nitro compounds

Summary

Top Publications

  1. ncbi A common pesticide decreases foraging success and survival in honey bees
    Mickaël Henry
    Institut National de la Recherche Agronomique, UR406 Abeilles et Environnement, F 84914 Avignon, France
    Science 336:348-50. 2012
  2. ncbi Neonicotinoid pesticide reduces bumble bee colony growth and queen production
    Penelope R Whitehorn
    School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK
    Science 336:351-2. 2012
  3. pmc Interactions between Nosema microspores and a neonicotinoid weaken honeybees (Apis mellifera)
    Cedric Alaux
    INRA, UMR 406 Abeilles et Environnement, Laboratoire Biologie et Protection de l abeille, Site Agroparc, 84914 Avignon, France
    Environ Microbiol 12:774-82. 2010
  4. ncbi Applied aspects of neonicotinoid uses in crop protection
    Alfred Elbert
    Bayer CropScience, Development, Agronomic Development, Alfred Nobel Strasse 50, D 40789 Monheim, Germany
    Pest Manag Sci 64:1099-105. 2008
  5. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
  6. ncbi A meta-analysis of experiments testing the effects of a neonicotinoid insecticide (imidacloprid) on honey bees
    James E Cresswell
    School of Biosciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter, EX4 4PS, UK
    Ecotoxicology 20:149-57. 2011
  7. pmc Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
    Dorothee Stanneck
    Bayer Animal Health GmbH BAH, Monheim, Germany
    Parasit Vectors 5:66. 2012
  8. ncbi Detections of the neonicotinoid insecticide imidacloprid in surface waters of three agricultural regions of California, USA, 2010-2011
    Keith Starner
    California Department of Pesticide Regulation, Environmental Monitoring Branch, 1001 I Street, Sacramento, CA 95812, USA
    Bull Environ Contam Toxicol 88:316-21. 2012
  9. pmc Pesticide exposure in honey bees results in increased levels of the gut pathogen Nosema
    Jeffery S Pettis
    USDA ARS Bee Research Laboratory, Beltsville, MD, USA
    Naturwissenschaften 99:153-8. 2012
  10. ncbi Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
    Nathan J Moerke
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:257-67. 2007

Detail Information

Publications273 found, 100 shown here

  1. ncbi A common pesticide decreases foraging success and survival in honey bees
    Mickaël Henry
    Institut National de la Recherche Agronomique, UR406 Abeilles et Environnement, F 84914 Avignon, France
    Science 336:348-50. 2012
    ..These experiments offer new insights into the consequences of common neonicotinoid pesticides used worldwide...
  2. ncbi Neonicotinoid pesticide reduces bumble bee colony growth and queen production
    Penelope R Whitehorn
    School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK
    Science 336:351-2. 2012
    ..Given the scale of use of neonicotinoids, we suggest that they may be having a considerable negative impact on wild bumble bee populations across the developed world...
  3. pmc Interactions between Nosema microspores and a neonicotinoid weaken honeybees (Apis mellifera)
    Cedric Alaux
    INRA, UMR 406 Abeilles et Environnement, Laboratoire Biologie et Protection de l abeille, Site Agroparc, 84914 Avignon, France
    Environ Microbiol 12:774-82. 2010
    ..This provides the first evidences that interaction between an infectious organism and a chemical can also threaten pollinators, interactions that are widely used to eliminate insect pests in integrative pest management...
  4. ncbi Applied aspects of neonicotinoid uses in crop protection
    Alfred Elbert
    Bayer CropScience, Development, Agronomic Development, Alfred Nobel Strasse 50, D 40789 Monheim, Germany
    Pest Manag Sci 64:1099-105. 2008
    ..These innovative developments for life-cycle management, jointly with the introduction of generic products, will, within the next few years, turn neonicotinoids into the most important chemical class in crop protection...
  5. pmc The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats
    Dorothee Stanneck
    Bayer Animal Health GmbH, Leverkusen, Germany
    Parasit Vectors 5:73. 2012
    ..A new polymer matrix collar has recently been developed which is registered for 8 months use in cats and dogs. The basic properties of this collar have been investigated in several in vitro and in vivo studies...
  6. ncbi A meta-analysis of experiments testing the effects of a neonicotinoid insecticide (imidacloprid) on honey bees
    James E Cresswell
    School of Biosciences, University of Exeter, Hatherly Laboratories, Prince of Wales Road, Exeter, EX4 4PS, UK
    Ecotoxicology 20:149-57. 2011
    ....
  7. pmc Evaluation of the long-term efficacy and safety of an imidacloprid 10%/flumethrin 4.5% polymer matrix collar (Seresto®) in dogs and cats naturally infested with fleas and/or ticks in multicentre clinical field studies in Europe
    Dorothee Stanneck
    Bayer Animal Health GmbH BAH, Monheim, Germany
    Parasit Vectors 5:66. 2012
    ....
  8. ncbi Detections of the neonicotinoid insecticide imidacloprid in surface waters of three agricultural regions of California, USA, 2010-2011
    Keith Starner
    California Department of Pesticide Regulation, Environmental Monitoring Branch, 1001 I Street, Sacramento, CA 95812, USA
    Bull Environ Contam Toxicol 88:316-21. 2012
    ..The results indicate that imidacloprid commonly moves offsite and contaminates surface waters at concentrations that could harm aquatic organisms following use under irrigated agriculture conditions in California...
  9. pmc Pesticide exposure in honey bees results in increased levels of the gut pathogen Nosema
    Jeffery S Pettis
    USDA ARS Bee Research Laboratory, Beltsville, MD, USA
    Naturwissenschaften 99:153-8. 2012
    ..Interactions between pesticides and pathogens could be a major contributor to increased mortality of honey bee colonies, including colony collapse disorder, and other pollinator declines worldwide...
  10. ncbi Small-molecule inhibition of the interaction between the translation initiation factors eIF4E and eIF4G
    Nathan J Moerke
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
    Cell 128:257-67. 2007
    ..The identification of this compound provides a new tool for studying translational control and establishes a possible new strategy for cancer therapy...
  11. ncbi Lethal effect of imidacloprid on the coccinellid predator Serangium japonicum and sublethal effects on predator voracity and on functional response to the whitefly Bemisia tabaci
    Yuxian He
    Institute of Plant Protection, Fujian Academy of Agricultural Sciences, Fuzhou 350013, People s Republic of China
    Ecotoxicology 21:1291-300. 2012
    ..These results hint at the importance of assessing potential effects of imidacloprid on S. japonicum for developing effective integrated pest management programs of B. tabaci in China...
