nitrates

Summary

Summary: Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.

Top Publications

  1. ncbi Uptake, allocation and signaling of nitrate
    Ya Yun Wang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Trends Plant Sci 17:458-67. 2012
  2. ncbi A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    K M Miranda
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, Maryland 20892, USA
    Nitric Oxide 5:62-71. 2001
  3. ncbi An Arabidopsis MADS box gene that controls nutrient-induced changes in root architecture
    H Zhang
    Biochemistry and Physiology Department, IACR Rothamsted, Harpenden, Herts AL5 2JQ, UK
    Science 279:407-9. 1998
  4. ncbi CHL1 functions as a nitrate sensor in plants
    Cheng Hsun Ho
    Molecular Cell Biology, Institute of Molecular Biology, Academia Sinica, and Taipei, Taiwan
    Cell 138:1184-94. 2009
  5. pmc Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism
    Rongchen Wang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla 92093 0116, USA
    Plant Physiol 132:556-67. 2003
  6. ncbi Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants
    Gabriel Krouk
    Biochimie et Physiologie Moleculaire des Plantes, UMR 5004 CNRS INRA SupAgro M UM2, Institut de Biologie Integrative des Plantes, Place Viala, 34060 Montpellier Cedex 1, France
    Dev Cell 18:927-37. 2010
  7. pmc Cell-specific nitrogen responses mediate developmental plasticity
    Miriam L Gifford
    Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 105:803-8. 2008
  8. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
  9. pmc Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation
    Kun Hsiang Liu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    EMBO J 22:1005-13. 2003
  10. pmc Dichotomy in the NRT gene families of dicots and grass species
    Darren Plett
    Australian Centre for Plant Functional Genomics, Waite Research Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 5:e15289. 2010

Detail Information

Publications312 found, 100 shown here

  1. ncbi Uptake, allocation and signaling of nitrate
    Ya Yun Wang
    Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan
    Trends Plant Sci 17:458-67. 2012
    ..Interestingly, several of these transporters also play versatile roles in nitrate sensing, plant development, pathogen defense, and/or stress response...
  2. ncbi A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite
    K M Miranda
    Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Building 10, Room B3 B69, Bethesda, Maryland 20892, USA
    Nitric Oxide 5:62-71. 2001
    ..This report introduces a new, convenient assay for the stable oxidation products of nitrogen oxide chemistry in biological samples...
  3. ncbi An Arabidopsis MADS box gene that controls nutrient-induced changes in root architecture
    H Zhang
    Biochemistry and Physiology Department, IACR Rothamsted, Harpenden, Herts AL5 2JQ, UK
    Science 279:407-9. 1998
    ....
  4. ncbi CHL1 functions as a nitrate sensor in plants
    Cheng Hsun Ho
    Molecular Cell Biology, Institute of Molecular Biology, Academia Sinica, and Taipei, Taiwan
    Cell 138:1184-94. 2009
    ..For a video summary of this article, see the PaperFlick file with the Supplemental Data available online...
  5. pmc Microarray analysis of the nitrate response in Arabidopsis roots and shoots reveals over 1,000 rapidly responding genes and new linkages to glucose, trehalose-6-phosphate, iron, and sulfate metabolism
    Rongchen Wang
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla 92093 0116, USA
    Plant Physiol 132:556-67. 2003
    ..These results show that the effect of nitrate on gene expression is substantial (affecting almost 10% of the genes with detectable mRNA levels) yet selective and affects many genes involved in carbon and nutrient metabolism...
  6. ncbi Nitrate-regulated auxin transport by NRT1.1 defines a mechanism for nutrient sensing in plants
    Gabriel Krouk
    Biochimie et Physiologie Moleculaire des Plantes, UMR 5004 CNRS INRA SupAgro M UM2, Institut de Biologie Integrative des Plantes, Place Viala, 34060 Montpellier Cedex 1, France
    Dev Cell 18:927-37. 2010
    ..1 represses lateral root growth at low nitrate availability by promoting basipetal auxin transport out of these roots. This defines a mechanism connecting nutrient and hormone signaling during organ development...
  7. pmc Cell-specific nitrogen responses mediate developmental plasticity
    Miriam L Gifford
    Center for Genomics and Systems Biology, New York University, 100 Washington Square East, New York, NY 10003, USA
    Proc Natl Acad Sci U S A 105:803-8. 2008
    ..Thus, the results make an important advance in our understanding of how multicellular organisms cope with environmental change at the cell level...
  8. pmc Nitric oxide, oxidants, and protein tyrosine nitration
    Rafael Radi
    Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la Republica, Avda General Flores 2125, 11800 Montevideo, Uruguay
    Proc Natl Acad Sci U S A 101:4003-8. 2004
    ....
  9. pmc Switching between the two action modes of the dual-affinity nitrate transporter CHL1 by phosphorylation
    Kun Hsiang Liu
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    EMBO J 22:1005-13. 2003
    ..These results demonstrate yet another regulatory role of phosphorylation in plant physiology...
  10. pmc Dichotomy in the NRT gene families of dicots and grass species
    Darren Plett
    Australian Centre for Plant Functional Genomics, Waite Research Institute, University of Adelaide, Adelaide, South Australia, Australia
    PLoS ONE 5:e15289. 2010
    ..2 gene which may be a fusion of the NRT3.1 and NRT3.2 genes present in all other species examined here. This work provides a framework for future analysis of NO(3)(-) transporters and NO(3)(-) transport in grass crop species...
  11. ncbi Nitrate transport capacity of the Arabidopsis thaliana NRT2 family members and their interactions with AtNAR2.1
    Zorica Kotur
    University of British Columbia, Vancouver, BC, Canada
    New Phytol 194:724-31. 2012
    ..1. • Co-injection into Xenopus oocytes of cRNA of all NRT2 genes together with cRNA of AtNAR2.1 resulted in statistically significant increases of uptake over and above that resulting from single cRNA injections...
  12. ncbi Nitrate and phosphate availability and distribution have different effects on root system architecture of Arabidopsis
    Birgit I Linkohr
    Department of Biology, University of York, UK
    Plant J 29:751-60. 2002
    ..The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response...
