clodronic acid

Summary

Summary: A diphosphonate which affects calcium metabolism. It inhibits bone resorption and soft tissue calcification.

Top Publications

  1. pmc Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach
    S M Zeisberger
    Molecular Cell Biology, Laboratory of Biomolecular Research, Paul Scherrer Institute, CH 5232 Villigen PSI, Switzerland
    Br J Cancer 95:272-81. 2006
  2. ncbi Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
    S Boissier
    , , Lyon, France
    Cancer Res 60:2949-54. 2000
  3. ncbi Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial
    Alexander H G Paterson
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Lancet Oncol 13:734-42. 2012
  4. ncbi Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects
    Wei Zhang
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, P R China
    Clin Cancer Res 16:3420-30. 2010
  5. ncbi "In vivo" depletion of macrophages by liposome-mediated "suicide"
    Nico Van Rooijen
    Department of Cell and Immunology, Faculty of Medicine, Vrije Universiteit Medical Center, Van de Boechhorststraat 7, 1081 BT Amsterdam, The Netherlands
    Methods Enzymol 373:3-16. 2003
  6. pmc Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death
    Clotilde Lauro
    Istituto Pasteur, Fondazione Cenci Bolognetti, Rome, Italy
    Neuropsychopharmacology 35:1550-9. 2010
  7. ncbi Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2
    Darko S Markovic
    Cellular Neuroscience Group, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    J Neuropathol Exp Neurol 64:754-62. 2005
  8. pmc Bisphosphonates induce apoptosis in human breast cancer cell lines
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 82:1459-68. 2000
  9. ncbi Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    S P Luckman
    Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, United Kingdom
    J Bone Miner Res 13:581-9. 1998
  10. ncbi Impaired splenic erythropoiesis in phlebotomized mice injected with CL2MDP-liposome: an experimental model for studying the role of stromal macrophages in erythropoiesis
    Y Sadahira
    Department of Pathology, Kawasaki Medical School, Kurashiki, Japan
    J Leukoc Biol 68:464-70. 2000

Research Grants

  1. Role of Vitamin D in Dendritic Cell Immune Functions
    Matthew Griffin; Fiscal Year: 2004
  2. Organophosphates Modify Eosinophil and Nerve Interaction
    Becky Proskocil; Fiscal Year: 2008
  3. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
  4. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
  5. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
  6. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
  7. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
  8. Pertussis Toxin Trafficking and Processing in Cells
    NICHOLAS CARBONETTI; Fiscal Year: 2005
  9. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
  10. Role of Pertussis Toxin in Bordetella pertussis infection
    Nicholas H Carbonetti; Fiscal Year: 2010

Detail Information

Publications193 found, 100 shown here

  1. pmc Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach
    S M Zeisberger
    Molecular Cell Biology, Laboratory of Biomolecular Research, Paul Scherrer Institute, CH 5232 Villigen PSI, Switzerland
    Br J Cancer 95:272-81. 2006
    ....
  2. ncbi Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
    S Boissier
    , , Lyon, France
    Cancer Res 60:2949-54. 2000
    ..These results suggest, therefore, that BPs may be useful agents for the prophylactic treatment of patients with cancers that are known to preferentially metastasize to bone...
  3. ncbi Oral clodronate for adjuvant treatment of operable breast cancer (National Surgical Adjuvant Breast and Bowel Project protocol B-34): a multicentre, placebo-controlled, randomised trial
    Alexander H G Paterson
    National Surgical Adjuvant Breast and Bowel Project, Pittsburgh, PA, USA
    Lancet Oncol 13:734-42. 2012
    ..The National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-34 aims to ascertain whether oral clodronate can improve outcomes in women with primary breast cancer...
  4. ncbi Depletion of tumor-associated macrophages enhances the effect of sorafenib in metastatic liver cancer models by antimetastatic and antiangiogenic effects
    Wei Zhang
    Liver Cancer Institute and Zhongshan Hospital, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, the Chinese Ministry of Education, Shanghai, P R China
    Clin Cancer Res 16:3420-30. 2010
    ..To investigate the role of macrophages in tumor progression under sorafenib treatment and to explore whether combination of drugs that deplete macrophages improved the antitumor effect of sorafenib...
  5. ncbi "In vivo" depletion of macrophages by liposome-mediated "suicide"
    Nico Van Rooijen
    Department of Cell and Immunology, Faculty of Medicine, Vrije Universiteit Medical Center, Van de Boechhorststraat 7, 1081 BT Amsterdam, The Netherlands
    Methods Enzymol 373:3-16. 2003
  6. pmc Adenosine A1 receptors and microglial cells mediate CX3CL1-induced protection of hippocampal neurons against Glu-induced death
    Clotilde Lauro
    Istituto Pasteur, Fondazione Cenci Bolognetti, Rome, Italy
    Neuropsychopharmacology 35:1550-9. 2010
    ....
  7. ncbi Microglia stimulate the invasiveness of glioma cells by increasing the activity of metalloprotease-2
    Darko S Markovic
    Cellular Neuroscience Group, Max Delbrück Center for Molecular Medicine MDC, Berlin, Germany
    J Neuropathol Exp Neurol 64:754-62. 2005
    ..Our data indicate that glioma cells stimulate microglial cells to increase breakdown of extracellular matrix and thereby promote tumor invasiveness...
  8. pmc Bisphosphonates induce apoptosis in human breast cancer cell lines
    S G Senaratne
    Department of Oncology, Gastroenterology, Endocrinology and Metabolism, St George s Hospital Medical School, London, UK
    Br J Cancer 82:1459-68. 2000
    ....