  12. pmc Use of an innovative T-tube maze assay and the proboscis extension response assay to assess sublethal effects of GM products and pesticides on learning capacity of the honey bee Apis mellifera L
    Peng Han
    College of Plant Science and Technology, Hubei Key Laboratory of Utilization of Insect Resources and Sustainable Control of Pests, Huazhong Agricultural University, Shizi Mountain Road, Wuhan 430070, China
    Ecotoxicology 19:1612-9. 2010
    ..The implications of these results are discussed in terms of risks of transgenic CCRI41 cotton crops for honey bees...
  13. pmc Neonicotinoids in bees: a review on concentrations, side-effects and risk assessment
    Tjeerd Blacquière
    Plant Research International, Wageningen University and Research, Wageningen, The Netherlands
    Ecotoxicology 21:973-92. 2012
    ..Molecular markers may be used to improve risk assessment by a better understanding of the mode of action (interaction with receptors) of neonicotinoids in bees leading to the identification of environmentally safer compounds...
  14. pmc RFID tracking of sublethal effects of two neonicotinoid insecticides on the foraging behavior of Apis mellifera
    Christof W Schneider
    Institut für Bienenkunde, Department of Biological Science, Goethe University, Frankfurt am Main, Germany
    PLoS ONE 7:e30023. 2012
    ..We contribute further information on the understanding of how honeybees are affected by sublethal doses of insecticides...
  15. ncbi Neonicotinoid insecticide toxicology: mechanisms of selective action
    Motohiro Tomizawa
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Annu Rev Pharmacol Toxicol 45:247-68. 2005
    ..The low affinity of neonicotinoids for vertebrate relative to insect nicotinic receptors is a major factor in their favorable toxicological profile...
  16. ncbi Efficacy of a combination of 10% imidacloprid/50% permethrin for the prevention of leishmaniasis in kennelled dogs in an endemic area
    Domenico Otranto
    Department of Animal Health and Welfare, Faculty of Veterinary Medicine, University of Bari, Str Prov per Casamassima Km3, 70010 Valenzano Bari, Italy
    Vet Parasitol 144:270-8. 2007
    ..01). The results clearly show that a combination of imidacloprid 10% and permethrin 50%, by virtue of its repellent activity against sandflies, is effective under both application regimes in preventing CanL in the field in endemic areas...
  17. ncbi New risk assessment approach for systemic insecticides: the case of honey bees and imidacloprid (Gaucho)
    Marie Pierre Halm
    Centre d Etude et de Recherche du Médicament de Normandie, 5 rue Vaubenard, 14032 Caen, France
    Environ Sci Technol 40:2448-54. 2006
    ..These data are discussed in the light of field observations made on honey bee mortalities and disappearances. New perspectives are given to better determine the risk posed by systemic insecticides to honey bees...
  18. ncbi Statistical analysis of honeybee survival after chronic exposure to insecticides
    François Xavier Dechaume Moncharmont
    Laboratoire de Neurobiologie Comparée des Invertébrés, BP23, 91440 Bures sur Yvette, France
    Environ Toxicol Chem 22:3088-94. 2003
    ..None of these parameters can be neglected in the assessment of chronic toxicity of pesticides to the honeybee...
  19. ncbi Discrepancy between acute and chronic toxicity induced by imidacloprid and its metabolites in Apis mellifera
    S Suchail
    INRA, Laboratoire de Toxicologie Environnementale, , Avignon, France
    Environ Toxicol Chem 20:2482-6. 2001
    ..For all products tested, bee mortality was induced only 72 h after the onset of intoxication...
  20. ncbi Distribution of [(14)C]imidacloprid in sunflowers (Helianthus annuus L.) following seed treatment
    François M Laurent
    INRA, UMR Xenobiotiques, B P 3, 180 chemin de Tournefeuille, 31931 Toulouse Cedex 9, France
    J Agric Food Chem 51:8005-10. 2003
    ..In pollen, concentrations of imidacloprid were 13 ng x g(-1). Thus, imidacloprid residues from Gaucho seed treatment contaminated sunflower pollen, involving the translocation of imidacloprid within the plant...
  21. ncbi Over-expression of cytochrome P450 CYP6CM1 is associated with high resistance to imidacloprid in the B and Q biotypes of Bemisia tabaci (Hemiptera: Aleyrodidae)
    Iris Karunker
    Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
    Insect Biochem Mol Biol 38:634-44. 2008
    ..tabaci, and the CYP6CM1 gene as a leading target for DNA-based screening for resistance to imidacloprid and possibly other neonicotinoids in field populations...
  22. ncbi Biotype and insecticide resistance status of the whitefly Bemisia tabaci from China
    Zhenyu Wang
    College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects Ministry of Agriculture of China, Nanjing 210095, China
    Pest Manag Sci 66:1360-6. 2010
    ..Resistance to numerous insecticide classes in Bemisia tabaci Gennadius has impaired field control efficacy in south-eastern China. The biotype and resistance status of B. tabaci collected from these areas was investigated...
  23. ncbi Effects of imidacloprid and deltamethrin on associative learning in honeybees under semi-field and laboratory conditions
    Axel Decourtye
    Laboratoire de Neurobiologie Comparée des Invertébrés, INRA, BP 23, 91440 Bures sur Yvette, France
    Ecotoxicol Environ Saf 57:410-9. 2004
    ....
  24. ncbi 3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease
    Emmanuel Brouillet
    Centre Nationale de la Recherche Scientifique 2210, Service Hospitalier Frederic Joliot, Départment de Recherches Médicales, Direction des Sciences du Vivant, CEA, Orsay France
    J Neurochem 95:1521-40. 2005
    ..Research on 3NP provides additional proof that the neurochemical environment of a given neurone can determine its preferential vulnerability in neurodegenerative diseases...
  25. ncbi A LC/APCI-MS/MS method for analysis of imidacloprid in soils, in plants, and in pollens
    J M Bonmatin
    Centre de Biophysique Moleculaire, CNRS and Université Orléans, France
    Anal Chem 75:2027-33. 2003
    ..This explains that pollens from these crops are contaminated at levels of a few micrograms per kilogram, suggesting probable deleterious effects on honeybees...
  26. ncbi Translocation of neonicotinoid insecticides from coated seeds to seedling guttation drops: a novel way of intoxication for bees
    V Girolami
    Dipartimento di Agronomia Ambientale e Produzioni Vegetali, Entomologia, Universita di Padova, Viale dell Universita 16, 35020 Legnaro, Padova, Italy
    J Econ Entomol 102:1808-15. 2009
    ..When bees consume guttation drops, collected from plants grown from neonicotinoid-coated seeds, they encounter death within few minutes...
