succinylcholine

Summary

Summary: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.

Top Publications

  1. ncbi Intraocular pressure changes after succinylcholine and endotracheal intubation: a comparison of thiopental and propofol on IOP
    M B Khosravi
    Indian J Ophthalmol 55:164. 2007
  2. ncbi Atropine, fentanyl and succinylcholine for non-urgent intubations in newborns
    B Lemyre
    University of Ottawa, Ottawa, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 94:F439-42. 2009
  3. ncbi Rocuronium is not associated with more vocal cord injuries than succinylcholine after rapid-sequence induction: a randomized, prospective, controlled trial
    Thomas Mencke
    Department of Anaesthesia and Intensive Care Medicine, University of Rostock, Rostock Germany
    Anesth Analg 102:943-9. 2006
  4. ncbi Suspected malignant hyperthermia reactions in New Zealand
    A N Pollock
    Department of Anaesthesia, Palmerston North Hospital, New Zealand
    Anaesth Intensive Care 30:453-61. 2002
  5. ncbi Succinylcholine in malignant hyperthermia: evaluation of a novel in vivo model
    Thomas Metterlein
    Department of Anesthesiology, University Hospital Wurzburg, Wurzburg, Germany
    Muscle Nerve 44:213-6. 2011
  6. ncbi Endotracheal intubation with thiopental/succinylcholine or sevoflurane-nitrous oxide anesthesia in adults: a comparative study
    A Iamaroon
    Department of Anesthesiology, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, 10700, Thailand
    Anesth Analg 92:523-8. 2001
  7. ncbi Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy
    A H Al-Khafaji
    Section of Critical Care Medicine, Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Crit Care Med 29:1274-6. 2001
  8. ncbi Controversies in rapid sequence intubation in children
    Audrey Zelicof-Paul
    Department of Pediatrics, Emergency Division, The Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Pediatr 17:355-62. 2005
  9. ncbi Rocuronium is the best non-depolarizing relaxant to prevent succinylcholine fasciculations and myalgia
    R Martin
    Department of Anaesthesia, Centre universitaire de sante de l Estrie, Fleurimont, Quebec, Canada
    Can J Anaesth 45:521-5. 1998
  10. ncbi Succinylcholine-induced hyperkalemia in a patient with multiple sclerosis
    Michael Levine
    Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, California 90033, USA
    J Emerg Med 43:279-82. 2012

Detail Information

Publications210 found, 100 shown here

  1. ncbi Intraocular pressure changes after succinylcholine and endotracheal intubation: a comparison of thiopental and propofol on IOP
    M B Khosravi
    Indian J Ophthalmol 55:164. 2007
  2. ncbi Atropine, fentanyl and succinylcholine for non-urgent intubations in newborns
    B Lemyre
    University of Ottawa, Ottawa, Ontario, Canada
    Arch Dis Child Fetal Neonatal Ed 94:F439-42. 2009
    Describe intubation conditions and adverse events when using atropine fentanyl +/- succinylcholine as premedication.
  3. ncbi Rocuronium is not associated with more vocal cord injuries than succinylcholine after rapid-sequence induction: a randomized, prospective, controlled trial
    Thomas Mencke
    Department of Anaesthesia and Intensive Care Medicine, University of Rostock, Rostock Germany
    Anesth Analg 102:943-9. 2006
    ..Thus, we tested the hypothesis that a rapid-sequence induction (RSI) with succinylcholine would lead to less PH and VCI than with rocuronium...
  4. ncbi Suspected malignant hyperthermia reactions in New Zealand
    A N Pollock
    Department of Anaesthesia, Palmerston North Hospital, New Zealand
    Anaesth Intensive Care 30:453-61. 2002
    ..This test also demonstrated the shortcomings of the Malignant Hyperthermia Clinical Grading Scale...
  5. ncbi Succinylcholine in malignant hyperthermia: evaluation of a novel in vivo model
    Thomas Metterlein
    Department of Anesthesiology, University Hospital Wurzburg, Wurzburg, Germany
    Muscle Nerve 44:213-6. 2011
    ..The exact mechanism of succinylcholine as an MH trigger cannot be examined in existing in vitro models...
  6. ncbi Endotracheal intubation with thiopental/succinylcholine or sevoflurane-nitrous oxide anesthesia in adults: a comparative study
    A Iamaroon
    Department of Anesthesiology, Siriraj Hospital, Faculty of Medicine, Mahidol University, Bangkok, 10700, Thailand
    Anesth Analg 92:523-8. 2001
    ..a double-blinded, prospective, randomized controlled trial to compare intubating conditions facilitated by succinylcholine or sevoflurane...
  7. ncbi Succinylcholine-induced hyperkalemia in a patient with mucositis secondary to chemotherapy
    A H Al-Khafaji
    Section of Critical Care Medicine, Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    Crit Care Med 29:1274-6. 2001
    OBJECTIVE: To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy. DESIGN: Case report...
  8. ncbi Controversies in rapid sequence intubation in children
    Audrey Zelicof-Paul
    Department of Pediatrics, Emergency Division, The Children s Hospital of New York Presbyterian, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Curr Opin Pediatr 17:355-62. 2005
    ..The purpose of the present review is to address several controversies pertaining to emergency department rapid sequence intubation of children...
