USA
    Biochim Biophys Acta 1366:177-96. 1998
    ..A model is proposed in which onset of the MPT to increasing numbers of mitochondria within a cell leads progressively to autophagy, apoptosis and necrotic cell death...
  2. ncbi Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)
    Mario Alía
    Departmento de Metabolismo y Nutrición, Instituto del Frio, Consejo Superior de Investigaciones Cientificas, Jose Antonio Novais 10, Ciudad Universitaria, 28040 Madrid, Spain
    J Biochem Mol Toxicol 19:119-28. 2005
    ..The response of the components of the antioxidant defense system evaluated in this study indicates that tert-butyl hydroperoxide evokes a consistent cellular stress in HepG2...
  3. ncbi Oxidative stress induces actin-cytoskeletal and tight-junctional alterations in hepatocytes by a Ca2+ -dependent, PKC-mediated mechanism: protective effect of PKA
    Leonardo M Pérez
    Institute of Experimental Physiology, CONICET University of Rosario, Suipacha 570, 2000 Rosario, Argentina
    Free Radic Biol Med 40:2005-17. 2006
    ..We conclude that ROS induce hepatocellular actin-cytoskeleton rearrangement and tight-junctional impairment by a PKC-mediated, Ca2+ -dependent mechanism, which is counteracted by PKA...
  4. ncbi Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress
    P Nicotera
    Department of Toxicology, Karolinska Institutet, Stockholm, Sweden
    Toxicology 52:55-63. 1988
    ..Our findings provide further support for the hypothesis that a perturbation of intracellular Ca2+ homeostasis is an early and critical event in the development of toxicity in hepatocytes exposed to oxidative stress...
  5. ncbi Protective mechanisms of 3-caffeoyl, 4-dihydrocaffeoyl quinic acid from Salicornia herbacea against tert-butyl hydroperoxide-induced oxidative damage
    Yong Pil Hwang
    College of Pharmacy, Chosun University, Gwangju, Republic of Korea
    Chem Biol Interact 181:366-76. 2009
    ....
  6. ncbi Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury
    Kesheng Zhao
    Departments of Pharmacology and Biochemistry, Joan and Sanford I Weill Medical College of Cornell University, New York, NY 10021, USA
    J Biol Chem 279:34682-90. 2004
    ..These IMM-targeted antioxidants may be very beneficial in the treatment of aging and diseases associated with oxidative stress...
  7. pmc Involvement of reactive oxygen species in long-term potentiation in the spinal cord dorsal horn
    Kwan Yeop Lee
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 310 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 103:382-91. 2010
    ..The data suggest that elevated ROS is a downstream event of NMDA receptor activation and an essential step for potentiation of synaptic excitability in the spinal dorsal horn...
  8. pmc Reactive oxygen species modulate neuronal excitability in rat intrinsic cardiac ganglia
    K A Whyte
    School of Biomedical Sciences, University of Queensland, Brisbane QLD 4072, Australia
    Auton Neurosci 150:45-52. 2009
    ..This affects action potential duration and therefore probably modifies autonomic control of the heart during ischemia/reperfusion...
  9. ncbi Alterations in phospholipid and fatty acid lipid profiles in primary neocortical cells during oxidant-induced cell injury
    Brianna Peterson
    Department of Pharmaceutical and Biomedical Sciences, The University of Georgia, Athens, GA 30602 2352, United States
    Chem Biol Interact 174:163-76. 2008
    ..Collectively, these data identify phospholipids and fatty acids altered during oxidant treatment of neurons and suggest differential roles for Group IV and VI PLA(2) in oxidant-induced neural cell injury...
  10. ncbi Generation of free radicals during decomposition of hydroperoxide in the presence of myeloperoxidase or activated neutrophils
    O M Panasenko
    Institute of Physicochemical Medicine, Moscow, 119828, Russia
    Biochemistry (Mosc) 70:998-1004. 2005
    ....
  11. ncbi Inhibition of tert-butyl hydroperoxide-induced cell membrane bleb formation by alpha-tocopherol and glutathione
    H W Chen
    Department of Nutrition, Chung Shan Medical College, 40203, Taichung, Taiwan
    Food Chem Toxicol 38:1089-96. 2000
    ..These results indicated that intracellular GSH and alpha-tocopherol status are important to the TBH-induced cell membrane abnormality. Furthermore, TS plays a defensive role against blebbing when GSH is exhausted by TBH...
  12. ncbi The effect of tertiary butylhydroperoxide and nicotinamide on human cortical neurons
    Manisha Sonee
    Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, 57007, Brookings, SD, USA
    Neurotoxicology 24:443-8. 2003
    ..However nicotinamide did not seem to alter bcl-2 levels. These results indicate that nicotinamide treatment can protect human neuronal cells from the toxic effects of t-BuOOH...
  13. ncbi Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress
    Ranieri Rossi
    Department of Neuroscience, Pharmacology Section, University of Siena, Siena, Italy
    Clin Chem 52:1406-14. 2006
    ..We evaluated the importance of correct sample handling during the preanalytical phase for GSH, GSSG, and PSSG measurement...
  14. ncbi Membrane cholesterol contents influence the protective effects of quercetin and rutin in erythrocytes damaged by oxidative stress
    Abel López-Revuelta
    Departamento de Bioquimica y Biologia Molecular, Universidad de Salamanca, Plaza Doctores de la Reina s n, 37007 Salamanca, Spain
    Chem Biol Interact 161:79-91. 2006
    ....
