fosfomycin

Summary

Summary: An antibiotic produced by Streptomyces fradiae.

Top Publications

  1. pmc Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
    Oliver Laule
    Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:6866-71. 2003
  2. pmc Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 10:R21. 2009
  3. pmc Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection
    Bruce C Trapnell
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Respir Crit Care Med 185:171-8. 2012
  4. pmc In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
    Andrea J McCoy
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bacteriol 185:1218-28. 2003
  5. ncbi Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation
    A Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 16:184-6. 2010
  6. ncbi Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification
    S Fujisaki
    Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
    Gene 175:83-7. 1996
  7. ncbi The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin
    Marc Clastre
    EA2106 Biomolécules et Biotechnologies Végétales, UFR Sciences Pharmaceutiques, Universite de Tours, 37200 Tours, France
    Exp Parasitol 116:375-84. 2007
  8. pmc Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
    Amanda C Brown
    Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    BMC Microbiol 8:78. 2008
  9. ncbi Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms
    Anna Marchese
    Sezione di Microbiologia, Di S C A T, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 22:95-100. 2003
  10. ncbi In vitro activity of fosfomycin against ciprofloxacin-resistant or extended-spectrum beta-lactamase-producing Escherichia coli isolated from urine and blood
    Kwan Soo Ko
    Asian Pacific Research Foundation for Infectious Diseases, Seoul 135 710, Korea
    Diagn Microbiol Infect Dis 58:111-5. 2007

Detail Information

Publications255 found, 100 shown here

  1. pmc Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana
    Oliver Laule
    Torrey Mesa Research Institute, 3115 Merryfield Row, San Diego, CA 92121, USA
    Proc Natl Acad Sci U S A 100:6866-71. 2003
    ..The lack of correlation between gene expression patterns and the accumulation of isoprenoid metabolites indicates that posttranscriptional processes may play an important role in regulating flux through isoprenoid metabolic pathways...
  2. pmc Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum
    Neekesh V Dharia
    Department of Cell Biology, ICND 202, The Scripps Research Institute, North Torrey Pines Road, La Jolla, CA 92037, USA
    Genome Biol 10:R21. 2009
    ....
  3. pmc Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection
    Bruce C Trapnell
    Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Respir Crit Care Med 185:171-8. 2012
    b>Fosfomycin/tobramycin for inhalation (FTI), a unique, broad-spectrum antibiotic combination, may have therapeutic potential for patients with cystic fibrosis (CF).
  4. pmc In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance
    Andrea J McCoy
    Department of Microbiology and Immunology, F Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814 4799, USA
    J Bacteriol 185:1218-28. 2003
    ..In E. coli, the same mutation has previously been shown to cause resistance to fosfomycin, a potent antibiotic that specifically targets MurA...
  5. ncbi Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation
    A Michalopoulos
    Intensive Care Unit, Henry Dunant Hospital, Athens, Greece
    Clin Microbiol Infect 16:184-6. 2010
    ..Adult ICU patients who received intravenous fosfomycin were prospectively examined to assess its safety and effectiveness as an adjunct to the antimicrobial therapy of ..
  6. ncbi Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification
    S Fujisaki
    Department of Biomolecular Science, Faculty of Science, Toho University, Chiba, Japan
    Gene 175:83-7. 1996
    ..These results suggest that Fsr does not have any direct effect on the biosynthesis of isoprenoid in E. coli, and that the mechanism for FsR involves the efflux of the drug by a process that is facilitated by Fsr...
  7. ncbi The methylerythritol phosphate pathway for isoprenoid biosynthesis in coccidia: presence and sensitivity to fosmidomycin
    Marc Clastre
    EA2106 Biomolécules et Biotechnologies Végétales, UFR Sciences Pharmaceutiques, Universite de Tours, 37200 Tours, France
    Exp Parasitol 116:375-84. 2007
    ..tenella and T. gondii growth in vitro. The drug was poorly effective even at high concentrations. Thus, both fosmidomycin sensitivity and isoprenoid metabolism differs substantially between apicomplexan species...
  8. pmc Dxr is essential in Mycobacterium tuberculosis and fosmidomycin resistance is due to a lack of uptake
    Amanda C Brown
    Institute for Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, UK
    BMC Microbiol 8:78. 2008
    ..The fact that there is no glpT homologue in the M. tuberculosis genome and the highly impervious nature of the hydrophobic mycobacterial cell wall suggests that resistance may be due to a lack of cellular penetration...
  9. ncbi Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms
    Anna Marchese
    Sezione di Microbiologia, Di S C A T, University of Genoa, Genoa, Italy
    Int J Antimicrob Agents 22:95-100. 2003
    Four slime-producing uropathogenic Escherichia coli strains were used to investigate the activity of fosfomycin and N-acetylcysteine (NAC) against biofilms developed on 96-well polystyrene tissue culture plates...
  10. ncbi In vitro activity of fosfomycin against ciprofloxacin-resistant or extended-spectrum beta-lactamase-producing Escherichia coli isolated from urine and blood
    Kwan Soo Ko
    Asian Pacific Research Foundation for Infectious Diseases, Seoul 135 710, Korea
    Diagn Microbiol Infect Dis 58:111-5. 2007
    In this study, we evaluated the in vitro activity of fosfomycin and 7 other comparator agents against 307 Escherichia coli isolates including ciprofloxacin-resistant or extended-spectrum beta-lactamase (ESBL)-producing isolates...
  11. pmc Revealing fosfomycin primary effect on Staphylococcus aureus transcriptome: modulation of cell envelope biosynthesis and phosphoenolpyruvate induced starvation
    Marko Petek
    Department of Biotechnology and Systems Biology, National Institute of Biology, Vecna pot 111, Ljubljana, SI 1000, Slovenia
    BMC Microbiol 10:159. 2010
    ..b>Fosfomycin is a potent irreversible inhibitor of MurA, an enolpyruvyl transferase that uses phosphoenolpyruvate as ..
  12. ncbi Fosfomycin tromethamine as second agent for the treatment of acute, uncomplicated urinary tract infections in adult female patients in The Netherlands?
    B J Knottnerus
    Department of General Practice, Academic Medical Centre, Amsterdam, The Netherlands
    J Antimicrob Chemother 62:356-9. 2008
    ..The third choice is fosfomycin tromethamine for which no current resistance data from The Netherlands are available...
