dimethylnitrosamine

Summary

Summary: A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.

Top Publications

  1. ncbi Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
    S Tada
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-12 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Clin Exp Pharmacol Physiol 28:522-7. 2001
  2. ncbi A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation
    Jiun Yu Chen
    Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
    J Ethnopharmacol 142:811-8. 2012
  3. ncbi Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
    E Olatunde Farombi
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Food Chem Toxicol 46:1279-87. 2008
  4. ncbi The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    Wei Qing Li
    Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    FEBS J 278:1522-32. 2011
  5. ncbi Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model
    Kyung Hee Jung
    Clinical Research Center, College of Medicine, Inha University, Incheon 400 712, Korea
    J Pineal Res 47:173-83. 2009
  6. pmc Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis
    Yoshiyuki Takahara
    Exploratory and Applied Pharmaceutical Research Department, Pharmaceutical Company, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    World J Gastroenterol 12:6473-99. 2006
  7. pmc Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis
    Anne Charlotte de Gouville
    Biology Department, GlaxoSmithKline, 25 Avenue du Quebec, Les Ulis 91951, France
    Br J Pharmacol 145:166-77. 2005
  8. ncbi Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats
    Cheng Liu
    Institute of Liver Diseases, Shuguang Hospital, Shanghai, People s Republic of China
    Lab Invest 90:1805-16. 2010
  9. ncbi Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats
    Masahiko Kusunose
    Department of Pharmacy, Kochi Medical School Hospital, Kochi, Japan
    Biol Pharm Bull 25:1417-21. 2002
  10. ncbi Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
    M Pines
    Institute of Animal Science, Volcani Center, Bet Dagan, Israel
    J Hepatol 27:391-8. 1997

Research Grants

Detail Information

Publications196 found, 100 shown here

  1. ncbi Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
    S Tada
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-12 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Clin Exp Pharmacol Physiol 28:522-7. 2001
    ..preventive effects of pirfenidone (PFD), an antifibrotic agent, on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. 2. Treatment with DMN caused a significant decrease in bodyweight and liver weight...
  2. ncbi A Chinese herbal medicine, Gexia-Zhuyu Tang (GZT), prevents dimethylnitrosamine-induced liver fibrosis through inhibition of hepatic stellate cells proliferation
    Jiun Yu Chen
    Department of Life Sciences, and Agricultural Biotechnology Center, National Chung Hsing University, Taichung 402, Taiwan
    J Ethnopharmacol 142:811-8. 2012
    ..Gexia-Zhuyu Tang (GZT), also called Gexiazhuyu decoction (GXZYD), is a traditional Chinese herbal medicine for chronic liver diseases such as cirrhosis and liver fibrosis...
  3. ncbi Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1
    E Olatunde Farombi
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151 742, Republic of Korea
    Food Chem Toxicol 46:1279-87. 2008
    ..that oral administration of curcumin at 200mg/kg dose for four consecutive days not only protected against dimethylnitrosamine (DMN)-induced hepatic injury, but also resulted in more than three-fold induction of HO-1 protein ..
  4. ncbi The rno-miR-34 family is upregulated and targets ACSL1 in dimethylnitrosamine-induced hepatic fibrosis in rats
    Wei Qing Li
    Department of Pathology, Changzheng Hospital, Second Military Medical University, Shanghai, China
    FEBS J 278:1522-32. 2011
    ..Here, we sought to examine whether microRNA (miRNA) became dysregulated in dimethylnitrosamine-induced hepatic fibrosis in rats...
  5. ncbi Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model
    Kyung Hee Jung
    Clinical Research Center, College of Medicine, Inha University, Incheon 400 712, Korea
    J Pineal Res 47:173-83. 2009
    ..The study aimed to determine whether melatonin could prevent dimethylnitrosamine (DMN)-induced liver injury through nuclear erythroid 2-related factor 2 (Nrf2) and inflammation...
  6. pmc Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis
    Yoshiyuki Takahara
    Exploratory and Applied Pharmaceutical Research Department, Pharmaceutical Company, Ajinomoto Co, Inc, 1 1 Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    World J Gastroenterol 12:6473-99. 2006
    ..To determine the gene expression profile data for the whole liver during development of dimethylni-trosamine (DMN)-induced hepatic fibrosis...
  7. pmc Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis
    Anne Charlotte de Gouville
    Biology Department, GlaxoSmithKline, 25 Avenue du Quebec, Les Ulis 91951, France
    Br J Pharmacol 145:166-77. 2005
    ..in TGF-beta-overexpressing transgenic mice, in an acute model of liver disease and in a chronic model of dimethylnitrosamine (DMN)-induced liver fibrosis...
  8. ncbi Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats
    Cheng Liu
    Institute of Liver Diseases, Shuguang Hospital, Shanghai, People s Republic of China
    Lab Invest 90:1805-16. 2010
    ..Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment...
  9. ncbi Effect of Sho-saiko-to extract on hepatic inflammation and fibrosis in dimethylnitrosamine induced liver injury rats
    Masahiko Kusunose
    Department of Pharmacy, Kochi Medical School Hospital, Kochi, Japan
    Biol Pharm Bull 25:1417-21. 2002
    ..The liver injury model rats were produced by administration of various doses of dimethylnitrosamine (DMN) and Sho-saiko-to extract was administered to these rats...
  10. ncbi Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
    M Pines
    Institute of Animal Science, Volcani Center, Bet Dagan, Israel
    J Hepatol 27:391-8. 1997
    ..We evaluated the effect of halofuginone-a specific inhibitor of collagen type alpha 1(I) gene expression-on dimethylnitrosamine (DMN)-induced liver fibrosis/cirrhosis in rats.
  11. ncbi Neoplastic and nonneoplastic liver lesions induced by dimethylnitrosamine in Japanese medaka fish
    K R Hobbie
    Integrated Laboratory Systems, Research Triangle Park, NC, USA
    Vet Pathol 49:372-85. 2012
    ..b>Dimethylnitrosamine, used in rats to model human alcoholic cirrhosis and hepatic neoplasia, is also a potent hepatotoxin and ..
