technetium tc 99m medronate

Summary

Summary: A gamma-emitting radionuclide imaging agent used primarily in skeletal scintigraphy. Because of its absorption by a variety of tumors, it is useful for the detection of neoplasms.

Top Publications

  1. ncbi A new computer-based decision-support system for the interpretation of bone scans
    May Sadik
    Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Nucl Med Commun 27:417-23. 2006
  2. ncbi The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT
    Einat Even-Sapir
    Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Nucl Med 47:287-97. 2006
  3. ncbi Nonosseous abnormalities on bone scans
    Issa Loutfi
    Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Nucl Med Technol 31:149-53; quiz 154-6. 2003
  4. ncbi The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol
    Sherif I Heiba
    Nuclear Medicine Service, Nuclear Medicine Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Foot Ankle Surg 49:529-36. 2010
  5. ncbi Whole body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy
    M Ohta
    Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Nucl Med Commun 22:875-9. 2001
  6. ncbi Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions
    G J Cook
    Clinical Positron Emission Tomography Centre and Department of Oncology, Guys Hospital, United Medical and Dental Schools, London, United Kingdom
    J Clin Oncol 16:3375-9. 1998
  7. ncbi Global skeletal uptake of 99mTc-methylene diphosphonate (GSU) in patients affected by endocrine diseases: comparison with biochemical markers of bone turnover
    A Scillitani
    Division and Research Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Osteoporos Int 13:829-34. 2002
  8. ncbi Comparing whole body (18)F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer
    S N Yang
    Department of Radiation Therapy and Oncology, China Medical College Hospital, Taichung, Taiwan
    J Cancer Res Clin Oncol 128:325-8. 2002
  9. ncbi Quantitative measurements of bone remodeling using 99mTc-methylene diphosphonate bone scans and blood sampling
    Amelia E B Moore
    School of Medicine, King s College London, London, United Kingdom
    J Nucl Med 49:375-82. 2008
  10. ncbi Quantitative studies of bone in postmenopausal women using (18)F-fluoride and (99m)Tc-methylene diphosphonate
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Nucl Med 43:338-45. 2002

Detail Information

Publications237 found, 100 shown here

  1. ncbi A new computer-based decision-support system for the interpretation of bone scans
    May Sadik
    Department of Clinical Physiology, Sahlgrenska University Hospital, Goteborg, Sweden
    Nucl Med Commun 27:417-23. 2006
    ..To develop a completely automated method, based on image processing techniques and artificial neural networks, for the interpretation of bone scans regarding the presence or absence of metastases...
  2. ncbi The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT
    Einat Even-Sapir
    Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Nucl Med 47:287-97. 2006
    ..The aim of this study was to compare the detection of bone metastases by 99mTc-methylene diphosphonate (99mTc-MDP) planar bone scintigraphy (BS), SPECT, 18F-Fluoride PET, and 18F-Fluoride PET/CT in patients with high-risk prostate cancer...
  3. ncbi Nonosseous abnormalities on bone scans
    Issa Loutfi
    Department of Nuclear Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
    J Nucl Med Technol 31:149-53; quiz 154-6. 2003
    ....
  4. ncbi The optimized evaluation of diabetic foot infection by dual isotope SPECT/CT imaging protocol
    Sherif I Heiba
    Nuclear Medicine Service, Nuclear Medicine Division, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    J Foot Ankle Surg 49:529-36. 2010
    ..This combined imaging technique promises to beneficially impact diabetic patient care...
  5. ncbi Whole body PET for the evaluation of bony metastases in patients with breast cancer: comparison with 99Tcm-MDP bone scintigraphy
    M Ohta
    Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan
    Nucl Med Commun 22:875-9. 2001
    ..In conclusion, FDG-PET appears to be a powerful tool not only in the diagnosis of the primary lesion and soft tissue metastasis, but also in the diagnosis of bony metastasis among patients with breast cancer...
  6. ncbi Detection of bone metastases in breast cancer by 18FDG PET: differing metabolic activity in osteoblastic and osteolytic lesions
    G J Cook
    Clinical Positron Emission Tomography Centre and Department of Oncology, Guys Hospital, United Medical and Dental Schools, London, United Kingdom
    J Clin Oncol 16:3375-9. 1998
    ..We have compared 18FDG PET with 99mTc MDP bone scintigraphy in patients with skeletal metastases from breast cancer and have analyzed the data in subgroups based on radiographic characteristics of lesions...
  7. ncbi Global skeletal uptake of 99mTc-methylene diphosphonate (GSU) in patients affected by endocrine diseases: comparison with biochemical markers of bone turnover
    A Scillitani
    Division and Research Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Osteoporos Int 13:829-34. 2002
    ..The behavior of GSU and OC and U-DPD is non-uniform in disorders characterized by a marked uncoupling between bone formation and resorption...
  8. ncbi Comparing whole body (18)F-2-deoxyglucose positron emission tomography and technetium-99m methylene diphosphonate bone scan to detect bone metastases in patients with breast cancer
    S N Yang
    Department of Radiation Therapy and Oncology, China Medical College Hospital, Taichung, Taiwan
    J Cancer Res Clin Oncol 128:325-8. 2002
    ..We attempted to evaluate the usefulness of FDG-PET for detecting bone metastases in breast cancer and to compare FDG-PET results with bone scan findings...
  9. ncbi Quantitative measurements of bone remodeling using 99mTc-methylene diphosphonate bone scans and blood sampling
    Amelia E B Moore
    School of Medicine, King s College London, London, United Kingdom
    J Nucl Med 49:375-82. 2008
    ..3 y) before participation in a clinical trial of an osteoporosis therapy. The aim was to compare the consistency and accuracy of the 3 methods before their use in evaluating the subjects' response to treatment...
