Genomes and Genes
Summary: A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).
Publications272 found, 100 shown here
- Artemisinin resistance in Plasmodium falciparum malariaArjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
N Engl J Med 361:455-67. 2009..There are recent concerns that the efficacy of such therapies has declined on the Thai-Cambodian border, historically a site of emerging antimalarial-drug resistance...
- Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal studyAung Pyae Phyo
Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 379:1960-6. 2012..We aimed to establish whether artemisinin resistance has spread or emerged on the Thailand-Myanmar (Burma) border...
- Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialArjen M Dondorp
Mahidol Oxford Tropical Medicine Research Unit MORU, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Lancet 376:1647-57. 2010..We compared parenteral treatment with either artesunate or quinine in African children with severe malaria...
- Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate studyChanaki Amaratunga
Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20852, USA
Lancet Infect Dis 12:851-8. 2012..We investigated contributions of both parasite genetics and host factors to the artemisinin-resistance phenotype in Pursat, western Cambodia...
- A major genome region underlying artemisinin resistance in malariaIan H Cheeseman
Texas Biomedical Research Institute, San Antonio, TX 78245, USA
Science 336:79-82. 2012....
- Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimatorJennifer A Flegg
WorldWide Anti malarial Resistance Network WWARN and Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Old Road, Oxford, OX3 7LJ, UK
Malar J 10:339. 2011..This lag complicates the clearance estimation, introduces observer subjectivity, and may influence the accuracy and consistency of reported results...
- Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trialArjen Dondorp
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Lancet 366:717-25. 2005..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
- Production of the antimalarial drug precursor artemisinic acid in engineered yeastDae Kyun Ro
California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Nature 440:940-3. 2006..annua, yield optimization and industrial scale-up will be required to raise artemisinic acid production to a level high enough to reduce artemisinin combination therapies to significantly below their current prices...
- Artemisinin resistance: current status and scenarios for containmentArjen M Dondorp
Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok10400, Thailand
Nat Rev Microbiol 8:272-80. 2010..to artemisinin monotherapies in subtherapeutic doses for over 30 years, and the availability of substandard artemisinins, have probably been the main driving force in the selection of the resistant phenotype in the region...
- Got ACTs? Availability, price, market share and provider knowledge of anti-malarial medicines in public and private sector outlets in six malaria-endemic countriesKathryn A O'Connell
Population Services International, Malaria and Child Survival Department, P O Box 43640, Nairobi, Kenya
Malar J 10:326. 2011..This paper presents supply side data from ACTwatch outlet surveys in Benin, the Democratic Republic of Congo (DRC), Madagascar, Nigeria, Uganda and Zambia...
- Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deploymentVerena Ilona Carrara
Shoklo Malaria Research Unit, Tak, Thailand
PLoS ONE 4:e4551. 2009....
- Monitoring fever treatment behaviour and equitable access to effective medicines in the context of initiatives to improve ACT access: baseline results and implications for programming in six African countriesMegan Littrell
Population Services International, Malaria and Child Survival Department, PO Box 43640, Nairobi, Kenya, Africa
Malar J 10:327. 2011..These data provide a baseline for monitoring interventions to increase ACT coverage, such as the Affordable Medicines Facility for malaria (AMFm)...
- Improved diagnostic testing and malaria treatment practices in ZambiaDavidson H Hamer
Center for International Health and Development, Boston University School of Public Health, Boston, Mass 02118, USA
JAMA 297:2227-31. 2007....
- Changes in health workers' malaria diagnosis and treatment practices in KenyaElizabeth Juma
Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi, Kenya
Malar J 10:1. 2011..Three years after the policy implementation, health workers' adherence to malaria diagnosis and treatment recommendations was evaluated...
- Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trialKojo Yeboah-Antwi
Center for Global Health and Development, Boston University School of Public Health, Boston, Massachusetts, United States of America
PLoS Med 7:e1000340. 2010..This study was designed to assess the effectiveness and feasibility of using CHWs to manage nonsevere pneumonia and uncomplicated malaria with the aid of rapid diagnostic tests (RDTs)...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparumM B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000..This has important implications for the development and efficacy of future antimalarial agents...
- Artemisinins target the SERCA of Plasmodium falciparumU Eckstein-Ludwig
Department of Cellular and Molecular Medicine, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
Nature 424:957-61. 2003b>Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing all asexual stages of Plasmodium falciparum...
- Artemisinin resistance in Cambodia: a clinical trial designed to address an emerging problem in Southeast AsiaHarald Noedl
Institute of Specific Prophylaxis and Tropical Medicine, Medical University of Vienna, Vienna, Austria
Clin Infect Dis 51:e82-9. 2010..This article provides additional data from a clinical trial that has been published in The New England Journal of Medicine...
- Piloting the global subsidy: the impact of subsidized artemisinin-based combination therapies distributed through private drug shops in rural TanzaniaOliver J Sabot
Malaria Control Team, Clinton Foundation HIV AIDS Initiative, Boston, Massachusetts, USA
PLoS ONE 4:e6857. 2009..To overcome this challenge, a global ACT subsidy has been proposed. We tested this proposal through a pilot program in rural Tanzania...
- Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trialAung Pyae Phyo
Shoklo Malaria Research Unit, Mae Sod
Clin Infect Dis 53:977-84. 2011..Chloroquine (CQ) remains the treatment of choice for Plasmodium vivax malaria. Initially confined to parts of Indonesia and Papua, resistance of P. vivax to CQ seems to be spreading, and alternative treatments are required...
- Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trialQuique Bassat
Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
PLoS ONE 4:e7871. 2009..Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in African children...
- The parasite clearance curveN J White
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Malar J 10:278. 2011..The factors affecting parasite clearance are reviewed. Methods of presentation and the approaches to analysis are discussed...
- Effectiveness of five artemisinin combination regimens with or without primaquine in uncomplicated falciparum malaria: an open-label randomised trialFrank Smithuis
Medecins Sans Frontieres Holland, Yangon, Myanmar
Lancet Infect Dis 10:673-81. 2010..We aimed to compare effectiveness of four fixed-dose ACTs and a loose tablet combination of artesunate and mefloquine, and assess the addition of a single gametocytocidal dose of primaquine...
- Adherence to a six-dose regimen of artemether-lumefantrine among uncomplicated Plasmodium falciparum patients in the Tigray Region, EthiopiaHailemariam Lemma
Tigray Health Bureau, Mekelle, Ethiopia
Malar J 10:349. 2011..The aim of this study was to measure patient adherence levels to the six-dose AL regimen for the treatment of uncomplicated P. falciparum malaria and to identify its determinant factors in rural areas of the Tigray region, Ethiopia..
- Pyronaridine-artesunate versus chloroquine in patients with acute Plasmodium vivax malaria: a randomized, double-blind, non-inferiority trialYi Poravuth
National Malaria Center, Phnom Penh, Cambodia
PLoS ONE 6:e14501. 2011..New antimalarials are needed for P. vivax and P. falciparum malaria. This study compared the efficacy and safety of pyronaridine-artesunate with that of chloroquine for the treatment of uncomplicated P. vivax malaria...
- Socially-marketed rapid diagnostic tests and ACT in the private sector: ten years of experience in CambodiaShunmay Yeung
Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, UK
Malar J 10:243. 2011..treatment with artemisinin combination therapy (ACT) and others are already facing parasites resistant to artemisinins.In this context, there is a crucial need to improve both access to and targeting of ACT through greater ..
- Artemisinin combination therapy for vivax malariaNicholas M Douglas
Menzies School of Health Research, Darwin, NT, Australia
Lancet Infect Dis 10:405-16. 2010..Analyses of the cost-effectiveness of ACTs for both Plasmodium species are needed to assess the role of these drugs in the control and elimination of vivax malaria...
- In vivo parasitological measures of artemisinin susceptibilityKasia Stepniewska
Mahidol Oxford Tropical Medicine Research Unit, Mahidol University, Bangkok, Thailand
J Infect Dis 201:570-9. 2010....
- Effect of malaria rapid diagnostic tests on the management of uncomplicated malaria with artemether-lumefantrine in Kenya: a cluster randomized trialJacek Skarbinski
Malaria Branch, US Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3724, USA
Am J Trop Med Hyg 80:919-26. 2009..30). RDTs could potentially improve malaria case management, but we urgently need to develop more effective strategies for implementing guidelines before large scale implementation...
- Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malariaJ Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Clin Pharmacol Ther 91:497-505. 2012..025) but had significantly lower day 7 piperaquine concentrations (P = 0.024) and total piperaquine exposures (P = 0.021), suggesting that an increased dose regimen for young children should be evaluated...
- Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugsTeun Bousema
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK
Malar J 9:136. 2010..Simple mathematical models were fitted to data from clinical trials in order to determine the mean gametocyte circulation time and duration of gametocyte carriage in treated malaria patients...
- Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan childrenEmmanuel Arinaitwe
Makerere University University of California San Francisco Research Collaboration, University of California, San Francisco 94143, USA
Clin Infect Dis 49:1629-37. 2009..However, which therapies are optimal is a matter of debate. We aimed to compare the short- and longer-term efficacy of 2 leading therapies in a cohort of young Ugandan children...
- In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in AfricaChristin Sisowath
Infectious Diseases Unit, Department of Medicine and Karolinska Institutet, Stockholm, Sweden
J Infect Dis 199:750-7. 2009..Identification of drug-specific parasite determinants that contribute to treatment failures will provide important tools for the detection and surveillance of AL resistance...
- Novel polymorphisms in Plasmodium falciparum ABC transporter genes are associated with major ACT antimalarial drug resistanceMaria Isabel Veiga
Malaria Research Lab, Department of Medicine, Karolinska Institutet, Stockholm, Sweden
PLoS ONE 6:e20212. 2011..Southeast Asia is an epicenter of emerging antimalarial drug resistance, including recent resistance to the artemisinins, the core component of all recommended antimalarial combination therapies...
- Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian childrenMichael Nambozi
Department of Clinical Sciences, Tropical Disease Research Center, P, O Box 71769, Ndola Zambia
Malar J 10:50. 2011..In 2002, the first-line treatment for uncomplicated malaria was changed to artemether-lumefantrine (AL) that has proved to be highly efficacious against multidrug resistant Plasmodium falciparum...
- In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem)Christin Sisowath
Malaria Research Laboratory, Unit of Infectious Diseases, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden
J Infect Dis 191:1014-7. 2005..This points to 86N as a potential marker of lumefantrine resistance in vivo, while suggesting that Coartem is not robust enough to avoid selection of resistance-associated mutations in some malarial settings...
- Poor quality vital anti-malarials in Africa - an urgent neglected public health priorityPaul N Newton
Wellcome Trust Mahosot Hospital Oxford University Tropical Medicine Research Collaboration, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR
Malar J 10:352. 2011..A vital component of malaria control rests on the availability of good quality artemisinin-derivative based combination therapy (ACT) at the correct dose. However, there are increasing reports of poor quality anti-malarials in Africa...
- Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisininAmar bir Singh Sidhu
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
J Infect Dis 194:528-35. 2006..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
- Malaria case-management following change of policy to universal parasitological diagnosis and targeted artemisinin-based combination therapy in KenyaAndrew Nyandigisi
Division of Malaria Control, Ministry of Public Health and Sanitation, Nairobi, Kenya
PLoS ONE 6:e24781. 2011..We evaluated changes in health systems and case-management indicators between the baseline survey undertaken before implementation of the policy and the follow-up survey following the first year of the implementation activities...
- In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1Leah Mwai
Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Program, Kilifi, Kenya
Antimicrob Agents Chemother 53:5069-73. 2009..Therefore, the use of LM-artemether is likely to lead to the selection of more CQ-susceptible parasites...
- Malaria drug shortages in Kenya: a major failure to provide access to effective treatmentBeth B Kangwana
Malaria Public Health and Epidemiology Group, Kenya Medical Research Institute Wellcome Trust Programme Nairobi, Kenya
Am J Trop Med Hyg 80:737-8. 2009..The shortage was in large part caused by a delayed procurement process. National ministries of health and the international community must address the current shortcomings facing antimalarial drug supply to the public sector...
- Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutationsAmar bir Singh Sidhu
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Science 298:210-3. 2002..pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria...
- Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in CambodiaPharath Lim
Institut Pasteur in Cambodia, Phnom Penh, Cambodia
Malar J 8:11. 2009....
- Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coastSteffen Borrmann
Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
PLoS ONE 6:e26005. 2011..The emergence of artemisinin-resistant P. falciparum malaria in South-East Asia highlights the need for continued global surveillance of the efficacy of artemisinin-based combination therapies...
- Adherence to artemether/lumefantrine treatment in children under real-life situations in rural TanzaniaDaudi O Simba
Department of Community Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
Trans R Soc Trop Med Hyg 106:3-9. 2012....
- No evidence of delayed parasite clearance after oral artesunate treatment of uncomplicated falciparum malaria in MaliAmelia W Maiga
Malaria Research and Training Center, Department of Epidemiology of Parasitic Diseases, Faculty of Medicine, Pharmacy, and Odonto Stomatology, University of Bamako, Mali
Am J Trop Med Hyg 87:23-8. 2012Plasmodium falciparum resistance to artemisinins by delayed parasite clearance is present in Southeast Asia...
- SMS for Life: a pilot project to improve anti-malarial drug supply management in rural Tanzania using standard technologyJim Barrington
SMS for Life Program Director, Forum 1 P 94, Novartis Campus, CH 4056 Basel, Switzerland
Malar J 9:298. 2010..Lack of visibility of anti-malarial stock levels at the health facility level is an important contributor to this problem...
- Adherence to treatment with artemether-lumefantrine for uncomplicated malaria in rural MalawiKimberly E Mace
Division of Parasitic Diseases and Malaria, Malaria Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Clin Infect Dis 53:772-9. 2011..Because of concerns about the complex dosing schedule, we assessed patient adherence to AL 2 years after routine implementation...
- Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studiesCho Naing
School of Postgraduate Studies and Research, International Medical University, Kuala Lumpur 57000, Malaysia
Trans R Soc Trop Med Hyg 107:65-73. 2013..The better safety profile of DP and once-daily dosage improves adherence and its fixed co-formulation ensures that both drugs are taken together. Our conclusion is that DP has the potential to become a first-line antimalarial drug...
- The ACTwatch project: methods to describe anti-malarial markets in seven countriesTanya Shewchuk
Malaria and Child Survival Department, Population Services International, P, O, Box 43640 00800, Nairobi, Kenya, Africa
Malar J 10:325. 2011..The project is designed to provide a comprehensive picture of the anti-malarial market to inform national and international anti-malarial drug policy decision-making...
- The magnitude and trend of artemether-lumefantrine stock-outs at public health facilities in KenyaRaymond K Sudoi
Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO Nairobi, Kenya
Malar J 11:37. 2012..Here, 2010-2011 data are reported from public facilities in Kenya where alarming stock-outs were revealed in 2008...
- Repeated treatment of recurrent uncomplicated Plasmodium falciparum malaria in Senegal with fixed-dose artesunate plus amodiaquine versus fixed-dose artemether plus lumefantrine: a randomized, open-label trialJean Louis A Ndiaye
Department of Medical Parasitology, Medical Faculty, Universite Cheikh Anta Diop, Dakar, Senegal
Malar J 10:237. 2011....
- Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestionNectarios Klonis
Department of Biochemistry and Australian Research Council Centre of Excellence for Coherent X ray Science, La Trobe University, 3086 Melbourne, Australia
Proc Natl Acad Sci U S A 108:11405-10. 2011..We treated Plasmodium falciparum for periods of a few hours to mimic clinical exposure to the short half-life artemisinins. We found that drug treatment retards parasite growth and inhibits uptake of hemoglobin, even at sublethal ..
- The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trialBeth P Kangwana
Malaria Public Health and Epidemiology Group, Kenya Medical Research Institute Wellcome Trust Research Programme, Kenya
PLoS Med 8:e1000437. 2011..This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months...