  27. ncbi The insecticide imidacloprid is a partial agonist of the nicotinic receptor of honeybee Kenyon cells
    Patrice Déglise
    Laboratoire de Neurobiologie de l Insecte, Universite Paul Sabatier, 118 route de Narbonne, F 31062 Toulouse, France
    Neurosci Lett 321:13-6. 2002
    ..Our results identify the honeybee nAChR as a target of imidacloprid and an imidacloprid-induced inhibition of the insect GABA receptor...
  28. pmc Atomic interactions of neonicotinoid agonists with AChBP: molecular recognition of the distinctive electronegative pharmacophore
    Todd T Talley
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, CA 99093 0657, USA
    Proc Natl Acad Sci U S A 105:7606-11. 2008
    ..This template defines the association of interacting amino acids and their energetic contributions to the distinctive interactions of neonicotinoids...
  29. ncbi Abnormal foraging behavior induced by sublethal dosage of imidacloprid in the honey bee (Hymenoptera: Apidae)
    E C Yang
    Department of Entomology, National Chung Hsing University, Taichung, Taiwan
    J Econ Entomol 101:1743-8. 2008
    ..Returning bees also showed delay in their return trips. Our results demonstrated that sublethal dosages of imidacloprid were able to affect foraging behavior of honey bees...
  30. ncbi Efficacy of dinotefuran-pyriproxyfen, dinotefuran-pyriproxyfen-permethrin and fipronil-(S)-methoprene topical spot-on formulations to control flea populations in naturally infested pets and private residences in Tampa, FL
    Michael W Dryden
    Dept of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS, USA
    Vet Parasitol 182:281-6. 2011
    ..24% and 95.47%, respectively. Flea numbers in the indoor-premises were also markedly reduced by days 54-60, with 98.05% and 96.15% reductions in intermittent-light flea trap counts in the DP-DPP or FM treatment groups, respectively...
  31. ncbi Risk assessment for side-effects of neonicotinoids against bumblebees with and without impairing foraging behavior
    Veerle Mommaerts
    Laboratory of Cellular Genetics, Department of Biology, Faculty of Sciences, Free University of Brussels, Brussels, Belgium
    Ecotoxicology 19:207-15. 2010
    ....
  32. ncbi Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: possible behavioural, biochemical and cellular alterations
    Puneet Kumar
    Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India
    Eur J Pharmacol 615:91-101. 2009
    ..The results show that rivastigmine could be used as an effective therapeutic agent in the management of Huntington's disease and related conditions...
  33. ncbi Neonicotinoid insecticides display partial and super agonist actions on native insect nicotinic acetylcholine receptors
    Laurence A Brown
    Department of Physiology, Anatomy and Genetics, MRC Functional Genetics Unit, Le Gros Clark Building, University of Oxford, South Parks Road, Oxford, UK
    J Neurochem 99:608-15. 2006
    ..Cell-attached recordings indicate that super agonism results from more frequent openings at the largest (63.5 pS) conductance state observed...
  34. ncbi N-Acetylcysteine reverses mitochondrial dysfunctions and behavioral abnormalities in 3-nitropropionic acid-induced Huntington's disease
    Rajat Sandhir
    Department of Biochemistry, Panjab University, Chandigarh, India
    Neurodegener Dis 9:145-57. 2012
    ..NAC treatment, on the other hand, was found to be effective in reversing 3-NP-induced mitochondrial dysfunctions and neurobehavioral deficits. Our findings suggest a beneficial effect of NAC in HD...
  35. ncbi Differential sensitivity of honey bees and bumble bees to a dietary insecticide (imidacloprid)
    James E Cresswell
    Biosciences, College of Life and Environmental Sciences, University of Exeter, Geoffrey Pope Building, Stocker Road, Exeter EX4 4QD, United Kingdom
    Zoology (Jena) 115:365-71. 2012
    ....
  36. pmc Prophylactic treatment of flea-infested cats with an imidacloprid/flumethrin collar to forestall infection with Dipylidium caninum
    Josephus J Fourie
    ClinVet International, Universitas 9321, South Africa
    Parasit Vectors 5:151. 2012
    ..5% flumethrin (w/w) incorporated in a slow-release matrix collar in preventing Dipylidium caninum infection in cats following repeated laboratory-infestations with fleas infected with metacestodes...
  37. pmc Diverse actions and target-site selectivity of neonicotinoids: structural insights
    Kazuhiko Matsuda
    Department of Applied Biological Chemistry, School of Agriculture, Kinki University, Nara, Japan
    Mol Pharmacol 76:1-10. 2009
    ..The prospects of designing neonicotinoids that are safe not only for mammals but also for beneficial insects such as honey bees (Apis mellifera) are discussed in terms of interactions with non-alpha nAChR subunits...
  38. ncbi Comparative efficacy of imidacloprid, selamectin, fipronil-(S)-methoprene, and metaflumizone against cats experimentally infested with Ctenocephalides felis
    T Schnieder
    University of Veterinary Medicine Hannover, Bunteweg 17, Hannover, Germany
    Vet Ther 9:176-83. 2008
    ..7% to 67.4% in the other treatment groups. A single topical application of imidacloprid provided a high efficacy in the early elimination of adult fleas, limiting the risk of pathogen transmission and flea allergy dermatitis...
  39. ncbi In vivo distribution and metabolisation of 14C-imidacloprid in different compartments of Apis mellifera L
    Séverine Suchail
    INRA, Laboratoire de Toxicologie Environnementale, UMR 406 INRA UAPV Ecologie des invertébrés, Site Agroparc, 84914 Avignon Cedex 9, France
    Pest Manag Sci 60:1056-62. 2004
    ..These results explain the prolongation of imidacloprid action in bees, and particularly the differences between rapid intoxication symptoms and late mortality...
  40. ncbi Effects of imidacloprid metabolites on habituation in honeybees suggest the existence of two subtypes of nicotinic receptors differentially expressed during adult development
    D Guez
    Visual Sciences, Research School of Biological Sciences, Australian National University, Canberra, ACT 0200, Australia
    Pharmacol Biochem Behav 75:217-22. 2003
    ..The implications of this finding for the honeybee biology are discussed...
  41. ncbi Experimental study on the toxicity of imidacloprid given in syrup to honey bee (Apis mellifera) colonies
    Jean Paul Faucon
    AFSSA, Les Templiers, 105 route des Chappes, BP 111 F 06 902 Sophia Antipolis Cedex, France
    Pest Manag Sci 61:111-25. 2005
    ....
  42. ncbi Neonicotinoid metabolism: compounds, substituents, pathways, enzymes, organisms, and relevance
    John E Casida
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    J Agric Food Chem 59:2923-31. 2011
    ..These relationships explain much of neonicotinoid comparative toxicology and provide the basis for continued and improved safety and effectiveness of this chemotype...