  10. ncbi Quantitative studies of bone in postmenopausal women using (18)F-fluoride and (99m)Tc-methylene diphosphonate
    Glen M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Nucl Med 43:338-45. 2002
    ..In this study we evaluated their use to quantify bone turnover in women receiving antiresorptive therapy compared with that of untreated control subjects...
  11. ncbi Age- and sex-related bone uptake of Tc-99m-HDP measured by whole-body bone scanning
    W Brenner
    Klinik für Nuklearmedizin, Christian Albrechts Universitat zu Kiel
    Nuklearmedizin 39:127-32. 2000
    ....
  12. ncbi Effects of 99mTc-MIBI and 99mTc-MDP administration on dual-energy X-ray absorptiometry bone mineral density measurements
    Gul Gumuser
    Department of Nuclear Medicine, Celal Bayar University, Manisa, Turkey
    Nucl Med Commun 30:445-8. 2009
    ....
  13. ncbi Gamut: soft tissue uptake of bone radiopharmaceuticals
    Murat Tuncel
    Department of Nuclear Medicine, Hacettepe University, Medical School, Ankara, Turkey
    Semin Nucl Med 33:334-7. 2003
  14. ncbi Assessment of regional changes in skeletal metabolism following 3 and 18 months of teriparatide treatment
    Amelia E B Moore
    King s College London, Guy s Campus, London, United Kingdom
    J Bone Miner Res 25:960-7. 2010
    ..This is the first study showing a direct metabolic effect of TPTD at different skeletal sites in vivo, as measured by tracer kinetics...
  15. ncbi Validation of ultrafiltration as a method of measuring free 99mTc-MDP
    Amelia E B Moore
    Department of Nuclear Medicine, Guy s Hospital, London, United Kingdom
    J Nucl Med 44:891-7. 2003
    ....
  16. ncbi Comparison of 18FDG-PET with 99mTc-HMDP scintigraphy for the detection of bone metastases in patients with breast cancer
    Koichiro Abe
    Department of Clinical Radiology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Nucl Med 19:573-9. 2005
    ..The purpose of this study was to compare the diagnostic accuracy of 18FDG-PET with bone scintigraphy in detecting bone metastasis in breast cancer patients...
  17. ncbi Sentinel lymph node imaging and research after bone scintigraphy in breast cancer patients
    P Bourgeois
    Service of Nuclear Medicine, Institut Jules Bordet, Universite Libre de Bruxelles, Belgium
    Breast 12:194-202. 2003
    ..It is concluded that the SLN technique can be accurately performed just after one BS...
  18. ncbi Bone scintiscanning in osteolytic lesions
    Shrikant Solav
    SPECT LAB, Nuclear Medicine Services, K 2 1 Erandawana Coop Society, Opposite Dinanath Mangeshkar Hospital, Pune
    Clin Nucl Med 29:12-20. 2004
    ..Interestingly, the scans in these patients helped to show if the lesions were monoostotic or polyostotic and, in some cases, ruled out malignant or infective etiology...
  19. ncbi Bone scintigraphy: procedure guidelines for tumour imaging
    Emilio Bombardieri
    Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
    Eur J Nucl Med Mol Imaging 30:BP99-106. 2003
  20. ncbi What is the role of bone scintigraphy in the diagnosis of infected joint prostheses?
    Ana Benítez Segura
    S Medicina Nuclear, CSUB, Hospital de Bellvitge, c Feixa Llarga s n, 08970 L Hospitalet de Llobregat, Barcelona, Spain
    Nucl Med Commun 25:527-32. 2004
    ..To analyse the role played by bone scintigraphy in the diagnosis of infected joint prostheses...
  21. ncbi A comparative study of 201Tl scintigraphy and three-phase bone scintigraphy following therapy in patients with bone and soft-tissue tumors
    Yoshihiro Nishiyama
    Department of Radiology, Faculty of Medicine, Kagawa University, Kita gun, Japan
    Ann Nucl Med 18:235-41. 2004
    ....
  22. ncbi 99mTc depreotide scan compared with 99mTc-MDP bone scintigraphy for the detection of bone metastases and prediction of response to hormonal treatment in patients with breast cancer
    Bieke Van Den Bossche
    Division of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
    Nucl Med Commun 25:787-92. 2004
    ....
  23. ncbi Biodistribution and pharmacokinetics of variously molecular sized 117mSn(II)-polyethyleneiminomethyl phosphonate complexes in the normal primate model as potential selective therapeutic bone agents
    Jan R Zeevaart
    Radiochemistry, South African Nuclear Energy Corporation NECSA, Pretoria, South Africa
    Arzneimittelforschung 54:340-7. 2004
    ..This paper relates the labelling, biodistribution and pharmacokinetics of various fractions of 117mSn-(II) PEI-MP in the normal primate model, and points to promising therapeutic possibilities...
  24. ncbi Frequency of skeletal metastases in nasopharyngeal carcinoma after initiation of therapy: should bone scans be used for follow-up?
    M Caglar
    Department of Nuclear Medicine, Hacettepe University Medical Faculty, Ankara, Turkey
    Nucl Med Commun 24:1231-6. 2003
    ..We can therefore recommend that bone scintigraphy be used in determining the presence of bone metastases, but its utilization should be preserved for those with nodal involvement...
  25. ncbi Evaluation of 67 Ga citrate and 99m Tc bone scintigraphy at initial examination for primary oral squamous cell carcinoma
    Kojiro Onizawa
    Department of Oral and Maxillofacial Surgery, Institute of Clinical Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Oral Maxillofac Surg 61:913-7. 2003
    ....