  9. ncbi Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    S P Luckman
    Department of Human Metabolism and Clinical Biochemistry, University of Sheffield, United Kingdom
    J Bone Miner Res 13:581-9. 1998
    ..Furthermore, the data support the view that clodronate acts by a different mechanism...
  10. ncbi Impaired splenic erythropoiesis in phlebotomized mice injected with CL2MDP-liposome: an experimental model for studying the role of stromal macrophages in erythropoiesis
    Y Sadahira
    Department of Pathology, Kawasaki Medical School, Kurashiki, Japan
    J Leukoc Biol 68:464-70. 2000
    ....
  11. ncbi Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis
    Florence Daubiné
    INSERM Research Unit U 664, Universite Claude Bernard Lyon 1, Lyon, France
    J Natl Cancer Inst 99:322-30. 2007
    ..We compared the antitumor effects of clinical dosing regimens of the bisphosphonates zoledronic acid and clodronate in a mouse model of bone metastasis...
  12. ncbi Blockade of tumor necrosis factor alpha signaling in tumor-associated macrophages as a radiosensitizing strategy
    Yuru Meng
    Department of Radiation and Cellular Oncology and Department of Medicine, Section of Hematology Oncology, The University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 70:1534-43. 2010
    ..Our findings offer a mechanistic basis to target macrophage populations generally or TNFalpha-induced macrophage VEGF specifically as tractable strategies to improve the efficacy of radiotherapy...
  13. ncbi Changes in murine bone marrow macrophages and erythroid burst-forming cells following the intravenous injection of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP)
    A L Giuliani
    Dipartimento di Medicina Sperimentale e Diagnostica, Sezione di Patologia Generale, , Ferrara, Italy
    Eur J Haematol 66:221-9. 2001
    ..The results suggest that mice treated with liposome-encapsulated Cl2MDP are a model for studying the role of macrophages in erythropoiesis...
  14. pmc Role of lung-marginated monocytes in an in vivo mouse model of ventilator-induced lung injury
    Michael R Wilson
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea, United Kingdom
    Am J Respir Crit Care Med 179:914-22. 2009
    ..Inflammatory subset Gr-1(high) monocytes are recruited to sites of inflammation and have been implicated in acute lung injury induced by systemic endotoxin...
  15. ncbi Intra-articular clodronate for the treatment of knee osteoarthritis: dose ranging study vs hyaluronic acid
    Maurizio Rossini
    Rheumatology Unit, University of Verona, Verona, Italy
    Rheumatology (Oxford) 48:773-8. 2009
    ..In this Phase 2 randomized, partially blind clinical trial, we tested the efficacy of IA clodronate vs HA in patients with primary KOA...
  16. ncbi Ten-year follow-up of a randomized controlled trial of adjuvant clodronate treatment in node-positive breast cancer patients
    Tiina Saarto
    Department of Oncology, Helsinki University Central Hospital, Finland
    Acta Oncol 43:650-6. 2004
    ..A negative effect of clodronate on DFS by increasing the development of visceral metastases was still seen at 10 years, but this did not significantly compromise overall survival...
  17. ncbi Aging of red blood cells and impaired erythropoiesis following prolonged administration of dichloromethylene diphosphonate containing liposomes in rats
    Anna Lisa Giuliani
    Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Ferrara, Italy
    Eur J Haematol 75:406-16. 2005
    ..To investigate whether macrophage-depleted rats may serve as a model for studying red blood cell (RBC) aging...
  18. ncbi Clodronate liposomes: perspectives in research and therapeutics
    Nico Van Rooijen
    Department of Molecular Cell Biology, Research Institute of Immunology and Inflammation, Faculty of Medicine, Vrije Universiteit Van der Boechorststraat, Amsterdam, The Netherlands
    J Liposome Res 12:81-94. 2002
    ....
  19. ncbi Liposomes for specific depletion of macrophages from organs and tissues
    Nico Van Rooijen
    Department of Molecular Cell Biology and Immunology, VU University Medical Center, Amsterdam, The Netherlands
    Methods Mol Biol 605:189-203. 2010
    ..In several cases, organ specific depletion can be obtained by choosing the right administration route for the clodronate liposomes...
  20. ncbi Macrophage depletion by clodronate-containing liposomes reduces neointimal formation after balloon injury in rats and rabbits
    Haim D Danenberg
    Department of Cardiology, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Circulation 106:599-605. 2002
    ..Excessive inflammation enhances neointimal formation and restenosis. We examined whether transient systemic inactivation of macrophages at the time of vascular intervention could attenuate the degree of expected restenosis...
  21. ncbi Influence of clodronate on breast cancer cells in vitro
    M Busch
    Klinik und Poliklinik für Strahlentherapie und Radioonkologie, Ludwig Maximilians University Munchen, Klinikum Grosshadern, Marchioninistr 15, D 81377 Munchen, Germany
    Eur J Med Res 3:427-31. 1998
    ..But the influence of clodronate alone on tumour cells is not quite clear. Radiotherapy and administration of clodronate increasingly are used in combination. The influence of clodronate on radiosensitivity of tumour cells is not known...
  22. ncbi Kupffer cell activation is a causal factor for hepatic insulin resistance
    Nicolas Lanthier
    Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Ave Mounier 53, B 1200 Brussels, Belgium
    Am J Physiol Gastrointest Liver Physiol 298:G107-16. 2010
    ....
  23. ncbi Ten-year fracture probability identifies women who will benefit from clodronate therapy--additional results from a double-blind, placebo-controlled randomised study
    E V McCloskey
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK
    Osteoporos Int 20:811-7. 2009
    ..This study demonstrates that the estimation of an individual's 10-year probability of fracture by the FRAX algorithm identifies patients at high risk of fracture who will respond to bisphosphonate therapy...