- The genetic map of Artemisia annua L. identifies loci affecting yield of the antimalarial drug artemisininIan A Graham
Centre for Novel Agricultural Products, Department of Biology, University of York, York YO10 5YW, UK
Science 327:328-31. 2010..Enrichment for positive QTLs in parents of new high-yielding hybrids confirms that the knowledge and tools to convert A. annua into a robust crop are now available...
- Artemisinin‐induced dormancy in plasmodium falciparum: duration, recovery rates, and implications in treatment failureFranka Teuscher
Malaria Drug Resistance and Chemotherapy Laboratory, Queensland Institute of Medical Research, Australian Army Malaria Institute, Brisbane, Australia
J Infect Dis 202:1362-8. 2010..The temporary arrest of the growth of ring-stage parasites (dormancy) after exposure to artemisinin drugs provides a plausible explanation for this phenomenon...
- The last man standing is the most resistant: eliminating artemisinin-resistant malaria in CambodiaRichard J Maude
Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
Malar J 8:31. 2009..The use of such an approach to investigate the likely effectiveness of different containment measures with the ultimate aim of eliminating artemisinin-resistant malaria is described...
- Moderate effect of artemisinin-based combination therapy on transmission of Plasmodium falciparumJ Teun Bousema
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
J Infect Dis 193:1151-9. 2006....
- Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007Pharath Lim
Institut Pasteur in Cambodia, Molecular Epidemiology Unit, Phnom Penh, Cambodia
Antimicrob Agents Chemother 54:2135-42. 2010..These results are worrisome, because they may signal deterioration of the efficacy of artesunate-mefloquine beyond the Cambodian-Thai border...
- Intrahost modeling of artemisinin resistance in Plasmodium falciparumSompob Saralamba
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Rajthevee, Bangkok 10400, Thailand
Proc Natl Acad Sci U S A 108:397-402. 2011..This result supports the hypothesis that artemisinin resistance mainly reflects reduced ring-stage susceptibility and predicts that doubling the frequency of dosing will accelerate clearance of artemisinin-resistant parasites...
- Population pharmacokinetics of lumefantrine in pregnant women treated with artemether-lumefantrine for uncomplicated Plasmodium falciparum malariaJoel Tarning
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
Antimicrob Agents Chemother 53:3837-46. 2009..In conclusion, altered pharmacokinetic properties of lumefantrine contribute to the high rates of failure of artemether-lumefantrine treatment in later pregnancy. Dose optimization is urgently needed...
- Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and EthiopiaKaren I Barnes
Division of Clinical Pharmacology, Department of Medicine, University of Cape Town Faculty of Health Sciences, Anzio Road, Observatory, 7925, South Africa
Malar J 8:S8. 2009..Artemisinin-based combination therapy has made a substantial contribution to reducing the burden of malaria in sub-Saharan Africa...
- Diversity of the sarco/endoplasmic reticulum Ca(2+)-ATPase orthologue of Plasmodium falciparum (PfATP6)Sabina Dahlström
Department of Medicine, Karolinska Institutet, Stockholm, Sweden
Infect Genet Evol 8:340-5. 2008..Plasmodium falciparum (PfATP6) has been suggested to be involved in the mechanism of action and resistance to artemisinins, the main constituent of artemisinin-based combination therapy (ACT)...
- High heritability of malaria parasite clearance rate indicates a genetic basis for artemisinin resistance in western CambodiaTim J C Anderson
Southwest Foundation for Biomedical Research, PO Box 760549, San Antonio, Texas 78245, USA
J Infect Dis 201:1326-30. 2010....
- Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistanceNicholas J White
Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, 420 6 Rajvithi Road, Bangkok 10400, Thailand
Malar J 8:253. 2009..The importance of anti-malarial treatment dosing has been underappreciated. Treatment recommendations are often for the lowest doses that produce "satisfactory" results...
- Initial evidence of reduction of malaria cases and deaths in Rwanda and Ethiopia due to rapid scale-up of malaria prevention and treatmentMac Otten
World Health Organization, Global Malaria Program, Geneva, Switzerland
Malar J 8:14. 2009....
- Predicting the clinical outcome of severe falciparum malaria in african children: findings from a large randomized trialLorenz von Seidlein
Department of Global Health, Menzies School of Health Research, Casuarina, Northern Territory, Australia
Clin Infect Dis 54:1080-90. 2012..Data from the largest randomized, controlled trial for the treatment of children hospitalized with severe malaria were used to identify such predictors of a poor outcome from severe malaria...
- The molecular mechanism of action of artemisinin--the debate continuesPaul M O'Neill
Department of Chemistry, University of Liverpool, Oxford Street, Liverpool L697ZD, UK
Molecules 15:1705-21. 2010..After a major change in treatment policies, artemisinins are now the frontline treatment to aid rapid clearance of parasitaemia and quick resolution of symptoms...
- Efficacy of artesunate-amodiaquine for treating uncomplicated falciparum malaria in sub-Saharan Africa: a multi-centre analysisJulien Zwang
Shoklo Malaria Research Unit, Mae Sot, Thailand
Malar J 8:203. 2009..It was necessary to evaluate the efficacy of ACT, recently adopted by the World Health Organization (WHO) and deployed over 80 countries, in order to make an evidence-based drug policy...
- Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with uncomplicated Plasmodium falciparum malaria: a randomised non-inferiority trialAntoinette K Tshefu
Ecole de Santé Publique, Faculte de Medecine, Universite de Kinshasa, Kinshasa, Democratic Republic of the Congo
Lancet 375:1457-67. 2010..We compared the efficacy and safety of pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria...