  12. ncbi Comparison of the in vitro mutagenicity and metabolism of dimethylnitrosamine and benzo[a]pyrene in tissues from inbred mice treated with phenobarbital, 3-methylcholanthrene or polychlorinated biphenyls
    J J Hutton
    Mutat Res 66:75-94. 1979
    ..and colon from 8 strains of mice were compared for their ability to metabolize benzo[a]pyrene (BP) and dimethylnitrosamine (DMN) to mutagens...
  13. ncbi The hepatoprotective effect of Bupleurum kaoi, an endemic plant to Taiwan, against dimethylnitrosamine-induced hepatic fibrosis in rats
    Ming Hong Yen
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC
    Biol Pharm Bull 28:442-8. 2005
    ..kaoi, an endemic plant to Taiwan, were used to be examined the hepatoprotective effect against dimethylnitrosamine (DMN)-induced hepatic fibrosis in rats, they were water extract (BKW), polysaccharide-enriched fractions (..
  14. ncbi [Role of hepatic sinusoidal endothelium injury in hepatic fibrogenesis induced by dimethylnitrosamine in rats]
    Xiong Lu
    Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Zhonghua Gan Zang Bing Za Zhi 10:441-4. 2002
    To study the role of hepatic sinusoidal endothelium injury during hepatic fibrogenesis induced by dimethylnitrosamine (DMN) in rats.
  15. ncbi Protective effects of Flos lonicera extract on acute liver injury by dimethylnitrosamine-induced in rats
    Yang Teng
    Department of Chemistry and Pharmacy, Jiamusi University, Jiamusi 154007, Heilongjiang, China
    J Nat Med 64:288-94. 2010
    ..effects of Flos lonicera extract (FLE) on acute liver injury model rats which induced by 35 mg/kg dimethylnitrosamine (DMN)...
  16. ncbi DNA methylation in rat liver by daminozide, 1,1-dimethylhydrazine, and dimethylnitrosamine
    P Sagelsdorff
    Institute of Toxicology, Swiss Federal Institute of Technology, Schwerzenbach
    Fundam Appl Toxicol 11:723-30. 1988
    ..succinic acid 2',2'-dimethylhydrazide; 37 mg/kg), 1,1-[14C]dimethylhydrazine (UDMH; 19 mg/kg), and [14C]dimethylnitrosamine (DMNA; 0.1 mg/kg) were administered by oral gavage to male Sprague-Dawley rats...
  17. ncbi Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats
    Ming Fen Lee
    Department of Nutrition and Health Sciences, Chang Jung Christian University, Tainan 71101, Taiwan, ROC
    Food Chem 138:802-7. 2013
    ..These data demonstrated that pterostilbene exhibited hepatoprotective effects on experimental fibrosis, potentially by inhibiting the TGF-β1/Smad signaling...
  18. ncbi Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice
    Giovanni Latella
    Department of Internal Medicine, GI Unit, University of L Aquila, L Aquila, Italy
    Liver Int 29:997-1009. 2009
    ..Transforming growth factor-beta (TGF-beta)/Smad3 signalling plays a central role in tissue fibrogenesis, acting as a potent stimulus of ECM accumulation...
  19. ncbi N-acetylcysteine attenuates dimethylnitrosamine induced oxidative stress in rats
    Priya Sathish
    Department of Pharmacology and Environmental Toxicology, Dr A L M Postgraduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600 113, India
    Eur J Pharmacol 654:181-6. 2011
    ..was aimed to investigate the hepatoprotective and antioxidant property of N-acetylcysteine (NAC) against dimethylnitrosamine (DMN) induced oxidative stress and hepatocellular damage in male Wistar albino rats...
  20. ncbi The flavonoid naringenin inhibits dimethylnitrosamine-induced liver damage in rats
    Mi Hye Lee
    College of Pharmacy, Pusan National University, Changjeon dong, Kumjeong gu, Pusan 609 735, Korea
    Biol Pharm Bull 27:72-6. 2004
    ..In this study, we investigated the protective effect of naringenin on hepatic injury induced by dimethylnitrosamine (DMN) in rats...
  21. pmc Oncostatin M gene therapy attenuates liver damage induced by dimethylnitrosamine in rats
    Tetsuhiro Hamada
    Department of Pathology, Hyogo College of Medicine, 1, Mukogawa, Nishinomiya, Hyogo 663 8501, Japan
    Am J Pathol 171:872-81. 2007
    ..we examined whether the introduction of OSM cDNA enhances the regeneration of livers damaged by dimethylnitrosamine (DMN) in rats...
  22. ncbi Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats
    Chang Shin Lim
    College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea
    Biosci Biotechnol Biochem 74:477-83. 2010
    ..In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN)...
  23. ncbi Hepatoprotective effects of Yi Guan Jian, an herbal medicine, in rats with dimethylnitrosamine-induced liver fibrosis
    Hung Jen Lin
    School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
    J Ethnopharmacol 134:953-60. 2011
    ..The present investigation was designed to assess the involvement of the fibrosis pathway in dimethylnitrosamine (DMN)-induced liver fibrosis in rats.
  24. ncbi Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats
    Veysel Tahan
    Dpeartment of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
    J Pineal Res 37:78-84. 2004
    ..We aimed to test the effects of melatonin on dimethylnitrosamine (DMN)-induced liver damage in rats. Wistar albino rats were injected with DMN intraperitoneally...
  25. ncbi Increased oxidative stress in dimethylnitrosamine-induced liver fibrosis in the rat: effect of N-acetylcysteine and interferon-alpha
    G Vendemiale
    Department of Internal and Public Medicine DIMIMP, University of Bari, Bari, Italy
    Toxicol Appl Pharmacol 175:130-9. 2001
    ..This study evaluated (1) the effect of the profibrotic agent dimethylnitrosamine (DMN) on the hepatic oxidative balance in the rat; (2) the role played by the antioxidant agent N-..