  26. ncbi Comparing whole body 18F-2-deoxyglucose positron emission tomography and technetium-99m methylene diophosphate bone scan to detect bone metastases in patients with non-small cell lung cancer
    T C Hsia
    Division of Pulmonary, Critical Care Medicine, China Medical College Hospital, Taichung, Taiwan
    Neoplasma 49:267-71. 2002
    ....
  27. ncbi Octreotide imaging plus bone scintigrams to optimally localize gastroenteropancreatic neuroendocrine tumors
    Alexandra Le Duc-Pennec
    Nuclear Medicine Department, Buc, France
    Clin Nucl Med 28:5-8. 2003
    ..They used a bicolor scale to display pairs of scintigrams to easily identify the distribution of both tracers...
  28. ncbi Acute hematogenous osteomyelitis of children: assessment of skeletal scintigraphy-based diagnosis in the era of MRI
    Leonard P Connolly
    Department of Radiology, Children s Hospital, Boston, Massachusetts 02115, USA
    J Nucl Med 43:1310-6. 2002
    ..This study evaluated a strategy in which skeletal scintigraphy is the primary and MRI a supplemental test...
  29. ncbi Are serial bone scans useful for the follow-up of clinically localized, low to intermediate grade prostate cancer managed with watchful observation alone?
    B K Yap
    Toronto Sunnybrook Regional Cancer Centre, Ontario, Canada
    BJU Int 91:613-7. 2003
    ..To assess the predictive value of serial bone scans as a surveillance tool for bone metastasis in men with clinically localized prostate cancer and managed with watchful observation...
  30. ncbi A reassessment of bone scintigraphy and commonly tested pretreatment biochemical parameters in newly diagnosed osteosarcoma
    M P M Stokkel
    Department of Nuclear Medicine, Leiden University Medical Center, P O Box 9600, 2300 RC Leiden, The Netherlands
    J Cancer Res Clin Oncol 128:393-9. 2002
    ..The aim of the present study was to investigate whether routinely tested biochemical parameters or additional parameters on bone scintigraphy could be identified which can select prognostic subgroups at the time of diagnosis...
  31. ncbi 99mTc-MIBI scintigraphy in untreated stage III multiple myeloma: comparison with X-ray skeletal survey and bone scintigraphy
    E Alper
    Department of Nuclear Medicine, Uludag University School of Medicine, Bursa, Turkey
    Nucl Med Commun 24:537-42. 2003
    ..Hence, in active MM patients, 99mTc-MIBI imaging has the potential to detect bone marrow disease that cannot be detected by skeletal survey and bone scintigraphy...
  32. ncbi Comparative whole-body 201Tl and bone scintigraphies for the detection of bone marrow involvement in multiple myeloma
    Y Nishiyama
    Department of Radiology, Faculty of Medicine, Kagawa Medical University, Kita gun, Kagawa, Japan
    Nucl Med Commun 24:977-86. 2003
    ..201Tl-chloride scintigraphy is a non-invasive tool, which may be more useful than bone scintigraphy for the diagnosis of multiple myeloma, and may be helpful in the follow-up of multiple myeloma...
  33. ncbi [Comparison of serum prostate specific antigen levels and bone scintigraphy in patients with prostate carcinoma]
    Jurgita Bielickaite
    Clinic of Radiology, Kaunas University of Medicine, Eiveniu 2, 3000 Kaunas, Lithuania
    Medicina (Kaunas) 39:867-71. 2003
    ..The bone scintigraphy should be performed in all patients with prostate specific antigen level above 18 ng/ml, but it is of limited value in patients with prostate specific antigen level below 18 ng/ml...
  34. ncbi The role of bone scan in the diagnosis of Jaffé-Lichtenstein-Uehlinger syndrome
    Daniela Chroustova
    Department of Nuclear Medicine, University Hospital Kralovske Vinohrady, Prague, Czech Republic
    Nucl Med Rev Cent East Eur 7:87-9. 2004
    ..A biopsy with histology was performed in consideration of bone scan findings and a confirmed final diagnosis...
  35. ncbi A clinical assessment of the relationship between bone scintigraphy and serum biochemical markers in hemodialysis patients
    Seiji Kurata
    Division of Nuclear Medicine and Department of Radiology, Kurume University School of Medicine, Fukuoka, Japan
    Ann Nucl Med 18:513-8. 2004
    ..In this study, we examined the correlation between quantifying bone scintigraphy and serum biochemical markers in hemodialysis patients...
  36. ncbi [18F-FDG PET and bone scintigraphy to search for bone metastasis of lung cancer]
    V Aflalo-Hazan
    Service de Medecine Nucleaire, Hopital Tenon, AP HP, 4, rue de la Chine, 75970 Paris Cedex 20
    Rev Pneumol Clin 62:164-9. 2006
    ..Using a computed tomography scan with the 18F-FDG PET could further limit the contribution of bone scintigraphy by providing more precision concerning foci identified on the PET scan...
  37. ncbi Diagnostic accuracy of bone metastases detection in cancer patients: comparison between bone scintigraphy and whole-body FDG-PET
    Ryota Fujimoto
    Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Japan
    Ann Nucl Med 20:399-408. 2006
    ..To evaluate the influence of PET on detection of bone metastasis, we compared the diagnostic accuracy of PET and conventional bone scintigraphy (BS) in a variety of cancer patients...
  38. ncbi SPECT/multislice low-dose CT: a clinically relevant constituent in the imaging algorithm of nononcologic patients referred for bone scintigraphy
    Einat Even-Sapir
    Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Nucl Med 48:319-24. 2007
    ..The purpose of this prospective study was to assess the role of SPECT/multislice low-dose (Msl) CT as a constituent in the imaging algorithm of nononcologic patients referred for 99mTc-methylene diphosphonate bone scintigraphy (BS)...
