ethylmercury compounds

Summary

Summary: Organic mercury compounds in which the mercury is attached to an ethyl group.

Top Publications

  1. ncbi Hair mercury in breast-fed infants exposed to thimerosal-preserved vaccines
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, Porto Velho, RO, Brazil
    Eur J Pediatr 166:935-41. 2007
  2. ncbi Prenatal and postnatal mercury exposure, breastfeeding and neurodevelopment during the first 5 years
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, RO, Brasil
    Cogn Behav Neurol 22:134-41. 2009
  3. ncbi Automated speciation of mercury in the hair of breastfed infants exposed to ethylmercury from thimerosal-containing vaccines
    Jose G Dorea
    Universidade de Brasilia, C P 04322, 70919 970, Brasilia, Federal District, Brasil
    Biol Trace Elem Res 140:262-71. 2011
  4. ncbi [Significance of biological indicators of mercury exposure]
    P Apostoli
    Cattedra di Igiene Industriale, Universita degli Studi di Brescia, p le Spedali Civili 1, 25123 Brescia
    Med Lav 94:231-41. 2003
  5. ncbi Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data
    Sarah K Parker
    Department of Pediatrics, Children s Hospital and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatrics 114:793-804. 2004
  6. ncbi Exposure to mercury during the first six months via human milk and vaccines: modifying risk factors
    Jose G Dorea
    Faculty of Health Sciences, Universidade de Brasilia, Brasilia, Brazil
    Am J Perinatol 24:387-400. 2007
  7. ncbi Simultaneous determination of trace levels of ethylmercury and methylmercury in biological samples and vaccines using sodium tetra(n-propyl)borate as derivatizing agent
    Darija Gibicar
    Department of Environmental Sciences, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia
    Anal Bioanal Chem 388:329-40. 2007
  8. ncbi Mercury in infants given vaccines containing thiomersal
    Neal A Halsey
    Lancet 361:698-9; author reply 699. 2003
  9. ncbi Prospective screening for thimerosal hypersensitivity: a pilot study
    A Gordon
    School of Optometry The Medical Center, University of Alabama, Birmingham
    Am J Optom Physiol Opt 65:147-50. 1988
  10. ncbi Toxic effects of ophthalmic preservatives on cultured rabbit corneal epithelium
    P A Simmons
    Department of Basic and Visual Sciences, Southern California College of Optometry, Fullerton
    Am J Optom Physiol Opt 65:867-73. 1988

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Detail Information

Publications96

  1. ncbi Hair mercury in breast-fed infants exposed to thimerosal-preserved vaccines
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, Porto Velho, RO, Brazil
    Eur J Pediatr 166:935-41. 2007
    ..We speculate that dose and parenteral mode of thimerosal-EtHg exposure modulated the relative increase in hair-Hg of breast-fed infants at 6 months of age...
  2. ncbi Prenatal and postnatal mercury exposure, breastfeeding and neurodevelopment during the first 5 years
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, RO, Brasil
    Cogn Behav Neurol 22:134-41. 2009
    ..We evaluated the association between infant hair-Hg and Gesell schedules (GS)...
  3. ncbi Automated speciation of mercury in the hair of breastfed infants exposed to ethylmercury from thimerosal-containing vaccines
    Jose G Dorea
    Universidade de Brasilia, C P 04322, 70919 970, Brasilia, Federal District, Brasil
    Biol Trace Elem Res 140:262-71. 2011
    ..050, 0.10, and 0.10 ng g⁻¹ for MeHg, Hg(II), and EtHg, respectively, for a 20-mg sample. Specific limits depend on the amount of sample extracted and the amount of extract injected...
  4. ncbi [Significance of biological indicators of mercury exposure]
    P Apostoli
    Cattedra di Igiene Industriale, Universita degli Studi di Brescia, p le Spedali Civili 1, 25123 Brescia
    Med Lav 94:231-41. 2003
    ..It was considered appropriate to update of the significance and use of the different mercury exposure indicators...
  5. ncbi Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data
    Sarah K Parker
    Department of Pediatrics, Children s Hospital and University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    Pediatrics 114:793-804. 2004
    ....
  6. ncbi Exposure to mercury during the first six months via human milk and vaccines: modifying risk factors
    Jose G Dorea
    Faculty of Health Sciences, Universidade de Brasilia, Brasilia, Brazil
    Am J Perinatol 24:387-400. 2007
    ..Because of the increase in environmental pollution and the need to produce cheap and safe vaccines, there is a need to address the uncertainty of vaccine-ethylmercury risk of toxicity and Hg exposure during breastfeeding...
  7. ncbi Simultaneous determination of trace levels of ethylmercury and methylmercury in biological samples and vaccines using sodium tetra(n-propyl)borate as derivatizing agent
    Darija Gibicar
    Department of Environmental Sciences, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia
    Anal Bioanal Chem 388:329-40. 2007
    ..This work illustrates the possibility of using hair and blood as potential biomarkers of exposure to thiomersal...