  43. ncbi Cross-resistance, inheritance and biochemical mechanisms of imidacloprid resistance in B-biotype Bemisia tabaci
    Zhenyu Wang
    Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects Ministry of Agriculture, College of Plant Protection, Nanjing Agricultural University, Nanjing, People s Republic of China
    Pest Manag Sci 65:1189-94. 2009
    ..Imidacloprid resistance in a laboratory-selected strain of B-type B. tabaci was characterised in order to provide the basis for recommending resistance management tactics...
  44. ncbi Rapid analysis of neonicotinoid insecticides in guttation drops of corn seedlings obtained from coated seeds
    Andrea Tapparo
    Universita degli Studi di Padova, Dipartimento di Scienze Chimiche, Via Marzolo 1, 35131 Padova, Italy
    J Environ Monit 13:1564-8. 2011
    ....
  45. pmc Efficacy of an imidacloprid/flumethrin collar against fleas, ticks, mites and lice on dogs
    Dorothee Stanneck
    Bayer HealthCare AG, Animal Health Division, 51368 Leverkusen, Germany
    Parasit Vectors 5:102. 2012
    ....
  46. ncbi Current status of insecticide resistance in Q biotype Bemisia tabaci populations from Crete
    Emmanouil Roditakis
    National Agricultural Research Foundation, Plant Protection Institute of Heraklion, PO BOX 2228, 71003 Heraklion, Greece
    Pest Manag Sci 65:313-22. 2009
    ..The aim of this study was to investigate the establishment of resistance and the underlying mechanisms to major insecticide classes with classical bioassays and known biochemical resistance markers...
  47. ncbi Metabolism of imidacloprid in Apis mellifera
    Séverine Suchail
    INRA, UMR 406 INRA UAPV Ecologie des invertébrés, Site Agroparc, 84914 Avignon Cedex 9, France
    Pest Manag Sci 60:291-6. 2004
    ..Thus, 5-hydroxyimidacloprid and olefin could not be the major metabolites in the worker bees...
  48. ncbi Toxicity and nicotinic acetylcholine receptor interaction of imidacloprid and its metabolites in Apis mellifera (Hymenoptera: Apidae)
    R Nauen
    Bayer AG, Agrochemicals Division, Research Insecticides, Building 6220, D 51368 Leverkusen, Germany
    Pest Manag Sci 57:577-86. 2001
    ..The electrophysiological data revealed Hill coefficients of approximately 1, indicating a single binding site responsible for an activation of the receptor and no direct cooperativity or allosteric interaction with a second binding site...
  49. ncbi Cross-resistance study and biochemical mechanisms of thiamethoxam resistance in B-biotype Bemisia tabaci (Hemiptera: Aleyrodidae)
    Yuntao Feng
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, PR China
    Pest Manag Sci 66:313-8. 2010
    ..tabaci, a resistant strain was selected in the laboratory. Cross-resistance and the biochemical mechanisms of thiamethoxam resistance were investigated in the present study...
  50. pmc Mutation of a nicotinic acetylcholine receptor β subunit is associated with resistance to neonicotinoid insecticides in the aphid Myzus persicae
    Chris Bass
    Centre for Sustainable Pest and Disease Management, Rothamsted Research, Harpenden, AL5 2JQ, UK
    BMC Neurosci 12:51. 2011
    ..In this study, a clone of M. persicae collected from southern France was found, for the first time, to exhibit sufficiently strong resistance to result in loss of the field effectiveness of neonicotinoids...
  51. ncbi Mitochondrial dysfunction, metabolic deficits, and increased oxidative stress in Huntington's disease
    Chiung Mei Chen
    Department of Neurology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan
    Chang Gung Med J 34:135-52. 2011
    ....
  52. ncbi DDT resistance in Drosophila correlates with Cyp6g1 over-expression and confers cross-resistance to the neonicotinoid imidacloprid
    P Daborn
    Department of Biology and Biochemistry, University of Bath, Bath, BA2 7AY, UK
    Mol Genet Genomics 266:556-63. 2001
    ..We are now testing the hypothesis that resistance to both compounds is associated with over-expression of this P450 gene...
  53. ncbi Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study
    D Otranto
    Dipartimento di Sanità Pubblica e Zootecnia, Universita degli Studi di Bari, Valenzano, BA, Italy
    Vet Parasitol 172:323-32. 2010
    ..The results demonstrate that ImPer preventive treatment against arthropods protects autochthonous and naïve beagle dogs against CVBD-causing pathogens...
  54. pmc Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence
    Ernesto J Muñoz-Elías
    Laboratory of Infection Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Nat Med 11:638-44. 2005
    ..tuberculosis on fatty acids and in macrophages. The absence of ICL orthologs in mammals should facilitate the development of glyoxylate cycle inhibitors as new drugs for the treatment of tuberculosis...
  55. ncbi Risk posed to honeybees (Apis mellifera L, Hymenoptera) by an imidacloprid seed dressing of sunflowers
    R Schmuck
    Bayer AG, Agricultural Centre, D 51368 Leverkusen, Germany
    Pest Manag Sci 57:225-38. 2001
    ..This conclusion is confirmed by observations made in more than 10 field studies and several tunnel tests...
  56. ncbi Structural model and functional characterization of the Bemisia tabaci CYP6CM1vQ, a cytochrome P450 associated with high levels of imidacloprid resistance
    Iris Karunker
    Department of Entomology, Faculty of Agriculture, The Hebrew University of Jerusalem, Rehovot, Israel
    Insect Biochem Mol Biol 39:697-706. 2009
    ..2 pmol/min/pmol P450, K(m) = 36 microM). The data identify CYP6CM1vQ as a principle target for inhibitor design, aimed at inactivating insecticide-metabolizing P450s in natural insect pest populations...
  57. ncbi Desensitizing and non-desensitizing subtypes of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in cockroach neurons
    Vincent L Salgado
    Bayer CropScience AG, Global Biology Insecticides, Alfred Nobel Strasse 50, D 40789 Monheim am Rhein, Germany
    J Insect Physiol 50:867-79. 2004
    ..Spinosyn A weakly antagonizes nAChD receptors -23% at 10 microM. The roles of the two nAChR subtypes in insecticide poisoning are discussed...
  58. ncbi Learning performances of honeybees (Apis mellifera L) are differentially affected by imidacloprid according to the season
    Axel Decourtye
    Laboratoire de Neurobiologie Comparée des Invertébrés, INRA, BP 23, La Guyonnerie, F 91440 Bures sur Yvette, France
    Pest Manag Sci 59:269-78. 2003
    ..The LOEC of imidacloprid was lower in summer bees (12 microg kg(-1)) than in winter bees (48 microg kg(-1)), which points to a greater sensitivity of honeybees behaviour in summer bees, compared to winter bees...
