tritolyl phosphates

Summary

Summary: A mixture of isomeric tritolyl phosphates. Used in the sterilization of certain surgical instruments and in many industrial processes.

Top Publications

  1. ncbi Neurologic and immunologic effects of exposure to corticosterone, chlorpyrifos, and multiple doses of tri-ortho-tolyl phosphate over a 28-day period in rats
    M Ehrich
    Laboratory of Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24016 0442, USA
    J Toxicol Environ Health A 67:431-57. 2004
  2. ncbi The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds
    Fengyuan Piao
    Department of Public Health, School of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie Pref 514 8507, Japan
    Toxicol Lett 143:65-71. 2003
  3. ncbi Triorthocresyl phosphate-induced neuronal losses in lumbar spinal cord of hens--an immunohistochemistry and ultrastructure study
    D L Mou
    Center of Infectious Disease, Tangdu Hospital Institute of Neuroscience, The Fourth Military Medical University, Xi an, Shaanxi, PR China
    Int J Neurosci 116:1303-16. 2006
  4. ncbi [Spinal cord neuronal apoptosis induced by triorthocresyl phosphate poisoning in hens]
    Ying Peng Wang
    Institute of Neurosciences of PLA, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 22:19-21. 2004
  5. ncbi Degradation of organophosphoric esters in leachate from a sea-based solid waste disposal site
    Yasunori Kawagoshi
    Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan
    Chemosphere 48:219-25. 2002
  6. ncbi Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG)
    Johannes Geier
    Information Network of Departments of Dermatology, University of Gottingen, Germany
    Contact Dermatitis 51:118-30. 2004
  7. pmc Identification and characterization of biomarkers of organophosphorus exposures in humans
    Jerry H Kim
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:61-71. 2010
  8. pmc Neuropathy target esterase
    P Glynn
    MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, U K
    Biochem J 344:625-31. 1999
  9. ncbi Glassy dynamics in nanoconfinement as revealed by (31)p NMR
    S Gradmann
    Experimentalphysik II, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Phys Chem B 113:8443-5. 2009
  10. ncbi [Tricresyl phosphate residue in garland chrysanthemum and its origin]
    Yasuo Tanaka
    Yokohama City Institute of Health 1 2 17 Takigashira, Isogo ku, Yokohama 235 0012, Japan
    Shokuhin Eiseigaku Zasshi 46:40-4. 2005

Research Grants

  1. Structure and Function of the Human PON1 Polymorphism
    Clement E Furlong; Fiscal Year: 2013

Scientific Experts

Detail Information

Publications118 found, 100 shown here

  1. ncbi Neurologic and immunologic effects of exposure to corticosterone, chlorpyrifos, and multiple doses of tri-ortho-tolyl phosphate over a 28-day period in rats
    M Ehrich
    Laboratory of Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24016 0442, USA
    J Toxicol Environ Health A 67:431-57. 2004
    ..Neuropathological examination revealed early stages of dose-related increased distal myelinated fiber axonal degeneration seen in the medullary fasciculus gracilis at only the highest dose of TOTP (300 mg/kg)...
  2. ncbi The effect of Calcicol as calcium tonic on delayed neurotoxicity induced by organophosphorus compounds
    Fengyuan Piao
    Department of Public Health, School of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie Pref 514 8507, Japan
    Toxicol Lett 143:65-71. 2003
    ..Meanwhile, our results indicate further that there is a relationship between a decrease in Ca(2+) concentration in tissues and induction of delayed neuropathy...
  3. ncbi Triorthocresyl phosphate-induced neuronal losses in lumbar spinal cord of hens--an immunohistochemistry and ultrastructure study
    D L Mou
    Center of Infectious Disease, Tangdu Hospital Institute of Neuroscience, The Fourth Military Medical University, Xi an, Shaanxi, PR China
    Int J Neurosci 116:1303-16. 2006
    ..Mitochondria morphologic changes appeared early (5 d) following exposure to TOCP, and developed in a time-dependent fashion. Apoptosis might be involved in the development of OPIDN, and play a role in the pathogenesis of OPIDN...
  4. ncbi [Spinal cord neuronal apoptosis induced by triorthocresyl phosphate poisoning in hens]
    Ying Peng Wang
    Institute of Neurosciences of PLA, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 22:19-21. 2004
    ..To investigate the role of neuronal apoptosis in organophosphorus poisoning-induced delayed neuropathy (OPIDN) and its dynamic pathological changes...
  5. ncbi Degradation of organophosphoric esters in leachate from a sea-based solid waste disposal site
    Yasunori Kawagoshi
    Osaka City Institute of Public Health and Environmental Sciences, Osaka, Japan
    Chemosphere 48:219-25. 2002
    ..It was considered that the composition ratio and the behavior of OPEs in leachate in the field reflects the biological and chemical degradation as well as the chemical properties of OPEs...
  6. ncbi Patch test results with the metalworking fluid series of the German Contact Dermatitis Research Group (DKG)
    Johannes Geier
    Information Network of Departments of Dermatology, University of Gottingen, Germany
    Contact Dermatitis 51:118-30. 2004
    ..The test series with current MWF allergens has to be kept up-to-date based on information from industry and to be kept concise by eliminating test substances which never cause positive reactions...
  7. pmc Identification and characterization of biomarkers of organophosphorus exposures in humans
    Jerry H Kim
    Department of Anesthesiology, University of Washington, Seattle, WA, USA
    Adv Exp Med Biol 660:61-71. 2010
    ..This research uses functional proteomics and enzyme activities to identify and characterize useful biomarkers of neurotoxic environmental and occupational OP exposures...