  8. ncbi Mercury in infants given vaccines containing thiomersal
    Neal A Halsey
    Lancet 361:698-9; author reply 699. 2003
  9. ncbi Prospective screening for thimerosal hypersensitivity: a pilot study
    A Gordon
    School of Optometry The Medical Center, University of Alabama, Birmingham
    Am J Optom Physiol Opt 65:147-50. 1988
    ..Prospective patch testing for thimerosal hypersensitivity was neither clinically valuable nor sensitive in this particular sample...
  10. ncbi Toxic effects of ophthalmic preservatives on cultured rabbit corneal epithelium
    P A Simmons
    Department of Basic and Visual Sciences, Southern California College of Optometry, Fullerton
    Am J Optom Physiol Opt 65:867-73. 1988
    ..These results suggest that use of ophthalmic preparations containing these chemicals may affect the metabolic and proliferative capacity of the corneal epithelium adversely...
  11. ncbi [Lateral ligament replacement of the ankle joint--cialit graft or tendon graft? A comparative clinical study from the Balgrist Orthopedic University Hospital, Zürich]
    M F Waldis
    Orthopädische Universitätsklinik Balgrist, Zurich
    Z Orthop Ihre Grenzgeb 126:416-9. 1988
    ..This observation demands that no surgical technique should be employed that could interfere with the function of proprioceptive or constraining structures...
  12. ncbi Multiple effects of ethylmercurithiosalicylate on the metabolization of arachidonic acid by human neutrophils
    M Stüning
    Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Arbeitsgruppe Infektabwehrmechanismen, Ruhr Universitat, Bochum, FRG
    Prostaglandins Leukot Essent Fatty Acids 32:1-7. 1988
    ..LTA4 hydrolase activity was not affected. The inhibitory effects of thimerosal occurred instantaneously. The effects of the drug were not influenced by the concentration of the stimulus Ca-ionophore A23187...
  13. ncbi Perinatal multiple exposure to neurotoxic (lead, methylmercury, ethylmercury, and aluminum) substances and neurodevelopment at six and 24 months of age
    Rejane C Marques
    Federal University of Rio de Janeiro, Campus Macaé, CEP 27930 560 RJ, Brazil
    Environ Pollut 187:130-5. 2014
    ..PDI was positively affected by breastfeeding and negatively affected by ethylmercury. Milestone achievements were negatively affected by breast-milk Pb (age of walking) and by HHg (age of talking). ..
  14. ncbi Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism
    Cristofer S Price
    Abt Associates Inc, Cambridge, MA, USA
    Pediatrics 126:656-64. 2010
    ....
  15. ncbi Ethyl mercury poisoning during a protein A immunoadsorption treatment
    Michael Koch
    Center of Nephrology, Mettmann, Germany
    Am J Kidney Dis 47:e31-4. 2006
    ....
  16. ncbi Milestone achievement and neurodevelopment of rural Amazonian toddlers (12 to 24 months) with different methylmercury and ethylmercury exposure
    Jose G Dorea
    a Department of Nutrition, Universidade de Brasilia, Brasilia, Brazil
    J Toxicol Environ Health A 77:1-13. 2014
    ....
  17. ncbi Zinc ions cause the thimerosal-induced signal of fluorescent calcium probes in lymphocytes
    Hajo Haase
    Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Cell Calcium 45:185-91. 2009
    ....
  18. ncbi Methylmercury and inorganic mercury determination in blood by using liquid chromatography with inductively coupled plasma mass spectrometry and a fast sample preparation procedure
    Jairo L Rodrigues
    Laboratorio de Toxicologia e Essencialidade de Metais, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, SP, Brazil
    Talanta 80:1158-63. 2010
    ..Finally, after the application of the proposed method, we demonstrated an interesting in vivo ethylmercury conversion to inorganic mercury...
  19. ncbi A reliable method to determine methylmercury and ethylmercury simultaneously in foods by gas chromatography with inductively coupled plasma mass spectrometry after enzymatic and acid digestion
    Stephen Wai Cheung Chung
    Food Research Laboratory, Centre for Food Safety, Food and Environmental Hygiene Department, 382 Nam Cheong Street, Hong Kong, China
    J Chromatogr A 1218:1260-5. 2011
    ..It shown clearly that IDMS analysis got improvement in precision and accuracy, however, EtHg cannot be analyze simultaneously and the cost of analysis is higher...
  20. ncbi Fast speciation of mercury in seawater by short-column high-performance liquid chromatography hyphenated to inductively coupled plasma spectrometry after on-line cation exchange column preconcentration
    Xiao yu Jia
    State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun 130022, China
    Talanta 88:724-9. 2012
    ..008ngL(-1) for EtHg(+) (as Hg), respectively. With the established method, three seawater samples were also analyzed, and all the three mercury species have been found in each sample, albeit at a very low concentration...
  21. ncbi Toxic effects of three mercurial compounds on survival, and histology of the kidney of the catfish Clarias batrachus (L.)
    R Kirubagaran
    Centre of Advanced Study in Zoology, Banaras Hindu University, Varanasi, India
    Ecotoxicol Environ Saf 15:171-9. 1988
    ..Regeneration was noticed in the 90-day HgCl2-exposed group. After 180 days of exposure, however, histology of the kidney appeared normal in all the groups...