  13. pmc Randomized controlled trial of fosmidomycin-clindamycin versus sulfadoxine-pyrimethamine in the treatment of Plasmodium falciparum malaria
    Sunny Oyakhirome
    Institute for Tropical Medicine, Department for Parasitology, University of Tubingen, Wilhelmstrasse 27, Tubingen, Germany
    Antimicrob Agents Chemother 51:1869-71. 2007
    ..These antimalarials merit further clinical exploration...
  14. ncbi Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations
    Yan Ling
    Laboratory of Molecular Parasitology, Department of Pathobiology and Center for Zoonoses Research, University of Illinois at Urbana Champaign, 2001 South Lincoln Avenue, Urbana, Illinois, 61802, USA
    J Med Chem 48:3130-40. 2005
    ..Overall, these results indicate that alkyl bisphosphonates are promising compounds for further development as agents against Toxoplasma gondii growth, in vivo...
  15. ncbi Diaryl ester prodrugs of FR900098 with improved in vivo antimalarial activity
    A Reichenberg
    Jomaa Pharmaka GmbH, Giessen, Germany
    Bioorg Med Chem Lett 11:833-5. 2001
    ..One diaryl ester prodrug demonstrated efficacy in mice infected with the rodent malaria parasite Plasmodium vinckei comparable to i.p. drug administration...
  16. ncbi Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs
    H Jomaa
    Institute of Biochemistry, Academic Hospital Centre, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Science 285:1573-6. 1999
    ..Both drugs suppressed the in vitro growth of multidrug-resistant P. falciparum strains. After therapy with these drugs, mice infected with the rodent malaria parasite P. vinckei were cured...
  17. pmc A second target of the antimalarial and antibacterial agent fosmidomycin revealed by cellular metabolic profiling
    Baichen Zhang
    Proteomics and Mass Spectrometry Facility, Donald Danforth Plant Science Center, St Louis, Missouri 63132, United States
    Biochemistry 50:3570-7. 2011
    ..This work has validated fosmidomycin as a biological reagent for blocking non-mevalonate isoprenoid metabolism and suggests a second in vivo target for fosmidomycin within isoprenoid biosynthesis, in two evolutionarily diverse pathogens...
  18. ncbi Other antimicrobials of interest in the era of extended-spectrum beta-lactamases: fosfomycin, nitrofurantoin and tigecycline
    J Garau
    Department of Medicine, Hospital Mutua de Terrassa, University of Barcelona, Barcelona, Spain
    Clin Microbiol Infect 14:198-202. 2008
    ..The activity and potential use of two old antimicrobials, nitrofurantoin and fosfomycin, and the new compound tigecycline for treatment of infections due to ESBL-producing Enterobacteriaceae, with ..
  19. pmc Fosfomycin-daptomycin and other fosfomycin combinations as alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus
    C Garrigós
    Laboratory of Experimental Infection, Infectious Diseases Service, IDIBELL, Hospital Universitari de Bellvitge, Barcelona, Spain
    Antimicrob Agents Chemother 57:606-10. 2013
    The efficacy of daptomycin, imipenem, or rifampin with fosfomycin was evaluated and compared with that of daptomycin-rifampin in a tissue cage model infection caused by methicillin-resistant Staphylococcus aureus (MRSA)...
  20. pmc Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms
    Elizabeth A Neuner
    Department of Pharmacy, Cleveland Clinic, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 56:5744-8. 2012
    b>Fosfomycin has shown promising in vitro activity against multidrug-resistant (MDR) urinary pathogens; however, clinical data are lacking...
  21. pmc Identification and characterization of new inhibitors of the Escherichia coli MurA enzyme
    E Z Baum
    The R W Johnson Pharmaceutical Research Institute, Raritan, New Jersey 08869, USA
    Antimicrob Agents Chemother 45:3182-8. 2001
    ..2 to 0.9 microM, compared to 8.8 microM for the known MurA inhibitor, fosfomycin. The three compounds exhibited MICs of 4 to 32 microg/ml against Staphylococcus aureus; however, the inhibition ..
  22. ncbi Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions
    Gerard McCaughey
    CF and Airways Microbiology Research Group, Queen s University Belfast, United Kingdom
    J Cyst Fibros 11:163-72. 2012
    ..There is a need for new antibiotics or combination of antibiotics that possess activity against increasingly resistant cystic fibrosis (CF) respiratory pathogens such as Pseudomonas aeruginosa and MRSA...
  23. ncbi Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster
    Ryan D Woodyer
    Department of Chemistry, University of Illinois at Urbana Champaign, 600 S Mathews Avenue, Urbana, Illinois 61801, USA
    Chem Biol 13:1171-82. 2006
    b>Fosfomycin is a clinically utilized, highly effective antibiotic, which is active against methicillin- and vancomycin-resistant pathogens...
  24. pmc Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes
    Jun ichi Wachino
    Department of Bacteriology II, National Institute of Infectious Diseases, 4 7 1 Gakuen, Musashi Murayama, Tokyo 208 0011, Japan
    Antimicrob Agents Chemother 54:3061-4. 2010
    We evaluated the in vitro activity of fosfomycin against a total of 192 CTX-M beta-lactamase-producing Escherichia coli strains isolated in 70 Japanese clinical settings. Most of the isolates (96...
  25. ncbi Synergistic effect of fosfomycin and arbekacin on a methicillin-resistant Staphylococcus aureus-induced biofilm in a rat model
    Keiko Morikawa
    Division of Clinical Nutrition, Department of Nutrition, Sagami Women s University, 2 1 1 Bunkyo, Sagamihara, Kanagawa 228 8533, Japan
    Int J Antimicrob Agents 25:44-50. 2005
    ..model, methicillin-resistant Staphylococcus aureus (MRSA) growing as a biofilm was treated with a combination of fosfomycin (FOM) and arbekacin (ABK) or by the agents alone...
  26. ncbi Kinetics, stoichiometry, and identification of the reactive thiolate in the inactivation of UDP-GlcNAc enolpyruvoyl transferase by the antibiotic fosfomycin
    J L Marquardt
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115
    Biochemistry 33:10646-51. 1994
    b>Fosfomycin [(1R,2S)-1,2-epoxypropylphosphonic acid] has been shown to exert its antibiotic effect through the inhibition of UDP-GlcNAc enolpyruvoyl transferase [Kahan, F. M., et al. (1974) Ann. N.Y. Acad. Sci...