  13. ncbi Disruption of the nitrate transporter genes AtNRT2.1 and AtNRT2.2 restricts growth at low external nitrate concentration
    Mathilde Orsel
    Unité de la Nutrition Azotée des Plantes, INRA, Route de St Cyr, 78026, Versailles Cedex, France
    Planta 219:714-21. 2004
    ..4 and AtNRT2.5 genes were over-expressed in the mutant growing in reduced N-conditions, without any compensation by root nitrate influx. These results are discussed in the context of the putative role of the different NRT2 genes...
  14. pmc Transcriptome analysis of nitrate assimilation in Aspergillus nidulans reveals connections to nitric oxide metabolism
    Thorsten Schinko
    Fungal Genetics and Genomics Unit, Department of Applied Genetics and Cell Biology, Austrian Institute of Technology and BOKU University Vienna, Muthgasse 18, 1190 Vienna, Austria
    Mol Microbiol 78:720-38. 2010
    ..Our analysis using membrane-permeable NO donors suggests that signalling for NirA activation only indirectly depends on the nitrate transporters NrtA (CrnA) and NrtB (CrnB)...
  15. ncbi Regulation of nitric oxide (NO) production by plant nitrate reductase in vivo and in vitro
    Peter Rockel
    Forschungszentrum Julich GmbH, Institut für Biologie des Stoffaustauschs, 52425 Julich, Germany
    J Exp Bot 53:103-10. 2002
    ..It is concluded that in non-elicited leaves NO is produced in variable quantities by NR depending on the total NR activity, the NR activation state and the cytosolic nitrite and nitrate concentration...
  16. pmc Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite
    Andrew J Webb
    Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Hypertension 51:784-90. 2008
    ..These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a "natural" low cost approach for the treatment of cardiovascular disease...
  17. pmc The nitrate transporter AtNRT1.1 (CHL1) functions in stomatal opening and contributes to drought susceptibility in Arabidopsis
    Fang Qing Guo
    Section of Cell and Developmental Biology, Division of Biological Sciences, University of California at San Diego, La Jolla, California 92093 0116, USA
    Plant Cell 15:107-17. 2003
    ..These results identify an anion transporter that functions in stomatal opening and demonstrate that CHL1 supports stomatal function in the presence of nitrate...
  18. pmc Arabidopsis roots and shoots show distinct temporal adaptation patterns toward nitrogen starvation
    Anne Krapp
    Institut Jean Pierre Bourgin, Unité Mixte de Recherche 1318 INRA Agro ParisTech, F 78026 Versailles Cedex, France
    Plant Physiol 157:1255-82. 2011
    ..In the context of a sustainable agriculture, this work will give new insight for the production of crops with increased N use efficiency...
  19. ncbi Structure and mechanism of a nitrate transporter
    Hanchi Yan
    Ministry of Education Key Laboratory of Protein Science, Tsinghua University, Beijing 100084, China
    Cell Rep 3:716-23. 2013
    ..The observed conformational differences of NarU, together with unique sequence features of the NNP family transporters, suggest a transport mechanism that might deviate from the canonical rocker-switch model...
  20. ncbi From the soil to the seeds: the long journey of nitrate in plants
    Julie Dechorgnat
    Institut Jean Pierre Bourgin, UMR 1318 INRA AgroParisTech, Institut National de la Recherche Agronomique, Route de St Cyr, F 78026 Versailles, France
    J Exp Bot 62:1349-59. 2011
    ..All these fluxes are controlled by key factors, the 'major tour operators' like the internal nutritional status of the plant but also by external abiotic factors...
  21. ncbi Reduction of nitrate in Shewanella oneidensis depends on atypical NAP and NRF systems with NapB as a preferred electron transport protein from CymA to NapA
    Haichun Gao
    College of Life Sciences and Institute of Microbiology, Zhejiang University, Hangzhou, Zhejiang, China
    ISME J 3:966-76. 2009
    ..On the basis results from mutational analyses of napA, napB, nrfA and napBnrfA in-frame deletion mutants, we propose that NapB is able to favor nitrate reduction by routing electrons to NapA exclusively...
  22. pmc The Arabidopsis nitrate transporter NRT1.8 functions in nitrate removal from the xylem sap and mediates cadmium tolerance
    Jian Yong Li
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Plant Cell 22:1633-46. 2010
    ..8-1 mutant. These data suggest that NRT1.8-regulated nitrate distribution plays an important role in Cd(2+) tolerance...
  23. ncbi The nodule inception-like protein 7 modulates nitrate sensing and metabolism in Arabidopsis
    Loren Castaings
    Institut Jean Pierre Bourgin, Unité de Nutrition Azotée des Plantes, INRA, Route de St Cyr, F 78026 Versailles Cedex, France
    Plant J 57:426-35. 2009
    ..We propose NLP7 as an important element of the nitrate signal transduction pathway and as a new regulatory protein specific for nitrogen assimilation in non-nodulating plants...
  24. pmc Dissection of the AtNRT2.1:AtNRT2.2 inducible high-affinity nitrate transporter gene cluster
    Wenbin Li
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T1Z4
    Plant Physiol 143:425-33. 2007
    ..1. These findings suggest that NRT2.2 normally makes only a small contribution to IHATS, but when NRT2.1 is lost, this contribution increases, resulting in a partial compensation...
  25. ncbi Interactions between nitrogen and cytokinin in the regulation of metabolism and development
    Hitoshi Sakakibara
    RIKEN Plant Science Center, 1 7 22 Suehiro, Tsurumi, Yokohama 230 0045, Japan
    Trends Plant Sci 11:440-8. 2006
    ..The coordination and interaction of both regulatory pathways is important for normal plant growth under variable nitrogen supply conditions...
  26. pmc Predictive network modeling of the high-resolution dynamic plant transcriptome in response to nitrate
    Gabriel Krouk
    Department of Biology, New York University, Center for Genomics and Systems Biology, New York, NY 10003, USA
    Genome Biol 11:R123. 2010
    ..Nitrate, acting as both a nitrogen source and a signaling molecule, controls many aspects of plant development. However, gene networks involved in plant adaptation to fluctuating nitrate environments have not yet been identified...