  59. ncbi Quantification of imidacloprid uptake in maize crops
    J M Bonmatin
    Centre de Biophysique Moleculaire, CNRS Centre National de la Recherche Scientifique and Université d Orléans, France
    J Agric Food Chem 53:5336-41. 2005
    ..PEC/PNEC risk ratios were determined and ranged between 500 and 600 for honeybees foraging on maize treated with imidacloprid by seed dressing. Such a high risk factor can be related to one of the main causes of honeybee colony losses...
  60. ncbi Sublethal effects of four insecticides on the reproduction and wing formation of brown planthopper, Nilaparvata lugens
    Haibo Bao
    Key Laboratory of Monitoring and Management of Plant Disease and Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095, China
    Pest Manag Sci 65:170-4. 2009
    ..Here, the effects of sublethal doses of these four insecticides on the reproduction and wing formation in BPH were examined...
  61. ncbi Dynamics of resistance to the neonicotinoids acetamiprid and thiamethoxam in Bemisia tabaci (Homoptera: Aleyrodidae)
    A Rami Horowitz
    Agricultural Research Organization, Department of Entomology, Gilat Research Center, M P Negev, 85280, Israel
    J Econ Entomol 97:2051-6. 2004
    ....
  62. pmc Gene expression profiling in the thiamethoxam resistant and susceptible B-biotype sweetpotato whitefly, Bemisia tabaci
    Wen Xie
    Department of Plant Protection, Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing, 100081, China
    J Insect Sci 12:46. 2012
    ..The distributed profiles show that it was highly expressed during the egg stage, and was most abundant in the abdomen of adult females...
  63. ncbi p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    Autophagy 5:339-50. 2009
    ..These results suggest that p53 plays roles in signaling both autophagy and apoptosis. Autophagy, at least partially, contributes to neurodegeneration induced by mitochondria dysfunction...
  64. ncbi Delayed toxicity as a critical factor in the efficacy of aqueous baits for controlling Argentine ants (Hymenoptera: Formicidae)
    Michael K Rust
    Department of Entomology, University of California, Riverside, Riverside, CA 92521 0314, USA
    J Econ Entomol 97:1017-24. 2004
    ..The utility of aqueous sucrose baits and toxicants soluble in such systems and the negative impact of fast-acting toxicants on trail following, recruitment, trophallaxis, and control of Argentine ants are discussed...
  65. ncbi Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway
    K Gopinath
    Department of Biochemistry, Cell Biology Laboratory, University of Madras, Guindy Campus, Chennai 600 025, Tamil Nadu, India
    Neuroscience 227:134-43. 2012
    ....
  66. ncbi Discriminative behavioral assessment unveils remarkable reactive astrocytosis and early molecular correlates in basal ganglia of 3-nitropropionic acid subchronic treated rats
    Giovanni Cirillo
    Dipartimento di Medicina Pubblica Clinica e Preventiva, Seconda Universita di Napoli, Napoli, Italy
    Neurochem Int 56:152-60. 2010
    ..Therefore this model unveil the key role played by the different components of the tripartite synapse in the pathogenesis of the HD, a putative non-cell-autonomous disease...
  67. ncbi Probucol modulates oxidative stress and excitotoxicity in Huntington's disease models in vitro
    Dirleise Colle
    Departamento de Bioquimica, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Brain Res Bull 87:397-405. 2012
    ..The toxic action of QA plus 3-NP seems to be involved with Ca2+ metabolism and ROS formation, and can be prevented or attenuated by antioxidant/scavenger compounds and NMDAr antagonists...
  68. ncbi Sublethal effects of imidacloprid on Bemisia tabaci (Hemiptera: Aleyrodidae) under laboratory conditions
    Yuxian He
    State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, People s Republic of China
    J Econ Entomol 104:833-8. 2011
    ..tabaci, which probably disrupts B. tabaci population dynamics, slows population increase, and reduces infestation levels. Therefore, it is necessary to consider potential impact from imidacloprid for integrated management of the pest...
  69. ncbi Acute and chronic toxicity of imidacloprid to the aquatic invertebrates Chironomus tentans and Hyalella azteca under constant- and pulse-exposure conditions
    Sarah J Stoughton
    Toxicology Centre, University of Saskatchewan, 44 Campus Drive, S7N 5B3, Saskatoon, SK, Canada
    Arch Environ Contam Toxicol 54:662-73. 2008
    ....
  70. pmc Assessing the essentiality of Leishmania donovani nitroreductase and its role in nitro drug activation
    Susan Wyllie
    Division of Biological Chemistry and Drug Discovery, Wellcome Trust Biocentre, College of Life Sciences, University of Dundee, Dundee, Scotland, United Kingdom
    Antimicrob Agents Chemother 57:901-6. 2013
    ..Modulation of nitroreductase levels in Trypanosoma brucei directly affected sensitivity to nitro compounds, with reduced concentrations of the enzyme leading to moderate nitro drug resistance...
  71. ncbi The influence of nicotinic receptor subunit composition upon agonist, alpha-bungarotoxin and insecticide (imidacloprid) binding affinity
    S J Lansdell
    Department of Pharmacology, University College London, UK
    Neuropharmacology 39:671-9. 2000
    ..Our results demonstrate that both alpha and non-alpha subunits exert a profound influence upon the affinity of nicotinic ligands for recombinant nAChRs...
  72. ncbi Unique and common metabolites of thiamethoxam, clothianidin, and dinotefuran in mice
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 19:1549-56. 2006
    ..The diversity of biodegradable sites and multiple pathways insures against parent compound accumulation but provides intermediates reported to be active as nicotinic agonists and inducible nitric oxide synthase inhibitors...
  73. ncbi Imidacloprid-induced facilitation of the proboscis extension reflex habituation in the honeybee
    M Lambin
    Laboratoire Neurobiologie de l Insecte, EA 3037, Université P Sabatier, Narbonne, Toulouse, France
    Arch Insect Biochem Physiol 48:129-34. 2001
    ..This result fits our hypothesis that a slight activation of the cholinergic system with a low dose of imidacloprid can facilitate a simple form of learning in the honeybee...
  74. ncbi Leaching behavior of imidacloprid formulations in soil
    S Gupta
    Division of Agricultural Chemicals, Indian Agricultural Research Institute, New Delhi
    Bull Environ Contam Toxicol 68:502-8. 2002
  75. ncbi Naturally-occurring nitro compounds
    Ronald Parry
    Department of Chemistry, Rice University, Houston, Texas, USA
    Nat Prod Rep 28:152-67. 2011
    Naturally-occurring nitro compounds display great structural diversity, and a wide range of biological activities...