  24. ncbi The molecular mechanism of action of the antiresorptive and antiinflammatory drug clodronate: evidence for the formation in vivo of a metabolite that inhibits bone resorption and causes osteoclast and macrophage apoptosis
    J C Frith
    Department of Medicine and Therapeutics, University of Aberdeen Medical School, Foresterhill, UK
    Arthritis Rheum 44:2201-10. 2001
    ..CONCLUSION: These results provide the first direct evidence that the antiinflammatory and antiresorptive effects of clodronate on macrophages and osteoclasts in vivo occur via the intracellular formation of AppCCl2p...
  25. ncbi Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite
    Petri P Lehenkari
    Department of Surgery, University of Oulu, Oulu, Finland
    Mol Pharmacol 61:1255-62. 2002
    ..Hence, inhibition of the ADP/ATP translocase by the metabolite AppCCl(2)p is a likely route by which clodronate causes osteoclast apoptosis and inhibits bone resorption...
  26. ncbi Inflammatory cytokine release of astrocytes in vitro is reduced by all-trans retinoic acid
    Sabien van Neerven
    Institut fur Biologie II, RWTH Aachen University, Aachen, Germany
    J Neuroimmunol 229:169-79. 2010
    ..01). The data are consistent with the hypothesis that all-trans RA takes part in endogenous anti-inflammatory feedback loops in the CNS...
  27. ncbi The bisphosphonate clodronate depletes microglial cells in excitotoxically injured organotypic hippocampal slice cultures
    A Kohl
    University Hospital for Orthopaedic Surgery Friedrichsheim, Marienburgstrasse 2, D 60528 Frankfurt am Main, Federal Republic of Germany
    Exp Neurol 181:1-11. 2003
    ..Our results demonstrate that clodronate is a useful tool in the investigation of neuron-glia interactions because it induces an efficient depletion of microglial cells that are activated after excitotoxic CNS injury...
  28. ncbi Depletion of macrophages in mice results in higher dengue virus titers and highlights the role of macrophages for virus control
    Katja Fink
    Novartis Institute for Tropical Diseases, Biopolis, Singapore
    Eur J Immunol 39:2809-21. 2009
    ..Instead, we demonstrate the importance of monocytes/macrophages for the control of dengue virus...
  29. pmc Effects of zoledronic acid versus clodronic acid on skeletal morbidity in patients with newly diagnosed multiple myeloma (MRC Myeloma IX): secondary outcomes from a randomised controlled trial
    Gareth J Morgan
    Section of Haemato oncology, Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, UK
    Lancet Oncol 12:743-52. 2011
    ..The MRC Myeloma IX study was designed to compare the effects of zoledronic acid versus clodronic acid in newly diagnosed patients with multiple myeloma...
  30. pmc First-line treatment with zoledronic acid as compared with clodronic acid in multiple myeloma (MRC Myeloma IX): a randomised controlled trial
    Gareth J Morgan
    Institute of Cancer Research, Royal Marsden NHS Foundation Trust, London, UK
    Lancet 376:1989-99. 2010
    ..We aimed to establish whether bisphosphonates can affect clinical outcomes in patients with multiple myeloma...
  31. pmc Adjuvant oral clodronate improves the overall survival of primary breast cancer patients with micrometastases to the bone marrow: a long-term follow-up
    I J Diel
    Department of Gynecology and Obstetrics, University of Heidelberg, Heidelberg, Germany
    Ann Oncol 19:2007-11. 2008
    ..Adding oral clodronate to postoperative adjuvant breast cancer therapy significantly improves disease-free survival (DFS) and overall survival (OS). Long-term follow-up data from the prospective, randomized, controlled study are reported...
  32. ncbi Clodronate inhibits the secretion of proinflammatory cytokines and NO by isolated microglial cells and reduces the number of proliferating glial cells in excitotoxically injured organotypic hippocampal slice cultures
    Faramarz Dehghani
    Institute of Anatomy II, Johann Wolfgang Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Exp Neurol 189:241-51. 2004
    ..Furthermore, clodronate inhibits microglial secretion of proinflammatory cytokines and NO. Clodronate could therefore prove to be a useful tool in the investigation of interactions between damaged neurons and microglial cells...
  33. ncbi Bisphosphonates act directly on the osteoclast to induce caspase cleavage of mst1 kinase during apoptosis. A link between inhibition of the mevalonate pathway and regulation of an apoptosis-promoting kinase
    A A Reszka
    Department of Bone Biology, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    J Biol Chem 274:34967-73. 1999
    ..For alendronate and risedronate, these events seem to be downstream of inhibition of geranylgeranylation...
  34. ncbi Effects of clodronate and alendronate on local and systemic changes in bone metabolism in rats with adjuvant arthritis
    Fumiaki Itoh
    Department of Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Tokyo, Japan
    Inflammation 28:15-21. 2004
    ..Clodronate would be useful in the treatment of inflammation-induced bone deformation and osteopenia...
  35. ncbi High-dose clodronate therapy prevents joint destruction in chronic antigen-induced arthritis of the rat but inhibits bone formation at the axial skeleton
    P Oelzner
    Department of Internal Medicine IV, Friedrich Schiller University of Jena, Germany
    Inflamm Res 49:424-33. 2000
    ..To investigate the effects of clodronate on clinical disease activity, inflammatory alterations and cartilage destruction, periarticular and axial bone volume and bone turnover in chronic antigen-induced arthritis (AIA; day 28)...