  22. ncbi [Multicenter survey related to the frequency of positive patch tests with mercury and thiomersal]
    J M Lachapelle
    Unité de Dermatologie Professionnelle et de l Environnement, Universite Catholique de Louvain, Bruxelles, Belgium
    Ann Dermatol Venereol 115:793-6. 1988
    ..As far as cosmetics are concerned, the use of mercurials (chemical nature and concentration) is restricted by a Recommendation of the European Council...
  23. ncbi Thiomersal keratoconjunctivitis, frequency, clinical spectrum and diagnosis
    N Wilson-Holt
    Moorfields Eye Hospital, London
    Eye (Lond) 3:581-7. 1989
    ..Symptoms were also seen in two patients who were hard lens wearers. In such atypical cases, diagnosis may be difficult but can be aided by the use of topical challenge with thiomersal...
  24. pmc Retention of mercurial preservatives in desiccated biological products
    J R Pemberton
    J Clin Microbiol 2:549-51. 1975
    ..A variety of bacterins, vaccines, and antisera retained greater than 90% of their original level of mercurial preservative after lyophilization, and this might influence certain uses of these products...
  25. ncbi Degradation of methyl and ethyl mercury into inorganic mercury by oxygen free radical-producing systems: involvement of hydroxyl radical
    I Suda
    Department of Pharmacology, Kumamoto University Medical School, Japan
    Arch Toxicol 65:129-34. 1991
    ..These results suggested that .OH, but not O2- and H2O2, might be the oxygen free radical mainly responsible for the degradation of MeHg and EtHg...
  26. ncbi Separation of SH-modified myosin subfragment-1 (A1) isozyme into two distinct equimolar fractions by an affinity chromatography
    Y Emoto
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka
    J Biochem 103:172-6. 1988
    ..These results demonstrate that the active site heterogeneity in SH-modified S1(A1) had no intrinsic origin in the unmodified S1: it was introduced by the SH-modification, but by an unknown mechanism(s) other than incomplete modification...
  27. ncbi Estimating human indoor exposure to elemental mercury from broken compact fluorescent lamps (CFLs)
    T Salthammer
    Fraunhofer WKI, Department of Material Analysis and Indoor Chemistry, Braunschweig, Germany
    Indoor Air 22:289-98. 2012
    ..Acute health effects would only be expected if the mercury is not removed immediately. Careful collection and disposal of the lamp fragments would also prevent dwellers from the risk of long-term exposure...
  28. ncbi [Mercury speciation in aquatic products analyzed by liquid chromatography cold vapor atomic fluorescence spectrometry]
    Xiaohong Shang
    Institute for Nutrition and Food Safety, China CDC, Beijing, 100021, China
    Wei Sheng Yan Jiu 39:321-5. 2010
    ....
  29. ncbi Selective determination method for measurement of methylmercury and ethylmercury in soil/sediment samples using high-performance liquid chromatography-chemiluminescence detection coupled with simple extraction technique
    Hitoshi Kodamatani
    Division of Earth and Environmental Science, Graduate School of Science and Engineering, Kagoshima University, 1 21 35 Korimoto, Kagoshima 890 0065, Japan
    J Chromatogr A 1288:155-9. 2013
    ..A preliminary study of the relationship between environmental mercury concentrations and MeHg(+) production was performed...
  30. ncbi Speciation analysis of mercury in natural water and fish samples by using capillary electrophoresis-inductively coupled plasma mass spectrometry
    Yunqiang Zhao
    Key Laboratory of Analysis and Detection for Food Safety of Ministry of Education, Fujian Provincial Key Lab of Analysis and Detection for Food Safety, Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China
    Talanta 89:280-5. 2012
    ..Our results showed that dried muscle of T. anchovy contained only one species of mercury, MeHg, indicating that MeHg is easier to be accumulated by aquatic organisms...
  31. pmc Neurodevelopment of Amazonian infants: antenatal and postnatal exposure to methyl- and ethylmercury
    Jose G Dorea
    Department of Nutrition, University of Brasilia, 70919 970 Brasilia, DF, Brazil
    J Biomed Biotechnol 2012:132876. 2012
    ..Results should be interpreted with caution because of unaccounted variables...
  32. ncbi Sensitive determination method for mercury ion, methyl-, ethyl-, and phenyl-mercury in water and biological samples using high-performance liquid chromatography with chemiluminescence detection
    Hitoshi Kodamatani
    Division of Earth and Environmental Sciences, Graduate School of Science and Engineering, Kagoshima University, Kagoshima 890 0065, Japan
    Anal Sci 28:959-65. 2012
    ..The determination results were in good agreement with the values of the certified reference materials...