  15. ncbi Anthocyanins protect against DNA damage induced by tert-butyl-hydroperoxide in rat smooth muscle and hepatoma cells
    M C Lazzè
    Dipartimento di Medicina Sperimentale, Sezione di Patologia Generale C Golgi, Universita di Pavia, Piazza Botta 10, 27100 Pavia, Italy
    Mutat Res 535:103-15. 2003
    ..The different activity of anthocyanins and their derivatives may be explained taking into account a structure/function relationship that could also influence anthocyanin intracellular localisation...
  16. ncbi Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells
    Ji Eun Park
    Department of Biochemistry, College of Natural Sciences, Kyungpook National University, Taegu 702 701, Republic of Korea
    Biochimie 84:1199-205. 2002
    ..The results indicate that the peroxidation of lipid is probably one of the important intermediary events in oxidative stress-induced cellular damage...
  17. ncbi Preventive effect of trimidox on oxidative stress in U937 cell line
    Syu ichi Kanno
    Department of Clinical Pharmacotherapeutics, Tohoku Pharmaceutical University, Sendai, Japan
    Biol Pharm Bull 30:994-8. 2007
    ....
  18. ncbi An aqueous extract of Rubus chingii fruits protects primary rat hepatocytes against tert-butyl hydroperoxide induced oxidative stress
    Ming Hon Yau
    Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, China
    Life Sci 72:329-38. 2002
    ..These results suggested that Fructus Rubi was useful in protecting against t-BHP-induced oxidative damage and may also be capable of attenuating cytotoxicity of other oxidants...
  19. ncbi Hydrogen peroxide mediates higher order chromatin degradation
    H Bai
    Department of Neurobiology and Anatomy, West Virginia University School of Medicine, 4052 HSN, P O Box 9128, Morgantown, WV 26506 9128, USA
    Neurochem Int 42:123-9. 2003
    ....
  20. ncbi Protective effect of aqueous extract of Perilla frutescens on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats
    Min Kyung Kim
    Department of Food Science, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Food Chem Toxicol 45:1738-44. 2007
    ..Based on the results described above, it is suggested that PLE has the potential to protect liver against t-BHP-induced hepatic damage in rats...
  21. ncbi Complementary antioxidant defense by cytoplasmic and mitochondrial peroxiredoxins in Leishmania infantum
    Helena Castro
    Institute for Molecular and Cell Biology, Porto, Portugal
    Free Radic Biol Med 33:1552-62. 2002
    ..The results show evidence that both enzymes are active as peroxidases in vivo and that they have complementary roles in parasite protection against oxidative stress...
  22. ncbi Effect of the olive oil phenol hydroxytyrosol on human hepatoma HepG2 cells. Protection against oxidative stress induced by tert-butylhydroperoxide
    Luis Goya
    Depto de Metabolismo y Nutrición, Instituto del Frio CSIC, C Jose Antonio Novais, 10 Ciudad Universitaria, 28040 Madrid, Spain
    Eur J Nutr 46:70-8. 2007
    ....
  23. pmc Oxidant-induced inhibition of myocardial calcium-independent phospholipase A2
    J McHowat
    Department of Pathology, Saint Louis University School of Medicine, St. Louis, MO 63104, USA
    Cardiovasc Toxicol 1:309-16. 2001
    ..This conclusion was further validated by the experiments in which pretreatment with the calcium-independent phospholipase A2 inhibitor bromoenol lactone exacerbated cardiotoxicity of tert-butyl hydroperoxide in myocyte cultures...
  24. ncbi Membrane depolarization of isolated rat liver mitochondria attenuates permeability transition pore opening and oxidant production
    Anna Aronis
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Antioxid Redox Signal 4:647-54. 2002
    ..FCCP also decreased the augmented ROS production induced by inorganic phosphate. It is concluded that mitochondrial depolarization protects and prevents high-amplitude swelling and PT-derived ROS production...
  25. ncbi Sustained versus transient ERK1/2 signaling underlies the anti- and proapoptotic effects of oxidative stress in human RPE cells
    Anne Lise Glotin
    Institut Biomedical des Cordeliers, INSERM Institut National de la Santé et de la Recherche Médicale Unité 598, Paris, France
    Invest Ophthalmol Vis Sci 47:4614-23. 2006
    ..This study was conducted to investigate the involvement of the MAP kinase pathways during the induction of RPE cell death by oxidative stress...
  26. ncbi Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent
    Kasey C Nelson
    Departments of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 43:3550-4. 2002
    ..To determine whether oltipraz (4-methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione) protects against oxidative injury in cultured human retinal pigment epithelial (hRPE) cells...
  27. ncbi Hypochlorous acid-induced oxidative damage of human red blood cells: effects of tert-butyl hydroperoxide and nitrite on the HOCl reaction with erythrocytes
    Ilya B Zavodnik
    Institute of Biochemistry Academy of Sciences of Belarus, 230017 Grodno, Belarus
    Bioelectrochemistry 58:127-35. 2002
    ..The presence of other oxidants, nitrite or tert-butyl hydroperoxide (t-BHP), promoted the oxidative damage induced by HOCl and led to new oxidative reactions...
  28. ncbi Modulatory effects of resveratrol, citroflavan-3-ol, and plant-derived extracts on oxidative stress in U937 cells
    Nora M O'Brien
    Department of Food and Nutritional Sciences, University College Cork, Cork, Republic of Ireland
    J Med Food 9:187-95. 2006
    ....
  29. ncbi Nonezymatic formation of succinate in mitochondria under oxidative stress
    Nadezhda I Fedotcheva
    Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region 142290, Russia
    Free Radic Biol Med 41:56-64. 2006
    ..Thus, upon oxidative stress, nonenzymatic decarboxylation of KGL and transamination switch the TCA cycle to the formation and oxidation of succinate...
