choline

Summary

Summary: A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism.

Top Publications

  1. pmc Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    Ya Wen Teng
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:36258-67. 2011
  2. pmc Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet
    Gaetano Serviddio
    Centre For The Study of Liver Diseases, Institute of Internal Medicine, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    PLoS ONE 6:e24084. 2011
  3. pmc Importance of methyl donors during reproduction
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 89:673S-7S. 2009
  4. ncbi Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    J Nutr 132:2333S-2335S. 2002
  5. pmc Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    Smaranda Craciun
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:21307-12. 2012
  6. pmc Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
    Miriam Moscoso
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Bacteriol 188:7785-95. 2006
  7. pmc Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain
    Jessica M Davison
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:1982-9. 2009
  8. pmc Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione
    Francisco Caballero
    Liver Unit, Centro de Investigaciones Biomédicas Esther Koplowitz, Instituto Malalties Digestivas i Metaboliques, Hospital Clinic i Provincial, 08036 Barcelona, Spain
    J Biol Chem 285:18528-36. 2010
  9. doi Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans
    Xinyin Jiang
    Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA
    FASEB J 26:3563-74. 2012
  10. ncbi Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan
    Warren H Meck
    Department of Psychological and Brain Sciences, Duke University, 9 Flowers Drive, Box 90086, Durham, NC 27708 0086, USA
    Neurosci Biobehav Rev 27:385-99. 2003

Detail Information

Publications389 found, 100 shown here

  1. pmc Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
    Ya Wen Teng
    Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 286:36258-67. 2011
    ..01). These mice had lower concentrations of choline, phosphocholine, glycerophosphocholine, phosphatidylcholine, and sphingomyelin in several tissues...
  2. pmc Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet
    Gaetano Serviddio
    Centre For The Study of Liver Diseases, Institute of Internal Medicine, Department of Medical and Occupational Sciences, University of Foggia, Foggia, Italy
    PLoS ONE 6:e24084. 2011
    ..A high fat/methionine-choline deficient (MCD) diet, administered for 4 weeks, was used to induce NASH in rats...
  3. pmc Importance of methyl donors during reproduction
    Steven H Zeisel
    Nutrition Research Institute, Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Clin Nutr 89:673S-7S. 2009
    Evidence is growing that optimal dietary intake of folate and choline (both involved in one-carbon transfer or methylation) is important for successful completion of fetal development...
  4. ncbi Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline
    Mihai D Niculescu
    Department of Nutrition, School of Public Health, School of Medicine, University of North Carolina, Chapel Hill 27599 7400, USA
    J Nutr 132:2333S-2335S. 2002
    ..Dietary methyl groups derive from foods that contain methionine, one-carbon units and choline (or the choline metabolite betaine)...
  5. pmc Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme
    Smaranda Craciun
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 109:21307-12. 2012
    b>Choline and trimethylamine (TMA) are small molecules that play central roles in biological processes throughout all kingdoms of life...
  6. pmc Biofilm formation by Streptococcus pneumoniae: role of choline, extracellular DNA, and capsular polysaccharide in microbial accretion
    Miriam Moscoso
    Departamento de Microbiologia Molecular, Centro de Investigaciones Biologicas, CSIC, Ramiro de Maeztu 9, 28040 Madrid, Spain
    J Bacteriol 188:7785-95. 2006
    ..b>Choline residues of cell wall teichoic acids were found to play a fundamental role in pneumococcal biofilm development...
  7. pmc Gestational choline supply regulates methylation of histone H3, expression of histone methyltransferases G9a (Kmt1c) and Suv39h1 (Kmt1a), and DNA methylation of their genes in rat fetal liver and brain
    Jessica M Davison
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 284:1982-9. 2009
    b>Choline is an essential nutrient that, via its metabolite betaine, serves as a donor of methyl groups used in fetal development to establish the epigenetic DNA and histone methylation patterns...
  8. pmc Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione
    Francisco Caballero
    Liver Unit, Centro de Investigaciones Biomédicas Esther Koplowitz, Instituto Malalties Digestivas i Metaboliques, Hospital Clinic i Provincial, 08036 Barcelona, Spain
    J Biol Chem 285:18528-36. 2010
    ..Feeding a diet deficient in both methionine and choline (MCD) is one of the most common models of NASH, which is characterized by steatosis, mitochondrial dysfunction, ..
  9. doi Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans
    Xinyin Jiang
    Division of Nutritional Sciences and Genomics, Cornell University, Ithaca, NY 14853, USA
    FASEB J 26:3563-74. 2012
    The in utero availability of methyl donors, such as choline, may modify fetal epigenetic marks and lead to sustainable functional alterations throughout the life course...
  10. ncbi Metabolic imprinting of choline by its availability during gestation: implications for memory and attentional processing across the lifespan
    Warren H Meck
    Department of Psychological and Brain Sciences, Duke University, 9 Flowers Drive, Box 90086, Durham, NC 27708 0086, USA
    Neurosci Biobehav Rev 27:385-99. 2003
    A growing body of research supports the view that choline is an essential nutrient during early development that has long-lasting effects on memory and attentional processes throughout the lifespan...
  11. pmc Dietary choline deficiency alters global and gene-specific DNA methylation in the developing hippocampus of mouse fetal brains
    Mihai D Niculescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, North Carolina, 27599 7461 USA
    FASEB J 20:43-9. 2006
    The availability of choline during critical periods of fetal development alters hippocampal development and affects memory function throughout life...
  12. pmc Prostate cancer: PET with 18F-FDG, 18F- or 11C-acetate, and 18F- or 11C-choline
    Hossein Jadvar
    Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 52:81-9. 2011
    ..In this article, I review the preclinical and clinical evidence on the potential and emerging role of PET with the 3 most commonly studied radiotracers in prostate cancer, namely 18F-FDG, 18F- or 11C-acetate, and 18F- or 11C-choline.
  13. doi Choline and betaine in health and disease
    Per Magne Ueland
    Section for Pharmacology, Institute of Medicine, University of Bergen, Bergen, Norway
    J Inherit Metab Dis 34:3-15. 2011
    b>Choline is an essential nutrient, but is also formed by de novo synthesis. Choline and its derivatives serve as components of structural lipoproteins, blood and membrane lipids, and as a precursor of the neurotransmitter acetylcholine...
  14. ncbi Glioma grading: sensitivity, specificity, and predictive values of perfusion MR imaging and proton MR spectroscopic imaging compared with conventional MR imaging
    Meng Law
    Department of Radiology, New York University Medical Center, NY, USA
    AJNR Am J Neuroradiol 24:1989-98. 2003
    ..We evaluated the sensitivity, specificity, PPV, and NPV of perfusion MR imaging and MR spectroscopy compared with conventional MR imaging in grading primary gliomas...
  15. doi First results of [11C]choline PET/CT-guided secondary lymph node surgery in patients with PSA failure and single lymph node recurrence after radical retropubic prostatectomy
    Alexander Winter
    Department of Urology and Paediatric Urology, Hospital Oldenburg, Oldenburg, Germany winter alexander klinikum oldenburg de
    Urol Int 84:418-23. 2010
    11)C]choline PET/CT provides the opportunity to detect small lymph node metastases (LNM) (>5 mm) in prostate cancer (PCa) with exact topographic allocation...
  16. doi Pelvic/retroperitoneal salvage lymph node dissection for patients treated with radical prostatectomy with biochemical recurrence and nodal recurrence detected by [11C]choline positron emission tomography/computed tomography
    Patrizio Rigatti
    Department of Urology, Urological Research Institute, University Vita Salute San Raffaele, Milan, Italy
    Eur Urol 60:935-43. 2011
    ..The management of patients with clinical recurrence of prostate cancer after radical prostatectomy (RP) remains challenging...
  17. doi The ATP-binding cassette transporter Cbc (choline/betaine/carnitine) recruits multiple substrate-binding proteins with strong specificity for distinct quaternary ammonium compounds
    Chiliang Chen
    Department of Plant Pathology, Iowa State University, Ames, IA 50011, USA
    Mol Microbiol 75:29-45. 2010
    We identified a choline, betaine and carnitine transporter, designated Cbc, from Pseudomonas syringae and Pseudomonas aeruginosa that is unusual among members of the ATP-binding cassette (ABC) transporter family in its use of multiple ..
