nitrites

Summary

Summary: Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    K M Miranda
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, Maryland 20892, USA
    Nitric Oxide 5:62-71. 2001
  2. ncbi The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nat Rev Drug Discov 7:156-67. 2008
  3. pmc A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria
    Sebastian Lücker
    Department of Microbial Ecology, Ecology Centre, University of Vienna, 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 107:13479-84. 2010
  4. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
  5. ncbi Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    Sruti Shiva
    Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circ Res 100:654-61. 2007
  6. pmc Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    Mark R Duranski
    Department of Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    J Clin Invest 115:1232-40. 2005
  7. ncbi Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 2:486-93. 2006
  8. ncbi Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
    Petra Kleinbongard
    Division of Cardiology, Pulmonary Diseases and Angiology, Department of Medicine, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 40:295-302. 2006
  9. ncbi Anaerobic ammonium oxidation by anammox bacteria in the Black Sea
    Marcel M M Kuypers
    Max Planck Institute for Marine Microbiology, Department of Biogeochemistry, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 422:608-11. 2003
  10. pmc Nitrate and nitrite in biology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nat Chem Biol 5:865-9. 2009

Research Grants

  1. Toxicokinetics and Toxicodynamics of Nitrite Inhalants
    Ho Leung Fung; Fiscal Year: 2005
  2. Role of Insulin Receptors in the Kidney
    CAROLYN MARY ECELBARGER; Fiscal Year: 2013
  3. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
  4. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
  5. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2013
  6. Nitrites as Antidotes for Hydrogen Sulfide Poisoning
    James Peterson; Fiscal Year: 2013
  7. Acute Cyanide Toxicity, Complex IV, NO & Nitrite
    James Peterson; Fiscal Year: 2010
  8. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
  9. STEROIDS /VASCULAR REACTIVITY /NITRIC OXIDE PRODUCTION
    Maureen Keller Wood; Fiscal Year: 2002
  10. BEHAVIORAL PHARMACOLOGY OF ABUSED SOLVENTS
    Robert Balster; Fiscal Year: 1992

Detail Information

Publications293 found, 100 shown here

  1. ncbi A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    K M Miranda
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, Maryland 20892, USA
    Nitric Oxide 5:62-71. 2001
    ..This report introduces a new, convenient assay for the stable oxidation products of nitrogen oxide chemistry in biological samples...
  2. ncbi The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nat Rev Drug Discov 7:156-67. 2008
    ....
  3. pmc A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria
    Sebastian Lücker
    Department of Microbial Ecology, Ecology Centre, University of Vienna, 1090 Vienna, Austria
    Proc Natl Acad Sci U S A 107:13479-84. 2010
    ....
  4. ncbi Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
    Kenyatta Cosby
    Cardiovascular Branch, National Heart, Lung and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10, Room 7B15 Bethesda, Maryland 20892, USA
    Nat Med 9:1498-505. 2003
    ..These results suggest that nitrite represents a major bioavailable pool of NO, and describe a new physiological function for hemoglobin as a nitrite reductase, potentially contributing to hypoxic vasodilation...
  5. ncbi Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration
    Sruti Shiva
    Vascular Medicine Branch, Clinical Center National Institutes of Health, Bethesda, MD 20892 1662, USA
    Circ Res 100:654-61. 2007
    ....
  6. pmc Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
    Mark R Duranski
    Department of Physiology, Louisiana State University Health Sciences Center, Shreveport, 71130, USA
    J Clin Invest 115:1232-40. 2005
    ..These studies reveal an unexpected and novel therapy for diseases such as myocardial infarction, organ preservation and transplantation, and shock states...
  7. ncbi Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis
    Sruti Shiva
    Vascular Medicine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Chem Biol 2:486-93. 2006
    ....
  8. ncbi Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
    Petra Kleinbongard
    Division of Cardiology, Pulmonary Diseases and Angiology, Department of Medicine, Heinrich Heine University, D 40225 Dusseldorf, Germany
    Free Radic Biol Med 40:295-302. 2006
    ..Future studies are necessary to identify the prognostic relevance of plasma nitrite determination in patients suffering from cardiovascular disease...
  9. ncbi Anaerobic ammonium oxidation by anammox bacteria in the Black Sea
    Marcel M M Kuypers
    Max Planck Institute for Marine Microbiology, Department of Biogeochemistry, Celsiusstrasse 1, 28359 Bremen, Germany
    Nature 422:608-11. 2003
    ..The widespread occurrence of ammonium consumption in suboxic marine settings indicates that anammox might be important in the oceanic nitrogen cycle...
  10. pmc Nitrate and nitrite in biology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nat Chem Biol 5:865-9. 2009
    ..The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm...
  11. pmc Combined molecular and conventional analyses of nitrifying bacterium diversity in activated sludge: Nitrosococcus mobilis and Nitrospira-like bacteria as dominant populations
    S Juretschko
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, D 80290 Munich, Germany
    Appl Environ Microbiol 64:3042-51. 1998
    ..FISH of the activated sludge with this probe demonstrated that Nitrospira-like bacteria were present in significant numbers (9% of the total bacterial counts) and frequently occurred in coaggregated microcolonies with N. mobilis...
  12. pmc Revising the nitrogen cycle in the Peruvian oxygen minimum zone
    Phyllis Lam
    Max Planck Institute for Marine Microbiology, D 28359 Bremen, Germany
    Proc Natl Acad Sci U S A 106:4752-7. 2009
    ....
  13. pmc Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation
    Jack H Crawford
    Department of Pathology, Center for Free Radical Biology, University of Alabama at Birmingham, 35294, USA
    Blood 107:566-74. 2006
    ..These data support a function for RBC hemoglobin as an allosterically and redox-regulated nitrite reductase whose "enzyme activity" couples hypoxia to increased NO-dependent blood flow...
  14. ncbi Cultivation of a novel cold-adapted nitrite oxidizing betaproteobacterium from the Siberian Arctic
    Mashal Alawi
    Department of Biology, Biocenter Klein Flottbek, University of Hamburg, Hamburg, Germany
    ISME J 1:256-64. 2007
    ..We propose provisional classification of the novel nitrite oxidizing bacterium as 'Candidatus Nitrotoga arctica'...
  15. pmc Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1beta, TNF-alpha and IL-6 in an in-vitro model of brain inflammation
    Henrik Wilms
    Department of Neurology, University of Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany
    J Neuroinflammation 7:30. 2010
    ..The purpose of this study was to use an established in vitro model of brain inflammation to determine if DMF modulates the release of neurotoxic molecules from microglia and astrocytes, thus inhibiting glial inflammation...