  27. pmc Members of the LBD family of transcription factors repress anthocyanin synthesis and affect additional nitrogen responses in Arabidopsis
    Grit Rubin
    Max Planck Institute for Molecular Plant Physiology, Potsdam, Germany
    Plant Cell 21:3567-84. 2009
    ..They also show that, besides being developmental regulators, LBD genes fulfill roles in metabolic regulation...
  28. ncbi Nitrate regulation of metabolism and growth
    M Stitt
    Botanisches Institut, In Neuenheimer Feld 360, 69120, Heidelberg, Germany
    Curr Opin Plant Biol 2:178-86. 1999
    ..Signals derived from internal and external nitrate also adjust root growth and architecture to the physiological state of the plant, and the distribution of nitrate in the environment...
  29. pmc Mutation of the Arabidopsis NRT1.5 nitrate transporter causes defective root-to-shoot nitrate transport
    Shan Hua Lin
    Institute of Molecular Biology, Academia Sinica, Taipei 11529, Taiwan
    Plant Cell 20:2514-28. 2008
    ..5, another mechanism is responsible for xylem loading of nitrate. Further analyses of the nrt1.5 mutants revealed a regulatory loop between nitrate and potassium at the xylem transport step...
  30. pmc Nitrite as regulator of hypoxic signaling in mammalian physiology
    Ernst E van Faassen
    Department of Interface Physics, Debye Institute, Utrecht University, Princetonplein 1, 3508 TA Utrecht, The Netherlands
    Med Res Rev 29:683-741. 2009
    ..We here discuss the mechanisms and properties of these various pathways and the role played by the local concentration of free oxygen in the affected tissue...
  31. pmc Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane
    Lizheng Qin
    Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing 100050, China
    Proc Natl Acad Sci U S A 109:13434-9. 2012
    ..We suggest that the 2NO(3)(-)/H(+) transport function of sialin in salivary glands can contribute significantly to clearance of serum nitrate, as well as nitrate recycling and physiological nitrite-NO homeostasis...
  32. pmc N-fertilization has different effects on the growth, carbon and nitrogen physiology, and wood properties of slow- and fast-growing Populus species
    Hong Li
    Key laboratory of Applied Entomology, College of Plant Protection, Northwest Agriculture and Forestry University, Yangling, Shaanxi, 712100, PR China
    J Exp Bot 63:6173-85. 2012
    ....
  33. pmc Crystal structure of a nitrate/nitrite exchanger
    Hongjin Zheng
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nature 497:647-51. 2013
    ..We propose that NarK exchanges nitrate for nitrite by a rocker switch mechanism facilitated by inter-domain hydrogen bond networks...
  34. ncbi CLC-b-mediated NO-3/H+ exchange across the tonoplast of Arabidopsis vacuoles
    Jenny von der Fecht-Bartenbach
    Zentrum für Molekularbiologie der Pflanzen ZMBP, Pflanzenphysiologie, Universitat Tubingen, Auf der Morgenstelle 1, D 72076 Tubingen, Germany
    Plant Cell Physiol 51:960-8. 2010
    ..Both lines grew as the wild type in various conditions. The total chloride and nitrate content was identical in clcb lines and the wild type, potentially suggesting that mutants were able to compensate the loss of CLC-b...
  35. ncbi NTR1 encodes a high affinity oligopeptide transporter in Arabidopsis
    D Rentsch
    Institut fur Genbiologische Forschung, Berlin, Germany
    FEBS Lett 370:264-8. 1995
    ..In siliques NTR1-expression is restricted to the embryo, implicating a role in the nourishment of the developing seed...
  36. ncbi Nitrogen transfer in the arbuscular mycorrhizal symbiosis
    Manjula Govindarajulu
    Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, New Mexico 88003, USA
    Nature 435:819-23. 2005
    ..Strong changes in the expression of these genes in response to nitrogen availability and form also support the operation of this novel metabolic pathway in the arbuscular mycorrhizal symbiosis...
  37. ncbi Steps towards an integrated view of nitrogen metabolism
    Mark Stitt
    Max Planck Institute for Molecular Plant Physiology, Am Muhlenberg 1, 14476 Golm, Germany
    J Exp Bot 53:959-70. 2002
    ..Consequently, wild-type plants growing in unfavourable light regimes and antisense RBCS transformants are simultaneously carbon- and nitrogen-limited...
  38. pmc Arabidopsis V-ATPase activity at the tonoplast is required for efficient nutrient storage but not for sodium accumulation
    Melanie Krebs
    Heidelberg Institute for Plant Sciences, University of Heidelberg, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 107:3251-6. 2010
    ....
  39. ncbi Regulation of NRT1 and NRT2 gene families of Arabidopsis thaliana: responses to nitrate provision
    Mamoru Okamoto
    Department of Botany, University of British Columbia, 6270 University Blvd, Vancouver, V6T 1Z4, Canada
    Plant Cell Physiol 44:304-17. 2003
    ..1 and AtNRT1.1, respectively. Functional roles for the other members of these families remain uncertain...
  40. ncbi Biodegradation of benzene, toluene, and xylene (BTX) in liquid culture and in soil by Bacillus subtilis and Pseudomonas aeruginosa strains and a formulated bacterial consortium
    Ashis K Mukherjee
    Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784 028 Assam, India
    Environ Sci Pollut Res Int 19:3380-8. 2012
    ..This study highlighted the role of hydrogen peroxide (H(2)O(2)), nitrate, and phosphate in stimulating the biodegradation of BTX compounds under hypoxic condition...
  41. ncbi Characterization of a dual-affinity nitrate transporter MtNRT1.3 in the model legume Medicago truncatula
    Marie Christine Morère-Le Paven
    University of Angers, UMR 1191 Physiologie Moléculaire des Semences, IFR 149 QUASAV, 2 Boulevard Lavoisier, 49045 Angers cedex 01, France
    J Exp Bot 62:5595-605. 2011
    ..The results suggest that MtNRT1.3 is involved in the response to N limitation, which increases the ability of the plant to acquire NO(3)(-) under N-limiting conditions...