  27. pmc Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Cell 16:144-56. 2004
    ....
  28. ncbi Fosfomycin versus other antibiotics for the treatment of cystitis: a meta-analysis of randomized controlled trials
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Antimicrob Chemother 65:1862-77. 2010
    ..Cystitis is a common infection. The alarmingly high resistance rates exhibited by contemporary uropathogens necessitate the re-evaluation of old antibiotics...
  29. ncbi Identification of a novel fosfomycin resistance gene (fosA2) in Enterobacter cloacae from the Salmon River, Canada
    H Xu
    State Key Laboratory of Microbial Technology, Shandong University, Jinan, Shandong, China
    Lett Appl Microbiol 52:427-9. 2011
    To investigate the occurrence of fosfomycin-resistant (fos(R) ) bacteria in aquatic environments.
  30. ncbi Prevalence of acquired fosfomycin resistance among extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae clinical isolates in Korea and IS26-composite transposon surrounding fosA3
    So Young Lee
    Department of Laboratory Medicine, College of Medicine, Catholic University of Korea, Seoul, Korea
    J Antimicrob Chemother 67:2843-7. 2012
    To investigate the prevalence of plasmid-mediated fosfomycin resistance determinants among extended-spectrum β-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae and their genetic environments.
  31. ncbi Fosfomycin: an old--new antibiotic
    R Raz
    Infectious Diseases Unit, Ha Emek Medical Centre, Afula, Israel
    Clin Microbiol Infect 18:4-7. 2012
    b>Fosfomycin is a broad-spectrum antibiotic discovered in Spain in 1969. It has bactericidal activity against a wide range of bacteria, including gram-negative micro-organisms and some gram-positive bacteria, such as staphylococci...
  32. ncbi Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens
    Drosos E Karageorgopoulos
    Alfa Institute of Biomedical Sciences, Athens, Greece
    J Antimicrob Chemother 67:255-68. 2012
    b>Fosfomycin has attracted renewed interest for the treatment of lower urinary tract and even systemic infections caused by Gram-negative pathogens with resistance to traditionally used agents...
  33. ncbi Effect of antimicrobial agents, especially fosfomycin, on the production and release of Vero toxin by enterohaemorrhagic Escherichia coli O157:H7
    M Yoh
    Laboratory for Culture Collections, Osaka University, Japan
    FEMS Immunol Med Microbiol 19:57-64. 1997
    ..9%) received antimicrobial agents as treatments, in particular, fosfomycin comprised 84.0% of the prescribed treatment...
  34. pmc Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs
    Eugene Uh
    Department of Chemistry, George Washington University, Washington, DC 20052, USA
    Bioorg Med Chem Lett 21:6973-6. 2011
    ..Our results show that this strategy can be an effective way for improving whole cell activity of NMP inhibitors...
  35. ncbi Randomized prospective comparison of fosfomycin and cefotiam for prevention of postoperative infection following urological surgery
    Kazuhiro Ishizaka
    Department of Urology, Kanto Central Hospital, 6 25 1 Kamiyoga, Setagaya Ku, Tokyo 158 8531, Japan
    J Infect Chemother 13:324-31. 2007
    A randomized study design was used to compare the efficacy of cefotiam (CTM) and fosfomycin (FOM) for preventing infection associated with urologic surgery...
  36. ncbi Fosmidomycin for malaria
    Michel A Missinou
    Medical Research Unit, Albert Schweitzer Hospital, Lambarene, Gabon
    Lancet 360:1941-2. 2002
    ..These data suggest that fosmidomycin is a safe and effective treatment for uncomplicated malaria if given for 4 days or more...
  37. ncbi Fosmidomycin resistance in adenylate cyclase deficient (cya) mutants of Escherichia coli
    Yoshiko Sakamoto
    Department of Food Science and Technology, College of Bioresouce Sciences, Nihon University, Fujisawa, Kanagawa, Japan
    Biosci Biotechnol Biochem 67:2030-3. 2003
    ..were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin...
  38. ncbi Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus
    Makoto Kuroda
    Bacteriology, Juntendo University, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Mol Microbiol 49:807-21. 2003
    ..aureus showed significant decrease of resistance against teicoplanin, beta-lactam, bacitracin and fosfomycin but not of D-cycloserine and levofloxacin...
  39. ncbi Properties and inhibition of the first two enzymes of the non-mevalonate pathway of isoprenoid biosynthesis
    C Mueller
    Botanical Institute II, University of Karlsruhe, Kaiserstr 12, D 76128 Karlsruhe, Germany
    Biochem Soc Trans 28:792-3. 2000
    ..The DXR of plants, isolated from barley seedlings, shows a pH optimum of 8.1, which is typical for enzymes active in the chloroplast stroma...
  40. pmc 1-Deoxy-D-xylulose 5-phosphate reductoisomerase (IspC) from Mycobacterium tuberculosis: towards understanding mycobacterial resistance to fosmidomycin
    Rakesh K Dhiman
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Bacteriol 187:8395-402. 2005
    ..Thus, M. tuberculosis resistance to fosmidomycin is not due to intrinsic properties of Rv2870c, and the enzyme appears to be a valid drug target in this pathogen...
  41. pmc In vitro interactions of antimicrobial combinations with fosfomycin against KPC-2-producing Klebsiella pneumoniae and protection of resistance development
    Maria Souli
    4th Department of Internal Medicine, Athens University School of Medicine, University General Hospital Attikon, 1 Rimini Str, 124 62 Chaidari, Greece
    Antimicrob Agents Chemother 55:2395-7. 2011
    Using time-kill methodology, we investigated the interactions of fosfomycin with meropenem or colistin or gentamicin against 17 genetically distinct Klebsiella pneumoniae clinical isolates carrying blaKPC-2...
  42. pmc Biological costs and mechanisms of fosfomycin resistance in Escherichia coli
    Annika I Nilsson
    Department of Bacteriology, Swedish Institute for Infectious Disease Control, S 171 82 Stockholm, Sweden
    Antimicrob Agents Chemother 47:2850-8. 2003
    b>Fosfomycin is a cell wall inhibitor used mainly for the treatment of uncomplicated lower urinary tract infections...