  8. pmc Neuropathy target esterase
    P Glynn
    MRC Toxicology Unit, University of Leicester, Leicester LE1 9HN, U K
    Biochem J 344:625-31. 1999
    ..These neuropathic organophosphates leave a negatively charged group covalently attached to the active-site serine residue, and it is suggested that this may cause a toxic gain of function in NTE...
  9. ncbi Glassy dynamics in nanoconfinement as revealed by (31)p NMR
    S Gradmann
    Experimentalphysik II, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Phys Chem B 113:8443-5. 2009
    ..As tau(r) changes with temperature, we were able to reintroduce the idea of a dynamic correlation length...
  10. ncbi [Tricresyl phosphate residue in garland chrysanthemum and its origin]
    Yasuo Tanaka
    Yokohama City Institute of Health 1 2 17 Takigashira, Isogo ku, Yokohama 235 0012, Japan
    Shokuhin Eiseigaku Zasshi 46:40-4. 2005
    ..These results indicate that TCP migrated to the garland chrysanthemum from the tubing used to keep greenhouses warm...
  11. ncbi [Tri-ortho-cresyl phosphate induced oligodendrocyte vacuolation and process degeneration in cultured hen oligodendrocytes]
    Shou zhi Wu
    The Center for Disease Control and Prevention of Xi an, Xi an 710054 China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 25:267-70. 2007
    ....
  12. pmc October 1942: a strange epidemic paralysis in Saval, Verona, Italy. Revision and diagnosis 50 years later of tri-ortho-cresyl phosphate poisoning
    L Tosi
    Ospedale Sacro Cuore, Negrar, Verona, Italy
    J Neurol Neurosurg Psychiatry 57:810-3. 1994
    ..Contamination of the ground from a rubbish dump near the farmyard would explain the epidemiology of the Saval outbreak...
  13. ncbi Organophosphate flame retardants and plasticizers in indoor air
    Paul C Hartmann
    EAWAG Swiss Federal Institute for Environmental Science and Technology, Ueberlandstr 133, CH 8600 Dubendorf, Switzerland
    Chemosphere 57:781-7. 2004
    ..The results of the risk assessment indicate that the observed concentrations are below the predicted threshold for human health effects...
  14. ncbi Characterization of high-affinity binding sites for diisopropylfluorophosphate (DFP) from chicken spinal cord membranes
    N Konno
    Department of Public Health, Fukushima Medical College, Japan
    Biochem Pharmacol 48:2073-9. 1994
    ..The DFP binding sites corresponding to the 110 kDa protein were insensitive to eserine, a potent anti-cholinesterase agent...
  15. ncbi Clinical manifestations and leukocyte neurotoxic esterase and red blood cell and plasma acetylcholinesterase activities in swine following a single oral dose of tri-o-cresyl phosphate
    D S Barrett
    College of Veterinary Medicine, Kansas State University, Manhattan 66506
    Vet Hum Toxicol 36:103-9. 1994
    ..All survivors developed signs of delayed neurotoxicity 10-12 d after TOCP administration, and 70% or greater inhibition of neurotoxic esterase activity in leukocytes was apparent during the first 48 h postdosing...
  16. ncbi Neuropathological studies of rats following multiple exposure to tri-ortho-tolyl phosphate, chlorpyrifos and stress
    Bernard S Jortner
    Laboratory for Neurotoxicity Studies, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech Blacksburg Virginia 24061 0442 USA
    Toxicol Pathol 33:378-85. 2005
    ....
  17. ncbi Pathogenesis of cholesteryl lipidosis of adrenocortical and ovarian interstitial cells in F344 rats caused by tricresyl phosphate and butylated triphenyl phosphate
    J R Latendresse
    Naval Medical Research Institute Toxicology Detachment, Wright Patterson Air Force Base, Ohio 45433
    Toxicol Appl Pharmacol 122:281-9. 1993
    ..An inhibition of nCEH in the storage and uptake pathways by triaryl phosphates most likely resulted in the striking accumulation of CE in cytoplasmic lipid droplets of AC and OI cells in F344 rats...
  18. ncbi Evaluation of the hazards of industrial exposure to tricresyl phosphate: a review and interpretation of the literature
    P H Craig
    Mobil Business Resources Corporation, Paulsboro, New Jersey, USA
    J Toxicol Environ Health B Crit Rev 2:281-300. 1999
    ..Because individual TCP brands and synthesis methods vary, manufacturers should be consulted concerning the properties of their individual products...
  19. ncbi Effects of tri-o-cresyl phosphate on serum estrogen and progesterone concentration and ATPase activity in the shell gland of adult hens
    Y J Wu
    Department of Toxicology, Institute of Zoology, Academia Sinica, Beijing, People s Republic of China
    Chemosphere 41:183-6. 2000
    ..05). The serum E2 concentration was significantly reduced in TOCP-treated hens (P < 0.01); however, progesterone levels were unaffected...
  20. ncbi Prioritization of NTP reproductive toxicants for field studies
    W J Moorman
    National Institute for Occupational Safety and Health NIOSH, 4676 Columbia Pkwy, Cincinnati OH 45226, USA
    Reprod Toxicol 14:293-301. 2000
    ..The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N, N-dimethylformamide...
  21. ncbi Preparation of refractive index matching polymer film alternative to oil for use in a portable surface-plasmon resonance phenomenon-based chemical sensor method
    Takashi Masadome
    Department of Chemical Science and Engineering, Ariake National College of Technology, Omuta, Fukuoka 836 8585, Japan
    Anal Bioanal Chem 373:222-6. 2002
    ..The utility of the matching polymer film for the SPR sensor was confirmed by the detection of anti-human albumin, based on an antigen-antibody reaction...