  9. ncbi Rocuronium is the best non-depolarizing relaxant to prevent succinylcholine fasciculations and myalgia
    R Martin
    Department of Anaesthesia, Centre universitaire de sante de l Estrie, Fleurimont, Quebec, Canada
    Can J Anaesth 45:521-5. 1998
    To determine which non-depolarizing relaxant among d-tubocurarine, vecuronium, atracurium, mivacurium and rocuronium prevented muscular fasciculations and myalgia following succinylcholine.
  10. ncbi Succinylcholine-induced hyperkalemia in a patient with multiple sclerosis
    Michael Levine
    Department of Emergency Medicine, Section of Medical Toxicology, University of Southern California, Los Angeles, California 90033, USA
    J Emerg Med 43:279-82. 2012
    b>Succinylcholine administration is associated with hyperkalemia in patients with a variety of medical conditions, including many neuromuscular disorders...
  11. ncbi Estimate of the relative risk of succinylcholine for triggering malignant hyperthermia
    Franklin Dexter
    Division of Management Consulting, Department of Anesthesia, University of Iowa, 200 Hawkins Dr, 6JCP, Iowa City, IA 52242, USA
    Anesth Analg 116:118-22. 2013
    ..We considered the stocking of dantrolene at facilities with succinylcholine alone (i.e...
  12. pmc Remifentanil attenuates muscle fasciculations by succinylcholine
    Mi Ja Yun
    Department of Anaesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea
    Yonsei Med J 51:585-9. 2010
    The present visual and electromyographic study was designed to evaluate muscle fasciculations caused by succinylcholine in adults pretreated with either remifentanil 1.5 microg/kg or saline.
  13. ncbi Prehospital rapid sequence intubation in an emergency medical services system with two advanced life support providers
    Mark A Merlin
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Robert Wood Johnson University Hospital, New Brunswick, New Jersey 08901, USA
    Prehosp Disaster Med 25:341-5. 2010
    ..This is a report of the initial experience with the first 50 patients in a unique, two-tiered, two advanced life support (ALS) providers system...
  14. ncbi The management of succinylcholine apnoea
    I Barker
    Anaesthesia 58:1144. 2003
  15. ncbi Emergency airway management
    Vadym Gudzenko
    Department of Anesthesiology, Critical Care, and Pain Management, Massachusetts General Hospital, Gray Bigelow 444, 55 Fruit Street, Boston, MA 02114, USA
    Respir Care 55:1026-35. 2010
    ..Standardized algorithms may increase the success of emergency intubation. Attention should be paid to cardiopulmonary stability in the immediate post-intubation period...
  16. ncbi Prolonged succinylcholine apnoea resulting from acquired deficiency of plasma cholinesterase
    J C Norris
    Anaesthesia 58:1137. 2003
  17. ncbi Rapid sequence induction and intubation with rocuronium-sugammadex compared with succinylcholine: a randomized trial
    M K Sørensen
    Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark
    Br J Anaesth 108:682-9. 2012
    ..We hypothesized that the time period from tracheal intubation to spontaneous ventilation would be shorter with rocuronium-sugammadex than with succinylcholine.
  18. ncbi Frequency of haemoglobin desaturation with the use of succinylcholine during rapid sequence induction of anaesthesia
    A H Hayes
    Department of Anaesthetics and Intensive Care Medicine, The Queen's University of Belfast, Northern Ireland, UK
    Acta Anaesthesiol Scand 45:746-9. 2001
    BACKGROUND: The perceived safety of the use of succinylcholine is based on the fact that recovery from its effects will occur before oxygen desaturation occurs in case of failure to intubate or ventilate...
  19. ncbi Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: is rocuronium as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation?
    Adam Herbstritt
    Christchurch Hospital, New Zealand
    Emerg Med J 29:256-8. 2012
    A short-cut review was carried out to establish whether rocuronium is as effective as succinylcholine at facilitating laryngoscopy during rapid sequence intubation (RSI)...
  20. ncbi Succinylcholine: still beautiful and mysterious after all these years
    A Li Wan Po
    Centre for Evidence Based Pharmacotherapy, School of Life and Health Sciences, Aston University, Aston Triangle, UK
    J Clin Pharm Ther 30:497-501. 2005
  21. ncbi Rocuronium vs. succinylcholine in the emergency department: a critical appraisal
    William K Mallon
    Department of Emergency Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California, USA
    J Emerg Med 37:183-8. 2009
    ..available for rapid sequence intubation (RSI) in the emergency department (ED): depolarizing agents such as succinylcholine, and non-depolarizing drugs such as rocuronium...
  22. ncbi Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia
    Mona R Gätke
    Danish Cholinesterase Research Unit, Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Denmark
    Pharmacogenet Genomics 17:995-9. 2007
    Butyrylcholinesterase (BChE) hydrolyses the neuromuscular blocking agents, succinylcholine and mivacurium used during general anaesthesia...
  23. ncbi Pretreatment with magnesium sulphate is associated with less succinylcholine-induced fasciculation and subsequent tracheal intubation-induced hemodynamic changes than precurarization with vecuronium during rapid sequence induction
    S Sakuraba
    Department of Anesthesiology, School of Medicine, Keio University, Tokyo, Japan
    Acta Anaesthesiol Belg 57:253-7. 2006
    Although it has side effects, succinylcholine is still widely used in rapid sequence induction...