  39. ncbi Bone scintigraphy in the monitoring of treatment effect of bisphosphonates in bone metastatic breast cancer
    L Chavdarova
    Clinic of Nuclear Medicine, National Hospital of Oncology, Sofia, Bulgaria
    J BUON 11:499-504. 2006
    ..The aim of this retrospective study was to assess the possibilities of whole-body bone scintigraphy (WB BSc) in the monitoring of the effect of biphosphonate treatment in patients with breast cancer and bone metastases...
  40. ncbi 18F-fluorodeoxyglucose-positron emission tomography and bone scintigraphy for detecting bone metastases in patients with malignancies of the upper aerodigestive tract
    Mi Ra Kim
    Department of Otolaryngology, Bundang Jaesaeng General Hospital, Sungnam, South Korea
    Oral Oncol 44:148-52. 2008
    ..12.5%, P<0.001) and had lower mean SUVmax (2.4 vs. 5.6, P<0.001). FDG-PET is not more accurate than BS for detecting bone metastasis in patients with UADT cancer. Positive findings on FDG-PET or BS require further confirmation...
  41. ncbi Effect of age and gender on the number and distribution of sites in Paget's disease of bone
    M J Haddaway
    Department of Diagnostic Imaging, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, Shropshire SY10 7AG, UK
    Br J Radiol 80:532-6. 2007
    ..The lesser involvement at the axial sites in monostotic disease may lead to overestimation of the decline in PDB based on abdominal radiographs...
  42. ncbi The semiquantitative bone scintigraphy index correlates with serum tartrate-resistant acid phosphatase activity in breast cancer patients with bone metastasis
    Shih Hung Tsai
    Division of Hematology Oncology, Department of Medicine, Tri Service General Hospital, National Defense Medical Center, No 325 Cheng Kung Road, Sec 2, Neihu 114, Taipei, Taiwan
    Mayo Clin Proc 82:917-26. 2007
    ....
  43. ncbi AJR Teaching File: multiple symmetric abnormalities in a radionuclide bone scan
    Ba D Nguyen
    Department of Radiology, Mayo Clinic Scottsdale, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    AJR Am J Roentgenol 189:S32-4. 2007
  44. ncbi Skeletal PET with 18F-fluoride: applying new technology to an old tracer
    Frederick D Grant
    Division of Nuclear Medicine PET, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Nucl Med 49:68-78. 2008
    ..The favorable imaging performance and the clinical utility of (18)F-fluoride PET, compared with (99m)Tc-diphosphonate scintigraphy, support the reconsideration of (18)F-fluoride as a routine bone-imaging agent...
  45. ncbi The contribution of bone SPECT to the diagnosis of bone metastases in an African population
    Ahmed E Elmadani
    Institute of Nuclear Medicine, Molecular Biology and Oncology, University of Gezira, Wadi Medani, Sudan
    Nucl Med Commun 29:254-9. 2008
    ..This has not been demonstrated in an African population, however, where patients typically present with more advanced disease...
  46. ncbi [Procollagen-I, collagen telopeptide I, CEA, CA 15-3 as compared to bone scintigraphy in patients with breast cancer]
    Athanassios Zissimopoulos
    Medical School of Democritus University of Thrace, Alexandroupolis, Greece
    Hell J Nucl Med 9:60-4. 2006
    ..05). The sensitivity of PICP, ICTP, CEA and CA 15-3 was 28.1%, 48.6%, 78%, 42% respectively and their specificity was 83.9%, 94%, 65% and 86% respectively...
  47. ncbi Bone turnover markers and bone scintigraphy in the evaluation of the skeletal metastases
    Beata E Chrapko
    Chair and Department of Nuclear Medicine, Skubiszewski Medical University of Lublin, Poland
    Nucl Med Rev Cent East Eur 8:100-4. 2005
    ..The aim of this study was evaluation of the clinical usefulness of bone scintigraphy and of serum bone turnover marker levels in the assessment of skeletal metastases...
  48. ncbi Radioisotope bone scans in the preoperative staging of hepatopancreatobiliary cancer
    H Sheth
    University Department of Surgery, Royal Free Hospital, London, UK
    Br J Surg 92:203-7. 2005
    ..The aim of the study was to determine the value of radioisotope bone scans in the preoperative staging of patients with hepatopancreatobiliary (HPB) cancer...
  49. ncbi [Correlation in imaging techniques for the early detection of bone metastases in a case of breast cancer]
    Irena Raileanu
    Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicina, Disciplina de Biofizică si Medicină nucleară
    Rev Med Chir Soc Med Nat Iasi 108:210-3. 2004
    ..In conclusion, an extensive scintigraphic examination, including PET, is necessary to optimize the osteofil cancer metastases detection...
  50. ncbi Demonstration of large bladder diverticulum on bone scan
    Cheng Pei Chang
    Department of Nuclear Medicine, Taipei Veterans General Hospital, National Defense Medical Center, and National Yang Ming University School of Medicine, Taipei, Taiwan
    Clin Nucl Med 30:276-7. 2005
    ..Transverse magnetic resonance images showed a large diverticulum originating from the left lateral wall of the bladder. The pelvic findings on the bone scan were the result of tracer retained within this diverticulum...
  51. ncbi The potential use of 99mTc-MDP bone scans to plan high-activity 186Re-HEDP targeted therapy of bony metastases from prostate cancer
    David Binnie
    Institute of Cancer Research, Royal Marsden Hospital Foundation Trust, Sutton SM2 5PT, UK
    Cancer Biother Radiopharm 20:189-94. 2005
    ....