  22. ncbi Toxicokinetics of [14C]-saligenin cyclic-o-tolyl phosphate in anesthetized male F-344 rats
    L T Burka
    National Toxicology Program, National Institute of Environmental Health Sciences Research, Triangle Park, North Carolina 27709
    Reprod Toxicol 7:81-6. 1993
    ..There is no evidence, however, of active uptake of SCOTP from blood by the testes. Evidence was obtained that SCOTP may act as an alkylating agent...
  23. ncbi Quantitative analysis of neuronal damage induced by tri-ortho-cresyl phosphate in Wistar rats
    K Inui
    Toxicology Division, Institute of Environmental Toxicology, Tokyo, Japan
    Fundam Appl Toxicol 20:111-9. 1993
    ..Morphometric examinations on semi-thin sections and frozen sections stained with Nauta's method were demonstrated to be useful for objective evaluation of OPIDN in the rat...
  24. ncbi A widely applicable electrode sensitive to basic drugs based on poly(vinyl chloride) membrane plasticized with tricresyl phosphate
    H Suzuki
    Pharmaceutical Research Center, Kanebo, Ltd, Osaka, Japan
    Chem Pharm Bull (Tokyo) 41:1123-6. 1993
    ..Trazodone hydrochloride and trihexyphenidyl hydrochloride in tablets were determined, and the results compared favorably with those obtained by conventional methods...
  25. ncbi Organophosphate induced delayed neuropathy in genetically dissimilar chickens: studies with tri-ortho-cresyl phosphate (TOCP) and trichlorfon
    Georgino Honorato de Oliveira
    Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences UNESP, Araraquara, SP, Brazil
    Toxicol Lett 136:143-50. 2002
    ..In addition, 70-80% of NTE inhibition was necessary but was not sufficient to produce OPIDN in chickens, since babcock and hy-line w36 chickens exhibited NTE inhibition in the range of 70-80% without clinical signs of OPIDN...
  26. ncbi DNA adduct formation in Salmonella typhimurium, cultured liver cells and in Fischer 344 rats treated with o-tolyl phosphates and their metabolites
    A Mentzschel
    Institut fur Toxikologie, Universitat Wurzburg, Germany
    Carcinogenesis 14:2039-43. 1993
    ..The results indicate that in addition to the well established neurotoxicity, some o-tolyl phosphates may have a carcinogenic potential...
  27. ncbi Expression changes of neurofilament subunits in the central nervous system of hens treated with tri-ortho-cresyl phosphate (TOCP)
    Xiu Lan Zhao
    Institute of Toxicology, Shandong University, 44 Wenhua West Road, Jinan 250012, China
    Toxicology 223:127-35. 2006
    ....
  28. ncbi Aberrant activation of CDK5 is involved in the pathogenesis of OPIDN
    Ying Peng Wang
    Institute of Neurosciences, The Fourth Military Medical University, Xi an, China
    J Neurochem 99:186-97. 2006
    ..Axonal transport of these nerves was faster than of their opposite side and of those simply treated by TOCP. These findings indicate aberrant activation of CDK5 may be involved in the pathogenesis of OPIDN...
  29. ncbi Reduction of retrograde axonal transport associated-proteins motor proteins, dynein and dynactin in the spinal cord and cerebral cortex of hens by tri-ortho-cresyl phosphate (TOCP)
    Fuyong Song
    Institute of Toxicology, Shandong University, Jinan, Shandong, PR China
    Neurochem Int 60:99-104. 2012
    ..In conclusion, the reduction of the motor proteins, dynein and dynactin, might be associated with the disruption of retrograde neuronal axonal transport in OPIDN...
  30. ncbi The effect of testosterone or estradiol on the development of TOCP-induced delayed neurotoxicity in immature broiler-breed cockerels
    F A Fathy
    Department of Animal Science, Michigan State University, East Lansing 48824
    Vet Hum Toxicol 32:416-8. 1990
    ..This study demonstrated that sex hormones can modulate the clinical effects of TOCP in immature cockerels through unknown mechanisms that are similar to those reported for corticosterone in adult chickens...
  31. ncbi Assessment of the delayed neurotoxicity of tributyl phosphate, tributoxyethyl phosphate, and dibutylphenyl phosphate
    C D Carrington
    Department of Pharmacology, Duke University Medical Center, Durham, North Carolina
    Toxicol Ind Health 6:415-23. 1990
    ..TBEP administration resulted in about 45% inhibition of acetycholinesterase (AChE) in brain. These results indicate that TBP, TBEP, and DBPP are all unlikely to cause OPIDN with any single sublethal dose...
  32. ncbi Involvement of neuropathy target esterase in tri-ortho-cresyl phosphate-induced testicular spermatogenesis failure and growth inhibition of spermatogonial stem cells in mice
    Jia Xiang Chen
    Department of Physiology, Medical College of Nanchang University, Nanchang 330006, PR China
    Toxicol Lett 211:54-61. 2012
    ..These results point to a role of NTE in regulating proliferation of mouse spermatogonial stem cells and provide a novel insight into the mechanism by which TOCP diminishes on the sperm number in the mouse testis...
  33. ncbi Disposition, elimination, and metabolism of tri-o-cresyl phosphate following daily oral administration in Fischer 344 male rats
    S G Somkuti
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
    Arch Toxicol 64:572-9. 1990
    ..These results may account for testicular toxicity in rats given daily oral administrations of TOCP but not following a single oral dose...