  26. ncbi A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea
    S Asakura
    Tsukuba Drug Safety Research, Drug Safety Research Laboratories, Eisai Co, Ltd, Ibaraki, Japan
    Toxicol Lett 98:155-67. 1998
    ..effects were studied in the hepatocytes of F344 rats exposed in vivo to the methylating agents dimethylnitrosamine (DMN, hepatocarcinogen) and methylnitrosourea (MNU, non-hepatocarcinogen)...
  27. ncbi Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression
    Yong Pil Hwang
    Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Food Chem Toxicol 49:93-9. 2011
    ..We examined whether an anthocyanin fraction (AF) from purple sweet potato may prevent dimethylnitrosamine (DMN)-induced liver injury by inducing antioxidants via nuclear erythroid 2-related factor 2 (Nrf2) ..
  28. ncbi Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro
    Andrea Galli
    Gastroenterology Unit, Department of Clinical Pathophysiology, University of Florence, Florence, Italy
    Gastroenterology 122:1924-40. 2002
    ..The aim of our study was to evaluate whether oral administration of synthetic PPARgamma ligands, thiazolidinediones (TZD), might affect collagen deposition in animal models of liver fibrosis...
  29. ncbi The Effect of N-nitrosodimethylamine on TRAIL and DR5 expression in human neutrophils--preliminary study
    Jakub Jabłoński
    Department of Toxicology, Medical University of Białystok, Białystok, Poland
    Immunopharmacol Immunotoxicol 29:287-96. 2007
    ..However, the expression and secretion of DR5 by PBMCs were similar to those by PMNs. Differences above suggest that PMNs are more sensitive to unfavorable action of NDMA than PBMCs...
  30. ncbi Pathogenic roles of tumor necrosis factor receptor p55-mediated signals in dimethylnitrosamine-induced murine liver fibrosis
    Kazuya Kitamura
    Department of Gastroenterology, Graduate School of Medicinal Sciences, Division of Molecular Bioregulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Lab Invest 82:571-83. 2002
    ..the pathophysiologic role of the TNF-alpha/TNF receptor (TNFR) p55 signals in liver fibrosis, 10 mg/kg of dimethylnitrosamine, a specific hepatotoxicant, was administered twice a week into the peritoneal cavity of both TNFRp55 knock-..
  31. ncbi Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats
    Lee Won Chong
    Graduate Institute of Clinical Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 13:403-18. 2006
    ..An in vivo therapeutic study was conducted in dimethylnitrosamine (DMN)-treated rats, which were randomly assigned to 1 of 4 groups: vehicle (0...
  32. pmc Comparison of liver regeneration after a splenectomy and splenic artery ligation in a dimethylnitrosamine-induced cirrhotic rat model
    Akio Morinaga
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume City, Fukuoka, Japan
    HPB (Oxford) 12:22-30. 2010
    ..However, there are no studies that directly compared the effects of a splenectomy and splenic artery ligation. In the present study, we compared the effects of a splenectomy and splenic artery ligation in cirrhotic rats...
  33. ncbi Biochemical abnormalities during the progression of hepatic fibrosis induced by dimethylnitrosamine
    J George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Biochem 33:563-70. 2000
    ..To obtain more information about the alteration of biochemical and metabolic parameters during alcoholic liver fibrosis, we have monitored the changes of certain important biochemical compounds in experimentally induced hepatic fibrosis...
  34. ncbi A selective ROCK inhibitor, Y27632, prevents dimethylnitrosamine-induced hepatic fibrosis in rats
    S Tada
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hepatol 34:529-36. 2001
    ..that an inhibitor specific for p160ROCK (Y27632) could prevent experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats...
  35. ncbi Effect of Clonorchis sinensis infection and dimethylnitrosamine administration on the induction of cholangiocarcinoma in Syrian golden hamsters
    J H Lee
    Department of Parasitology, College of Medicine, Korea University, Seoul
    Korean J Parasitol 31:21-30. 1993
    ..Clonorchis sinensis infection on induction of cholangiocarcinoma in Syrian golden hamsters to which 15 ppm dimethylnitrosamine (DMN) solution was administered for 8 weeks...
  36. ncbi Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine
    Soo K Bae
    Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, San 56 1, Shinlim Dong, Kwanak gu, Seoul 151 742, South Korea
    Int J Pharm 275:227-38. 2004
    ..at a dose of 30 mg/kg to control Sprague-Dawley rats and rats with liver cirrhosis induced by dimethylnitrosamine. After intravenous administration in rats with liver cirrhosis, the area under the plasma concentration-..
  37. ncbi Baculovirus-mediated interferon alleviates dimethylnitrosamine-induced liver cirrhosis symptoms in a murine model
    Y Nishibe
    Department of Life and Environmental Science, Chiba Institute of Technology, Chiba, Japan
    Gene Ther 15:990-7. 2008
    ..investigated the in vivo effect of AcMNPV in the mouse model of liver cirrhosis induced by the mutagen dimethylnitrosamine. Intraperitoneal injection of AcMNPV induced an immune response...
  38. ncbi The flavonoid quercetin inhibits dimethylnitrosamine-induced liver damage in rats
    Eun Sil Lee
    College of Pharmacy, Pusan National University, Kumjeonggu, Pusan 609 735, Korea
    J Pharm Pharmacol 55:1169-74. 2003
    ..In this study, we investigated the protective effect of quercetin on hepatic injury induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight...
  39. ncbi Dimethyl sulfoxide inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
    M Nakamuta
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int J Mol Med 8:553-60. 2001
    We studied the preventive effects of dimethyl sulfoxide (DMSO) on experimental hepatic fibrosis induced by dimethylnitrosamine (DMN) in rats. Treatment with DMN caused a significant decrease in body and liver weight...
  40. ncbi Adenovirus-mediated gene transfer of interferon alpha improves dimethylnitrosamine-induced liver cirrhosis in rat model
    K Suzuki
    Genetics Division, National Cancer Center Research Institute, Tokyo, Japan
    Gene Ther 10:765-73. 2003
    ..adenovirus vector expressing the rat IFN-alpha gene (AxCA-rIFN) was injected intravenously into rats with dimethylnitrosamine-induced LC...