  18. pmc Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression
    Karen D Corbin
    University of North Carolina at Chapel Hill, Nutrition Research Institute, Kannapolis, North Carolina, USA
    Curr Opin Gastroenterol 28:159-65. 2012
    b>Choline is an essential nutrient and the liver is a central organ responsible for choline metabolism. Hepatosteatosis and liver cell death occur when humans are deprived of choline...
  19. pmc Age-related declines in exploratory behavior and markers of hippocampal plasticity are attenuated by prenatal choline supplementation in rats
    Melissa J Glenn
    Psychology and Neuroscience, Duke University, Durham, NC, USA
    Brain Res 1237:110-23. 2008
    Supplemental choline in the maternal diet produces a lasting enhancement in memory in offspring that resists age-related decline and is accompanied by neuroanatomical, neurophysiological and neurochemical changes in the hippocampus...
  20. doi Prostate cancer: 1HMRS-DCEMR at 3T versus [(18)F]choline PET/CT in the detection of local prostate cancer recurrence in men with biochemical progression after radical retropubic prostatectomy (RRP)
    Valeria Panebianco
    Dept of Radiological Sciences, Sapienza University of Rome, V le Regina Elena, 324 00161 Rome, Italy
    Eur J Radiol 81:700-8. 2012
    ..and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) combined techniques at 3T magnet versus [(18)F]choline PET/computed tomography (CT) in the detection of local prostate cancer recurrence in patients with biochemical ..
  21. doi Folate and choline metabolism gene variants and development of uterine cervical carcinoma
    Adrianna Mostowska
    Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego St, 60 781 Poznan, Poland
    Clin Biochem 44:596-600. 2011
    ..The aim of this study was to evaluate the possibility that polymorphic variants of genes that may affect DNA methylation status are associated with the risk of cervical cancer in the Polish population...
  22. pmc Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans
    Martin Kohlmeier
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    Proc Natl Acad Sci U S A 102:16025-30. 2005
    b>Choline is a required nutrient, and some humans deplete quickly when fed a low-choline diet, whereas others do not...
  23. pmc Choline availability during embryonic development alters progenitor cell mitosis in developing mouse hippocampus
    Corneliu N Craciunescu
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    J Nutr 133:3614-8. 2003
    Previously, we reported that dietary choline influences development of the hippocampus in fetal rat brain...
  24. pmc Deletion of murine choline dehydrogenase results in diminished sperm motility
    Amy R Johnson
    Department of Nutrition, Nutrition Research Institute, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    FASEB J 24:2752-61. 2010
    b>Choline dehydrogenase (CHDH) catalyzes the conversion of choline to betaine, an important methyl donor and organic osmolyte...
  25. ncbi In vivo quantification of choline compounds in the breast with 1H MR spectroscopy
    Patrick J Bolan
    Center for Magnetic Resonance Research, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 50:1134-43. 2003
    This work describes a methodology for quantifying levels of total choline-containing compounds (tCho) in the breast using in vivo (1)H MR spectroscopy (MRS) at high field (4 Tesla)...
  26. doi Phosphatidylcholine and choline homeostasis
    Zhaoyu Li
    Department of Biochemistry and the Group on the Molecular and Cell Biology of Lipids, University of Alberta, Edmonton, Alberta T6G 2S2, Canada
    J Lipid Res 49:1187-94. 2008
    Phosphatidylcholine (PC) is made in mammalian cells from choline via the CDP-choline pathway. Animals obtain choline primarily from the diet or from the conversion of phosphatidylethanolamine (PE) to PC followed by catabolism to choline...
  27. pmc Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling
    William R Parrish
    Laboratory of Biomedical Science, The Feinstein Institute for Medical Research, North Shore LIJ Health System, Manhasset, New York 11030, USA
    Mol Med 14:567-74. 2008
    ..b>Choline is an essential nutrient, a cell membrane constituent, a precursor in the biosynthesis of acetylcholine, and a ..
  28. pmc 1H MR spectroscopy in common dementias
    K Kantarci
    Department of Diagnostic Radiology, Mayo Clinic 200 First St SW, Rochester, MN 55905, USA
    Neurology 63:1393-8. 2004
    ..To determine the 1H MR spectroscopic (MRS) findings and intergroup differences among common dementias: Alzheimer disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD)...
  29. ncbi Concentrations of choline-containing compounds and betaine in common foods
    Steven H Zeisel
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7461, USA
    J Nutr 133:1302-7. 2003
    b>Choline is important for normal membrane function, acetylcholine synthesis and methyl group metabolism; the choline requirement for humans is 550 mg/d for men (Adequate Intake)...
  30. pmc Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline
    Wei Sha
    Bioinformatics Research Center, University of North Carolina at Charlotte, USA
    FASEB J 24:2962-75. 2010
    b>Choline is an essential nutrient, and deficiency causes liver and muscle dysfunction...
  31. pmc Evaluation of total choline from in-vivo volume localized proton MR spectroscopy and its response to neoadjuvant chemotherapy in locally advanced breast cancer
    N R Jagannathan
    Department of NMR, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Br J Cancer 84:1016-22. 2001
    ..2 ppm due to choline containing compounds (TCho) before treatment...
  32. ncbi Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry
    Pal I Holm
    LOCUS for Homocysteine and Related Vitamins, University of Bergen, N 5021 Bergen, Norway
    Clin Chem 49:286-94. 2003
    The quaternary ammonium compounds, choline and betaine, and dimethylglycine (DMG) reside along a metabolic pathway linked to the synthesis of neurotransmitters and membrane phospholipids and to homocysteine remethylation and, therefore, ..
  33. ncbi Characterization of neoplastic and normal human breast tissues with in vivo (1)H MR spectroscopy
    K A Kvistad
    MR Center, Medical Division, University Hospital, N 7006 Trondheim, Norway
    J Magn Reson Imaging 10:159-64. 1999
    The purpose of this study was to evaluate whether the detection of choline-containing compounds in in vivo (1)H magnetic resonance spectroscopy (MRS) of breast lesions is specific for carcinomas, whether a choline peak in in vivo (1)H ..
  34. pmc Metabolic assessment of the action of targeted cancer therapeutics using magnetic resonance spectroscopy
    M Beloueche-Babari
    Section of Magnetic Resonance, Cancer Research UK and EPSRC Cancer Imaging Centre, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Surrey SM2 5PT, UK
    Br J Cancer 102:1-7. 2010
    ..We describe the MRS-detectable PD biomarkers resulting from the action of targeted therapeutics, and discuss their biological significance and future translation into clinical use...
  35. ncbi The evaluation of human breast lesions with magnetic resonance imaging and proton magnetic resonance spectroscopy
    K M Cecil
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, USA
    Breast Cancer Res Treat 68:45-54. 2001
    ..Cancerous lesions demonstrate elevated composite choline levels arising from increased cellular proliferation...
  36. ncbi Preoperative staging of pelvic lymph nodes in prostate cancer by 11C-choline PET
    Igle J de Jong
    Department of Urology and PET Center, Groningen University Hospital, Groningen, The Netherlands
    J Nucl Med 44:331-5. 2003
    ..The aim of this study was to evaluate the strength and accuracy of (11)C-choline PET in preoperative noninvasive staging of pelvic lymph nodes in prostate cancer.
  37. doi The value of 18F-choline PET/CT in patients with elevated PSA-level and negative prostate needle biopsy for localisation of prostate cancer
    I Igerc
    Department of Nuclear Medicine and Endocrinology, PET CT Center, Klagenfurt, State Hospital Klagenfurt, St Veiterstrasse 47, A 9020 Klagenfurt, Austria
    Eur J Nucl Med Mol Imaging 35:976-83. 2008
    ..with persistent elevated PSA and repeated negative prostate biopsy, that means having the prostate biopsied at multiple times, were investigated with 18F-choline PET/CT to delineate prostate cancer and guide renewed prostate biopsy.
  38. pmc Comparison of PET imaging with a (68)Ga-labelled PSMA ligand and (18)F-choline-based PET/CT for the diagnosis of recurrent prostate cancer
    Ali Afshar-Oromieh
    Department of Nuclear Medicine, University Hospital of Heidelberg, INF 400, 69120, Heidelberg, Germany
    Eur J Nucl Med Mol Imaging 41:11-20. 2014
    Positron emission tomography (PET) with choline tracers has found widespread use for the diagnosis of prostate cancer (PC)...