  34. ncbi Occupational exposure of air crews to tricresyl phosphate isomers and organophosphate flame retardants after fume events
    Birgit Karin Schindler
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr Universität Bochum, Germany
    Arch Toxicol 87:645-8. 2013
    ..A slight occupational exposure of air crews to organophosphates was shown...
  35. ncbi Protective effect of taurine on triorthocresyl phosphate (TOCP)-induced cytotoxicity in C6 glioma cells
    Yachen Li
    Department of Occupational and Environmental Health, Dalian Medical University, Dalian, China
    Adv Exp Med Biol 776:231-40. 2013
    ..However, taurine prevented these decreases. Our results suggested that taurine has protective effect on TOCP-induced toxicity to glioma cells via elevating antioxidant capacity...
  36. ncbi Use of an avian hepatocyte assay and the avian Toxchip Polymerse chain reaction array for testing prioritization of 16 organic flame retardants
    Emily Porter
    National Wildlife Research Centre, Environment Canada, Ottawa, Ontario, Canada
    Environ Toxicol Chem 33:573-82. 2014
    ....
  37. ncbi Vacuolation of sensory ganglion neuron cytoplasm in rats with long-term exposure to organophosphates
    T Rogers-Cotrone
    Laboratory for Neurotoxicity Studies, VA MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia 24061, USA
    Toxicol Pathol 38:554-9. 2010
    ..There was no associated cell death, even when vacuoles were large. This is the initial report of an association of this change following exposure to neurotoxic organophosphates...
  38. ncbi Simple and rapid determination of iodide in table salt by stripping potentiometry at a carbon-paste electrode
    Ivan Svancara
    Department of Analytical Chemistry, Faculty of Chemical Technology, University of Pardubice, nam Cs Legii 565, 532 10 Pardubice, Czech Republic
    Anal Bioanal Chem 372:795-800. 2002
    ....
  39. ncbi Effect of route of administration on the development of organophosphate-induced delayed neurotoxicity in 4-week-old chicks
    B A Olson
    Department of Animal Science, Michigan State University, East Lansing 48824
    J Toxicol Environ Health 23:499-505. 1988
    ....
  40. ncbi Toxicity of an acute dose of agent VX and other organophosphorus esters in the chicken
    B W Wilson
    Department of Avian Sciences, University of California, Davis 95616
    J Toxicol Environ Health 23:103-13. 1988
    ..Injections of up to 150 micrograms/kg of VX with antidotes did not cause locomotor or histological signs of organophosphorus-induced delayed neuropathy, but single injections of 400 mg TOCP/kg did...
  41. ncbi Determination of airborne trialkyl and triaryl organophosphates originating from hydraulic fluids by gas chromatography-mass spectrometry. Development of methodology for combined aerosol and vapor sampling
    K Solbu
    National Institute of Occupational Health, P O Box 8149 Dep, N 0033 Oslo, Norway
    J Chromatogr A 1161:275-83. 2007
    ..024 and 0.28 mg/m(3), as well as during aircraft maintenance displaying tri-n-butyl phosphate air concentrations of 0.061 and 0.072 mg/m(3)...
  42. ncbi Tricresyl phosphate and triphenyl phosphate are toxic to cultured human, monkey and dog cells
    K Mochida
    Department of Microbiology, Shimane Prefectural Institute of Public Health and Environmental Science, Matsue, Japan
    Zentralbl Bakteriol Mikrobiol Hyg B 185:427-9. 1988
    ..We report herein evidence that the flame retardants tricresyl phosphate and triphenyl phosphate are toxic to KB, HEL-R66, Vero and MDCK cells grown in culture. The former is more toxic than the latter...
  43. ncbi Occurrence and distribution of organophosphate flame retardants/plasticizers in wastewater treatment plant sludges from the Pearl River Delta, China
    Xiangying Zeng
    State Key Laboratory of Organic Geochemistry, Guangdong Key Laboratory of Environment and Resources, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou, China
    Environ Toxicol Chem 33:1720-5. 2014
    ..9 µg/kg), TBEP (783.7 µg/kg), TPhP (656.7 µg/kg), and tritolyl phosphate (265.0 µg/kg), which implied different discharge sources in the studied areas...
  44. ncbi Respiratory and dermal exposure to organophosphorus flame retardants and tetrabromobisphenol A at five work environments
    Maija S E Mäkinen
    Department of Environmental Science, University of Kuopio, P O Box 1627, 70211 Kuopio, Finland
    Environ Sci Technol 43:941-7. 2009
    ..The geometric mean of totalFR levels in patch samples ranged between 1.5 and 24 ng/cm2 and in hand wash samples between 3.5 and 34 microg/ two hands. The health effects of the measured FR levels remain unknown...
  45. ncbi Thirteen-year follow-up of patients with tri-ortho-cresyl phosphate poisoning in northern suburbs of Xi'an in China
    Lian Wang
    Department of Neurology, Kunming General Hospital of Chengdu Military Region, Kunming 650032, PR China
    Neurotoxicology 30:1084-7. 2009
    ..TOCP showed long-term effects on the nervous system and influenced the quality of life. OP compounds should be strictly regulated to prevent similar occurrences...
  46. ncbi [Aerotoxic syndrome: fact or fiction?]
    Leroy J de Graaf
    Medisch Spectrum Twente, Enschede
    Ned Tijdschr Geneeskd 158:A6912. 2014
    ..Possible adverse health effects are attributed factors including organophosphate tricresyl phosphate, a component of aircraft engine oil that is potently neurotoxic...