  52. ncbi Usefulness of whole PTH assay in patients with renal osteodystrophy--correlation with bone scintigraphy
    Hayato Kaida
    Division of Nuclear Medicine, PET Center and Department of Radiology, Kurume University School of Medicine, Fukuoka, Japan
    Ann Nucl Med 19:179-84. 2005
    ..As such, a whole PTH assay has recently been developed. The purpose of this study was to examine the usefulness of a whole PTH assay using the bone to soft tissue (B/ST) ratio on bone scintigraphy...
  53. ncbi Osteoblastic bone metastases in breast cancer: is not seeing believing?
    Ignac Fogelman
    Department of Nuclear Medicine, Guy s, King s and St Thomas School of Medicine, Guy s Campus, London, SE1 9RT, UK
    Eur J Nucl Med Mol Imaging 32:1250-2. 2005
  54. ncbi Relative roles of bone scintigraphy and positron emission tomography in assessing the treatment response of bone metastases
    J R Garcia
    Eur J Nucl Med Mol Imaging 32:1243-4. 2005
  55. ncbi Pitfalls of FDG-PET for the diagnosis of osteoblastic bone metastases in patients with breast cancer
    Takako Nakai
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Eur J Nucl Med Mol Imaging 32:1253-8. 2005
    ....
  56. ncbi The role of 99mTc(V)-DMSA scan as compared to 99mTc-MDP and CT scans in imaging the primary tumor and metastases of osteosarcoma
    Athanassios Zissimopoulos
    Dimokrition University School of Medicine, Nuclear Medicine Department, Alexandroupolis, Greece
    Hell J Nucl Med 8:162-4. 2005
    ..The 99mTc(V)-DMSA scan was found to be superior to the 99mTc-MDP and the CT scans in identifying metastases of osteosarcoma. Sensitivity was 100%, 86% and 98% respectively...
  57. ncbi Can 16-detector multislice CT exclude skeletal lesions during tumour staging? Implications for the cancer patient
    Ashley M Groves
    Department of Radiology, Addenbrooke s Hospital NHS Trust and the University of Cambridge, Hills Rd, Box 218, Cambridge, CB2 2QQ, UK
    Eur Radiol 16:1066-73. 2006
    ..Patients who have undergone full whole-body staging on 16-detector CT may not need additional skeletal scintigraphy. This should shorten the cancer patient's diagnostic pathway...
  58. ncbi Quality of planar whole-body bone scan interpretations--a nationwide survey
    May Sadik
    Department of Clinical Physiology, Sahlgrenska University Hospital, 413 45, Goteborg, Sweden
    Eur J Nucl Med Mol Imaging 35:1464-72. 2008
    ..The purpose of this study was to investigate, in a nationwide study, the inter-observer variation and performance in interpretations of bone scans regarding the presence or absence of bone metastases...
  59. ncbi [Assessment of solitary hot spots of bone scintigraphy in patients with extraskeletal malignancies]
    Y Tomoda
    Department of Radiology, University of Occupational and Environmental Health
    Kaku Igaku 38:721-6. 2001
    ..It was relatively higher in the location of pelvis, scapula and thoracic spine. Clinical symptoms, particularly local bone pain, were helpful to diagnose the solitary hot spot...
  60. ncbi Bone scintigraphy and the added value of SPECT (single photon emission tomography) in detecting skeletal lesions
    G Savelli
    Division of Nuclear Medicine, Istituto Nazionale Tumori, Milano, Italy
    Q J Nucl Med 45:27-37. 2001
    ..7% (4/6), negative predictive value 100% (41/41), accuracy 95.7% (45/47). In conclusion bone SPECT showed very good performances, in particular improving the predictive value of planar scan in the diagnosis of vertebral metastases...
  61. ncbi A case of a gigantic urine bladder due to prostate cancer obstruction on a technetium-99m methyl diphosphonate bone scan
    Melih Engin Erkan
    Hell J Nucl Med 10:120. 2007
  62. ncbi Unusual bilateral symmetrical osteolytic metastases visualized by bone scintigraphy
    Madhusudhan P Reddy
    Department of Radiology, Division of Nuclear Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Clin Nucl Med 27:299-301. 2002
  63. ncbi Visualization in the ipsilateral lymph nodes secondary to extravasation of a bone-imaging agent in the left hand: a case report
    W J Shih
    Nuclear Medicine Service, Lexington VA Medical Center, Lexington, KY 40511, USA
    J Nucl Med Technol 29:154-5. 2001
    ..This was caused by extravasation of the intravenous injection of bone-imaging agent in the dorsal part of the patient's hand...
  64. ncbi Fusion lymphoscintigraphy with a 24-hour Tc-99m MDP bone scan for sentinel lymph node detection and imaging
    V R Tatini
    Department of Nuclear Medicine, William Beaumont Hospital, Royal Oak, Michigan 48073-6769, USA
    Clin Nucl Med 26:53. 2001
    ..A Tc-99m MDP bone scan followed by lymphoscintigraphy should be considered in patients with breast carcinoma who will have both bone imaging and lymphoscintigraphy...
  65. ncbi Radionuclide three-phase whole-body bone imaging
    David C Yang
    Division of Nuclear Medicine, Department of Radiology, New York Methodist Hospital and Weill Medical College of Cornell University, New York, New York 11215, USA
    Clin Nucl Med 27:419-26. 2002
    ..To describe the radionuclide three-phase whole-body bone imaging (TPWBBI) technique and discuss the usefulness of its application...
