organometallic compounds

Summary

Summary: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow
    Paula Urquhart
    William Harvey Research Institute, London, UK
    J Pharmacol Exp Ther 321:656-62. 2007
  2. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
  3. pmc T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA
    Nadine Kawel
    Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1074, USA
    J Cardiovasc Magn Reson 14:26. 2012
  4. ncbi Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
    Peter Caravan
    EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
    Chem Soc Rev 35:512-23. 2006
  5. ncbi Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
    Edith Bonnelye
    Laboratoire de Génomique Fonctionelle de Lyon, Université de Lyon UMR5242, CNRS INRA ENS Université Lyon1 IFR 128 Biosciences Lyon Gerland, 46, Allee d Italie, 69007 Lyon, France
    Bone 42:129-38. 2008
  6. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
  7. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
  8. ncbi Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
  9. ncbi CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    FASEB J 19:284-6. 2005
  10. ncbi Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate
    Roelf Valkema
    Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 46:83S-91S. 2005

Detail Information

Publications361 found, 100 shown here

  1. ncbi Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow
    Paula Urquhart
    William Harvey Research Institute, London, UK
    J Pharmacol Exp Ther 321:656-62. 2007
    ..In conclusion, we have reported that CORM-3 possesses acute anti-inflammatory effects in vivo and that these are probably the result of targeting PMN activation and rolling upon the endothelium...
  2. ncbi The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunction
    R J Kim
    Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
    N Engl J Med 343:1445-53. 2000
    ..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
  3. pmc T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA
    Nadine Kawel
    Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1074, USA
    J Cardiovasc Magn Reson 14:26. 2012
    ..The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents...
  4. ncbi Strategies for increasing the sensitivity of gadolinium based MRI contrast agents
    Peter Caravan
    EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
    Chem Soc Rev 35:512-23. 2006
    ..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging...
  5. ncbi Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro
    Edith Bonnelye
    Laboratoire de Génomique Fonctionelle de Lyon, Université de Lyon UMR5242, CNRS INRA ENS Université Lyon1 IFR 128 Biosciences Lyon Gerland, 46, Allee d Italie, 69007 Lyon, France
    Bone 42:129-38. 2008
    ..It stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization...
  6. pmc T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial region
    Nadine Kawel
    Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
    J Cardiovasc Magn Reson 14:27. 2012
    ..The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region...
  7. pmc Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolus
    Erik B Schelbert
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 13:16. 2011
    ..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
  8. ncbi Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
    ..In the long term, transition metal carbonyls could be utilized for the therapeutic delivery of CO to alleviate vascular- and immuno-related dysfunctions. The full text of this article is available at http://www.circresaha.org...
  9. ncbi CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    FASEB J 19:284-6. 2005
    ....
  10. ncbi Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotate
    Roelf Valkema
    Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 46:83S-91S. 2005
    ....
  11. pmc Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    Philip Sawle
    Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 145:800-10. 2005
    ....
  12. pmc Characterization of positron emission tomography hypoxia tracer uptake and tissue oxygenation via electrochemical modeling
    Stephen R Bowen
    University of Wisconsin School of Medicine and Public Health, Department of Medical Physics, Madison, WI 53706, USA
    Nucl Med Biol 38:771-80. 2011
    ..Differences in imaged uptake of two common hypoxia radiotracers, [(61)Cu]Cu-ATSM and [(18)F]FMISO, were characterized via computational modeling to address these challenges...
  13. ncbi Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot study
    David W Dietz
    Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Dis Colon Rectum 51:1641-8. 2008
    ....
  14. pmc Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339
    Petra Heffeter
    Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Austria
    J Biol Inorg Chem 15:737-48. 2010
    ..The different protein binding patterns as compared with those for cisplatin suggest specific protein targets and consequently a unique mode of action for the ruthenium drugs investigated...
  15. ncbi From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)
    Christian G Hartinger
    Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
    J Inorg Biochem 100:891-904. 2006
    ..In this review, the preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated...
  16. ncbi Ruthenium antimetastatic agents
    Enzo Alessio
    Department of Chemical Sciences, University of Trieste, Via L Giorgieri 1, 34127 Trieste, Italy
    Curr Top Med Chem 4:1525-35. 2004
    ..All active NAMI-A-type compounds share the capacity to modify important parameters of metastasis such as tumor invasion, matrix metallo proteinases activity and cell cycle progression...
  17. ncbi A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agent
    Jeany M Rademaker-Lakhai
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Clin Cancer Res 10:3717-27. 2004
    ..Furthermore, the ruthenium pharmacokinetics (PK) after NAMI-A administration and preliminary antitumor activity were evaluated...