  42. pmc Widespread occurrence of nitrate storage and denitrification among Foraminifera and Gromiida
    Elisa Piña-Ochoa
    Center for Geomicrobiology, Department of Biological Sciences, Aarhus University, DK 8000 Aarhus C, Denmark
    Proc Natl Acad Sci U S A 107:1148-53. 2010
    ..miliolids, rotaliids, textulariids) and Gromia, another taxon also belonging to Rhizaria, accumulate and respire nitrates through denitrification...
  43. ncbi Gene structure and expression of the high-affinity nitrate transport system in rice roots
    Chao Cai
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Integr Plant Biol 50:443-51. 2008
    ..5, alkaline pH (pH 8.0) inhibited nitrate influx, and acidic pH (pH 5.0) enhanced the nitrate influx in 1 h nitrate induced roots, but did not significantly affect that in 4 to 8 h nitrate induced roots...
  44. pmc Genome sequences of Alicycliphilus denitrificans strains BC and K601T
    Margreet J Oosterkamp
    Laboratory of Microbiology, Wageningen University, Dreijenplein 10, 6703 HB, Wageningen, The Netherlands
    J Bacteriol 193:5028-9. 2011
    ..denitrificans strains BC and K601(T) were sequenced. Here, we report the complete genome sequences of A. denitrificans strains BC and K601(T)...
  45. pmc A central role for the nitrate transporter NRT2.1 in the integrated morphological and physiological responses of the root system to nitrogen limitation in Arabidopsis
    Tony Remans
    Laboratoire de Biochimie and Physiologie Moléculaire des Plantes, Unite Mixte de Recherche, Centre National de la Recherche Scientifique, Ecole Nationale Superieure Agronomique, Université Monpellier II, France
    Plant Physiol 140:909-21. 2006
    ....
  46. ncbi Vertical migration, nitrate uptake and denitrification: survival mechanisms of foraminifers (Globobulimina turgida) under low oxygen conditions
    Karoliina A Koho
    Faculty of Geosciences, Utrecht University, Utrecht, The Netherlands
    FEMS Microbiol Ecol 75:273-83. 2011
    ....
  47. ncbi TNF-alpha modulates iNOS expression in an experimental rat model of indomethacin-induced jejunoileitis
    Jyotirmoy Nandi
    Division of Gastroenterology, Department of Medicine, State University of New York, Upstate Medical University, 750 East Adams Street, Syracuse, NY 13210, USA
    Mol Cell Biochem 336:17-24. 2010
    ..Our data show TNF-alpha plays an early pro-inflammatory role in indomethacin-induced jejunoileitis. Additionally, down-regulation of NOx by PDE inhibitors, TNF-Ab, or HBO(2) suggests that TNF-alpha modulates iNOS expression...
  48. ncbi Nitrifier genomics and evolution of the nitrogen cycle
    Martin G Klotz
    Evolutionary and Genomic Microbiology Laboratory, Department of Biology, University of Louisville, Louisville, KY 40292, USA
    FEMS Microbiol Lett 278:146-56. 2008
    ....
  49. ncbi The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash
    Mirco Govoni
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, S 17177 Stockholm, Sweden
    Nitric Oxide 19:333-7. 2008
    ..The removal of these bacteria with an antibacterial mouthwash will very likely attenuate the NO-dependent biological effects of dietary nitrate...
  50. pmc Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1
    Claribel Cruz-García
    Center for Microbial Ecology, Michigan State University, East Lansing, Michigan 48824 1325, USA
    BMC Microbiol 11:64. 2011
    ..8% amino acid sequence identity with the oxygen-sensing regulators Fnr in E. coli and Anr in Pseudomonas aeruginosa, respectively; however, its regulatory role of anaerobic metabolism in Shewanella spp. is complex and not well understood...
  51. pmc The Arabidopsis nitrate transporter NRT1.7, expressed in phloem, is responsible for source-to-sink remobilization of nitrate
    Shu Chun Fan
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Plant Cell 21:2750-61. 2009
    ....
  52. pmc Use of organic nitrates and the risk of hip fracture: a population-based case-control study
    Sander Pouwels
    Utrecht Institute for Pharmaceutical Sciences, Division of Pharmacoepidemiology and Pharmacotherapy, University Utrecht, 3508 TB Utrecht, The Netherlands
    J Clin Endocrinol Metab 95:1924-31. 2010
    Use of organic nitrates has been associated with increased bone mineral density. Moreover, a large Danish case-control study reported a decreased fracture risk...
  53. ncbi Age and nutrient limitation enhance polyunsaturated aldehyde production in marine diatoms
    Francois Ribalet
    Stazione Zoologica Anton Dohrn di Napoli, Villa Comunale, I80121 Napoli, Italy
    Phytochemistry 68:2059-67. 2007
    ..e. chemical defense increase in aged and nutrient-stressed diatoms. If this holds true during blooms, grazers feeding at the end of a bloom would be more affected than early-bloom grazers...
  54. ncbi Expression profiles of 10,422 genes at early stage of low nitrogen stress in rice assayed using a cDNA microarray
    Xingming Lian
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research Wuhan, Huazhong Agricultural University, Wuhan 430070, China
    Plant Mol Biol 60:617-31. 2006
    ..The challenges for future studies are to characterize the functional roles of the low N stress responsive genes in N metabolisms, including the large number of genes presently with unknown functions...
  55. ncbi Municipal drinking water nitrate level and cancer risk in older women: the Iowa Women's Health Study
    P J Weyer
    Center for Health Effects of Environmental Contamination, University of Iowa, USA
    Epidemiology 12:327-38. 2001
    ..The positive association for bladder cancer is consistent with some previous data; the associations for ovarian, uterine, and rectal cancer were unexpected...