  24. ncbi Determination of butyrylcholinesterase (BChE) phenotypes to predict the risk of prolonged apnea in persons receiving succinylcholine in the healthy population of western Iran
    Asad Vaisi-Raygani
    Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran
    Clin Biochem 40:629-33. 2007
    ..of serum BChE assay is to predict abnormally prolonged apnea following the application of the muscle relaxant succinylcholine. The aim of the present study was to assess the frequency of BChE phenotypes and to predict the risk of apnea ..
  25. ncbi Impact of the intubation model on the efficacy of rocuronium during rapid sequence intubation: systematic review of randomized trials
    C Lysakowski
    Division of Anaesthesiology, University Hospitals of Geneva, Geneva, Switzerland
    Acta Anaesthesiol Scand 51:848-57. 2007
    ..Propofol-rocuronium is thought to be superior to thiopental-rocuronium for rapid sequence intubation (RSI). The role of the intubation model per se has never been investigated...
  26. ncbi Succinylcholine use in adult anesthesia - A multinational questionnaire survey
    Nenad Karanovic
    University of Split, Split University Hospital Center, Department of Anesthesiology and Intensive Care Medicine, Split, Croatia
    Coll Antropol 35:183-90. 2011
    There are no definitive evidence based standards regarding use of succinylcholine (SCh) for anesthesia induction. However, there is a global trend toward eliminating SCh not only in elective, but also in emergency surgery in adults...
  27. ncbi The continuing search for a succinylcholine replacement
    James E Caldwell
    Anesthesiology 100:763-4. 2004
  28. ncbi Succinylcholine: new insights into mechanisms of action of an old drug
    JEEVENDRA MARTYN
    Anesthesiology 104:633-4. 2006
  29. ncbi Oral clonidine premedication prevents the rise in intraocular pressure following succinylcholine administration
    H Polarz
    Klinik fur Anasthesiologie, Heidelberg, Germany
    Ger J Ophthalmol 2:97-9. 1993
    ..assess the effects of premedication with clonidine on intraocular pressure (IOP) after the administration of succinylcholine. Fifty elderly patients undergoing ophthalmic surgery were randomly allocated to two study groups...
  30. ncbi Paramedic-administered neuromuscular blockade improves prehospital intubation success in severely head-injured patients
    Daniel P Davis
    Department of Emergency Medicine, University of California, San Diego, California 92103 8676, USA
    J Trauma 55:713-9. 2003
    ....
  31. ncbi Prehospital use of succinylcholine: a 20-year review
    M A Wayne
    Emergency Medical Services, Bellingham Whatcom County Washington, WA 98225, USA
    Prehosp Emerg Care 3:107-9. 1999
    To determine the safety and efficacy of succinylcholine, as an adjunct to endotracheal intubation, administered by paramedics trained in its use.
  32. ncbi Will succinylcholine ever disappear?
    Ronald Miller
    Anesth Analg 98:1674-5. 2004
  33. pmc In patients with head injuries who undergo rapid sequence intubation using succinylcholine, does pretreatment with a competitive neuromuscular blocking agent improve outcome? A literature review
    M Clancy
    Emergency Department, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
    Emerg Med J 18:373-5. 2001
    A literature search was undertaken for evidence of the effect of succinylcholine (SCH) on the intracranial pressure (ICP) of patients with acute brain injury and whether pretreatment with a defasciculating dose of competitive ..
  34. ncbi Succinylcholine and the open eye
    Elie Joseph Chidiac
    Department of Anesthesiology, Wayne State University School of Medicine, Anesthesiology Education Office, Room 2901, 2 Hudson, 3990 John R, Detroit, MI 48201, USA
    Ophthalmol Clin North Am 19:279-85. 2006
    The use of succinylcholine in ocular trauma is controversial because it raises intraocular pressure...
  35. ncbi Reversal of profound neuromuscular block by sugammadex administered three minutes after rocuronium: a comparison with spontaneous recovery from succinylcholine
    Chingmuh Lee
    Department of Anesthesiology, David Geffen School of Medicine at University of California Los Angeles, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Anesthesiology 110:1020-5. 2009
    Rocuronium in intubation doses provides similar intubation conditions as succinylcholine, but has a longer duration of action...
  36. ncbi Rapacuronium: why did it fail as a replacement for succinylcholine?
    P F White
    Br J Anaesth 88:163-5. 2002
  37. ncbi A comparison of succinylcholine and rocuronium for rapid-sequence intubation of emergency department patients
    E G Laurin
    Division of Emergency Medicine, University of California, Davis, Medical Center, University of California, Davis, School of Medicine, Sacramento, CA, USA
    Acad Emerg Med 7:1362-9. 2000
    To compare rocuronium and succinylcholine for rapid-sequence intubation (RSI) in the emergency department (ED).
  38. ncbi Optimal dose of succinylcholine revisited
    Mohamed Naguib
    Department of Anesthesia, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Anesthesiology 99:1045-9. 2003
    The authors reappraised the conventional wisdom that the intubating dose of succinylcholine must be 1...
  39. ncbi Effects of high-dose propofol on succinylcholine-induced fasciculations and myalgia
    A Kararmaz
    Department of Anesthesiology, Dicle University Hospital, Diyarbakir, Turkey
    Acta Anaesthesiol Scand 47:180-4. 2003
    ..was to determine the effects of high-dose propofol on the incidence of fasciculations and myalgia, and to evaluate changes in creatine kinase levels following the administration of succinylcholine in 90 women who underwent laparoscopy.
  40. ncbi Succinylcholine and the open globe: questions unanswered
    Elie Joseph Chidiac
    Anesthesiology 100:1035-6; author reply 1037. 2004
  41. pmc Is succinylcholine appropriate or obsolete in the intensive care unit?