  39. ncbi Choline uptake into the malaria parasite is energized by the membrane potential
    Adele M Lehane
    School of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, ACT 0200, Australia
    Biochem Biophys Res Commun 320:311-7. 2004
    The uptake by the intraerythrocytic malaria parasite of the phospholipid precursor choline was investigated in parasites 'isolated' from their host cells by saponin permeabilization of the erythrocyte membrane...
  40. ncbi Efficacy of eradicative radiotherapy for limited nodal metastases detected with choline PET scan in prostate cancer patients
    Franco Casamassima
    Clinical Radiobiological Institute, University of Firenze, Italy
    Tumori 97:49-55. 2011
    ..We investigated the capability of stereotactic body radiotherapy to treat limited nodal recurrences, detected using choline PET scan.
  41. pmc Choline analogues in malaria chemotherapy
    Suzanne Peyrottes
    Institut des Biomolecules Max Mousseron, UMR 5247 CNRS UM1 UM2, Universite Montpellier 2, Place E Bataillon, 34095 Montpellier, France
    Curr Pharm Des 18:3454-66. 2012
    ..This review compiles literature concerning the design and study of choline analogues and related cation derivatives as potential anti-malarials...
  42. doi 18F-fluorocholine for prostate cancer imaging: a systematic review of the literature
    G Bauman
    Department of Oncology, The University of Western Ontario, London Health Sciences Centre St Joseph s Healthcare Centre, London, Ontario, Canada
    Prostate Cancer Prostatic Dis 15:45-55. 2012
    ..Altered choline metabolism has been noted as a characteristic of prostate cancer (PCa), and radiolabeled choline and choline ..
  43. doi Choline and betaine intake is inversely associated with breast cancer risk: a two-stage case-control study in China
    Cai Xia Zhang
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat Sen University, Guangzhou, China
    Cancer Sci 104:250-8. 2013
    Few epidemiological studies have evaluated the association of choline and betaine intake with breast cancer risk and the results remain inconsistent...
  44. doi Comparison of integrated whole-body [11C]choline PET/MR with PET/CT in patients with prostate cancer
    Michael Souvatzoglou
    Department of Nuclear Medicine, Technische Universitat Munchen, Ismaningerstr 22, 81675, Munich, Germany
    Eur J Nucl Med Mol Imaging 40:1486-99. 2013
    To evaluate the performance of conventional [(11)C]choline PET/CT in comparison to that of simultaneous whole-body PET/MR.
  45. pmc Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma
    Leslie M Fischer
    Department of Nutrition, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 28081, USA
    Am J Clin Nutr 92:336-46. 2010
    b>Choline is essential for infant nutrition, and breast milk is a rich source of this nutrient. Common single nucleotide polymorphisms (SNPs) change dietary requirements for choline intake.
  46. pmc Phosphatidylcholine and the CDP-choline cycle
    Paolo Fagone
    Department of Hematology, St Jude Children s Research Hospital, Memphis, TN 38105, USA
    Biochim Biophys Acta 1831:523-32. 2013
    The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Investigation of the CDP-choline pathway in yeast provides a basis for understanding the CDP-choline pathway in mammals...
  47. pmc Cellular choline and glycine betaine pools impact osmoprotection and phospholipase C production in Pseudomonas aeruginosa
    Liam F Fitzsimmons
    Department of Microbiology and Molecular Genetics, University of Vermont College of Medicine, Burlington, Vermont, USA
    J Bacteriol 194:4718-26. 2012
    b>Choline is abundantly produced by eukaryotes and plays an important role as a precursor of the osmoprotectant glycine betaine...
  48. ncbi Plasma choline and betaine correlate with serum folate, plasma S-adenosyl-methionine and S-adenosyl-homocysteine in healthy volunteers
    Apolline Imbard
    Biochemistry Hormonology Laboratory, Robert Debre Hospital, 48 Boulevard Serurier, 75019 Paris, France
    Clin Chem Lab Med 51:683-92. 2013
    b>Choline is essential for mammalian cell function. It plays a critical role in cell membrane integrity, neurotransmission, cell signaling and lipid metabolism...
  49. pmc M3 subtype of muscarinic acetylcholine receptor promotes cardioprotection via the suppression of miR-376b-5p
    Zhenyu Pan
    Department of Pharmacology, Key Laboratory of Cardiovascular Research, Ministry of Education, Harbin Medical University, Harbin, Heilongjiang, People s Republic of China
    PLoS ONE 7:e32571. 2012
    ..revealed that miR-376b-5p was significantly up-regulated in ischemic heart tissue and the M(3)-mAChRs agonist choline reversed its up-regulation...
  50. ncbi In vivo spectroscopic quantification of the N-acetyl moiety, creatine, and choline from large volumes of brain gray and white matter: effects of normal aging
    A Pfefferbaum
    Neuropsychiatry Program, Center for Health Sciences, SRI International, Menlo Park, California 94025, USA
    Magn Reson Med 41:276-84. 1999
    ..voxel, was developed and used to estimate the concentration of the N-acetyl-moiety (NAc), creatine (Cr), and choline (Cho) in gray matter and white matter...
  51. ncbi Intestinal ischaemia during cardiac arrest and resuscitation: comparative analysis of extracellular metabolites by microdialysis
    Ulrike Korth
    Faculty of Clinical Medicine Mannheim, Institute of Anesthesiology, University of Heidelberg, 68165 Mannheim, Germany
    Resuscitation 58:209-17. 2003
    ..Plasma levels of glucose, lactate and choline were increased at 15-60 min following cardiac arrest...
  52. doi Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice
    Kanji Yamaguchi
    Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Lab Invest 90:1169-78. 2010
    ..Six-week-old male C57/BL6 mice were fed either chow control or a methionine choline-deficient (MCD) diet for 8 weeks...
  53. pmc Target volume definition in high-risk prostate cancer patients using sentinel node SPECT/CT and 18 F-choline PET/CT
    Hansjorg Vees
    Division of Radiation Oncology, University Hospital, Geneva, Switzerland
    Radiat Oncol 7:134. 2012
    To assess the influence of sentinel lymph nodes (SNs) SPECT/CT and 18 F-choline (18 F-FCH) PET/CT in radiotherapy (RT) treatment planning for prostate cancer patients with a high-risk for lymph node (LN) involvement.
  54. pmc Dose-escalation using intensity-modulated radiotherapy for prostate cancer - evaluation of quality of life with and without (18)F-choline PET-CT detected simultaneous integrated boost
    Michael Pinkawa
    Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
    Radiat Oncol 7:14. 2012
    ..Quality of life after radiotherapy (RT) with vs. without (18)F-choline PET-CT detected simultaneous integrated boost (SIB) was prospectively evaluated in this study.
  55. doi Predictive factors of [(11)C]choline PET/CT in patients with biochemical failure after radical prostatectomy
    Giampiero Giovacchini
    Center for Molecular Bioimaging, University of Milano Bicocca, Milano, Italy
    Eur J Nucl Med Mol Imaging 37:301-9. 2010
    Detection of recurrence in prostate cancer patients with biochemical failure after radical prostatectomy by [(11)C]choline PET/CT depends on the prostate-specific antigen (PSA) level...
  56. pmc N-acetylaspartate, choline, myoinositol, glutamine and glutamate (glx) concentration changes in proton MR spectroscopy (1H MRS) in patients with mild cognitive impairment (MCI)
    Jerzy Walecki
    Department of Radiology, Medical Centre of Postgraduate Education, Warsaw, Poland
    Med Sci Monit 17:MT105-11. 2011
    ..Purpose of study was evaluation of regional metabolic disorders using 1H MRS in patients with MCI, as a predictor of clinical conversion to dementia based on clinical follow-up...
  57. pmc Prenatal ablation of nicotinic receptor alpha7 cell lineages produces lumbosacral spina bifida the severity of which is modified by choline and nicotine exposure
    Scott W Rogers
    Salt Lake City VA Geriatric Research, Education and Clinical Center, Salt Lake City, Utah, USA
    Am J Med Genet A 158:1135-44. 2012
    ..We hypothesized that like humans, this defect would be modified by environmental compounds not only folic acid or choline but also nicotine...