  36. ncbi Clodronate : a review of its use in the prevention of bone metastases and the management of skeletal complications associated with bone metastases in patients with breast cancer
    Toni M Dando
    Adis International Limited, Auckland, New Zealand
    Drugs Aging 21:949-62. 2004
    ..In the meantime, clodronate is a well established bisphosphonate which has shown beneficial effects in the prevention of bone metastases and on survival in patients with primary breast cancer...
  37. ncbi Oral sodium clodronate for nonmetastatic prostate cancer--results of a randomized double-blind placebo-controlled trial: Medical Research Council PR04 (ISRCTN61384873)
    Malcolm D Mason
    Velindre Hospital, Department of Oncology and Palliative Medicine, School of Medicine, Cardiff University, Cardiff, UK
    J Natl Cancer Inst 99:765-76. 2007
    ..Adjuvant bisphosphonate treatment improves outcomes of patients with bone metastasis-negative breast cancer, but the effects of bisphosphonates on bone metastases in prostate cancer are not known...
  38. pmc Reduction in bone relapse and improved survival with oral clodronate for adjuvant treatment of operable breast cancer [ISRCTN83688026]
    Trevor Powles
    Parkside Oncology, London, UK
    Breast Cancer Res 8:R13. 2006
    ....
  39. ncbi Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma
    E V McCloskey
    WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Medical School, Sheffield, UK
    Br J Haematol 113:1035-43. 2001
    ..These observations, however, require confirmation in prospective clinical trials...
  40. ncbi Oral clodronate in breast cancer patients with bone metastases: a randomized study
    B Kristensen
    Department of Oncology, Finsen Center, Copenhagen University Hospital, Denmark
    J Intern Med 246:67-74. 1999
    ..To investigate the effect of the bisphosphonate clodronate on the occurrence of skeletal events (hypercalcaemia, fractures and radiotherapy) in breast cancer patients with bone metastases...
  41. ncbi Intermittent intramuscular clodronate therapy: a valuable option for older osteoporotic women
    Ligia J Dominguez
    Geriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, viale F Scaduto 6 c, 90144 Palermo, Italy
    Age Ageing 34:633-6. 2005
  42. ncbi [Use of clodronic acid in mineral metabolism conditions: state of the art in 2000]
    M L Brandi
    Dipartimento di Medicina Interna, , Firenze, Italy
    Minerva Med 92:251-68. 2001
    b>Clodronic acid is a non-aminate bisphosphonate capable of inhibiting bone resorption...
  43. ncbi Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft
    Silvina Gazzaniga
    Department Biological Chemistry, Faculty of Sciences, University of Buenos Aires, Buenos Aires, Argentina
    J Invest Dermatol 127:2031-41. 2007
    ..We suggest that bindarit or Clod-Lip abrogates protumoral-associated macrophages in human melanoma xenografts and could be considered as complementary approaches to antiangiogenic therapy...
  44. pmc Loss of Kupffer cells in diet-induced obesity is associated with increased hepatic steatosis, STAT3 signaling, and further decreases in insulin signaling
    Alicia H Clementi
    Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Biochim Biophys Acta 1792:1062-72. 2009
    ..One or more additional factors appear to be required, however, for the Kupffer cell-dependent protective effect on insulin receptor signaling in DIO mice...
  45. ncbi Clodronate reduces vertebral fracture risk in women with postmenopausal or secondary osteoporosis: results of a double-blind, placebo-controlled 3-year study
    Eugene McCloskey
    Division of Genomic Medicine, The World Health Organization Collaborating Centre for Metabolic Bone Diseases, University of Sheffield Medical School, Sheffield, United Kingdom
    J Bone Miner Res 19:728-36. 2004
    ..The incidence of vertebral fractures was significantly reduced by 46%. The effect was not modified by the underlying cause of osteoporosis or other baseline factors including bone mineral density, QUS, weight, and smoking...
  46. ncbi Efficacy of disodium-clodronate in the management of joint pain in rheumatoid arthritis. Six months open study
    G Rovetta
    Rheumatology Centre, Istituto Bruzzone, USL 3, University of Genoa, Rheumatology Medical School DISEM, University of Genoa, Genoa, Italy
    Minerva Med 94:353-7. 2003
    ..The aim of the study was to evaluate the effect on the articular pain of 100 mg of disodium-clodronate administered for 6 days a week by intramuscular injection in rheumatoid arthritis (RA) patients...
  47. ncbi Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study
    Eugene V McCloskey
    Northern General Hospital, Sheffield, UK
    J Bone Miner Res 22:135-41. 2007
    ..The effect occurred in the absence of systematic calcium and vitamin D supplementation and was observed across a wide range of BMDs...
  48. ncbi A double-blind, placebo-controlled, randomized trial of oral sodium clodronate for metastatic prostate cancer (MRC PR05 Trial)
    David P Dearnaley
    Institute of Cancer Research and Royal Marsden Hospital, Sutton, UK
    J Natl Cancer Inst 95:1300-11. 2003
    ....
  49. pmc Adjuvant therapy with oral sodium clodronate in locally advanced and metastatic prostate cancer: long-term overall survival results from the MRC PR04 and PR05 randomised controlled trials
    David P Dearnaley
    Royal Marsden Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK
    Lancet Oncol 10:872-6. 2009
    ..We report the final analyses of long-term survival data with additional follow-up in both trials...
  50. ncbi Bisphosphonates in the prevention of bone metastases: current evidence
    I J Diel
    Department of Obstetrics and Gynaecology, University of Heidelberg, Germany
    Semin Oncol 28:75-80. 2001
    ..This article evaluates and presents the results of these studies, and reviews current evidence surrounding the prophylactic use of bisphosphonates for skeletal progression of breast cancer...