  41. ncbi Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths
    Sidhartha D Ray
    Division of Pharmaceutical Sciences, Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, NY 11201, USA
    Mutat Res 579:81-106. 2005
    ..and co-exposure of proanthocyanidin-rich grape seed extract (GSPE) in preventing, reducing and/or delaying dimethylnitrosamine (N-nitrosodimethylamine, DMN)-induced liver tumorigenesis, carcinogenesis and mortality in male B6C3F1 mice ..
  42. ncbi Negative correlation between poly-ADP-ribosylation of spleen cell histone proteins and initial duration of dimethylnitrosamine exposure to mice in vivo measured by Western blot immunoprobe assay: a possible biomarker for cancer detection
    Brahmacharimayum J Devi
    Radiation and Molecular Biology Unit, Department of Biochemistry, North Eastern Hill University, Shillong 793022, India
    Cancer Detect Prev 29:66-71. 2005
    ..Swiss albino mice were exposed to hepatocarcinogen, dimethylnitrosamine (DMN), at a chronic dose, which is known to induce carcinogenesis in liver...
  43. ncbi Mineral metabolism in dimethylnitrosamine-induced hepatic fibrosis
    Joseph George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Biochem 39:984-91. 2006
    ..In the present investigation, we have monitored serum and liver concentrations of calcium, magnesium, sodium and potassium during experimentally induced hepatic fibrosis in rats...
  44. ncbi [Inhibitory effects of silymarin on hepatic fibrosis induced by dimethylnitrosamine: experiment with rats]
    Xin Yan Zhao
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China
    Zhonghua Yi Xue Za Zhi 86:2563-6. 2006
    ..To investigate the antifibrotic effects of silymarin on hepatic fibrosis...
  45. ncbi Ascorbic acid concentrations in dimethylnitrosamine-induced hepatic fibrosis in rats
    Joseph George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Madras 600 020, India
    Clin Chim Acta 335:39-47. 2003
    ..In the present investigation, ascorbic acid and lipid peroxides were monitored in the blood and liver samples during the progression of experimentally induced hepatic fibrosis...
  46. ncbi Global gene expression profiling of dimethylnitrosamine-induced liver fibrosis: from pathological and biochemical data to microarray analysis
    Li Jen Su
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 114, Taiwan
    Gene Expr 13:107-32. 2006
    ..Here we used dimethylnitrosamine (DMN), a nongenotoxic hepatotoxin, to induce rat necroinflammatory and hepatic fibrosis...
  47. ncbi Organ variation in the mutagenicity of dimethylnitrosamine in Big Blue mice
    T Suzuki
    Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 28:348-53. 1996
    Organ specificity in the lacI mutant frequency (MF) induced by dimethylnitrosamine (DMN) was analyzed in lung, liver, kidney, bone marrow, urinary bladder, and testis of Big Blue mice...
  48. ncbi Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats
    M Yasuda
    Second Department of Internal Medicine, School of Medicine, University of Tokushima, Tokushima, Japan
    Hepatology 29:719-27. 1999
    ..estradiol, hepatic fibrosis was induced in male and female rats by the administration of a single dose of dimethylnitrosamine (DMN)...
  49. ncbi Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats
    Jae Ho Choi
    Department of Toxicology, College of Pharmacy, Chungnam National University, Gung Dong, Daejeon, Republic of Korea
    Food Chem Toxicol 48:3137-43. 2010
    ..the anthocyanin fraction (AF) obtained from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine (DMN) administration in rats...
  50. ncbi Resveratrol inhibits dimethylnitrosamine-induced hepatic fibrosis in rats
    Eun Sil Lee
    College of Pharmacy, Pusan National University, Busan, Korea
    Arch Pharm Res 33:925-32. 2010
    ..In this study, we investigated the protective effect of resveratrol on hepatic injury induced by dimethylnitrosamine (DMN) in rats...
  51. ncbi Dimethylnitrosamine-induced liver injury in rats: the early deposition of collagen
    J George
    Department of Biochemistry, Central Leather Research Institute, Adyar, Chennai600 020, India
    Toxicology 156:129-38. 2001
    b>Dimethylnitrosamine (DMN) is a potent hepatotoxin that can cause fibrosis of the liver. It's ability to provide a suitable rapid experimental murine model for early human cirrhosis was examined...
  52. ncbi In vivo exposure of swiss albino mice to chronic low dose of dimethylnitrosamine (DMN) lowers poly-ADP-ribosylation (PAR) of bone marrow cell and blood lymphocyte proteins
    L Kma
    Radiation and Molecular Biology Unit, Department of Biochemistry, North Eastern Hill University, Umshing, Shillong, 793022, India
    Mol Cell Biochem 288:143-9. 2006
    ..PAR of bone marrow cell (BMC) and blood lymphocyte (BL) proteins in mice chronically exposed to low dose of dimethylnitrosamine (DMN) for up to four weeks in vivo...
  53. ncbi The protective effect of resveratrol on dimethylnitrosamine-induced liver fibrosis in rats
    Sang Won Hong
    Department of Biomedical Sciences and Clinical Research Center, College of Medicine, Inha University, Incheon, 400 711, Korea
    Arch Pharm Res 33:601-9. 2010
    ..In this study, we investigated the protective effects of resveratrol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats...
  54. ncbi Ultrasonography, biochemical and hematological profiles in liver disease caused by intravenous administration of dimethylnitrosamine in dogs
    T Mwanza
    Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan
    Jpn J Vet Res 45:153-61. 1997
    ..function tests and ultrasonographical findings were analysed in 7 dogs that were intravenously injected dimethylnitrosamine (DMNA 2 mg/kg body weight) on 2 consecutive days each week for 10 weeks...
