Genomes and Genes
Summary: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Publications361 found, 100 shown here
- Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flowPaula Urquhart
William Harvey Research Institute, London, UK
J Pharmacol Exp Ther 321:656-62. 2007..In conclusion, we have reported that CORM-3 possesses acute anti-inflammatory effects in vivo and that these are probably the result of targeting PMN activation and rolling upon the endothelium...
- The use of contrast-enhanced magnetic resonance imaging to identify reversible myocardial dysfunctionR J Kim
Feinberg Cardiovascular Research Institute, and Department of Medicine, Northwestern University Medical School, Chicago, IL 60611 3008, USA
N Engl J Med 343:1445-53. 2000..We hypothesized that the results of contrast-enhanced MRI can be used to predict whether regions of abnormal ventricular contraction will improve after revascularization in patients with coronary artery disease...
- T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTANadine Kawel
Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892 1074, USA
J Cardiovasc Magn Reson 14:26. 2012..The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents...
- Strategies for increasing the sensitivity of gadolinium based MRI contrast agentsPeter Caravan
EPIX Pharmaceuticals, 67 Rogers St, Cambridge, MA 02142, USA
Chem Soc Rev 35:512-23. 2006..It may be of interest to senior undergraduates and more advanced researchers interested in lanthanide chemistry, biophysics, and/or molecular imaging...
- Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitroEdith Bonnelye
Laboratoire de Génomique Fonctionelle de Lyon, Université de Lyon UMR5242, CNRS INRA ENS Université Lyon1 IFR 128 Biosciences Lyon Gerland, 46, Allee d Italie, 69007 Lyon, France
Bone 42:129-38. 2008..It stimulates bone formation through its positive action on osteoblast differentiation and function, and decreases osteoclast differentiation as well as function by disrupting actin cytoskeleton organization...
- T1 mapping of the myocardium: intra-individual assessment of the effect of field strength, cardiac cycle and variation by myocardial regionNadine Kawel
Radiology and Imaging Sciences and Molecular Biomedical Imaging Laboratory, National Institute of Biomedical Imaging and Bioengineering, Bethesda, MD, USA
J Cardiovasc Magn Reson 14:27. 2012..The purpose of this study was to evaluate acquisition factors that may result in variation of measured T1 time and ECV including magnetic field strength, cardiac phase and myocardial region...
- Myocardial extravascular extracellular volume fraction measurement by gadolinium cardiovascular magnetic resonance in humans: slow infusion versus bolusErik B Schelbert
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Cardiovasc Magn Reson 13:16. 2011..Assuming equivalence between techniques, we further hypothesized that Ve measures would be reproducible across scans...
- Carbon monoxide-releasing molecules: characterization of biochemical and vascular activitiesRoberto Motterlini
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
Circ Res 90:E17-24. 2002..In the long term, transition metal carbonyls could be utilized for the therapeutic delivery of CO to alleviate vascular- and immuno-related dysfunctions. The full text of this article is available at http://www.circresaha.org...
- CORM-A1: a new pharmacologically active carbon monoxide-releasing moleculeRoberto Motterlini
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
FASEB J 19:284-6. 2005....
- Long-term follow-up of renal function after peptide receptor radiation therapy with (90)Y-DOTA(0),Tyr(3)-octreotide and (177)Lu-DOTA(0), Tyr(3)-octreotateRoelf Valkema
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Nucl Med 46:83S-91S. 2005....
- Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophagesPhilip Sawle
Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
Br J Pharmacol 145:800-10. 2005....
- Characterization of positron emission tomography hypoxia tracer uptake and tissue oxygenation via electrochemical modelingStephen R Bowen
University of Wisconsin School of Medicine and Public Health, Department of Medical Physics, Madison, WI 53706, USA
Nucl Med Biol 38:771-80. 2011..Differences in imaged uptake of two common hypoxia radiotracers, [(61)Cu]Cu-ATSM and [(18)F]FMISO, were characterized via computational modeling to address these challenges...
- Tumor hypoxia detected by positron emission tomography with 60Cu-ATSM as a predictor of response and survival in patients undergoing Neoadjuvant chemoradiotherapy for rectal carcinoma: a pilot studyDavid W Dietz
Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA
Dis Colon Rectum 51:1641-8. 2008....
- Intracellular protein binding patterns of the anticancer ruthenium drugs KP1019 and KP1339Petra Heffeter
Department of Medicine I, Institute of Cancer Research, Medical University Vienna, Austria
J Biol Inorg Chem 15:737-48. 2010..The different protein binding patterns as compared with those for cisplatin suggest specific protein targets and consequently a unique mode of action for the ruthenium drugs investigated...
- From bench to bedside--preclinical and early clinical development of the anticancer agent indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019 or FFC14A)Christian G Hartinger
Institute of Inorganic Chemistry, University of Vienna, Waehringer Strasse 42, A 1090 Vienna, Austria
J Inorg Biochem 100:891-904. 2006..In this review, the preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated...
- Ruthenium antimetastatic agentsEnzo Alessio
Department of Chemical Sciences, University of Trieste, Via L Giorgieri 1, 34127 Trieste, Italy
Curr Top Med Chem 4:1525-35. 2004..All active NAMI-A-type compounds share the capacity to modify important parameters of metastasis such as tumor invasion, matrix metallo proteinases activity and cell cycle progression...
- A Phase I and pharmacological study with imidazolium-trans-DMSO-imidazole-tetrachlororuthenate, a novel ruthenium anticancer agentJeany M Rademaker-Lakhai
The Netherlands Cancer Institute, Amsterdam, The Netherlands
Clin Cancer Res 10:3717-27. 2004..Furthermore, the ruthenium pharmacokinetics (PK) after NAMI-A administration and preliminary antitumor activity were evaluated...