  58. doi Evaluation of the PET component of simultaneous [(18)F]choline PET/MRI in prostate cancer: comparison with [(18)F]choline PET/CT
    Axel Wetter
    Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany
    Eur J Nucl Med Mol Imaging 41:79-88. 2014
    The aim of this study was to evaluate the positron emission tomography (PET) component of [(18)F]choline PET/MRI and compare it with the PET component of [(18)F]choline PET/CT in patients with histologically proven prostate cancer and ..
  59. ncbi 18F-choline images murine atherosclerotic plaques ex vivo
    Christian M Matter
    Cardiovascular Research, Institute of Physiology, University of Zurich, Cardiovascular Center, Switzerland
    Arterioscler Thromb Vasc Biol 26:584-9. 2006
    ..Similarly, enhanced uptake of 18F-fluorocholine (18F-FCH) was associated with macrophages surrounding an abscess. As macrophages are important determinants of plaque vulnerability, we tested 18F-FCH for plaque imaging...
  60. pmc What choline metabolism can tell us about the underlying mechanisms of fetal alcohol spectrum disorders
    Steven H Zeisel
    Department of Nutrition, UNC Nutrition Research Institute at Kannapolis, University of North Carolina at Chapel Hill, 500 Laureate Way, Room 2218, Kannapolis, NC 28081, USA
    Mol Neurobiol 44:185-91. 2011
    ..characteristic of fetal alcohol spectrum disorders (FASD), but if these rat dams were also treated with choline, the effects from ethanol were attenuated in their pups...
  61. pmc The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet
    Matthew Wortham
    Department of Pharmacology, Toxicology, and Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Dig Dis Sci 53:2761-74. 2008
    ..db/db mice spontaneously develop hepatic steatosis, which progresses to NASH when these mice are fed a methionine choline-deficient (MCD) diet...
  62. ncbi Effect of oral intake of choline-stabilized orthosilicic acid on skin, nails and hair in women with photodamaged skin
    A Barel
    Faculty of Physical Education and Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium
    Arch Dermatol Res 297:147-53. 2005
    ..Silicon (Si) was suggested to have an important function in the formation and maintenance of connective tissue. Choline-stabilized orthosilicic acid ("ch-OSA") is a bioavailable form of silicon which was found to increase ..
  63. doi Prenatal choline supplementation in rats increases the expression of IGF2 and its receptor IGF2R and enhances IGF2-induced acetylcholine release in hippocampus and frontal cortex
    Isabella Napoli
    Department of Pathology and Laboratory Medicine, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Brain Res 1237:124-35. 2008
    b>Choline is an essential nutrient whose availability during the second half of gestation produces long-lasting cognitive effects...
  64. doi Simultaneous 18F choline positron emission tomography/magnetic resonance imaging of the prostate: initial results
    Axel Wetter
    Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Hufelandstrasse 55, 45147 Essen, Germany
    Invest Radiol 48:256-62. 2013
    The purposes of this study were to evaluate the feasibility of simultaneous 18F choline positron emission tomography (PET) and magnetic resonance imaging (MRI) of the prostate and to present the first clinical results of the method.
  65. ncbi Low choline concentrations in normal-appearing white matter of patients with multiple sclerosis and normal MR imaging brain scans
    M C Gustafsson
    Division of Neurology, Department of Radiation Physics, University Hospital, Linkoping, Sweden
    AJNR Am J Neuroradiol 28:1306-12. 2007
    ....
  66. ncbi Choline produces cytoprotective effects against ischemic myocardial injuries: evidence for the role of cardiac m3 subtype muscarinic acetylcholine receptors
    Baofeng Yang
    Department of Pharmacology, State Province Key Laboratory, Harbin Medical University, Harbin, Canada
    Cell Physiol Biochem 16:163-74. 2005
    ..This study was designed to explore the possible role of M(3)-mAChR in cytoprotection of myocardial infarction and several related signaling pathways as potential mechanisms...
  67. pmc Regional gray and white matter metabolite differences in subjects with AD, with subcortical ischemic vascular dementia, and elderly controls with 1H magnetic resonance spectroscopic imaging
    S Mackay
    Magnetic Resonance Spectroscopy Unit, Department of Veterans Affairs Medical Center, San Francisco, USA
    Arch Neurol 53:167-74. 1996
    ..imaging to study differences in neuron density (N-acetylaspartate [NAA]), membrane phospholipid metabolites (choline [Cho]), and creatine-containing metabolites (creatine plus phosphocreatine [Cr]) in subjects with Alzheimer's ..
  68. doi In vivo proton MR spectroscopy of the breast using the total choline peak integral as a marker of malignancy
    Francesco Sardanelli
    University of Milan School of Medicine, Department of Medical and Surgical Sciences, IRCCS Policlinico San Donato, Milan, Italy
    AJR Am J Roentgenol 192:1608-17. 2009
    The purpose of our study was to use the total choline-containing compound (tCho) peak integral as a marker of malignancy in breast MR spectroscopy (MRS).
  69. pmc Detection of aggressive primary prostate cancer with 11C-choline PET/CT using multimodality fusion techniques
    Morand Piert
    Department of Radiology, University of Michigan, Ann Arbor, Michigan 48109 0028, USA
    J Nucl Med 50:1585-93. 2009
    The aim of the study was to assess whether (11)C-choline PET/CT could identify high-risk primary adenocarcinoma of the prostate.
  70. pmc Clinical characteristics and biomarkers of breast cancer associated with choline concentration measured by 1H MRS
    J H Chen
    Tu and Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697, USA
    NMR Biomed 24:316-24. 2011
    This study investigated the association between the total choline (tCho) concentration and the clinical characteristics and biomarker status of breast cancer. Sixty-two patients with breast cancer, 1...
  71. pmc The supply of choline is important for fetal progenitor cells
    Steven H Zeisel
    Nutrition Research Institute, School of Public Health and School of Medicine, The University of North Carolina at Chapel Hill, Kannapolis, NC 28081, United States
    Semin Cell Dev Biol 22:624-8. 2011
    ..b>Choline is needed by these cells for membrane synthesis and for methylation...
  72. ncbi Use of MR spectroscopy and functional imaging in the treatment planning of gliomas
    A Narayana
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, Weill Medical College of Cornell University, 1275 York Avenue, New York, NY 10021, USA
    Br J Radiol 80:347-54. 2007
    ..12 patients with gliomas underwent multivoxel MRS and functional imaging using GE processing software. The choline to creatine ratio (Cho:Cr), which represents the degree of abnormality for each individual voxel on MRSI, was ..
  73. ncbi Postnatal dietary choline supplementation alters behavior in a mouse model of Rett syndrome
    Nupur Nag
    Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA
    Neurobiol Dis 26:473-80. 2007
    ..In rodents, increased choline availability during development enhances transmission at cholinergic synapses and improves behavioral performance ..
  74. ncbi Reexamining the role of choline transporter-like (Ctlp) proteins in choline transport
    Rachel Zufferey
    Center for Microbial Pathogenesis, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, Connecticut, USA
    Neurochem Res 29:461-7. 2004
    In Saccharomyces cerevisiae, choline enters the cell via a single high-affinity transporter, Hnmlp. hnm1delta cells lacking HNM1 gene are viable...
  75. pmc Correlation of phospholipid metabolites with prostate cancer pathologic grade, proliferative status and surgical stage - impact of tissue environment
    K R Keshari
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA
    NMR Biomed 24:691-9. 2011
    ..cohort of surgical patients with clinical outcome data, but support the role of in vivo (1)H MRSI in discriminating between low- and high-grade prostate cancer based on the magnitude of elevation of the in vivo total choline resonance.
  76. doi Choline produces antiarrhythmic actions in animal models by cardiac M3 receptors: improvement of intracellular Ca2+ handling as a common mechanism
    Yan Liu
    Department of Pharmacology, Harbin Medical University, Baojian Road 157, Harbin, Heilongjiang 150081, PR China
    Can J Physiol Pharmacol 86:860-5. 2008
    It is well known that choline has protective effects on ischemic arrhythmias...