    L H Booij
    Institute for Anaesthesiology, University Hospital Nijmegen, Sint Radboud, Nijmegen, The Netherlands
    Crit Care 5:245-6. 2001
    ..The adverse effect profile of succinylcholine is such that its use in the ICU must be considered obsolete...
  42. ncbi Masseter muscle rigidity, elevated creatine kinase, and rhabdomyolysis following succinylcholine administration: a case report
    Lynn R Fitzpatrick
    The University of Iowa Hospitals and Clinics, Iowa City, USA
    AANA J 76:349-54. 2008
    ..rigidity, elevated creatine kinase levels, and rhabdomyolysis following a sevoflurane mask induction and succinylcholine administration in a 12-year-old boy...
  43. ncbi Screening patients with prolonged neuromuscular blockade after succinylcholine and mivacurium
    Charles Cerf
    Department of Anesthesia and Intensive Care Unit, Henri Mondor Hospital, AP HP, Creteil, France
    Anesth Analg 94:461-6, table of contents. 2002
    ..pseudocholinesterase (BChE) variants may exhibit markedly prolonged paralysis after the administration of succinylcholine or mivacurium...
  44. ncbi Prevention of succinylcholine-induced fasciculation and myalgia: a meta-analysis of randomized trials
    Jan Uwe Schreiber
    Department of Anesthesiology and Critical Care Medicine, University Hospital of the Saarland, Homburg, Germany
    Anesthesiology 103:877-84. 2005
    ..5) with muscle relaxants. There was evidence of less myalgia with 1.5 mg/kg succinylcholine (compared with 1 mg/kg). Opioids had no impact...
  45. ncbi Succinylcholine-induced hyperkalemia in acquired pathologic states: etiologic factors and molecular mechanisms
    J A Jeevendra Martyn
    Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 104:158-69. 2006
    Lethal hyperkalemic response to succinylcholine continues to be reported, but the molecular mechanisms for the hyperkalemia have not been completely elucidated...
  46. ncbi Succinylcholine-induced masseter muscle rigidity associated with rapid sequence intubation
    Christopher S Roman
    Department of Emergency Medicine, Carl R Darnall Army Medical Center, Fort Hood TX 76544, USA
    Am J Emerg Med 25:102-4. 2007
  47. ncbi Propofol reduces succinylcholine induced increase of masseter muscle tone
    W C Ummenhofer
    Department of Anaesthesia, University of Basel, Kantonsspital, Switzerland
    Can J Anaesth 45:417-23. 1998
    b>Succinylcholine is known to increase the tone of the masseter muscles...
  48. ncbi The neuromuscular effects and tracheal intubation conditions after small doses of succinylcholine
    Mohammad I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, 836 W Wellington Avenue, Chicago, IL 60657, USA
    Anesth Analg 98:1680-5, table of contents. 2004
    b>Succinylcholine 1.0 mg/kg usually produces excellent tracheal intubation conditions in 60 s...
  49. ncbi Intraocular pressure changes during rapid sequence induction and intubation: a comparison of rocuronium, atracurium, and succinylcholine
    H R Vinik
    Department of Anesthesiology, University of Alabama Birmingham 35233, USA
    J Clin Anesth 11:95-100. 1999
    To compare changes in intraocular pressure (IOP) during rapid sequence induction and intubation following rocuronium, succinylcholine, and atracurium.
  50. ncbi Butyrylcholinesterase (BCHE) genotyping for post-succinylcholine apnea in an Australian population
    Tina Yen
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Missenden Road, Camperdown, Sydney, NSW 2050, Australia
    Clin Chem 49:1297-308. 2003
    ..activity and inhibitor-based phenotyping are standard methods for identifying patients who experience post-succinylcholine (SC) apnea attributable to inherited variants of the BChE enzyme...
  51. pmc Succinylcholine versus rocuronium for rapid sequence intubation in intensive care: a prospective, randomized controlled trial
    Stephan C Marsch
    Department of Medical Intensive Care, University Hospital Basel, University of Basel, Petersgraben 4, Basel 4031, Switzerland
    Crit Care 15:R199. 2011
    b>Succinylcholine and rocuronium are widely used to facilitate rapid sequence induction (RSI) intubation in intensive care...
  52. ncbi Butyrylcholinesterase gene mutations in patients with prolonged apnea after succinylcholine for electroconvulsive therapy
    H M Mollerup
    Danish Cholinesterase Research Unit, Department of Anaesthesiology, Copenhagen University Hospital, Herlev Hospital, Herlev, Denmark
    Acta Anaesthesiol Scand 55:82-6. 2011
    patients undergoing electroconvulsive therapy (ECT) often receive succinylcholine as part of the anesthetic procedure...
  53. ncbi Trachlight management of succinylcholine-induced subluxation of the Temporo-mandibular joint: a case report and review of the literature
    Amanda Roze Des Ordons
    Department of Anesthesiology and Pain Medicine, University of Alberta Hospital, Edmonton, Alberta T6G2B7, Canada
    Can J Anaesth 55:616-21. 2008
    We present a case of spontaneous subluxation of the Temporo-mandibular joint (TMJ) induced by succinylcholine, to compare our experience with previous cases reported in the literature, and to review the pathophysiology, preoperative ..