  30. ncbi Optimisation of cell-based assays for medium throughput screening of oxidative stress
    S Lautraite
    Bayer CropScience, 355 rue Dostoïevski BP 153 06903 Sophia Antipolis cedex, France
    Toxicol In Vitro 17:207-20. 2003
    ..It should also be of interest for retrospective and explanatory studies of mechanisms underlying toxicity observed in vivo...
  31. ncbi Flavonoids protect U-937 macrophages against tert-butylhydroperoxide induced oxidative injury
    - Kanupriya
    Defence Institute of Physiology and Allied Sciences, Lucknow Road, Timarpur, Delhi 110054, India
    Food Chem Toxicol 44:1024-30. 2006
    ..Epicatechin and catechin were found to be more efficient than quercetin in inhibiting tert-BOOH induced cellular damage...
  32. ncbi Role of glutathione in the induction of apoptosis and c-fos and c-jun mRNAs by oxidative stress in tumor cells
    Carmen Tormos
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universitat de Valencia, Avda Blasco Ibanez 17, 46010 Valencia, Spain
    Cancer Lett 208:103-13. 2004
    ....
  33. ncbi Inactivation of endoplasmic reticulum bound Ca2+-independent phospholipase A2 in renal cells during oxidative stress
    Brian S Cummings
    Department of Pharmaceutical Sciences, Division of Nephrology, Medical University of South Carolina, 280 Calhoun Street, Charleston, SC 29425, USA
    J Am Soc Nephrol 15:1441-51. 2004
    ....
  34. ncbi Commonly consumed and naturally occurring dietary substances affect biomarkers of oxidative stress and DNA damage in healthy rats
    E O Farombi
    Danish Institute for Food and Veterinary Research, Mørkhøj Bygade 19, DK 2860 Søborg, Denmark
    Food Chem Toxicol 42:1315-22. 2004
    ....
  35. ncbi Oxidative stress stimulates the synthesis of the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid by inflammatory cells
    Karl Rudolf Erlemann
    Meakins Christie Laboratories, Department of Medicine, McGill University, Montreal, Quebec H2X 2P2, Canada
    J Biol Chem 279:40376-84. 2004
    ..Oxidative stress could be an important mechanism for stimulating 5-oxo-ETE production in inflammation, promoting further infiltration of granulocytes into inflammatory sites...
  36. ncbi Effect of aminoethylcysteine ketimine decarboxylated dimer, a natural sulfur compound present in human plasma, on tert-butyl hydroperoxide-induced oxidative stress in human monocytic U937 cells
    Alberto Macone
    Department of Biochemical Sciences A Rossi Fanelli, University of Rome La Sapienza, Rome 00185, Italy
    Free Radic Res 38:705-14. 2004
    ..Due to its presence in both human plasma and urine, AECK-DD may play a role in the modulation of oxidative processes in vivo...
  37. ncbi Sensitivity of dark mutants of various strains of luminescent bacteria to reactive oxygen species
    Robert Lyzeń
    Department of Molecular Biology, University of Gdansk, Kładki 24, 80 822 Gdansk, Poland
    Arch Microbiol 183:203-8. 2005
    ..These results support the hypotheses that (1) activities of bacterial luciferases may detoxify deleterious oxygen derivatives, and (2) significantly different efficiencies of this reaction are characteristic for various luciferases...
  38. ncbi Transgenic mice overexpressing glutathione peroxidase 4 are protected against oxidative stress-induced apoptosis
    Qitao Ran
    Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, 7400 Merton Mintor Boulevard, San Antonio, TX 78229, USA
    J Biol Chem 279:55137-46. 2004
    ..These data demonstrate that Gpx4 plays a role in vivo in the mechanism of apoptosis induced by oxidative stress that most likely occurs through oxidative damage to mitochondrial phospholipids such as cardiolipin...
  39. ncbi Apoptotic and necrotic mechanisms of stress-induced human lens epithelial cell death
    Amy C Long
    OSU Interdisciplinary PhD Program in Nutrition, The Ohio State University, Columbus, OH 43210, USA
    Exp Biol Med (Maywood) 229:1072-80. 2004
    ..These findings suggest UVB predominantly induces apoptosis in HLE cells, whereas H(2)O(2) and TBHP induce necrosis...
  40. ncbi Protective effect of saponins derived from roots of Platycodon grandiflorum on tert-butyl hydroperoxide-induced oxidative hepatotoxicity
    Kyung Jin Lee
    Department of Pharmacy, College of Pharmacy, Chosun University, 375 Seosuk dong, Kwangju 501 759, South Korea
    Toxicol Lett 147:271-82. 2004
    ..These results support the anti-oxidative role of CKS, and demonstrate that CKS can scavenge oxygen free radicals and protect cells from oxidative stress...
  41. ncbi Protective effects of baicalein on tert-butyl hydroperoxide-induced hepatic toxicity in rat hepatocytes
    Jin Ming Hwang
    Institute of Medicine, Medical College, Chung Shan Medical University, Taichung, 402, Taiwan
    J Biomed Sci 12:389-97. 2005
    ..The sum of the results suggests that the protective effect of baicalein against the cytotoxicity and genotoxicity of hepatocytes induced by t-BHP is due to its ability to quench free radicals...
  42. ncbi Retrovirally mediated overexpression of peroxiredoxin VI increases the survival of WI-38 human diploid fibroblasts exposed to cytotoxic doses of tert-butylhydroperoxide and UVB
    Jean Francois Dierick
    Unit of Research on Cellular Biology, University of Namur FUNDP, Rue de Bruxelles 61, B 5000 Namur, Belgium
    Biogerontology 4:125-31. 2003
    ..No protection was found against ethanol- or H(2)O(2)-caused cytotoxicity. These effects are correlated with the known functions of Prx VI...