  77. doi Neurochemical changes in a mouse model of Rett syndrome: changes over time and in response to perinatal choline nutritional supplementation
    BONNIE C WARD
    Department of Biological Sciences, Wellesley College, Wellesley, MA 02481, USA
    J Neurochem 108:361-71. 2009
    ..Previously, we have shown that early postnatal choline (Cho) supplementation improves behavioral and neuroanatomical symptoms in a mouse model of RTT (Mecp2(1lox) mice)...
  78. ncbi Overexpression of phospholipase D1 in human breast cancer tissues
    D Y Noh
    Department of Surgery, College of Medicine, Seoul National University, 28 Yongon Dong, Jongno gu, 110 744, Seoul, South Korea
    Cancer Lett 161:207-14. 2000
    Phospholipase D (PLD) catalyzes the hydrolysis of phosphatidylcholine (PC) to produce phosphatidic acid (PA) and choline. PLD is a major enzyme implicated in important cellular processes, such as cell proliferation...
  79. doi Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer
    Ambros J Beer
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Str 22, 81675, Munich, Germany
    Mol Imaging Biol 13:352-61. 2011
    11)C-Choline-positron emission tomography (PET)/computed tomography (CT) is increasingly used in patients with prostate cancer. Another promising technique for assessment of tumor biology is diffusion-weighted MR imaging (DWI)...
  80. doi Quantitative measurement of betaine and free choline in plasma, cereals and cereal products by isotope dilution LC-MS/MS
    Stephen J Bruce
    Department of Bioanalytical Science, Nestle Research Centre, Lausanne, Switzerland
    J Agric Food Chem 58:2055-61. 2010
    Betaine and choline are important components of the one-carbon metabolism cycle, linked with the amino acid homocysteine and lipid metabolism...
  81. pmc Whole-brain proton MR spectroscopic imaging of mild-to-moderate traumatic brain injury and correlation with neuropsychological deficits
    Varan Govind
    Department of Radiology, University of Miami School of Medicine, Miami, Florida 33136, USA
    J Neurotrauma 27:483-96. 2010
    ..in the distribution of the magnetic resonance (MR)-observable brain metabolites N-acetyl aspartate (NAA), total choline (Cho), and total creatine (Cre), following mild-to-moderate closed-head traumatic brain injury (mTBI) were ..
  82. ncbi Evaluation of 1H-magnetic resonance spectroscopy of breast cancer pre- and postgadolinium administration
    Bonnie N Joe
    Abdominal Imaging, Department of Radiology, University of California, San Francisco 94143 0628, USA
    Invest Radiol 40:405-11. 2005
    We sought to evaluate spectroscopic measurements in breast cancer and compare variability in choline peak parameters related to contrast administration versus that inherent to repeated measurements.
  83. ncbi Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomas
    Tracy R McKnight
    Department of Radiology, University of California, San Francisco 94107, USA
    J Neurosurg 106:660-6. 2007
    ..and density both contribute to the in vivo magnetic resonance (MR) spectroscopic peak corresponding to choline-containing compounds (Cho), the authors hypothesized that multivoxel MR spectroscopy might help identify the ..
  84. doi 1H-magnetic resonance spectroscopy markers of cognitive and language ability in clinical subtypes of autism spectrum disorders
    Lidia Gabis
    Weinberg Child Development Center, Safra Children s Hospital, Tel Hashomer, Israel
    J Child Neurol 23:766-74. 2008
    ..b>Choline/creatine was also significantly elevated in the left hippocampus-amygdala and cerebellar regions of children with ..
  85. ncbi External standard method for the in vivo quantification of choline-containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla
    I J Bakken
    SINTEF Unimed, MR Center, N 7465 Trondheim, Norway
    Magn Reson Med 46:189-92. 2001
    Quantification of choline-containing compounds observed with (1)H MRS of breast tumors is of interest since such compounds have been linked to malignancy. Experiments were performed at 1...
  86. ncbi Osteoactivin expressed during cirrhosis development in rats fed a choline-deficient, L-amino acid-defined diet, accelerates motility of hepatoma cells
    Masaaki Onaga
    Department of Internal Medicine II, Miyazaki Medical College, 5200 Kihara, Kiyotake, Miyazaki 889 1692, Japan
    J Hepatol 39:779-85. 2003
    ..However, the genes involved in hepatocarcinogenesis in the context of developing cirrhosis remain unknown. This study aims to identify genes associated with early cirrhosis-associated hepatocarcinogenesis...
  87. pmc An MRI and proton spectroscopy study of the thalamus in children with autism
    Antonio Y Hardan
    Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA
    Psychiatry Res 163:97-105. 2008
    ..Lower levels of N-acetylaspartate (NAA), phosphocreatine and creatine, and choline-containing metabolites were observed on the left side in the autism group compared with controls...
  88. pmc Quantitative correlation between (1)H MRS and dynamic contrast-enhanced MRI of human breast cancer
    Hyeon Man Baek
    John Tu and Thomas Yuen Center for Functional Onco Imaging, University of California, Irvine, CA 92697 5020, USA
    Magn Reson Imaging 26:523-31. 2008
    ..resonance imaging (MRI) provide functional information, including vascular volume, vascular permeability and choline (Cho) metabolism...
  89. doi PSA doubling time for prediction of [(11)C]choline PET/CT findings in prostate cancer patients with biochemical failure after radical prostatectomy
    Giampiero Giovacchini
    Center for Molecular Bioimaging, University of Milano Bicocca, Milan, Italy
    Eur J Nucl Med Mol Imaging 37:1106-16. 2010
    Previous studies have shown that the positive detection rate of [(11)C]choline positron emission tomography/computed tomography (PET/CT) depends on prostate-specific antigen (PSA) plasma levels...
  90. doi Influence of trigger PSA and PSA kinetics on 11C-Choline PET/CT detection rate in patients with biochemical relapse after radical prostatectomy
    Paolo Castellucci
    Nuclear Medicine Unit, Hematology Oncology and Laboratory Medicine Department, Azienda Ospedaliero Universitaria di Bologna Policlinico S Orsola Malpighi, University of Bologna, Bologna, Italy
    J Nucl Med 50:1394-400. 2009
    ..purpose of this study was to investigate the effect of total prostate-specific antigen (PSA) at the time of (11)C-choline PET/CT (trigger PSA), PSA velocity (PSAvel), and PSA doubling time (PSAdt) on (11)C-choline PET/CT detection rate ..
  91. ncbi 11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer
    I J de Jong
    Department of Urology, Groningen University Hospital, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Urol 44:32-8; discussion 38-9. 2003
    ..In this study we investigated 11C-choline positron emission tomography (PET) for the evaluation after treatment of localized prostate cancer.
  92. doi Is there a role for ¹¹C-choline PET/CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase <1.5 ng/ml?
    Paolo Castellucci
    Service of Nuclear Medicine, Department of Haematology Oncology and Laboratory Medicine, Azienda Ospedaliero Universitaria di Bologna, Policlinico Sant Orsola Malpighi, University of Bologna, Bologna, Italy
    Eur J Nucl Med Mol Imaging 38:55-63. 2011
    The aim of this study was to evaluate the potential usefulness of whole-body (11)C-choline PET/CT in the re-staging of prostate cancer (PC) patients previously treated with radical prostatectomy (RP), who presented a mild increase of ..
  93. ncbi Kinetics of [(11)C]choline uptake in prostate cancer: a PET study
    Eija Sutinen
    Turku PET Centre, Turku University Central Hospital, Turku, Finland
    Eur J Nucl Med Mol Imaging 31:317-24. 2004
    Carbon-11 choline has recently been introduced as a potential tracer for tumour imaging with positron emission tomography (PET)...
  94. ncbi Prostate cancer: sextant localization with MR imaging, MR spectroscopy, and 11C-choline PET/CT
    Claudia Testa
    Department of Clinical Medicine and Applied Biotechnology D Campanacci, Diagnostic Imaging Section V Bollini, Pathologic Anatomy Unit, Institute of Oncology F Addarii, P E T Center, Policlinico S Orsola Malpighi, University of Bologna, Italy
    Radiology 244:797-806. 2007
    ..imaging, three-dimensional (3D) MR spectroscopy, combined MR imaging and 3D MR spectroscopy, and carbon 11 (11C)-choline positron emission tomography (PET)/computed tomography (CT) for intraprostatic tumor sextant localization, with ..