  55. ncbi [Effects of salvianolic acid B on expressions of TGF-beta1 and its receptors in liver of rats with dimethylnitrosamine-induced hepatic fibrosis]
    Xiao Ning Wang
    Institute of Liver Diseases, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Zhong Xi Yi Jie He Xue Bao 3:286-9. 2005
    ..To study the therapeutic mechanism of salvianolic acid B (SA-B) in treating hepatic fibrosis...
  56. ncbi Hepatoprotective effect of extracts from Lentinus edodes mycelia on dimethylnitrosamine-induced liver injury
    Soichiro Akamatsu
    Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
    Biol Pharm Bull 27:1957-60. 2004
    ..The L.E.M. and ESMe were then examined for their hepatoprotective effect on dimethylnitrosamine-injured mice...
  57. ncbi [The role of hepatic sinusoid capillarization during the formation of portal hypertension in fibrotic rats induced by dimethylnitrosamine]
    Xiong Lu
    Department of Pathology, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China
    Zhonghua Gan Zang Bing Za Zhi 11:595-8. 2003
    To study the role of hepatic sinusoid capillarization during the formation of portal hypertension in fibrotic rats induced by dimethylnitrosamine (DMN).
  58. pmc Effects of excretory/secretory products from Clonorchis sinensis and the carcinogen dimethylnitrosamine on the proliferation and cell cycle modulation of human epithelial HEK293T cells
    Eun Min Kim
    Department of Parasitology and Tropical Medicine, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul 110 799, Korea
    Korean J Parasitol 46:127-32. 2008
    ..In cells exposed to the excretory/secretory products (ESP) of C. sinensis and the carcinogen dimethylnitrosamine (DMN), cellular proliferation and the proportion of cells in the G2/M phase increased...
  59. ncbi Antifibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats
    Yi Chao Hsu
    Institute of Traditional Medicine, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Biomed Sci 12:185-95. 2005
    ..Fibrosis was induced by dimethylnitrosamine (DMN) administration in rats...
  60. ncbi Long-term mutagenicity studies with chloroform and dimethylnitrosamine in female lacI transgenic B6C3F1 mice
    B E Butterworth
    Chemical Industry Institute of Toxicology, Research Triangle Park, North Carolina 27709, USA
    Environ Mol Mutagen 31:248-56. 1998
    ..The positive control, dimethylnitrosamine (DMN) is a DNA-reactive mutagen and carcinogen...
  61. ncbi Esophageal cancer prevention in zinc-deficient rats: rapid induction of apoptosis by replenishing zinc
    L Y Fong
    Department of Microbiology and Immunology, Kimmel Cancer Institute, Thomas Jefferson University, Philadelphia, PA 19107 6799, USA
    J Natl Cancer Inst 93:1525-33. 2001
    ..We investigated whether apoptosis was involved in the reduction of NMBA-induced esophageal tumors when ZD rats consumed a zinc-sufficient diet...
  62. ncbi Mutant frequencies and mutation spectra of dimethylnitrosamine (DMN) at the lacI and cII loci in the livers of Big Blue transgenic mice
    B S Shane
    Institute for Environmental Studies, Louisiana State University, 70803, Baton Rouge, LA 70803, USA
    Mutat Res 452:197-210. 2000
    ..mutational spectrum (MS) of lacI and cII from the same DNA samples isolated from the liver of control and dimethylnitrosamine (DMN)-treated mice. A three-fold (p<0...
  63. ncbi Hepatic lacI and cII mutation in transgenic (lambdaLIZ) rats treated with dimethylnitrosamine
    B B Gollapudi
    The Dow Chemical, Health and Environmental Research Laboratory, 1803 Building, Midland, MI 48674, USA
    Mutat Res 419:131-5. 1998
    ..of the Big Blue(R) rat for the detection of in vivo mutations was investigated by studying spontaneous and dimethylnitrosamine (DMN)-induced hepatic mutations...
  64. pmc An herbal formula, CGX, exerts hepatotherapeutic effects on dimethylnitrosamine-induced chronic liver injury model in rats
    Jang Woo Shin
    East West Cancer Center, Dunsan Oriental Hospital of Oriental medical College of Daejeon University, 1136 Dunsan dong, Seo Gu, Daejeon 302 122, South Korea
    World J Gastroenterol 12:6142-8. 2006
    To evaluate the therapeutic effect of Chunggan extract (CGX), a modified traditional Chinese hepatotherapeutic herbal, on the dimethylnitrosamine (DMN)-induced chronic liver injury model in rats.
  65. ncbi [Effects of corydyceps polysaccharide on liver fibrosis induced by DMN in rats]
    Feng hua Li
    Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Zhongguo Zhong Yao Za Zhi 31:1968-71. 2006
    ..To study the mechanism of Corydyceps polysaccharide (CP) actions against liver fibrosis...
  66. ncbi Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, R3T2N2, Canada
    Biochem Cell Biol 85:189-95. 2007
    ..A rat model of liver fibrosis was established using the dimethylnitrosamine method. Liver tissue and serum were used to examine the effect of SSd on liver fibrosis...
  67. ncbi Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats
    Yun Lian Lin
    National Research Institute of Chinese Medicine, Taipei, Taiwan
    Phytother Res 22:69-76. 2008
    ..Fibrosis was induced in rats by dimethylnitrosamine (DMN) administration for 4 weeks...
  68. ncbi Role of endogenous opioids in modulating HSC activity in vitro and liver fibrosis in vivo
    S De Minicis
    Department of Gastroenterology, Polytechnic University of Marche, Ancona, Italy
    Gut 57:352-64. 2008
    ..Endogenous opioids modulate the growth of nervous and non-nervous cells. Hepatic stellate cells (HSCs) are the main cell phenotype involved in liver fibrogenesis, display molecular markers of neuronal cells and respond to neurotransmitters...
  69. ncbi Preventive effect of fermented brown rice and rice bran on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in rats
    Toshiya Kuno
    Department of Tumor Pathology, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Int J Oncol 25:1809-15. 2004
    ....