  51. ncbi Intravenous clodronate in the treatment of reflex sympathetic dystrophy syndrome. A randomized, double blind, placebo controlled study
    M Varenna
    Department of Rheumatology, Istituto Ortopedico Gaetano Pini, Milano, Italy
    J Rheumatol 27:1477-83. 2000
    ..To evaluate the efficacy of intravenous (i.v.) clodronate in patients with reflex sympathetic dystrophy syndrome (RSDS) and to assess the urinary excretion of type I collagen crosslinked N-telopeptide (NTx) before and after the treatment...
  52. ncbi Clodronate inhibits PGE(2) production in compressed periodontal ligament cells
    L Liu
    Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai 980 8575, Japan
    J Dent Res 85:757-60. 2006
    ..These results suggest that the inhibitory effects of clodronate on tooth movement and osteoclasts may be due, at least in part, to the inhibition of COX-2-dependent PGE(2) production and RANKL expression in PDL cells...
  53. ncbi Analgesic effect of bisphosphonates in mice
    A Bonabello
    Research Department, SPA Societa Prodotti Antibiotici S p A, Via Bella 8, Milan, Italy
    Pain 91:269-75. 2001
    ....
  54. ncbi Clodronate: mechanisms of action on bone remodelling and clinical use in osteometabolic disorders
    Valentina Ghinoi
    Department of Internal Medicine, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
    Expert Opin Pharmacother 3:1643-56. 2002
    ..However, studies that demonstrate an effect on the rate of fractures are needed before any recommendation can be made...
  55. ncbi "Twice-a-month" clodronate 200 mg IM: a new dosing regimen and improved therapy adherence in the treatment of postmenopausal osteoporosis
    M Muratore
    U O Rheumatology, Hospital Galateo, 73016 San Cesario di Lecce LE, Italy
    Adv Ther 27:314-20. 2010
    ..Secondary aims were the assessments of bone resorption markers, safety, tolerability, pain, and patient compliance...
  56. ncbi Antiresorption therapy and reduction in fracture susceptibility in the osteoporotic elderly patient: open study
    E Muscoso
    Department of Senescent, Urological and Neurological Sciences, University of Catania, Italy
    Eur Rev Med Pharmacol Sci 8:97-102. 2004
    ....
  57. ncbi Adjuvant bisphosphonates in breast cancer: are we witnessing the emergence of a new therapeutic strategy?
    R E Coleman
    Academic Unit of Clinical Oncology, Cancer Research Centre, Weston Park Hospital NHS Trust, Sheffield, UK
    Eur J Cancer 45:1909-15. 2009
    ..The results of ongoing large metastasis prevention trials are however, required before routine use of adjuvant bisphosphonates can be recommended...
  58. ncbi Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
    Koji Hiraoka
    Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
    Cancer Sci 99:1595-602. 2008
    ....
  59. ncbi Effects of Kupffer cell-depletion on Concanavalin A-induced hepatitis
    Masayo Hatano
    Division of Molecular Medicine, Department of Biomolecular Science, Faculty of Science, Toho University, Funabashi, Chiba 274 8510, Japan
    Cell Immunol 251:25-30. 2008
    ..Taken together, these results suggest that Kupffer cells are involved in the production of MIP-2, KC, IL-4, and TNF-alpha in Con A-induced hepatitis, thereby contributing to the liver injury either directly or indirectly...
  60. ncbi Crucial role of marginal zone macrophages and marginal zone metallophils in the clearance of lymphocytic choriomeningitis virus infection
    P Seiler
    Department of Pathology, University Hospital Zurich, Switzerland
    Eur J Immunol 27:2626-33. 1997
    ..These findings suggest that MZM and MM play a crucial role in the early control of a LCMV infection by preventing immediate virus spread to peripheral organs, but are not essential for the induction of the LCMV-specific CTL response...
  61. ncbi The cellular uptake and metabolism of clodronate in RAW 264 macrophages
    H Mönkkönen
    Department of Pharmaceutics, University of Kuopio, Finland
    Pharm Res 18:1550-5. 2001
    ....
  62. pmc Antitumor activity of liposomal prednisolone phosphate depends on the presence of functional tumor-associated macrophages in tumor tissue
    Manuela Banciu
    Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences UIPS, Utrecht University, Utrecht, The Netherlands
    Neoplasia 10:108-17. 2008
    ..One of the major inhibitory actions of LCL-PLP on tumor growth is the reduction of the TAM-mediated production of pro-angiogenic factors, whereas production of anti-angiogenic factors by these cells is hardly affected...
  63. ncbi The bisphosphonate pamidronate is a potent inhibitor of human osteosarcoma cell growth in vitro
    J Sonnemann
    Labor für Experimentelle Orthopädie Zellbiologie, Klinik und Poliklinik für Allgemeine Orthopädie, Universitatsklinikum Munster, Domagkstrasse 3, 48149 Munster, Germany
    Anticancer Drugs 12:459-65. 2001
    ..Importantly, cell growth of fibroblasts was only very weakly affected by treatment with pamidronate. These results suggest that pamidronate may be a useful agent for the treatment of patients with osteosarcoma...
  64. ncbi Bisphosphonates inhibit angiogenesis in vitro and testosterone-stimulated vascular regrowth in the ventral prostate in castrated rats
    Pierrick Fournier
    Institut National de la Sante et de la Recherche Medicale, Research Unit 403, Faculty of Medicine Laennec, Lyon 69372, France
    Cancer Res 62:6538-44. 2002
    ..In addition, our results extend the potential clinical use of BPs to patients with early prostate cancer...