  43. ncbi t-BOOH-induced oxidative damage in sickle red blood cells and the role of flavonoids
    M Cesquini
    Departamento de Bioquimica, Instituto de Biologia, Universidade Estadual de Campinas UNICAMP, CP 6109, CEP 13083 970, Campinas, SP, Brazil
    Biomed Pharmacother 57:124-9. 2003
    ..This synergistic action helped to maintain a constant supply of flavonoids and thus, rescue the cells from the injury caused by free radicals and iron ions...
  44. ncbi Oxidative stimuli affect polyglutamine aggregation and cell death in human mutant ataxin-1-expressing cells
    Sung Jo Kim
    Laboratory of Molecular Genetics, Graduate School of Biotechnology, Korea University, Seoul 136 701, South Korea
    Neurosci Lett 348:21-4. 2003
    ..Our results might give insight into the mechanism whereby polyglutamine proteins aggregate and suggest that treatment of appropriate antioxidant reagents might prevent progression of SCA1 and other polyglutamine diseases...
  45. ncbi Protective effects of ellagic and chlorogenic acids against oxidative stress in PC12 cells
    Sanja Pavlica
    Institut fur Biochemie, Medizinische Fakultat, Universitat Leipzig, Liebigstr 16, Leipzig, 04103, Germany
    Free Radic Res 39:1377-90. 2005
    ..These findings suggest that two dietary antioxidants, EA and CGA, may have protective properties against oxidative stress induced in CNS...
  46. ncbi Protective effects of hyperoside (quercetin-3-o-galactoside) to PC12 cells against cytotoxicity induced by hydrogen peroxide and tert-butyl hydroperoxide
    Zhiyong Liu
    State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, 200237Meilong Road 130, Box 311, Shanghai, PR China
    Biomed Pharmacother 59:481-90. 2005
    ..All the above results showed hyperoside could efficiently prevent the PC12 cells from shrinking and turning against apoptosis induced by hydrogen peroxide and tert-butyl hydroperoxide...
  47. pmc (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage
    Ludmila A Voloboueva
    Biophysics Graduate Group, University of California, Berkeley, USA
    Invest Ophthalmol Vis Sci 46:4302-10. 2005
    ..To determine whether (R)-alpha-lipoic acid (LA) protects cultured human fetal retinal pigment epithelial (hfRPE) cells against oxidative injury and identify the pathways that may mediate protection...
  48. ncbi Quercetin protects human hepatoma HepG2 against oxidative stress induced by tert-butyl hydroperoxide
    Mario Alía
    Departamento de Metabolismo y Nutricion, Instituto del Frio CSIC, C Jose Antonio Novais, 10, Ciudad Universitaria, 28040 Madrid, Spain
    Toxicol Appl Pharmacol 212:110-8. 2006
    ..The results of the biomarkers analyzed clearly show that treatment of HepG2 cells in culture with the natural dietary antioxidant quercetin strongly protects the cells against an oxidative insult...
  49. ncbi Apolipoprotein A-IV attenuates oxidant-induced apoptosis in mitotic competent, undifferentiated cells by modulating intracellular glutathione redox balance
    Heather L Spaulding
    Dept of Surgery, Louisiana State Univ Health Sciences Center, 1501 Kings Highway, Shreveport, LA 71130, USA
    Am J Physiol Cell Physiol 290:C95-C103. 2006
    ..These results suggest a novel role for Apo A-IV in the regulation of intracellular glutathione redox balance and the modulation of redox-dependent apoptosis via stimulation of G6PD activity...
  50. ncbi Activation of cyclooxygenases by H2O2 and t-butylhydroperoxide in aged rat lung
    Jee Won Im
    Department of Pharmacy, Pusan National University, Busan, Korea
    Biotechnol Lett 26:1665-9. 2004
    ..Our results suggested that COX activators such as t-BHP and H2O2, which are located in cytosol, are essential for the activation of COX in aged lung...
  51. ncbi Density-dependent expression of FGF-2 in response to oxidative stress in RPE cells in vitro
    M Wada
    Department of Ophthalmology, University of California, Davis, CA 95616, USA
    Curr Eye Res 23:226-31. 2001
    ..CONCLUSIONS: These results suggest that care should be taken to control for cell density in similar types of in vitro experiments...
  52. ncbi Selenium methylselenocysteine protects human hepatoma HepG2 cells against oxidative stress induced by tert-butyl hydroperoxide
    Susana Cuello
    Departamento de Quimica Analitica, Facultad de Quimicas, Universidad Complutense, 28040, Madrid, Spain
    Anal Bioanal Chem 389:2167-78. 2007
    ..The results show that treatment of HepG2 cells with concentrations of Se-MeSeCys in the nanomolar to micromolar range confers a significant protection against an oxidative insult...
  53. ncbi Oxidative insult in sheep red blood cells induced by T-butyl hydroperoxide: the roles of glutathione and glutathione peroxidase
    C G Zou
    School of Biological Sciences, University of New England, Armidale, NSW, Australia
    Free Radic Res 34:45-56. 2001
    ....
  54. ncbi Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes
    M L Dubuisson
    , Croix du Sud, 4-5; B-1348 Louvain-la-Neuve, Belgium
    Free Radic Res 34:285-96. 2001
    ....
  55. ncbi Protection of primary glial cells by grape seed proanthocyanidin extract against nitrosative/oxidative stress
    S Roychowdhury
    Otto-von-Guericke University, Institute for Medical Neurobiology, Leipziger Strasse 44, Magdeburg, D-39120, Germany
    Nitric Oxide 5:137-49. 2001
    ..Furthermore, GSPE pretreatment protects the microglial GSH pool during high output NO production and results in an elevation of the H(2)O(2) tolerance in astroglial cells...