  76. ncbi Trypanocidal activity of nitroaromatic prodrugs: current treatments and future perspectives
    Shane R Wilkinson
    Queen Mary Pre Clinical Drug Discovery Group, School of Biological and Chemical Sciences, Queen Mary University of London, UK
    Curr Top Med Chem 11:2072-84. 2011
    ..This approach has led to the identification of two new classes of anti-trypanosomal agents, nitrobenzylphosphoramide mustards and aziridinyl nitrobenzamides, and promises to yield new, safer, more effective drugs...
  77. ncbi Soil-applied imidacloprid is translocated to nectar and kills nectar-feeding Anagyrus pseudococci (Girault) (Hymenoptera: Encyrtidae)
    Vera A Krischik
    Department of Entomology, University of Minnesota, St Paul, MN 551081, USA
    Environ Entomol 36:1238-45. 2007
    ..2007)...
  78. ncbi European monitoring of resistance to insecticides in Myzus persicae and Aphis gossypii (Hemiptera: Aphididae) with special reference to imidacloprid
    R Nauen
    Bayer CropScience AG, Global Biology Insecticides, Alfred Nobel Str 50, D 40789 Monheim, Germany
    Bull Entomol Res 93:47-54. 2003
    ..The diagnostic concentration of methamidophos did not reveal any resistance in M. persicae, but did so in four strains of A. gossypii...
  79. ncbi Hazards of imidacloprid seed coating to Bombus terrestris (Hymenoptera: Apidae) when applied to sunflower
    J N Tasei
    , INRA, Lusignan, France
    J Econ Entomol 94:623-7. 2001
    ..terestris and its colony development...
  80. ncbi Calcium-dependent cleavage of endogenous wild-type huntingtin in primary cortical neurons
    Donato Goffredo
    Department of Pharmacological Sciences and Center of Excellence on Neurodegenerative Diseases, University of Milan, Milano, Italy
    J Biol Chem 277:39594-8. 2002
    ..This cleavage could be prevented by calcium chelators and calpain inhibitors. Degradation of wild-type huntingtin by calcium-dependent proteases thus occurs in HD neurons, leading to loss of wild-type huntingtin neuroprotective activity...
  81. ncbi Quinone formation as a chemoprevention strategy for hybrid drugs: balancing cytotoxicity and cytoprotection
    Tareisha Dunlap
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA
    Chem Res Toxicol 20:1903-12. 2007
    ..These results indicate a strategy for studying the quinone biological activity and reinforce the therapeutic attributes of NO-ASA through structural elements other than NO and ASA...
  82. ncbi Toxicity of three pesticides individually and in mixture to larval grass shrimp (Palaemonetes pugio)
    Peter Key
    NOAA, National Ocean Service, Center for Coastal Environmental Health and Biomolecular Research, 219 Fort Johnson Road, Charleston, SC 29412, USA
    Ecotoxicol Environ Saf 68:272-7. 2007
    ..Similarly, a fipronil/imidacloprid mixture did not show greater than additive toxicity. However, when atrazine was added to the fipronil/imidacloprid mix, greater than additive toxicity occurred...
  83. ncbi Chemistry and biology of thiamethoxam: a second generation neonicotinoid
    P Maienfisch
    Syngenta Crop Protection, Research and Technology, WRO 1060 1 14, CH 4002 Basel, Switzerland
    Pest Manag Sci 57:906-13. 2001
    ....
  84. pmc Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats
    Michael W Dryden
    Dept of Diagnostic Medicine Pathobiology, Kansas State University, Manhattan, KS 66506, USA
    Parasit Vectors 4:174. 2011
    ..The difference in the studies was that in study #1 efficacy evaluations were conducted at 24 and 48 hours post-treatment or post-infestation, and in study #2 evaluations were conducted at 12 and 24 hours...
  85. ncbi Functional cytochrome oxidase histochemistry in the honeybee brain
    C Armengaud
    Laboratoire de Neurobiologie de l Insecte, Universite de Toulouse III, 118 route de Narbonne, 31062, Toulouse, France
    Brain Res 859:390-3. 2000
    ..Treatment with a lower concentration (10(-8) M) resulted in reduced staining in Cal and central body (CB). We conclude that CO histochemistry can be used to identify the target structures of cholinergic ligands in the honeybee brain...
  86. ncbi Imidacloprid induces neurobehavioral deficits and increases expression of glial fibrillary acidic protein in the motor cortex and hippocampus in offspring rats following in utero exposure
    Mohamed B Abou-Donia
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Toxicol Environ Health A 71:119-30. 2008
    ..These changes may have long-term adverse health effects in the offspring...
  87. ncbi A nicotinic acetylcholine receptor agonist affects honey bee sucrose responsiveness and decreases waggle dancing
    Daren M Eiri
    Division of Biological Sciences, Section of Ecology, Behavior, and Evolution, University of California, San Diego, Mail Code 0116, 9500 Gilman Drive, La Jolla, CA 92093 0166, USA
    J Exp Biol 215:2022-9. 2012
    ..Waggle dancing can significantly increase colony food intake, and thus a sublethal dose (0.21 ng bee(-1), 24 p.p.b.) of this commonly used pesticide may impair colony fitness...
  88. ncbi Heteromeric co-assembly of two insect nicotinic acetylcholine receptor alpha subunits: influence on sensitivity to neonicotinoid insecticides
    Zewen Liu
    Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing, China
    J Neurochem 108:498-506. 2009
    ..These findings may be of importance in assessing the likely impact of the target-site mutations such as Y151S upon neonicotinoid insecticide resistance in insect field populations...
  89. ncbi Measuring and modelling mixture toxicity of imidacloprid and thiacloprid on Caenorhabditis elegans and Eisenia fetida
    Jose L Gomez-Eyles
    Department of Soil Science, School of Human and Environmental Sciences, University of Reading, Reading, Berkshire, UK
    Ecotoxicol Environ Saf 72:71-9. 2009
    ..For improving ecological risk assessment of simple mixtures, this implies that the concentration addition model may need to be used in a probabilistic context, rather than in its traditional deterministic manner...
  90. ncbi Mixture effects of the nonylphenyl polyethoxylate, R-11 and the insecticide, imidacloprid on population growth rate and other parameters of the crustacean, Ceriodaphnia dubia
    Xue Dong Chen
    Ecotoxicology Program, Department of Entomology, Washington State University, Puyallup Research and Extension Center, Puyallup, WA 98371, USA
    Ecotoxicol Environ Saf 73:132-7. 2010
    ..The results of this study indicate that when combined, R-11 and imidacloprid act in a more than additive manner. Therefore, it is important that their potential effects on aquatic organisms be evaluated together...