  70. ncbi Relationship between the proliferative capability of hepatocytes and the intrahepatic expression of hepatocyte growth factor and c-Met in the course of cirrhosis development in rats
    Hideyuki Inoue
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 17:857-64. 2006
    ..In the present study, liver cirrhosis was produced in rats by intraperitoneally administering dimethylnitrosamine (DMN) and intrahepatic expression levels of HGF and c-Met were quantitatively estimated using a real-time ..
  71. ncbi Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury
    Joseph George
    Division of Molecular Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA
    Clin Chim Acta 348:189-97. 2004
    b>Dimethylnitrosamine (DMN), a potent hepatotoxin, administered to rats, provides a convenient model for toxic liver injury...
  72. ncbi Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses
    Fumihiro Ohara
    St Louis Laboratories, Pfizer Global Research and Development, Chesterfield, MO 63017, USA
    Dig Dis Sci 53:2222-32. 2008
    b>Dimethylnitrosamine administration induces a rapid increase in collagen deposition with concomitant proliferation of hepatic stellate cells in rats...
  73. ncbi Chemopreventive effects of a selective nitric oxide synthase inhibitor on carcinogen-induced rat esophageal tumorigenesis
    Tong Chen
    Division of Environmental Health Sciences, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 64:3714-7. 2004
    ..These observations suggest that iNOS plays a role in tumor development and that its selective inhibitor, PBIT, significantly inhibits esophageal tumor progression presumably through reducing the production of NO...
  74. ncbi Suppression of macrophage infiltration inhibits activation of hepatic stellate cells and liver fibrogenesis in rats
    Michio Imamura
    Department of Biochemistry and Molecular Pathophysiology, University of Occupational and Environmental Health, School of Medicine, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Gastroenterology 128:138-46. 2005
    ....
  75. ncbi Different tumor necrosis factor-alpha-associated leptin expression in rats with dimethylnitrosamine and bile duct ligation-induced liver cirrhosis
    Shih Yi Lin
    Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taiwan
    Metabolism 54:445-52. 2005
    ..Liver cirrhosis was induced in male Sprague-Dawley rats by dimethylnitrosamine (DMN) administration or by common bile duct ligation (BDL)...
  76. ncbi Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 222:11-5. 2005
    ....
  77. ncbi Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine
    Soo K Bae
    College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea
    J Pharm Sci 95:985-97. 2006
    ..once per week at 100 mg/kg/week for 1-3 weeks) oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. The AUC of oltipraz was significantly greater in cirrhotic rats than controls (890 compared with 270 ..
  78. pmc Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun
    Tong Chen
    Cancer Chemoprevention Program, Division of Hematology and Oncology, Department of Internal Medicine, College of Medicine and Public Health, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 66:2853-9. 2006
    ..Prostaglandin E(2) and total nitrite levels were also decreased by BRB in papillomas. These results suggest a novel tumor suppressive role of BRB through inhibition of COX-2, iNOS, and c-Jun...
  79. ncbi Repeated intravenous injection of recombinant human hepatocyte growth factor ameliorates liver cirrhosis but causes albuminuria in rats
    Kazunori Kusumoto
    Department of Internal Medicine II, Faculty of Medicine, University of Miyazaki, Japan
    Int J Mol Med 17:503-9. 2006
    ..its pharmacokinetics and nephrotoxicity in rats with liver cirrhosis induced by 4-week treatment with dimethylnitrosamine (DMN). rh-HGF (0...
  80. ncbi Morphological and serum hyaluronic acid, laminin and type IV collagen changes in dimethylnitrosamine-induced hepatic fibrosis of rats
    Chun Hui Li
    Department of Pathology, Affiliated Hospital of Yanbian University College of Medicine, Yanji 133000, Jilin Province, China
    World J Gastroenterol 11:7620-4. 2005
    To study the morphological and serum hyaluronic acid (HA), laminin (LN), and type IV collagen changes in hepatic fibrosis of rats induced by dimethylnitrosamine (DMN).
  81. ncbi [The dynamic expression of Thy1.1 positive hepatic oval cells during the shaping and reducing processes of liver cirrhosis induced by dimethylnitrosamine in rats]
    Ying Zhu
    Shanghai University of Traditional Chinese Medicine, Liver Diseases Institute, Shanghai 201203, China
    Zhonghua Gan Zang Bing Za Zhi 13:823-7. 2005
    To study the dynamic change of hepatic oval cells (HOC) in the process of rat liver cirrhosis formation induced by dimethylnitrosamine (DMN), and to explore its pathophysiology significance.
  82. ncbi [Effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats]
    Feng hua Li
    Institute of Liver Diseases, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    Zhong Xi Yi Jie He Xue Bao 4:514-7. 2006
    To study the effects of Cordyceps sinensis on dimethylnitrosamine-induced liver fibrosis in rats.
  83. ncbi Cell cycle protein profile of the hepatic stellate cells(HSCs)in dimethylnitrosamine-induced rat hepatic fibrosis
    Mi Rhan Kim
    Department of Pathology, Seoul National University, College of Medicine, 28 Yongon Dong, Jongro Gu, Seoul 110 799, Korea
    Exp Mol Med 37:335-42. 2005
    ..001). The increase of cyclin A, and PCNA and the decrease of p21(Cip/WAF1) seem to play important roles in the proliferation of HSCs during the early period of DMN treatment...
  84. ncbi siRNA-mediated knockdown of connective tissue growth factor prevents N-nitrosodimethylamine-induced hepatic fibrosis in rats
    J George
    Department of Medicine, Division of Molecular Medicine, Columbia University, New York, NY, USA
    Gene Ther 14:790-803. 2007
    ..induced hepatic fibrosis in rats through serial intraperitoneal injections of N-nitrosodimethylamine (NDMA; dimethylnitrosamine, DMN) and studied the upregulation of CTGF and TGF-beta1 during hepatic fibrogenesis...
  85. ncbi The effects of L-748706, a selective cyclooxygenase-2 inhibitor, on N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Gary D Stoner
    Cancer Chemoprevention and Support Program, Division of Hematology and Oncology, College of Medicine and Public Health, The Ohio State University, Columbus, OH 43210, USA
    Carcinogenesis 26:1590-5. 2005
    ....