- Assessment of tumor hypoxia by 62Cu-ATSM PET/CT as a predictor of response in head and neck cancer: a pilot studyYumiko Minagawa
Department of Radiology, Yokohama City University Graduate School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, Kanagawa, 236 0004, Japan
Ann Nucl Med 25:339-45. 2011..We undertook a pilot study in patients with locally advanced head and neck cancer to determine whether there is a relationship between tumor uptake of (62)Cu-ATSM and response to chemoradiotherapy...
- Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscleCamille Taillé
INSERM Unité 700 and Unité 683, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
J Biol Chem 280:25350-60. 2005..This study provides a new mechanism to explain redox signaling by CO...
- Hepatobiliary contrast agents for contrast-enhanced MRI of the liver: properties, clinical development and applicationsPeter Reimer
Department of Radiology, Stadtisches Klinikum Karlsruhe, Academic Teaching Hospital of the University of Freiburg, Moltkestrasse 90, 76133 Karlsruhe, Germany
Eur Radiol 14:559-78. 2004..No comparative studies have been conducted comparing the advantages or disadvantages of all three agents directly against each other...
- Tellurium tetrachloride and diphenyl ditelluride cause cytotoxicity in rat hippocampal astrocytesShalini Roy
Department of Pharmaceutical Sciences, College of Pharmacy and Allied Health Professions, St John s University, Jamaica, NY 11439, USA
Food Chem Toxicol 49:2564-74. 2011..We conclude that DPDT and TeCl(4) are cytotoxic to astrocytes. TeCl(4) treated cells die via the intrinsic apoptotic pathway. Accumulation of tellurium occurs with both compounds, but results in different mechanisms of cell death...
- Effectiveness of late gadolinium enhancement to improve outcomes prediction in patients referred for cardiovascular magnetic resonance after echocardiographyTimothy C Wong
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
J Cardiovasc Magn Reson 15:6. 2013..We assessed whether CMR improves outcomes prediction after contemporaneous echo, which may have implications for efforts to optimize processes of care, assess effectiveness, and allocate limited health care resources...
- A fluoride-derived electrophilic late-stage fluorination reagent for PET imagingEunsung Lee
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
Science 334:639-42. 2011..Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging...
- Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulatorsKelly S Davidge
Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Ct, Western Bank, Sheffield S10 2TN, United Kingdom
J Biol Chem 284:4516-24. 2009..Our discovery that CORM-3 is an effective inhibitor and global regulator of gene expression, especially under aerobic conditions, has important implications for administration of CO-releasing agents in sepsis and inflammation...
- Immunomodulating tellurium compounds as anti-cancer agentsBenjamin Sredni
The Safdié Institute for AIDS and Immunology Research, The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel
Semin Cancer Biol 22:60-9. 2012..These properties, coupled with the excellent safety profile of the compounds, suggest promising anti-cancer therapeutic potential for tellurium compounds such as AS101 or SAS...
- Soft porous crystalsSatoshi Horike
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo ku, Kyoto 615 8510, Japan
Nat Chem 1:695-704. 2009..We discuss the relationship between the structures and properties of these materials in view of their practical applications...
- Carbon monoxide releasing molecule-2 CORM-2 represses global protein synthesis by inhibition of eukaryotic elongation factor eEF2Christian Ingo Schwer
Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Hugstetterstrasse 55, D 79106 Freiburg, Germany
Int J Biochem Cell Biol 45:201-12. 2013..However, prolonged exogenous application of CO might also have negative effects on cellular protein homeostasis...
- Diphenyl ditelluride targets brain selenoproteins in vivo: inhibition of cerebral thioredoxin reductase and glutathione peroxidase in mice after acute exposureBruna Comparsi
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
Mol Cell Biochem 370:173-82. 2012..In particular the inhibition of important selenoenzymes (TrxR and GPx) seems to be involved in the neurotoxicity associated with (PhTe)(2) exposure in adult mice...
- Internal radiotherapy with copper-64-diacetyl-bis (N4-methylthiosemicarbazone) reduces CD133+ highly tumorigenic cells and metastatic ability of mouse colon carcinomaYukie Yoshii
Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui 910 1193, Japan
Nucl Med Biol 38:151-7. 2011..In this study, we evaluated the therapeutic effect of (64)Cu-ATSM in relation to CD133 expression using this model...
- Live cell luminescence imaging as a function of delivery mechanismXiaohe Tian
Department of Biomedical Science, The University of Sheffield, Sheffield S10 7TN, UK
Chembiochem 12:548-51. 2011..This change in delivery route, determines the final cellular location of the probe and thus modulates its imaging properties...
- Crystal structures of Λ-[Ru(phen)₂dppz]²⁺ with oligonucleotides containing TA/TA and AT/AT steps show two intercalation modesHakan Niyazi
Department of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK
Nat Chem 4:621-8. 2012..The TA/TA specificity of the perpendicular intercalation arises from the packing of phenanthroline ligands against the adenosine residue...
- p38β-regulated induction of the heat shock response by carbon monoxide releasing molecule CORM-2 mediates cytoprotection in lung cells in vitroNils Schallner
Department of Anesthesiology and Critical Care Medicine, University Medical Center, Freiburg, Germany
Eur J Pharmacol 670:58-66. 2011..Furthermore, the p38β isoform activation may represent an upstream mechanism of heat shock response induction...
- Nephrogenic systemic fibrosis: risk factors and incidence estimationElizabeth A Sadowski
Department of Radiology, University of Wisconsin, Madison, WI 53792 3252, USA
Radiology 243:148-57. 2007..To retrospectively review data in 13 patients with biopsy-confirmed nephrogenic systemic fibrosis (NSF), assess the associated risk factors, and report the incidence of NSF at the authors' institution...