  18. ncbi Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot study
    Yumiko Minagawa
    Department of Radiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
    Ann Nucl Med 25:339-45. 2011
    ..We undertook a pilot study in patients with locally advanced head and neck cancer to determine whether there is a relationship between tumor uptake of (62)Cu-ATSM and response to chemoradiotherapy...
  19. ncbi Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle
    Camille Taillé
    INSERM Unité 700 and Unité 683, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Biol Chem 280:25350-60. 2005
    ..This study provides a new mechanism to explain redox signaling by CO...
  20. ncbi Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applications
    Peter Reimer
    Department of Radiology, Stadtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Moltkestrasse 90, 76133 Karlsruhe, Germany
    Eur Radiol 14:559-78. 2004
    ..No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other...
  21. ncbi Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytes
    Shalini Roy
    Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
    Food Chem Toxicol 49:2564-74. 2011
    ..We conclude that DPDT and TeCl(4) are cytotoxic to astrocytes. TeCl(4) treated cells die via the intrinsic apoptotic pathway. Accumulation of tellurium occurs with both compounds, but results in different mechanisms of cell death...
  22. pmc Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiography
    Timothy C Wong
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Cardiovasc Magn Reson 15:6. 2013
    ..We assessed whether CMR improves outcomes prediction after contemporaneous echo, which may have implications for efforts to optimize processes of care, assess effectiveness, and allocate limited health care resources...
  23. pmc A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 334:639-42. 2011
    ..Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging...
  24. ncbi Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators
    Kelly S Davidge
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Ct, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 284:4516-24. 2009
    ..Our discovery that CORM-3 is an effective inhibitor and global regulator of gene expression, especially under aerobic conditions, has important implications for administration of CO-releasing agents in sepsis and inflammation...
  25. ncbi Immunomodulating tellurium compounds as anti-cancer agents
    Benjamin Sredni
    The Safdié Institute for AIDS and Immunology Research, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
    Semin Cancer Biol 22:60-9. 2012
    ..These properties, coupled with the excellent safety profile of the compounds, suggest promising anti-cancer therapeutic potential for tellurium compounds such as AS101 or SAS...
  26. ncbi Soft porous crystals
    Satoshi Horike
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto 615 8510, Japan
    Nat Chem 1:695-704. 2009
    ..We discuss the relationship between the structures and properties of these materials in view of their practical applications...
  27. ncbi Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2
    Christian Ingo Schwer
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Hugstetterstrasse 55, D 79106 Freiburg, Germany
    Int J Biochem Cell Biol 45:201-12. 2013
    ..However, prolonged exogenous application of CO might also have negative effects on cellular protein homeostasis...
  28. ncbi Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposure
    Bruna Comparsi
    Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Mol Cell Biochem 370:173-82. 2012
    ..In particular the inhibition of important selenoenzymes (TrxR and GPx) seems to be involved in the neurotoxicity associated with (PhTe)(2) exposure in adult mice...
  29. ncbi Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinoma
    Yukie Yoshii
    Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui 910 1193, Japan
    Nucl Med Biol 38:151-7. 2011
    ..In this study, we evaluated the therapeutic effect of (64)Cu-ATSM in relation to CD133 expression using this model...
  30. ncbi Live cell luminescence imaging as a function of delivery mechanism
    Xiaohe Tian
    Department of Biomedical Science, The University of Sheffield, Sheffield S10 7TN, UK
    Chembiochem 12:548-51. 2011
    ..This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties...
  31. ncbi Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modes
    Hakan Niyazi
    Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK
    Nat Chem 4:621-8. 2012
    ..The TA/TA specificity of the perpendicular intercalation arises from the packing of phenanthroline ligands against the adenosine residue...
  32. ncbi p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitro
    Nils Schallner
    Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
    Eur J Pharmacol 670:58-66. 2011
    ..Furthermore, the p38β isoform activation may represent an upstream mechanism of heat shock response induction...
  33. ncbi Nephrogenic systemic fibrosis: risk factors and incidence estimation
    Elizabeth A Sadowski
    Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
    Radiology 243:148-57. 2007
    ..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...
  34. pmc Treatment of Mediterranean visceral leishmaniasis
    L Gradoni
    Laboratorio di Parassitologia, , Rome, Italy
    Bull World Health Organ 73:191-7. 1995
    ....