- Antimalarial drug resistance of Plasmodium falciparum in India: changes over time and spaceNaman K Shah
Department of Epidemiology, University of North Carolina, Chapel Hill, USA
Lancet Infect Dis 11:57-64. 2011..Strategies to reduce the emergence and spread of future drug resistance need to be proactive and supported by intensive monitoring...
- Declining in efficacy of a three-day combination regimen of mefloquine-artesunate in a multi-drug resistance area along the Thai-Myanmar borderKesara Na-Bangchang
Graduate Programme in Biomedical Sciences, Thammasat University, Thailand
Malar J 9:273. 2010....
- Feasibility and acceptability of home-based management of malaria strategy adapted to Sudan's conditions using artemisinin-based combination therapy and rapid diagnostic testKhalid A Elmardi
National Malaria Control Programme, Federal Ministry of Health, Khartoum, Sudan
Malar J 8:39. 2009..This research aimed to assess the feasibility and acceptability of home-based management of malaria (HMM) strategy using artemisinin-based combination therapy (ACT) for treatment and rapid diagnostic test (RDT) for diagnosis...
- Quality of malaria case management at outpatient health facilities in AngolaAlexander K Rowe
Centers for Disease Control and Prevention, Atlanta, USA
Malar J 8:275. 2009..Implementation was complicated by a policy that was sometimes ambiguous...
- Intravenous artesunate for severe malaria in travelers, EuropeThomas Zoller
Charite Universitatsmedizin, Berlin, Germany
Emerg Infect Dis 17:771-7. 2011..IV artesunate was an effective alternative to quinine for treatment of malaria patients in Europe. Patients should be monitored for signs of hemolysis, especially after parasitologic cure...
- Malaria case-management under artemether-lumefantrine treatment policy in UgandaDejan Zurovac
Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, Nairobi, Kenya
Malar J 7:181. 2008..Here the quality of AL case-management is reported from Uganda; approximately one year after AL replaced combination of chloroquine and sulphadoxine-pyrimethamine (CQ+SP) as recommended first line treatment for uncomplicated malaria...
- Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trialJane Achan
Makerere University School of Health Sciences, PO Box 7475, Kampala, Uganda
BMJ 339:b2763. 2009..To compare the effectiveness of oral quinine with that of artemether-lumefantrine in treating uncomplicated malaria in children...
- Artesunate dose escalation for the treatment of uncomplicated malaria in a region of reported artemisinin resistance: a randomized clinical trialDelia Bethell
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
PLoS ONE 6:e19283. 2011..This study investigated the impact of different AS doses on clinical and parasitological responses in malaria patients from an area of known artemisinin resistance in western Cambodia...
- Progress towards implementation of ACT malaria case-management in public health facilities in the Republic of Sudan: a cluster-sample surveyTarig M Abdelgader
Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Nairobi, Kenya
BMC Public Health 12:11. 2012..Three years after the launch of the strategy a health facility survey was undertaken to evaluate case-management practices and readiness of the health facilities and health workers to implement a new malaria case-management strategy...
- Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasiteA V Pandey
Malaria Research Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, P O Box 10504, New Delhi 110 067, India
J Biol Chem 274:19383-8. 1999....
- Early parasitological response following artemisinin-containing regimens: a critical review of the literatureDebashish Das
WorldWide Antimalarial Resistance Network, Oxford, UK
Malar J 12:125. 2013..Parasitaemia on Day 3 has been proposed as a useful alert of potential artemisinin resistance, however, the normal variation of parasite clearance observed in artemisinin-based combination therapy clinical trials is poorly documented...
- Artemisinins and the biological basis for the PfATP6/SERCA hypothesisSanjeev Krishna
Centre for Infection, Cellular and Molecular Medicine, St George s University of London, Cranmer Terrace, London, UK, SW17 0RE
Trends Parasitol 26:517-23. 2010..Herein, evidence is discussed that relates to this hypothesis as alternative suggestions for how artemisinins might act have been reviewed elsewhere.
- Pyronaridine-artesunate versus mefloquine plus artesunate for malariaRonnatrai Rueangweerayut
Department of Internal Medicine, Mae Sot General Hospital, Tak, Thailand
N Engl J Med 366:1298-309. 2012..Pyronaridine-artesunate is an artemisinin-based combination therapy under evaluation for the treatment of Plasmodium falciparum and P. vivax malaria...
- Plasmodium sensitivity to artemisinins: magic bullets hit elusive targetsXavier C Ding
Centre suisse de recherches scientifiques en Côte d Ivoire, 01 BP 1303, Abidjan 01, Cote d Ivoire
Trends Parasitol 27:73-81. 2011b>Artemisinins are efficacious antimalarial drugs widely employed as first-line treatment in endemic countries under the form of combined therapies...
- Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrineNahla B Gadalla
Department of Epidemiology, Tropical Medicine Research Institute, National Centre for Research, Khartoum, Sudan
Antimicrob Agents Chemother 55:5408-11. 2011..One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up...
- Treatment of imported severe malaria with artesunate instead of quinine--more evidence needed?Jakob P Cramer
Bernhard Nocht Clinic for Tropical Medicine, I, Department of Tropical Medicine, University Medical Center Hamburg Eppendorf, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany
Malar J 10:256. 2011..Here, the implications of existing evidence for the treatment of imported severe malaria are discussed...
- Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberRic N Price
Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
Lancet 364:438-47. 2004..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
- Improvements in access to malaria treatment in Tanzania after switch to artemisinin combination therapy and the introduction of accredited drug dispensing outlets - a provider perspectiveSandra Alba
Dept Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland
Malar J 9:164. 2010..Subsidized ALu was made available in both health facilities and ADDOs. The effect of these interventions on access to malaria treatment was studied in rural Tanzania...
- Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in UgandaCarole Fogg
Epicentre, Paris, France
Am J Trop Med Hyg 71:525-30. 2004..The high adherence to artemether-lumefantrine found in our study suggest that this drug is likely to be very effective in Mbarara provided that patients receive clear dosage explanations...
- Treatment outcome of intravenous artesunate in patients with severe malaria in the Netherlands and BelgiumAnnemarie R Kreeftmeijer-Vegter
Department of Internal Medicine, Division of Infectious Diseases, Academic Medical Center, Amsterdam, The Netherlands
Malar J 11:102. 2012..Fortunately, artesunate became available in the Netherlands and Belgium through a named patient programme. This is the largest case series of artesunate treated patients with severe malaria in Europe...
- Efficacy and safety of artemether-lumefantrine compared with quinine in pregnant women with uncomplicated Plasmodium falciparum malaria: an open-label, randomised, non-inferiority trialPatrice Piola
Epicentre, Paris, France
Lancet Infect Dis 10:762-9. 2010..We aimed to assess whether artemether-lumefantrine was at least as efficacious as oral quinine for the treatment of uncomplicated falciparum malaria during the second and third trimesters of pregnancy in Mbarara, Uganda...
- A trial of combination antimalarial therapies in children from Papua New GuineaHarin A Karunajeewa
School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia
N Engl J Med 359:2545-57. 2008..Malaria control is difficult where there is intense year-round transmission of multiple plasmodium species, such as in Papua New Guinea...
- Pharmacokinetics and pharmacodynamics of artesunate and dihydroartemisinin following oral treatment in pregnant women with asymptomatic Plasmodium falciparum infections in Kinshasa DRCMarie A Onyamboko
Kinshasa School of Public Health, Kinshasa, the Democratic Republic of Congo
Malar J 10:49. 2011..Artemisinin-based IPT regimens represent a promising potential alternative to SP. Pharmacokinetic and safety data supporting the use of artemisinin derivatives in pregnancy are urgently needed...
- A randomized trial of artesunate mefloquine versus artemether lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Senegalese childrenBabacar Faye
Department of Parasitology, Faculty of Medicine, University Cheikh Anta Diop, Dakar, Senegal
Am J Trop Med Hyg 82:140-4. 2010..No biological significant abnormal values related to the study drug have been reported. The new pediatric artesunate mefloquine formulated in granule fixed dose combination is well adapted to children in Africa...
- Health worker performance in the management of paediatric fevers following in-service training and exposure to job aids in KenyaBeatrice Wasunna
Malaria Public Health and Epidemiology Group, KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast CGMRC, Nairobi, Kenya Nairobi, Kenya
Malar J 9:261. 2010..In 2007, a new initiative was launched in one part of Kenya to improve malaria case-management through enhanced in-service training and provision of job aids...
- Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation studyMwinyi I Msellem
Malaria Control Programme, Ministry of Health and Social Welfare, Zanzibar, Tanzania
PLoS Med 6:e1000070. 2009..Our objective was to study the influence of RDT-aided malaria diagnosis on drug prescriptions, health outcomes, and costs in primary health care settings...
- Artesunate induces oncosis-like cell death in vitro and has antitumor activity against pancreatic cancer xenografts in vivoJi Hui Du
Central Laboratory, Nanshan Hospital, Guangdong Medical College, 518052 Shenzhen, Guangdong Province, People s Republic of China
Cancer Chemother Pharmacol 65:895-902. 2010....
- A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western KenyaPetra F Mens
Koninklijk Instituut voor de Tropen KIT Royal Tropical Institute, KIT Biomedical Research, Amsterdam, The Netherlands
Malar J 7:237. 2008....
- Failure of artesunate-mefloquine combination therapy for uncomplicated Plasmodium falciparum malaria in southern CambodiaWilliam O Rogers
Naval Medical Research Unit 2, Komp, P2P PLP LITBANGKES, Jl, Percetakan Negara No, 29, Jakarta 10560, Indonesia
Malar J 8:10. 2009..The efficacy of standard therapies for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria was assessed in Chumkiri, Kampot Province, Cambodia...
- Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in childrenBadara Cisse
Department of Parasitology and Mycology, Universite Cheikh Anta Diop, Dakar, Senegal
PLoS ONE 4:e7164. 2009....
- Seasonal intermittent preventive treatment for the prevention of anaemia and malaria in Ghanaian children: a randomized, placebo controlled trialMargaret Kweku
London School of Hygiene and Tropical Medicine, London, United Kingdom
PLoS ONE 3:e4000. 2008....
- FOSMIDOMYCIN RESISTANCE IN PLASMODIUM FALCIPARUMAUDREY RAGAN ODOM; Fiscal Year: 2013..are urgently needed to treat this disease, due to widespread chloroquine resistance and emerging resistance to artemisinins. P...
- Novel Artemisinin Derivatives for Cytomegalovirus TherapyRAVIT BOGER; Fiscal Year: 2013..The overall goal of this application is to investigate the anti-CMV activities of artemisinins. Several artemisinin derivatives are widely used in malaria therapy...