  86. ncbi Increased iron deposition in rat liver fibrosis induced by a high-dose injection of dimethylnitrosamine
    Limei Guo
    Department of Pathology, School of Medicine, Kochi University, Kochi, Japan
    Exp Mol Pathol 81:255-61. 2006
    ..rat model of hepatic necrosis and subsequent fibrosis induced by a high-dose intraperitoneal injection of dimethylnitrosamine (DMN), we studied iron deposition and expression of transforming growth factor-beta(1) (TGF-beta(1)) during ..
  87. ncbi Differential regulation of protein S expression in hepatocytes and sinusoidal endothelial cells in rats with cirrhosis
    K Fujii
    Department of Molecular Pathobiology, Mie University Graduate School of Medicine, Tsu City, Japan
    J Thromb Haemost 4:2607-15. 2006
    ..Liver dysfunction caused by intrasinusoidal microthrombi is frequently observed in patients with cirrhosis after hepatectomy, but the mechanistic pathway remains unknown...
  88. ncbi Inhibitory effects of idoxifene on hepatic fibrosis in rats
    Ya jun Zhou
    Department of Biochemistry and Molecular Biology, Medical College, Nan Tong University, Nantong 226001, China
    Acta Pharmacol Sin 26:581-6. 2005
    ..To investigate the effects of a tissue-specific selective estrogen receptor modulator, idoxifene, on hepatic fibrosis in rats...
  89. ncbi Proliferative capability of hepatocytes and expression of G1-related cell cycle molecules in the development of liver cirrhosis in rats
    Fumi Funakoshi
    Third Department of Internal Medicine, Kagawa University School of Medicine, Miki cho, Kita gun, Kagawa 761 0793, Japan
    Int J Mol Med 13:779-87. 2004
    ..In the present study, liver cirrhosis was produced in rats by intraperitoneally administering dimethylnitrosamine (DMN)...
  90. ncbi [Suppressive effects of antioxidant DA-9601 on hepatic fibrosis in rats]
    Jae Youn Cheong
    Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea
    Taehan Kan Hakhoe Chi 8:436-47. 2002
    ..We tried to evaluate whether antioxidant can ameliorate dimethylnitrosamine (DMN)-induced hepatic fibrosis.
  91. ncbi Experimental studies on morphological changes of microcirculation of DMN-induced liver cirrhosis after normothermic ischemia with charge-coupled device microscope
    Tsuyoshi Shimamoto
    First Department of Surgery, Gifu University School of Medicine, 40 Tsukasa Machi, Gifu City, Gifu 500 8705, Japan
    J Gastroenterol Hepatol 18:1071-5. 2003
    ..The purpose of the present experiment was to find indices for intraoperative ischemic-reperfusion injury in the cirrhotic liver...
  92. ncbi Perillyl alcohol as a chemopreventive agent in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis
    Beth W Liston
    Department of Pathology, School of Public Health and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA
    Cancer Res 63:2399-403. 2003
    ..These data indicate that POH has a weakly promoting effect early in nitrosamine-induced esophageal tumorigenesis and suggest that POH may not be an effective chemopreventive agent for esophageal cancer in humans...
  93. ncbi L-cysteine administration prevents liver fibrosis by suppressing hepatic stellate cell proliferation and activation
    Takashi Horie
    Pharmaceuticals Research Laboratories, Ajinomoto Co, Inc, 1 1, Suzuki cho, Kawasaki ku, Kawasaki 210 8681, Japan
    Biochem Biophys Res Commun 305:94-100. 2003
    ..These findings suggest that L-cysteine is effective against liver fibrosis. The mechanism of inhibition of fibrosis in the liver is surmized to be direct inhibition of activated HSC proliferation and HSC transformation by L-cysteine...
  94. ncbi Promotion effects of hot water on N-nitrosomethylbenzylamine-induced esophageal tumorigenesis in F344 rats
    Zhi Gang Li
    Department of Surgery and Surgical Basic Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Oncol Rep 10:421-6. 2003
    ..Our study further confirmed that the drinking of hot beverages increased the risk of esophageal carcinogenesis, and the drinking hot tea will abolish the inhibitory effects of EGCG on this disease...
  95. ncbi Tissue remodeling following submassive hemorrhagic necrosis in rat livers induced by an intraperitoneal injection of dimethylnitrosamine
    Yu Lan Jin
    First Department of Pathology, Kochi Medical School, Kohasu, Oko cho, Nankoku City, Kochi, 783 8505, Japan
    Virchows Arch 442:39-47. 2003
    ..Acute hepatic injury was induced in rats by administration of an intraperitoneal injection of high-dose dimethylnitrosamine (50 mg/kg body weight)...
  96. ncbi Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis
    Masahiro Kaneko
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Oncol Rep 9:1069-73. 2002
    ..These data suggest that simultaneous ethanol administration have weak enhancing effects, and also promoting effects in post-initiation phase is present on NMBA-induced rat tumorigenesis...
  97. ncbi Incidence and effects of Ha-ras codon 12 G-->A transition mutations in preneoplastic lesions induced by N-nitrosomethylbenzylamine in the rat esophagus
    B W Liston
    Department of Pathology, Ohio State University, Columbus, Ohio 43210, USA
    Mol Carcinog 32:1-8. 2001
    ....
  98. ncbi Selective Na+/H+ exchange inhibition by cariporide reduces liver fibrosis in the rat
    Antonio Di Sario
    Department of Gastroenterology, University of Ancona, Italy
    Hepatology 37:256-66. 2003
    ..Rats treated with dimethylnitrosamine (DMN; 10 mg/kg) for 1 and 5 weeks received a diet with or without 6 ppm cariporide...
  99. ncbi Effect of ethanol treatment on metabolic activation and detoxification of esophagus carcinogenic N-nitrosamines in rat liver
    Yukio Mori
    Laboratory of Radiochemistry, Gifu Pharmaceutical University, 6 1, Mitahora higashi 5 chome, Gifu 502 8585, Japan
    Mutagenesis 17:251-6. 2002
    ....