  43. ncbi Design, synthesis, and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Mounir Andaloussi
    Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry, Uppsala University, Biomedical Center, Box 574, SE 751 23 Uppsala, Sweden
    J Med Chem 54:4964-76. 2011
    ....
  44. ncbi Fosfomycin: an old, new friend?
    M Popovic
    Department of Cardiovascular and Interventional Radiology, Medical University of Vienna, Vienna, Austria
    Eur J Clin Microbiol Infect Dis 29:127-42. 2010
    b>Fosfomycin (FOM) is an antibiotic which has varying application indications across the globe...
  45. ncbi The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
    ..Current efforts should eventually contribute to an effective drug designed to fight against microbial pathogens that show resistance to currently available agents...
  46. pmc The glycerol-3-phosphate permease GlpT is the only fosfomycin transporter in Pseudomonas aeruginosa
    Alfredo Castañeda-García
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Bacteriol 191:6968-74. 2009
    b>Fosfomycin is transported into Escherichia coli via both glycerol-3-phosphate (GlpT) and a hexose phosphate transporter (UhpT). Consequently, the inactivation of either glpT or uhpT confers increased fosfomycin resistance in this species...
  47. pmc Kinetic characterization and phosphoregulation of the Francisella tularensis 1-deoxy-D-xylulose 5-phosphate reductoisomerase (MEP synthase)
    Safdar Jawaid
    Department of Chemistry and Biochemistry, George Mason University, Manassas, Virginia, United States of America
    PLoS ONE 4:e8288. 2009
    ..tularensis MEP pathway. Overall, our study suggests that MEP synthase is an excellent target for the development of novel antibiotics against F. tularensis...
  48. ncbi Acyloxyalkyl ester prodrugs of FR900098 with improved in vivo anti-malarial activity
    Regina Ortmann
    Department für Pharmazie, Ludwig Maximilians Universitat Munchen, Butenandtstrasse 5 13, D 81377, Munchen, Germany
    Bioorg Med Chem Lett 13:2163-6. 2003
    ..The most successful compound demonstrated 2-fold increased activity in mice infected with the rodent malaria parasite Plasmodium vinckei...
  49. pmc In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin
    Andrea Endimiani
    Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Antimicrob Agents Chemother 54:526-9. 2010
    In vitro activity of fosfomycin was evaluated against 68 bla(KPC)-possessing Klebsiella pneumoniae (KpKPC) isolates, including 23 tigecycline- and/or colistin-nonsusceptible strains...
  50. ncbi Evaluation of fosmidomycin analogs as inhibitors of the Synechocystis sp. PCC6803 1-deoxy-D-xylulose 5-phosphate reductoisomerase
    Youn Hi Woo
    Department of Pharmaceutical Sciences, College of Pharmacy, Pharmacy Bldg Rm 203, Oregon State University, Corvallis, OR 97331 3507, USA
    Bioorg Med Chem 14:2375-85. 2006
    ..PCC6803 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR). Fosfoxacin, the phosphate analog of fosmidomycin, and its acetyl congener were found to be more potent inhibitors of DXR than fosmidomycin...
  51. ncbi Fosfomycin: use beyond urinary tract and gastrointestinal infections
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Clin Infect Dis 46:1069-77. 2008
    ..A search of the literature was performed to compile relevant evidence regarding the effectiveness and safety of fosfomycin for the treatment of patients with gram-positive and/or gram-negative bacterial infections (excluding urinary ..
  52. ncbi Fosfomycin suppresses RS-virus-induced Streptococcus pneumoniae and Haemophilus influenzae adhesion to respiratory epithelial cells via the platelet-activating factor receptor
    Shin Ichi Yokota
    Department of Microbiology, Sapporo Medical University School of Medicine, South 1 West 17, Chuo Ku, Sapporo, Japan
    FEMS Microbiol Lett 310:84-90. 2010
    ..b>Fosfomycin, an antimicrobial agent, significantly suppressed PAF receptor induction by RSV infection at the mRNA and cell ..
  53. pmc Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis
    David L MacLeod
    Gilead Sciences, Inc, Seattle, WA 98121, USA
    J Antimicrob Chemother 64:829-36. 2009
    To compare the in vitro and in vivo activities of a 4:1 (w/w) fosfomycin/tobramycin combination (FTI) with those of fosfomycin and tobramycin alone against cystic fibrosis (CF) and non-CF bronchiectasis pathogens.
  54. pmc A phosphonate-induced gene which promotes Penicillium-mediated bioconversion of cis-propenylphosphonic acid to fosfomycin
    M Watanabe
    Pharmaceutical Technology Laboratories, Meiji Seika Kaisha, Ltd, 788 Kayama, Odawara shi 250, Japan
    Appl Environ Microbiol 65:1036-44. 1999
    Penicillium decumbens is able to epoxidize cis-propenylphosphonic acid (cPA) to produce the antibiotic fosfomycin [FOM; also referred to as phosphonomycin and (-)-cis-1,2-epoxypropylphosphonic acid], a bioconversion of considerable ..
  55. ncbi Role of ciprofloxacin in its synergistic effect with fosfomycin on drug-resistant strains of Pseudomonas aeruginosa
    Sakuo Yamada
    Department of Microbiology, Kawasaki Medical School, Okayama, Japan
    Chemotherapy 53:202-9. 2007
    The aim of this study was to investigate the synergistic effect of ciprofloxacin (CPFX) and fosfomycin (FOM) on CPFX-resistant Pseudomonas aeruginosa strains.
  56. ncbi Antimicrobial susceptibilities of urinary extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae to fosfomycin and nitrofurantoin in a teaching hospital in Taiwan
    Hsin yi Liu
    Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
    J Microbiol Immunol Infect 44:364-8. 2011
    ..The role of fosfomycin in the era of growing bacteria resistance has been widely discussed recently...
  57. ncbi Synergy of fosfomycin with other antibiotics for Gram-positive and Gram-negative bacteria
    Antonia C Kastoris
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Eur J Clin Pharmacol 66:359-68. 2010
    ..b>Fosfomycin shows no cross-resistance to other antibiotic classes...