- Treatment of Mediterranean visceral leishmaniasisL Gradoni
Laboratorio di Parassitologia, , Rome, Italy
Bull World Health Organ 73:191-7. 1995....
- Energy metabolism transition in multi-cellular human tumor spheroidsSara Rodriguez-Enriquez
Departamento de Bioquimica, Instituto Nacional de Cardiologia, Mexico, Mexico
J Cell Physiol 216:189-97. 2008..These results suggest that glycolysis and OxPhos might be considered as metabolic targets to diminish cellular proliferation in poorly vascularized, hypoxic solid tumors...
- Comparative study of the physicochemical properties of six clinical low molecular weight gadolinium contrast agentsSophie Laurent
Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons Hainaut, 24 Avenue du Champ de Mars, B 7000 Mons, Belgium
Contrast Media Mol Imaging 1:128-37. 2006..As a result, the relaxivity of MultiHance in HSA-containing media of fixed concentration decreases with increasing concentration of the contrast agent...
- A ruthenium(II) polypyridyl complex for direct imaging of DNA structure in living cellsMartin R Gill
Department of Chemistry, University of Sheffield, Sheffield, UK
Nat Chem 1:662-7. 2009....
- Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblastsSteeve Kwan Tat
Osteoarthritis Research Unit, University of Montreal Hospital Research Centre, Montreal, Quebec, Canada
Bone 49:559-67. 2011..In this study, we investigated in human OA subchondral bone osteoblasts the modulatory effect of strontium ranelate on the above key factors...
- Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic miceGediminas Cepinskas
Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, N6A 4G4, Canada
Am J Physiol Gastrointest Liver Physiol 294:G184-91. 2008....
- Interaction of [Ru(bpy)2(dppz)]2+ with human telomeric DNA: preferential binding to G-quadruplexes over i-motifShuo Shi
Department of Chemistry, Tongji University, Shanghai, PR China
Biochimie 92:370-7. 2010..The results also indicated that [Ru(bpy)(2)(dppz)](2+) could serve as a prominent molecular "light switch" for both G-quadruplexes, revealing a potential application of the title complex in luminescent signaling of G-quadruplex DNA...
- Carbon monoxide from CORM-2 reduces HMGB1 release through regulation of IFN-β/JAK2/STAT-1/INOS/NO signaling but not COX-2 in TLR-activated macrophagesKonstantin Tsoyi
Department of Pharmacology, School of Medicine and Institute of Life Sciences, Gyeongsang National University, Jinju, Gyeongsang, Korea
Shock 34:608-14. 2010....
- A randomized comparison of quadruple and triple therapies for Helicobacter pylori eradication: The QUADRATE StudyPeter H Katelaris
Department of Gastroenterology, Concord Hospital, University of Sydney, West, Australia
Gastroenterology 123:1763-9. 2002..Direct comparisons of bismuth and proton pump inhibitor (PPI)-based triple and quadruple therapies for Helicobacter pylori eradication are lacking. To address this, a randomized study was conducted...
- Evaluation of unusual neuroendocrine tumours by means of 68Ga-DOTA-NOC PETStefano Fanti
Unità Operativa di Medicina Nucleare, Policlinico S Orsola Malpighi, Bologna, Italy
Biomed Pharmacother 62:667-71. 2008..On the other hand, care has to be paid when studying lesions localized at sites of physiological concentration of the tracer, and in presence of inflammation...
- Regional convection-enhanced delivery of gadolinium-labeled albumin in the rat hippocampus in vivoGarrett W Astary
Department of Biomedical Engineering, University of Florida, Gainesville, FL, United States
J Neurosci Methods 187:129-37. 2010..Therefore, CED, combined with high-resolution MR imaging, may be a useful strategy for delivering therapeutics for the treatment of CNS disorders affecting the hippocampus...
- Strontium ranelate does not stimulate bone formation in ovariectomized ratsR K Fuchs
Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA
Osteoporos Int 19:1331-41. 2008..We evaluated the effects of SrR on the skeleton in ovariectomized (OVX) rats and evaluated the influence of dietary calcium...
- Evaluation of techniques for the quantification of myocardial scar of differing etiology using cardiac magnetic resonanceAndrew S Flett
Department of Cardiology, The Heart Hospital, University College London Hospitals NHS Trust, London, UK
JACC Cardiovasc Imaging 4:150-6. 2011....
- Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatmentPaul Roschger
Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, 4th Medical Department, Hanusch Hospital, 1140 Vienna, Austria
J Bone Miner Res 25:891-900. 2010..Taken together, these data provide evidence that the investigated bone quality determinants at tissue level were preserved in postmenopausal osteoporotic women after 3-year treatment with 2 g SrR per day plus calcium and vitamin D...
- Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosisEmma D Deeks
Adis, Auckland, New Zealand
Drugs 70:733-59. 2010..Overall, the clinical data available suggest that strontium ranelate is an effective and generally well tolerated option for the first-line treatment of postmenopausal osteoporosis...
- A carbon monoxide-releasing molecule (CORM-3) exerts bactericidal activity against Pseudomonas aeruginosa and improves survival in an animal model of bacteraemiaMathieu Desmard
INSERM U700, Faculte de Medecine, Universite Paris 7, Paris, France
FASEB J 23:1023-31. 2009..aeruginosa bacteremia. Our results suggest that CORMs could form the basis for developing a new therapeutic strategy against P. aeruginosa-induced infection...
- The interaction of MS-325 with human serum albumin and its effect on proton relaxation ratesPeter Caravan
EPIX Medical, Inc, 71 Rogers Street, Cambridge, MA 02142 1118, USA
J Am Chem Soc 124:3152-62. 2002..0 x 10(8) s(-1) bound vs 1.1 x 10(9) s(-1) free) and an increase in the inner-sphere water residency time (tau(m) = 170 +/- 40 ns bound vs 69 +/- 20 ns free)...