  47. ncbi [The differential expression of Stathmin in the spinal cord tissue of hens exposed to tri-o-cresyl phosphate]
    Xue Rong Han
    Department of Occupational and Enviromental Health, Dalian Medical University, Dalian, Liaoning Province 116044, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 29:917-20. 2011
    ....
  48. ncbi Sensitivity of 2H NMR spectroscopy to motional models: proteins and highly viscous liquids as examples
    D Kruk
    University of Warmia and Mazury Olsztyn, Faculty of Mathematics and Computer Science, Sloneczna 54, PL 10710 Olsztyn, Poland
    J Chem Phys 136:244509. 2012
    ..J. Chem. Phys. 135, 224511 (2011)] has been used as it allows simulating quadrupolar spectra for arbitrary motional conditions by employing the stochastic Liouville equation...
  49. ncbi Inhibition pathways of the potent organophosphate CBDP with cholinesterases revealed by X-ray crystallographic snapshots and mass spectrometry
    Eugenie Carletti
    Institut de Biologie Structurale J P Ebel, Commissariat a l Energie Atomique, 41, rue Jules Horowitz, F 38027 Grenoble, France
    Chem Res Toxicol 26:280-9. 2013
    ..Our study thus shows that only prophylactic and symptomatic treatments are viable to counter the inhibition of AChE and BChE by CBDP...
  50. ncbi Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine
    Hosny Ibrahim
    Chemistry Department, Faculty of Science, Cairo University, Cairo, Egypt
    J Pharm Biomed Anal 38:624-32. 2005
    ..The developed electrode was successfully used for the potentiometric determination of PD in its aqueous solutions, pharmaceutical preparation, and urine in batch and flow injection analysis (FIA)...
  51. ncbi [Effect of phenylmethylsulfonyl fluoride pretreated on neurofilament subunits in spinal cords of hens administrated with tri-o-cresyl phosphate]
    Dan Dan Dou
    Institute of Toxicology, School of Public Health, Shandong University, Jinan 250012, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 28:250-4. 2010
    ....
  52. pmc Acute airway irritation of methyl formate in mice
    Søren T Larsen
    National Research Centre for the Working Environment, Lersø Parkallé 105, 2100, Copenhagen, Denmark
    Arch Toxicol 86:285-92. 2012
    ....
  53. ncbi Exposure of aircraft maintenance technicians to organophosphates from hydraulic fluids and turbine oils: a pilot study
    Birgit Karin Schindler
    Institute for Prevention and Occupational Medicine of the German Social Accident Insurance, Institute of the Ruhr University Bochum IPA, Bochum, Germany Electronic address
    Int J Hyg Environ Health 217:34-7. 2014
    ..Further studies are necessary to collect information on sources, routes of uptake and varying exposures during different work tasks, evaluate possible health effects and to set up appropriate protective measures...
  54. doi Cathodic electrochemiluminescence and reversible electrochemistry of [Ru(bpy)3](2+/1+) in aqueous solutions on tricresyl phosphate-based carbon paste electrode with extremely high hydrogen evolution potential
    Ye Tian
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
    Anal Bioanal Chem 405:3427-30. 2013
    ..Since CPEs have been widely used, CPEs with high hydrogen evolution potential are versatile platforms for electrochemical study and cathodic ECL study...
  55. ncbi Activation of mitochondria-mediated apoptotic pathway in tri-ortho-cresyl phosphate-induced delayed neuropathy
    Chaoshuang Zou
    Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, PR China
    Neurochem Int 62:965-72. 2013
    ..Taken together, these findings indicate that the administration of TOCP can induce neuron apoptosis in hen spinal cords, which might be mediated by the activation of mitochondrial apoptotic pathway...
  56. ncbi Induction of autophagy by TOCP in differentiated human neuroblastoma cells lead to degradation of cytoskeletal components and inhibition of neurite outgrowth
    Jia Xiang Chen
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, 1 5 Beichenxi Road, Beijing 100101, PR China
    Toxicology 310:92-7. 2013
    ..Taken together, these results indicated that TOCP treatment induced autophagy in differentiated SH-SY5Y cells, which lead to degradation of cytoskeletal components and inhibition of neurite outgrowth. ..
  57. pmc Development of diagnostics in the search for an explanation of aerotoxic syndrome
    Lawrence M Schopfer
    Eppley Institute, University of Nebraska Medical Center, Omaha, 68198, USA
    Anal Biochem 404:64-74. 2010
    ..It is concluded that toxic gases or oil mists in cabin air may form adducts on plasma butyrylcholinesterase and albumin, detectable by mass spectrometry...
  58. ncbi Serum carboxylesterase activity in various strains of rats: sensitivity to inhibition by CBDP (2-/o-cresyl/4H:1:3:2-benzodioxaphosphorin-2-oxide)
    J G Clement
    Biomedical Defence Section, Defence Research Establishment Suffield, Ralston, Alta, Canada
    Arch Toxicol 64:414-6. 1990
    ....
  59. ncbi Myelinated nerve fiber regeneration following organophosphorus ester-induced delayed neuropathy
    B S Jortner
    Virginia Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061
    Neurotoxicology 10:717-26. 1989
    ..These studies indicate that in OPIDN there is a transient period of neuronal injury, and that damaged cells having peripherally directed neurites are likely able to undertake axonal regeneration...
  60. ncbi Phencyclidine (PCP)-like inhibition of N-methyl-D-aspartate-evoked striatal acetylcholine release, H-TCP binding and synaptosomal dopamine uptake by metaphit, a proposed PCP receptor acylator
    L D Snell
    Department of Pharmacology and Toxicology University of Texas Medical Branch, Galveston 77550
    Life Sci 41:2645-54. 1987
    ..These data are discussed in relation to the interaction of metaphit with PCP receptors in various systems...