  56. ncbi Nitrate and nitrite transport in bacteria
    J W Moir
    Department of Molecular Biology and Biotechnology, University of Sheffield, Sheffield, United Kingdom
    Cell Mol Life Sci 58:215-24. 2001
    ..A hypothesis for nitrate and nitrite transport is proposed based on the finding that there are two distinct types of NarK...
  57. ncbi Regulation of a putative high-affinity nitrate transporter (Nrt2;1At) in roots of Arabidopsis thaliana
    D Zhuo
    Botany Department, University of British Columbia, Vancouver, Canada
    Plant J 17:563-8. 1999
    ..The use of inhibitors of N assimilation indicated that downregulation of Nrt2;1At expression was mediated by NH4+, gln and other amino acids...
  58. ncbi NarK is a nitrite-extrusion system involved in anaerobic nitrate respiration by Escherichia coli
    J J Rowe
    Department of Biology, University of Dayton, Ohio 45469 2320
    Mol Microbiol 12:579-86. 1994
    ..This process prevents intracellular accumulation of toxic levels of nitrite and allows further detoxification in the periplasm through the action of nitrite reductase...
  59. pmc The nasB operon and nasA gene are required for nitrate/nitrite assimilation in Bacillus subtilis
    K Ogawa
    Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan
    J Bacteriol 177:1409-13. 1995
    ..subtilis, which are required for nitrate/nitrite assimilation, is reported. The probable gene products include subunits of nitrate/nitrite reductases and an enzyme involved in the synthesis of siroheme, a cofactor for nitrite reductase...
  60. ncbi Degradation products of proteins damaged by glycation, oxidation and nitration in clinical type 1 diabetes
    N Ahmed
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 3SQ, UK
    Diabetologia 48:1590-603. 2005
    ....
  61. pmc Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons
    Eric J Benner
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 3:e1376. 2008
    ..We reasoned that PD-associated oxidative protein modifications create novel antigenic epitopes capable of peripheral adaptive T cell responses that could affect nigrostriatal degeneration...
  62. ncbi Characterization of an intact two-component high-affinity nitrate transporter from Arabidopsis roots
    Zhenhua Yong
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    Plant J 63:739-48. 2010
    ..The molecular mass of the intact oligomer suggests that the functional unit for high-affinity nitrate influx may be a tetramer consisting of two subunits each of AtNRT2.1 and AtNAR2.1...
  63. ncbi Biological and chemical sulfide oxidation in a Beggiatoa inhabited marine sediment
    André Preisler
    Department of Biogeochemistry, Max Planck Institute for Marine Microbiology, Bremen, Germany
    ISME J 1:341-53. 2007
    ..Indeed sulfide is a repellent for Beggiatoa...
  64. ncbi New insights into nitric oxide signaling in plants
    Angélique Besson-Bard
    Unité Mixte de Recherche Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Universite de Bourgogne, Plante Microbe Environnement, 21065 Dijon Cedex, France
    Annu Rev Plant Biol 59:21-39. 2008
    ..This review summarizes the basic concepts of NO signaling in animals and discusses new insights into NO enzymatic sources and molecular signaling in plants...
  65. ncbi Ammonia fermentation, a novel anoxic metabolism of nitrate by fungi
    Zhemin Zhou
    Institute of Applied Biochemistry, University of Tsukuba, Tsukuba, Ibaraki 305 8572, Japan
    J Biol Chem 277:1892-6. 2002
    ..We also showed that ammonia fermentation occurs in many other fungi that are common in soil, suggesting that facultative anaerobes are widely distributed among fungi that have been considered aerobic organisms...
  66. pmc Periplasmic nitrate reductase (NapABC enzyme) supports anaerobic respiration by Escherichia coli K-12
    Valley Stewart
    Section of Microbiology, University of California, O ne Shields Avenue, Davis, CA 95616 8665, USA
    J Bacteriol 184:1314-23. 2002
    ..181:5303-5308, 1999). This finding and other considerations support the hypothesis that NapABC enzyme may function in E. coli when low nitrate concentrations limit the bioenergetic efficiency of nitrate respiration via NarGHI enzyme...
  67. ncbi Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO
    Vikas Kapil
    William Harvey Research Institute, Barts and London Medical School, Queen Mary University of London, London, UK
    Hypertension 56:274-81. 2010
    ....
  68. ncbi S-Nitrosylation in plants: pattern and function
    Christian Lindermayr
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, D 85764 Neuherberg, Germany
    J Proteomics 73:1-9. 2009
    ..Furthermore, different methods for detection of S-nitrosothiols are highlighted and the function of S-nitrosylation in plants is discussed...
  69. pmc Nitrate and nitrite in biology, nutrition and therapeutics
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nat Chem Biol 5:865-9. 2009
    ..The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm...
  70. ncbi Regulation of the nitrate transporter gene AtNRT2.1 in Arabidopsis thaliana: responses to nitrate, amino acids and developmental stage
    Patricia Nazoa
    Biochimie and Physiologie Moléculaire des Plantes, UMR 5004 INRA CNRS Agro M UM 2, Place Viala, 34060 Montpellier Cedex 1, France
    Plant Mol Biol 52:689-703. 2003
    ..This lack of correlation between nitrate influx and NRT2.1 expression suggests that another high-affinity nitrate transporter operates in root tips...
  71. ncbi Protein targets of tyrosine nitration in sunflower (Helianthus annuus L.) hypocotyls
    Mounira Chaki
    Grupo de Señalización Molecular y Sistemas Antioxidantes en Plantas, Unidad Asociada al CSIC EEZ, Departamento de Bioquimica y Biologia Molecular, Universidad de Jaen, Spain
    J Exp Bot 60:4221-34. 2009
    ....
  72. pmc Genetic regulation by NLA and microRNA827 for maintaining nitrate-dependent phosphate homeostasis in arabidopsis
    Surya Kant
    Department of Molecular and Cellular Biology, University of Guelph, Guelph, Canada
    PLoS Genet 7:e1002021. 2011
    ..The results demonstrate that NLA and miR827 have pivotal roles in regulating Pi homeostasis in plants in a nitrate-dependent fashion...