  95. doi The use of F-18 choline PET in the assessment of bone metastases in prostate cancer: correlation with morphological changes on CT
    Mohsen Beheshti
    PET CT Center LINZ, St Vincent s Hospital Nuclear Medicine and Endocrinology, Linz, Austria
    Mol Imaging Biol 12:98-107. 2010
    F-18 fluor choline-positron emission tomography/computed tomography (FCH-PET/CT) has emerged as a new diagnostic tool for the imaging of prostate cancer...
  96. pmc Circadian rhythms in Neurospora crassa: lipid deficiencies restore robust rhythmicity to null frequency and white-collar mutants
    P L Lakin-Thomas
    Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge CB2 3EA, United Kingdom
    Proc Natl Acad Sci U S A 97:256-61. 2000
    ..We have been investigating two mutants, cel (chain-elongation) and chol-1 (choline-requirer), which are defective in lipid synthesis and affect the period and temperature compensation of the ..
  97. ncbi Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer
    David T Price
    Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 168:273-80. 2002
    ..We evaluated the novel choline analog [18F]fluorocholine (FCH) for detecting androgen dependent and androgen independent prostate cancer, and ..
  98. doi Histological verification of 11C-choline-positron emission/computed tomography-positive lymph nodes in patients with biochemical failure after treatment for localized prostate cancer
    David Schilling
    Department of Radiology, University Hospital Tubingen, Germany
    BJU Int 102:446-51. 2008
    To evaluate the potential of (11)C-choline-positron emission tomography (PET)/computed tomography (CT) for planning surgery in patients with prostate cancer and prostate-specific antigen (PSA) relapse after treatment with curative intent.
  99. doi Proton magnetic resonance spectroscopy revealed choline reduction in the visual cortex in an experimental model of chronic glaucoma
    Kevin C Chan
    Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong
    Exp Eye Res 88:65-70. 2009
    ..Relative to the creatine level, the choline level was found to be significantly lower in the left glaucomatous visual cortex than the right control visual ..
  100. pmc Choline: an essential nutrient for public health
    Steven H Zeisel
    Department of Nutrition at the Nutrition Research Institute, School of Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nutr Rev 67:615-23. 2009
    b>Choline was officially recognized as an essential nutrient by the Institute of Medicine (IOM) in 1998. There is significant variation in the dietary requirement for choline that can be explained by common genetic polymorphisms...
  101. pmc Choline metabolism in malignant transformation
    Kristine Glunde
    The Johns Hopkins University In Vivo Cellular and Molecular Imaging Center, The Russell H Morgan Department of Radiology and Radiological Science, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Nat Rev Cancer 11:835-48. 2011
    Abnormal choline metabolism is emerging as a metabolic hallmark that is associated with oncogenesis and tumour progression...

Research Grants73

  1. Role of SAMe on UBC9 and sumolyation in liver cancer and alcoholic liver injury
    Maria Lauda Tomasi; Fiscal Year: 2012
    ..Chronic hepatic SAMe deficiency occurs in MAT1A knockout (KO) mice, which exhibit increased propensity to choline-deficient diet induced fatty liver, higher level of lipid peroxidation, spontaneous development of ..
  2. Prospective studies of cancer etiology and prevention in Shanghai and Singapore
    Jian Min Yuan; Fiscal Year: 2013
    ..nonsmokers;(3) to assess the role of methyl groups - S-adenosylmethionine, S-adenosylhomocysteine, methionine, choline, homocysteine, folate, vitamins B6 and B12 in the development of liver cancer;(4) to assess the role of genetic ..
  3. The Habenulo-Interpeduncular Pathway and Nicotine
    Christie D Fowler; Fiscal Year: 2013
    ..will be injected into select brain regions to permit transfection of cholinergic neurons/axons in BAC transgenic choline acetyltransferase (ChAT)::Cre mice...
  4. Interrelationships among nutrients involved in one-carbon metabolism in Banglades
    MEGAN NINA HALL; Fiscal Year: 2011
    ..Specifically, the roles of two nutrients, choline and betaine, i.e...
  5. Transplantation of Reduced-Size Fatty Livers
    Zhi Zhong; Fiscal Year: 2010
    ..Fatty livers will be induced by high fat diet and choline-deficient diet, respectively, and reduced to 30% to 50% of original size...
  6. Role of microRNA-122 in hepatocarcinogenesis using conditional knock out mice
    Kalpana Ghoshal; Fiscal Year: 2013
    ..to AlbCre mice and spontaneously develop hepatitis in the liver with age, which is facilitated after feeding choline-deficient diet that promotes hepatocarcinogenesis...
  7. Epigenetics and choline: mediation of fetal alcohol effects in a rat model
    Carol L Cheatham; Fiscal Year: 2013
    ..Scientists working with animal models have provided evidence that choline supplementation given concomitant with or after fetal alcohol exposure mediates the effects...
  8. NEWBORN IRON DEFICIENCY
    Michael K Georgieff; Fiscal Year: 2013
    ..capitalize on our understanding of the basic mechanisms of the short and long-term neuropathology to test whether choline treatment in addition to iron normalizes neuronal development and adult memory function...
  9. Atherogenic mechanism of lipid peroxidation-derived aldehydes
    Sanjay Srivastava; Fiscal Year: 2013
    ..Aldehydes such as 4-hydroxynonenal (HNE) and 1-palmitoyl-2-(5-oxovaleroyl)-3- glycero- phosphatidyl choline (POVPC) are the major bioactive products generated from the oxidation of LDL...
  10. Lipid peroxidation product induced DNA damage in the p53 gene and liver cancer
    ERIC MOON SHONG M TANG; Fiscal Year: 2010
    ..In rats HCC can be induced by a choline-deficient diet (CDD)...
  11. Epigenetic programming of brain development by choline nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2011
    ..to the supply of essential nutrients and in particular to the supply of metabolic methyl group donors including choline. The central hypothesis to be tested by the studies described in this proposal is that alterations in the ..
  12. Risk factors for orofacial clefts
    Suzan L Carmichael; Fiscal Year: 2011
    ..pro-vitamin A, vitamins C and E, zinc) or promote it (iron, saturated fat);2) methyl group metabolism - betaine, choline, folate, methionine, riboflavin, vitamin B6, vitamin B12, zinc;and 3) glycemic control - dietary glycemic load;..
  13. Functional analysis of Phospholipase D4
    David Nemazee; Fiscal Year: 2010
    ..Related family member proteins, such as PLD1 and PLD2 convert phosphatidyl choline (PC) to phosphatidic acid, releasing choline, a reaction that has effects on both cell signaling and membrane ..
  14. Structure and Function of Enzymes in Fatty Acid Oxidation
    JUNG JA P KIM; Fiscal Year: 2013
    ..DD functions in choline metabolism and is not a member of the AD family, but donates electrons to ETF...
  15. Biomarkers of Aggressive Oral Cancer
    THEKKELNAYCKE RAJENDIRAN; Fiscal Year: 2013
    ..and glutaminolysis, increased amino acid influx into the Krebs cycle, and altered energy metabolism, membrane choline phospholipid metabolism, and oxidative/osmotic defense mechanisms...
  16. Aging of brain: effects of perinatal nutrition
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    The overall goal of our studies is to determine the mechanisms by which prenatal availability of choline, and of methyl groups derived from folic acid, modify brain structure and function during development, adulthood and old age...
  17. Dietary Methyl Score, Genomic DNA Methylation and Colorectal Cancer
    Eunyoung Cho; Fiscal Year: 2012
    ..Several dietary factors including folate, alcohol, methionine, riboflavin, vitamins B6 and B12, choline, and betaine mediate or facilitate one-carbon metabolism pathway...
  18. Molecular-Genetic Dissection of Basal Forebrain Circuitry Regulating Arousal
    PATRICK MICHAEL FULLER; Fiscal Year: 2013
    ..AAV) vector containing cre-recombinase injected into the BF of mice harboring loxP-modified alleles of either choline acetyltransferase (ChATflox/flox mice), the vesicular GABA transporter (Vgat flox/flox mice) or the vesicular ..