  100. ncbi Expression of hepatocyte growth factor mRNA in rat liver cirrhosis induced by N-nitrosodimethylamine as evidenced by in situ RT-PCR
    Junko Hata
    Safety Research Department, Pharmaceuticals Development Research Laboratories, Teijin Limited, Tokyo, Japan
    J Histochem Cytochem 50:1461-8. 2002
    ..Our results confirmed that expression of TGF-beta mRNA co-localized with HGF mRNA expression in the cirrhotic liver...
  101. ncbi Effects of extract derived from Eriobotrya japonica on liver function improvement in rats
    Yutaka Nishioka
    Department of Pharmacy, Kochi Medical School Hospital, Japan
    Biol Pharm Bull 25:1053-7. 2002
    ..The seed extracts were orally administered to rats with dimethylnitrosamine-induced hepatopathy, and blood L-asparate aminotransferase (AST) and L-alanine aminotransferase (ALT) ..

Research Grants26

  1. FORMATION AND METABOLISM OF NITROSAMINES IN PIGS
    Peter Magee; Fiscal Year: 1991
    ..The project has four specific aims: (1) To study the pharmacokinetics and metabolism of dimethylnitrosamine in pigs and to measure the extents of methylation of DNA of various organs and of blood proteins...
  2. ION DEREGULATION IN VIVO AND INJURY BY ALKYLATING DRUGS
    George Corcoran; Fiscal Year: 1990
    ..trace how indicators change in vivo during rodent liver injury by a panel of hepatotoxins (ACETAMINOPHEN, DIMETHYLNITROSAMINE, ALLYL ALCOHOL, D- GALACTOSAMINE) designed to distinguish specific molecular consequences of alkylation and ..
  3. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1991
    ..cytochrome P-450 (P-450LM/3A) and results in a substantial increase in the metabolism of alcohol(s), dimethylnitrosamine and pyridine to the pyridine-N- oxide product...
  4. TRANSGENIC FISH MODELS FOR MUTAGENESIS STUDIES
    Richard Winn; Fiscal Year: 2004
    ..shown to induce retinoblastomas, and test the inhibitory effects of green tea on mutations caused by dimethylnitrosamine and benzo[a]pyrene exposure...
  5. PROGRESSION OF HEPATIC NEOPLASIA BY PCB/ARSENIC MIXTURES
    JON PAINTER; Fiscal Year: 2004
    ..153 will be evaluated using a 26-week in vivo initiation/promotion/progression (IPP) assay in the rat using dimethylnitrosamine (DEN) initiation, partial hepatectomy, and subchronic PCB mixture treatment...
  6. EXCRETED ALKYL PURINES AS MARKERS OF IN VIVO DNA DAMAGE
    David Shuker; Fiscal Year: 1990
    ..be correlated with methylation in both lymphocyte DNA and target tissue DNA following administration of dimethylnitrosamine. Similar experiments will be carried out for the urinary 3-ethyladenine and and 7-ethylguanine following ..
  7. RIBONUCLEOPROTEIN COMPLEXES IN RENAL CARCINOMA
    David Irwin; Fiscal Year: 1980
    ..will be produced by contralateral nephrectomy, hyperplasia by injection of folic acid, and neoplasia by dimethylnitrosamine treatment of Charles River mice...
  8. CHEMICAL CARCINOGENESIS IN THE ATHYMIC MOUSE
    Lucy Anderson; Fiscal Year: 1980
    ..nudes will involve chronic, oral administration of a low dose of an environmental nitrosamine carcinogen, dimethylnitrosamine. Data published thus far from several laboratories has indicated that nudes do not differ from normal mice ..
  9. MECHANISMS FOR TNF ALPHA IN XENOBIOTIC LIVER INJURY
    Mark Rutherford; Fiscal Year: 2000
    ..Preliminary studies support that TNF-alpha may play a role in dimethylnitrosamine (DMN) toxicity as well...
  10. SOLID-PHASE ELECTROPHILE TRAPPING AGENTS
    Thomas Curphey; Fiscal Year: 1992
    ..The new agents will be applied to study of metabolism of dimethylnitrosamine, since there are conflicting reports of the ability of the usual thiol nucleophile, 2,4-..
  11. MUTAGENESIS BY CHEMICAL CARCINOGENS
    BRADLEY PRESTON; Fiscal Year: 1992
    ..Finally, the mutagenicities of the hepatocarcinogenic alkylating agents, dimethylnitrosamine (DMN) and diethynitrosamine (DEN), will be examined...
  12. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  13. 2006 Drinking Water Disinection By-Product (DBP) Gordon Conference
    Susan Richardson; Fiscal Year: 2006
    ..Issues to be covered include new reproductive/developmental toxicological issues, human exposure, chemistry of formation, and remaining cancer issues. [unreadable] [unreadable] [unreadable] [unreadable]..
  14. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  15. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  16. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  17. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  18. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  19. DLPC Treatment of Alcoholic and Non-Alcoholic Fibrosis
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  20. ENDOGENOUS NITROSATION CHEMISTRY IN CARCINOGENESIS
    RICHARD LOEPPKY; Fiscal Year: 2004
    ..Computational methods will be employed to reveal reaction paths of intermediates and lead to better predictions of the types of compounds which pose a carcinogenic threat through their endogenous nitrosation. ..
  21. MECHANISM AND ROLE OF MICROSOMAL ETHANOL OXIDATION
    Charles Lieber; Fiscal Year: 2001
    ..Such information is aimed at elucidating key aspects of alcohol mediated pathology in a way which may eventually affect alcohol related medical complications, their prevention and treatment. ..
  22. CARCINOGENESIS--HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 2001
    ....
  23. Role of O6-alkylguanine in nitrosamine-induced cancers
    Lisa Peterson; Fiscal Year: 2009
    ..These studies will set the stage for a molecular epidemiological study to determine whether individuals who are unable to repair this mutagenic adduct are at increased risk of tobacco-related cancers. ..