  73. pmc Widespread metabolic potential for nitrite and nitrate assimilation among Prochlorococcus ecotypes
    Adam C Martiny
    Department of Earth System Science and Ecology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 106:10787-92. 2009
    ....
  74. pmc Biogenic magnetite formation through anaerobic biooxidation of Fe(II)
    S K Chaudhuri
    Department of Microbiology, Southern Illinois University, Carbondale, Illinois 62901, USA
    Appl Environ Microbiol 67:2844-8. 2001
    ..Here, we report on magnetite formation by biooxidation of Fe(II) coupled to denitrification. This metabolism offers an alternative environmental source of biogenic magnetite...
  75. ncbi The expanded family of ammonium transporters in the perennial poplar plant
    Jeremy Couturier
    Research Unit INRA UHP 1136 Tree microbe Interactions, Nancy University, BP 239, F 54506 Vandoeuvre les Nancy Cedex, France
    New Phytol 174:137-50. 2007
    ..The present study provides basic genomic and transcriptomic information for the poplar AMT family and will pave the way for deciphering the precise role of AMTs in poplar physiology...
  76. pmc The Arabidopsis ATNRT2.7 nitrate transporter controls nitrate content in seeds
    Franck Chopin
    Institut National de la Recherche Agronomique, Institut Jean Pierre Bourgin, Unité de la Nutrition Azotée des Plantes, F 78000 Versailles, France
    Plant Cell 19:1590-602. 2007
    ..7 or a mutation in the gene. Finally, we showed that this nitrate transporter protein was localized to the vacuolar membrane. Our results demonstrate that ATNRT2.7 plays a specific role in nitrate accumulation in the seed...
  77. ncbi Microbially catalyzed nitrate-dependent oxidation of biogenic solid-phase Fe(II) compounds
    K A Weber
    Department of Biological Sciences, University of Alabama, Tuscaloosa, Alabama 35487-0206, USA
    Environ Sci Technol 35:1644-50. 2001
    ..This process could have an important influence on the migration of contaminant metals and radionuclides in subsurface environments...
  78. ncbi Nitric oxide reduces seed dormancy in Arabidopsis
    Paul C Bethke
    Department of Plant and Microbial Biology, 111 Koshland Hall, University of California, Berkeley, CA 94720 3102, USA
    J Exp Bot 57:517-26. 2006
    ..It was confirmed that NO plays a role in reducing seed dormancy by using purified NO gas, and a model to explain how nitrogen-containing compounds may break dormancy in Arabidopsis is presented...
  79. ncbi Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats
    Chain Fa Su
    Department of Neurosurgery, Tzu Chi Hospital and Tzu Chi University, 701 Section 3 Chung Yang Road, Hualien 97004, Taiwan
    Clin Exp Pharmacol Physiol 34:339-46. 2007
    ..Inhibition of iNOS is effective in mitigating the endotoxaemic changes and lung pathology. Inhibitors of iNOS may be potential therapeutic agents for clinical application in patients with acute respiratory distress syndrome...
  80. ncbi Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes
    Jean Pierre Bassand
    Eur Heart J 28:1598-660. 2007
  81. pmc Catabolite repression control of napF (periplasmic nitrate reductase) operon expression in Escherichia coli K-12
    Valley Stewart
    Department of Microbiology, University of California, One Shields Avenue, Davis, CA 95616 8665, USA
    J Bacteriol 191:996-1005. 2009
    ..The results suggest that the Fnr and Crp proteins may act synergistically to enhance NapABC synthesis during growth with poor carbon sources to help obtain energy from low levels of nitrate...
  82. ncbi Peroxynitrite formation within the central nervous system in active multiple sclerosis
    A H Cross
    Department of Neurology and Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroimmunol 88:45-56. 1998
    ..These data suggest that peroxynitrite formation is a major consequence of NO produced in MS-affected CNS and implicate a role for this powerful oxidant in the pathogenesis of MS...
  83. pmc Physiological and evolutionary studies of NAP systems in Shewanella piezotolerans WP3
    Ying Chen
    Key Laboratory of MOE for Microbial metabolism and School of Life Sciences and Biotechnology, State Key Laboratory of Ocean Engineering, Shanghai Jiao Tong University, Shanghai, China
    ISME J 5:843-55. 2011
    ..Moreover, the data presented here will be very useful for the designed engineering of Shewanella for more efficient respiring capabilities for environmental bioremediation...
  84. ncbi The importance of nutritional regulation of plant water flux
    Michael D Cramer
    Department of Botany, University of Cape Town, Rondebosch, South Africa
    Oecologia 161:15-24. 2009
    ....
  85. ncbi Response of total and nitrate-dissimilating bacteria to reduced N deposition in a spruce forest soil profile
    Ellen Kandeler
    Institute of Soil Science and Land Evaluation, Soil Biology Section, University of Hohenheim, Stuttgart, Germany
    FEMS Microbiol Ecol 67:444-54. 2009
    ..An increase in the nosZ/16S rRNA gene and nosZ/nirK ratios with soil depth suggests that the proportion of denitrifiers capable of reducing N(2)O into N(2) is larger in the mineral soil layer than in the organic layer...
  86. pmc Nitrate intake and the risk of thyroid cancer and thyroid disease
    Mary H Ward
    Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, MD, USA
    Epidemiology 21:389-95. 2010
    ..Nitrate is a contaminant of drinking water in agricultural areas and is found at high levels in some vegetables. Nitrate competes with uptake of iodide by the thyroid, thus potentially affecting thyroid function...
  87. pmc Too much of a good thing? Nitrate from nitrogen fertilizers and cancer
    Mary H Ward
    Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Executive Plaza South, Room 8006, 6120 Executive Boulevard, Bethesda 20892 7240, Maryland, USA
    Rev Environ Health 24:357-63. 2009
    ..Studies should account for the potentially different effects of dietary and water sources of nitrate and should include the population using private wells for whom exposure levels are often higher than public supplies...