  56. ncbi Protection against oxidant-induced apoptosis by exogenous glutathione in Leber hereditary optic neuropathy cybrids
    Anna Ghelli
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Bologna, Italy
    Invest Ophthalmol Vis Sci 49:671-6. 2008
    ..To use different paradigms of oxidative and metabolic stress in a cellular model of Leber hereditary optic neuropathy (LHON), with the aim of evaluating the efficacy of potentially therapeutic molecules for the treatment of this disease...
  57. ncbi Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis
    H Van Remmen
    Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78284, USA
    Am J Physiol Heart Circ Physiol 281:H1422-32. 2001
    ..These experiments demonstrate that MnSOD may play an important role in the induction of the mitochondrial pathway of apoptosis in the heart, and this appears to occur primarily through the permeability transition...
  58. ncbi Upregulation of AP1 by tertiary butyl hydroperoxide induced oxidative stress and subsequent effect on spermatogenesis in mice testis
    Parminder Kaur
    Department of Biophysics, Panjab University, Chandigarh 160014, India
    Mol Cell Biochem 308:177-81. 2008
    ..001). These results suggest a potential role of AP1 in oxidative stress-mediated meiotic and post meiotic changes in the spermatogenic process and regulation of cell number in male reproductive system...
  59. ncbi Peroxide-induced cell death and lipid peroxidation in C6 glioma cells
    Arne Linden
    Institute for Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse 10, 24105 Kiel, Germany
    Toxicol In Vitro 22:1371-6. 2008
    ..The results strongly indicate a major role of lipid peroxidation in the killing of C6 cells by organic peroxides but also that lipid peroxidation is not involved in H2O2 induced cell death...
  60. ncbi The molecular basis of oxidative stress-induced cell death in an immortalized retinal ganglion cell line
    Pamela Maher
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA, USA
    Invest Ophthalmol Vis Sci 46:749-57. 2005
    ..To characterize the molecular basis of oxidative stress-induced death, a process that has been implicated in several chronic eye diseases, in RGC-5 cells, an immortalized retinal ganglion cell (RGC) line...
  61. ncbi Flavonoids protect retinal ganglion cells from oxidative stress-induced death
    Pamela Maher
    Salk Institute, La Jolla, California 92037, USA
    Invest Ophthalmol Vis Sci 46:4796-803. 2005
    ..The purpose of this study was to determine whether flavonoids, natural products that are abundant in fruits and vegetables, can protect retinal ganglion cells from oxidative stress-induced death...
  62. ncbi Demonstration by redox fluorometry that sulforaphane protects retinal pigment epithelial cells against oxidative stress
    Marisol del V Cano
    Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Invest Ophthalmol Vis Sci 49:2606-12. 2008
    ....
  63. ncbi Macelignan protects HepG2 cells against tert-butylhydroperoxide-induced oxidative damage
    Jong Hee Sohn
    Department of Biotechnology, Yonsei University, Seoul, Korea
    Biofactors 29:1-10. 2007
    ..These results strongly suggest that macelignan has significant protective ability against oxidative damage caused by reactive intermediates...
  64. ncbi Dimerumic acid protected oxidative stress-induced cytotoxicity in isolated rat hepatocytes
    Jun ichi Yamashiro
    Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
    Cell Biol Toxicol 24:283-90. 2008
    ..Thus, DMA showed an antioxidative effect in hepatocytes and protected against hepatotoxicity by suppressing oxidative stress without affecting CYP enzymes...
  65. ncbi Inhibition of aconitase by alloxan and the differential modes of protection of glucose, 3-O-methylglucose, and mannoheptulose
    S Lenzen
    Institute of Pharmacology and Toxicology, University of Gottingen, Federal Republic of Germany
    Naunyn Schmiedebergs Arch Pharmacol 346:532-6. 1992
    ..In the light of these results the unique protective potency of glucose as compared to that of other sugars is not surprising...
  66. ncbi The quantitative characterization of free radical sources and traps by electromigration applications
    Gabriella Donáth-Nagy
    University of Medicine and Pharmacy from Targu Mures, Romania
    J Biochem Biophys Methods 70:1317-23. 2008
    ..This method is based on measure of the catalytic polarografic current of Fe(III) in the presence of free radical sources (TBH, hydrogen-peroxydes), and their traps. Personal contribution of the authors in this field is discussed...
  67. ncbi Suppression of radical-induced lipid peroxidation in a model system by alkyl esters of cinnamate quaternary ammonium salts
    A Krasowska
    Institute of Microbiology, University of Wroclaw, Poland
    Z Naturforsch C 56:878-85. 2001
    ..PPA-n class antioxidants have the lowest critical micelle concentration, which may limit their efficiency. Nevertheless, these phenolic antioxidants can be conveniently employed as highly efficient inhibitors of lipid peroxidation...
  68. ncbi Mangifera indica L. extract (Vimang) inhibits Fe2+-citrate-induced lipoperoxidation in isolated rat liver mitochondria
    Gilberto Pardo Andreu
    Departamento de Patologia Clinica, Faculdade de Ciencias Medicas, Universidade Estadual de Campinas 13083 970 Campinas, SP, Brasil
    Pharmacol Res 51:427-35. 2005
    ..These results are of pharmacological relevance since Vimang could be a potential candidate for antioxidant therapy in diseases related to abnormal intracellular iron distribution or iron overload...
  69. ncbi Mechanism of protection by the flavonoids, quercetin and rutin, against tert-butylhydroperoxide- and menadione-induced DNA single strand breaks in Caco-2 cells
    S A Aherne
    Nutritional Sciences, Department of Food Science and Technology, National University of Ireland, Cork, Ireland
    Free Radic Biol Med 29:507-14. 2000
    ..However, quercetin, and not rutin, protected against menadione-induced DNA single strand breaks by acting as both a metal chelator and radical scavenger...