  65. ncbi Extended safety profile of oral clodronate after long-term use in primary breast cancer patients
    Sari Atula
    Schering Oy, Helsinki 00101, Finland
    Drug Saf 26:661-71. 2003
    ..Here we present expanded safety and tolerability results for clodronate treatment from this trial (cut-off date extended from June 1997 to June 2000)...
  66. ncbi Enhanced engraftment of human cells in RAG2/gammac double-knockout mice after treatment with CL2MDP liposomes
    Henk Rozemuller
    Department of Haematology, Jordan Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Exp Hematol 32:1118-25. 2004
    ..We studied the applicability of the immunodeficient RAG2(-/-)gammac(-/-) double-knockout mouse for this purpose...
  67. ncbi Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis
    H Baatz
    Department of Ophthalmology, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Exp Eye Res 73:101-9. 2001
    ..CL(2)MDP-lip prevented the inflammatory reaction of EMIU and inhibited the increase of leukocyte-endothelium interaction in iris vessels. Our findings emphasize the pivotal role macrophages play in the initiation of autoimmune disease...
  68. ncbi A method for the selective depletion of perivascular and meningeal macrophages in the central nervous system
    M M Polfliet
    Department of Cell Biology and Immunology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, Netherlands
    J Neuroimmunol 116:188-95. 2001
    ..This selective depletion method of the PVM and MM will enable us to get direct insight in their functions during normal and pathologic conditions of the CNS...
  69. ncbi Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
    Trevor Powles
    Royal Marsden National Health Service Trust, Royal Marsden Hospital, Downs Road, Sutton, Surrey SM2 5PT, UK
    J Clin Oncol 20:3219-24. 2002
    ..Given to patients with primary breast cancer, clodronate might reduce the subsequent incidence of bone metastases...
  70. ncbi Adjuvant clodronate treatment does not reduce the frequency of skeletal metastases in node-positive breast cancer patients: 5-year results of a randomized controlled trial
    T Saarto
    Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    J Clin Oncol 19:10-7. 2001
    ..However, clodronate seems to have a negative effect on DFS by increasing the development of nonskeletal metastases...
  71. ncbi Liposomes for targeting of antigens and drugs: immunoadjuvant activity and liposome-mediated depletion of macrophages
    Nico Van Rooijen
    Department of Molecular Cell Biology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    J Drug Target 16:529-34. 2008
    ..In several cases, organ-specific depletion can be obtained by choosing the right administration route for the clodronate liposomes...
  72. ncbi Nitrogen-containing bisphosphonates inhibit isopentenyl pyrophosphate isomerase/farnesyl pyrophosphate synthase activity with relative potencies corresponding to their antiresorptive potencies in vitro and in vivo
    E van Beek
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, The Netherlands
    Biochem Biophys Res Commun 255:491-4. 1999
    ..Our study reveals for the first time the intracellular target of N-containing bisphosphonates and supports the view that all bisphosphonates do not share the same molecular mechanism of action...
  73. ncbi Apoptotic cell death in activated monocytes following incorporation of clodronate-liposomes
    C B Schmidt Weber
    Department of Medicine III, Institute of Anatomy, University of Erlangen Nuremberg, Germany
    J Leukoc Biol 60:230-44. 1996
    ..Selective elimination of activated Mphis by apoptosis may explain both therapeutic efficacy and safety of clodronate-liposomes in experimental models of autoimmunity...
  74. ncbi Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    ..We conclude that the full extent of IRI requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A(2A)Rs...
  75. pmc Long-term release of clodronate from biodegradable microspheres
    P Perugini
    Department of Pharmaceutical Chemistry, University of Pavia, Pavia, Italy
    AAPS PharmSciTech 2:E10. 2001
    ..Clodronate was successfully entrapped in PLGA and PDLLA microspheres, and drug release could be modulated from 48 hours up to 3 months by suitable selection of polymer, composition, additives, and manufacturing conditions...
  76. ncbi Mechanism of action of bisphosphonates
    Alfred A Reszka
    Department of Molecular Endocrinology and Bone Biology, Merck Research Laboratories, West Point, PA 19846, USA
    Curr Osteoporos Rep 1:45-52. 2003
    ..Although nitrogen-containing bisphosphonates can induce osteoclast apoptosis, this is not necessary for their inhibition of bone resorption...
  77. ncbi Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound
    B Frediani
    Institute of Rheumatology, University of Siena, Siena, Italy
    Bone 33:575-81. 2003
    ..63 (0.35-0.98, 95% CI) and 0.25 (0.15-0.91, 95% CI), respectively. We concluded that pulsatory administration of im clodronate once weekly is a safe therapy for preventing corticosteroid induced osteoporosis in patients with arthritis...
  78. ncbi Current and future status of adjuvant therapy for breast cancer
    Robert E Coleman
    Cancer Research Centre, Yorkshire Cancer Research Academic Unit of Clinical Oncology, Weston Park Hospital, Sheffield, United Kingdom
    Cancer 97:880-6. 2003
    ..It may be possible to replace the current oral regimens for prevention of bone loss with a single annual infusion of the highly potent bisphosphonate zoledronic acid...
  79. pmc Effective treatment of malignant hypercalcaemia with a single intravenous infusion of clodronate
    E V McCloskey
    Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, UK
    Br J Cancer 67:560-3. 1993
    ..The single infusion has a more rapid onset of effect, is more convenient than multiple infusions, and has no adverse effect on renal function...