  33. pmc Localizing organomercury uptake and accumulation in zebrafish larvae at the tissue and cellular level
    Malgorzata Korbas
    Department of Geological Sciences, University of Saskatchewan, 114 Science Place, Saskatoon, Saskatchewan S7N 5E2, Canada
    Proc Natl Acad Sci U S A 105:12108-12. 2008
    ..This novel approach is a powerful tool for directly investigating the molecular toxicology of heavy metals, and should be equally applicable to the study of a wide range of elements in developing embryos...
  34. doi Modeling neurodevelopment outcomes and ethylmercury exposure from thimerosal-containing vaccines
    Jose G Dorea
    Toxicol Sci 103:414-5; author reply 416. 2008
  35. ncbi Zinc(II), cadmium(II), mercury(II), and ethylmercury(II) complexes of phosphinothiol ligands
    P Fernandez
    Departamento de Quimica Inorganica, Universidad de Santiago de Compostela, 15782, Santiago de Compostela, Spain
    Inorg Chem 47:2121-32. 2008
    ..The molecular structures of 1, 2, 4, 7, and 10 have also been studied by means of density functional theory (DFT) calculations...
  36. ncbi Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines
    Michael E Pichichero
    Department of Microbiology Immunology, Pediatrics, and Medicine, University of Rochester, Rochester, New York 14642, USA
    Pediatrics 121:e208-14. 2008
    ..We conducted a pharmacokinetic study to assess blood levels and elimination of ethyl mercury after vaccination of infants with thimerosal-containing vaccines...
  37. ncbi Involvement of calcium in the thimerosal-stimulated formation of leukotriene by fMLP in human polymorphonuclear leukocytes
    A Hatzelmann
    Faculty of Biology, University of Konstanz, Federal Republic of Germany
    Biochem Pharmacol 39:559-67. 1990
    ..Our results suggest that thimerosal may provide a model for leukotriene formation under pathophysiological conditions when SH-group oxidation leads to increased intracellular Ca2(+)-levels...
  38. ncbi Amalgam study
    Jose G Dorea
    J Am Dent Assoc 138:1536-7; author reply 1537. 2007
  39. ncbi A review of Thimerosal (Merthiolate) and its ethylmercury breakdown product: specific historical considerations regarding safety and effectiveness
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Toxicol Environ Health B Crit Rev 10:575-96. 2007
    ..The ubiquitous and largely unchecked place of Thimerosal in pharmaceuticals, therefore, represents a medical crisis...
  40. ncbi Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years
    William W Thompson
    National Center for Immunizations and Respiratory Diseases, Influenza Division, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    N Engl J Med 357:1281-92. 2007
    ..It has been hypothesized that early exposure to thimerosal, a mercury-containing preservative used in vaccines and immune globulin preparations, is associated with neuropsychological deficits in children...
  41. ncbi [Are cialit-preserved ossicles as middle ear implants still bacteriologically defensible? Their replacement by pre-formed implants fashioned from teeth]
    K B Huttenbrink
    HNO Universitätsklinik Münster
    Laryngorhinootologie 69:327-32. 1990
    ..The preformed prostheses can be autoclaved without problem. More than 150 reconstructions have proved the acceptance of this cheap implant material. Furthermore, forensic problems with ossicles from corpses do not arise...
  42. ncbi Mechanisms of mercury disposition in the body
    Thomas W Clarkson
    Department of Environmental Medicine, Rochester School of Medicine, Rochester, New York, USA
    Am J Ind Med 50:757-64. 2007
    ..The implications of these mechanisms with regard to biological monitoring are discussed...
  43. ncbi Time of perinatal immunization, thimerosal exposure and neurodevelopment at 6 months in breastfed infants
    Rejane C Marques
    Fundação Universidade Federal de Rondônia, Porto Velho, RO, Brasil
    Acta Paediatr 96:864-8. 2007
    ..We compared neurodevelopment (ND) in infants born in a state hospital (immunized within 24 h) and in privately run hospitals (immunized 2-4 days postnatally)...
  44. ncbi [Acute generalized exanthematous pustulosis in a child and epicutaneous tests with mercurials]
    T Bolzinger
    Service de Dermatologie, Hôpital Pellegrin Enfants, Bordeaux
    Ann Dermatol Venereol 120:223-5. 1993
    ..Mercury and its derivatives should be limited as much as possible in medicine and cosmetology...
  45. ncbi Ocular sensitivity to thimerosal: a problem with hepatitis B vaccine?
    L R Kirkland
    Department of Medicine, Emory University Hospital, Atlanta, GA 30322
    South Med J 83:497-9. 1990
    ..If others administering the vaccine would ask the proper questions, sufficient numbers could be generated and reported that would either support the contraindication, or lead to a change in its present wording...
  46. ncbi The history of vaccinations in the light of the autism epidemic
    Stephanie F Cave
    Cypress Integrative Medicine, Baton Rouge, Louisiana, USA
    Altern Ther Health Med 14:54-7. 2008
    ..The impact that the Poling case will have on the ability of parents of autistic children to gain access to funds to enable them to properly care for their children remains to be seen...
  47. ncbi Isotopic fractionation of mercury induced by reduction and ethylation
    Lu Yang
    Institute for National Measurement Standards, National Research Council Canada, Ottawa, ON, K1A 0R6, Canada
    Anal Bioanal Chem 393:377-85. 2009
    ..Mass-dependent fractionation was found to be dominant for all reduction processes...