  70. ncbi Leukocyte adhesion after oxidant challenge in the hamster cheek pouch microcirculation
    E Bouskela
    Laboratório de Pesquisas em Microcirculação, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil
    J Vasc Res 36:11-4. 1999
    ..001). The inhibition of oxidant-induced leukocyte adhesion by S-5682 was similar to that seen for ischemia-reperfusion and the higher dose of S-5682 was as effective as alpha-tocopherol in inhibiting it...
  71. ncbi Nonheme iron in sickle erythrocyte membranes: association with phospholipids and potential role in lipid peroxidation
    S A Kuross
    Department of Medicine, University of Minnesota Medical School, Minneapolis
    Blood 72:1278-85. 1988
    ..These data provide additional support for the concept that iron decompartmentalization is a characteristic of sickle RBCs...
  72. ncbi Protein methylation as a marker of aspartate damage in glucose-6-phosphate dehydrogenase-deficient erythrocytes: role of oxidative stress
    Diego Ingrosso
    Department of Biochemistry and Biophysics, School of Medicine, Second University of Naples, Italy
    Eur J Biochem 269:2032-9. 2002
    ....
  73. ncbi Proteinases in renal cell death
    X Yang
    Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, USA
    J Toxicol Environ Health 48:319-32. 1996
    ..The observation that E-64 was only protective after some cell death had occurred suggests that lysosomal cathepsins are released from dying cells and subsequently attack the remaining viable cells...
  74. ncbi Permeability transition in rat liver mitochondria is modulated by the ATP-Mg/Pi carrier
    Thilo Hagen
    Wolfson Institute for Biomedical Research, University College London, United Kingdom
    Am J Physiol Gastrointest Liver Physiol 285:G274-81. 2003
    ....
  75. ncbi Effect of endoplasmic reticulum stress preconditioning on cytotoxicity of clinically relevant nephrotoxins in renal cell lines
    Mathieu Peyrou
    Biomedical Sciences, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, Canada C1A 4P3
    Toxicol In Vitro 21:878-86. 2007
    ..These results support the hypothesis that ER is involved in drug-induced renal toxicity...
  76. ncbi Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes--reversal with (R)-alpha-lipoic acid supplementation
    J Lykkesfeldt
    Department of Molecular and Cell Biology, University of California at Berkeley, 94720, USA
    FASEB J 12:1183-9. 1998
    ..These results provide further evidence for the potential of alpha-lipoic acid in treatment of diseases related to oxidative stress. Furthermore, the study extends the value of ascorbic acid as a biomarker of oxidative stress...
  77. ncbi Effects of ascorbate on membrane phospholipids and tocopherols of intact erythrocytes during peroxidation by t-butylhydroperoxide: comparison with effects of dithiothreitol
    S Mawatari
    Department of Nutrition and Health Science, Faculty of Human Environmental Science, Fukuoka Women s University, Japan
    Lipids 36:57-65. 2001
    ..On the other hand, dithiothreitol (DTT) (5 mM) almost completely prevented the formation of metHB, and DTT completely protected the PL and Toc against peroxidation, indicating the importance of sulfhydryl groups in erythrocytes...
  78. pmc Translocation of iron from lysosomes into mitochondria is a key event during oxidative stress-induced hepatocellular injury
    Akira Uchiyama
    Department of Pharmaceutical and Biomedical Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Hepatology 48:1644-54. 2008
    ....
  79. ncbi Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells
    M Arai
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108, Japan
    J Biol Chem 274:4924-33. 1999
    ....
  80. pmc Glucose regulation of hydroperoxide metabolism in rat intestinal cells. Stimulation of reduced nicotinamide adenine dinucleotide phosphate supply
    T Y Aw
    Department of Physiology and Biophysics, Louisiana State University Medical Center, Shreveport 71130
    J Clin Invest 94:2426-34. 1994
    ..This responsiveness to glucose suggests that nutrient availability would be an important contributing factor in the detoxication of toxic hydroperoxides by the small intestine...
  81. ncbi Hepatoprotective activity of polyhydroxylated 2-styrylchromones against tert-butylhydroperoxide induced toxicity in freshly isolated rat hepatocytes
    Eduarda Fernandes
    REQUIMTE, Toxicology Department, Faculty of Pharmacy, University of Porto, Rua Anibal Cunha 164, 4050 047, Porto, Portugal
    Arch Toxicol 77:500-5. 2003
    ..125, 12.5, 25, and 50 microM, prevented the t-BHP induced glutathione depletion, lipid peroxidation, and cell death in freshly isolated rat hepatocytes to a comparable potency with that of quercetin...
  82. ncbi Mitochondrial phospholipase A2 activated by reactive oxygen species in heart mitochondria induces mild uncoupling
    J Jezek
    Department of Membrane Transport Biophysics, No 75, Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Physiol Res 59:737-47. 2010
    ..In conclusion, ROS-induced function of cardiac mt-iPLA2 may stand on a pro-survival side of ischemia-reperfusion injury...
  83. ncbi Arabidopsis thaliana NADPH oxidoreductase homologs confer tolerance of yeasts toward the thiol-oxidizing drug diamide
    E Babiychuk
    Laboratorium voor Genetica, Universiteit Gent, Belgium
    J Biol Chem 270:26224-31. 1995
    ..The data suggested that proteins encoded by the isolated cDNAs play a distinct role in plant antioxidant defense and are possibly involved in NAD(P)/NAD(P)H homeostasis...
  84. ncbi Dose-related inversion of cinnarizine and flunarizine effects on mitochondrial permeability transition
    A Elimadi
    Departement de Pharmacologie, Faculté de Médecine de Paris XII, IM3, Creteil, France
    Eur J Pharmacol 348:115-21. 1998
    ....