  16. ncbi Regulation of nitric oxide (NO) production by plant nitrate reductase in vivo and in vitro
    Peter Rockel
    Forschungszentrum Julich GmbH, Institut für Biologie des Stoffaustauschs, 52425 Julich, Germany
    J Exp Bot 53:103-10. 2002
    ..It is concluded that in non-elicited leaves NO is produced in variable quantities by NR depending on the total NR activity, the NR activation state and the cytosolic nitrite and nitrate concentration...
  17. pmc Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
    Andrew J Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Hypertension 51:784-90. 2008
    ..These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a "natural" low cost approach for the treatment of cardiovascular disease...
  18. ncbi A new obligately chemolithoautotrophic, nitrite-oxidizing bacterium, Nitrospira moscoviensis sp. nov. and its phylogenetic relationship
    S Ehrich
    , , Germany
    Arch Microbiol 164:16-23. 1995
    ..The isolated bacterium is designated as a new species of the genus Nitrospira.(ABSTRACT TRUNCATED AT 250 WORDS)..
  19. ncbi Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues
    Nathan S Bryan
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Nat Chem Biol 1:290-7. 2005
    ..Thus, nitrite homeostasis may be of great importance to NO biology...
  20. ncbi Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin
    Rozalina Grubina
    Vascular Medicine Branch, NHLBI, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 282:12916-27. 2007
    ....
  21. pmc Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer
    Sruti Shiva
    Vascular Medicine Branch, National Heart Lung Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 204:2089-102. 2007
    ..These data suggest that nitrite dynamically modulates mitochondrial resilience to reperfusion injury and may represent an effector of the cell-survival program of ischemic preconditioning and the Mediterranean diet...
  22. pmc Nitrite as regulator of hypoxic signaling in mammalian physiology
    Ernst E van Faassen
    Department of Interface Physics, Debye Institute, Utrecht University, Princetonplein 1, 3508 TA Utrecht, The Netherlands
    Med Res Rev 29:683-741. 2009
    ..We here discuss the mechanisms and properties of these various pathways and the role played by the local concentration of free oxygen in the affected tissue...
  23. ncbi Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals
    Petra Kleinbongard
    Department of Medicine, Division of Cardiology, Pulmonary Diseases, Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 35:790-6. 2003
    ..These results provide evidence for a uniform constitutive vascular NOS-activity across mammalian species...
  24. pmc Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury
    Ulrike B Hendgen-Cotta
    Department of Medicine, Division of Cardiology, Pulmonology and Vascular Medicine, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany
    Proc Natl Acad Sci U S A 105:10256-61. 2008
    ..These data support an emerging paradigm that myoglobin and the heme globin family subserve a critical function as an intrinsic nitrite reductase that regulates responses to cellular hypoxia and reoxygenation [corrected]..
  25. ncbi Experimental demonstration of chaotic instability in biological nitrification
    David W Graham
    School of Civil Engineering and Geosciences, Newcastle University, Newcastle upon Tyne, UK
    ISME J 1:385-93. 2007
    ..We conclude that nitrification is prone to chaotic behavior because of a fragile AOB-NOB mutualism, which must be considered in all systems that depend on this critical reaction...
  26. ncbi Nitrite concentration influences the population structure of Nitrospira-like bacteria
    Frank Maixner
    , , Althanstrasse 14, A 1090 Vienna, Austria
    Environ Microbiol 8:1487-95. 2006
    ..Consistent with the observed localization patterns, a higher nitrite concentration selected for sublineage I but suppressed sublineage II Nitrospira...
  27. pmc In situ characterization of Nitrospira-like nitrite-oxidizing bacteria active in wastewater treatment plants
    H Daims
    , , 85350 Freising, Germany
    Appl Environ Microbiol 67:5273-84. 2001
    ..In contrast, no uptake by the Nitrospira-like bacteria of any of the carbon sources tested was observed under anoxic or anaerobic conditions...
  28. ncbi The emerging biology of the nitrite anion
    Mark T Gladwin
    Vascular Medicine Branch, National Heart, Lung, and Blood Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Chem Biol 1:308-14. 2005
    ..A recent two-day symposium at the US National Institutes of Health highlighted recent advances in the understanding of nitrite biochemistry, physiology and therapeutics...
  29. ncbi The membrane bioreactor: a novel tool to grow anammox bacteria as free cells
    Wouter R L van der Star
    Department of Biotechnology, Delft University of Technology, Julianalaan 67, 2628BC Delft, The Netherlands
    Biotechnol Bioeng 101:286-94. 2008
    ..The production of anammox bacteria in suspension with high purity and productivity makes the MBR a promising tool for the cultivation and study of anammox bacteria...
  30. ncbi Nitrite in nitric oxide biology: cause or consequence? A systems-based review
    Nathan S Bryan
    Institute of Molecular Medicine, University of Texas at Houston Health Sciences Center, 1825 Pressler, Houston, TX 77030, USA
    Free Radic Biol Med 41:691-701. 2006
    ....
  31. ncbi The influence of soil pH on the diversity, abundance and transcriptional activity of ammonia oxidizing archaea and bacteria
    Graeme W Nicol
    Institute of Biological and Environmental Science, University of Aberdeen, Cruickshank Building, Aberdeen, UK
    Environ Microbiol 10:2966-78. 2008
    ..They also suggest that both groups of ammonia oxidizers have distinct physiological characteristics and ecological niches, with consequences for nitrification in acid soils...
  32. pmc Nitrosatable drug exposure during early pregnancy and neural tube defects in offspring: National Birth Defects Prevention Study
    Jean D Brender
    School of Rural Public Health, Texas A and M Health Science Center, College Station, USA
    Am J Epidemiol 174:1286-95. 2011
    ..Prenatal exposure to nitrosatable drugs may increase the risk of neural tube defects, especially in conjunction with a mother's higher dietary intake of nitrites, but vitamin C might modulate this association.
  33. pmc Nitric oxide metabolites induced in Anopheles stephensi control malaria parasite infection
    Tina M L Peterson
    Department of Biochemistry, Virginia Tech, Blacksburg, VA 24061, USA
    Free Radic Biol Med 42:132-42. 2007
    ..Our data indicate that nitrates, but not nitrites, are elevated in the Plasmodium-infected midgut...
  34. ncbi Isolation and characterization of a moderately thermophilic nitrite-oxidizing bacterium from a geothermal spring
    Elena V Lebedeva
    Winogradsky Institute of Microbiology, Russian Academy of Sciences, Moscow, Russia
    FEMS Microbiol Ecol 75:195-204. 2011
    ..6-96.1% 16S rRNA gene sequence similarity). The findings confirmed that Nitrospira drive nitrite oxidation in moderate thermophilic habitats and also indicated an unexpected diversity of heat-adapted Nitrospira in geothermal hot springs...