  88. ncbi Association between ACE inhibitors use and headache caused by nitrates among hypertensive patients: results from the Italian group of pharmacoepidemiology in the elderly (GIFA)
    G Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Rome, Italy
    Cephalalgia 23:901-6. 2003
    ..whether among hospitalized hypertensive patients use of ACE inhibitors may reduce the risk of headache caused by nitrates. To this end, we used the GIFA database, that includes patients admitted to academic medical centres throughout ..
  89. ncbi Inorganic nitrate is a possible source for systemic generation of nitric oxide
    Jon O Lundberg
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Free Radic Biol Med 37:395-400. 2004
    ..There are several pathways to further reduce this nitrite to NO. These results challenge the dogma that nitrate is biologically inert and instead suggest that a complete reverse pathway for generation of NO from nitrate exists...
  90. ncbi Expression of two maize putative nitrate transporters in response to nitrate and sugar availability
    S Trevisan
    Department of Agricultural Biotechnology, University of Padova, Legnaro, Italy
    Plant Biol (Stuttg) 10:462-75. 2008
    ..1 and ZmNrt2.2 transcription in the presence or absence of nitrate and the existence of both hexokinase-dependent and hexokinase-independent transduction mechanisms for the regulation of ZmNrt2.1 and ZmNrt2.2 expression by sugars...
  91. ncbi Large sulfur bacteria and the formation of phosphorite
    Heide N Schulz
    Institute for Microbiology, University of Hannover, Schneiderberg 50, D 30167 Hannover, Germany
    Science 307:416-8. 2005
    ..Laboratory experiments revealed that under anoxic conditions, Thiomargarita released enough phosphate to account for the precipitation of hydroxyapatite observed in the environment...
  92. ncbi Protein tyrosine nitration--an update
    Harry Ischiropoulos
    Stokes Research Institute and Departments of Pediatrics and Pharmacology, Children s Hospital of Philadelphia and The University of Pennsylvania, 417 Abramson Research Center, Philadelphia, PA 19104 4318, USA
    Arch Biochem Biophys 484:117-21. 2009
    ..Emerging data implicate tyrosine nitration as a mediator of immune responses suggesting a novel biological function for this protein modification...
  93. ncbi Pioglitazone and the risk of cardiovascular events in patients with Type 2 diabetes receiving concomitant treatment with nitrates, renin-angiotensin system blockers, or insulin: results from the PROactive study (PROactive 20)
    Erland Erdmann
    Medizinische Klinik III der Universität zu Köln, Koln, Germany
    J Diabetes 2:212-20. 2010
    ..The concomitant use of nitrates, renin-angiotensin system (RAS) blockers, or insulin has been linked to a potential increase in myocardial ..
  94. pmc A new class of organic nitrates: investigations on bioactivation, tolerance and cross-tolerance phenomena
    S Schuhmacher
    II Medizinische Klinik, Labor für Molekulare Kardiologie, Johannes Gutenberg Universitat, Mainz, Germany
    Br J Pharmacol 158:510-20. 2009
    The chronic use of organic nitrates is limited by serious side effects including oxidative stress, nitrate tolerance and/or endothelial dysfunction...
  95. ncbi Anoxic nitric oxide cycling in plants: participating reactions and possible mechanisms
    Abir U Igamberdiev
    Department of Biology, Memorial University of Newfoundland, St John s, NL, A1B 3X9, Canada
    Physiol Plant 138:393-404. 2010
    ..In normoxic conditions, NO is produced in very low quantities, mainly for signaling purposes and this nitrogen cycling is inoperative...
  96. pmc Factors that contribute to the misidentification of tyrosine nitration by shotgun proteomics
    Stanley M Stevens
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
    Mol Cell Proteomics 7:2442-51. 2008
    ....
  97. ncbi Growth on nitrate and occurrence of nitrate reductase-encoding genes in a phylogenetically diverse range of ectomycorrhizal fungi
    Cajsa M R Nygren
    Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, PO Box 7026, SE 750 07 Uppsala, Sweden
    New Phytol 180:875-89. 2008
    ..The results demonstrate that the ability to utilize nitrate as an N source is widespread in ECM fungi, even in those fungi from boreal forests where the supply of nitrate may be very low...
  98. ncbi Assessment of nitrate contamination due to groundwater pollution in north eastern part of Anantapur District, A.P. India
    A G S Reddy
    Central Ground Water Board, Ministry of Water Resources, Government of India, Hyderabad, India
    Environ Monit Assess 148:463-76. 2009
    ..Intense agriculture practices, improper sewerage and organic waste disposal methods were observed to contribute nitrate to the shallow and moderately deep aquifers...
  99. ncbi A new molecular tool for transgenic diatoms: control of mRNA and protein biosynthesis by an inducible promoter-terminator cassette
    Nicole Poulsen
    Biochemie I, Universitat Regensburg, Germany
    FEBS J 272:3413-23. 2005
    ..Altogether we have demonstrated that the Pnr/Tnr cassette enables inducible gene expression and control of both the level and timing of mRNA and protein expression in transgenic diatoms...
  100. pmc Identification of Arabidopsis mutants impaired in the systemic regulation of root nitrate uptake by the nitrogen status of the plant
    Thomas Girin
    Biochimie et Physiologie Moleculaire des Plantes, UMR 5004, INRA CNRS Sup Agro UM2, Institut de Biologie Integrative des Plantes, F 34060 Montpellier, France
    Plant Physiol 153:1250-60. 2010
    ..Altogether, our data indicate that the three hni mutants define a new class of N signaling mutants specifically impaired in the systemic feedback repression of root NO(3)(-) uptake...
  101. ncbi Stream denitrification across biomes and its response to anthropogenic nitrate loading
    Patrick J Mulholland
    Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Nature 452:202-5. 2008
    ....

Research Grants62

  1. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..g. pesticides), as well as trace amounts of hazardous materials such as arsenic, perchlorate, nitrates and nitrites...
  2. Role of Insulin Receptors in the Kidney
    CAROLYN MARY ECELBARGER; Fiscal Year: 2013
    ..They are also impaired in their ability to rapidly excrete a NaCl load, as well as, have blunted rise in urinary nitrates plus nitrites (a urinary form of NO) excretion in the basal state and after insulin treatment...