  66. ncbi Tc-99m MDP and Tc-99m MIBI in the assessment of spondyloarthritis presenting as bone metastasis before treatment with infliximab
    Ali Hadi
    Departments of Rheumatology and Nuclear Medicine, Derriford Hospital, Plymouth, United Kingdom
    Clin Nucl Med 27:297-8. 2002
  67. ncbi Preserved value of bone scintigraphy for the detection of skeletal metastases in prostate cancer patients with low prostate-specific antigen levels: effect of hormonal therapy and poor histologic differentiation
    Meltem Caglar
    Hacettepe University Medical Faculty, Department of Nuclear Medicine, Ankara, Turkey
    Clin Nucl Med 27:532-3. 2002
  68. ncbi Incidental finding of upper extremity deep venous thrombosis on skeletal scintigraphy
    Partha Sinha
    Department of Diagnostic Radiology, University of Kentucky College of Medicine Chandler Medical Center, 800 Rose Street, Lexington, KY 40536 0293, USA
    Clin Nucl Med 27:283-4. 2002
  69. ncbi Comparison of 99mTc ciprofloxacin, 99mTc white blood cell and three-phase bone imaging in the diagnosis of hip prosthesis infections: improved diagnostic accuracy with extended imaging time
    M J Larikka
    LP Central Hospital Laboratory, Kemi, Finland
    Nucl Med Commun 23:655-61. 2002
    ..Current data indicate that 99mTc ciprofloxacin is a useful method for confirming hip prosthesis infection. The diagnostic efficiency of this method is improved when the imaging time is extended to 24 h post-injection of the tracer...
  70. ncbi Uncommon clinical course of multiple osteochondromatosis in a patient with a long-term history of Cushing's disease
    A Faggiano
    Department of Molecular and Clinical Endocrinology and Oncology, Federico II University of Naples, Italy
    Pituitary 4:187-93. 2001
    ....
  71. ncbi Correlation between radiation dose, synovial thickness, and efficacy of radiosynoviorthesis
    S Gratz
    Department of Nuclear Medicine and Orthopedics, Georg August University, Gottingen, Germany
    J Rheumatol 26:1242-9. 1999
    ..To correlate the therapeutic efficacy of radiosynoviorthesis (RSO) to radiation doses achieved...
  72. ncbi Dose variance associated with calibration and administration of radiopharmaceuticals
    R N Dansereau
    Department of Pharmacy, MC 85, Albany Medical Center Hospital, 43 New Scotland Avenue, Albany, NY 12208, USA
    Am J Health Syst Pharm 58:580-4. 2001
    ..In addition, over a four-month period, 101 samples of technetium Tc 99m medronate injection with a desired activity of 20 mCi were prepared in syringes; the radioactive dose in each ..
  73. ncbi Effects of the glucantime on the kinetic of biodistribution of radiopharmaceuticals in Wistar rats
    C M C Xavier Holanda
    Universidade Federal do Rio Grande do Norte, Centro de Biociencias, Departamento de Microbiologia e Parasitologia, Av Salgado Filho, 3000, 59078 970, Natal, RN, Brazil
    Cell Mol Biol (Noisy-le-grand) 48:761-5. 2002
    ..05). These results could be associated with the biological effects and/or metabolization of the studied drug...
  74. ncbi Comparison of Tc-99m methylene diphosphonate, Tc-99m human immune globulin, and Tc-99m-labeled white blood cell scintigraphy in the diabetic foot
    S N Unal
    Department of Nuclear Medicine, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
    Clin Nucl Med 26:1016-21. 2001
    ....
  75. ncbi Diagnosis of osteomyelitis in the diabetic foot with a 99mTc-HMPAO leucocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy
    J Y Poirier
    Service d endocrinologie diabétologie, CHU Rennes, France
    Diabetes Metab 28:485-90. 2002
    ..The aim of this prospective study was to assess the role of 99mTc-HMPAO leucocyte scintigraphy combined with a 99mTc-MDP bone scintigraphy in the diagnosis of the diabetic foot infection (HMPAO-Leu/MDP)...
  76. ncbi Bilateral stress fractures of femoral necks on bone scans
    Mehrossadat Alavi
    Nuclear, Medicine Depatment, Namazee, Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
    Hell J Nucl Med 13:76. 2010
    ..The literature describes very few cases of bilateral femoral neck stress fractures in healthy adolescents. There has not been reported the case within a span of 3 months of exercise...
  77. ncbi Necrotizing (malignant) external otitis
    Ophir Handzel
    Department of Otolaryngology Head and Neck Surgery, Kaplan Medical Center, Rehovot, Israel
    Am Fam Physician 68:309-12. 2003
    ..Imaging studies may include computed tomographic scanning, technetium Tc 99m medronate bone scanning, and gallium citrate Ga 67 scintigraphy...
  78. ncbi 18F-FDG hybrid PET in patients with suspected spondylitis
    S Gratz
    Department of Nuclear Medicine, Georg August University of Gottingen, Germany
    Eur J Nucl Med Mol Imaging 29:516-24. 2002
    ....
  79. ncbi Incremental diagnostic value of 99mTc methylene diphosphonate bone SPECT in patients with patellofemoral pain disorders
    M Lorberboym
    Department of Nuclear Medicine, Edith Wolfson Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Nucl Med Commun 24:403-10. 2003
    ..SPECT significantly improves the detection of maltracking of the patella and the ensuing increased lateral patellar compression syndrome. This information could be used to treat patellofemoral problems more effectively...
  80. ncbi Early experience with fluorine-18 sodium fluoride bone PET in young patients with back pain
    Ruth Lim
    Division of Nuclear Medicine, Department of Radiology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Pediatr Orthop 27:277-82. 2007
    ..Experience with pediatric PET is sparse, primarily in oncology. This study assesses the role of 18F NaF in evaluating young patients with back pain...