  54. ncbi Succinylcholine dosage and apnea-induced hemoglobin desaturation in patients
    Mohamed Naguib
    Department of Anesthesia, King Saud University, Riyadh, Saudi Arabia
    Anesthesiology 102:35-40. 2005
    The authors examined the notion that a reduction in succinylcholine dose from 1 mg/kg to approximately 0...
  55. ncbi Genotyping the butyrylcholinesterase in patients with prolonged neuromuscular block after succinylcholine
    Soledad Levano
    Department of Anesthesia, University of Basel, Switzerland
    Anesthesiology 102:531-5. 2005
    b>Succinylcholine remains the standard neuromuscular blocking drug for tracheal intubation in emergency situations. The short duration of action is due to its rapid hydrolytic degradation by butyrylcholinesterase (plasmacholinesterase)...
  56. ncbi [Tako-Tsubo syndrome after anaphylaxis caused by succinylcholine during general anaesthesia]
    J Cabaton
    Service d Anesthesie Reanimation, Centre Hospitalier Lyon Sud, chemin du Petit Revoyer, 69495 Pierre Benite Cedex, France
    Ann Fr Anesth Reanim 27:854-7. 2008
    ..We report here a case of Tako-Tsubo syndrome related to an anaphylactic shock caused by succinylcholine during general anaesthesia of a female patient, wearing an unadjustable gastric band.
  57. ncbi The effect of thiopentone on severity and duration of succinylcholine-induced fasciculation
    Mehrdad Shoroghi
    Department of Anesthesia, Farabi Hospital, Medical Sciences University of Tehran, Tehran
    Clin Neuropharmacol 32:94-6. 2009
    Thiopentone has a protective effect as far as succinylcholine-induced myalgias are concerned; however, a few studies were done in the efficacy of thiopentone on fasciculation induced by succinylcholine...
  58. ncbi Airway injury with low-dose rocuronium versus succinylcholine for rapid-sequence induction: relevance and ethics
    David B Wax
    Anesth Analg 104:210; author reply 210. 2007
  59. ncbi Effect of dexmedetomidine premedication on the intraocular pressure changes after succinylcholine and intubation
    H A Mowafi
    Department of Anaesthesiology, Faculty of Medicine, King Faisal University, Saudi Arabia
    Br J Anaesth 100:485-9. 2008
    b>Succinylcholine is still recommended for some situations in open globe injuries. However, the use of succinylcholine is associated with an increase in intraocular pressure (IOP). This may be deleterious in open globe injuries...
  60. ncbi How much are patients willing to pay to avoid postoperative muscle pain associated with succinylcholine?
    Terrence K Allen
    Department of Anesthesiology, Duke University Medical Center, Box 3094, Durham, NC 27710, USA
    J Clin Anesth 19:601-8. 2007
    To determine how much money patients are willing to pay to avoid postoperative muscle pains associated with succinylcholine.
  61. ncbi Rocuronium versus succinylcholine for rapid sequence induction of anesthesia and endotracheal intubation: a prospective, randomized trial in emergent cases
    Mathias Sluga
    Department of Anesthesia, Krankenhaus Thusis, Switzerland
    Anesth Analg 101:1356-61. 2005
    ..is induced with propofol in elective cases, endotracheal intubation conditions are not different between succinylcholine and rocuronium approximately 60 s after the injection of the neuromuscular relaxant...
  62. ncbi Excellent intubating conditions with remifentanil-propofol and either low-dose rocuronium or succinylcholine
    Sahar M Siddik-Sayyid
    Department of Anesthesiology, American University of Beirut Medical Center, P O Box 11 0236, Beirut, Lebanon
    Can J Anaesth 56:483-8. 2009
    ..intubation, the best intubating conditions, and the shortest duration of muscle paralysis are achieved with succinylcholine. During a lidocaine-remifentanil-propofol induction of anesthesia, we compared intubating conditions 90 s ..
  63. ncbi The dose of succinylcholine required for excellent endotracheal intubating conditions
    Mohamed Naguib
    Department of Anesthesiology and Pain Medicine, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
    Anesth Analg 102:151-5. 2006
    In this prospective, randomized, double-blind, placebo-controlled study, we attempted to define the dose of succinylcholine that provides excellent intubation conditions in patients within 60 s during simulated rapid-sequence induction ..
  64. ncbi Masseter spasm after succinylcholine administration
    Michelle Gill
    Department of Emergency Medicine, Loma Linda University School of Medicine, Medical Center, 11234 Anderson Street, PO Bpx 2000, Room A 108, Loma Linda, CA 92354, USA
    J Emerg Med 29:167-71. 2005
    We report the case of a 20-year-old woman who developed masseter spasm after receiving succinylcholine for rapid sequence intubation...
  65. pmc Succinylcholine induced masseter spasm during rapid sequence intubation may require a surgical airway: case report
    S J Bauer
    4th Infantry Division, 2nd Brigade, Surgeon Section, Fort Hood, TX 76544, USA
    Emerg Med J 22:456-8. 2005
  66. ncbi Pretreatment with remifentanil is associated with less succinylcholine-induced fasciculation
    Karim Nasseri
    Department of Anesthesia, Faculty of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran
    Middle East J Anaesthesiol 20:515-9. 2010
    b>Succinylcholine is a popular muscle relaxant and one of its most common side effects is muscle fasciculation...