- The CO-releasing molecule CORM-3 protects against articular degradation in the K/BxN serum transfer arthritis modelNuria Maicas
Department of Pharmacology, University of Valencia, Av Vicent Andres Estelles s n, 46100 Burjasot, Valencia, Spain
Eur J Pharmacol 634:184-91. 2010..Pharmacological CO delivery represents a novel strategy to regulate the effector phase of arthritis...
- Strontium ranelate promotes osteoblastic cell replication through at least two different mechanismsJoseph Caverzasio
Service of Bone Diseases, Department of Rehabilitation and Geriatrics, University Hospital of Geneva, CH 1211 Geneva 14, Switzerland
Bone 42:1131-6. 2008....
- Bone marrow dosimetry in peptide receptor radionuclide therapy with [177Lu-DOTA(0),Tyr(3)]octreotateFlavio Forrer
Department of Nuclear Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 40, NL 3015 GD, Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 36:1138-46. 2009..Also, we evaluated the absorbed cross-dose from the source organs (liver, spleen, kidneys and blood), tumours and the so-called "remainder of the body" to the bone marrow...
- Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cellsChristiano M V Barbosa
Centro Interdisciplinar de Investigação Bioquímica, Universidade de Mogi das Cruzes, Mogi das Cruzes, SP, Brazil
Eur J Pharmacol 542:37-47. 2006..Taken together, these data suggest a novel lysosomal pathway for BPC-induced apoptosis, in which lysosomes are the primary target and cathepsin B acts as death mediator...
- The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosisPierre J Meunier
Department of Rheumatology and Bone Diseases, Edouard Herriot Hospital, Lyons, France
N Engl J Med 350:459-68. 2004....
- Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survivalDik J Kwekkeboom
Department of Nuclear Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
J Clin Oncol 26:2124-30. 2008..Here we report on the toxicity and efficacy of this treatment, performed in over 500 patients...
- Thiol-induced reduction of antimony(V) into antimony(III): a comparative study with trypanothione, cysteinyl-glycine, cysteine and glutathioneClaúdio dos Santos Ferreira
Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, 31270 901 Belo Horizonte, Minas Gerais, Brazil
Biometals 16:441-6. 2003..In conclusion, our data supports the hypothesis that Sb(V) is reduced in vivo by T(SH)2 within Leishmania parasites and by Cys or Cys-Gly within the acidic compartments of mammalian cells...
- Decreased sensitivity to meglumine antimoniate (Glucantime) of Leishmania infantum isolated from dogs after several courses of drug treatmentM Gramiccia
Laboratorio di Parassitologia, , Rome, Italy
Ann Trop Med Parasitol 86:613-20. 1992..This result underlines the futility and danger of repeated antimonial treatments of dogs with signs of leishmaniasis, as these may produce a permanent reservoir of parasites unsusceptible to the drugs in human clinical use...
- Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVECBingwei Sun
Department of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, Jiangsu Province, PR China
Int J Biol Sci 4:270-8. 2008..To investigate the effects and potential mechanisms of preconditioning of tricarbonyldichlororuthenium (III) dimer (CORM-2)-liberated CO on LPS-induced activation of endothelial cells (HUVEC)...
- Assessing tumor hypoxia in cervical cancer by PET with 60Cu-labeled diacetyl-bis(N4-methylthiosemicarbazone)Farrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
J Nucl Med 49:201-5. 2008..9). Pretherapy (60)Cu-ATSM PET provides clinically relevant information about tumor oxygenation that is predictive of outcome in patients with cervical cancer...
- Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strengthPatrick Ammann
Division of Bone Diseases, WHO Collaborting Centre for Osteoporosis Prevention, Department of Rehabilitation and Geriatrics, University Hospitals, Geneva, Switzerland
J Bone Miner Res 22:1419-25. 2007....
- Heme-oxygenase-1 induction and carbon monoxide-releasing molecule inhibit lipopolysaccharide (LPS)-induced high-mobility group box 1 release in vitro and improve survival of mice in LPS- and cecal ligation and puncture-induced sepsis model in vivoKonstantin Tsoyi
Department of Pharmacology, School of Medicine, Gyeongsang National University, Jinju, Republic of Korea
Mol Pharmacol 76:173-82. 2009..Taken together, we concluded that HO-1-derived CO reduces HMGB1 release in LPS-activated cells and LPS- or CLP-induced animal model of sepsis...
- Efficacy of miltefosine for the treatment of American cutaneous leishmaniasisIván Vélez
Universidad de Antioquia, Medellin, Colombia
Am J Trop Med Hyg 83:351-6. 2010....
- DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen speciesStephen Nesnow
Environmental Carcinogenesis Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Chem Res Toxicol 15:1627-34. 2002..These data are consistent with the conclusions that the DNA-damaging activity of DMA(III) is an indirect genotoxic effect mediated by ROS-formed concomitantly with the oxidation of DMA(III) to DMA(V)...
- Cardioprotective actions by a water-soluble carbon monoxide-releasing moleculeJames E Clark
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
Circ Res 93:e2-8. 2003..The full text of this article is available online at http://www.circresaha.org...
- Treatment failure in children in a randomized clinical trial with 10 and 20 days of meglumine antimonate for cutaneous leishmaniasis due to Leishmania viannia speciesR Palacios
Centro Internacional de Entrenamiento e Investigaciones Medicas, Cali, Colombia
Am J Trop Med Hyg 64:187-93. 2001..Pathogenicity of infection and pharmacokinetics may affect the treatment response in children. New therapeutic alternatives should be evaluated in trials that include children and women...