  48. ncbi Degradation of methyl and ethyl mercury into inorganic mercury by other reactive oxygen species besides hydroxyl radical
    I Suda
    Department of Pharmacology, Kumamoto University Medical School, Japan
    Arch Toxicol 66:34-9. 1992
    ..These results suggested that HOCl (or HOI) might be also capable of degrading MeHg and EtHg, besides the hydroxyl radical already reported by us. Singlet oxygen could degrade EtHg but not MeHg...
  49. ncbi [Lack of association between thimerosal-containing vaccines and autism]
    Dorota Mrozek-Budzyn
    Katedra Epidemiologii i Medycyny Zapobiegawczej, Uniwersytet Jagielloński Collegium Medicum, Krakow
    Przegl Epidemiol 65:491-5. 2011
    ..29-11.11) for doses 12.5-87.5 microg, 2.78 (95% CI: 0.29-11.11) for 100-137.5 microg and 1.97 (95% CI: 0.37-18.95) for these exposed > or = 150 microg. Our study revealed no evidence of an association between TCVs and autism...
  50. ncbi Solution cathode glow discharge induced vapor generation of mercury and its application to mercury speciation by high performance liquid chromatography-atomic fluorescence spectrometry
    Qian He
    State Key Laboratory of Biogeology and Environmental Geology, China University of Geosciences, Wuhan, China
    J Chromatogr A 1218:4462-7. 2011
    ..19 μg L(-1) for EtHg, respectively. The developed method was validated by determination of certified reference material (GBW 10029, tuna fish) and was further applied for the determination of mercury in biological samples...
  51. ncbi Speciation of methyl- and ethyl-mercury in hair of breastfed infants acutely exposed to thimerosal-containing vaccines
    Jose G Dorea
    Department of Environmental Sciences, Jozef Stefan Institute, Ljubljana, Slovenia
    Clin Chim Acta 412:1563-6. 2011
    ..The aim of the study is to evaluate a new analytical method for ethyl and methyl mercury in hair samples of breastfed infants who had received the recommended schedule of TCV...
  52. ncbi Degradation of methyl and ethyl mercury into inorganic mercury by various phagocytic cells
    I Suda
    Department of Pharmacology, Kumamoto University Medical School, Japan
    Arch Toxicol 66:40-4. 1992
    ..It was also suggested that the degradation of alkyl Hg by these cells might be an intraphagosomal event...
  53. ncbi Behavioral effects of prenatal methoxy-ethyl-mercury chloride exposure in rat pups
    K Lehotzky
    National Institute of Occupational Health, Budapest, Hungary
    Neurotoxicol Teratol 10:471-4. 1988
    ..Our results show a dose-dependent behavioral teratogenicity of this organomercurial fungicide. The so called no effect level--as far as the neurobehavioral impairments due to prenatal exposure are concerned--is 0.02 mg/kg daily...
  54. ncbi Degradation of methyl and ethyl mercury into inorganic mercury by hydroxyl radical produced from rat liver microsomes
    I Suda
    Department of Pharmacology, Kumamoto University Medical School, Japan
    Arch Toxicol 66:398-402. 1992
    ..Since both .OH and inorganic Hg production decreased with a concomitant decrease in NADPH-cytochrome P-450 reductase activities, it is suggested that this enzyme may be involved in the microsomal degradation of MeHg and EtHg...
  55. ncbi Determination of organic and inorganic mercury species in water and sediment samples by HPLC on-line coupled with ICP-MS
    José Soares dos Santos
    Departamento de Ciencias Naturais, Universidade Estadual do Sudoeste da Bahia, Vitória da Conquista, Bahia Zip 45083 900, Brazil
    Talanta 80:207-11. 2009
    ..The application of the proposed procedure to the determination of mercury species in drinking water sample was investigated. The proposed method clearly gave satisfactory average recoveries between 93.7 and 101.5%...
  56. ncbi Are neuropathological conditions relevant to ethylmercury exposure?
    Michael Aschner
    Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neurotox Res 18:59-68. 2010
    ..However, one cannot rule out the possibility that the individual gene profile and/or gene-environment interactions may play a role in modulating the response to acquired risk by modifying the individual susceptibility...
  57. ncbi Reactions to thimerosal in hepatitis B vaccines
    R L Rietschel
    Department of Dermatology, Ochsner Clinic, New Orleans, Louisiana
    Dermatol Clin 8:161-4. 1990
    ..Although not all thimerosal-sensitive patients develop adverse reactions to vaccines containing this material, there is a potential risk, and the reactions can be very long lasting...
  58. ncbi Kawasaki's disease, acrodynia, and mercury
    J Mutter
    Department of Environmental and Complementary Medicine, Salusmed Medical Center, Wieslistrasse 34, CH 8267 Berlingen, Switzerland
    Curr Med Chem 15:3000-10. 2008
    ..The presented pathogenetic model may lead to new preventive- and therapeutic strategies for Kawasaki's disease...