  35. pmc Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control
    Zhi Huang
    Vascular Therapeutics Section, Cardiovascular Branch, National Heart, Lung and Blood Institute, and Laboratory of Chemical Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, Maryland 20892 1662, USA
    J Clin Invest 115:2099-107. 2005
    ..These data suggest that the oxygen sensor for hypoxic vasodilation is determined by Hb oxygen saturation and quaternary structure and that the nitrite reductase activity of Hb generates NO gas under allosteric and pH control...
  36. pmc Contrasting denitrifier communities relate to contrasting N2O emission patterns from acidic peat soils in arctic tundra
    Katharina Palmer
    Department of Ecological Microbiology, University of Bayreuth, Bayreuth, Germany
    ISME J 6:1058-77. 2012
    ..The collective data indicate that the contrasting N(2)O emission patterns of cryoturbated and unturbated peat soils are associated with contrasting denitrifier communities...
  37. pmc In situ analysis of nitrifying biofilms as determined by in situ hybridization and the use of microelectrodes
    S Okabe
    Department of Urban and Environmental Engineering, Faculty of Engineering, Hokkaido University, Sapporo 060 0813, Japan
    Appl Environ Microbiol 65:3182-91. 1999
    ....
  38. ncbi Ammonia-oxidizing archaea and nitrite-oxidizing nitrospiras in the biofilter of a shrimp recirculating aquaculture system
    Monisha N Brown
    Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, MI 48109, USA
    FEMS Microbiol Ecol 83:17-25. 2013
    ..moscoviensis-type NOB. Water quality and biofilm attachment media played a role in the competitiveness of AOA over AOB and Nitrospira marina-over N. moscoviensis-type NOB...
  39. ncbi The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash
    Mirco Govoni
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 17177 Stockholm, Sweden
    Nitric Oxide 19:333-7. 2008
    ..The removal of these bacteria with an antibacterial mouthwash will very likely attenuate the NO-dependent biological effects of dietary nitrate...
  40. ncbi Reductive dehalogenation mediated initiation of aerobic degradation of 2-chloro-4-nitrophenol (2C4NP) by Burkholderia sp. strain SJ98
    Janmejay Pandey
    Institute of Microbial Technology CSIR, Sector 39 A, Chandigarh, 160036, India
    Appl Microbiol Biotechnol 92:597-607. 2011
    ....
  41. ncbi NO generation from nitrite and its role in vascular control
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 25:915-22. 2005
    ..With this new knowledge, nitrate and nitrite should probably be viewed as storage pools for NO rather than inert waste products. Here we discuss novel aspects of nitrite-dependent NO generation in vivo and its role in vascular control...
  42. pmc Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice
    Nathan S Bryan
    The Brown Foundation Institute of Molecular Medicine, University of Texas Houston Health Sciences Center, Houston, TX 77030, USA
    Free Radic Biol Med 45:468-74. 2008
    ..Dietary nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a novel prevention/treatment modality for disease associated with NO insufficiency...
  43. pmc Nitrite regulates hypoxic vasodilation via myoglobin-dependent nitric oxide generation
    Matthias Totzeck
    Department of Medicine, Division of Cardiology, Pulmonology, and Vascular Medicine, University Hospital Duesseldorf, Germany
    Circulation 126:325-34. 2012
    ....
  44. pmc Short-term effect of the HMG-CoA reductase inhibitor rosuvastatin on erythrocyte nitric oxide synthase activity
    Barbara Ludolph
    Department of Medicine, Medical Clinic I, University Hospital RTWH Aachen, Germany
    Vasc Health Risk Manag 3:1069-73. 2007
    ..This NO dependent effect of rosuvastatin might have an important influence on microcirculation and may offer new perspectives for the therapeutic use of statins...
  45. ncbi Kinetic characterisation of an enriched Nitrospira culture with comparison to Nitrobacter
    Richard Blackburne
    Advanced Wastewater Management Centre, The University of Queensland, Brisbane 4072, Australia
    Water Res 41:3033-42. 2007
    ....
  46. ncbi Denitrification as the dominant nitrogen loss process in the Arabian Sea
    B B Ward
    Department of Geosciences, Princeton University, Princeton, New Jersey 08544, USA
    Nature 461:78-81. 2009
    ..The large contribution of denitrification to N(2) loss in the Arabian Sea indicates the global significance of denitrification to the oceanic nitrogen budget...
  47. pmc Correlation between anammox activity and microscale distribution of nitrite in a subtropical mangrove sediment
    Rikke Louise Meyer
    Advanced Wastewater Management Centre, The University of Queensland, St Lucia, QLD 4072, Australia
    Appl Environ Microbiol 71:6142-9. 2005
    ..This finding suggests that denitrification, though using NO2- as a substrate, also provides a substrate for the anammox process, which has been suggested in previous studies where microscale NO2- profiles were not measured...
  48. ncbi A new intra-aerobic metabolism in the nitrite-dependent anaerobic methane-oxidizing bacterium Candidatus 'Methylomirabilis oxyfera'
    Ming L Wu
    Department of Microbiology, Radboud University Nijmegen, Institute for Water and Wetland Research, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands
    Biochem Soc Trans 39:243-8. 2011
    ..The present mini-review summarizes the current knowledge about this process and the micro-organism responsible for it...
  49. pmc Reliability of serum iron, ferritin, nitrite, and association with risk of renal cancer in women
    M Aktar Ali
    Department of Environmental Medicine, NYU School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Cancer Detect Prev 27:116-21. 2003
    ..55, 95% CI, 0.15-2.01 for ferritin, and OR, 0.52, 95% CI, 0.17-1.60 for nitrite in women with above median level as compared to women with below median level). The possible role of ferritin and nitrite in renal cancer is discussed...
  50. ncbi Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO
    Vikas Kapil
    William Harvey Research Institute, Barts and London Medical School, Queen Mary University of London, London, UK
    Hypertension 56:274-81. 2010
    ....
  51. ncbi Toll-like receptor-mediated activation of B cells and macrophages by polysaccharide isolated from cell culture of Acanthopanax senticosus
    S B Han
    Biopotency Evaluation Laboratory, Korea Research Institute of Bioscience and Biotechnology KRIBB, 52 Oundong, Yusong, Taejon 305 333, South Korea
    Int Immunopharmacol 3:1301-12. 2003
    ..senticosus, activates B cells and macrophages by interacting with TLRs and leading to the subsequent activation of mitogen-activated protein kinases and NF-kappaB...