- In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSMFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 30:844-50. 2003..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
- Determination of monomethylarsonous acid, a key arsenic methylation intermediate, in human urineX C Le
University of Alberta, Department of Public Health Sciences, Edmonton, Alberta, Canada
Environ Health Perspect 108:1015-8. 2000..Along with the presence of MMA(III), there was an increase in the relative concentration of MMA(V) and a decrease in DMA(V) in the urine samples collected after the DMPS ingestion...
- Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimeticsRuolan Liu
Neuroscience Program, University of Southern California, Los Angeles, CA 90090 2520, USA
Proc Natl Acad Sci U S A 100:8526-31. 2003..These results further support the role of reactive oxygen species in age-related learning impairment and suggest potential clinical applications for synthetic catalytic scavengers of reactive oxygen species...
- Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing moleculeRoberta Foresti
Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex
Br J Pharmacol 142:453-60. 2004....
- Hepatobiliary-specific MR contrast agents: role in imaging the liver and biliary treeMelanie K Seale
Division of Abdominal Imaging and Intervention, Massachusetts General Hospital, White 270, 55 Fruit St, Boston, MA 02114, USA
Radiographics 29:1725-48. 2009..In the future, hepatobiliary-specific contrast agents may have wider applications, such as grading of cirrhosis and quantification of liver function...
- Treatment of patients with gastro-entero-pancreatic (GEP) tumours with the novel radiolabelled somatostatin analogue [177Lu-DOTA(0),Tyr3]octreotateD J Kwekkeboom
Department of Nuclear Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 30:417-22. 2003..However, in view of the high success rate of therapy with (177)Lu-octreotate and the absence of serious side-effects, we advocate its use in patients with GEP tumours without waiting for tumour progression...
- A comparison of (111)In-DOTATOC and (111)In-DOTATATE: biodistribution and dosimetry in the same patients with metastatic neuroendocrine tumoursF Forrer
Institute of Nuclear Medicine, University Hospital, Petersgraben 4, 4031, Basel, Switzerland
Eur J Nucl Med Mol Imaging 31:1257-62. 2004....
- Comparison of [(177)Lu-DOTA(0),Tyr(3)]octreotate and [(177)Lu-DOTA(0),Tyr(3)]octreotide: which peptide is preferable for PRRT?J P Esser
Department of Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands
Eur J Nucl Med Mol Imaging 33:1346-51. 2006..We compared in seven patients [(177)Lu-DOTA(0),Tyr(3)]octreotide ((177)Lu-DOTATOC) and [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-DOTATATE), to see which peptide should be preferred for PRRT with (177)Lu...
- Recent advances involving palladium (II) complexes for the cancer therapyAntonio Carlos Favero Caires
Centro Interdisciplinar de Investigação Bioquímica CIIB, Universidade de Mogi das Cruzes, Av Cândido Xavier de Almeida Souza, 200 CEP 08701 970, CP 411, Mogi das Cruzes SP, Brazil
Anticancer Agents Med Chem 7:484-91. 2007..New palladacycle compounds derived from N,N-dimethyl-1-phenethylamine and the ligand bis(diphenylphosphine)ferrocene were presented as effective antitumoral agents...
- Canine leishmaniasis: clinical, parasitological and entomological follow-up after chemotherapyJ Alvar
Laboratorio de Referencia de Leishmaniasis, Instituto de Salud Carlos III, Madrid, Spain
Ann Trop Med Parasitol 88:371-8. 1994..Some dogs from both the 'asymptomatic' and 'symptomatic' groups became infective to sandflies several months post-treatment...
- Metal-intercalated aromatic hydrocarbons: a new class of carbon-based superconductorsYoshihiro Kubozono
Research Laboratory for Surface Science, Okayama University, Okayama, Japan
Phys Chem Chem Phys 13:16476-93. 2011..The features of other carbon-based superconductors are compared to clarify the nature of hydrocarbon superconductors...
- A synthetic model of the Mn₃Ca subsite of the oxygen-evolving complex in photosystem IIJacob S Kanady
Department of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard MC 127 72, Pasadena, CA 91125, USA
Science 333:733-6. 2011....
- Efficacy and safety of oral strontium ranelate for the treatment of knee osteoarthritis: rationale and design of randomised, double-blind, placebo-controlled trialCyrus Cooper
MRC Lifecourse Epidemiology Unit, University of Southampton and NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, UK
Curr Med Res Opin 28:231-9. 2012..We describe the rationale and design of a randomised trial evaluating the efficacy and safety of strontium ranelate in knee osteoarthritis...
- Protective effect of naringenin against lead-induced oxidative stress in ratsJicang Wang
College of Animal Science and Technology, Henan University of Science and Technology, No 70, Tianjin Road, 471003, Luoyang, People s Republic of China
Biol Trace Elem Res 146:354-9. 2012..05). The present study suggests that naringenin shows antioxidant activity and plays a protective role against lead-induced oxidative damage in the liver and kidney of rats...
- Evaluation of striatal oxidative stress in patients with Parkinson's disease using [62Cu]ATSM PETMasamichi Ikawa
Second Department of Internal Medicine Neurology, Faculty of Medical Sciences, University of Fukui, Eiheiji cho, Fukui 910 1193, Japan
Nucl Med Biol 38:945-51. 2011....
- Gallium compound GaQ(3) -induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cellsRajan Gogna
Transcription and Human Biology Laboratory, School of Biotechnology, Jawaharlal Nehru University, New Delhi, India
Br J Pharmacol 166:617-36. 2012..Understanding the mechanism of GaQ(3) -induced apoptosis will help establish this gallium-based organic compound as a potent anti-cancer drug...
- Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) studyJ Y Reginster
Department of Epidemiology, Public Health and Health Economics, University of Liege, CHU Centre Ville, 45 Quai Godefroid Kurth, 4020 Liege, Belgium
J Clin Endocrinol Metab 90:2816-22. 2005....