  85. ncbi Oxidative stress, thiol reagents, and membrane potential modulate the mitochondrial permeability transition by affecting nucleotide binding to the adenine nucleotide translocase
    A P Halestrap
    Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Biol Chem 272:3346-54. 1997
    ..Both mechanisms act to decrease the Ca2+ sensitivity of the pore. Thiol reagents and oxidative stress may modify two thiol groups on the ANT and thus stimulate pore opening by both means...
  86. ncbi 13C and 31P NMR studies of glucose and 2-deoxyglucose metabolism in normal and enzyme-deficient human erythrocytes
    A Ferretti
    Laboratorio di Biologia Cellulare, Istituto Superiore di Sanita, Rome, Italy
    Clin Chim Acta 208:39-61. 1992
    ..Faster consumption of either glucose or 2-deoxyglucose is induced, only in normal cells, by treatment with tert-butylhydroperoxide, essentially as a consequence of the activation of the pentose-phosphate pathway...
  87. ncbi Identification of platelet-activating factor acetylhydrolase II in human skin
    Mariangela Marques
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana 46202, U S A
    J Invest Dermatol 119:913-9. 2002
    ....
  88. ncbi In vitro and in vivo characterization of alkyl hydroperoxide reductase mutant strains of Helicobacter hepaticus
    Nalini S Mehta
    Department of Microbiology, University of Georgia, Athens, GA 30602, USA
    Biochim Biophys Acta 1770:257-65. 2007
    ..The use of erythromycin resistance insertion as a facile way to screen for gene-targeted mutants, and the chromosomal complementation of those mutants are new genetic procedures for studying H. hepaticus...
  89. ncbi Cytosolic thioredoxin peroxidase I and II are important defenses of yeast against organic hydroperoxide insult: catalases and peroxiredoxins cooperate in the decomposition of H2O2 by yeast
    Daniela Cristina Munhoz
    Departamento de Biologia, Instituto de Biociencias, USP, 05508 900, Sao Paulo, Brazil
    J Biol Chem 279:35219-27. 2004
    ..In regard to the stress induced by H(2)O(2), catalases (peroxisomal and/or cytosolic) and cTPxII seemed to cooperate with cTPxI in the defense of yeast against this oxidant...
  90. ncbi [Reactive oxygen forms and luminescence of intact microspore cells]
    V V Roshchina
    Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia
    Biofizika 48:259-64. 2003
    ..It was shown that the formation of ROS contributes to the luminescence of plant microspores, which reflects their functional state...
  91. ncbi Parenteral multivitamin supplementation induces both oxidant and antioxidant responses in the liver of newborn guinea pigs
    P Chessex
    Perinatal Service and Research Center, H pital Ste Justine, University of Montreal, Quebec, Canada
    J Pediatr Gastroenterol Nutr 32:316-21. 2001
    ..The aim of this study was to determine whether the parenteral multivitamin preparation induces in the liver a peroxide-induced oxidant challenge or an antioxidant protection associated with the antiradical components of the solution...
  92. ncbi Hepatocytes from metallothionein-I and II knock-out mice are sensitive to cadmium- and tert-butylhydroperoxide-induced cytotoxicity
    H Zheng
    Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160 7417, USA
    Toxicol Lett 87:139-45. 1996
    ..5-2.0 mM), suggesting that MT does not protect against MNNG-induced cytotoxicity. These results support the hypothesis that constitutive MT levels affect the sensitivity of mammalian cells to Cd and oxidative stress...
  93. ncbi Protective effect of diosmetin on in vitro cell membrane damage and oxidative stress in cultured rat hepatocytes
    P Villa
    C N R National Research Council Center of Cytopharmacology, Department of Pharmacology, Milan, Italy
    Toxicology 73:179-89. 1992
    ..After 40 h exposure to both flavonoids diosmin but not diosmetin was detectable in the cell membrane fraction, suggesting that the latter's protective effect is associated with its metabolites...
  94. ncbi Catalase takes part in rat liver mitochondria oxidative stress defense
    Mauro Salvi
    Dipartimento di Chimica Biologica, Universita di Padova, Viale G Colombo 3, 35121 Padova
    J Biol Chem 282:24407-15. 2007
    ....
  95. pmc Mechanism of metal-independent decomposition of organic hydroperoxides and formation of alkoxyl radicals by halogenated quinones
    Ben Zhan Zhu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People s Republic of China
    Proc Natl Acad Sci U S A 104:3698-702. 2007
    ..This represents a mechanism of organic alkoxyl radical formation not requiring the involvement of redox-active transition metal ions...
  96. ncbi Catalase vs peroxidase activity of a manganese(II) compound: identification of a Mn(III)-(mu-O)(2)-Mn(IV) reaction intermediate by electrospray ionization mass spectrometry and electron paramagnetic resonance spectroscopy
    Josane A Lessa
    Laboratorio de Ciencias Quimicas, Universidade Estadual do Norte Fluminense, 28013 602, Campos dos Goytacazes, RJ, Brazil
    Inorg Chem 48:4569-79. 2009
    ..A mechanistic model for the catalase activity of 1 that incorporates the observed lag phase in O(2) production, the pH variation, and the formation of a Mn(III)-(mu-O)(2)-Mn(IV) intermediate is proposed...
  97. ncbi Protective effect of flavonoids on drug-induced hepatotoxicity in vitro
    J C Davila
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin 78712
    Toxicology 57:267-86. 1989
    ..The results of this study suggest that CAT and SIL may act by stabilizing the plasma membrane against toxic insult...