  35. ncbi Energy metabolism transition in multi-cellular human tumor spheroids
    Sara Rodriguez-Enriquez
    Departamento de Bioquimica, Instituto Nacional de Cardiologia, Mexico, Mexico
    J Cell Physiol 216:189-97. 2008
    ..These results suggest that glycolysis and OxPhos might be considered as metabolic targets to diminish cellular proliferation in poorly vascularized, hypoxic solid tumors...
  36. ncbi Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agents
    Sophie Laurent
    Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, 24 Avenue du Champ de Mars, B 7000 Mons, Belgium
    Contrast Media Mol Imaging 1:128-37. 2006
    ..As a result, the relaxivity of MultiHance in HSA-containing media of fixed concentration decreases with increasing concentration of the contrast agent...
  37. ncbi A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cells
    Martin R Gill
    Department of Chemistry, University of Sheffield, Sheffield, UK
    Nat Chem 1:662-7. 2009
    ....
  38. ncbi Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts
    Steeve Kwan Tat
    Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada
    Bone 49:559-67. 2011
    ..In this study, we investigated in human OA subchondral bone osteoblasts the modulatory effect of strontium ranelate on the above key factors...
  39. ncbi Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice
    Gediminas Cepinskas
    Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, N6A 4G4, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G184-91. 2008
    ....
  40. ncbi Interaction of [Ru(bpy)2(dppz)]2+ with human telomeric DNA: preferential binding to G-quadruplexes over i-motif
    Shuo Shi
    Department of Chemistry, Tongji University, Shanghai, PR China
    Biochimie 92:370-7. 2010
    ..The results also indicated that [Ru(bpy)(2)(dppz)](2+) could serve as a prominent molecular "light switch" for both G-quadruplexes, revealing a potential application of the title complex in luminescent signaling of G-quadruplex DNA...
  41. ncbi Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophages
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine and Institute of Life Sciences, Gyeongsang National University, Jinju, Gyeongsang, Korea
    Shock 34:608-14. 2010
    ....
  42. ncbi A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE Study
    Peter H Katelaris
    Department of Gastroenterology, Concord Hospital, University of Sydney, West, Australia
    Gastroenterology 123:1763-9. 2002
    ..Direct comparisons of bismuth and proton pump inhibitor (PPI)-based triple and quadruple therapies for Helicobacter pylori eradication are lacking. To address this, a randomized study was conducted...
  43. ncbi Evaluation of unusual neuroendocrine tumours by means of 68Ga-DOTA-NOC PET
    Stefano Fanti
    Unità Operativa di Medicina Nucleare, Policlinico S Orsola Malpighi, Bologna, Italy
    Biomed Pharmacother 62:667-71. 2008
    ..On the other hand, care has to be paid when studying lesions localized at sites of physiological concentration of the tracer, and in presence of inflammation...
  44. pmc Regional convection-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivo
    Garrett W Astary
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States
    J Neurosci Methods 187:129-37. 2010
    ..Therefore, CED, combined with high-resolution MR imaging, may be a useful strategy for delivering therapeutics for the treatment of CNS disorders affecting the hippocampus...
  45. ncbi Strontium ranelate does not stimulate bone formation in ovariectomized rats
    R K Fuchs
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
    Osteoporos Int 19:1331-41. 2008
    ..We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium...
  46. ncbi Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonance
    Andrew S Flett
    Department of Cardiology, The Heart Hospital, University College London Hospitals NHS Trust, London, UK
    JACC Cardiovasc Imaging 4:150-6. 2011
    ....
  47. ncbi Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment
    Paul Roschger
    Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, 1140 Vienna, Austria
    J Bone Miner Res 25:891-900. 2010
    ..Taken together, these data provide evidence that the investigated bone quality determinants at tissue level were preserved in postmenopausal osteoporotic women after 3-year treatment with 2 g SrR per day plus calcium and vitamin D...
  48. ncbi Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis
    Emma D Deeks
    Adis, Auckland, New Zealand
    Drugs 70:733-59. 2010
    ..Overall, the clinical data available suggest that strontium ranelate is an effective and generally well tolerated option for the first-line treatment of postmenopausal osteoporosis...
  49. ncbi A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemia
    Mathieu Desmard
    INSERM U700, Faculte de Medecine, Universite Paris 7, Paris, France
    FASEB J 23:1023-31. 2009
    ..aeruginosa bacteremia. Our results suggest that CORMs could form the basis for developing a new therapeutic strategy against P. aeruginosa-induced infection...
  50. ncbi The interaction of MS-325 with human serum albumin and its effect on proton relaxation rates
    Peter Caravan
    EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
    J Am Chem Soc 124:3152-62. 2002
    ..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)...