  19. Systemic Chemotherapy of Melanoma: NMR Studies of Lonidamine &N-Mustard Activity
    Jerry D Glickson; Fiscal Year: 2013
    ..3) To evaluate potential 1H NMR markers for noninvasive early detection of response--lactate and total choline by MRS and apparent diffusion constant (ADC) and T2 measured by MRI.
  20. Antenatal Dietary Supplementation is a Risk Factor for Infant Atopy Through Epige
    DAVID ALBERT SCHWARTZ; Fiscal Year: 2010
    ..low risk of atopy, and that antenatal dietary supplementation with methyl donors such as folate, vitamin B12, and choline enhance these epigenetic differences in infants with atopy...
  21. Host-associated regulation of P. aeruginosa colonization and virulence
    Deborah A Hogan; Fiscal Year: 2013
    ..One important P. aeruginosa virulence factor is a secreted phospholipase C, PlcH, which degrades choline- containing phospholipids, such as phosphatidylcholine (PC), that are highly abundant in the lung...
  22. Targeting Pneumococcal Virulence Factors in Otitis Media
    Honggao Yan; Fiscal Year: 2012
    ..two-year grant application, we propose to develop aptamers against two major pneumococcal virulence factors, choline-binding protein A (CbpA, also known as PspC or SpsA) and pneumococcal surface protein A (PspA)...
  23. Roles of Phospholipase D in AT1 Receptor Endocytosis
    Guangwei Du; Fiscal Year: 2010
    ..PLD2, both of which catalyze the hydrolysis of phosphatidylcholine (PC) to generate phosphatidic acid (PA) and choline. PLD2-generated PA has been proposed to regulate a number of endocytic and actin regulatory proteins and several ..
  24. Impact of Estrogens and Menopause on Interacting Monoamine Neurotransmitters in t
    Jeffrey K Yao; Fiscal Year: 2013
    ..will be dissected and analyzed for levels of monoamines, monoamine metabolites, amino acid neurotransmitters, and choline acetyltransferase (a marker of cholinergic neurons)...
  25. The Role of PcpA in the Mechanism of Virulence and Protective Immunity.
    MELISSA MARIE WALKER; Fiscal Year: 2013
    ..This project investigates the virulence and protection-eliciting properties of pneumococcal choline-binding protein A (PcpA). PcpA contains leucine-rich repeats (LRR)...
  26. Nutrients involved 1-carbon metabolism and the methylation of arsenic and DNA
    MEGAN NINA HALL; Fiscal Year: 2013
    ..Specifically, the roles of two nutrients, choline and betaine - i.e...
  27. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    ..Folate, vitamin A, and choline intake will be of primary interest...
  28. UNC-CH Nutrition Obesity Research Center
    Steven H Zeisel; Fiscal Year: 2013
    ..have made fundamental contributions to the understanding of the genes that regulate activity, lipid and choline metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and ..
  29. Near-Infrared Fluorescent Choline Kinase Inhibitors for Cancer Imaging and Therap
    SEAN ARLAUCKAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The aim of this research is to image the expression of choline kinase (ChoK) in breast tumors using near-infrared (NIR) fluorescent choline analogs capable of disrupting lipid metabolism in cancer ..
  30. Maternal methyl diet and epigenetic imprint in offspring mammary carcinogenesis
    CHUNG SUN PARK; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Lipotropes (methionine, choline, folate, and vitamin B12) are dietary methyl donors and cofactors that are involved in one-carbon (methyl) metabolism (i.e...
  31. Risk Factors for Craniosynostosis
    Suzan L Carmichael; Fiscal Year: 2010
    ..glycemic control or oxidative stress are associated with risk of CS among offspring, including folate/folic acid, choline, betaine, methionine, vitamin B12, vitamin B6, riboflavin, glycemic load, [unreadable]-carotene, vitamin E, and ..
  32. Designing an Integrated Nanoscale System for Ion Channel Structure-Function Study
    Ratneshwar Lal; Fiscal Year: 2013
    ..a potential supporter of this application, we will study two important ion channels: hemichannels and Acetyl choline receptor (AChR) that are intimately related to drug addiction...
  33. Functional Genomics and Molecular Imaging of Liver Disease and Cancer
    GORDON SHOJI OKIMOTO; Fiscal Year: 2013
    ..How- ever, it is not certain at this time whether the changes in choline phospholipid metabolism are due to an in- creased demand for membrane phospholipids or an increase in mitogenic ..
  34. Gut flora metabolism of dietary phosphatidylcholine and cardiovascular disease
    Stanley L Hazen; Fiscal Year: 2013
    ..The overall pathway involves an interplay between dietary intake of lipid (the choline moiety of phosphatidyl choline), intestinal microbiota (gut flora), genetic susceptibility (hepatic expression ..
  35. The Role of the Nicotinic Cholinergic Pathway in Retinopathy of Prematurity
    John P Cooke; Fiscal Year: 2013
    ..the level of expression and localization of key elements of the nAChR pathway including the high affinity choline transporter, choline acetyltransferase, and the nAChR subunits...
  36. Optimization of Protein Therapeutics Formulations
    Lawrence J Delucas; Fiscal Year: 2012
    ..domain-1 of CFTR and phospholipase-D1 (a human enzyme responsible for the hydrolysis of phosphatidyl choline)...
  37. Homeostatic Regulation of Folate Metabolism
    Patrick J Stover; Fiscal Year: 2010
    ..4. TS and cSHMT expression are coordinately regulated. 5. regulation of cSHMT by folate/choline preserves dTMP pools at the expense of AdoMet synthesis. The long-term goals of this project are: 1...
  38. Congenital Myasthenic Syndromes: Pathogenic Mechanisms
    RICARDO ANIBAL MASELLI; Fiscal Year: 2013
    ..During the last decade the genes encoding six other molecular targets, including the enzyme choline acetyltransferase (CHAT), rapsyn (RAPSN), the voltage-gated muscle sodium channel (SCN4A), the muscle-specific ..
  39. Parenteral Methionine Requirements in Septic Children
    Leticia Castillo; Fiscal Year: 2013
    ..and cysteine are important in critical illness due to methionine role as a methyl group donor for creatine, choline and DNA methylation, and as the precursor of cysteine, the rate limiting amino acid in glutathione (GSH) ..
  40. Fate-mapping temporally marked precursor populations to hepatocellular carcinoma
    Hyam L Leffert; Fiscal Year: 2013
    ..three specific Aims: in Aim 1, {ROSA26 ZsGreen1 ('ZSG1') mice will be fed an hepatocarcinogenic diet (choline-deficiency + ethionine)} to monitor the induction of AFP+ oval cells and their putative descendants (HCCs;HCC-..
  41. The effect of a protein-lipid complex from human milk against pneumococcal otitis
    Emily Clementi; Fiscal Year: 2013
    ..First, the receptor structure for HAMLET will be elucidated by testing various preparations of choline-containing pneumococcal surface components for their ability to inhibit HAMLET-induced death and to interact with ..
  42. 1H NMR STUDIES OF NON-HODGKINS LYMPHOMA
    Jerry D Glickson; Fiscal Year: 2012
    ..We have evaluated the utility of 1H MRS measurements of total choline and lactate and 1H MRI (diffusion-weighted and T2-weighted with dynamic contrast-enhanced and T1A-weighted) in ..
  43. Perinatal choline therapy in a mouse model of Down Syndrome &Alzheimer's Disease
    Barbara J Strupp; Fiscal Year: 2012
    ..We recently completed a study to test the hypothesis that supplementation of the maternal diet with excess choline during pregnancy and lactation would lessen the attentional dysfunction seen in Ts65Dn mice...
  44. Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
    Andrea Baccarelli; Fiscal Year: 2013
    ..e., folic acid, Vitamins B6 &B12, betaine, methionine, and choline) can avert this DNA methylation loss and mitigate the cardiovascular effects induced by PM exposure...
  45. Drug Discovery for Cognitive Impairment Associated with Drugs of Abuse
    Alvin V Terry; Fiscal Year: 2013
    ..We have been studying a small library of analogs of choline that were originally characterized based on their cytoprotective actions...
  46. The Role of Maternal Nutrition in the Teratogenesis of Alcohol in Humans
    Robert Colin Carter; Fiscal Year: 2013
    ..domains: 1) energy intake and gestational weight gain;2) iron status;3) methyl donor status (folate, vitamin B12, choline)...