- Role of pfcrt in chloroquine resistance in P. falciparumDAVID ARMAND FIDOCK; Fiscal Year: 2013..of this former gold-standard antimalarial, and in SE Asia we are now witnessing the emergence of resistance to artemisinins, the fast-acting but very rapidly cleared core component of artemisinin-based combination therapies (ACTs)...
- Testing feasibility of artemisinin-based synthetic-lethal suppression of skin phoGeorg T Wondrak; Fiscal Year: 2013..Our recent research has identified artemisinins, an important class of redox-anti-malarials in clinical use worldwide, as synthetic- lethal anticancer agents ..
- Southeast Asia Malaria Research CenterLiwang Cui; Fiscal Year: 2013..Emerging resistance of parasites to artemisinins and circulation of counterfeit/substandard artemisinin drugs that threaten regional and global malaria control ..
- Within Host Selection of P. falciparum Variants by Artemisinin Combination TherapJONATHAN JAMES JULIANO; Fiscal Year: 2013..to define selection coefficients and better define the phenotype used to study drug resistance to artemisinins. This novel approach of quantitatively studying variant diversity within individuals will i) allow accurate ..
- Population biology of malaria drug resistance in YunnanZhaoqing Yang; Fiscal Year: 2010..To choose the best partner drug for artemisinins for a specific region, it is essential to have a comprehensive knowledge of drug resistance in the parasite ..
- Mechanisms of anti-schistosome artemisinin chemotherapyDavid Williams; Fiscal Year: 2006..b>Artemisinins are a new class of antimalarial and antischistosomal compounds that are thought to function via artemisinin ..
- Economical production of artemisinin precursorsJack Newman; Fiscal Year: 2004..b>Artemisinins, terpenoid compounds derived from traditional Chinese medicines used for centuries, have been acclaimed as the ..
- Economical production of artemisinin precursorsJack Newman; Fiscal Year: 2005..b>Artemisinins, terpenoid compounds derived from traditional Chinese medicines used for centuries, have been acclaimed as the ..
- TRIOXANES FOR CHEMOTHERAPY OF MALARIA AND CANCERGary Posner; Fiscal Year: 2005....
- Chemoprevention/Therapy Using Non-Calcemic Vitamin DGary Posner; Fiscal Year: 2006..Collectively, these studies will provide important structure- activity insights into the cancer chemoprotective and chemotherapeutic actions and molecular biology of vitamin D3 analogs. ..
- New Topical Therapies for PsoriasisMitchell Avery; Fiscal Year: 2007..The goal of this project is to develop a safe and effective new drug for topical treatment of psoriasis. [unreadable] [unreadable] [unreadable]..
- DEVELOPMENT OF NOVEL ANTIFUNGAL ANTIPC NATURAL PRODUCTSMitchell Avery; Fiscal Year: 2001....
- Dev & Testing of New Medications for Treatment of Emerging Infectious DiseasesMitchell Avery; Fiscal Year: 2006..This allows LADDS infrastructure to inch forward now to the last stages of drug development that are achievable with academic economics. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
- Burden of Malaria in Pregnancy in IndiaDavidson Hamer; Fiscal Year: 2007..The information generated by the study will also be instrumental in the development of new programs for preventing and mitigating the impact of MIP in India. [unreadable] [unreadable] [unreadable]..
- Congenital and neonatal malaria in MaliAbdoulaye Djimde; Fiscal Year: 2006..research grant ..
- Development of a cell-based method for high-throughput drug screening in malaria Liwang Cui; Fiscal Year: 2008..To facilitate antimalarial drug discovery, we propose to develop a highly sensitive, cell-based, one-step luminescent drug screen assay for high throughput screening of large chemical libraries. [unreadable] [unreadable] [unreadable]..
- Translational Control in Plasmodium Sexual DevelopmentLiwang Cui; Fiscal Year: 2005....
- Pathogenesis of falciparum malaria in infancyPatrick Duffy; Fiscal Year: 2004..Identifying new therapies for children is an urgent public health goal, but is not a funding priority for the United States Department of Defense. ..
- A randomized, controlled clinical trial of chloroquine as chemoprophylaxis versusMIRIAM LAUFER; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Molecular epidemiology of drug resistant malariaMIRIAM LAUFER; Fiscal Year: 2008..abstract_text> ..
- Biosensors for metabolic engineeringJay Keasling; Fiscal Year: 2006..abstract_text> ..
- Plasmodium vivax:Proteomic Analysis of Asexual and Sporozoite StagesLiwang Cui; Fiscal Year: 2007..Its recent resurgence in prevalence and emergence of drug- resistant parasite strains have raised a great concern for the future control of malaria. [unreadable] [unreadable] [unreadable]..
- MAPPING DRUG RESISTANCE GENES IN PLASMODIUM FALCIPARUMTim J Anderson; Fiscal Year: 2010..We aim to locate parasite genes underlying resistance. This will allow us to track the spread of resistance, to better understand how antimalarial drugs work, and to redesign drugs to restore their effectiveness. ..
- A Linkage Map for Schistosoma mansoniTim Anderson; Fiscal Year: 2008..Development of a linkage map will pave the way for finding these genes. [unreadable] [unreadable] [unreadable]..
- MATERNAL MALARIA--PARASITE ADHESION AND ANTIBODIESPatrick Duffy; Fiscal Year: 2001..Further, the delineation of binding domains and B cell epitopes will provide the basis to design an anti-adhesion vaccine to protect primigravid and other women susceptible to placental infection with the CSA-binding parasites. ..