  51. ncbi The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis model
    Nuria Maicas
    Department of Pharmacology, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjasot, Valencia, Spain
    Eur J Pharmacol 634:184-91. 2010
    ..Pharmacological CO delivery represents a novel strategy to regulate the effector phase of arthritis...
  52. ncbi Strontium ranelate promotes osteoblastic cell replication through at least two different mechanisms
    Joseph Caverzasio
    Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
    Bone 42:1131-6. 2008
    ....
  53. pmc Bone marrow dosimetry in peptide receptor radionuclide therapy with [177Lu-DOTA(0),Tyr(3)]octreotate
    Flavio Forrer
    Department of Nuclear Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 40, NL 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:1138-46. 2009
    ..Also, we evaluated the absorbed cross-dose from the source organs (liver, spleen, kidneys and blood), tumours and the so-called "remainder of the body" to the bone marrow...
  54. ncbi Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells
    Christiano M V Barbosa
    Centro Interdisciplinar de Investigação Bioquímica, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil
    Eur J Pharmacol 542:37-47. 2006
    ..Taken together, these data suggest a novel lysosomal pathway for BPC-induced apoptosis, in which lysosomes are the primary target and cathepsin B acts as death mediator...
  55. ncbi The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis
    Pierre J Meunier
    Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
    N Engl J Med 350:459-68. 2004
    ....
  56. ncbi Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival
    Dik J Kwekkeboom
    Department of Nuclear Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Oncol 26:2124-30. 2008
    ..Here we report on the toxicity and efficacy of this treatment, performed in over 500 patients...
  57. ncbi Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathione
    Claúdio dos Santos Ferreira
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
    Biometals 16:441-6. 2003
    ..In conclusion, our data supports the hypothesis that Sb(V) is reduced in vivo by T(SH)2 within Leishmania parasites and by Cys or Cys-Gly within the acidic compartments of mammalian cells...
  58. ncbi Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatment
    M Gramiccia
    Laboratorio di Parassitologia, , Rome, Italy
    Ann Trop Med Parasitol 86:613-20. 1992
    ..This result underlines the futility and danger of repeated antimonial treatments of dogs with signs of leishmaniasis, as these may produce a permanent reservoir of parasites unsusceptible to the drugs in human clinical use...
  59. pmc Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC
    Bingwei Sun
    Department of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, Jiangsu Province, PR China
    Int J Biol Sci 4:270-8. 2008
    ..To investigate the effects and potential mechanisms of preconditioning of tricarbonyldichlororuthenium (III) dimer (CORM-2)-liberated CO on LPS-induced activation of endothelial cells (HUVEC)...
  60. ncbi Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Nucl Med 49:201-5. 2008
    ..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
  61. ncbi Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength
    Patrick Ammann
    Division of Bone Diseases, WHO Collaborting Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland
    J Bone Miner Res 22:1419-25. 2007
    ....
  62. ncbi Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivo
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
    Mol Pharmacol 76:173-82. 2009
    ..Taken together, we concluded that HO-1-derived CO reduces HMGB1 release in LPS-activated cells and LPS- or CLP-induced animal model of sepsis...
  63. pmc Efficacy of miltefosine for the treatment of American cutaneous leishmaniasis
    Iván Vélez
    Universidad de Antioquia, Medellin, Colombia
    Am J Trop Med Hyg 83:351-6. 2010
    ....
  64. ncbi DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species
    Stephen Nesnow
    Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Chem Res Toxicol 15:1627-34. 2002
    ..These data are consistent with the conclusions that the DNA-damaging activity of DMA(III) is an indirect genotoxic effect mediated by ROS-formed concomitantly with the oxidation of DMA(III) to DMA(V)...
  65. ncbi Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
    ..The full text of this article is available online at http://www.circresaha.org...
  66. ncbi Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia species
    R Palacios
    Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
    Am J Trop Med Hyg 64:187-93. 2001
    ..Pathogenicity of infection and pharmacokinetics may affect the treatment response in children. New therapeutic alternatives should be evaluated in trials that include children and women...
  67. ncbi In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  68. pmc Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urine
    X C Le
    University of Alberta, Department of Public Health Sciences, Edmonton, Alberta, Canada
    Environ Health Perspect 108:1015-8. 2000
    ..Along with the presence of MMA(III), there was an increase in the relative concentration of MMA(V) and a decrease in DMA(V) in the urine samples collected after the DMPS ingestion...