  80. ncbi Bisphosphonates and tumor burden
    Gregory R Mundy
    J Clin Oncol 20:3191-2. 2002
  81. ncbi Bisphosphonate prodrugs: synthesis and in vitro evaluation of novel acyloxyalkyl esters of clodronic acid
    R Niemi
    Departments of Pharmaceutical Chemistry and Chemistry, University of Kuopio, P O Box 1627, FIN 70211 Kuopio, Finland, and Finncovery Ltd Kuopio, Finland
    J Med Chem 42:5053-8. 1999
    Novel tetra-, tri-, and P,P'-dipivaloyloxymethyl esters of clodronic acid were synthesized, and their properties as possible prodrugs of clodronate were evaluated in vitro...
  82. ncbi [Pharmacological treatment of osteitis deformans (Paget's bone disease)]
    Kim T Brixen
    Odense Universitetshospital, Endokrinologisk Afdeling M, og Arhus Universitetshospital, Arhus Sygehus, Medicinsk Endokrinologisk Afdeling C
    Ugeskr Laeger 167:1009-12. 2005
  83. ncbi A crucial role for macrophages in the pathology of K/B x N serum-induced arthritis
    Samuel Solomon
    Immunology, Department of Biology, Faculty of Sciences, University of Konstanz, Konstanz, Germany
    Eur J Immunol 35:3064-73. 2005
    ....
  84. pmc Histological analysis of CD11c-DTR/GFP mice after in vivo depletion of dendritic cells
    H C Probst
    Institute of Experimental Immunology, University Hospital Zurich, Zurich, Switzerland
    Clin Exp Immunol 141:398-404. 2005
    ..This finding limits the use of CD11c-DTR/GFP mice for the analysis of the role of DC to models and read outs that are proven to be independent of marginal zone and sinusoidal M(Phi)...
  85. ncbi A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- gammac-/- double-mutant mice
    Rozemarijn S van Rijn
    Jordan Laboratory for Hemato Oncology, Department of Hematology, University Medical Center Utrecht, The Netherlands
    Blood 102:2522-31. 2003
    ..In conclusion, we present a new model for X-GVHD by intravenous transfer of huPBMCs in RAG2-/- gammac-/- mice. Murine and human macrophages do not seem to be necessary for acute X-GVHD in this model...
  86. ncbi Inhibition of inflammatory and bone-resorption-inhibitory effects of alendronate by etidronate
    H Funayama
    Department of Molecular Regulation, Graduate School of Dentistry, Tohoku University, Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    Calcif Tissue Int 76:448-57. 2005
    ..We discuss the mechanisms underlying the antagonism between aminoBPs and non-aminoBPs...
  87. ncbi [Expanding the possibilities of using biphosphonates for prophylaxis and treatment of osteal complications in malignant metastasis]
    Iu A Svishchenko
    Eksp Klin Farmakol 67:66-71. 2004
    ..It is emphasized that clodronate, which is most thoroughly investigated drug of this group, can be more frequently used in clinics for the treatment and prophylaxis of osteal complications in cases of breast cancer...
  88. ncbi The reactive D-glucopyranose moiety of streptozotocin is responsible for activation of macrophages and subsequent stimulation of CD8+ T cells
    Stefan Nierkens
    Institute for Risk Assessment Sciences, Immunotoxicology, Utrecht University, P O Box 80176, NL 3508 TD Utrecht, The Netherlands
    Chem Res Toxicol 18:872-9. 2005
    ..Present results support the idea that MPhi activation is indispensable for the STZ-induced tissue destructive type 1 responses and that various STZ-induced type 1 immune responses are differently regulated...
  89. ncbi Should oral bisphosphonates be standard of care in women with early breast cancer?
    Mark Clemons
    Division of Medical Oncology, Toronto Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Breast Cancer Res Treat 90:315-8. 2005
    ..This article outlines the results of these studies and discusses the potential role for other bisphosphonates, such as ibandronate and zoledronic acid, in the adjuvant treatment of breast cancer...
  90. ncbi The role of bisphosphonates in the management of advanced cancer with a focus on non-small-cell lung cancer. Part 1: Mechanisms of action, role of biomarkers and preclinical applications
    Nabil Saba
    Winship Cancer Institute, Emory University, Atlanta, GA, USA
    Oncology 68:10-7. 2005
    ..We include a review of mechanistic studies and preclinical data. Additionally, the utility of evolving concepts such as bone markers and imaging of bone metastases are discussed...
  91. ncbi Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo
    Dan Qing Lou
    Département de génétique, Developpement et Pathologie Moleculaire, Institut National de la Sante et de la Recherche Medicale, Centre National de la Recherche Scientifique, et Université René Descartes, Faculté de Médecine Cochin Port Royal, Paris, France
    Hepatology 41:1056-64. 2005
    ....
  92. ncbi Rapid recovery of platelet count following administration of liposome-encapsulated clodronate in a mouse model of immune thrombocytopenia
    Fernanda Alves-Rosa
    Division Inmunologia, Instituto de Investigaciones Hematologicas, Academia Nacional de Medicina, Buenos Aires, Argentina
    Br J Haematol 116:357-66. 2002
    ..All these data demonstrate that LIP-CLOD deserves consideration as a potential therapeutic approach in thrombocytopenic states in which the rapid increase of platelet count is the primary goal...
  93. ncbi Macrophages and skeletal muscle regeneration: a clodronate-containing liposome depletion study
    Mukesh Summan
    Health Effects Laboratory Div, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1488-95. 2006
    ..In conclusion, a significant reduction of the initial monocyte/macrophage influx into the injured muscle is associated with not improved, but moderately impaired, repair processes after skeletal muscle injury...
  94. ncbi The role of perivascular and meningeal macrophages in experimental allergic encephalomyelitis
    Machteld M J Polfliet
    Department of Molecular Cell Biology, Faculty of Medicine, Vrije Universiteit, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Neuroimmunol 122:1-8. 2002
    ..These observations indicate that PVM and MM play a role during the early stages of EAE development...