  81. ncbi Combined 18F-FDG and 11C-methionine PET scans in patients with newly progressive metastatic prostate cancer
    Rodolfo Nunez
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    J Nucl Med 43:46-55. 2002
    ..Our aim was to detect the proportion of bone and soft-tissue lesions that represent metabolically active tumor sites in patients with progressive metastatic prostate cancer...
  82. ncbi 99mTc-MDP bone SPECT for the evaluation of sternal ischaemia following internal mammary artery dissection
    M Lorberboym
    Department of Nuclear Medicine, The Edith Wolfson Medical Center, Holon, Israel
    Nucl Med Commun 23:47-52. 2002
    ..This does not occur when the IMA is skeletonized or semiskeletonized. Hence, it may be prudent to minimize dissection during mobilization of the IMA to decrease the likelihood of post-operative sternal complications...
  83. ncbi Sensory-motor polyradiculoneuropathy as the first manifestation of sternum bone plasmacytoma only revealed by bone scintigraphy
    R Velasco
    Department of Neurology, Hospital Universitari de Bellvitge, Feixa Llarga s n, 08907, LHospitalet, Barcelona, Spain
    Neuromuscul Disord 19:59-61. 2009
    ..Biopsy of the lesion demonstrated a plasmacytoma. We emphasize that 99mTc-MDP scintigraphy can be a useful screening procedure for patients with polyradiculoneuropathy and occult bone plasmacytoma...
  84. ncbi Treatment of bone pain secondary to metastases using samarium-153-EDTMP
    Elba Cristina Sá de Camargo Etchebehere
    Division of Nuclear Medicine, Department of Radiology, and Research Committee, School of Medical Sciences, Universidade Estadual de Campinas UNICAMP, Campinas, Sao Paulo, Brazil
    Sao Paulo Med J 122:208-12. 2004
    ..More than 50% of patients with prostate, breast or lung cancer will develop painful bone metastases. The purpose of treating bone metastases is to relieve pain, reduce the use of steroids and to maintain motion...
  85. ncbi Altered lower limb vascular perfusion in patients with sciatica secondary to disc herniation
    J Y Maigne
    Department of Rehabilitation and Orthopedic Medicine, Hotel Dieu University Hospital, Paris, France
    Spine (Phila Pa 1976) 21:1657-60. 1996
    ..CONCLUSION: Vascular perfusion abnormalities observed in patients with sciatica secondary to disc herniation may be more important than previously considered and possibly result from alteration in sympathetic vascular autoregulation...
  86. ncbi Superiority of fluorodeoxyglucose positron emission tomography to other functional imaging techniques in the evaluation of metastatic SDHB-associated pheochromocytoma and paraganglioma
    Henri J L M Timmers
    Reproductive Biology and Medicine Branch, National Institutes of Child Health and Human Development, Bethesda MD 20892 1109, USA
    J Clin Oncol 25:2262-9. 2007
    ..Timely and accurate localization of these aggressive tumors is critical for guiding optimal treatment. Our aim is to evaluate the performance of functional imaging modalities in the detection of metastatic lesions of SDHB-associated PGL...
  87. ncbi Is SPECT/CT with a hybrid camera useful to improve scintigraphic imaging interpretation?
    Orazio Schillaci
    Department of Biopathology and Diagnostic Imaging, University Tor Vergata, Rome, Italy
    Nucl Med Commun 25:705-10. 2004
    ....
  88. ncbi Osteolytic lesions as a presenting sign of acute myeloid leukemia
    C S Lima
    Hematology and Hemotherapy Center, State University of Campinas, Sao Paulo, Brazil
    Haematologia (Budap) 30:325-31. 2000
    ..It also provides additional data as evidence that although osteolytic lesions indicate an adverse prognosis in AML, local irradiation results symptomatic relief...
  89. ncbi [Usefulness of bone imaging in diagnosis of sternocostoclavicular hyperostosis]
    H Sakata
    Department of Radiology, School of Medicine, Fukuoka University, Japan
    Radioisotopes 38:76-9. 1989
    ..Bone imaging revealed also radionuclide accumulations in other bones such as the vertebrae, femur or sacroiliac joints in ten (14 sites) of 33 cases. Bone scintigraphy was useful in the diagnosis of sternoclavicular hyperostosis...
  90. ncbi A direct in vivo measurement of 99mTc-methylene diphosphonate protein binding
    G M Blake
    Department of Nuclear Medicine, Guy s Hospital, London, UK
    Nucl Med Commun 24:829-35. 2003
    ..The results confirm that the fraction of free 99mTc-MDP varies with time and shows significant differences between individuals, which are dependent on GFR and K(bone) amongst other factors...
  91. ncbi Metastatic osteosarcoma to the liver after treatment for synovial sarcoma: a case report
    N C Daw
    Department of Hematology Oncology, St Jude Children s Research Hospital, and the University of Tennessee, Memphis, College of Medicine, Memphis, Tennessee, USA
    Pediatr Hematol Oncol 18:123-8. 2001
    ..The risk of radiation-induced osteosarcoma should always be considered in decisions about treatment for soft-tissue sarcoma...
  92. ncbi Clinical approach to renal study incidental to 99mTc-MDP bone scintigraphy
    T Takayama
    Department of Clinical Radiological Technology, School of Health Sciences, Kanazawa University, Japan
    Ann Nucl Med 15:237-45. 2001
    ..009X - 0.111 and Y = 1.034X - 0.714, respectively. In conclusion, 99mTc-MDP can be used as a supplement to evaluate renal function incidental to the survey of bone metastases in patients with malignant tumor...