  69. pmc Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics
    Ruolan Liu
    Neuroscience Program, University of Southern California, Los Angeles, CA 90090 2520, USA
    Proc Natl Acad Sci U S A 100:8526-31. 2003
    ..These results further support the role of reactive oxygen species in age-related learning impairment and suggest potential clinical applications for synthetic catalytic scavengers of reactive oxygen species...
  70. pmc Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule
    Roberta Foresti
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 142:453-60. 2004
    ....
  71. ncbi Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary tree
    Melanie K Seale
    Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
    Radiographics 29:1725-48. 2009
    ..In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function...
  72. pmc Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA(0),Tyr3]octreotate
    D J Kwekkeboom
    Department of Nuclear Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:417-22. 2003
    ..However, in view of the high success rate of therapy with (177)Lu-octreotate and the absence of serious side-effects, we advocate its use in patients with GEP tumours without waiting for tumour progression...
  73. ncbi A comparison of (111)In-DOTATOC and (111)In-DOTATATE: biodistribution and dosimetry in the same patients with metastatic neuroendocrine tumours
    F Forrer
    Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
    Eur J Nucl Med Mol Imaging 31:1257-62. 2004
    ....
  74. ncbi Comparison of [(177)Lu-DOTA(0),Tyr(3)]octreotate and [(177)Lu-DOTA(0),Tyr(3)]octreotide: which peptide is preferable for PRRT?
    J P Esser
    Department of Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 33:1346-51. 2006
    ..We compared in seven patients [(177)Lu-DOTA(0),Tyr(3)]octreotide ((177)Lu-DOTATOC) and [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE), to see which peptide should be preferred for PRRT with (177)Lu...
  75. ncbi Recent advances involving palladium (II) complexes for the cancer therapy
    Antonio Carlos Favero Caires
    Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes, Av Cândido Xavier de Almeida Souza, 200 CEP 08701 970, CP 411, Mogi das Cruzes SP, Brazil
    Anticancer Agents Med Chem 7:484-91. 2007
    ..New palladacycle compounds derived from N,N-dimethyl-1-phenethylamine and the ligand bis(diphenylphosphine)ferrocene were presented as effective antitumoral agents...
  76. ncbi Canine leishmaniasis: clinical, parasitological and entomological follow-up after chemotherapy
    J Alvar
    Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain
    Ann Trop Med Parasitol 88:371-8. 1994
    ..Some dogs from both the 'asymptomatic' and 'symptomatic' groups became infective to sandflies several months post-treatment...
  77. ncbi Metal-intercalated aromatic hydrocarbons: a new class of carbon-based superconductors
    Yoshihiro Kubozono
    Research Laboratory for Surface Science, Okayama University, Okayama, Japan
    Phys Chem Chem Phys 13:16476-93. 2011
    ..The features of other carbon-based superconductors are compared to clarify the nature of hydrocarbon superconductors...
  78. ncbi A synthetic model of the Mn₃Ca subsite of the oxygen-evolving complex in photosystem II
    Jacob S Kanady
    Department of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard MC 127 72, Pasadena, CA 91125, USA
    Science 333:733-6. 2011
    ....
  79. ncbi Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trial
    Cyrus Cooper
    MRC Lifecourse Epidemiology Unit, University of Southampton and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, UK
    Curr Med Res Opin 28:231-9. 2012
    ..We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis...
  80. ncbi Protective effect of naringenin against lead-induced oxidative stress in rats
    Jicang Wang
    College of Animal Science and Technology, Henan University of Science and Technology, No 70, Tianjin Road, 471003, Luoyang, People s Republic of China
    Biol Trace Elem Res 146:354-9. 2012
    ..05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats...
  81. ncbi Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PET
    Masamichi Ikawa
    Second Department of Internal Medicine Neurology, Faculty of Medical Sciences, University of Fukui, Eiheiji cho, Fukui 910 1193, Japan
    Nucl Med Biol 38:945-51. 2011
    ....
  82. pmc Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells
    Rajan Gogna
    Transcription and Human Biology Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
    Br J Pharmacol 166:617-36. 2012
    ..Understanding the mechanism of GaQ(3) -induced apoptosis will help establish this gallium-based organic compound as a potent anti-cancer drug...
  83. ncbi Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study
    J Y Reginster
    Department of Epidemiology, Public Health and Health Economics, University of Liege, CHU Centre Ville, 45 Quai Godefroid Kurth, 4020 Liege, Belgium
    J Clin Endocrinol Metab 90:2816-22. 2005
    ....