  61. ncbi Phenylmethylsulfonyl fluoride protects against the degradation of neurofilaments in tri-ortho-cresyl phosphate (TOCP) induced delayed neuropathy
    Fuyong Song
    Institute of Toxicology, Shandong University, Jinan, Shandong 250012, PR China
    Toxicology 262:258-64. 2009
    ....
  62. ncbi Phrenic nerve-diaphragm preparation in situ for studying the detoxification of soman in the rat liver
    S Cetkovic
    Medical Department, Military Technical Institute, Belgrade, Yugoslavia
    J Pharmacol Methods 19:31-7. 1988
    ..Pretreatment with phenobarbital reduced, whereas previous application of tri-O-cresyl phosphate (TOCP) enhanced, effectiveness of soman administered i.p. Possible mechanisms of detoxification and the features of the method are discussed...
  63. ncbi Design of a small personal air monitor and its application in aircraft
    Chris van Netten
    School of Population and Public Health, University of British Columbia, James Mather Building, 5804 Fairview Avenue, Vancouver BC, Canada V6T 1Z3
    Sci Total Environ 407:1206-10. 2009
    ..It was concluded that the air sampler was capable of monitoring air concentrations of TCP isomers in aircraft above 4.5 nanogram/m(3)...
  64. ncbi The homeostasis of phosphatidylcholine and lysophosphatidylcholine in nervous tissues of mice was not disrupted after administration of tri-o-cresyl phosphate
    Wei Yuan Hou
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China
    Toxicol Sci 109:276-85. 2009
    ..Differences in inhibition of NTE, LysoPLA, and PLB activities by TOCP between mice and hens may elucidate why these two species display different signs after exposure to the same neuropathic OPs...
  65. ncbi Cytoskeletal proteins as targets for organophosphorus compound and aliphatic hexacarbon-induced neurotoxicity
    M B Abou-Donia
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
    Toxicology 49:469-77. 1988
    ..This treatment also decreased protein phosphorylation of neurofilament proteins as well as MAP-2. These studies demonstrate the involvement of cytoskeletal proteins in the molecular pathogenesis of chemical-induced neurotoxicity...
  66. ncbi Chronic treatment with cholinesterase inhibitors increases alpha 2-adrenoceptors in rat brain
    P J Hollingsworth
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor 48109
    Eur J Pharmacol 153:167-73. 1988
    ..The possibility is discussed that increases in brain alpha 2-adrenoceptors are related to the alterations in mood seen in individuals chronically exposed to organophosphorus cholinesterase inhibitors...
  67. ncbi Growth inhibition and induction of G(1) phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate
    Ding Xin Long
    Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Datunlu Road, Beijing 100101, PR China
    Toxicol Lett 181:47-52. 2008
    ....
  68. ncbi Effects of calcium gluconate and PMSF in the treatment of acute intoxication of chicken by TOCP
    G A Muzardo
    School of Pharmaceutical Sciences UNESP São Paulo State University, Sao Paulo, Brazil
    Hum Exp Toxicol 27:247-52. 2008
    ..In summary, the sooner the Ca-Glu is started, the less severe the neuropathy effects...
  69. ncbi Determination of ortho-cresyl phosphate isomers of tricresyl phosphate used in aircraft turbine engine oils by gas chromatography and mass spectrometry
    G De Nola
    Defence Science and Technology Organisation, Department of Defence, 506 Lorimer Street, Fishermans Bend, Melbourne, Victoria 3207, Australia
    J Chromatogr A 1200:211-6. 2008
    ..The ability to analyse for the mono-o-cresyl isomers allows the toxicity of TCP to be based on the latter isomers rather than on the less toxic tri-o-cresyl phosphate isomer...
  70. ncbi Use of the biventer cervicis nerve-muscle preparation to detect early changes following exposure to organophosphates inducing delayed neuropathy
    H A El-Fawal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061 0042
    Fundam Appl Toxicol 15:108-20. 1990
    ..This study suggests that the biventer cervicis nerve-muscle preparation may prove useful for detection of functional and morphological changes that occur during the interval between NTE inhibition and appearance of clinical deficits...
  71. ncbi Exposure to airborne organophosphates originating from hydraulic and turbine oils among aviation technicians and loaders
    Kasper Solbu
    National Institute of Occupational Health, PO Box 8149 Dep, N 0033, Oslo, Norway
    J Environ Monit 12:2259-68. 2010
    ..The tailored OP and the general oil aerosol sampling methods were compared, displaying the advantages of tailored OP sampling for such exposure assessments...
  72. ncbi Organophosphates in aircraft cabin and cockpit air--method development and measurements of contaminants
    Kasper Solbu
    National Institute of Occupational Health, PO Box 8149 Dep, N 0033 Oslo, Norway
    J Environ Monit 13:1393-403. 2011
    ..02)...
  73. ncbi Biochemical changes in sciatic nerve of hens treated with tri-o-cresyl phosphate: increased phosphorylation of cytoskeletal proteins
    E S Lapadula
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
    Neurochem Int 20:247-55. 1992
    ..These results confirm earlier observation of the close temporal relationship between increased cytoskeletal protein phosphorylation and the development and OPIDN...
  74. ncbi Guinea pig and rat hepatic microsomal metabolism of monocrotaline
    S R Dueker
    Department of Veterinary Pharmacology and Toxicology, University of California, Davis 95616
    Drug Metab Dispos 20:275-80. 1992
    ..Dehydropyrrole was found to be the major pyrrolic metabolite in the guinea pig, although colorimetric analysis indicated multiple pyrrolic moieties in the rat microsomal incubations...