  67. ncbi [Effect of ephedrine on the intubation conditions using rocuronium versus succinylcholine]
    L Belyamani
    Service d anesthésiologie, hôpital militaire d instruction Mohammed V, Rabat, Maroc
    Ann Fr Anesth Reanim 27:292-6. 2008
    The goal of this study was to determine if ephedrine could improve intubating conditions when it is administered before the muscle relaxant (rocuronium and succinylcholine).
  68. ncbi Hemoglobin desaturation after succinylcholine-induced apnea: a study of the recovery of spontaneous ventilation in healthy volunteers
    T Heier
    Ullevaal University, Norway
    Anesthesiology 94:754-9. 2001
    BACKGROUND: Because of the rapid recovery of neuromuscular function after succinylcholine administration, there is a belief that patients will start breathing sufficiently rapidly to prevent significant oxygen desaturation...
  69. ncbi Succinylcholine-induced acceleration and suppression of electrically evoked acetylcholine release from mouse phrenic nerve-hemidiaphragm muscle preparation
    I Kimura
    Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Japan
    Jpn J Pharmacol 57:397-403. 1991
    ..b>Succinylcholine at a low concentration (1 microM) enhanced evoked [3H]-ACh release, which tended to follow the increase in ..
  70. ncbi Molar potency is predictive of the speed of onset of neuromuscular block for agents of intermediate, short, and ultrashort duration
    A F Kopman
    New York Medical College, New York, USA
    Anesthesiology 90:425-31. 1999
    The times to peak effect of rocuronium, vecuronium, cisatracurium, mivacurium, and succinylcholine were evaluated to confirm that the correlation between potency and onset time observed for long-acting relaxants also held for drugs of ..
  71. ncbi The "intubating dose" of succinylcholine: the effect of decreasing doses on recovery time
    Aaron F Kopman
    Professor of Anesthesiology, New York Medical College, Valhalla, New York, USA
    Anesthesiology 99:1050-4. 2003
    The usually cited "intubation dose" of succinylcholine is 1.0 mg/kg...
  72. ncbi The dose of succinylcholine in morbid obesity
    Harry J M Lemmens
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California, USA
    Anesth Analg 102:438-42. 2006
    The appropriate dose of succinylcholine (SCH) in morbidly obese patients is unknown. We studied 45 morbidly obese (body mass index >40 kg/m2) adults scheduled for gastric bypass surgery...
  73. ncbi Cost identification analysis for succinylcholine
    F Dexter
    Department of Anesthesia, University of Iowa, Iowa City, Iowa 52242, USA
    Anesth Analg 92:693-9. 2001
    The cost of a dose of succinylcholine from society's perspective equals the acquisition cost of the drug plus the cost of its adverse outcomes...
  74. ncbi Succinylcholine: a drug to avoid in bariatric surgery
    Talar Tejirian
    Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Obes Surg 19:534-6. 2009
    b>Succinylcholine is a paralytic agent regularly utilized in anesthesia. There are numerous adverse effects of succinylcholine ranging from mild to fatal; one such effect is succinylcholine myalgia...
  75. ncbi A comparison of intubating conditions in children following induction of anaesthesia with propofol and suxamethonium or propofol and remifentanil
    J M Morgan
    Department of Anaesthesia, Sheffield Children s Hospital, Western Bank, Sheffield S10 2TH, UK
    Anaesthesia 62:135-9. 2007
    ..05). Mean apnoea time was 190 s in group S, and 362 s in group R (p<0.001). Heart rate increased in response to suxamethonium (p<0.01) and both systolic and diastolic blood pressure decreased in the remifentanil group (p<0.01)...
  76. ncbi [Compared effects of etomidate and propofol for anaesthesia during electroconvulsive therapy]
    Lotfi Grati
    Service d Anesthesie Reanimation, centre hospitalo universitaire F Bourguiba, avenue du 1er juin, 5000 Monastir, Tunisie
    Presse Med 34:282-4. 2005
    ..The aim of this study was to assess the quality of the anaesthetic technique applied for ECT by comparing two products: propofol and etomidate...
  77. ncbi Comparative study of intubating conditions at the first minute with suxamethonium, rocuronium and different priming techniques of rocuronium
    J R Ortiz-Gómez
    University Clinic, Department of Anesthesiology and Intensive Care, Navarra, Spain
    Eur J Anaesthesiol 22:263-8. 2005
    ..To evaluate orotracheal intubation conditions after 1 min...
  78. ncbi Aspiration and postictal agitation after electroconvulsive therapy with propofol but no succinylcholine or atropinic agent
    Conrad M Swartz
    J ECT 21:50-1. 2005
  79. ncbi General anesthesia with remifentanil for Cesarean section in a patient with HELLP syndrome
    F Richa
    Department of Anesthesia and Intensive Care, Hotel Dieu de France Hospital, Saint Joseph University, Beirut, Lebanon
    Acta Anaesthesiol Scand 49:418-20. 2005
    ..We report the management of a patient presenting in labor with HELLP syndrome, and describe the successful use of remifentanil as part of the anesthetic technique for her subsequent Cesarean section...
  80. ncbi Comparison of suxamethonium and priming with atracurium for rapid sequence orotracheal intubation in a Nigerian adult population
    A H Yusuf
    Department of Anaesthesia, Lagos University Teaching Hospital, Idi Araba, Lagos, Nigeria
    Niger Postgrad Med J 13:313-8. 2006
    ..To compare suxamethonium with atracurium using the priming principle, for rapid sequence orotracheal intubation assessing onset time, time to successful laryngoscopy and intubation and quality of intubating conditions...