  59. ncbi Thimerosal is unrelated to autoimmune autism
    Vijendra K Singh
    Pediatr Allergy Immunol 18:89. 2007
  60. ncbi Of vaccine-autism, thimerosal, and metallothioneins
    Gianpaolo Guzzi
    Pediatr Allergy Immunol 18:88; author reply 89. 2007
  61. ncbi Crystallization of retinol dehydratase from Spodoptera frugiperda: improvement of crystal quality by modification by ethylmercurythiosalicylate
    S Pakhomova
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Acta Crystallogr D Biol Crystallogr 56:1641-3. 2000
    ..Crystals (space group P2(1), unit-cell parameters a = 82.05, b = 66.61, c = 84.90 A, beta = 111.29 degrees ) are significantly improved by covalent modification of the protein with ethylmercury...
  62. ncbi Route of decomposition of thiomersal (thimerosal)
    M Tan
    School of Pharmacy, Curtin University of Technology, G P O Box U 1987, WA 6845, Perth, Australia
    Int J Pharm 208:23-34. 2000
    ..In the presence of copper ions 2-sulfobenzoic acid was also formed. A mechanism has been proposed which accounts for the stoichiometry of the cleavage reaction observed and the significance of the reaction is discussed...
  63. ncbi Hyposensitizing therapy with standard antigenic extracts: an important source of thimerosal sensitization
    A Tosti
    Department of Dermatology, University of Bologna, Italy
    Contact Dermatitis 20:173-6. 1989
    ....
  64. ncbi Determination of methyl-, ethyl-, phenyl and total mercury in Neckar River fish
    R Falter
    Institut für Sedimentforschung, Heidelberg, Germany
    Chemosphere 29:1333-8. 1994
    ..It was found that at least 83% of total mercury is present as methyl mercury. Only a barbel exceeded the German maximum acceptable residue limit (500 micrograms/kg) with 812 micrograms/kg total mercury...
  65. ncbi [The effect of the duration of methoxyethylmercury acetate exposure on the lymphocytes in the peripheral blood of carp (Cyprinus carpio L.)]
    B Zidar
    Anstalt für Pathophysiologie, Veterinärmedizinischen Fakultät Zagreb Kroatien
    Dtsch Tierarztl Wochenschr 101:444-6. 1994
    ..The population of large lymphocytes showed the cytopathological changes in the form of cytoplasmic vacuoles and cytoplasmic shoots. The frequency of these changes increased through the experiments...
  66. ncbi Potentiating effects of organomercuries on clastogen-induced chromosome aberrations in cultured Chinese hamster cells
    H Yamada
    Faculty of Pharmaceutical Science, Toyama Medical and Pharmaceutical University, Japan
    Mutat Res 290:281-91. 1993
    ....
  67. ncbi The use of sodium sulfide to separate mercury from tissues preserved in Cialit and Merthiolate solutions
    R Jakse
    ENT Clinic, University of Graz, Austria
    Arch Otorhinolaryngol 244:259-61. 1987
    ..Further, the extraction of Hg is quicker in sodium sulfide than in an isotonic solution of sodium chloride...
  68. ncbi Thimerosal: a hidden allergen in ophthalmology
    A Tosti
    Department of Dermatology, University of Bologna, Italy
    Contact Dermatitis 18:268-73. 1988
    ..All 36 patients showed a positive patch test reaction to thimerosal, while only 1 of them reacted to an ophthalmic solution. Thimerosal sensitization appears to be clinically relevant in ophthalmic patients...
  69. ncbi Thiomersal allergy and vaccination reactions
    N H Cox
    Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, UK
    Contact Dermatitis 18:229-33. 1988
    ..However, individual cases of severe reactions to thiomersal demonstrate a need for vaccines with an alternative preservative...
  70. ncbi Thimerosal: an ophthalmic preservative which acts as a hapten to elicit specific antibodies and cell mediated immunity
    F Cai
    Dept Microbiol and Immunol, McGill University, Montreal, Quebec, Canada
    Curr Eye Res 7:341-51. 1988
    ..Therefore, the epitopes produced by these two reaction mechanisms were probably immunochemically different even though both contained detectable thimerosal derived mercury...
  71. ncbi Thimerosal, an inhibitor of endothelial acyl-coenzyme A: lysolecithin acyltransferase, stimulates the production of a nonprostanoid endothelium-derived vascular relaxing factor
    U Forstermann
    Department of Clinical Pharmacology, Hannover Medical School, Federal Republic of Germany
    Adv Prostaglandin Thromboxane Leukot Res 17:1108-11. 1987
    ..The above results suggest that inhibition of acyl-CoA:lysophosphatide acyltransferase (by interaction with thiol groups of the enzyme) is the mechanism underlying the thimerosal-induced EDRF production...
  72. ncbi [Individual sensitivity of cilia. A simple in vitro test method]
    A Wichelhaus
    Univ Hals Nasen Ohrenklinik Heidelberg
    Laryngol Rhinol Otol (Stuttg) 67:523-5. 1988
    ..This is illustrated by the example of two preservatives introduced in human medicine: chlorhexidine and merthiolate...