  75. ncbi Delayed neurotoxicity of trixylenyl phosphate and a trialkyl/aryl phosphate mixture, and the modulating effect of atropine on tri-o-tolyl phosphate-induced neurotoxicity
    A Mortensen
    Institute of Toxicology, National Food Agency, Søborg, Denmark
    Neurotoxicology 13:347-54. 1992
    ..In conclusion, the neurotoxic potential of the hydraulic fluids was very low. The effect of atropine and the concentration of the test compound in oil vehicle should be taken into consideration when designing experiments on OPIDN...
  76. ncbi Role of socialization, stress and sex of chickens on response to anesthesia and on response to an organophosphate neurotoxicant
    A Odom
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061
    Vet Hum Toxicol 34:134-7. 1992
    ..Response to endogenous substances in chickens depends both on sex and on familiarity to humans...
  77. ncbi Persistent alterations of calmodulin kinase II activity in chickens after an oral dose of tri-o-cresyl phosphate
    E S Lapadula
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
    Biochem Pharmacol 42:171-80. 1991
    ..This finding supports the significance of altered calmodulin kinase II in the pathogenesis of OPIDN...
  78. ncbi Absence of delayed neurotoxicity and increased plasma butyrylcholinesterase activity in triallate-treated hens
    D M Lapadula
    Duke University Medical Center, Department of Pharmacology, Durham, North Carolina 27710
    Fundam Appl Toxicol 14:191-8. 1990
    ..In summary, triallate, a thiocarbamate, did not produce neurotoxicity which has been previously reported for some dithiocarbamates...
  79. ncbi Protease activity in brain, nerve, and muscle of hens given neuropathy-inducing organophosphates and a calcium channel blocker
    H A El-Fawal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg 24061
    Toxicol Appl Pharmacol 103:133-42. 1990
    ..This indicates that calcium channel blockers may contribute to amelioration of organophosphate-induced delayed neuropathy by attenuation of calcium-mediated disruption of axonal and muscle cytoskeletal homeostasis...
  80. ncbi Absorption, distribution, excretion and metabolism of a single oral dose of [14C]tri-o-cresyl phosphate (TOCP) in the male rat
    M B Abou-Donia
    Department of Pharmacology, Duke University Medical Center, Durham, NC 27710
    Toxicology 65:61-74. 1990
    ..This study supports the hypothesis that the insensitivity of the rat to TOCP-induced delayed neurotoxicity may be attributed, in part, to the disposition and metabolism of this chemical...
  81. ncbi First-pass metabolism of inspired ethyl acetate in the upper respiratory tracts of the F344 rat and Syrian hamster
    J B Morris
    Toxicology Program, School of Pharmacy, University of Connecticut, Storrs 06268
    Toxicol Appl Pharmacol 102:331-45. 1990
    ....
  82. ncbi Comparative metabolism and disposition of ethyl carbamate (urethane) in male Fischer 344 rats and male B6C3F1 mice
    A A Nomeir
    Systemic Toxicology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709
    Toxicol Appl Pharmacol 97:203-15. 1989
    ..This work indicates that a number of studies of EC carcinogenicity have used doses that exceed the capacity of rats and mice to metabolize this chemical in a linear fashion...
  83. ncbi Bismuth modified carbon-based electrodes for the determination of selected neonicotinoid insecticides
    Valéria Guzsvány
    Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg D Obradovica 3, 21000 Novi Sad, Serbia
    Molecules 16:4451-66. 2011
    ..4%. To get a deeper insight into the morphology of the bismuth-based sensor surfaces, scanning electron microscopic measurements were performed of both the surface film and the bulk modified electrodes...
  84. pmc Reaction of cresyl saligenin phosphate, the organophosphorus agent implicated in aerotoxic syndrome, with human cholinesterases: mechanistic studies employing kinetics, mass spectrometry, and X-ray structure analysis
    Eugenie Carletti
    Laboratoire de Biophysique Moléculaire, Institut de Biologie Structurale, 41 rue Jules Horowitz, 38027 Grenoble, France
    Chem Res Toxicol 24:797-808. 2011
    ..The crystal structure of CBDP-inhibited BChE confirmed that the phosphate adduct is the ultimate aging product. CBDP is the first organophosphorus agent that leads to a fully dealkylated phospho-serine BChE adduct...
  85. ncbi Antibodies to neural proteins in organophosphorus-induced delayed neuropathy (OPIDN) and its amelioration
    Hassan A N El-Fawal
    Neurotoxicology Laboratory, Division of Health Professions and Natural Sciences, Mercy College, Dobbs Ferry, NY 10522, USA
    Neurotoxicol Teratol 30:161-6. 2008
    ..Together with biomarkers of exposure neuroantibodies can be used to monitor neuropathogenesis due to environmental or occupational exposures...
  86. ncbi Time-dependent changes of lipid peroxidation and antioxidative status in nerve tissues of hens treated with tri-ortho-cresyl phosphate (TOCP)
    Li Ping Zhang
    Department of Preventive Medicine, Weifang Medical University, Shangdong, Weifang, PR China
    Toxicology 239:45-52. 2007
    ....
  87. ncbi Acute oral toxicity of insect repellent N,N-diethylphenylacetamide in mice, rats and rabbits and protective effect of sodium pentobarbital
    S S Rao
    Biochemistry Division, Defence R and D Establishment, Gwalior, India
    Indian J Exp Biol 31:755-60. 1993
    ..The CNS depressant action of SPB may be a crucial factor in protection of rats from DEPA poisoning...