  84. pmc CMR assessment of endothelial damage and angiogenesis in porcine coronary arteries using gadofosveset
    Steen F Pedersen
    Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital Skejby, Aarhus N, Denmark
    J Cardiovasc Magn Reson 13:10. 2011
    ..We sought to examine whether contrast enhanced cardiovascular magnetic resonance (CMR) using gadofosveset could show endothelial damage and neovessel formation in balloon injured porcine coronary arteries...
  85. pmc En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]
    Gabriel E Büchel
    University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A 1090 Vienna, Austria
    Inorg Chem 50:7690-7. 2011
    ..Their antiproliferative acitivity in the human cancer cell lines CH1 (ovarian carcinoma), A549 (nonsmall cell lung carcinoma), and SW480 (colon carcinoma) is reported...
  86. ncbi Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [177Lu-DOTA0,Tyr3]octreotate
    Saima Khan
    Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 52:1361-8. 2011
    ..In this study, we investigated the QOL and symptoms after [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate) therapy in patients with inoperable or metastasized gastroenteropancreatic or bronchial neuroendocrine tumors (NETs)...
  87. ncbi Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysis
    Vasiliki Lykourinou
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA
    J Am Chem Soc 133:10382-5. 2011
    ....
  88. ncbi Peptide receptor radionuclide therapy with ¹⁷⁷Lu-DOTATATE: the IEO phase I-II study
    Lisa Bodei
    Division of Nuclear Medicine, European Institute of Oncology, Via Ripamonti, 435 20141 Milan, Italy
    Eur J Nucl Med Mol Imaging 38:2125-35. 2011
    ..The aim of this prospective phase I-II study was to evaluate the toxicity and efficacy of (177)Lu-DOTATATE in multiple cycles...
  89. pmc Partition coefficients for gadolinium chelates in the normal myocardium: comparison of gadopentetate dimeglumine and gadobenate dimeglumine
    Nadine Kawel
    Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    J Magn Reson Imaging 36:733-7. 2012
    ....
  90. ncbi Facile synthesis of pegylated zinc(II) phthalocyanines via transesterification and their in vitro photodynamic activities
    Ming Bai
    Department of Chemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Org Biomol Chem 9:7028-32. 2011
    ..3 to 79.8 nm depending on the preparation methods and conditions. The photocytotoxicity of these nanoparticles (IC(50) = 0.43-0.56 μM) was comparable with that of the Cremophor EL-formulated system (IC(50) = 0.34 μM)...
  91. ncbi Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trial
    Raymond J Kim
    Duke Cardiovascular MRI Center, DUMC 3934, Durham, NC 27710, USA
    Circulation 117:629-37. 2008
    ..We prospectively tested the performance of delayed-enhancement magnetic resonance imaging (MRI) with gadolinium-based contrast for the detection of MI in an international, multicenter trial...
  92. pmc Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse model
    Cynthia P W Soon
    Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
    J Biol Chem 286:44035-44. 2011
    ..CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS...
  93. ncbi Safety of gadobutrol, a new generation of contrast agents: experience from clinical trials and postmarketing surveillance
    Matthias Voth
    Bayer HealthCare Pharmaceutical, Schering Pharma AG, Global Medical Affairs Diagnostic Imaging, Berlin, Germany
    Invest Radiol 46:663-71. 2011
    ..To assess the clinical safety and tolerability of the macrocyclic contrast agent gadobutrol (Gadovist/Gadavist) overall and in specific patient populations based on clinical trials and postmarketing experience...
  94. pmc Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 134:17456-8. 2012
    ....
  95. ncbi Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexes
    C Andrew Boswell
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Med Chem 47:1465-74. 2004
    ..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
  96. ncbi Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trial
    Jean Yves Reginster
    University of Liege, Liege, Belgium
    Arthritis Rheum 58:1687-95. 2008
    ..This study was undertaken to assess the effect of strontium ranelate on nonvertebral and vertebral fractures in postmenopausal women with osteoporosis in a 5-year, double-blind, placebo-controlled trial...
  97. ncbi Peripheral magnetic resonance angiography with continuous table movement in combination with high spatial and temporal resolution time-resolved MRA With a total single dose (0.1 mmol/kg) of gadobutrol at 3.0 T
    Matthias Voth
    University Medical Center Mannheim, Institute of Clinical Radiology and Nuclear Medicine, University of Heidelberg, Mannheim, Germany
    Invest Radiol 44:627-33. 2009
    ..0 T with a single dose (0.1 mmol/kg) of gadobutrol in total...