  58. ncbi Antimicrobial susceptibility of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Enterobacteriaceae isolates to fosfomycin
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 35:240-3. 2010
    ..We sought to evaluate the in vitro antimicrobial activity of fosfomycin against multidrug-resistant (MDR) Enterobacteriaceae isolates...
  59. pmc Daptomycin, fosfomycin, or both for treatment of methicillin-resistant Staphylococcus aureus osteomyelitis in an experimental rat model
    W Poeppl
    Department of Internal Medicine I, Division of Infectious Diseases, Medical University of Vienna, Vienna, Austria
    Antimicrob Agents Chemother 55:4999-5003. 2011
    The in vivo activities of daptomycin, fosfomycin, and a combination of both antibiotics against a clinical isolate of methicillin-resistant Staphylococcus aureus (daptomycin MIC, 0.25 μg/ml; fosfomycin MIC, 0...
  60. ncbi Single-dose pharmacokinetics of fosfomycin during continuous venovenous haemofiltration
    Rainer Gattringer
    Department of Internal Medicine I, Division of Infectious Diseases and Chemotherapy, Medical University of Vienna Vienna, Austria
    J Antimicrob Chemother 58:367-71. 2006
    Dosage recommendations for fosfomycin are available for haemodialysed patients but there are no data for patients undergoing continuous renal replacement therapy...
  61. ncbi Disodium-fosfomycin pharmacokinetics and bioavailability in post weaning piglets
    A L Soraci
    Área Toxicología, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Tandil, Argentina
    Res Vet Sci 90:498-502. 2011
    Disodium-fosfomycin pharmacokinetics has been studied in different species after oral, intravenous, intramuscular and subcutaneous administration...
  62. ncbi [Fosfomycin]
    M Gobernado
    Servicio de Microbiologia, Hospital La Fe, Avda Campanar 21, 46009 Valencia, Spain
    Rev Esp Quimioter 16:15-40. 2003
    b>Fosfomycin is an natural antibiotic with an epoxide structure and low molecular weight which acts in the first stage of peptidoglycan synthesis of the bacterial wall...
  63. ncbi Mechanistic studies of HPP epoxidase: configuration of the substrate governs its enzymatic fate
    Zongbao Zhao
    Division of Medicinal Chemistry, College of Pharmacy, Department of Chemistry and Biochemistry, University of Texas, Austin, TX 78712, USA
    Angew Chem Int Ed Engl 41:4529-32. 2002
  64. ncbi Cloning and nucleotide sequence of fosfomycin biosynthetic genes of Streptomyces wedmorensis
    T Hidaka
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
    Mol Gen Genet 249:274-80. 1995
    The biosynthetic pathway for production of the antibiotic fosfomycin by Streptomyces wedmorensis consists of four steps including the formation of a C-P bond and an epoxide. Fosfomycin production genes were cloned from genomic DNA using S...
  65. ncbi Activity and penetration of fosfomycin, ciprofloxacin, amoxicillin/clavulanic acid and co-trimoxazole in Escherichia coli and Pseudomonas aeruginosa biofilms
    Jose M Rodríguez-Martínez
    Int J Antimicrob Agents 30:366-8. 2007
  66. ncbi Structure of UDP-N-acetylglucosamine enolpyruvyl transferase, an enzyme essential for the synthesis of bacterial peptidoglycan, complexed with substrate UDP-N-acetylglucosamine and the drug fosfomycin
    T Skarzynski
    Glaxo Wellcome Research and Development, Medicines Research Centre, Stevenage, UK ts
    Structure 4:1465-74. 1996
    ..catalyses the first committed step of bacterial cell wall biosynthesis and is a target for the antibiotic fosfomycin. The only other known enolpyruvyl transferase is 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase, an enzyme ..
  67. pmc Heteroresistance to fosfomycin is predominant in Streptococcus pneumoniae and depends on the murA1 gene
    Hansjürg Engel
    Institute for Infectious Diseases, Faculty of Medicine, University of Bern, Bern, Switzerland
    Antimicrob Agents Chemother 57:2801-8. 2013
    b>Fosfomycin targets the first step of peptidoglycan biosynthesis in Streptococcus pneumoniae catalyzed by UDP-N-acetylglucosamine enolpyruvyltransferase (MurA1). We investigated whether heteroresistance to fosfomycin occurs in S...
  68. ncbi Comparative X-ray analysis of the un-liganded fosfomycin-target murA
    S Eschenburg
    Max Planck Institute for Medical Research, Department of Biophysics, Heidelberg, Germany
    Proteins 40:290-8. 2000
    ..The homogeneous population with L-isoaspartate in both structures suggests that the modification in Enterobacter cloacae MurA is not a mere aging defect but rather the result of a specific in vivo process...
  69. ncbi [Fosfomycin prescription during production shortage]
    A Dinh
    Service des Maladies Infectieuses et Tropicales, Hopital Raymond Poincare, AP HP, Universite de Versailles Saint Quentin en Yvelines, 104, Boulevard Raymond Poincare, 92380 Garches, France
    Med Mal Infect 38:383-6. 2008
    The supply of fosfomycin had to be carefully controlled over metropolitan France during 10 weeks because of a unique crisis in production. Three hundred and forty prescriptions were collected and re-examined by an expert committee...
  70. pmc The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase
    Mark F Mabanglo
    Department of Chemistry, University of Utah, Salt Lake City, Utah, United States
    Biochemistry 51:917-25. 2012
    ..This enzyme is highly homologous to fosfomycin kinase (FomA), an antibiotic resistance enzyme found in a few strains of Streptomyces and Pseudomonas whose mode ..
  71. pmc Activities of fosfomycin, tigecycline, colistin, and gentamicin against extended-spectrum-β-lactamase-producing Escherichia coli in a foreign-body infection model
    Stéphane Corvec
    Service of Infectious Diseases, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
    Antimicrob Agents Chemother 57:1421-7. 2013
    ..We compared the activities of fosfomycin, tigecycline, colistin, and gentamicin (alone and in combination) against a CTX-M15-producing strain of ..
  72. ncbi In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus
    J M Sahuquillo Arce
    Department of Clinical Microbiology, Hospital La Fe, Avda Campanar 21, 46009 Valencia, Spain
    Rev Esp Quimioter 19:252-7. 2006
    ..to investigate the in vitro effects of linezolid combined with five antistaphylococcal antibiotics--doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin--upon methicillin-susceptible Staphylococcus aureus (MSSA)...