  47. Citicoline Treatment of Methamphetamine Dependence
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    ..We therefore propose citicoline (CDP-choline as a nutritional supplement) for the potential adjunctive treatment of MA dependence as a response to RFA-DA-09-..
  48. Quantitative Biomarker Imaging for Early Therapy Response Assessment in Cancer
    James M Mountz; Fiscal Year: 2013
    ..Similarly, MRSI can be used to assess choline metabolism, which reflects membrane turnover, through the measurement of total choline and phosphocholine...
  49. Time Resolved Breast Imaging Using a Combined MRI and Optical Tomography Approach
    STEFAN ALEXANDRU CARP; Fiscal Year: 2013
    ..as early predictors of response, with studies showing that 18F-FDG PET as well as diffusion weighted (DW) MRI and choline-compounds MR spectroscopy (tCho-MRS) measurements correspond well with therapy success within a few weeks from ..
  50. New Insights into Motor Neuron Disease
    John K Fink; Fiscal Year: 2013
    ..fluorophosphates (DFP);Induced Pluripotent Stem (IPS) cell;50% inhibitory concentration (IC50) lysphophosphatidyl choline (LPC);mipafox (MIP);Motor Neuron Disease (MND);Neuropathy Target Esterase (NTE), Organophosphorous: OP;cyclic AMP ..
  51. A Tissue Implantable Microbiosensor
    Peter A Petillo; Fiscal Year: 2012
    ..non-electroactive, neurologically relevant analytes, including, but not limited to, glucose, glutamate, lactate, choline, histamine, D-serine, and ethanol...
  52. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2009
    ..Excretion;Kinetics;LSC;In vivo;In vitro;Radiolabeled compounds;Dermal;Gavage;IV;Inhalation;Mass balance;Fullerene;Choline, Dimethylethanolamine;2[unreadable],2[unreadable][unreadable][unreadable]-Dithiobisbenzanilide, 2-Hydroxy-4-..
  53. ABSORPTION, DISTRIBUTION, METABOLISM, AND EXCRETION (ADME) IN MAMMALS
    Jacob McDonald; Fiscal Year: 2011
    ..Excretion;Kinetics;LSC;In vivo;In vitro;Radiolabeled compounds;Dermal;Gavage;IV;Inhalation;Mass balance;Fullerene;Choline, Dimethylethanolamine;2',2'''-Dithiobisbenzanilide, 2-Hydroxy-4-methoxybenzophenone, Chromium,..
  54. Choline kinase: a novel target for rheumatoid arthritis
    Monica Guma; Fiscal Year: 2013
    ..The research proposal will focus on the role of choline kinase in chronic inflammation and joint destruction associated with RA...
  55. Interventions to Test the alpha 7 Nicotinic Receptor Model in Schizophrenia
    Stephen Deutsch; Fiscal Year: 2009
    ..The aim of this R34 proposal is to conduct a "proof of concept" clinical trial combining galantamine and CDP-choline. We hypothesize that galantamine will prevent desensitization, allowing choline to serve as a selective agonist, ..
  56. Host sphingolipids and fungal infection
    Maurizio Del Poeta; Fiscal Year: 2011
    ..SMS transfers a choline phosphate moiety from phosphatidylcholine (PC) to ceramide, therefore producing sphingomyelin (SM) and ..
  57. Alcohol induced enrichment of regulatory T cells
    Makio Iwashima; Fiscal Year: 2010
    ..PLD is an enzyme that catalyzes hydrolysis of phosphatidyl choline, a major phospholipid found in lipid bilayers, into phosphatidic acid (PA) and choline...
  58. Metabolite Profiling and Cardiovascular Mortality in End-stage Renal Disease
    Eugene P Rhee; Fiscal Year: 2013
    ..metabolic pathways in ESRD, and specifically advances 3 candidate metabolites - adipic acid, kynurenic acid, and choline - with potential relevance to cardiovascular outcomes...
  59. SKELETAL MUSCLE DE NOVO LIPOGENESIS AND THE GLUCOSE-FATTY ACID CYCLE
    Katsuhiko Funai; Fiscal Year: 2013
    ..The PI has now generated mice with skeletal muscle-specific deletion of choline/ethanolamine phosphotransferase-1 (CEPT1), a terminal enzyme in de novo PE biosynthesis...
  60. Neonatal Methamphetamine Effects on Adult Cholinergic and Cognitive Function
    Jessica A Siegel; Fiscal Year: 2010
    ..The specific aims of this proposal are: 1) determine the effects of neonatal MA on choline acetyltransferase positive cells in the basal forebrain and fiber densities innervating the hippocampus and ..
  61. The Neuroimmunology of Anhedonia
    Vilma Gabbay; Fiscal Year: 2013
    ..We documented associations between blood KP neurotoxins and striatal choline (membrane turnover marker) levels along with decreased anterior cingulate cortex (ACC) 3- aminobutyric acid (GABA)..
  62. Exploratory Trial of Choline Supplementation for Fetal Alcohol Syndrome
    Sandra W Jacobson; Fiscal Year: 2013
    ..are frequently ineffective, NIAAA has highlighted "the potential of maternal dietary supplementation with choline, folate, and other nutrients to interact with alcohol to reduce the risk of FASD" as a priority research area...
  63. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..Recent data in rats show that ethanol-induced behavioral deficits can be ameliorated by transplantation of fetal, choline-rich tissue...
  64. DIVALENT CATIONS AND CARDIAC LIPID METABOLISM
    MARGARET WEIS; Fiscal Year: 1990
    ..free buffer, while the incorporation of labelled arachidonate into tissue phospholipids, especially phosphatidyl choline and phosphatidyl ethanolamine, is significantly reduced...
  65. A Nonisotopic HTS Assay to Elucidate Choline Transporter (CHT) Modulators
    ALICIA RUGGIERO; Fiscal Year: 2009
    ..Another vital protein, the hemicholinium-3 sensitive choline transporter (CHT) is believed to be responsible for the efficient uptake of choline by neurons to allow for ACh ..
  66. MODULATION OF CHOROID PLEXUS CHOLINE TRANSPORT BY METALS
    Alice Villalobos; Fiscal Year: 2002
    ..goal of this research is to establish an experimental system for predicting physicochemical stress-modulation of choline transport across the cerebrospinal fluid (CSF)-blood barrier, i.e., the choroid plexus epithelium...
  67. Prostate MRI and MRS: Correlations with Gene Expression
    Sandra Gaston; Fiscal Year: 2007
    ..The metabolic changes characteristic of MRS spectra of malignant areas of the prostate gland include increased choline and decreased citrate peaks...
  68. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    Significance and goal: CDP-choline (citicoline) stroke clinical trials in Europe and Japan showed significant improvement, while US studies provided ambiguous results...
  69. ABNORMAL METABOLISM IN ALCOHOLIC CIRRHOSIS
    Rajender Chawla; Fiscal Year: 1993
    ..e., levels 2SD below normal average) of cysteine and choline, nutrients considered nonessential and deficient in the elemental formulae...
  70. CLINICAL METABOLIC CORRELATION IN DEMENTIA BY PROTON NMR
    William Klunk; Fiscal Year: 1999
    ..measurable by 1/H MRS include N-acetyl- L-aspartate (NAA), L-glutamate, GABA, glutamine, myo-inositol, choline- containing compounds, creative and others...
  71. DNA CONTENT OF DYSPLASTIC LESIONS IN HUMAN AND RAT LIVER
    Oscar Sudilovsky; Fiscal Year: 1991
    ..years we have not only confirmed the initial finding, but also determined that aneuploidy is present when either choline deficiency or phenobarbital are given separately after the same initiation treatment with diethylnitrosamine...
  72. Advanced NMR/MRI Methods for Liver Cancer
    YASVIR TESIRAM; Fiscal Year: 2009
    ..quantum coherence spectroscopy, our preliminary year long study of hepatocarcinogenesis in the rat, induced by a choline deficient (CD) diet, showed marked differences in fatty acid species when compared to controls...
  73. CHOLINE AND LUNG SURFACTANT METABOLISM
    Aron Fisher; Fiscal Year: 1992
    ..is to evaluate control of lung surfactant phosphatidylcholine synthesis with special emphasis on the role of choline as a rate-limiting substrate...