  98. ncbi Contrast material for abdominal dynamic contrast-enhanced 3D MR angiography with parallel imaging: intraindividual equimolar comparison of a macrocyclic 1.0 M gadolinium chelate and a linear ionic 0.5 M gadolinium chelate
    Dariusch Reza Hadizadeh
    Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    AJR Am J Roentgenol 194:821-9. 2010
    ..0 M contrast agent with a linear ionic 0.5 M contrast agent at equimolar dosage in regard to image quality and number of vessel segments visualized at abdominal dynamic contrast-enhanced 3D MR angiography...
  99. ncbi Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosis
    Guadalupe Miró
    Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
    Vet Dermatol 20:397-404. 2009
    ..Miltefosine, in combination with allopurinol, offers a safe, convenient and effective alternative treatment option for canine leishmaniosis compared to the reference therapy...
  100. ncbi Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosis
    Marta Mateo
    Dpto Sanidad Animal, Universidad Complutense de Madrid, Spain
    Parasitol Res 105:155-62. 2009
    ....
  101. ncbi Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
    Patricia Horcajada
    Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
    Nat Mater 9:172-8. 2010
    ..In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments...

Research Grants51

  1. Titanium-gold-based chemotherapeutics for prostate and kidney cancer
    Maria Contel; Fiscal Year: 2013
    ..We will synthesize new titanium organometallic compounds with phosphine-, and iminophosphorane-modified cyclopentadienyl (Cp) ligands able to further coordinate ..
  2. Base-selective heavy atom labels for electron microscopy-based DNA sequencing
    F D Toste; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The proposed program aims to develop heavy atom organometallic compounds for ssDNA base-selective labeling for use in ultra-low-cost DNA sequencing technology based on single- ..
  3. Acquisition of a High Resolution TOF Mass Spectrometer
    Tadeusz F Molinski; Fiscal Year: 2010
    ..coupled with an HPLC for accurate mass determination of small molecules such as natural products, organometallic compounds, nucleic acids and non-polar organic synthetic intermediates that are generated in the research groups of ..
  4. RADIOPAQUE ADHESIVES AND DENTAL RESTORATIVE RESINS
    ISRAEL CABASSO; Fiscal Year: 2000
    ..This approach evolved to include organometallic compounds, monomers and polymers in which the metal is covalently bound to the organic structure...
  5. ENERGETICS AND DYNAMICS OF ORGANOMETALLIC REACTIONS
    GILBERT YANG; Fiscal Year: 1993
    The reactions of organometallic compounds play a central role in a great variety of important reactions...
  6. PURCHASE OF A MAGNETIC SECTOR MASS SPECTROMETER
    Joseph Marino; Fiscal Year: 2001
    ..The first purpose is obtaining full mass range, unit mass resolution spectra of organic and organometallic compounds in order to confirm identity and access purity...
  7. MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAM
    Harold Swartz; Fiscal Year: 1990
    ..Synthesis of DNA and RNA: 3. Synthetic methods and total synthesis of organic and organometallic compounds; 4. Conformational analysis of organic and organometallic compounds...
  8. ION TRAP AND DATA SYSTEM UPGRADE FOR MCMS
    Michael Gross; Fiscal Year: 1990
    ..service will be offered for local NIH-supported investigators, who need to prove structure of new organometallic compounds, and for at least ten NIH-funded researchers from outside the University of Nebraska...
  9. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  10. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  11. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..abstract_text> ..
  12. Mitochondrial control of neuronal excitotoxicity
    David Nicholls; Fiscal Year: 2005
    ..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
  13. Aging-Related Models and Mitochondrial Bioenergetics
    David Nicholls; Fiscal Year: 2006
    ..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
  14. HIGH-RISK NEUROBLASTOMA: A DEVASTATING CHILDHOOD CANCER
    Laurent Brard; Fiscal Year: 2008
    ..B3CD could potentially be used alone or in combination with standard chemotherapy to treat this devastating illness. ..
  15. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  16. Nicotine and Cognition in Parkinsonism
    Jay Schneider; Fiscal Year: 2008
    ..Information obtained from these studies will hopefully lead to more efficient design of nicotinic therapeutics for patients with a variety of cognitive disorders. ..
  17. CHEMICAL SENSORS FOR CELLULAR CONDITIONS AND COMPONENTS
    TIMOTHY GLASS; Fiscal Year: 2008
    ..Biological studies will be performed with the aid of collaborators in which cells will be stained with the fluorescent sensors and the location and concentration of neurotransmitter will be measured. ..
  18. GM1 Ganglioside Effects on Parkinson's Disease
    Jay Schneider; Fiscal Year: 2007
    ..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. [unreadable] [unreadable]..
  19. Center for Pediatric Stem/Progenitor Cell Translational Research
    Alice Tarantal; Fiscal Year: 2008
    ..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
  20. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
  21. ELECTRON-TRANSFER PROTEINS
    FRANCIS S contact MILLETT; Fiscal Year: 2010
    ..In the proposed studies, new ruthenium photoexcitation methods will be developed to study electron transfer reactions important to human health. ..
  22. Design of New Treatment Agents for Drug Abuse
    HUW M DAVIES; Fiscal Year: 2010
    ..This will be achieved through a multidisciplinary research program combining organic synthesis, medicinal chemistry, pharmacology and behavioral physiology, exploring the efficacy of a new class of 5HT2A receptor antagonists. ..
  23. CENTER FOR PROTEIN STRUCTURE AND FUNCTION
    Francis Millett; Fiscal Year: 2009
    ..abstract_text> ..
  24. Application of C-H Activation to Natural Product Synthesis
    HUW M DAVIES; Fiscal Year: 2010
    ....
  25. Controlled Catalytic Reduction of Dinitrogen at a Transition Metal Center
    Richard R Schrock; Fiscal Year: 2010
    ..abstract_text> ..
  26. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  27. Imaging Thymidine Uptake During Treatment for Head and Neck Cancer
    Yusuf Menda; Fiscal Year: 2008
    ..The studies proposed here will refine and characterize a non-invasive imaging test that may allow treatment responses to be determined shortly after treatment has begun. [unreadable] [unreadable] [unreadable]..
  28. Mesenchymal Stem Cells for Fetal Gene Delivery
    Alice Tarantal; Fiscal Year: 2006
    ..abstract_text> ..
  29. Calcium entry and vascular smooth muscle excitation
    KENNETH BYRON; Fiscal Year: 2006
    ..abstract_text> ..
  30. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  31. Conference on Photodynamic Therapy
    David Kessel; Fiscal Year: 2002
    ..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
  32. SYNTHESIS AND EVALUATION OF NOVEL COCAINE ANALOGS
    Huw Davies; Fiscal Year: 2002
    ..The proposed studies will ensure that a greater structural diversity is brought into the types of compounds that will be considered as potential medications for the treatment of cocaine addiction. ..
  33. SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLS
    KENNETH BYRON; Fiscal Year: 2002
    ..Finally, the effects of AVP and other hormones on [Ca2+]i and membrane currents will be examined in freshly isolated smooth muscle cells from rat mesenteric arteries. ..
  34. STRUCTURAL BASIS OF INSULIN MIMETIC EFFECT OF VANADYL
    MARVIN MAKINEN; Fiscal Year: 2003
    ..abstract_text> ..
  35. Promotion of PDT Induced phototoxicity by bile acids
    David Kessel; Fiscal Year: 2003
    ..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
  36. Pretargeting mouse tumor with anti-PSMA antibody-MORF
    Guozheng Liu; Fiscal Year: 2005
    ..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
  37. Attention in Children with the 22q11 Deletion Syndrome
    Christina Sobin; Fiscal Year: 2005
    ....
  38. Center for Fetal Gene Transfer for HLB Diseases
    Alice Tarantal; Fiscal Year: 2005
    ..abstract_text> ..
  39. Methylphenidate Analogs as Medications for Cocaine Abuse
    Huw Davies; Fiscal Year: 2006
    ..Initial studies will also be carried out to determine if useful PET radioligands can be made from any potent and selective analogs that are discovered during these studies. ..
  40. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  41. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  42. Cortical Catheters
    Martin Brady; Fiscal Year: 2004
    ..In Phase II or subsequent efforts, we will test the predictions of the models and simulations based on the hypotheses developed here, and evaluate the performance of SCD neurocatheters in an appropriate animal model. ..
  43. Proteomic determination of arsenical action
    Partha Basu; Fiscal Year: 2005
    ..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
  44. Effects of Dioxin on Vietnamese Civilians
    David Carpenter; Fiscal Year: 2004
    ..7. ..
  45. Phase II Trial of Thalidomide in Primary Amyloidosis
    Angela Dispenzieri; Fiscal Year: 2002
    ..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
  46. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  47. PET Imaging of Breast Cancer Using Oncogene Expression
    Mathew Thakur; Fiscal Year: 2008
    ..abstract_text> ..
  48. PET for Molecular Imaging of Small Animals
    Mathew Thakur; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  49. IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDE
    Mathew Thakur; Fiscal Year: 2002
    ..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..