  73. ncbi Fosfomycin for the treatment of multidrug-resistant, including extended-spectrum beta-lactamase producing, Enterobacteriaceae infections: a systematic review
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences, Athens, Greece
    Lancet Infect Dis 10:43-50. 2010
    ..We evaluated the evidence on fosfomycin as a treatment option for infections caused by members of the family Enterobacteriaceae with advanced resistance ..
  74. doi Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase from Haemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin
    Hye Jin Yoon
    Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Proteins 71:1032-7. 2008
  75. pmc High-dose daptomycin plus fosfomycin is safe and effective in treating methicillin-susceptible and methicillin-resistant Staphylococcus aureus endocarditis
    Jose M Miro
    Hospital Clinic IDIBAPS, University of Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:4511-5. 2012
    ..endocarditis) who were successfully treated with high-dose intravenous daptomycin (10 mg/kg/day) plus fosfomycin (2 g every 6 h) for 6 weeks...
  76. ncbi Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studies
    Matthew E Falagas
    Alfa Institute of Biomedical Sciences AIBS, Athens, Greece
    Int J Antimicrob Agents 34:111-20. 2009
    ..This mandates the re-evaluation of already existing antibiotics such as fosfomycin. We systematically reviewed the literature to assess the clinical and microbiological effectiveness of ..
  77. ncbi Antimicrobial susceptibility of multidrug-resistant Gram negative bacteria to fosfomycin
    M E Falagas
    Alfa Institute of Biomedical Sciences, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Eur J Clin Microbiol Infect Dis 27:439-43. 2008
    We evaluated the antimicrobial activity of fosfomycin against a randomly selected sample of 30 Klebsiella pneumoniae, 30 Pseudomonas aeruginosa, and 30 Acinetobacter baumannii multidrug-resistant, clinical isolates from patients in a ..
  78. ncbi Synergistic effects of aminoglycosides and fosfomycin on Pseudomonas aeruginosa in vitro and biofilm infections in a rat model
    Yun Cai
    Department of Clinical Pharmacology, PLA General Hospital, Beijing 100853, People s Republic of China
    J Antimicrob Chemother 64:563-6. 2009
    To study the in vitro and in vivo efficacy of aminoglycosides against Pseudomonas aeruginosa, either alone or in combination with fosfomycin.
  79. pmc Plastid cues posttranscriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis
    Susanna Sauret-Güeto
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Physiol 141:75-84. 2006
    ..Regulation of the MEP pathway by a mechanism dependent on plastid cues might function under physiological conditions to finely adjust plastidial isoprenoid biosynthesis to the metabolic capabilities or requirements of plastids...
  80. ncbi [Prophylactic effect of fosfomycin on postoperative infection in gastroenterological surgery]
    Nagao Shinagawa
    Department of Surgery, Nagoya Midori Municipal Hospital
    Jpn J Antibiot 59:417-27. 2006
    b>Fosfomycin (FOM), a drug with unique mechanism of action against bacteria, was prospectively compared with cefmetazole (CMZ) and flomoxef (FMOX) to assess its effectiveness in preventing postoperative infections after upper ..
  81. ncbi gamma-Substituted bis(pivaloyloxymethyl)ester analogues of fosmidomycin and FR900098
    Thomas Kurz
    Institute of Pharmacy, University of Hamburg, Hamburg, Germany
    Arch Pharm (Weinheim) 340:661-6. 2007
    ....
  82. ncbi Fosmidomycin analogues as inhibitors of monoterpenoid indole alkaloid production in Catharanthus roseus cells
    Zoia Mincheva
    EA 3857, Laboratoire de Synthèse et Physicochimie Organique et Thérapeutique SPOT, 31 Avenue Monge, 37200 Tours, France
    Phytochemistry 66:1797-803. 2005
    ..Some of them have greater inhibitory effect than fosmidomycin and fully inhibit alkaloid accumulation at the concentration of 100 microM...
  83. pmc Structural basis of regiospecificity of a mononuclear iron enzyme in antibiotic fosfomycin biosynthesis
    Danny Yun
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 133:11262-9. 2011
    ..the oxidative epoxidation of (S)-2-hydroxypropylphosphonic acid (S-HPP) in the biosynthesis of the antibiotic fosfomycin. Additionally, the enzyme converts the R-enantiomer of the substrate (R-HPP) to 2-oxo-propylphosphonic acid...
  84. ncbi Role of the non-mevalonate pathway in indole alkaloid production by Catharanthus roseus hairy roots
    Seung Beom Hong
    Department of Biochemistry and Cell Biology, Rice University, MS 140, 6100 Main St, Houston, Texas 77005, USA
    Biotechnol Prog 19:1105-8. 2003
    ..These results suggest that the DXP pathway is a major provider of carbon for the monoterpenoid pathway leading to the formation of indole alkaloids in C. roseus hairy roots in the exponential phase...
  85. pmc Fosfomycin enhances the active transport of tobramycin in Pseudomonas aeruginosa
    David L MacLeod
    Gilead Sciences, Inc, Seattle, Washington, USA
    Antimicrob Agents Chemother 56:1529-38. 2012
    ..In these studies, we demonstrate that fosfomycin synergistically enhances the activity of tobramycin in the presence of mucin...
  86. ncbi Pseudomonas aeruginosa fosfomycin resistance mechanisms affect non-inherited fluoroquinolone tolerance
    Valerie N De Groote
    Centre of Microbial and Plant Genetics, KU Leuven, Leuven, Belgium
    J Med Microbiol 60:329-36. 2011
    ..aeruginosa strains that are resistant to the antibiotic fosfomycin due to either of two unrelated fosfomycin resistance mechanisms...
  87. ncbi Synthesis of the antimalarial drug FR900098 utilizing the nitroso-ene reaction
    Andrey A Fokin
    Department of Organic Chemistry, Kiev Polytechnic Institute, pr Pobedy 37, 03056 Kiev, Ukraine
    Org Lett 9:4379-82. 2007
    ..The utilization of dibenzyl allylphosphonate as the starting compound allows one-step hydrogenation with dealkylation, which simplifies the preparative scheme further...