  88. ncbi [The use of probit-method for an estimation of toxic effects of combined toxicants at low concentration levels]
    N A Loshadkin
    Military University of Radiation, Chemical and Biological Defense Dept of Defense of Russian Federation, Moscow
    Radiats Biol Radioecol 43:337-40. 2003
    ....
  89. ncbi [Determination method of tricresyl phosphate in polyvinyl chloride]
    Motoh Mutsuga
    National Institute of Health Sciences 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Shokuhin Eiseigaku Zasshi 44:26-31. 2003
    ..This method was applied to products including 3.1, 6.6 and 8.8% TCP and the recoveries of TCP were 87.3-91.4%. This method is very simple, and it seems suitable for a regulatory test...
  90. ncbi Genotoxicity of neurotoxic triaryl phosphates: identification of DNA adducts of the ultimate metabolites, saligenin phosphates
    A Mentzschel
    Institut fur Toxikologie, Universitat Wurzburg, Federal Republic of Germany
    Chem Res Toxicol 6:294-301. 1993
    ..DNA adducts are formed by an o-hydroxybenzylation from cyclic phosphoranes derived from o-alkyl-substituted triaryl phosphates.(ABSTRACT TRUNCATED AT 250 WORDS)..
  91. ncbi Effect of tri-ortho-cresyl phosphate on hen nervous system
    S Biswas
    Department of Biochemistry, Calcutta University College of Science
    Indian J Med Res 98:96-101. 1993
    ....
  92. ncbi Elucidation of the rapid in vivo metabolism of arecoline
    T A Patterson
    College of Pharmacy, University of South Carolina, Columbia 29208
    Gen Pharmacol 24:641-7. 1993
    ..4. ISO-OMPA significantly inhibited ARE metabolism by purified porcine liver carboxylesterase. 5. The data suggest that carboxylesterase (EC 3.1.1.1) is primarily responsible for the metabolism of ARE in the mouse...
  93. ncbi Subchronic delayed neurotoxicity evaluation of jet engine lubricants containing phosphorus additives
    W Daughtrey
    Exxon Biomedical Sciences, Inc, East Millstone, New Jersey 08875 2350, USA
    Fundam Appl Toxicol 32:244-9. 1996
    ....
  94. ncbi Optimal conduct of the neuropathology evaluation of organophosphorus induced delayed neuropathy in hens
    G J Krinke
    Crop Protection Toxicology, Ciba Geigy AG, Basel, Switzerland
    Exp Toxicol Pathol 49:451-8. 1997
    ..In the hen nervous system, examination of the most susceptible areas, especially the rostral cerebellar lobules, appears to be suitable for detection of any kind of organophosphorus induced, delayed neuropathy...
  95. ncbi Differential inhibition of hepatic, pancreatic, and plasma fatty acid ethyl ester synthase by tri-o-tolylphosphate in rats
    Kelly A Mericle
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Toxicol Appl Pharmacol 179:119-25. 2002
    ..We conclude that fatty acid ethyl or methyl ester synthesizing enzyme(s) in the liver and plasma, which are inhibited by TOTP, are different from that present in the pancreas...
  96. ncbi Cholinesterase activity in quails of neuropathy caused by organophosphates
    H Kinebuchi
    Department of Environmental and Occupational Health, Kochi Medical School, Japan
    Ind Health 36:376-9. 1998
    ....
  97. ncbi Delayed neuropathy and inhibition of soluble neuropathy target esterase following the administration of organophosphorus compounds to hens
    Y Tian
    Department of Public Health, School of Medicine, Mie University, Tsu, Japan
    Tohoku J Exp Med 185:161-71. 1998
    ..Thus, practical and useful NTE measurements should identify the peak inhibition and period inhibition in several nervous tissue regions...
  98. ncbi Brainstem axolemmal protein phosphorylation in vitro in hens dosed with di-1-butyl-2,2-dichlorovinyl phosphate
    D J Huggins
    Department of Environmental and Industrial Health, School of Public Health, University of Michigan, Ann Arbor 48109 2029, USA
    J Toxicol Environ Health A 56:263-82. 1999
    ....
  99. ncbi [The mechanism of the transport of organophosphorus compounds across the histo-hematic barriers]
    V N Miroshkina
    Laboratory of Toxicology, City Laboratory Center, St Petersburg, Russia
    Eksp Klin Farmakol 62:48-51. 1999
    ..It is suggested that both the rate and direction of OPC diffusion are determined by the relationship between the values of affinity of the ligands for the sites of their specific binding found on both sides of the HHB...
  100. ncbi Comparison of neurotoxic effects and potential risks from oral administration or ingestion of tricresyl phosphate and jet engine oil containing tricresyl phosphate
    C R Mackerer
    Product Stewardship and Toxicology, Mobil Business Resources Corporation, Paulsboro, New Jersey 08066, USA
    J Toxicol Environ Health A 57:293-328. 1999
    ..There is no record of a JEO formulated with the modern "conventional" TCP causing human neurotoxicity...
  101. ncbi Reproductive toxicity of butylated triphenyl phosphate and tricresyl phosphate fluids in F344 rats
    J R Latendresse
    Naval Medical Research Institute Toxicology Detachment, Wright Patterson Air Force Base, Ohio 45433
    Fundam Appl Toxicol 22:392-9. 1994
    ..Only TCP-dosed male rats had significantly decreased testicular and epididymal weights.(ABSTRACT TRUNCATED AT 250 WORDS)..

Research Grants1

  1. Structure and Function of the Human PON1 Polymorphism
    Clement E Furlong; Fiscal Year: 2013
    ..Data from transgenic PON1 mouse pedigrees are consistent with this additional level of regulation. ..