  81. ncbi Is there an ideal approach for rapid-sequence induction in hypertensive patients?
    Zekeriyya Alanoglu
    Ankara University Medical Faculty, Department of Anesthesiology and Reanimation, 06100 Ankara, Turkey
    J Clin Anesth 18:34-40. 2006
    ..To compare 4 different anesthesia induction protocols, in a simulated model of rapid-sequence induction, in controlled hypertensive patients...
  82. ncbi Morbid obesity: a risk factor for maternal mortality
    Olubukola Nafiu
    Int J Obstet Anesth 16:187; author reply 187-8. 2007
  83. ncbi Comparison of rocuronium and suxamethonium for rapid tracheal intubation in children
    Claudia A Y Cheng
    Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, The Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    Paediatr Anaesth 12:140-5. 2002
    ..The purpose of our study was to determine whether a smaller dose of rocuronium than previously reported could provide similar intubating conditions to suxamethonium during rapid-sequence induction of anaesthesia in children...
  84. ncbi Modification of mediators of immune reaction after general anaesthesia
    A Sanchez Palacios
    Unidad de Alergologia, Hospital Universitario Insular de G C Las Palmas, Gran Canaria, Spain
    Allergol Immunopathol (Madr) 32:352-60. 2004
    ..in our setting (Island of Lanzarote) and modifications to immune response mediators using three types of representative myorelaxants (succinylcholine, cisatracurium and vecuronium) in order to predict and prevent adverse reactions.
  85. ncbi [Electroconvulsive therapy in the third trimester of pregnancy: a case report]
    R M Prieto Martin
    Servicio de Anestesiologia y Reanimacion, Hospital Universitario de Salamanca
    Rev Esp Anestesiol Reanim 53:653-6. 2006
    ..During treatments the patient received general anesthesia with propofol and succinylcholine with insertion of a tracheal tube...
  86. ncbi Anaesthesia for caesarean section in a patient with acute generalised pustular psoriasis
    A Samieh-Tucker
    Department of Anaesthesia, Basildon University Hospital, Basildon, Essex, UK
    Int J Obstet Anesth 16:375-8. 2007
    ..The purpose of this article is to delineate the clinical picture of this disease, its treatment, and the effect on the mother and the fetus...
  87. ncbi [Clinical administration of muscle relaxants for intubation]
    R Hofmockel
    ,
    Anaesthesiol Reanim 26:116-22. 2001
    ..We compare the advantages and disadvantages of succinylcholine (the only depolarising agent) with those of short- and intermediate-acting non-depolarising agents in an ..
  88. ncbi Succinylcholine or rocuronium? A meta-analysis of the effects on intubation conditions
    O Karcioglu
    Department of Emergency Medicine, Dokuz Eylul University School of Medicine, Izmir, Turkey
    Int J Clin Pract 60:1638-46. 2006
    This meta-analysis was undertaken to compare the effects of succinylcholine (SCH) and rocuronium (RCR) on endotracheal intubation (ETI) conditions...
  89. ncbi Rocuronium versus succinylcholine for rapid tracheal intubation
    Aaron F Kopman
    Anesth Analg 102:1912; author reply 1912-3. 2006
  90. ncbi Suxamethonium administration prolongs the duration of action of subsequent rocuronium
    E N Robertson
    University Medical Center, Department of Anesthesiology, Nijmegen, The Netherlands
    Eur J Anaesthesiol 21:734-7. 2004
    ..The neuromuscular effects of suxamethonium and rocuronium, and their effects on intraocular pressure (IOP), heart rate (HR) and arterial pressure were also recorded...
  91. ncbi Adverse effects of neuromuscular blocking agents based on yellow card reporting in the U.K.: are there differences between males and females?
    Karen Patricia Light
    Magill Department of Anaesthesia, Chelsea and Westminster Hospital, London, UK
    Pharmacoepidemiol Drug Saf 15:151-60. 2006
    ..K. such ADRs may be reported through the Yellow Card Scheme (YCS). Our aim was to determine the demographics of ADRs to neuromuscular blocking drugs without formal causality assessment...
  92. ncbi Effects of landiolol on hemodynamic response and seizure duration during electroconvulsive therapy
    Koichi Nomoto
    Department of Anesthesiology, Showa University Northern Yokohama Hospital, 35 1 Chigasaki chuo, Yokohama 224 8503, Japan
    J Anesth 20:183-7. 2006
    ..This study was done to evaluate the effect of landiolol, an ultra-short-acting beta-blocker, on the hemodynamic response and the duration of seizure activity during electroconvulsive therapy (ECT)...
  93. ncbi Which muscle relaxants should be used in day surgery and when
    Gabriella Bettelli
    Department of Anaesthesia and Intensive Care, University of Modena and Reggio Emilia, Policlinico Hospital, Modena, Italy
    Curr Opin Anaesthesiol 19:600-5. 2006
    ..Agent selection criteria are discussed...
  94. ncbi Intubation conditions after rocuronium or succinylcholine for rapid sequence induction with alfentanil and propofol in the emergency patient
    P B Larsen
    University of Copenhagen, Department of Anaesthesiology, Herlev Hospital, Glostrup, Denmark
    Eur J Anaesthesiol 22:748-53. 2005
    ..9-1.2 mg kg[-1] rocuronium to obtain comparable intubation conditions with succinylcholine 1.0 mg kg[-1] after 60 s during a rapid-sequence induction...