  88. ncbi Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity
    Regina Ortmann
    Department für Pharmazie, Ludwig Maximilians Universitat, Munchen, Germany
    Arch Pharm (Weinheim) 338:305-14. 2005
    ..Prodrugs with increased oral activity in mice infected with the rodent malaria parasite Plasmodium vinckei were obtained by masking the phosphonate moiety of FR900098 as alkoxycarbonyloxyethyl esters...
  89. ncbi Characterization of a Cys115 to Asp substitution in the Escherichia coli cell wall biosynthetic enzyme UDP-GlcNAc enolpyruvyl transferase (MurA) that confers resistance to inactivation by the antibiotic fosfomycin
    D H Kim
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biochemistry 35:4923-8. 1996
    The antibiotic fosfomycin inhibits bacterial cell wall biosynthesis by inactivation of UDP-GlcNAc enolpyruvyl tranferase (MurA)...
  90. pmc Assessing the emergence of resistance: the absence of biological cost in vivo may compromise fosfomycin treatments for P. aeruginosa infections
    Alexandro Rodríguez-Rojas
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 5:e10193. 2010
    b>Fosfomycin is a cell wall inhibitor used efficiently to treat uncomplicated urinary tract and gastrointestinal infections...
  91. ncbi Treatment of experimental cystitis in the rat with a single dose of fosfomycin trometamol
    F Dubini
    Institute of Medical Microbiology, University of Milan, Italy
    Chemioterapia 7:24-8. 1988
    The therapeutic effectiveness of a single oral dose (60 and 200 mg/kg body weight) of fosfomycin trometamol (FT), norfloxacin, trimethoprim sulfamethoxazole (Bactrim) and pipemidic acid against experimental cystitis in the rat were ..
  92. pmc Antimicrobial susceptibilities of commonly encountered bacterial isolates to fosfomycin determined by agar dilution and disk diffusion methods
    Ching Lan Lu
    Department of Internal Medicine, National Taiwan University Hospital, Hsin Chu Branch, Hsin Chu, Taiwan
    Antimicrob Agents Chemother 55:4295-301. 2011
    We studied the antimicrobial activity of fosfomycin against 960 strains of commonly encountered bacteria associated with urinary tract infection using standard agar dilution and disk diffusion methods...
  93. ncbi Synthesis and evaluation of alpha-halogenated analogues of 3-(acetylhydroxyamino)propylphosphonic acid (FR900098) as antimalarials
    Thomas Verbrugghen
    Laboratory for Medicinal Chemistry FFW, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Med Chem 53:5342-6. 2010
    ..These analogues were evaluated for antimalarial potential in vitro against Plasmodium falciparum and in vivo in the P. berghei mouse model. All three analogues showed higher in vitro and/or in vivo potency than the reference compounds...
  94. ncbi Synthesis of alpha-substituted fosmidomycin analogues as highly potent Plasmodium falciparum growth inhibitors
    Timothy Haemers
    Laboratory for Medicinal Chemistry FFW, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium
    Bioorg Med Chem Lett 16:1888-91. 2006
    ..It is approximately three times more potent in inhibiting the growth of P. falciparum than FR900098, the most potent representative of this class reported so far...
  95. ncbi Isoprenoid biosynthesis via the methylerythritol phosphate pathway: structural variations around phosphonate anchor and spacer of fosmidomycin, a potent inhibitor of deoxyxylulose phosphate reductoisomerase
    Catherine Zinglé
    Universite de Strasbourg CNRS, Strasbourg, UMR 7177, Institut Le Bel, 4 rue Blaise Pascal, 67070 Strasbourg, France
    J Org Chem 75:3203-7. 2010
    ..e., sulfonate or carboxylate functionalities. The potential of the synthesized analogues to inhibit the E. coli DXR was evaluated...
  96. pmc Identification of a novel UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) from Vibrio fischeri that confers high fosfomycin resistance in Escherichia coli
    Sanath Kumar
    Department of Biology, Eastern New Mexico University, Portales NM, 88130, USA
    Arch Microbiol 191:425-9. 2009
    ..is a key enzyme involved in bacterial cell wall peptidoglycan synthesis and a target for the antimicrobial agent fosfomycin, a structural analog of the MurA substrate phosphoenol pyruvate...
  97. pmc Fosfomycin suppresses chemokine induction in airway epithelial cells infected with respiratory syncytial virus
    Tamaki Okabayashi
    Department of Microbiology, Sapporo Medical University School of Medicine, S1 W17, Chuou ku, Sapporo, Hokkaido 060 8556, Japan
    Clin Vaccine Immunol 16:859-65. 2009
    ..b>Fosfomycin (FOF) is approved as a treatment for various bacterial infectious diseases, including respiratory infectious ..
  98. ncbi Divergent strategy for the synthesis of alpha-aryl-substituted fosmidomycin analogues
    Vincent Devreux
    Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Belgium
    J Org Chem 72:3783-9. 2007
    ..An alpha-(4-cyanophenyl)fosmidomycin analogue emerged as the most potent analogue in the present series. Its antimalarial activity clearly surpasses that of the reference compound fosmidomycin...
  99. ncbi Effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on Staphylococcus epidermidis biofilms
    Stefan Hajdu
    Department of Trauma Surgery, Medical University of Vienna, Vienna, Austria
    J Orthop Res 27:1361-5. 2009
    ..In the following work, we investigated the effects of vancomycin, daptomycin, fosfomycin, tigecycline, and ceftriaxone on biofilms formed by Staphylococcus epidermidis isolates causative for implant ..
  100. ncbi Synthesis and biological evaluation of cyclopropyl analogues of fosmidomycin as potent Plasmodium falciparum growth inhibitors
    Vincent Devreux
    Laboratory for Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Ghent University, Harelbekestraat 72, B 9000 Gent, Belgium
    J Med Chem 49:2656-60. 2006
    ..coli DOXP reductoisomerase and proved equally active when tested in vitro for P. falciparum growth inhibition. Conversely, the alpha-phenyl cis-cyclopropyl analogue 4 showed virtually no inhibition of the enzyme...