  52. ncbi Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues
    Tienush Rassaf
    Department of Medicine, Division of Cardiology, Pulmonary Diseases and Angiology, Heinrich Heine University, Duesseldorf, Germany
    Free Radic Biol Med 36:413-22. 2004
    ..In addition, we attempt to give a recommendation as to the most appropriate analytical technique and sample processing procedures for the reliable quantification of either species...
  53. ncbi Evaluating the effect of dissolved oxygen on ammonia-oxidizing bacterial communities in activated sludge
    Hee Deung Park
    Department of Civil and Environmental Engineering, 1415 Engineering Drive, University of Wisconsin, Madison, WI 53706, USA
    Water Res 38:3275-86. 2004
    ..Only the train operated with DO concentrations below 1mg/L favored the establishment of a population of AOB related to the N. europaea lineage...
  54. pmc Assimilation of nitrogen from nitrite and trinitrotoluene in Pseudomonas putida JLR11
    Antonio Caballero
    Consejo Superior de Investigaciones Cientificas, Estacion Experimental del Zaidin, Department of Biochemistry and Molecular and Cellular Biology of Plants, Granada, Spain
    J Bacteriol 187:396-9. 2005
    ..Three mutants that had insertions in ntrC, nasT, and cnmA, which encode regulatory proteins, failed to grow on nitrite but grew on TNT, although slower than the wild type...
  55. ncbi Nitrate and nitrite transport in bacteria
    J W Moir
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
    Cell Mol Life Sci 58:215-24. 2001
    ..A hypothesis for nitrate and nitrite transport is proposed based on the finding that there are two distinct types of NarK...
  56. pmc Identification of nitrite-oxidizing bacteria with monoclonal antibodies recognizing the nitrite oxidoreductase
    S Bartosch
    , , D 22609 Hamburg, Germany
    Appl Environ Microbiol 65:4126-33. 1999
    ..Permeated cells of pure cultures of members of the four genera were suitable for immunofluorescence labeling; these cells exhibited fluorescence signals that were consistent with the location of the NOS...
  57. ncbi NarK is a nitrite-extrusion system involved in anaerobic nitrate respiration by Escherichia coli
    J J Rowe
    Department of Biology, University of Dayton, Ohio 45469 2320
    Mol Microbiol 12:579-86. 1994
    ..This process prevents intracellular accumulation of toxic levels of nitrite and allows further detoxification in the periplasm through the action of nitrite reductase...
  58. pmc The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis
    K Ogawa
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    J Bacteriol 177:1409-13. 1995
    ..subtilis, which are required for nitrate/nitrite assimilation, is reported. The probable gene products include subunits of nitrate/nitrite reductases and an enzyme involved in the synthesis of siroheme, a cofactor for nitrite reductase...
  59. ncbi Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine
    S Carlsson
    Department of Surgery, Section of Urology, Karolinska Hospital, Stockholm, Sweden
    Nitric Oxide 5:580-6. 2001
    ..These results may help to explain the well-known beneficial effects of urinary acidification with, e.g., vitamin C in treatment and prevention of urinary tract infection...
  60. pmc Nitrification and nitrifying bacteria in the lower Seine River and estuary (France)
    Aurélie Cébron
    UMR Sisyphe 7619, Universite Pierre et Marie Curie Paris 6, 75005 Paris, France
    Appl Environ Microbiol 69:7091-100. 2003
    ..These results imply a significant immigration and/or selection of the ammonia-oxidizing bacterial population along the continuum of the Seine River from Paris to the estuary...
  61. ncbi Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats
    Chain Fa Su
    Department of Neurosurgery, Tzu Chi Hospital and Tzu Chi University, 701 Section 3 Chung Yang Road, Hualien 97004, Taiwan
    Clin Exp Pharmacol Physiol 34:339-46. 2007
    ..Inhibition of iNOS is effective in mitigating the endotoxaemic changes and lung pathology. Inhibitors of iNOS may be potential therapeutic agents for clinical application in patients with acute respiratory distress syndrome...
  62. pmc The functional nitrite reductase activity of the heme-globins
    Mark T Gladwin
    Pulmonary and Vascular Medicine Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA
    Blood 112:2636-47. 2008
    ..We will review these reactions in the biologic framework of hypoxic signaling in blood and the heart...
  63. pmc Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction
    Felix M Gonzalez
    Translational Medicine Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892 1061, USA
    Circulation 117:2986-94. 2008
    ....
  64. ncbi Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy
    K V H Sastry
    Division of Physiology and Reproduction, Central Avian Research Institute, Uttar Pradesh, India
    Anal Biochem 306:79-82. 2002
    ..The present method provides a simple, cost-effective assay for the estimation of stable oxidation products of nitric oxide in biological samples...
  65. ncbi Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction
    Enika Nagababu
    Molecular Dynamics Section, National Institute on Aging NIH, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA
    J Biol Chem 278:46349-56. 2003
    ..The formation and potential release from the red cell of this NO could have a major impact in regulating the flow of blood through the microcirculation...
  66. pmc Erythrocytes are the major intravascular storage sites of nitrite in human blood
    Andre Dejam
    Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 106:734-9. 2005
    ..These studies suggest a dynamic intravascular NO metabolism in which endothelial NOS-derived NO is stabilized as nitrite, transported by erythrocytes, and consumed during arterial-to-venous transit...
  67. ncbi Hyperglycaemia-induced superoxide production decreases eNOS expression via AP-1 activation in aortic endothelial cells
    S Srinivasan
    Division of Endocrinology and Metabolism, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Diabetologia 47:1727-34. 2004
    ..The aim of this study was to investigate the regulation of endothelial nitric oxide synthase (eNOS) activity by acute and chronic elevated glucose...
  68. ncbi Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase
    Pinpat Tripatara
    Centre for Experimental Medicine and Nephrology and Critical Care, William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, EC1M 6BQ, UK
    J Am Soc Nephrol 18:570-80. 2007
    ..These observations suggest that nitrite therapy might prove beneficial in protecting kidney function and integrity during periods of I/R such as those encountered in renal transplantation...
  69. pmc Enrichment and molecular detection of denitrifying methanotrophic bacteria of the NC10 phylum
    Katharina F Ettwig
    Department of Microbiology, Institute for Water and Wetland Research, Radboud University Nijmegen, The Netherlands
    Appl Environ Microbiol 75:3656-62. 2009
    ....