  91. ncbi Evaluation of topical application of 10% imidacloprid-1% moxidectin to prevent Bartonella henselae transmission from cat fleas
    Christina A Bradbury
    Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA
    J Am Vet Med Assoc 236:869-73. 2010
    ..To determine whether monthly topical administration of a combination of 10% imidacloprid and 1% moxidectin would lessen flea (Ctenocephalides felis) transmission of Bartonella henselae among cats...
  92. ncbi Behavioral and biochemical effects of neonicotinoid thiamethoxam on the cholinergic system in rats
    K J A Rodrigues
    Departamento de Fisiologia, Centro de Ciencias Biologicas, Universidade Federal do Para, Belem PA, Brazil
    Ecotoxicol Environ Saf 73:101-7. 2010
    ..Our hypothesis is that thiamethoxam (or its metabolites) could be acting on the central rats nAChRs. This would produce an alteration on the cholinergic transmission, modulating the anxiety behavior, acetylcholinesterase levels and HACU...
  93. pmc Efficacy of an imidacloprid/flumethrin collar against fleas and ticks on cats
    Dorothee Stanneck
    Bayer HealthCare AG, Animal Health Division, D 51368 Leverkusen, Germany
    Parasit Vectors 5:82. 2012
    ..The number of studies was so large that only a general overview can be presented in this abstract...
  94. ncbi Evaluation of the efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of generalized demodicosis in dogs: results of a European field study
    J Heine
    Bayer HealthCare AG, Animal Health Division, R and D Parasiticides, Leverkusen, Germany
    Parasitol Res 97:S89-96. 2005
    ..Statistical evaluation confirmed that the efficacy of the test product in the treatment of generalized canine demodicosis was not inferior to that of milbemycin oxime...
  95. ncbi Antifeedant and sublethal effects of imidacloprid on Asian citrus psyllid, Diaphorina citri
    Dhana Raj Boina
    Entomology and Nematology Department, Citrus Research and Education Center, University of Florida, Lake Alfred, FL 33850, USA
    Pest Manag Sci 65:870-7. 2009
    ..The objective of this laboratory study was to determine the effects of sublethal concentrations of imidacloprid on ACP life stages...
  96. ncbi Hazards of insecticides to the bumble bees Bombus impatiens (Hymenoptera: Apidae) foraging on flowering white clover in turf
    Jerome A Gels
    Department of Entomology, University of Kentucky, Lexington 40546 0091, USA
    J Econ Entomol 95:722-8. 2002
    ..Foraging workers did not avoid insecticide-treated areas. Means by which turf managers can reduce hazards of insecticide applications to pollinators are discussed...
  97. ncbi Chloropyridinyl neonicotinoid insecticides: diverse molecular substituents contribute to facile metabolism in mice
    Kevin A Ford
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, 94720 3112, USA
    Chem Res Toxicol 19:944-51. 2006
  98. ncbi Management of cottonwood leaf beetle (Coleoptera: Chrysomelidae) with a novel transplant soak and biorational insecticides to conserve coccinellid beetles
    Emily G Tenczar
    Department of Entomology, University of Minnesota, 219 Hodson Hall, 1980 Folwell Avenue, St Paul, MN 55108, USA
    J Econ Entomol 99:102-8. 2006
    ..scripta for 10 mo without any symptoms of phytotoxicity. The novel stick soak method did not kill two species of coccinellids when foraging on leaves...
  99. ncbi Effect of seven new orchard pesticides on Galendromus occidentalis in laboratory studies
    Noubar J Bostanian
    Horticulture Research and Development Centre, Agriculture and Agri Food Canada, St Jean sur Richelieu, Quebec, Canada
    Pest Manag Sci 65:635-9. 2009
    ..This study evaluates the possible toxic attributes of acetamiprid, imidacloprid, thiacloprid, thiamethoxam, spirodiclofen, spinosad and methoxyfenoxide currently used in western Canadian orchards...
  100. ncbi Native subunit composition of two insect nicotinic receptor subtypes with differing affinities for the insecticide imidacloprid
    Jian Li
    Key Laboratory of Monitoring and Management of Plant Diseases and Insects, Ministry of Agriculture, College of Plant Protection, Nanjing Agricultural University, Tongwei Road 6, Nanjing, China
    Insect Biochem Mol Biol 40:17-22. 2010
    ..lugens...
  101. ncbi Low expression of nicotinic acetylcholine receptor subunit Mdα2 in neonicotinoid-resistant strains of Musca domestica L
    Mette D K Markussen
    Department of Integrated Pest Management, Aarhus University, Denmark
    Pest Manag Sci 66:1257-62. 2010
    ..The genomic sequence covering exon III-VII of Mdα2 was analysed for mutations...

Research Grants55

  1. Therapeutic Corneal Cross-linking Using Aliphatic Beta-Nitroalcohols
    David C Paik; Fiscal Year: 2013
    ..The results from this aim will establish the toxicity level of nitro compounds to corneal cells...
  2. A Novel Treatment for Keratoconus and Keratectasias using Nitro Technology
    David C Paik; Fiscal Year: 2010
    ..The cells will then be exposed to nitro compounds found to be efficacious for cross-linking...
  3. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  4. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  5. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  6. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  7. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  8. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  9. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003
    ..During the period which corresponds to this proposal, we plan to apply our new methodology to the synthesis of deacetylravidomycin and kidamycin, representatives of the remaining two major classes. ..
  10. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  11. F-18 Synthesizer
    Anna Liisa Brownell; Fiscal Year: 2007
    ..The synthesizer must balance a number of factors in the design to fulfill requirements for performance, accessibility and fitness to the research environment. [unreadable] [unreadable] [unreadable]..
  12. BIOSYNTHESIS OF SOME MICROBIAL METABOLITES
    Ronald Parry; Fiscal Year: 2007
    ..Future investigations of sparsomycin will focus on cloning the sparsomycin resistance gene from S. sparsogenes to understand the mechanism of self-resistance in this organism and to gain access to the biosynthetic genes. ..
  13. Bioenergetics in Animal Models of Huntington's Disease
    M Beal; Fiscal Year: 2007
    ..We will, therefore, examine whether a combination of creatine or coenzyme Q with either a HDAC inhibitor or a phosphodiesterase IV inhibitor can exert additive neuroprotective effects. [unreadable] [unreadable]..
  14. MASS SPECTROMETRIC IDENTIFICATION OF NEW LIPID MEDIATORS
    Michael Balazy; Fiscal Year: 2005
    ....