  93. ncbi Correlation of 99mTc-sestamibi uptake with blood-pool and osseous phase 99mTc-MDP uptake in malignant bone and soft-tissue tumours
    Z Ozcan
    Ege University Medical Faculty, Department of Nuclear Medicine, Izmir, Turkey
    Nucl Med Commun 22:679-83. 2001
    ..Better delineation of tumour outlines and cellular activity seems to be an advantage of 99mTc-MIBI scintigraphy which may be helpful in the evaluation of musculoskeletal tumours...
  94. ncbi Frequency of pulmonary mineralization and hypoxemia in 21 dogs with pituitary-dependent hyperadrenocorticism
    C R Berry
    Department of Anatomy, Physiological Sciences and Radiology, North Carolina State University, College of Veterinary Medicine, Raleigh, USA
    J Vet Intern Med 14:151-6. 2000
    ..5 +/- 0.4 versus 0.4 +/- 0.1, P = .16). Causes of hypoxemia other than pulmonary thromboembolism should be considered in dogs with PDH. Pulmonary mineralization may contribute to hypoxemia in dogs with PDH...
  95. ncbi Correlation between computed tomography and bone single photon emission-computed tomography scintigraphy in patients with chronic rhinosinusitis
    Peter J Catalano
    Department of Otolaryngology, Lahey Clinic, Burlington, Massachusetts, USA
    Am J Rhinol 21:433-8. 2007
    ..No studies, however, have documented the correlation between these two imaging modalities in CRS...
  96. ncbi Somatostatin receptor (SSTR) scintigraphy in patients with osteosarcoma
    Stefano Ferrari
    Musculoskeletal Oncology Department of the Istituto Ortopedico Rizzoli, Bologna, Italy
    Cancer Biother Radiopharm 18:847-51. 2003
    ....
  97. ncbi Characterization of focal bone lesions in the axial skeleton: performance of planar bone scintigraphy compared with SPECT and SPECT fused with CT
    Klaus Strobel
    Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, Zurich, Switzerland, 8091
    AJR Am J Roentgenol 188:W467-74. 2007
    ..The purpose of this study was to evaluate the diagnostic performance of planar 99mTc methylene diphosphonate bone scintigraphy compared with SPECT and SPECT fused with CT in patients with focal bone lesions of the axial skeleton...
  98. ncbi Effects of acepromazine on three-phase 99mTc-MDP bone imaging in 11 horses
    Mauricio Solano
    Department of Clinical Sciences, Tufts University, School of Veterinary Medicine, North Grafton, MA 01536, USA
    Vet Radiol Ultrasound 46:437-42. 2005
    ..As expected, the vasodilatation and increased blood flow associated with intravenous injection of acepromazine affected the count density of the vascular phase of the bone scan...
  99. ncbi [Frostbite of the upper and lower limbs in an expert mountain climber: the value of bone scan in the prediction of amputation level]
    J Banzo
    Servicio de Medicina Nuclear, Hospital Clinico Universitario de Zaragoza, Spain
    Rev Esp Med Nucl 21:366-9. 2002
    ..Bone scan is indicated in the evaluation of frostbite injuries and helps to establish the prognosis early...
  100. ncbi Extraosseous accumulation of bone scanning agents in malignant brain tumors: comparison to semi-quantitative evaluation with 99mTc SPECT/201Tl SPECT and histological findings
    Aya Suzuki
    Oral Surgery, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University
    Ann Nucl Med 17:387-92. 2003
    ..Tc-T/N had no significant correlation with any of early-, delayed-T/N or T/S. In conclusion, there was no significant correlation between Tc and Tl uptakes by malignant brain tumors in semi-quantitative evaluation...
  101. ncbi [Carcinoid tumor and bone metastases: diagnosis by somatostatin receptor scintigraphy]
    J Banzo
    Servicio de Medicina Nuclear, Hospital Clinico Universitario Lozano Blesa Zaragoza
    Rev Esp Med Nucl 23:394-402. 2004
    ..The aim of this study has been to retrospectively assess the usefulness of 111In-DTPAOC scintigraphy in the detection of bone metastases (BM) in patients diagnosed of carcinoid tumour (CaT)...

Research Grants7

  1. Simultaneous Tc-99m-MDP/I-123-MIBG Imaging of Neuroblastoma Using SPECT-CT
    Jinsong Ouyang; Fiscal Year: 2011
    ....
  2. Novel Agents for Detecting/Monitoring of Bone Metastasis
    Xiankai Sun; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  3. Markers of Progression of Knee Osteoarthritis
    STEVEN MAZZUCA; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Effect of Diabetes on Bone Integration of Implants
    Michael McCracken; Fiscal Year: 2002
    ..This knowledge may lead to bioengineered materials which will modify and improve bone healing response in diabetic patients who receive implants. ..
  5. Periodontal Disease and Rheumatoid Arthritis
    Michael McCracken; Fiscal Year: 2005
    ..Furthermore, it is hypothesized that among patients with rheumatoid arthritis, an association exists between the rate of progression of inflammatory arthritis and the progression of periodontal disease. ..
  6. PATIENT SPECIFIC MODELS IN LUNG CANCER SCREENING WITH CT
    Matthew Brown; Fiscal Year: 2004
    ..4] To compare radiologist accuracy and interpretation times of HR-hCT scans, both with and without assistance from the automated detection system, against pre-existing nodule detection methods. ..
  7. SYNTHESIS AND EVALUATION OF BORONATED FOLATES FOR BNCT
    Werner Tjarks; Fiscal Year: 2001
    ..To evaluate the therapeutic efficacy for BNCT of those folic acid conjugates having favorable in vivo tumor-localizing properties. ..