  95. ncbi Tumoricidal activity of high-dose tumor necrosis factor-alpha is mediated by macrophage-derived nitric oxide burst and permanent blood flow shutdown
    Chandrakala Menon
    Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Int J Cancer 123:464-75. 2008
    ..We conclude that TNF causes tumor infiltrating, macrophage-derived iNOS-mediated tumor NO rise and sustained tumor blood flow shutdown, resulting in tumor ulceration in the responsive tumor...
  96. ncbi [Osteonecrosis of the jaw developing during bisphosphonate treatment]
    Eniko Udvardy
    Debreceni Egyetem, Orvos és Egészségtudományi Centrum, Fogorvosi Kar, ARC, Allcsont és Szájsebészeti Osztály, Debrecen
    Magy Onkol 52:81-7. 2008
    ..Regarding the growing number of ONJ cases in association with bisphosphonate therapy it is important for the professionals treating cancer patients to be aware of this phenomenon and the importance of prevention...
  97. ncbi Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma
    Nathan R Miselis
    Department of Pathology and Laboratory Medicine, Brown University, Box G E531, Providence, RI 02912, USA
    Mol Cancer Ther 7:788-99. 2008
    ..p. injection. These reductions in tumor burden are statistically significant and identify TAMs as an important host-derived cell that contributes to growth, invasion, and metastasis in diffuse malignant peritoneal mesothelioma...
  98. ncbi An immunomodulatory procedure that stabilizes transgene expression and permits readministration of E1-deleted adenovirus vectors
    A I Kuzmin
    Institute for Gene Therapy and Molecular Medicine, Mt. Sinai School of Medicine, New York, New York 10029, USA
    Mol Ther 3:293-301. 2001
    ..These experiments demonstrate that this treatment is transient and antigen-specific...
  99. ncbi Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion
    Takashi Yamamoto
    Department of Cellular Function, Division of Cellular and Molecular Pathology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 951 8510, Japan
    Cell Tissue Res 332:245-56. 2008
    ..This mouse model provides a useful tool for the study of effects of growth factor on Kupffer cell differentiation in vivo...
  100. ncbi Macrophage involvement in the kidney repair phase after ischaemia/reperfusion injury
    E Vinuesa
    Department of Experimental Pathology, IIBB CSIC, IDIBAPS, 08036, Barcelona, Spain
    J Pathol 214:104-13. 2008
    ..We conclude that macrophages induce renal regeneration after ischaemia/reperfusion, depending on the inflammatory milieu...
  101. ncbi Histidine decarboxylase-stimulating and inflammatory effects of alendronate in mice: involvement of mevalonate pathway, TNFalpha, macrophages, and T-cells
    Xue Deng
    Department of Molecular Regulation, Graduate School of Dentistry, Tohoku University, 4 1 Seiryo machi, Sendai, Japan
    Int Immunopharmacol 7:152-61. 2007
    ....

Research Grants12

  1. Role of Vitamin D in Dendritic Cell Immune Functions
    Matthew Griffin; Fiscal Year: 2004
    ....
  2. Organophosphates Modify Eosinophil and Nerve Interaction
    Becky Proskocil; Fiscal Year: 2008
    ..The observed effects of OPs on eosinophils and nerves will be measured in isolated cells. [unreadable] [unreadable] [unreadable]..
  3. Defibrotide for the treatment of severe hepatic veno-cc*
    Paul Richardson; Fiscal Year: 2007
    ..Abstract Not Provided ..
  4. VENTILATOR-ASSOCIATED ALVEOLAR EPITHELIAL INJURY
    James Frank; Fiscal Year: 2006
    ..This research and comprehensive career development plan will prepare me to become an independent investigator in the mechanisms of alveolar epithelial injury and ventilator-associated lung injury. ..
  5. Osteoporosis Prevention in Early Stage Breast Cancer
    Dawn Hershman; Fiscal Year: 2006
    ..abstract_text> ..
  6. Role of 15d-PGJ2 Hepatic Macrophages
    Cynthia Ju; Fiscal Year: 2005
    ..Furthermore, studies of inhibition of HO-1 and IL-10 will be carried out to determine functional association of 15d-PGJ2 with HO-1 and IL-10. ..
  7. Effect of Pertussis Toxin on Cough in Guinea Pig
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..abstract_text> ..
  8. Pertussis Toxin Trafficking and Processing in Cells
    NICHOLAS CARBONETTI; Fiscal Year: 2005
    ..Therefore the specific aims of this proposal are to investigate the trafficking, processing and transcytosis of PT in mammalian cells and the key features of this toxin that mediate these events. ..
  9. ADAM: Androgen Deprivation vs. Antiandrogen Monotherapy
    Matthew Smith; Fiscal Year: 2004
    ..In addition, this project will provide important insights into the relative contributions of testosterone and estrogen in bone metabolism, and maintenance of muscle size and strength in older men. ..
  10. Role of Pertussis Toxin in Bordetella pertussis infection
    Nicholas H Carbonetti; Fiscal Year: 2010
    ..pertussis infection will increase our understanding of the pathogenic mechanisms of this organism, and may lead to novel therapeutic approaches to combat pertussis infection and disease. ..
  11. ANGIOTENSIN AND CENTRAL NEUROHUMORAL ACTIVATION IN CHF
    Robert Felder; Fiscal Year: 2005
    ..This work will provide new information concerning the role of the central nervous system in the pathophysiology of CHF and will draw attention to the possibility of CNS directed drug therapy for heart failure. ..