- CMR assessment of endothelial damage and angiogenesis in porcine coronary arteries using gadofosvesetSteen F Pedersen
Department of Cardiothoracic and Vascular Surgery T, Aarhus University Hospital Skejby, Aarhus N, Denmark
J Cardiovasc Magn Reson 13:10. 2011..We sought to examine whether contrast enhanced cardiovascular magnetic resonance (CMR) using gadofosveset could show endothelial damage and neovessel formation in balloon injured porcine coronary arteries...
- En route to osmium analogues of KP1019: synthesis, structure, spectroscopic properties and antiproliferative activity of trans-[Os(IV)Cl4(Hazole)2]Gabriel E Büchel
University of Vienna, Institute of Inorganic Chemistry, Währinger Strasse 42, A 1090 Vienna, Austria
Inorg Chem 50:7690-7. 2011..Their antiproliferative acitivity in the human cancer cell lines CH1 (ovarian carcinoma), A549 (nonsmall cell lung carcinoma), and SW480 (colon carcinoma) is reported...
- Quality of life in 265 patients with gastroenteropancreatic or bronchial neuroendocrine tumors treated with [177Lu-DOTA0,Tyr3]octreotateSaima Khan
Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Nucl Med 52:1361-8. 2011..In this study, we investigated the QOL and symptoms after [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate) therapy in patients with inoperable or metastasized gastroenteropancreatic or bronchial neuroendocrine tumors (NETs)...
- Immobilization of MP-11 into a mesoporous metal-organic framework, MP-11@mesoMOF: a new platform for enzymatic catalysisVasiliki Lykourinou
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA
J Am Chem Soc 133:10382-5. 2011....
- Peptide receptor radionuclide therapy with ¹⁷⁷Lu-DOTATATE: the IEO phase I-II studyLisa Bodei
Division of Nuclear Medicine, European Institute of Oncology, Via Ripamonti, 435 20141 Milan, Italy
Eur J Nucl Med Mol Imaging 38:2125-35. 2011..The aim of this prospective phase I-II study was to evaluate the toxicity and efficacy of (177)Lu-DOTATATE in multiple cycles...
- Partition coefficients for gadolinium chelates in the normal myocardium: comparison of gadopentetate dimeglumine and gadobenate dimeglumineNadine Kawel
Radiology and Imaging Sciences, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
J Magn Reson Imaging 36:733-7. 2012....
- Facile synthesis of pegylated zinc(II) phthalocyanines via transesterification and their in vitro photodynamic activitiesMing Bai
Department of Chemistry, The Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
Org Biomol Chem 9:7028-32. 2011..3 to 79.8 nm depending on the preparation methods and conditions. The photocytotoxicity of these nanoparticles (IC(50) = 0.43-0.56 μM) was comparable with that of the Cremophor EL-formulated system (IC(50) = 0.34 μM)...
- Performance of delayed-enhancement magnetic resonance imaging with gadoversetamide contrast for the detection and assessment of myocardial infarction: an international, multicenter, double-blinded, randomized trialRaymond J Kim
Duke Cardiovascular MRI Center, DUMC 3934, Durham, NC 27710, USA
Circulation 117:629-37. 2008..We prospectively tested the performance of delayed-enhancement magnetic resonance imaging (MRI) with gadolinium-based contrast for the detection of MI in an international, multicenter trial...
- Diacetylbis(N(4)-methylthiosemicarbazonato) copper(II) (CuII(atsm)) protects against peroxynitrite-induced nitrosative damage and prolongs survival in amyotrophic lateral sclerosis mouse modelCynthia P W Soon
Department of Pathology, Mental Health Research Institute, School of Chemistry, The University of Melbourne, Parkville, Victoria, Australia
J Biol Chem 286:44035-44. 2011..CuII(atsm) therefore represents a potential new class of neuroprotective agents targeting multiple major disease pathways of motor neurons with therapeutic potential for ALS...
- Safety of gadobutrol, a new generation of contrast agents: experience from clinical trials and postmarketing surveillanceMatthias Voth
Bayer HealthCare Pharmaceutical, Schering Pharma AG, Global Medical Affairs Diagnostic Imaging, Berlin, Germany
Invest Radiol 46:663-71. 2011..To assess the clinical safety and tolerability of the macrocyclic contrast agent gadobutrol (Gadovist/Gadavist) overall and in specific patient populations based on clinical trials and postmarketing experience...
- Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluorideEunsung Lee
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
J Am Chem Soc 134:17456-8. 2012....
- Comparative in vivo stability of copper-64-labeled cross-bridged and conventional tetraazamacrocyclic complexesC Andrew Boswell
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Med Chem 47:1465-74. 2004..These findings further suggest that a bifunctional chelator derivative of CB-TE2A is a highly desirable alternative for labeling copper radionuclides to biological molecules for diagnostic imaging and targeted radiotherapy...
- Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: Results of a five-year, randomized, placebo-controlled trialJean Yves Reginster
University of Liege, Liege, Belgium
Arthritis Rheum 58:1687-95. 2008..This study was undertaken to assess the effect of strontium ranelate on nonvertebral and vertebral fractures in postmenopausal women with osteoporosis in a 5-year, double-blind, placebo-controlled trial...
- Peripheral magnetic resonance angiography with continuous table movement in combination with high spatial and temporal resolution time-resolved MRA With a total single dose (0.1 mmol/kg) of gadobutrol at 3.0 TMatthias Voth
University Medical Center Mannheim, Institute of Clinical Radiology and Nuclear Medicine, University of Heidelberg, Mannheim, Germany
Invest Radiol 44:627-33. 2009..0 T with a single dose (0.1 mmol/kg) of gadobutrol in total...