  101. ncbi Fosfomycin nebulizer therapy to chronic sinusitis
    A Kamijyo
    Department of Otolaryngology, Yamanashi Medical University, 1110 Shimokato, Tamaho cho, Nakakoma gun, Yamanashi 409 3898, Japan
    Auris Nasus Larynx 28:227-32. 2001
    effects of Fosfomycin (FOM) nebulizer therapy were studied in patients with chronic sinusitis.

Research Grants25

  1. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2009
    ..b>Fosfomycin is an inexpensive and potent broad-spectrum antibiotic effective against Gram-positive and Gram-negative ..
  2. Chemistry, Structure and Biology of Thiol Transferases
    Richard N Armstrong; Fiscal Year: 2013
    ..the role of bacillithiol (BSH) in the resistance of Gram-positive pathogenic microorganisms to the antibiotic fosfomycin conferred by the enzyme FosB...
  3. Directed evolution of fosfomycin resistance enzymes from a promiscuous progenitor
    Paul D Cook; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Fosfomycin is a safe, broad-spectrum antibiotic that is effective against both Gram-negative and Gram-positive bacteria...
  4. Investigation of unusual cyclization reactions in biocatalysis
    Hung wen Liu; Fiscal Year: 2013
    ..applicant): The ultimate goal of this project is to understand at the molecular level how the oxirane group of fosfomycin, the cyclohexene moiety of spinosyn A, and the annelated oligocyclobutane ring system of ladderane lipids are ..
  5. Overcoming O2 limitations: Reaction of Oxygenases with in situ generated O2
    BENNETT RICHARD STREIT; Fiscal Year: 2013
    ..as others, with the later of these enzymes playing important oxidative roles in the synthesis of the antibiotic fosfomycin (HEPD) and in the synthesis of the neurotransmitter serotonin (TrpH)...
  6. Mechanism of taurine: alpha-ketoglutarate dioxygenase
    Carsten Krebs; Fiscal Year: 2013
    ..of an alcohol to an epoxide, using hydrogen peroxide as the oxidant, in the biosynthesis of the antibiotic, fosfomycin;(2) carbapenem synthase (CarC), which uses one or more tyrosyl radical in concert with the presumptive ferryl ..
  7. Understanding a Mechanism of Antibiotic Resistance by Phosphorylation: Fosfomycin
    SVITLANA PAKHOMOVA; Fiscal Year: 2009
    ..discovered kinases FomA and FomB that represent a novel mechanism of resistance to the widely used antibiotic fosfomycin. These two novel proteins inactivate fosfomycin through phosphorylation...
  8. Characterization of novel MurA inhibitors
    Ernst Schonbrunn; Fiscal Year: 2006
    ..It is the target of the naturally occurring, broad spectrum antibiotic fosfomycin. Fosfomycin, an epoxide, covalently attacks a critical cysteine-residue of MurA (Cys115)...
  9. Mechanistic Studies of a Novel Methyltransferase in Fosfomycin Biosynthesis
    STEVEN MANSOORABADI; Fiscal Year: 2008
    ..mechanism of Fom3, a novel methyltransferase involved in the biosynthesis of the clinically useful antibiotic fosfomycin. Fom3 belongs to a unique class of cobalamin-containing Radical SAM (S-adenosyl-L-methionine) enzymes, which is ..
  10. MICROBIAL METABOLISM OF REDUCED PHOSPHORUS COMPOUNDS
    WILLIAM METCALF; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  11. Genetics of Interstitial Cystitis
    John Warren; Fiscal Year: 2007
    ..The identification of alleles of susceptibility to IC may reveal clues to pathogenesis, clinical therapy, preventive strategy, and possibly gene therapies. ..
  12. MARYLAND INTERSTITIAL CYSTITIS CLINICAL TRIALS GROUP
    John Warren; Fiscal Year: 2003
    ..This group will bring to the IC CTG experienced, motivated, and dedicated investigators; a new cadre of IC patients; and a network of referring urologists/gynecologists to study management strategies for this distressing disease. ..
  13. Conference--Pulmonary Alveolar Proteinosis Research
    Bruce Trapnell; Fiscal Year: 2004
    ..Recent progress in PAP research represents a paradigm of the intersection of basic science, clinical medicine and translational research, which has taken this disease from obscurity to clarity in a decade. ..
  14. A Case Control Study of Interstitial Cystitis
    John Warren; Fiscal Year: 2006
    ..4) That patients with IC have remissions and that certain clinical features, e.g., bacterial cystitis at disease onset, are prognostic factors for remissions. ..
  15. Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2005
    ..This conference will provide a forum where thought leaders focused on the molecular and cellular basis or clinical management of PAP will present cutting edge research, integrate concepts, and chart innovative research directions. ..
  16. Fourth Annual International Pulmonary Alveolar Proteinosis Research Conference
    Bruce Trapnell; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. GM-CSF & Alveolar Macrophage Antiviral Lung Defense
    Bruce Trapnell; Fiscal Year: 2004
    ..abstract_text> ..
  18. AAT Deficiency & Liver Diseases Caused by Proteins
    Bruce Trapnell; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  19. Regulation of Alveolar Macrophage Phagocytosis
    Bruce Trapnell; Fiscal Year: 2006
    ..1, and Hck/SFKs in AMs. Results of this research are expected to help establish the feasibility of the therapeutic use of GM-CSF in the treatment of lung infections by a wide variety of microbial pathogens. ..
  20. H2O2-PRODUCING LACTOBACILLI AND POSTMENOPAUSAL UTI
    Kalpana Gupta; Fiscal Year: 2005
    ....
  21. MECHANISTIC STUDIES ON PHOSPHORUS REDOX ENZYMES
    WILLEM VAN DER DONK; Fiscal Year: 2006
    ..The studies on HtxA focus on potential use of alternative substrates as well as developing a fundamental understanding of the mode of catalysis. ..
  22. Cranberry and Prevention of UTI A Comprehensive Approach
    Kalpana Gupta; Fiscal Year: 2007
    ....
  23. ENZYMOLOGY OF ANTIBIOTIC RESISTANCE
    Richard Armstrong; Fiscal Year: 2007
    ..b>Fosfomycin is a potent, broad-spectrum antibiotic effective against both Gram-positive and Gram-negative microorganisms...
  24. 2007 Vitamin B12 and Corphins Gordon Conference
    WILLEM VAN DER DONK; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..