- Pittsburgh Molecular Libraries Screening Center(RMI)JOHN LAZO; Fiscal Year: 2008..unreadable] [unreadable]..
- DRUGS AND DELIVERY SYSTEMS FOR OPPORTUNISTIC INFECTIONSMarvin Miller; Fiscal Year: 2002....
- Plasmodium Falciparum Metal MetabolismDavid Sullivan; Fiscal Year: 2009Interference with Plasmodium metal metabolism by the quinolines and artemisinins is a proven chemotherapeutic target...
- YEAST MODELS OF DRUG-RESISTANT PNEUMOCYSTIS CARINIISteven Meshnick; Fiscal Year: 2004..Ultimately, it is hoped that the results of this study will facilitate the rational use of antipneumocystis drugs. ..
- TOTAL SYNTHESIS OF SCABRONINE AGREGORY DUDLEY; Fiscal Year: 2002..The proposed strategy utilizes a novel coupling annulation to assemble the seven-membered ring. ..
- BIOCHEMICAL REGULATORS OF BLEOMYCIN INDUCED TUMORSJOHN LAZO; Fiscal Year: 2001..The Specific Aims are to: 1) develop cells and mice deficient in BH, 2) develop cells and mice that overexpress BH, 3) isolate and characterize potential proteins that interact with BH and, 4) analyze the regulation of BH expression. ..
- Plainning malaria training in Zambia Thomas Eisele; Fiscal Year: 2009..Tailoring a sustainable program using appropriate technology and a framework of collaboration in support of PMI activities will greatly increase the likelihood of controlling, and perhaps eventually eliminating, malaria in Zambia. ..
- Compositions for Prevention/Prophylactic Treatment of Poison Ivy DermatitisMahmoud Elsohly; Fiscal Year: 2006..This proposal addresses a major public health problem, namely contact allergic dermatitis and promises the development of an effective agent to address this problem. [unreadable] [unreadable]..
- MALARIA AND HIV IN PREGNANT WOMEN IN MALAWISteven Meshnick; Fiscal Year: 2005..The results of this study will have important implications for designing public health program s for antenatal care in African and should promote our understanding of the pathogenesis of MTCT. ..
- Bioactive Compounds from Acylnitroso CycloadductsMarvin Miller; Fiscal Year: 2006..abstract_text> ..
- In Vitro High Throughput Screening Assay for MKP-1(RMI)JOHN LAZO; Fiscal Year: 2005..No potent or selective small molecule inhibitors of this protein phosphatase are known. This proposal will provide sufficient reagents to permit a high throughput screening of 100,000 compounds. ..
- In Vitro High Throughput Screening Assay for MKP-3(RMI)JOHN LAZO; Fiscal Year: 2005..Nonetheless, no potent or selective small molecule inhibitors of this protein phosphatase have been identified. This proposal will provide sufficient reagents to permit a high throughput screening of 100,000 compounds ..
- Transmucosal Intra-Oral Drug Delivery System for THCMahmoud Elsohly; Fiscal Year: 2003..abstract_text> ..
- Derivatization/Functionalization of Natural Product(RMI)Marvin Miller; Fiscal Year: 2007..3. Broadly test the scaffold and derived libraries of novel compounds using the extensive set of assays in place at the Hans-Knoll Institute for Natural Products Research (HKI). ..
- Bleomycin Hydrolase and Alzheimer's DiseaseJOHN LAZO; Fiscal Year: 2004..These studies should provide new mechanistic information concerning the pathogenesis of AD as well as reagents for future therapeutic studies. ..
- Chemical Complementation Assay for MKP-3 (RMI)JOHN LAZO; Fiscal Year: 2005..This proposal will provide sufficient reagents, including cells and DMA transfection vectors, to permit the high throughput screening of 100,000 compounds. ..
- Molecular Epidemiology of Primary CMV InfectionRAVIT BOGER; Fiscal Year: 2008..This application will improve our understanding of acute CMV infection and will open new research directions in vaccine development. . [unreadable] [unreadable] [unreadable] [unreadable]..
- Routes of Transmission of HIV in Malawian MothersSteven Meshnick; Fiscal Year: 2006..Thus, the results of this project will suggest a comprehensive model of the vector, the route, and the maternal factors associated with HIV vertical transmission. ..
- Chemical Complementation Assay for MKP-1 (RMI)JOHN LAZO; Fiscal Year: 2005..This proposal will provide sufficient reagents, including cells and DMA transfection vectors, to permit the high throughput screening of 100,000 compounds. ..
- IMMUNE RESPONSES TO P FALCIPARUM IN HIGHLAND KENYAChandy John; Fiscal Year: 2002..falciparum antigens to susceptibility to infection and disease is important in the evaluation of these antigens as malaria vaccine candidates. ..
- Transcriptional & cell cycle control by dietary indolesGARY FIRESTONE; Fiscal Year: 2008..This information will be particularly valuable to develop new classes of I3C-based therapeutics for reproductive cancers. ..
- STEROID CONTROL OF EPITHELIAL CELL-CELL INTERACTIONSGARY FIRESTONE; Fiscal Year: 2007..abstract_text> ..
- Host Polymorphisms and Uncomplicated MalariaSunil Parikh; Fiscal Year: 2008..Parikh will be able to utilize modern molecular epidemiology techniques to investigate human genetic factors underlying susceptibility to malaria and he will be well equipped for a career in academic research. ..