- Contrast material for abdominal dynamic contrast-enhanced 3D MR angiography with parallel imaging: intraindividual equimolar comparison of a macrocyclic 1.0 M gadolinium chelate and a linear ionic 0.5 M gadolinium chelateDariusch Reza Hadizadeh
Department of Radiology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
AJR Am J Roentgenol 194:821-9. 2010..0 M contrast agent with a linear ionic 0.5 M contrast agent at equimolar dosage in regard to image quality and number of vessel segments visualized at abdominal dynamic contrast-enhanced 3D MR angiography...
- Multicentric, controlled clinical study to evaluate effectiveness and safety of miltefosine and allopurinol for canine leishmaniosisGuadalupe Miró
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain
Vet Dermatol 20:397-404. 2009..Miltefosine, in combination with allopurinol, offers a safe, convenient and effective alternative treatment option for canine leishmaniosis compared to the reference therapy...
- Comparative study on the short term efficacy and adverse effects of miltefosine and meglumine antimoniate in dogs with natural leishmaniosisMarta Mateo
Dpto Sanidad Animal, Universidad Complutense de Madrid, Spain
Parasitol Res 105:155-62. 2009....
- Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imagingPatricia Horcajada
Institut Lavoisier CNRS 8180 Institut universitaire de France, Universite de Versailles, 78035 Versailles Cedex, France
Nat Mater 9:172-8. 2010..In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments...
- Titanium-gold-based chemotherapeutics for prostate and kidney cancerMaria Contel; Fiscal Year: 2013..We will synthesize new titanium organometallic compounds with phosphine-, and iminophosphorane-modified cyclopentadienyl (Cp) ligands able to further coordinate ..
- Base-selective heavy atom labels for electron microscopy-based DNA sequencingF D Toste; Fiscal Year: 2012..PUBLIC HEALTH RELEVANCE: The proposed program aims to develop heavy atom organometallic compounds for ssDNA base-selective labeling for use in ultra-low-cost DNA sequencing technology based on single- ..
- Acquisition of a High Resolution TOF Mass SpectrometerTadeusz F Molinski; Fiscal Year: 2010..coupled with an HPLC for accurate mass determination of small molecules such as natural products, organometallic compounds, nucleic acids and non-polar organic synthetic intermediates that are generated in the research groups of ..
- RADIOPAQUE ADHESIVES AND DENTAL RESTORATIVE RESINSISRAEL CABASSO; Fiscal Year: 2000..This approach evolved to include organometallic compounds, monomers and polymers in which the metal is covalently bound to the organic structure...
- ENERGETICS AND DYNAMICS OF ORGANOMETALLIC REACTIONSGILBERT YANG; Fiscal Year: 1993The reactions of organometallic compounds play a central role in a great variety of important reactions...
- PURCHASE OF A MAGNETIC SECTOR MASS SPECTROMETERJoseph Marino; Fiscal Year: 2001..The first purpose is obtaining full mass range, unit mass resolution spectra of organic and organometallic compounds in order to confirm identity and access purity...
- MINORITY HIGH SCHOOL STUDENT RESEARCH APPRENTICE PROGRAMHarold Swartz; Fiscal Year: 1990..Synthesis of DNA and RNA: 3. Synthetic methods and total synthesis of organic and organometallic compounds; 4. Conformational analysis of organic and organometallic compounds...
- ION TRAP AND DATA SYSTEM UPGRADE FOR MCMSMichael Gross; Fiscal Year: 1990..service will be offered for local NIH-supported investigators, who need to prove structure of new organometallic compounds, and for at least ten NIH-funded researchers from outside the University of Nebraska...
- Catalytic Processes for Selective Organic SynthesisGARY MOLANDER; Fiscal Year: 2005..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
- Agilent 5973 GC/MS SystemGARY MOLANDER; Fiscal Year: 2002..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
- Adjuvant Therapy for Vascular Inflammation in DiabetesSushil Jain; Fiscal Year: 2006..abstract_text> ..
- Mitochondrial control of neuronal excitotoxicityDavid Nicholls; Fiscal Year: 2005..4. To test the hypothesis that mitochondria at specific intracellular locations may be selectively vulnerable to glutamate excitotoxicity because of their proximity to NMDA receptors, or their location in regions of high-energy demand. ..
- Aging-Related Models and Mitochondrial BioenergeticsDavid Nicholls; Fiscal Year: 2006..3. To indicate therapeutic strategies whereby the deleterious consequences of aging-related changes in mitochondrial function can be minimized. ..
- HIGH-RISK NEUROBLASTOMA: A DEVASTATING CHILDHOOD CANCERLaurent Brard; Fiscal Year: 2008..B3CD could potentially be used alone or in combination with standard chemotherapy to treat this devastating illness. ..
- NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONSP Evans; Fiscal Year: 2006..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
- Nicotine and Cognition in ParkinsonismJay Schneider; Fiscal Year: 2008..Information obtained from these studies will hopefully lead to more efficient design of nicotinic therapeutics for patients with a variety of cognitive disorders. ..
- CHEMICAL SENSORS FOR CELLULAR CONDITIONS AND COMPONENTSTIMOTHY GLASS; Fiscal Year: 2008..Biological studies will be performed with the aid of collaborators in which cells will be stained with the fluorescent sensors and the location and concentration of neurotransmitter will be measured. ..
- GM1 Ganglioside Effects on Parkinson's DiseaseJay Schneider; Fiscal Year: 2007..Working hypothesis: Long-term GM1 use will stabilize symptoms or slow the progression of symptoms in PD patients and this may be accompanied by reduced loss of striatal DA terminals over time. [unreadable] [unreadable]..