  15. Antioxidant Approaches to Alzheimer's Disease Therapy
    M Beal; Fiscal Year: 2007
    ..If we can demonstrate significant effects of CoQ10 and L-NIL, this could lead to rapid development of new therapies for slowing the progression of AD. [unreadable] [unreadable]..
  16. Combination Drug Therapy in Huntington's Disease
    ROBERT FERRANTE; Fiscal Year: 2008
    ..abstract_text> ..
  17. Reconstruction of nigrostriatal pathway by photopolymerized neurotrophin...
    Kimberly Bjugstad; Fiscal Year: 2008
    ..While we are using an animal model of PD to test this hypothesis, if successful, it could have implications for other neurodegenerative disorders, including Huntington's Disease or stroke. [unreadable] [unreadable] [unreadable]..
  18. Olfaction as a Biomarker for Parkinson's Disease
    Anna Liisa Brownell; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Interactions for Pesticides, mitochondria and genetics in Parkinson's disease.
    M Flint Beal; Fiscal Year: 2010
    ..The study will enrich and refine our understanding of pesticide-induced cell damage pathways observed in sporadic and familial PD and identify new target(s) for intervention in PD pathogenesis. ..
  20. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  21. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  22. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  23. Noninvasive Monitoring of In Situ Oxygenation and Cell Therapy in Infarct Heart
    Periannan Kuppusamy; Fiscal Year: 2010
    ..The availability of these innovative probes and technologies will enhance our ability to monitor cell therapy and should open new avenues in the treatment of heart disease in humans. ..
  24. OXIDATIVE INJURY IN PARKINSONS DISEASE
    ROBERT FERRANTE; Fiscal Year: 2002
    ..These studies will have direct relevance to understanding the pathogenesis of PD and to developing new therapies. ..
  25. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  26. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  27. Development of New Therapies for Huntington's Disease
    M Beal; Fiscal Year: 2008
    ..We believe that these studies will provide critical pre-clinical data to determine the agents, which have the most promise for use as neuroprotective agents in clinical drug trials in HD patients. ..
  28. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  29. Development of NET-Selective Piperidine-Based PET Ligand
    Anna Liisa Brownell; Fiscal Year: 2006
    ..4. Promising PET imaging agents will be studied in cell toxicity and animal models during the second year. ..
  30. Chemical Basis for Potassium Channel Modulation
    PAMELA ENGLAND; Fiscal Year: 2006
    ..To determine the site(s) in HERG that interact with other proteins, photoreactive amino acids capable of forming protein cross-links will be site-specifically incorporated into the HERG. ..
  31. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2003
    ..Awards will be made without regard to gender, race or ethnicity or disability. ..
  32. Micro Lock-In Amplifer for Cortisol and Catecholamines
    Antonio Garcia; Fiscal Year: 2003
    ..Applications to wellness, therapeutic drug monitoring, and bio or chemical exposure are envisioned using the general approach of microlock-in amplifier detection technology. ..
  33. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  34. FLOW SHEAR INDUCED NF-KB MEDIATED REGULATION
    Sumathy Mohan; Fiscal Year: 2003
    ..Understanding of NF- kappaB signaling mechanisms in VCAM-1 regulation can also be applied to other inflammatory conditions. ..
  35. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  36. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2002
    ..Awards will be made without regard to gender, race or ethnicity. ..
  37. BIOSYNTHESIS AND METABOLISM OF CYCLOPENTANOIDS
    Ronald Parry; Fiscal Year: 2001
    ..The potential use of the CmaA gene for construction of hybrid peptide antibiotics containing L-alloisoleucine or coronamic acid will also be explored, using surfactin biosynthesis in B. subtilis as a model system. ..
  38. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  39. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  40. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  41. Dopamine Toxicity in Models of Huntington's Disease
    William Maragos; Fiscal Year: 2004
    ..The results of these studies will demonstrate the critical role that metabolism of dopamine plays in striatal neuron death in Huntington's disease and offer a potentially novel therapeutic approach for the treatment of this disorder. ..
  42. Novel Approaches for in vivo of mGluRs
    Anna Liisa Brownell; Fiscal Year: 2006
    ..abstract_text> ..
  43. CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING
    Periannan Kuppusamy; Fiscal Year: 2005
    ..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
  44. SYNTHESIS AND EVALUATION OF NOVEL PHOSPHORAMIDATES
    RICHARD BORCH; Fiscal Year: 2005
    ..The ultimate goal is to exploit the unique properties of phosphoramidate chemistry to develop new drugs that exhibit clinical efficacy against resistant or poorly responsive solid tumors. ..
  45. METHAMPHETAMINE AND HIV PROTEIN-INDUCED NEUROTOXICITY
    William Maragos; Fiscal Year: 2005
    ..To accomplish these goals, we will assess the effects of intrastriatal injections of virotoxins in animals treated with methamphetamine and in vitro in human cortical neurons where cell types can be manipulated. ..
  46. MICROPET FOR ANIMAL STUDIES
    Anna Liisa Brownell; Fiscal Year: 2001
    ..Our previous experience in developing and operating PET systems will be of great benefit in the expansion of the facility. ..
  47. 2004 Biophysical Discussion: Membrane Microdomains
    Kenneth Jacobson; Fiscal Year: 2004
    ..The format of the Biophysical Discussions is unique in its stress on discussion and prior preparation by the participants. ..
  48. Fostriecin and Related Protein Phosphatase Inhibitors
    Dale Boger; Fiscal Year: 2005
    ....
  49. Student Travel to the Environmental Mutagen Society
    Michael Plewa; Fiscal Year: 2004
    ..Awards will be made without regard to gender, race, ethnicity or disability. ..
  50. EPR IMAGING OF TUMOR HETEROGENEITY AND OXYGENATION
    Periannan Kuppusamy; Fiscal Year: 2003
    ..Information obtained from these studies should enable the development and optimization of therapeutic modalities for cancer treatment. ..
  51. Novel Methods for in Vivo Imaging of Tissue Oxygenation
    Periannan Kuppusamy; Fiscal Year: 2008
    ..The technology should offer exciting new opportunities in the field of biomedical imaging of free radicals and oxygen. ..
  52. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  53. In Vivo EPR Imaging of Redox Status and Thiols in Tumor
    Periannan Kuppusamy; Fiscal Year: 2007
    ..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
  54. Apoptotic and Necrotic Death of OHCs in NIHL
    Bo Hua Hu; Fiscal Year: 2006
    ..The knowledge of the biological mechanisms responsible for modulation of the cell death pathways will provide the basis for eventually developing a rational protective strategy. ..