  70. ncbi N2 production by the anammox reaction in the anoxic water column of Golfo Dulce, Costa Rica
    Tage Dalsgaard
    Department of Marine Ecology, National Environmental Research Institute, Vejlsøvej 25 PO Box 314, DK 8600 Silkeborg, Denmark
    Nature 422:606-8. 2003
    ..We therefore expect the anammox reaction to be a globally significant sink for oceanic nitrogen...
  71. ncbi Isolation of an autotrophic ammonia-oxidizing marine archaeon
    Martin Könneke
    Department of Civil and Environmental Engineering, University of Washington, Seattle, Washington 98195, USA
    Nature 437:543-6. 2005
    ..The autotrophic metabolism of this isolate, and its close phylogenetic relationship to environmental marine crenarchaeal sequences, suggests that nitrifying marine Crenarchaeota may be important to global carbon and nitrogen cycles...
  72. ncbi Kinetics of reaction of nitrite with deoxy hemoglobin after rapid deoxygenation or predeoxygenation by dithionite measured in solution and bound to the cytoplasmic domain of band 3 (SLC4A1)
    James M Salhany
    Departments of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, 984510 Nebraska Medical Center, Omaha, Nebraska 68198 4510, USA
    Biochemistry 47:6059-72. 2008
    ....
  73. pmc Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury
    Nathan S Bryan
    Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:19144-9. 2007
    ..Therefore, nitrite and nitrate may serve as essential nutrients for optimal cardiovascular health and may provide a treatment modality for cardiovascular disease...
  74. pmc Nitrosatable drug exposure during the first trimester of pregnancy and selected congenital malformations
    Jean D Brender
    Texas A and M Health Science Center, School of Rural Public Health, College Station, Texas 77843 1266, USA
    Birth Defects Res A Clin Mol Teratol 94:701-13. 2012
    ..With data from the National Birth Defects Prevention Study, the relation between prenatal exposure to nitrosatable drugs and limb deficiencies, oral cleft, and heart malformations in offspring was examined...
  75. ncbi D-Lactate metabolism and the obligate requirement for CO2 during growth on nitrite by the facultative lithoautotroph Nitrobacter hamburgensis
    Shawn R Starkenburg
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    Microbiology 154:2473-81. 2008
    ..75 mM sodium carbonate was required for mixotrophic growth and for optimum organotrophic growth on D-lactate...
  76. ncbi A single channel for nitrate uptake, nitrite export and nitrite uptake by Escherichia coli NarU and a role for NirC in nitrite export and uptake
    Wenjing Jia
    School of Biosciences, University of Birmingham, Birmingham B152TT, UK
    Biochem J 417:297-304. 2009
    ..We propose that NarU functions as a single channel for nitrate uptake and nitrite expulsion, either as a nitrate-nitrite antiporter, or more likely as a nitrate/H+ or nitrite/H+ channel...
  77. ncbi Smoking a single cigarette rapidly reduces combined concentrations of nitrate and nitrite and concentrations of antioxidants in plasma
    Masahiko Tsuchiya
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, Abenoku, Osaka, Japan
    Circulation 105:1155-7. 2002
    ....
  78. ncbi Microbial community distribution and activity dynamics of granular biomass in a CANON reactor
    Jose Vázquez-Padín
    Department of Chemical Engineering, University of Santiago de Compostela, Lope Gómez de Marzoa, S N, E 15782, Spain
    Water Res 44:4359-70. 2010
    ....
  79. ncbi A microbial consortium couples anaerobic methane oxidation to denitrification
    Ashna A Raghoebarsing
    Department of Microbiology, Institute for Water and Wetland Research, Radboud University Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, The Netherlands
    Nature 440:918-21. 2006
    ..The detection of relatives of these prokaryotes in different freshwater ecosystems worldwide indicates that the reaction presented here may make a substantial contribution to biological methane and nitrogen cycles...
  80. ncbi Effect of nitrite concentration on the distribution and competition of nitrite-oxidizing bacteria in nitratation reactor systems and their kinetic characteristics
    Dong Jin Kim
    Department of Environmental Sciences and Biotechnology, Hallym University, 1 Okchon, Chunchon, Kangwon 200 702, Republic of Korea
    Water Res 40:887-94. 2006
    ..It seems that nitrite load and starvation conditions do not give a direct effect on the distribution of NOB...
  81. ncbi Relevance of Nitrospira for nitrite oxidation in a marine recirculation aquaculture system and physiological features of a Nitrospira marina-like isolate
    Sabine Keuter
    Biozentrum Klein Flottbek, Universitat Hamburg, Mikrobiologie und Biotechnologie, Ohnhorststr 18, D 22609 Hamburg, Germany
    Environ Microbiol 13:2536-47. 2011
    ..Both members of Nitrospira could be detected by PCR-based methods in environmental samples of marine and brackish RAS biofilters and are therefore considered to be characteristic for these engineered ecosystems...
  82. ncbi Competition between Nitrospira spp. and Nitrobacter spp. in nitrite-oxidizing bioreactors
    Regina Nogueira
    Centro de Engenharia Biológica Universidade do Minho, Campus de Gualtar, 4700 057 Braga, Portugal
    Biotechnol Bioeng 95:169-75. 2006
    ..An alternative explanation would be that the length of the experimental period was not long enough to observe an increase of the Nitrospira population...
  83. ncbi Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation
    Mark T Gladwin
    Vascular Medicine Branch, National Heart Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892 1454, USA
    Am J Physiol Heart Circ Physiol 291:H2026-35. 2006
    ..An expanded consideration of nitrite as a hypoxia-dependent intrinsic signaling molecule has opened up a new field of research and therapeutic opportunities for diseases associated with regional hypoxia and vasoconstriction...
  84. ncbi Oxidative stress in rat hippocampus caused by pilocarpine-induced seizures is reversed by buspirone
    Rizângela Lyne Mendes de Freitas
    Course of Pharmacy of Catholic Faculty Rainha do Sertão, Quixada, Ceara, CE, Brazil
    Brain Res Bull 81:505-9. 2010
    ..Buspirone exerted anticonvulsant effects associated with the inhibition of the development of oxidative stress. These results suggest a therapeutic use potential of buspirone in epilepsy treatment...
  85. ncbi Cardioprotective effects of vegetables: is nitrate the answer?
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet 171 77, Stockholm, Sweden
    Nitric Oxide 15:359-62. 2006
    ....
  86. pmc Magnetic resonance study of the transmembrane nitrite diffusion
    A Samouilov
    Center for Biomedical EPR Spectroscopy and Imaging, The Davis Heart and Lung Research Institute, The Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA
    Nitric Oxide 16:362-70. 2007
    ..8 to 24.7 microM after nitrite perfusion. Physiological significance of passive transmembrane transport of NO(2)- and its coupling with intraliposomal acidification are discussed...
  87. ncbi Electricity production coupled to ammonium in a microbial fuel cell
    Zhen He
    Department of Earth Sciences, University of Southern California, Los Angeles, California 90089, USA
    Environ Sci Technol 43:3391-7. 2009
    ..The present MFC achieved an ammonium removal efficiency of 49.2 +/- 5.9 or 69.7 +/- 3.6%, depending on hydraulic retention time, but exhibited a very low Coulombic efficiency...
  88. ncbi Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin
    Swati Basu
    Department of Physics, Wake Forest University, 1834 Wake Forest Road, Winston Salem, North Carolina 27109, USA
    Nat Chem Biol 3:785-94. 2007
    ....
  89. ncbi Anaerobic phototrophic nitrite oxidation by Thiocapsa sp. strain KS1 and Rhodopseudomonas sp. strain LQ17
    Joachim Schott
    Microbial Ecology, Department of Biology, Universitat Konstanz, D 78465 Konstanz, Germany
    Microbiology 156:2428-37. 2010
    ..We conclude that the ability to use nitrite phototrophically as electron donor is widespread in nature, but low MPN counts indicate that its contribution to nitrite oxidation in the studied habitats is rather limited...
  90. pmc Nitric oxide promotes distant organ protection: evidence for an endocrine role of nitric oxide
    John W Elrod
    Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 105:11430-5. 2008
    ..This study presents clear evidence for an endocrine role of NO generated endogenously from eNOS and provides additional evidence for the profound cytoprotective actions of NO in the setting of I/R injury...
  91. pmc Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
    Dario A Vitturi
    Dept of Pathology, Univ of Alabama at Birmingham, 901 19th St S, BMR 2, Rm 302, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 296:H1398-407. 2009
    ....
  92. ncbi Orally administered nitrite attenuates cardiac allograft rejection in rats
    Jianghua Zhan
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Surgery 146:155-65. 2009
    ..Recent studies have shown that nitrite serves as an endogenous reservoir of nitric oxide (NO), particularly in the presence of hypoxia and ischemia. We hypothesized that exogenous nitrite supplementation would protect cardiac allografts...
  93. ncbi Oxidative stress and nitrite dynamics under maximal load in elite athletes: relation to sport type
    Dejan Cubrilo
    Department of Physiology, Faculty of Medicine, University of Kragujevac, Svetozara Markovica 69, PO Box 124, 34000 Kragujevac, Republic of Serbia
    Mol Cell Biochem 355:273-9. 2011
    ..Concentrations of lactates, nitric oxide (NO) measured through stabile end product-nitrites (NO(2) (-)), superoxide anion radical (O(2) (•-)), and thiobarbituric reactive substances (TBARS) as index of ..
  94. pmc Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage
    Andrew Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and The London, Queen Mary s School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, England
    Proc Natl Acad Sci U S A 101:13683-8. 2004
    ..Hence, if XOR is presented with NO(2)(-) as an alternative substrate, the resultant effects of its activity may be protective, by means of its production of NO. , rather than damaging...
  95. pmc Effects of a potent peroxynitrite decomposition catalyst in murine models of endotoxemia and sepsis
    Francisco Garcia Soriano
    Laboratório da Disciplina de Emergências Clínicas, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil
    Shock 35:560-6. 2011
    ..The current data support the view that peroxynitrite is a critical factor mediating liver, gut, and lung injury in endotoxemia and septic shock: its pharmacological neutralization may be of therapeutic benefit...
  96. pmc Biphasic behavior of anammox regulated by nitrite and nitrate in an estuarine sediment
    Mark Trimmer
    School of Biological Sciences, Queen Mary, University of London, London E1 4NS, United Kingdom
    Appl Environ Microbiol 71:1923-30. 2005
    ..Overall, anammox is likely to be regulated by the availability of NO3- and NO2- and the relative size or activity of the anammox population...
  97. ncbi Anoxic nitric oxide cycling in plants: participating reactions and possible mechanisms
    Abir U Igamberdiev
    Department of Biology, Memorial University of Newfoundland, St John s, NL, A1B 3X9, Canada
    Physiol Plant 138:393-404. 2010
    ..In normoxic conditions, NO is produced in very low quantities, mainly for signaling purposes and this nitrogen cycling is inoperative...
  98. ncbi Anaerobic ammonium oxidation (anammox) in Chesapeake Bay sediments
    Jeremy J Rich
    Department of Geosciences, Princeton University, Princeton, New Jersey, USA
    Microb Ecol 55:311-20. 2008
    ..A total of 35 anammox-like sequences were detected, and phylogenetic analysis grouped the sequences in two distinct clusters belonging to the Candidatus "Scalindua" genus...
  99. pmc Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling
    Carlo G Tocchetti
    Cardiology Division, Johns Hopkins Medical Institutions, 720 Rutland Ave, Baltimore, MD 21205, USA
    Circ Res 100:96-104. 2007
    ..Rather, the data support HNO/thiolate interactions that enhance the activity of intracellular Ca(2+) cycling proteins. These findings suggest HNO donors are attractive candidates for the pharmacological treatment of heart failure...
  100. pmc Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase
    Andrew J Webb
    William Harvey Research Institute, Centre for Clinical Pharmacology, Barts and The London, Charterhouse Square, London, UK
    Circ Res 103:957-64. 2008
    ....
  101. ncbi Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats
    Kevin S Shaughnessy
    Department of Biology, University of Prince Edward Island, Charlottetown, PEI, Canada C1A 4P3
    Nutr Res 29:130-8. 2009
    ..Blueberry-fed rats had reduced markers of renal oxidative stress, such as proteinuria and kidney nitrites. Thus, a 3% BB diet may be capable of protecting the kidneys from oxidative damage in SHRSP, thereby reducing the ..

Research Grants62

  1. Toxicokinetics and Toxicodynamics of Nitrite Inhalants
    Ho Leung Fung; Fiscal Year: 2005
    ..therefore seek to test the following hypotheses: (1) that the toxicokinetics and vasodilatory effects of inhalant nitrites are affected by repeated exposure, (2) that inhalant nitrites alter the regulation of angiogenesis genes, and ..
  2. Role of Insulin Receptors in the Kidney
    CAROLYN MARY ECELBARGER; Fiscal Year: 2013
    ..impaired in their ability to rapidly excrete a NaCl load, as well as, have blunted rise in urinary nitrates plus nitrites (a urinary form of NO) excretion in the basal state and after insulin treatment...
  3. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..g. pesticides), as well as trace amounts of hazardous materials such as arsenic, perchlorate, nitrates and nitrites. Currently, the majority of common household point-of-entry water purification systems mainly consist of a carbon ..
  4. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..Bronchoalveolar (BAL) and lung mediators increased after i.t. LPS, among them BAL nitrites/nitrates (NOx)...
  5. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2013
    ..Bronchoalveolar (BAL) and lung mediators increased after i.t. LPS, among them BAL nitrites/nitrates (NOx)...
  6. Nitrites as Antidotes for Hydrogen Sulfide Poisoning
    James Peterson; Fiscal Year: 2013
    ..abstract_text> ..
  7. Acute Cyanide Toxicity, Complex IV, NO & Nitrite
    James Peterson; Fiscal Year: 2010
    ..Enthusiasm for the use of traditional antidotes, nitrites (amyl and/or sodium nitrite), has decreased, in part, because of the uncertain assumption that its mechanism of ..
  8. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
    ..chemical exposures, and from pharmaceutical agents such as local anesthetics, acetaminophen, and drugs containing nitrites and/or nitrates...
  9. STEROIDS /VASCULAR REACTIVITY /NITRIC OXIDE PRODUCTION
    Maureen Keller Wood; Fiscal Year: 2002
    ..Experiments will also determine plasma levels of nitrates and nitrites and the ability of infusion of L-NAME, an inhibitor of nitric oxide synthase (NOS), to increase vascular ..
  10. BEHAVIORAL PHARMACOLOGY OF ABUSED SOLVENTS
    Robert Balster; Fiscal Year: 1992
    ..This will include further research with the abused volatile nitrites. We propose to study the anti- anxiety effects of inhalants by determining their ability to block a ..
  11. Nitric Oxide Donor Compounds for the Treatment of Hemolytic Conditions
    DANIEL KIM SHAPIRO; Fiscal Year: 2009
    ..Lead compounds to be studied include NONOates (NO donors), nitroxyl donors and possibly nitrated lipids and nitrites. A variety of biophysical methods are proposed to test the potential efficacy of the synthesized compounds ..
  12. Low Cost Automated Urinalysis using Spectral Data
    Fatima Merchant; Fiscal Year: 2005
    ..Routine urinalysis consists of a physical (color, clarity, odor), chemical (protein, glucose, nitrites, etc.), and microscopic examination (cells, crystals, bacteria, etc.) of the urine...
  13. STRUCTURE-FUNCTION RELATIONSHIP OF HEMOGLOBIN A
    Ali Mansouri; Fiscal Year: 1980
    ..in methemoglobin reduction; and 2) although most of the IHP inhibitory effect on the oxidation of hemoglobin by nitrites is due to the shift of the molecular conformation towards T, not all of its effect can be explained in this ..
  14. Club drug use/sexual risk-taking among Latino/other MSM
    JOHN ECHEVERRY; Fiscal Year: 2007
    ..methylenedioxymethamphetamine (MDMA, or Ecstasy), ketamine (Special K), gamma hydroxybutyrate (GHB), and volatile nitrites (poppers)...
  15. INTESTINAL METAPLASIA, ASCORBATE, AND H PYLORI
    Julie Parsonnet; Fiscal Year: 1993
    ..cell proliferation, increased production of inflammation-related free radicals, and increased N-nitrosation of nitrites. We further hypothesize that these latter two effects are in part attributable to H...
  16. NITRIC OXIDE EFFECTS ON CARDIOVASCULAR REACTIVITY
    Diane Tucker; Fiscal Year: 2002
    ..psychophysiologic testing with measures of BP, forearm blood flow, and plasma levels of NO metabolites (nitrates/nitrites) and catecholamines taken before and after two stressors (speech task and cold pressor)...
  17. HIV RISK AND CLUB DRUGS AMONG MSM--A TWO CITY COMPARISON
    Patricia Case; Fiscal Year: 2002
    ..Club drugs include a number of previously studied substances such as methamphetamine and inhaled nitrites, as well as a number of relatively new and as yet unexamined substances such as ketamine and MDMA...
  18. IMMUNOTOXICITY OF ABUSED NITRITE INHALANTS
    Lee Soderberg; Fiscal Year: 2000
    DESCRIPTION: (Applicant's Abstract) Amyl, isobutyl, butyl and cyclohexyl nitrites are volatile chemicals, which are abused by inhalation. Abuse of nitrite inhalants is particularly widespread among homosexuals...
  19. Educational Strategies to Prevent Abuse of Household Chemicals
    Karen Graf; Fiscal Year: 2009
    Inhalants, which include aerosols, volatile liquids, gases, and nitrites, have found increasing use as mind-altering drugs especially among middle school- and high school-aged children...
  20. Asian Men's Health Study
    Kyung Hee Choi; Fiscal Year: 2005
    ..Our recent work with 18- to 29-year-old API MSM revealed that using ecstasy and inhalant nitrites during sex was associated with unprotected anal intercourse, whereas using marijuana, gamma-hydroxybutyrate, and ..
  21. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..The few epidemiologic studies conducted in the past have focused on the separate effects of nitrates, nitrites, and nitrosatable drugs on risk of congenital malformations without consideration of their interaction in the ..
  22. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  23. Role of nitric oxide and eicosanoids in lupus nepthritis
    James Oates; Fiscal Year: 2005
    ..In either event, future studies would address the use of selective COX-2 or TXA2 synthase inhibitors/receptor blockers, antioxidants, and/or PGI2/PGE2 agonists in conduction with iNOS inhibitors as therapies for LN. ..
  24. Gene-Environment Factors in Childhood Brain Tumors
    Beth Mueller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  26. Urine protein markers of disease in lupus nephritis
    James Oates; Fiscal Year: 2005
    ..Due to the power of proteomic and ANN techniques, novel mediators of disease activity and damage should be identified and thus contribute to the development of more targeted therapies for LN. ..
  27. Case-Control Study of Head Injury in Relation to Ski He*
    Beth Mueller; Fiscal Year: 2005
    ..abstract not provided ..
  28. Smoking During Pregnancy and Breast Cancer
    Beth Mueller; Fiscal Year: 2003
    ....
  29. Use of Water Quality Surveillance Data in Epidemiologic*
    Beth Mueller; Fiscal Year: 2003
    ..These methods may also be applicable to environmental databases with other types of exposures, or for examining other exposures (like pesticides) within drinking water surveillance databases. ..
  30. Assessment of the Chemical Biology of HNO via New Donors
    Katrina M Miranda; Fiscal Year: 2010
    ..Additionally, new biological targets, such as zinc fingers and non-heme iron centers, are likely to be revealed, which may suggest other therapeutic interventions. ..
  31. Methamphetamine Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2006
    ....
  32. Immortalized Human Cavernosal Endothelial Cells
    Hunter Wessells; Fiscal Year: 2005
    ..abstract_text> ..
  33. Effects of Nitric Oxide in Sickle Cell Blood
    DANIEL KIM SHAPIRO; Fiscal Year: 2006
    ..Our studies will help us understand important issues related to NO's role in sickle cell disease and in the general population. ..
  34. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  35. CHRONIC HYPOXIA AND RESISTANCE TO MYOCARDIAL ISCHEMIA
    John E Baker; Fiscal Year: 2010
    ..The results of these studies are expected to have an impact on our understanding of the biology of Tpo in heart and may lead to the development of new therapeutics for the treatment of myocardial infarction. ..
  36. Inflammation in obesity: Modulation by Weight Loss
    Paresh Dandona; Fiscal Year: 2009
    ..abstract_text> ..
  37. FETAL HYPOXEMIA AND ENDOTHELIUM DERIVED NITRIC OXIDE
    Loren P Thompson; Fiscal Year: 2010
    ..We propose that hypoxia alters NOS expression in the fetal heart contributing to adaptive and maladaptive responses, both pre- and postnatally. This will identify iNOS-derived NO synthesis as a target pathway for fetal survival. ..
  38. Pain and drug abuse in HIV: Impact on health services
    JENNIE TSAO; Fiscal Year: 2005
    ..The proposed research agenda encompasses a set of analyses that will provide valuable insights into the health and well being of IDUs and drug dependent patients in care for HIV. ..
  39. Aromatic amino acid metabolism in the pathogenesis of kwashiorkor
    Farook Jahoor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. GENETICS AND INTERMITTENT MYOCARDIAL HYPOXIA
    John Baker; Fiscal Year: 2003
    ....
  41. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..alternative NOS-independent mechanism of NO formation in the nervous system, the non-enzymatic NO synthesis from nitrites in acidified and reducing micro-environments...
  42. EFFECT OF COMP MUTATION ON MUSCULOSKELETAL DEVELOPMENT
    Paul Di Cesare; Fiscal Year: 2002
    ..Identifying the functions, synthesis, interactions, tissue distribution and expression of COMP is critical to understanding its influence on growth during endochondral ossification and articular cartilage structure and function. ..
  43. IN VIVO EPR IMAGING OF FREE RADICALS AT 300 MHZ
    Jay Zweier; Fiscal Year: 2001
    ....
  44. CARCINOGENESIS--HIGHLY REACTIVE NITROSAMINES
    RICHARD LOEPPKY; Fiscal Year: 2001
    ....
  45. Distal Lung Inflammation Effect on Asthma Exacerbations
    Donald Tashkin; Fiscal Year: 2008
    ..This study has the potential to clarify the contribution of the "silent zone" to the persistent morbidity encountered with asthma. ..
  46. Proton Electron Double Resonance Imaging (PEDRI) of Free Radicals
    Jay Zweier; Fiscal Year: 2008
    ..abstract_text> ..
  47. Chemokine Blockade to Preserve Lung Development
    Richard Auten; Fiscal Year: 2005
    ..Aim 3 will determine whether blockade of leukocyte function can safely preserve normal alveolar development during recovery from severe oxidant stress. ..
  48. MDMA Neurotoxicity in Nonhuman Primates
    George Ricaurte; Fiscal Year: 2005
    ..abstract_text> ..
  49. Inhibition of Macrophage Activation by Smad3
    Mark Feinberg; Fiscal Year: 2005
    ..Insight into the mechanism governing SmadYs role in inflammation may provide potential, therapeutic targets applicable to a number of inflammatory diseases. ..
  50. Inhalant Abuse and Dependence
    Ty Ridenour; Fiscal Year: 2004
    ..Abuse Module (SAM) questions specifically for the different types of inhalants (solvents, aerosols, gases, and nitrites) and to quantitatively estimate the psychometrics of a general inhalants category of abuse and dependence ..
  51. SEVERE MALARIAL ANEMIA AND ALTERED IMMUNE FUNCTION
    Victor Gordeuk; Fiscal Year: 2004
    ..The nutritional status, underlying parasitic infections, and genotypes and numbers of infecting P. falciparum strains will also be characterized. ..
  52. MDMA Neurotoxicity in Humans: Occurence & Consequences
    George Ricaurte; Fiscal Year: 2006
    ....
  53. SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES
    Neil Hogg; Fiscal Year: 2006
    ..The success of the program will be closely monitored by follow-up questionnaires to both students and participating faculty. ..
  54. Dietary Fiber and Cardiovascular Inflammatory Markers
    Dana King; Fiscal Year: 2006
    ..This information could serve to guide constructive changes in nutritional guidelines for reducing CVD risk for millions of at-risk individuals. ..
  55. ADHD Treatment & Amphetamine Neurotoxicity
    George Ricaurte; Fiscal Year: 2007
    ....
  56. Flavonoid Modulation of Epithelial Migration and Signal*
    NORMAN HORD; Fiscal Year: 2004
    ..Ultimately, this research will provide critical information necessary for specific and rational dietary recommendations to decrease colon cancer risk in humans. ..
  57. ENDOGENOUS NITROSATION CHEMISTRY IN CARCINOGENESIS
    RICHARD LOEPPKY; Fiscal Year: 2004
    ..Computational methods will be employed to reveal reaction paths of intermediates and lead to better predictions of the types of compounds which pose a carcinogenic threat through their endogenous nitrosation. ..
  58. Clinical Features in Nursing Home Residents with Suspected UTI
    Manisha Juthani Mehta; Fiscal Year: 2008
    ..This study will create an evidence-based definition of UTI. Future studies will identify residents with UTI in whom antibiotic therapy improves clinical outcome. [unreadable] [unreadable] [unreadable]..
  59. Howard-CNMC Sickle Cell Disease Clinical Center
    Victor Gordeuk; Fiscal Year: 2008
    ..A major feature of both sickle cell programs has always been continuity of care and participation in collaborative research. ..
  60. Neural Melanocortin Signaling and Erectile Function
    Hunter Wessells; Fiscal Year: 2005
    ..The findings may allow us to develop receptor-specific therapeutic strategies, which may ultimately be beneficial to men and women with sexual dysfunction. ..