  73. ncbi Enhancement of eicosanoid synthesis in mouse peritoneal macrophages by the organic mercury compound thimerosal
    V Kaever
    Department of Pharmacology and Toxicology, Medical School Hannover, FRG
    Prostaglandins 35:885-902. 1988
    ..Thimerosal therefore provides a helpful tool in studying the basic regulatory mechanisms of the cellular leukotriene synthesis...
  74. ncbi Cialit preserved cartilage: failure to guarantee sterility
    W A Dickson
    Department of Plastic Surgery, St Luke s Hospital, Bradford
    Br J Plast Surg 41:408-9. 1988
    ..Cialit solution has no virucidal activity, and the risk of viral infections such as AIDS and hepatitis is a further reason not to use it as a storage solution for cartilage...
  75. ncbi [Bibliographical study of Minamata disease]
    Nobuo Ishihara
    Research Centre for Occupational Disease, Tohoku Rosai Hospital, 4 3 21 Dainohara, Sendai 981 0911, Japan
    Nihon Eiseigaku Zasshi 56:649-54. 2002
    ..If these reports had been referred to at the outbreak of Minamata Disease, the number of victims in Minamata would have been minimized, and Minamata Disease in Niigata would have been prevented...
  76. ncbi [Allergy to mercurothiolate in an infant during heparinization of an intracaval catheter]
    P Chastagner
    Service de Médecine infantile 3, CHRU de Brabois, Vandoevre
    Presse Med 17:795-6. 1988
    ..This conservative agent is present in numerous pharmaceutical preparations for topical and systemic use...
  77. ncbi Comparison of organic and inorganic mercury distribution in suckling rat
    Tatjana Orct
    Mineral Metabolism Unit, Institute for Medical Research and Occupational Health, Zagreb, Croatia
    J Appl Toxicol 26:536-9. 2006
    ..However, the brain and blood concentrations of mercury were higher in the thiomersal exposed group. These results need to be clarified by additional data on the kinetic pathways of ethylmercury compared with inorganic mercury...
  78. ncbi Effect of thimerosal in leukemia, in leukemic cell lines, and on normal hematopoiesis
    T J Panella
    Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710
    Cancer Res 50:4429-35. 1990
    ..The differentiation effect of thimerosal is blocked by a sulfhydryl-protective agent, dithiothreitol, suggesting that the mechanism of differentiation may be mediated via a sulfhydryl group-dependent process...
  79. ncbi Factors that influence methylmercury flux rates from wetland sediments
    Jonathan Holmes
    Biology Department, University of Ottawa, Ottawa, ON, Canada
    Sci Total Environ 368:306-19. 2006
    ..EtHg levels in sediment exceeded MeHg concentrations in two of the wetlands. This demonstrates that Hg ethylation is a significant part of the Hg cycle in some aquatic environments...
  80. ncbi When science is not enough - a risk/benefit profile of thiomersal-containing vaccines
    C John Clements
    Centre for International Health, The Macfarlane Burnet Institute for Medical Research and Public Health Ltd, GPO Box 2284, Commercial Road, Melbourne, VIC 3004, Australia
    Expert Opin Drug Saf 5:17-29. 2006
    ....
  81. ncbi In vitro uptake of glutamate in GLAST- and GLT-1-transfected mutant CHO-K1 cells is inhibited by the ethylmercury-containing preservative thimerosal
    Lysette Mutkus
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Biol Trace Elem Res 105:71-86. 2005
    ..These studies suggest that thimerosal accumulation in the central nervous system might contribute to dysregulation of glutamate homeostasis...
  82. ncbi Increased ethyl mercury load in protein a immunoadsorption
    Andreja Marn-Pernat
    University Medical Center Ljubljana, Department of Nephrology, University of Ljubljana, Ljubljana, Slovenia
    Ther Apher Dial 9:254-7. 2005
    ....
  83. ncbi Simultaneous determination of methylmercury and ethylmercury in rice by capillary gas chromatography coupled on-line with atomic fluorescence spectrometry
    Jian Bo Shi
    Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, Beijing, 100085, People s Republic of China
    J AOAC Int 88:665-9. 2005
    ..In all samples, MeHg was detectable and no EtHg was found. The MeHg contents in rice samples ranged from 1.9 to 10.5 ng/g, accounting for 7-44% of the total mercury measured...
  84. ncbi Solid-phase extraction-gas chromatography-mass spectrometry using a fullerene sorbent for the determination of inorganic mercury(II), methylmercury(I) and ethylmercury(I) in surface waters at sub-ng/ml levels
    J Munoz
    Department of Analytical Chemistry, University of Cordoba, Annex C 3 Building, Campus of Rabanales, E 14071 Cordoba, Spain
    J Chromatogr A 1055:185-90. 2004
    ..The method was used for the speciation of inorganic mercury, methylmercury and ethylmercury in various types of water including sea and waste water...