- Center for Pediatric Stem/Progenitor Cell Translational ResearchAlice Tarantal; Fiscal Year: 2008..If imaging techniques can be developed that allows one to monitor the cells over time, this would provide a very powerful tool to determine the fate of the cells after injection into humans. ..
- Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic PatientsSushil K Jain; Fiscal Year: 2010..The long-term goal is to understand the role of ketosis in CVD and to discover a relatively low-cost dietary supplement that could be used as an adjuvant therapy for CVD prevention in type 1 diabetes. ..
- ELECTRON-TRANSFER PROTEINSFRANCIS S contact MILLETT; Fiscal Year: 2010..In the proposed studies, new ruthenium photoexcitation methods will be developed to study electron transfer reactions important to human health. ..
- Design of New Treatment Agents for Drug AbuseHUW M DAVIES; Fiscal Year: 2010..This will be achieved through a multidisciplinary research program combining organic synthesis, medicinal chemistry, pharmacology and behavioral physiology, exploring the efficacy of a new class of 5HT2A receptor antagonists. ..
- CENTER FOR PROTEIN STRUCTURE AND FUNCTIONFrancis Millett; Fiscal Year: 2009..abstract_text> ..
- Application of C-H Activation to Natural Product SynthesisHUW M DAVIES; Fiscal Year: 2010....
- Controlled Catalytic Reduction of Dinitrogen at a Transition Metal CenterRichard R Schrock; Fiscal Year: 2010..abstract_text> ..
- Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.BARRY TROST; Fiscal Year: 2009..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
- Imaging Thymidine Uptake During Treatment for Head and Neck CancerYusuf Menda; Fiscal Year: 2008..The studies proposed here will refine and characterize a non-invasive imaging test that may allow treatment responses to be determined shortly after treatment has begun. [unreadable] [unreadable] [unreadable]..
- Mesenchymal Stem Cells for Fetal Gene DeliveryAlice Tarantal; Fiscal Year: 2006..abstract_text> ..
- Calcium entry and vascular smooth muscle excitationKENNETH BYRON; Fiscal Year: 2006..abstract_text> ..
- MIBG ANALOGUE RADIOPHARMACEUTICALSGanesan Vaidyanathan; Fiscal Year: 2001..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
- Conference on Photodynamic TherapyDavid Kessel; Fiscal Year: 2002..The most recent PDT meeting, sponsored by the International Photodynamic Assn, has more than 600 participants. ..
- SYNTHESIS AND EVALUATION OF NOVEL COCAINE ANALOGSHuw Davies; Fiscal Year: 2002..The proposed studies will ensure that a greater structural diversity is brought into the types of compounds that will be considered as potential medications for the treatment of cocaine addiction. ..
- SIGNALING BY VASOPRESSIN--ARTERIAL SMOOTH MUSCLE CELLSKENNETH BYRON; Fiscal Year: 2002..Finally, the effects of AVP and other hormones on [Ca2+]i and membrane currents will be examined in freshly isolated smooth muscle cells from rat mesenteric arteries. ..
- STRUCTURAL BASIS OF INSULIN MIMETIC EFFECT OF VANADYLMARVIN MAKINEN; Fiscal Year: 2003..abstract_text> ..
- Promotion of PDT Induced phototoxicity by bile acidsDavid Kessel; Fiscal Year: 2003..If the results of preliminary studies are borne out by further investigation, UDCA could offer a safe and effective means for promoting clinical PDT efficacy. ..
- Pretargeting mouse tumor with anti-PSMA antibody-MORFGuozheng Liu; Fiscal Year: 2005..Based on our experiences in this pretargeting strategy, we are confident that these investigations on the pretargeting imaging of prostate cancer models with MORFs will be successful. ..
- Attention in Children with the 22q11 Deletion SyndromeChristina Sobin; Fiscal Year: 2005....
- Center for Fetal Gene Transfer for HLB DiseasesAlice Tarantal; Fiscal Year: 2005..abstract_text> ..
- Methylphenidate Analogs as Medications for Cocaine AbuseHuw Davies; Fiscal Year: 2006..Initial studies will also be carried out to determine if useful PET radioligands can be made from any potent and selective analogs that are discovered during these studies. ..
- Imaging of O6-Alkylguanine-DNA AlkyltransferaseGanesan Vaidyanathan; Fiscal Year: 2005..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
- STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERSP Evans; Fiscal Year: 2006..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
- Cortical CathetersMartin Brady; Fiscal Year: 2004..In Phase II or subsequent efforts, we will test the predictions of the models and simulations based on the hypotheses developed here, and evaluate the performance of SCD neurocatheters in an appropriate animal model. ..
- Proteomic determination of arsenical actionPartha Basu; Fiscal Year: 2005..These studies will greatly expand the understanding of the biochemical activation of vascular cell signaling that is relevant to arsenic-related vascular diseases. ..
- Effects of Dioxin on Vietnamese CiviliansDavid Carpenter; Fiscal Year: 2004..7. ..
- Phase II Trial of Thalidomide in Primary AmyloidosisAngela Dispenzieri; Fiscal Year: 2002..The ultimate goal of the proposed studies is to improve the prognosis of patient with this fatal disease. ..
- Functional active-site models of cytochrome c oxidaseJAMES COLLMAN; Fiscal Year: 2009..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
- PET Imaging of Breast Cancer Using Oncogene ExpressionMathew Thakur; Fiscal Year: 2008..abstract_text> ..
- PET for Molecular Imaging of Small AnimalsMathew Thakur; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- IMAGING THROMBOEMBOLISM WITH FIBRIN AVID TC-99M-PEPTIDEMathew Thakur; Fiscal Year: 2002..Because there are no agents currently available than can scintigraphically provide "hot spot" images of old (24 hr or older) clots and PE, the commercial potential for this agent is very high. ..