  95. ncbi Succinylcholine vs rocuronium for intubation in the intensive care unit
    Kathryn Regan
    National Hospital for Neurology and Neurosurgery, London WC1N 3BG
    Br J Hosp Med (Lond) 66:548. 2005
  96. ncbi Lidocaine or diazepam can decrease fasciculation induced by succinylcholine during induction of anesthesia
    Mansour Hassani
    Tehran University of Medical Sciences, Hassan Abad Square, Sina Hospital, Tehran, Iran
    Middle East J Anaesthesiol 18:929-31. 2006
    b>Succinylcholine is used during induction of anesthesia, and it may induce fasciculations. In this study we demonstrated that intravenous diazepam (1 mg/kg) or lidocaine (1.5 mg/kg) can decrease fasciculations induced by succinylcholine...
  97. ncbi Use of remifentanil for tracheal intubation for caesarean section in a patient with suxamethonium apnoea
    R Alexander
    Department of Anaesthetics, Worcestershire Royal Hospital, Charles Hastings Way, Worcester WR5 1DD, UK
    Anaesthesia 60:1036-8. 2005
    ..The parturient awoke following an uneventful caesarean section with excellent pain relief and no recall. The baby had normal Apgar scores and umbilical blood gas measurements...
  98. ncbi Tracheal intubating conditions and apnoea time after small-dose succinylcholine are not modified by the choice of induction agent
    M I El-Orbany
    Department of Anesthesiology, Advocate Illinois Masonic Medical Center, Chicago, IL 60657, USA
    Br J Anaesth 95:710-4. 2005
    ..v. induction drugs on tracheal intubation conditions and apnoea time after small-dose (0.6 mg kg(-1)) succinylcholine used to facilitate orotracheal intubation at an urban, university-affiliated community medical centre.
  99. ncbi Effects of remifentanil and alfentanil on seizure duration, stimulus amplitudes and recovery parameters during ECT
    Z N Akcaboy
    Department of Anesthesiology, Ankara Numune Hospital, Ankara, Turkey
    Acta Anaesthesiol Scand 49:1068-71. 2005
    ..The goal of this study was to evaluate and compare effects of alfentanil and remifentanil on seizure duration, recovery parameters and degree of stimulus amplitude in patients undergoing electroconvulsive therapy...
  100. ncbi Effectiveness of continuous positive airway pressure to enhance pre-oxygenation in morbidly obese women
    D M Cressey
    Anaesthesia, Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital, Sheffield S10 2JF, UK
    Anaesthesia 56:680-4. 2001
    ..a prospective, open, randomised trial, we measured the time taken to desaturate to 90% from time of giving a succinylcholine bolus as part of a rapid induction of anaesthesia...
  101. ncbi Skin reactions to intradermal neuromuscular blocking agent injections: a randomized multicenter trial in healthy volunteers
    Paul Michel Mertes
    Department of Anesthesiology, Service d Anesthesie Reanimation, Hopital Central, Centre Hospitalier Universitaire de Nancy, Unité Inserm 684, Faculte de Medecine de Nancy, France
    Anesthesiology 107:245-52. 2007
    ..Numerous reports confirm the performance of intradermal tests for the diagnosis of anaphylaxis during anesthesia; however, there is controversy over their diagnostic value regarding the newer neuromuscular blocking agents (NMBAs)...

Research Grants10

  1. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  2. ALPHA-CONOPEPTIDES: NOVEL RAPID-ACTING MUSCLE RELAXANTS
    RICHARD LAYER; Fiscal Year: 2000
    ..Currently, succinylcholine is the only muscle relaxant with the requisite profile of rapid onset and short duration suitable for ..
  3. RAPID DETOXIFICATION OF COCAINE BY BUTYRYLCHOLINESTERASE
    Oksana Lockridge; Fiscal Year: 2000
    ..standard dose of cocaine as if it were an overdose, similar to their abnormal response to the muscle relaxant succinylcholine. To test this hypothesis, it is proposed to genotype the butyryl cholinesterase of people who have died after ..
  4. NON-INVASIVE DIAGNOSIS FOR MALIGNANT HYPERTHERMIA
    S Ohnishi; Fiscal Year: 1990
    ..a susceptible individual with virtually any potent inhalational agent (most commonly with halothane) and/or succinylcholine (a widely used muscle relaxant) in the operating room...
  5. ENZYME THERAPY FOR SURGERY-RELATED APNEA
    RICHARD COUCH; Fiscal Year: 1993
    ..plasma butyrycholinesterase and will evaluate this enzyme's potential therapeutic value for inactivating both succinylcholine and mivacurium...
  6. COCAINE DETOXIFICATION BY BUTYRYLCHOLINESTERASE
    Thomas Lynch; Fiscal Year: 1991
    ..This population is sensitive to succinylcholine, a muscle relaxant commonly used in surgical anaesthesia...
  7. Mass Spectrometry in Clinical Diagnosis of Nerve Agent Exposure
    Oksana Lockridge; Fiscal Year: 2008
    ..The new diagnostic methods have the potential for saving lives in an emergency because correct, rapid diagnosis indicates the appropriate medical treatment. [unreadable] [unreadable] [unreadable]..
  8. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    Samuel Cartner; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  9. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    Samuel Cartner; Fiscal Year: 2008
    ..The requested equipment will be a part of the infrastructure needed to maintain and support the growth of a nationally and internationally recognized interdisciplinary research program. [unreadable] [unreadable] [unreadable]..