  98. ncbi Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver
    Yong Wu
    Department of Pathology, Harbor University of California Los Angeles Research and Education Institute, Torrance, USA
    Mol Pharmacol 65:550-7. 2004
    ..Regulation of hepatic GSH levels by RXRalpha is essential to protect hepatocytes from oxidative stress, whereas up-regulation of phase I drug metabolism genes by RXRalpha may render the liver more sensitive to APAP-induced toxicity...
  99. ncbi Reduced Ca2+ entry and suicidal death of erythrocytes in PDK1 hypomorphic mice
    Michael Foller
    Department of Physiology, University of Tuebingen, Gmelinstr 5, 72076 Tubingen, Germany
    Pflugers Arch 455:939-49. 2008
    ..The experiments reveal that PDK1 deficiency is associated with decreased Ca2+ entry into erythrocytes and thus with blunted eryptotic effects of oxidative stress, osmotic shock and Cl- removal...
  100. ncbi Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol
    Brad L Upham
    Department of Pediatrics and Human Development and the National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824 1302, USA
    Nutr Cancer 57:38-47. 2007
    ..NAC did not prevent any of the peroxide effects on either GJIC or extracellular receptor kinase, suggesting a specific antioxidant effect of resveratrol...
  101. pmc Divergent light-, ascorbate-, and oxidative stress-dependent regulation of expression of the peroxiredoxin gene family in Arabidopsis
    Frank Horling
    Department of Plant Physiology and Biochemistry W5, University of Bielefeld, 33501 Bielefeld, Germany
    Plant Physiol 131:317-25. 2003
    ..The results are discussed in context with the subcellular localization of the Prx gene products...

Research Grants21

  1. CALCIUM & CALPAINS IN TOXICANT INDUCED RENAL CELL DEATH
    RICK SCHNELLMANN; Fiscal Year: 2000
    ..Determining the mechanisms of action of a number of known cytoprotectants from diverse chemical classes may ultimately result in the identification of new pharmacological agents that prevent cell death and organ failure. ..
  2. FATE OF TOXIC CHEMICALS IN HEPATOCYTE AND HEPATOMA CELLS
    Michael Meredith; Fiscal Year: 1992
    ..7) Investigate the regulation of Gamma-cystathionase activity in rat hepatocytes before and after GSH depletion. 8) Examine the thiol status of human hepatocytes and evaluate the importance of the mitochondrial GSH pool...
  3. GENISTEIN AS MODULATOR OF ANTIOXIDANT PROTEIN EXPRESSION
    Shiu Ming Kuo; Fiscal Year: 2002
    ..These studies may also lead to the identification of a previous unknown pathway for Gn to regulate mammalian genes. ..
  4. Enhanced Killing of Cancer Cell by Sulindac and Oxidative Stress
    Herbert Weissbach; Fiscal Year: 2007
    ..We will contribute the understanding of the mechanism that lead to cancer cells death by the NSAID Sulindac and its derivatives. PHS 398/2590 (Rev. 09/04) Page Continuation Format Page [unreadable] [unreadable] [unreadable]..
  5. MITOCHONDRIAL FUNCTION IN OXIDATIVE INJURY
    Anna Liisa Nieminen; Fiscal Year: 1999
    ..The project will provide fundamental new information concerning mechanisms underlying cell death resulting from oxidative injury. ..
  6. MECHANISM OF RENAL CELL REPAIR FOLLOWING TOXICANT INJURY
    RICK SCHNELLMANN; Fiscal Year: 2002
    ..Completion of these aims will result in a better understanding of the mechanisms involved in renal cell regeneration and the repair of physiological functions following toxicant exposure. ..
  7. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  8. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  9. Erythrocytes, immuno-modulation and G6PD deficiency
    Zoltan Spolarics; Fiscal Year: 2007
    ..Elucidation of macrophage and T-cell cytokine responses to infection in G6PD deficiency may also be important in providing a mechanism of malaria protection alternative to currently accepted notions. [unreadable] [unreadable]..
  10. Identifying Cytoprotectants for Photoreceptors and RPE Cells to Treat Dry AMD
    Susan Henry; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. Current Directions in Studying Mechanisms of Aging: 36th Annual AGE Meeting
    Holly Van Remmen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  12. Pd-Catalyzed Olefin Functionalization Reactions for Organic Synthesis
    MATTHEW SIGMAN; Fiscal Year: 2007
    ..The proposed research described herein will be approached using method discovery and development facilitated by elucidation of mechanistic details using physical organic chemistry techniques. ..
  13. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  14. GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND SEPSIS
    Zoltan Spolarics; Fiscal Year: 2004
    ..abstract_text> ..
  15. COPPER/ALBUMIN REDOX-CYCLING IN PREECLAMPSIA
    Valerian Kagan; Fiscal Year: 2003
    ....
  16. GENE MANIPULATION & H202 DEGRADATION IN THE OCULAR LENS
    Abraham Spector; Fiscal Year: 2001
    ..This is the first finding of tyrosine phosphorylation of the crystallins. We intend to further confirm this observation and attempt to determine the effect of such phosphorylation. ..
  17. INHIBITION OF ANGIOGENESIS BY TRUNCATED FGF RECEPTORS
    Anne Hanneken; Fiscal Year: 2001
    ..Specific Aim 5 is designed to determine how conditions which alter the levels of truncated FGFRs in the extracellular matrix modulate the biological activity of the extracellular matrix stores of FGF- 2. ..
  18. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  19. Irradiation Damage and Protection of Pulmonary Endothelium Oxidative Lipidomics
    Valerian E Kagan; Fiscal Year: 2010
    ....
  20. Ethanol Effects on Antigen Presentation in Liver Cells
    Natalia Osna; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  21. Antioxidant Defense System and Leydig Cell Aging
    Haolin Chen; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..