  85. ncbi The sulfhydryl reagent thimerosal elicits human platelet aggregation by mobilization of intracellular calcium and secondary prostaglandin endoperoxide formation
    M Hecker
    Faculty of Biology, University of Konstanz, Federal Republic of Germany
    Biochem Biophys Res Commun 159:961-8. 1989
    ....
  86. ncbi The evidence for the safety of thiomersal in newborn and infant vaccines
    C John Clements
    Centre for International Health, The Macfarlane Burnet Institute for Medical Research and Public Health Ltd, GPO Box 2284, Commercial Road, Melbourne, VIC 3004, Australia
    Vaccine 22:1854-61. 2004
    ..Given the same levels of exposure, adults are at much lower levels of risk because of increased body mass. It is not possible to prove that thiomersal is completely safe-epidemiology can only quantify a risk, not prove its absence...
  87. ncbi Determination of methylmercury, ethylmercury, and inorganic mercury in mouse tissues, following administration of thimerosal, by species-specific isotope dilution GC-inductively coupled plasma-MS
    Johanna Qvarnström
    Analytical Chemistry, Department of Chemistry, Umea University, S 901 87 Umea, Sweden
    Anal Chem 75:4120-4. 2003
    ..This shows that C2H5Hg+ in mice to a large degree is degraded to Hg2+. Increased concentrations of CH3Hg+ were also observed, which was found to be due to impurities in the thimerosal...
  88. ncbi Association between thimerosal-containing vaccine and autism
    Anders Hviid
    Danish Epidemiology Science Centre, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    JAMA 290:1763-6. 2003
    ..Thus it has been suggested that childhood vaccination with thimerosal-containing vaccine could be causally related to neurodevelopmental disorders such as autism...
  89. ncbi [The design and evaluation of horizontal pipe mini-flame atomization and ionization synchronous detector in GC/AAS]
    Z Yan
    Department of Chemistry, Hebei University, Baoding 071002, China
    Se Pu 19:32-6. 2001
    ..The optimum performance of the atomization and ionization can be quickly adjusted by changing the flow rates of the corresponding gases such as H2, N2 and air...
  90. ncbi Preparation of heavy-atom derivatives using site-directed mutagenesis. Introduction of cysteine residues into gamma delta resolvase
    G F Hatfull
    Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, New Haven, CT 06511
    J Mol Biol 208:661-7. 1989
    ..Two mutant proteins provided excellent heavy-atom derivatives. This approach should be of general use and particularly helpful in cases where traditional methods have failed to produce a derivative...
  91. ncbi Neurotoxic character of thimerosal and the allometric extrapolation of adult clearance half-time to infants
    L Magos
    J Appl Toxicol 23:263-9. 2003
    ..Blood mercury concentrations observed after vaccination showed agreement with allometrically extrapolated concentrations...
  92. ncbi Effect of organic and inorganic mercuric salts on Na+K+ATPase in different cerebral fractions in control and intrauterine growth-retarded rats: alterations induced by serotonin
    C Chanez
    Unité 26, INSERM, Hopital Fernand Widal, Paris, France
    Neurotoxicology 10:699-706. 1989
    ..In the synaptosomal fraction reverse effect was noted with serotonin. In myelin fraction, added serotonin increased inhibition caused by thimerosal...
  93. ncbi Simultaneous determination of methyl- and ethyl-mercury by solid-phase microextraction followed by gas chromatography atomic fluorescence detection
    Luis Carrasco
    Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, IDAEA CSIC, Jordi Girona, 18 26, E 08034 Barcelona, Spain
    J Chromatogr A 1216:8828-34. 2009
    ..13 ng g(-1) for both, MeHg and EtHg. The developed analytical procedure was validated with a certified reference material (DORM-2) and applied to the determination of organomercury incurred in waterfowl egg and fish samples...
  94. ncbi Degradation of methyl and ethyl mercury by singlet oxygen generated from sea water exposed to sunlight or ultraviolet light
    I Suda
    Kyushu National Agricultural Experiment Station, MAFF, Kumamoto, Japan
    Arch Toxicol 67:365-8. 1993
    ..These results suggested that 1O2 generated from sea water exposed to sunlight, UV light A or UV light B was the reactive oxygen species mainly responsible for the degradation of MeHg and EtHg...
  95. ncbi Speciation of mercury by ionic liquid-based single-drop microextraction combined with high-performance liquid chromatography-photodiode array detection
    Francisco Pena-Pereira
    Departamento de Quimica Analitica y Alimentaria, Area de Quimica Analitica, Facultad de Quimica, Universidad de Vigo, Campus As Lagoas Marcosende s n, 36310 Vigo, Spain
    Talanta 78:537-41. 2009
    ..7 and 11.6% (n=8). The method was finally applied to the determination of mercury species in different water samples...
  96. ncbi 'Cialit' as a tissue preservative: a microbiological assessment
    B D Cookson
    Dept of Microbiology, United Medical School of Guys Hospital, London, UK
    J Hosp Infect 11:263-70. 1988
    ..Our results emphasize the importance of adequate tissue bank microbiological screening. Alternative methods of tissue preservation should be considered...

Research Grants1

  1. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ....