nitriles

Summary

Summary: Organic compounds containing the -CN radical. The concept is distinguished from CYANIDES, which denotes inorganic salts of HYDROGEN CYANIDE.

Top Publications

  1. ncbi The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    Daniel J Drucker
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Lancet 368:1696-705. 2006
  2. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
  3. ncbi Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer
    Ann H Partridge
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:556-62. 2008
  4. ncbi Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial
    V Lukashevich
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936 1080, USA
    Diabetes Obes Metab 13:947-54. 2011
  5. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
  6. ncbi Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)
    B D Brooke
    Medical Entomology, Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the South African Institute for Medical Research, Johannesburg, 2000, South Africa
    Bull Entomol Res 91:265-72. 2001
  7. ncbi Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    N Matikainen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    Diabetologia 49:2049-57. 2006
  8. ncbi Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    Jose Baselga
    Medical Oncology Department, Vall d Hebron University Hospital, P Vall d Hebron, Barcelona, Spain
    J Clin Oncol 27:2630-7. 2009
  9. ncbi Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
  10. ncbi Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 11:1135-41. 2010

Research Grants

Detail Information

Publications391 found, 100 shown here

  1. ncbi The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
    Daniel J Drucker
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Lancet 368:1696-705. 2006
    ..However, long-term clinical studies are needed to determine the benefits of targeting the incretin axis for the treatment of type 2 diabetes...
  2. ncbi Pyrethroid tolerance is associated with elevated expression of antioxidants and agricultural practice in Anopheles arabiensis sampled from an area of cotton fields in Northern Cameroon
    Pie Müller
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Mol Ecol 17:1145-55. 2008
    ..These genes may constitute an important general defence mechanism against insecticides. Intriguingly, the levels of expression of these genes were strongly correlated suggesting a common regulatory mechanism...
  3. ncbi Adherence to initial adjuvant anastrozole therapy among women with early-stage breast cancer
    Ann H Partridge
    Dana Farber Cancer Institute, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:556-62. 2008
    ..Previous research evaluating adherence to tamoxifen therapy among women with early-stage breast cancer has revealed adherence estimates ranging from 25% to 96%. No previous studies have focused on adherence to adjuvant aromatase inhibitors...
  4. ncbi Safety and efficacy of vildagliptin versus placebo in patients with type 2 diabetes and moderate or severe renal impairment: a prospective 24-week randomized placebo-controlled trial
    V Lukashevich
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936 1080, USA
    Diabetes Obes Metab 13:947-54. 2011
    ..Assess safety/tolerability and efficacy of the DPP-4 inhibitor vildagliptin in 515 patients with type 2 diabetes mellitus (T2DM) and moderate or severe renal impairment (RI)...
  5. ncbi Insecticide resistance and its association with target-site mutations in natural populations of Anopheles gambiae from eastern Uganda
    Urvashi Ramphul
    Vector Group, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK
    Trans R Soc Trop Med Hyg 103:1121-6. 2009
    ..Intriguingly, the association between DDT resistance and the presence of L1014S is consistent with a co-dominant effect, with heterozygous individuals showing an intermediate phenotype...
  6. ncbi Bioassay and biochemical analyses of insecticide resistance in southern African Anopheles funestus (Diptera: Culicidae)
    B D Brooke
    Medical Entomology, Department of Clinical Microbiology and Infectious Diseases, School of Pathology of the South African Institute for Medical Research, Johannesburg, 2000, South Africa
    Bull Entomol Res 91:265-72. 2001
    ..The data suggested that this mechanism was also conferring cross-resistance to the carbamate insecticide propoxur...
  7. ncbi Vildagliptin therapy reduces postprandial intestinal triglyceride-rich lipoprotein particles in patients with type 2 diabetes
    N Matikainen
    Division of Cardiology, Department of Medicine, Helsinki University Central Hospital and Biomedicum, Helsinki, Finland
    Diabetologia 49:2049-57. 2006
    ..We assessed the effects of vildagliptin, a novel dipeptidyl peptidase IV inhibitor, on postprandial lipid and lipoprotein metabolism in patients with type 2 diabetes...
  8. ncbi Phase II randomized study of neoadjuvant everolimus plus letrozole compared with placebo plus letrozole in patients with estrogen receptor-positive breast cancer
    Jose Baselga
    Medical Oncology Department, Vall d Hebron University Hospital, P Vall d Hebron, Barcelona, Spain
    J Clin Oncol 27:2630-7. 2009
    ..This study explored whether sensitivity to letrozole was enhanced with the oral mTOR inhibitor, everolimus (RAD001)...
  9. ncbi Vildagliptin enhances islet responsiveness to both hyper- and hypoglycemia in patients with type 2 diabetes
    Bo Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    J Clin Endocrinol Metab 94:1236-43. 2009
    ..However, their effects on the glucagon response to hypoglycemia are not established...
  10. ncbi Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 10-year analysis of the ATAC trial
    Jack Cuzick
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, Queen Mary School of Medicine and Dentistry, University of London, London, UK
    Lancet Oncol 11:1135-41. 2010
    ..In this analysis, we assess the long-term outcomes after a median follow-up of 120 months...
  11. pmc Glutathione S-transferases as antioxidant defence agents confer pyrethroid resistance in Nilaparvata lugens
    J G Vontas
    School of Biosciences, Cardiff University, Main College, Museum Avenue, P O Box 915, Cardiff CF10 3TL, Wales, UK
    Biochem J 357:65-72. 2001
    ..lugens is through protecting tissues from oxidative damage. Our study extends the GSTs' range of efficacy to pyrethroid insecticides and possibly explains the role of elevated GSTs in other pyrethroid-resistant insects...
  12. pmc Reduced efficacy of insecticide-treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin
    Vincent Corbel
    London School of Hygiene and Tropical Medicine, Cotonou, Benin, West Africa
    Emerg Infect Dis 13:199-206. 2007
    ..Pyrethroid resistance in An. gambiae appears to threaten the future of ITN and IRS in Benin...
  13. ncbi Prognostic value of Ki67 expression after short-term presurgical endocrine therapy for primary breast cancer
    Mitch Dowsett
    Academic Department of Biochemistry, 4th Floor, Wallace Wing, The Royal Marsden Hospital, Fulham Road, London SW3 6 JJ, UK
    J Natl Cancer Inst 99:167-70. 2007
    ....
  14. ncbi Addition of vildagliptin to insulin improves glycaemic control in type 2 diabetes
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Diabetologia 50:1148-55. 2007
    ..This study assessed the efficacy and tolerability of vildagliptin added to insulin therapy in patients with type 2 diabetes...
  15. ncbi A significant increase in kdr in Anopheles gambiae is associated with an intensive vector control intervention in Burundi highlands
    Natacha Protopopoff
    Department of Parasitology, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    Trop Med Int Health 13:1479-87. 2008
    ..l.) was determined for six consecutive years within the framework of a vector control programme. Findings were also linked with the insecticide resistance status observed with bioassay in An. gambiae s.l. and An. funestus...
  16. ncbi Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study
    Bella Kaufman
    Chaim Sheba Medical Center, Tel Hashomer, Israel
    J Clin Oncol 27:5529-37. 2009
    ..TAnDEM is the first randomized phase III study to combine a hormonal agent and trastuzumab without chemotherapy as treatment for human epidermal growth factor receptor 2 (HER2)/hormone receptor-copositive metastatic breast cancer (MBC)...
  17. pmc Randomized phase II neoadjuvant comparison between letrozole, anastrozole, and exemestane for postmenopausal women with estrogen receptor-rich stage 2 to 3 breast cancer: clinical and biomarker outcomes and predictive value of the baseline PAM50-based int
    Matthew J Ellis
    Siteman Cancer Center, Washington University in St Louis, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Clin Oncol 29:2342-9. 2011
    ..To study this treatment option, responses to three AIs were compared in a randomized phase II neoadjuvant trial designed to select agents for phase III investigations...
  18. ncbi Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor gamma (PPARgamma ) and C/EBPalpha gene expression during the differentiation of 3T3-L1 preadipocytes
    Deepanwita Prusty
    Department of Biochemistry, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 277:46226-32. 2002
    ..Our results suggest that activation of the MEK/ERK signaling pathway during the initial 12 h of adipogenesis enhances the activity of factors that regulate both C/EBPalpha and PPARgamma expression...
  19. ncbi Global target profile of the kinase inhibitor bosutinib in primary chronic myeloid leukemia cells
    L L Remsing Rix
    Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria
    Leukemia 23:477-85. 2009
    ..Finally, bosutinib is the first kinase inhibitor shown to target CAMK2G, recently implicated in myeloid leukemia cell proliferation...
  20. ncbi Mechanisms of action of the dipeptidyl peptidase-4 inhibitor vildagliptin in humans
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden Novartis Pharma AG, Basel, Switzerland
    Diabetes Obes Metab 13:775-83. 2011
    ....
  21. pmc Mitotic clonal expansion: a synchronous process required for adipogenesis
    Qi Qun Tang
    Department of Biological Chemistry, Division of Endocrinology, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 100:44-9. 2003
    ..These results show that MCE is a prerequisite for differentiation of 3T3-L1 preadipocytes into adipocytes...
  22. ncbi In vitro and in vivo activity of SKI-606, a novel Src-Abl inhibitor, against imatinib-resistant Bcr-Abl+ neoplastic cells
    Miriam Puttini
    Department of Clinical Medicine, S Gerardo Hospital University of Milano Bicocca, Monza, Italy
    Cancer Res 66:11314-22. 2006
    ..Modeling considerations attribute the superior activity of SKI-606 to its ability to bind a conformation of Bcr-Abl different from imatinib...
  23. ncbi Assessing the cardio-cerebrovascular safety of vildagliptin: meta-analysis of adjudicated events from a large Phase III type 2 diabetes population
    A Schweizer
    Novartis Pharma AG, Basel, Switzerland
    Diabetes Obes Metab 12:485-94. 2010
    ..To assess the cardiovascular and cerebrovascular (CCV) safety of the dipeptidyl peptidase-IV inhibitor vildagliptin...
  24. ncbi Phase III study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the International Letrozole Breast Cancer Group
    Henning Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 21:2101-9. 2003
    ..To analyze overall survival (OS) and update efficacy data for letrozole versus tamoxifen as first-line therapy in postmenopausal women with locally advanced or metastatic breast cancer...
  25. pmc Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system
    Z Culig
    Department of Urology, University of Innsbruck, Austria
    Br J Cancer 81:242-51. 1999
    ..These findings may have repercussions on the natural course of prostate cancer with androgen deprivation and on strategies of therapeutic intervention...
  26. ncbi ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 22:478-85. 2002
    ..Activation of the ERK pathway in a subset of nociceptive spinal neurons contributes, therefore, to persistent pain hypersensitivity, possibly via transcriptional regulation of genes, such as prodynorphin and NK-1...
  27. ncbi Synergistic interactions between in-hive miticides in Apis mellifera
    Reed M Johnson
    Department of Entomology, 320 Morrill Hall, University of Illinois, 505 S Goodwin, Urbana, IL 61801 3795, USA
    J Econ Entomol 102:474-9. 2009
    ..These results suggest that honey bee mortality may occur with the application of otherwise sublethal doses of miticide when tau-fluvalinate and coumaphos are simultaneously present in the hive...
  28. ncbi Superior efficacy of letrozole versus tamoxifen as first-line therapy for postmenopausal women with advanced breast cancer: results of a phase III study of the International Letrozole Breast Cancer Group
    H Mouridsen
    Rigshospitalet, Copenhagen, Denmark
    J Clin Oncol 19:2596-606. 2001
    ..CONCLUSION: Letrozole was significantly superior to tamoxifen in TTP, TTF, ORR, and clinical benefit rate. Our results support its use as first-line endocrine therapy in postmenopausal women with advanced breast cancer...
  29. ncbi Dual inhibition of mTOR and estrogen receptor signaling in vitro induces cell death in models of breast cancer
    Anne Boulay
    Novartis Institutes for BioMedical Research Basel, Oncology Research, Novartis Pharma AG, Basel, Switzerland
    Clin Cancer Res 11:5319-28. 2005
    ..The role of the mTOR pathway in estrogen-driven proliferation and effects of combining RAD001 and letrozole were examined in vitro in two breast cancer models...
  30. ncbi Coregulator recruitment and histone modifications in transcriptional regulation by the androgen receptor
    Zhigang Kang
    Biomedicum Helsinki, Institute of Biomedicine, University of Helsinki, FI 00014, Finland
    Mol Endocrinol 18:2633-48. 2004
    ....
  31. ncbi Tamoxifen and anastrozole as a sequencing strategy: a randomized controlled trial in postmenopausal patients with endocrine-responsive early breast cancer from the Austrian Breast and Colorectal Cancer Study Group
    Peter C Dubsky
    Medical University of Vienna, Austria
    J Clin Oncol 30:722-8. 2012
    ....
  32. ncbi Suppression of plasma estrogen levels by letrozole and anastrozole is related to body mass index in patients with breast cancer
    Elizabeth J Folkerd
    Royal Marsden Hospital, London, United Kingdom
    J Clin Oncol 30:2977-80. 2012
    ....
  33. ncbi Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes
    A Mari
    National Research Center, Institute of Biomedical Engineering, Corso Stati Uniti 4, 35127 Padova, Italy
    J Clin Endocrinol Metab 90:4888-94. 2005
    ....
  34. pmc Impact of three years of large scale Indoor Residual Spraying (IRS) and Insecticide Treated Nets (ITNs) interventions on insecticide resistance in Anopheles gambiae s.l. in Benin
    Gil Germain Padonou
    Faculté des Sciences et Techniques de l Université d Abomey Calavi, Calavi, Benin
    Parasit Vectors 5:72. 2012
    ..We assessed the impact of this campaign on phenotypic resistance, kdr (knock-down resistance) and ace-1(R) (insensitive acetylcholinesterase) mutations...
  35. ncbi Formation of simple nitriles upon glucosinolate hydrolysis affects direct and indirect defense against the specialist herbivore, Pieris rapae
    Roland Mumm
    Laboratory of Entomology, Wageningen University, 6700 EH, Wageningen, The Netherlands
    J Chem Ecol 34:1311-21. 2008
    ..In contrast, little is known about the biological activities of alternative hydrolysis products such as simple nitriles and epithionitriles that are formed at the expense of isothiocyanates in the presence of epithiospecifier ..
  36. pmc Assessing the general safety and tolerability of vildagliptin: value of pooled analyses from a large safety database versus evaluation of individual studies
    Anja Schweizer
    Novartis Pharma AG, Basel, Switzerland
    Vasc Health Risk Manag 7:49-57. 2011
    ..The aim of this paper is therefore to assess the general safety and tolerability, including incidences of the most common adverse events (AEs), of vildagliptin based on a large pooled database of Phase II and III clinical trials...
  37. ncbi An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    M Ligueros-Saylan
    Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    Diabetes Obes Metab 12:495-509. 2010
    ..To assess the safety of vildagliptin versus all comparators (ACs) with regard to organs, systems or tissues of particular interest in type 2 diabetes (T2DM) and areas of potential concern with dipeptidyl peptidase-IV (DPP-4) inhibitors...
  38. ncbi Clomiphene citrate or letrozole for ovulation induction in women with polycystic ovarian syndrome: a prospective randomized trial
    Ahmed Badawy
    Department of Obstetrics and Gynecology, Mansoura University, Mansoura, Egypt
    Fertil Steril 92:849-52. 2009
    ..To compare the effects of letrozole (5 mg) and clomiphene citrate (100 mg) for ovulation induction in women with polycystic ovary syndrome (PCOS)...
  39. ncbi Metabolic channeling in plants
    Brenda S J Winkel
    Department of Biology and Fralin Biotechnology Center, Virginia Tech, Blacksburg, Virginia 24061 0346, USA
    Annu Rev Plant Biol 55:85-107. 2004
    ..This review also explores current prospects for understanding metabolon structure, assembly, and biological function...
  40. ncbi The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients
    Bogdan Balas
    Diabetes Division, Department of Medicine, University of Texas Health Science Center at San Antonio, 7703 Floyd Drive, MC 7886, San Antonio, Texas 78229, USA
    J Clin Endocrinol Metab 92:1249-55. 2007
    ..However, little is known about the mechanism(s) by which vildagliptin promotes reduction in plasma glucose concentration...
  41. ncbi Safety and efficacy of bosutinib (SKI-606) in chronic phase Philadelphia chromosome-positive chronic myeloid leukemia patients with resistance or intolerance to imatinib
    Jorge E Cortes
    M D Anderson Cancer Center, Houston, TX, USA
    Blood 118:4567-76. 2011
    ..These data suggest bosutinib is effective and tolerable in patients with chronic phase imatinib-resistant or imatinib-intolerant CML. This trial was registered at http://www.clinicaltrials.gov as NCT00261846...
  42. ncbi Androgen receptor or estrogen receptor-beta blockade alters DHEA-, DHT-, and E(2)-induced proliferation and PSA production in human prostate cancer cells
    Julia T Arnold
    Endocrine Section, Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 0933, USA
    Prostate 67:1152-62. 2007
    ..LNCaP and LAPC-4 prostate cancer cells were used to determine whether DHEA-modulated proliferation and prostate specific antigen (PSA) production were mediated via the androgen receptor (AR) and/or ERbeta...
  43. ncbi Cyanogenic glucosides and plant-insect interactions
    Mika Zagrobelny
    Department of Plant Biology and Center of Molecular Plant Physiology PlaCe, Royal Veterinary and Agricultural University, 40 Thorvaldsensvej, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Phytochemistry 65:293-306. 2004
    ..Evolutionary aspects of these unique plant-insect interactions with focus on the enzyme systems involved in synthesis and degradation of cyanogenic glucosides are discussed...
  44. ncbi Comparison of vildagliptin and metformin monotherapy in elderly patients with type 2 diabetes: a 24-week, double-blind, randomized trial
    A Schweizer
    Novartis Pharma AG, Basel, Switzerland
    Diabetes Obes Metab 11:804-12. 2009
    ..The primary objective was to demonstrate non-inferiority of vildagliptin vs. metformin in glycated haemoglobin (HbA1c) reduction...
  45. pmc Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome
    Christine Juliana
    Department of Biochemistry and Molecular Biology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    J Biol Chem 285:9792-802. 2010
    ..Our results thus elucidate the molecular mechanism for the therapeutic anti-inflammatory activity of parthenolide and identify vinyl sulfones as a new class of potential therapeutics that target the NLRP3 inflammasome...
  46. ncbi Pharmacologic inhibition of RAF-->MEK-->ERK signaling elicits pancreatic cancer cell cycle arrest through induced expression of p27Kip1
    Stephan Gysin
    Cancer Research Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco Comprehensive Cancer Center, San Francisco, California 94115, USA
    Cancer Res 65:4870-80. 2005
    ..Moreover, these data suggest that pharmacologic inhibition of the RAF-->MEK-->ERK signaling pathway alone might tend to have a cytostatic, as opposed to a cytotoxic, effect on pancreatic cancer cells...
  47. ncbi The effects of post-surgical administration of goserelin plus anastrozole compared to goserelin alone in patients with severe endometriosis: a prospective randomized trial
    Seyide Soysal
    Department of Obstetrics and Gynecology, Pamukkale University Medical Center, 20100 Denizli, Turkey
    Hum Reprod 19:160-7. 2004
    ....
  48. pmc Early and late effects of the DPP-4 inhibitor vildagliptin in a rat model of post-myocardial infarction heart failure
    Meimei Yin
    University Medical Center Groningen, University of Groningen, Department of Cardiology, Groningen, The Netherlands
    Cardiovasc Diabetol 10:85. 2011
    ..We hypothesized that the DPP-4 inhibitor vildagliptin will increase levels of GLP-1 and may exert protective effects on cardiac function after MI...
  49. ncbi Effect of body mass index on recurrences in tamoxifen and anastrozole treated women: an exploratory analysis from the ATAC trial
    Ivana Sestak
    Cancer Research UK UK, Queen Mary University of London, London, United Kingdom
    J Clin Oncol 28:3411-5. 2010
    ..As aromatase inhibitors work by inhibiting the conversion of androgens to estrogens in adipose tissue, we hypothesized that anastrozole may be more effective in women with a high body mass index (BMI)...
  50. ncbi Effects of vildagliptin on glucose control over 24 weeks in patients with type 2 diabetes inadequately controlled with metformin
    Emanuele Bosi
    Diabetes and Endocrinology Unit, Department of General Medicine, San Raffaele Scientific Institute, Vita Salute San Raffaele University, Milan, Italy
    Diabetes Care 30:890-5. 2007
    ..We sought to evaluate the efficacy and safety of vildagliptin, a new dipeptidyl peptidase-4 inhibitor, added to metformin during 24 weeks of treatment in patients with type 2 diabetes...
  51. ncbi Vildagliptin add-on to metformin produces similar efficacy and reduced hypoglycaemic risk compared with glimepiride, with no weight gain: results from a 2-year study
    D R Matthews
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital and NIHR, Oxford Biomedical Research Centre, UK
    Diabetes Obes Metab 12:780-9. 2010
    ..To show that vildagliptin added to metformin is non-inferior to glimepiride in reducing HbA1c levels from baseline over 2 years...
  52. ncbi The DPP-4 inhibitor vildagliptin increases pancreatic beta cell mass in neonatal rats
    Alokesh Duttaroy
    Novartis Institutes for BioMedical Research, Inc, 100 Technology Square, Cambridge, MA 02139, USA
    Eur J Pharmacol 650:703-7. 2011
    ..This study demonstrates that DPP-4 inhibitors can elicit beneficial effects on beta cell turnover that could help to prevent or retard the progression of type 2 diabetes...
  53. ncbi Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
    Renee E Amori
    Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    JAMA 298:194-206. 2007
    ..Pharmacotherapies that augment the incretin pathway have recently become available, but their role in the management of type 2 diabetes is not well defined...
  54. ncbi Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 11:157-66. 2009
    ..The primary objective was to demonstrate non-inferiority of vildagliptin vs. glimepiride in glycosylated haemoglobin (HbA(1c)) reduction at week 52...
  55. ncbi The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain
    H Y Li
    Department of Occupational and Environmental Health, Institution of Environmental and Health, Major Subject of Environment and Health of Fujian Key Universities, School of Public Health, Fujian Medical University, Fuzhou, China
    Toxicol Ind Health 27:579-90. 2011
    ..Translocation of Nrf2 may be a response to DM-dependent induction of free radicals and DM may act as a mammalian neurotoxin by initiating oxidative stress...
  56. doi Sustained efficacy and reduced hypoglycemia during one year of treatment with vildagliptin added to insulin in patients with type 2 diabetes mellitus
    V Fonseca
    Endocrinology Department, Tulane University Health Sciences Center, New Orleans, Louisiana 70112, USA
    Horm Metab Res 40:427-30. 2008
  57. ncbi Single nucleotide polymorphisms of CYP19A1 predict clinical outcomes and adverse events associated with letrozole in patients with metastatic breast cancer
    In Hae Park
    Center for Breast Cancer, National Cancer Center, 323 Ilsan ro, Ilsandong gu, Goyang si, Gyeonggi do 410 769, Korea
    Cancer Chemother Pharmacol 68:1263-71. 2011
    ..We evaluated the efficacy of the aromatase inhibitor letrozole in patients with metastatic breast cancer (MBC) as related to DNA polymorphisms of CYP19A1...
  58. ncbi Clinical evidence and mechanistic basis for vildagliptin's action when added to metformin
    B Ahren
    Department of Clinical Sciences, Lund University, Lund, Sweden
    Diabetes Obes Metab 13:193-203. 2011
    ..Therefore, vildagliptin offers a clinically important outcome when added to metformin with a twice daily dose regimen, taking advantage of its tight binding and slow dissociation characteristics that lead to a sustained overnight effect...
  59. ncbi Effects of vildagliptin on glucose control in patients with type 2 diabetes inadequately controlled with a sulphonylurea
    A J Garber
    Baylor College of Medicine, Houston, TX, USA
    Diabetes Obes Metab 10:1047-56. 2008
    ..To compare the efficacy and tolerability of vildagliptin vs. placebo in patients with type 2 diabetes mellitus (T2DM) who are inadequately controlled [haemoglobin A(1c) (HbA(1c)) 7.5 to 11%] with prior sulphonylurea (SU) monotherapy...
  60. ncbi The Patient's Anastrozole Compliance to Therapy (PACT) Program: a randomized, in-practice study on the impact of a standardized information program on persistence and compliance to adjuvant endocrine therapy in postmenopausal women with early breast cance
    P Hadji
    Department of Gynecology, Endocrinology and Oncology, Phillips University of Marburg, Marburg, Germany
    Ann Oncol 24:1505-12. 2013
    ..Compliance and persistence are often overlooked in adjuvant breast cancer treatment...
  61. ncbi IL-33 is induced by amyloid-β stimulation and regulates inflammatory cytokine production in retinal pigment epithelium cells
    Xiao Cui Liu
    Department of Ophthalmology, Chinese PLA People s Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China
    Inflammation 35:776-84. 2012
    ..Greater understanding of the inflammatory effect of IL-33 and its role in RPE cells should aid the development of future clinical therapeutics and enable novel pharmacological approaches towards the prevention of AMD...
  62. ncbi Effects of PKF275-055, a dipeptidyl peptidase-4 inhibitor, on the development of atherosclerotic lesions in apolipoprotein E-null mice
    Michishige Terasaki
    Department of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo 142 8666, Japan
    Metabolism 61:974-7. 2012
    ..Foam cell formation was suppressed by 40% in the exudate peritoneal macrophages obtained from the PKF-treated mice. The DPP-4 inhibitor prevents the development of atherosclerotic lesions by suppressing macrophage foam cell formation...
  63. ncbi Identification of mutations associated with pyrethroid resistance in the voltage-gated sodium channel of the tomato leaf miner (Tuta absoluta)
    Khalid Haddi
    Dipartimento di Gestione dei Sistemi Agroalimentari e Ambientali, Sezione Entomologia Agraria, Catania, Italy
    Insect Biochem Mol Biol 42:506-13. 2012
    ....
  64. pmc Activation of remote meta-C-H bonds assisted by an end-on template
    Dasheng Leow
    Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 486:518-22. 2012
    ..In addition, this template overrides the intrinsic electronic and steric biases as well as ortho-directing effects with two broadly useful classes of arene substrates (toluene derivatives and hydrocinnamic acids)...
  65. pmc Impact of premenopausal status at breast cancer diagnosis in women entered on the placebo-controlled NCIC CTG MA17 trial of extended adjuvant letrozole
    P E Goss
    Cancer Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Oncol 24:355-61. 2013
    ..MA17 showed improved outcomes in postmenopausal women given extended letrozole (LET) after completing 5 years of adjuvant tamoxifen...
  66. ncbi Novel aspects of therapy with the dual Src and Abl kinase inhibitor bosutinib in chronic myeloid leukemia
    Gunhild Keller-V Amsberg
    Klinik für Hämatologie und Onkologie mit der Sektion Pneumologie, Onkologisches Zentrum, Universitäts Klinikum Hamburg Eppendorf, Hamburg, Germany
    Expert Rev Anticancer Ther 12:1121-7. 2012
    ..This may be causative for its favorable hematologic toxicity profile. In this review, the authors give an overview on the mechanism of action and currently available preclinical and clinical data for bosutinib in CML...
  67. ncbi Intraspecific competition delays recovery of population structure
    Matthias Liess
    UFZ Helmholtz Centre for Environmental Research, Department of System Ecotoxicology, Permoserstrasse 15, D 04318 Leipzig, Germany
    Aquat Toxicol 97:15-22. 2010
    ..We conclude that competition needs to be considered in order to understand and predict recovery of size structure...
  68. ncbi Combined androgen blockade for prostate cancer: review of efficacy, safety and cost-effectiveness
    Hideyuki Akaza
    Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:51-6. 2011
    ....
  69. pmc Evidence to support the use of vildagliptin monotherapy in the treatment of type 2 diabetes mellitus
    Sylvie Dejager
    Novartis Pharma SAS, Rueil Malmaison, France
    Vasc Health Risk Manag 8:339-48. 2012
    ....
  70. pmc Efficacy of vildagliptin in combination with insulin in patients with type 2 diabetes and severe renal impairment
    Valentina Lukashevich
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936 1080, USA
    Vasc Health Risk Manag 9:21-8. 2013
    ..73 m(2)) and longstanding type 2 diabetes not adequately controlled with insulin therapy, which is a difficult-to-treat population, with limited therapeutic options and a high susceptibility to hypoglycemia...
  71. ncbi Efficacy and safety comparison between the DPP-4 inhibitor vildagliptin and the sulfonylurea gliclazide after two years of monotherapy in drug-naïve patients with type 2 diabetes
    J E Foley
    Clinical Research and Development, Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA
    Horm Metab Res 41:905-9. 2009
    ....
  72. pmc ER-alpha36, a variant of ER-alpha, promotes tamoxifen agonist action in endometrial cancer cells via the MAPK/ERK and PI3K/Akt pathways
    Sheng Li Lin
    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences and Graduate School, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 5:e9013. 2010
    ..ER-alpha36 lacks intrinsic transcription activity and mainly mediates nongenomic estrogen signaling. Here, we studied the role of nongenomic estrogen signaling pathways mediated by ER-alpha36 in tamoxifen resistance and agonist action...
  73. ncbi BAY 11-7082, a nuclear factor-κB inhibitor, reduces inflammation and apoptosis in a rat cardiac ischemia-reperfusion injury model
    Yong Sook Kim
    Heart Research Center, Chonnam National University Hospital, Gwangju, South Korea
    Int Heart J 51:348-53. 2010
    ..These data demonstrate that a currently available and well-tolerated inhibitor of NF-κB can decrease the risk of myocardial injury associated with I/R...
  74. ncbi Environmental context determines community sensitivity of freshwater zooplankton to a pesticide
    Nathalie C Stampfli
    Department of System Ecotoxicology, Helmholtz Centre for Environmental Research UFZ, Permoserstraße 15, 04318 Leipzig, Germany
    Aquat Toxicol 104:116-24. 2011
    ..These findings indicate that environmental context is more important for ecotoxicological evaluation than assumed previously...
  75. pmc Predictors of Plasmodium falciparum malaria incidence in Chano Mille, South Ethiopia: a longitudinal study
    Eskindir Loha
    School of Public and Environmental Health, Hawassa University, Ethiopia
    Am J Trop Med Hyg 87:450-9. 2012
    ..Although ITNs prevented falciparum malaria for the users, we did not find that free mass ITNs distribution reduced falciparum malaria on a village level...
  76. ncbi Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum
    Xing Ding Zhang
    Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Medicine, Suzhou, China
    J Neurosci Res 87:3600-10. 2009
    ..Bcl-2 thus plays important roles in mitochondria dysfunction-induced apoptotic death of stritatal neurons by modulating both autophagic and apoptotic processes...
  77. ncbi Suppression of NF-κB and NF-κB regulated oxidative stress and neuroinflammation by BAY 11-7082 (IκB phosphorylation inhibitor) in experimental diabetic neuropathy
    Ashutosh Kumar
    Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Sec 67, S A S Nagar, Mohali, Punjab 160062, India
    Biochimie 94:1158-65. 2012
    ....
  78. ncbi Incretin therapies in the management of elderly patients with type 2 diabetes mellitus
    Isabelle Bourdel-Marchasson
    Pôle de Gérontologie Clinique, Centre Henri Choussat, Hopital Xavier Arnozan, Bordeaux, France
    Hosp Pract (1995) 39:7-21. 2011
    ..Therefore, available data from elderly subgroups of individual studies were also reviewed when available, as well as pooled analyses by age subgroups across clinical programs conducted with incretin therapies...
  79. pmc Efficacy and safety of vildagliptin and voglibose in Japanese patients with type 2 diabetes: a 12-week, randomized, double-blind, active-controlled study
    Y Iwamoto
    Diabetes Center, Tokyo Women s Medical University, School of Medicine, Tokyo, Japan
    Diabetes Obes Metab 12:700-8. 2010
    ..To confirm the efficacy of vildagliptin in patients with type 2 diabetes (T2D) by testing the hypothesis that glycosylated haemoglobin (HbA1c) reduction with vildagliptin is superior to that with voglibose after 12 weeks of treatment...
  80. ncbi Efficacy and safety of rilpivirine (TMC278) versus efavirenz at 48 weeks in treatment-naive HIV-1-infected patients: pooled results from the phase 3 double-blind randomized ECHO and THRIVE Trials
    Calvin J Cohen
    Community Research Initiative of New England, Boston, MA, USA
    J Acquir Immune Defic Syndr 60:33-42. 2012
    ..Pooled analysis of phase 3, double-blind, double-dummy ECHO and THRIVE trials comparing rilpivirine (TMC278) and efavirenz...
  81. pmc Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial
    J E Foley
    Novartis Pharmaceutical Cooperation, Clinical Research and Development, One Health Plaza, East Hanover, NJ 07936, USA
    Diabetologia 54:1985-91. 2011
    ..Here, we assessed the insulin secretory capacity in drug-naive patients with type 2 diabetes after a 52 week treatment period with vildagliptin or placebo, and again after a 12 week washout period...
  82. pmc Use of letrozole in assisted reproduction: a systematic review and meta-analysis
    Antonio Requena
    IVI Madrid, Santiago de Compostela 88, E 28035 Madrid, Spain
    Hum Reprod Update 14:571-82. 2008
    ..AIs induce ovulation by inhibiting estrogen production; the consequent hypoestrogenic state increases GnRH release and pituitary follicle-stimulating hormone (FSH) synthesis...
  83. ncbi Risk factors for joint symptoms in patients enrolled in the ATAC trial: a retrospective, exploratory analysis
    Ivana Sestak
    Cancer Research UK, Centre for Epidemiology, Mathematics, and Statistics, Wolfson Institute of Preventive Medicine, London, UK
    Lancet Oncol 9:866-72. 2008
    ..The aim of this study was to assess the relative importance of different risk factors for treatment-emergent joint symptoms in patients assigned to anastrozole or tamoxifen as adjuvant treatment for postmenopausal breast cancer...
  84. ncbi Management of poor responders: can outcomes be improved with a novel gonadotropin-releasing hormone antagonist/letrozole protocol?
    William B Schoolcraft
    Colorado Center for Reproductive Medicine, Englewood, Colorado, USA
    Fertil Steril 89:151-6. 2008
    ..To compare the efficacy of a microdose GnRH agonist flare (ML) with a GnRH antagonist/letrozole (AL) protocol before IVF-ET in poor responders...
  85. ncbi Role of vildagliptin in managing type 2 diabetes mellitus in the elderly
    S Halimi
    University Hospital of Grenoble, Grenoble, France
    Curr Med Res Opin 26:1647-56. 2010
    ..The objective of this review is to provide an overview of the challenges in managing T2DM in the elderly, with an emphasis on prevention of hypoglycaemia and the role of the DPP-4 inhibitor vildagliptin in this patient population...
  86. ncbi Effect of dipeptidyl peptidase-IV (DPP-IV) inhibitor (Vildagliptin) on peripheral nerves in streptozotocin-induced diabetic rats
    Heung Yong Jin
    Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Arch Med Res 40:536-44. 2009
    ..The aim of this study was to investigate the GLP-1 pathway effect on peripheral nerves using a DPP-IV inhibitor in streptozotocin (STZ)-induced diabetic rats...
  87. ncbi Letrozole compared with tamoxifen for elderly patients with endocrine-responsive early breast cancer: the BIG 1-98 trial
    Diana Crivellari
    IBCSG Coordinating Center, Effingerstrasse 40, CH 3008 Bern, Switzerland
    J Clin Oncol 26:1972-9. 2008
    ..To explore potential differences in efficacy, treatment completion, and adverse events (AEs) in elderly women receiving adjuvant tamoxifen or letrozole for five years in the Breast International Group (BIG) 1-98 trial...
  88. ncbi Letrozole and norethisterone acetate in colorectal endometriosis
    Simone Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Genoa, Italy
    Eur J Obstet Gynecol Reprod Biol 150:199-202. 2010
    ..This study evaluates the efficacy of aromatase inhibitors and norethisterone acetate in treating pain and gastrointestinal symptoms caused by bowel endometriosis...
  89. ncbi Aromatase inhibitors for female infertility: a systematic review of the literature
    Nikolaos P Polyzos
    PACMeR Panhellenic Association for Continual Medical Research, Section of Obstetrics and Gynaecology and Public Health, Athens 10438, Greece
    Reprod Biomed Online 19:456-71. 2009
    ..If solid data from future large adequately powered randomized trials support current evidence regarding efficacy and safety, AI might offer a new treatment choice for infertile women...
  90. ncbi Pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate in unexplained infertility
    Ahmed Badawy
    Department of Obstetrics and Gynecology, Mansoura University, Egypt
    Acta Obstet Gynecol Scand 88:187-91. 2009
    ..To evaluate the pregnancy outcome after ovulation induction with aromatase inhibitors or clomiphene citrate (CC)...
  91. ncbi Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin
    G Bolli
    Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Obes Metab 11:589-95. 2009
    ..To compare the tolerability and efficacy of vildagliptin to pioglitazone as add-on therapy in patients with type 2 diabetes inadequately controlled with metformin monotherapy over 1-year duration...
  92. ncbi Vildagliptin plus metformin combination therapy provides superior glycaemic control to individual monotherapy in treatment-naive patients with type 2 diabetes mellitus
    E Bosi
    Department of Medicine, Diabetes and Endocrinology Unit, San Raffaele Scientific Institute and Vita Salute San Raffaele University, Milan, Italy
    Diabetes Obes Metab 11:506-15. 2009
    ..To compare the efficacy and safety of vildagliptin and metformin initial combination therapy with individual monotherapies in treatment-naive patients with type 2 diabetes mellitus (T2DM)...
  93. ncbi Letrozole combined with norethisterone acetate compared with norethisterone acetate alone in the treatment of pain symptoms caused by endometriosis
    S Ferrero
    Department of Obstetrics and Gynaecology, San Martino Hospital and University of Genoa, Largo R Benzi 1 16132, Genoa, Italy
    Hum Reprod 24:3033-41. 2009
    ..We compared the efficacy and tolerability of the aromatase inhibitor letrozole combined with norethisterone acetate versus norethisterone acetate alone in treating pain symptoms...
  94. ncbi Efficacy and tolerability of vildagliptin in patients with type 2 diabetes inadequately controlled with metformin monotherapy
    M Goodman
    Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936 1080, USA
    Horm Metab Res 41:368-73. 2009
    ....
  95. ncbi Selective inhibition of MEK1/2 reveals a differential requirement for ERK1/2 signalling in the regulation of HIF-1 in response to hypoxia and IGF-1
    K M Sutton
    Cell Growth Regulation and Angiogenesis Team, Cancer Research UK Centre for Cancer Therapeutics, The Institute of Cancer Research, Sutton, Surrey, UK
    Oncogene 26:3920-9. 2007
    ....
  96. ncbi Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
    Karin Simonin
    Groupe Régional d Etudes sur le Cancer, Centre de Lutte contre le Cancer Francois Baclesse, Caen, France
    Mol Cancer Ther 8:3162-70. 2009
    ..BH3-mimetic compounds represent promising tools for this purpose either on their own (direct or indirect pan-inhibitors) or in combination with new drugs aiming to inactivate Mcl-1...
  97. ncbi Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis
    Hanshi Sun
    Department of Internal Medicine, Division of Hematology Oncology, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    Blood 117:3151-62. 2011
    ..This approach may be a therapeutic option for kinase inhibitor-resistant CML patients...
  98. ncbi Vildagliptin: a review of its use in type 2 diabetes mellitus
    Gillian M Keating
    Adis, a Wolters Kluwer Business, Auckland, New Zealand
    Drugs 70:2089-112. 2010
    ..In conclusion, vildagliptin is an important option for use in combination with metformin, a sulfonylurea or a thiazolidinedione in patients with type 2 diabetes who require combination therapy...
  99. ncbi Vildagliptin blocks vascular injury in thoracic aorta of diabetic rats by suppressing advanced glycation end product-receptor axis
    Takanori Matsui
    Department of Pathophysiology and Therapeutics of Diabetic Vascular Complications, Kurume University School of Medicine, Kurume 830 0011, Fukuoka, Japan
    Pharmacol Res 63:383-8. 2011
    ..Our present data suggest that vildagliptin could play a protective role against vascular injury in diabetes partly by attenuating the deleterious effects of AGEs-RAGE-oxidative stress axis...
  100. pmc The genetic basis of constitutive and herbivore-induced ESP-independent nitrile formation in Arabidopsis
    Meike Burow
    Institut fur Pharmazeutische Biologie, Technische Universitat Braunschweig, 38106 Braunschweig, Germany
    Plant Physiol 149:561-74. 2009
    ..In the presence of specifier proteins, alternative products, namely epithionitriles, simple nitriles, and thiocyanates with different biological activities, are formed at the expense of isothiocyanates...
  101. ncbi The androgen receptor pathway is by-passed in prostate cancer cells generated after prolonged treatment with bicalutamide
    Alfred Hobisch
    Department of Urology, General Hospital Feldkirch, Feldkirch, Austria
    Prostate 66:413-20. 2006
    ..However, little attention has been paid to the androgen receptor-signaling pathway in the development of therapy resistance in patients who receive chronic treatment with a non-steroidal anti-androgen...

Research Grants62

  1. DESIGN AND SYNTHESIS OF CYSTEINE PROTEINASE INHIBITORS
    DANIEL RICH; Fiscal Year: 1992
    ..include: Determine the structure-activity relationships for new peptidyl semicarbazones, aldehydes, and nitriles for inhibition of the following cysteine proteinases: papain; cathepsin B, H, and L; the cysteine proteinase for ..
  2. ASYMMETRIC SYNTHESIS OF BIOACTIVE PRIMARY AMINES
    FRANKLIN DAVIS; Fiscal Year: 2006
    ..Addition of laterally lithiated nitriles and amides to sulfinimines provide 3,4-dihydroisoquinolines and 3,5-dihydro-1 (2H)-isoquinolones, building blocks ..
  3. NOVEL ROUTES TO PHYSIOLOGICALLY ACTIVE COMPOUNDS
    K Vollhardt; Fiscal Year: 1991
    ..are to use highly reactive forms of cyclopentadienylcobalt to effect low temperature cyclizations of alkynes and nitriles to give specifically substituted arenes and heteroarenes, including aromatic steroids and ergot alkaloids...
  4. ROLE OF VEHICLES IN TOXICITY OF NITRILES
    MOHAMMED FAROOQUI; Fiscal Year: 1990
    ..investigation is to elucidate the relationship of vehicle to toxicity and metabolic fate of selected unsaturated nitriles. The selection of nitriles stems from the fact that nitriles are very important monomers used in the polymer, ..
  5. SYNTHESIS OF AMINO ACID-DERIVED NATURAL PRODUCTS
    David Evans; Fiscal Year: 2000
    ..to the asymmetric synthesis of hydroxy-alpha-amino acids and alpha,beta-diamino acids as well as alpha-amino nitriles. In closely related studies, we will utilize chiral metal catalysts to promote the enol insertion of metal ..
  6. A Biocatalytic Route to Nitrile Reduction
    Dirk Iwata Reuyl; Fiscal Year: 2006
    ..Biocatalysis has become an important option for catalyzing the conversion of nitriles to acids and amides due to the existence of the enzymes nitrilase and nitrile hydratase, respectively...
  7. STRUCTURE-FUNCTION STUDIES ON NITRILE HYDRATASE MODELS
    PRADIP MASCHARAK; Fiscal Year: 2003
    ..techniques and in one case by crystallography, the role of the M(III) center in the catalytic conversion of nitriles to amides has not been elucidated...
  8. METALLACYCLOBUTENES, SYNTHESIS AND REACTIVITY
    KENNETH DOXSEE; Fiscal Year: 1992
    ..Metallacyclobutenes react with unsaturated organic substrates such as carbonyl compounds, nitriles, and sulfoxides, yielding organometallic complexes which may be transformed into a wide variety of important ..
  9. ASYMMETRIC CATALYSIS OF STRECKER AMINO ACID SYNTHESIS
    Mark Lipton; Fiscal Year: 1999
    ..B. Exploration of alternate methods for the hydrolysis of alpha-amino nitriles to alpha-amino acids. C. Further exploring the scope of substrates allowed. D...
  10. Estrogen regulation of uterine microRNAs: Novel factors in MMP-9 regulation
    Warren Nothnick; Fiscal Year: 2008
    ..Enhancing our understanding on the regulation of MMP-9 expression may lead to the establishment of novel approaches to counteract mis-expression of this protease and the diseases associated with it. [unreadable] [unreadable] [unreadable]..
  11. The Role of TIMP-1 in Uterine Physiology
    Warren Nothnick; Fiscal Year: 2005
    ..These studies will broaden our understanding on the role of TIMP-1 in uterine physiology and may help to develop new strategies to treat uterine disorders such as infertility, endometriosis and uterine cancer. ..
  12. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..The relationship of the fundamental independent variables to the kinetic parameters of permeation and to the Corrositex rating as the index of irritation will be determined and compared. ..
  13. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  14. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  15. CANCER GENETICS NETWORK
    Claudine Isaacs; Fiscal Year: 2006
    ....
  16. Regulation of the von Hippel-Lindau Protein
    Paul Corn; Fiscal Year: 2007
    ..abstract_text> ..
  17. ACYCLIC STEREOCONTROL IN RADICAL REACTIONS
    MUKUND SIBI; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  18. DNA and Phytochemical Fingerprinting of Actaea Species
    Edward Kennelly; Fiscal Year: 2007
    ..Our long-range goals are to improve the quality of black cohosh dietary supplements and understand the variation in Actaea species. ..
  19. Prognosis in BRCA1 Associated Breast Cancer
    Pamela Goodwin; Fiscal Year: 2007
    ..Because this research is nested within the CFRBCS, the objectives can be addressed in a timely and cost effective manner. ..
  20. Ensemble Disruption of the GnRH-LH-Testosterone Axis
    Johannes Veldhuis; Fiscal Year: 2007
    ..Expected corollary outcomes are enhanced diagnosis, assessment and management of more subtle pathophysiology of the male gonadal axis in puberty and adulthood. ..
  21. Purification of Oligonucleotides and Nucleoside Triphosphates
    William Pearson; Fiscal Year: 2007
    ..The proposed work seeks to further develop an entirely new method for oligonucleotide purification, thus streamlining the development and production of these crucial substances. [unreadable] [unreadable] [unreadable]..
  22. Mechanistic bases for age-related androgen deficiency
    Johannes Veldhuis; Fiscal Year: 2007
    ..Knowing why testosterone falls should help foster new and safer ways to prevent the problem. [unreadable] [unreadable] [unreadable]..
  23. Rhesus Embryonic Stem Cell-Derived Serotonin Neurons
    CYNTHIA BETHEA; Fiscal Year: 2007
    ..The knowledge obtained from this work will lead to novel treatments for psychoneuropathologies. [unreadable] [unreadable]..
  24. Discovery of a Selective Agent that Activates PON1 Enzymatic Activity
    John Scott; Fiscal Year: 2007
    ..Atherosclerosis is the number one cause of mortality in Western societies. This research proposal focuses on generating research tools to evaluate a novel therapeutic strategy to prevent atherosclerosis. ..
  25. OVARIAN STEROID REGULATION OF SEROTONIN IN PRIMATES
    CYNTHIA LOUISE BETHEA; Fiscal Year: 2010
    ..Altogether, we will show that ovarian steroids support serotonin neuron survival and we will provide pivotal underlying genomic mechanisms. ..
  26. Genetic effectors of TGF-beta induced growth and arrest.
    BEN H PARK; Fiscal Year: 2010
    ..Isolated genes will be verified and validated by restoration of the putative gene and correlated with immunohistochemical studies using tissue microarrays. ..
  27. PROGESTERONE THERAPY FOR WOMEN WITH EPILEPSY
    Andrew Herzog; Fiscal Year: 2008
    ..30 x .35) 100,000 women with catamenial epilepsy and perhaps many more women with no a priori demonstrated hormonal sensitivity to seizure occurrence. ..
  28. First International Inflammatory Breast Cancer Conference
    Massimo Cristofanilli; Fiscal Year: 2008
    ..For project details please see "Conference Plan". [unreadable] [unreadable] [unreadable]..
  29. RAAS, Inflammation & Post-Operative Atrial Fibrillation
    Nancy Brown; Fiscal Year: 2009
    ..abstract_text> ..
  30. Multidisciplinary Program in Female and Male Reproduction
    EUGENE ALBRECHT; Fiscal Year: 2008
    ..The discoveries obtained in the baboon primate model are expected to translate to the human to advance knowledge of human reproductive biology. [unreadable] [unreadable]..
  31. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  32. Targets for short-course TB therapy
    Christopher Sassetti; Fiscal Year: 2008
    ..Short-course therapy could impact the worldwide tuberculosis epidemic both by making treatment more widely available and by reducing the rate at which drug-resistant strains emerge. [unreadable] [unreadable] [unreadable]..
  33. Novel Active Repressor Model of Human LDL-Receptor Regulation
    Johannes Veldhuis; Fiscal Year: 2008
    ..This would represent a new treatment approach for patients with atherosclerotic disease. [unreadable] [unreadable] [unreadable] [unreadable]..
  34. Quantitative methods for genetic linkage heterogeneity
    Daniel Schaid; Fiscal Year: 2008
    ..Aim 3. User-friendly software: User-friendly software that implements the proposed methods, including well-documented procedures and examples of their usage, will be provided free to the scientific community. ..
  35. Strengthening Botanical CAM Research: A Collaboration between CUNY and Columbia
    Edward Kennelly; Fiscal Year: 2007
    ..We anticipate that within a year after the end of the project period, several R21 or R01 botanically-related CAM applications will be submitted to NIH. ..
  36. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  38. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  39. Purification of Optically Labeled Oligonucleotides
    William Pearson; Fiscal Year: 2004
    ..Initial work will focus on oligonucleotide probe purification. ..
  40. ENSEMBLE MODEL OF STRESS ACTH-ADRENAL AXIS
    Johannes Veldhuis; Fiscal Year: 2005
    ....
  41. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  42. Effect of Continuous vs. Sequential Oral Contraception
    RICHARD LEGRO; Fiscal Year: 2004
    ..Therefore, the risks and benefits of a CCOCP regimen are an important women's health issue that warrant investigation. ..
  43. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  44. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  45. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..
  46. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2003
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  47. Endothelial Nitric Oxide Synthase & Portal Hypertension
    Vijay Shah; Fiscal Year: 2002
    ..abstract_text> ..
  48. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2001
    ....
  49. THE AGING GH AXIS IN POSTMENOPAUSAL WOMEN
    Johannes Veldhuis; Fiscal Year: 2005
    ..An enhanced knowledge base should aid ultimately in formulating more innovative preventive and interventional strategies to limit hyposomatotropism in older and/or estrogen-deficient humans. ..
  50. INSULIN RESISTANCE IN PCOS--SEQUELAE AND TREATMENT
    RICHARD LEGRO; Fiscal Year: 2005
    ..Improving insulin action through diet and exercise, with and without weight loss, will result in lowered circulating insulin levels, lowered androgens and increased ovulatory frequency rate in PCOS women. ..
  51. Vanderbilt Mentored Clinical Research Scholar Program
    Nancy Brown; Fiscal Year: 2006
    ..The VCRS program will train successful new clinical investigators who will serve as leaders role in the post-genomic era. [unreadable] [unreadable] [unreadable]..
  52. Effects of Antioxidants on Human Macular Pigments
    Kyung Jin Yeum; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. ACTIONS OF ESTROGEN IN MATURING GRAAFIAN FOLLICLES
    Johannes Veldhuis; Fiscal Year: 2005
    ..Understanding such fundamental interactions is important to the rational design of alternative strategies to interrupt normal and rescue impaired steroidogenesis in the maturing Graafian follicle and corpus luteum. ..
  54. Bis-phenol A: Signaling and Mitogenesis in the Prostate
    Karen Knudsen; Fiscal Year: 2006
    ..abstract_text> ..
  55. Radioimmunotherapy: An Anti-Neoplastic Strategy
    Andres Forero; Fiscal Year: 2006
    ..The follow-up trial will be a phase II study to determine the efficacy of 131I-HuCC49ACH2 in resistant/refractory EOC patients. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  56. Analysis of 5'UTR-Mediated Regulation of p53 Expression
    Philip Lazarus; Fiscal Year: 2006
    ..abstract_text> ..
  57. Southeastern Michigan Parkinson's Disease Program
    Peter LeWitt; Fiscal Year: 2006
    ..This application also discusses concepts for three pharmacological agents that could be investigated in pilot studies and, if promising, in multicenter clinical trials for assessing neuroprotection. ..
  58. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  59. Inhibition of TNF in Patients with Alcoholic Hepatitis
    Vijay Shah; Fiscal Year: 2005
    ..abstract_text> ..
  60. NEW DEVELOPMENTS IN ORGANOCOPPER CHEMISTRY
    R Dieter; Fiscal Year: 2004
    ..The proposed synthetic routes to pyrrolidine aza sugars will develop the potential synthetic power of alpha-aminoalkylcuprate chemistry. ..
  61. QUANTITATIVE ASSOCIATION METHODS FOR GENE MAPPING
    Daniel Schaid; Fiscal Year: 2001
    ..The advantages of this proposed research, over those currently used to identify and characterize genes of complex diseases, are that it will offer a more powerful and flexible method to find these types of genes. ..