  3. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2011
    ..Bronchoalveolar (BAL) and lung mediators increased after i.t. LPS, among them BAL nitrites/nitrates (NOx)...
  4. Resolution and repair of acute lung injury by macrophage-derived iNOS
    FRANCO R D'ALESSIO; Fiscal Year: 2013
    ..Bronchoalveolar (BAL) and lung mediators increased after i.t. LPS, among them BAL nitrites/nitrates (NOx)...
  5. Iowa Center for Birth Defects Research and Prevention (ICBDRP)
    Paul A Romitti; Fiscal Year: 2013
    ..with rural exposures and residences that might adversely impact fetal development, particularly pesticides, nitrates in drinking water, and emerging zoonotic infections...
  6. Healing of Diabetic Ulcers with Gaseous Nitric Oxide Generated from Room Air
    Aristidis Veves; Fiscal Year: 2013
    ..Levels of wound fluid nitrates, a stable NO metabolite and biomarker, are depressed in DFUs that fail to heal, indicating that low NO ..
  7. Nitric Oxide Chimera Drugs for Colon Cancer Chemoprevention
    Gregory R J Thatcher; Fiscal Year: 2012
    ..NO-donor NSAIDs, which are aliphatic nitrates, were designed to utilize the biological activity of nitric oxide (NO) to counteract the GI side effects of ..
  8. Management and Outcomes of Heart Failure with Preserved Systolic Function
    Alan S Go; Fiscal Year: 2010
    ..g., diuretics, digoxin, nitrates, and statins). The public health burden for chronic heart failure is substantial-affecting 5...
  9. Targeting Wave Reflections in Heart Failure with Preserved Ejection Fraction
    JULIO ALONSO CHIRINOS MEDINA; Fiscal Year: 2013
    ..2) Test whether long-term vasoactive therapy with nitrates + hydralazine results in regression of LV hypertrophy (reduction in LV mass) and LV fibrosis in patients with ..
  10. DRUG SELF-ADMINISTRATION BY INHALATION IN THE PRIMATE
    Ronald Wood; Fiscal Year: 1991
    ..Blood levels will be determined. The abuse potential of alkyl nitrates will be characterized. Aversive properties...
  11. Noninvasive Methemoglobin Monitoring Technology
    LEONARD WINCHESTER; Fiscal Year: 2007
    ..and from pharmaceutical agents such as local anesthetics, acetaminophen, and drugs containing nitrites and/or nitrates. Children, especially those younger than four months of age, are particularly susceptible to methemoglobinemia...
  12. K Channel Plasticity and Regulation of Vasomotor Tone
    STEPHEN T O apos ROURKE; Fiscal Year: 2010
    ..Namely, that coincident with tolerance to the nitrates, blood vessels adapt by developing a compensatory relaxation pathway...
  13. Improved actions of nitrates and statins with L-arginine
    Ruth Caldwell; Fiscal Year: 2003
    ..that sustained elevated extracellular levels of L-arginine are required for optimal therapeutic effects of nitrates and the statins and that supplemental L-arginine will potentiate drug actions by reducing formation of SOA...
  14. Nitrative stress in heart failure
    Wai Hong Wilson Tang; Fiscal Year: 2013
    ..Interestingly, treatment of HF with nitric oxide (NO) donors such as nitrates has shown a resurgence in use due to demonstrated added clinical efficacy on top of traditional neurohormonal ..
  15. Primary Prevention of Hypertension in Obese Adolescents
    Daniel Feig; Fiscal Year: 2006
    ..to placebo, allopurinol or probenecid, for 2 months and screened for improvements in endothelial function (total nitrates, SVR, brachial artery reactivity), down-regulation of the RAS, and reduction of inflammation (MCP-1, hs-CRP)...
  16. METHODS OF HEMODYNAMIC STUDY AND REGULATION IN CIRRHOSIS
    John Henderson; Fiscal Year: 1991
    ..In parallel to this study, propranolol, verapamil, ketanserin and the nitrates, drugs which lower intrahepatic resistance, will be evaluated in stable patients with cirrhosis...
  17. STEROIDS /VASCULAR REACTIVITY /NITRIC OXIDE PRODUCTION
    Maureen Keller Wood; Fiscal Year: 2002
    ..Experiments will also determine plasma levels of nitrates and nitrites and the ability of infusion of L-NAME, an inhibitor of nitric oxide synthase (NOS), to increase ..
  18. NITRIC OXIDE AND SUPEROXIDE INTERACTIONS IN THE PLACENTA
    Leslie Myatt; Fiscal Year: 2002
    ..anion, a strong long-lived cytotoxic oxidant which inhibits mitochondrial electron transport and also nitrates tyrosine residues to block tyrosine-mediated signal transduction...
  19. Community Health Effects of Industrial Hog Operations
    Steven Wing; Fiscal Year: 2005
    ..b>Nitrates, pathogens, and antibiotic residues have been documented in ground water near swine CAFOs...
  20. Organic Nitrate Metabolism, Tolerance and Action
    Ho Leung Fung; Fiscal Year: 2010
    The long-term objective is to gain a better understanding of the mechanisms of action of organic nitrates. These important cardiovascular drugs, including nitroglycerin (NTG), are used for the acute relief of coronary ischemia and for ..
  21. S-nitrosylation of soluble guanylyl cyclase: potential role in nitrate tolerance
    Annie Beuve; Fiscal Year: 2009
    ..GTN), which induces vasodilation via NO generation, results in the loss of vasodilatory response to NO and nitrates. The mechanism of this nitrate tolerance is not understood, yet it is a major draw back to a widely used ..
  22. ENDOTHELIAL-DERIVED RELAXING FACTOR & PLATELET FUNCTION
    Michael Mendelsohn; Fiscal Year: 1993
    ..Given the known ability of nitrates and nitroxides to inhibit platelet aggregation and the role of the endothelium in maintaining vessel patency, we ..
  23. NITRIC OXIDE-G PROTEIN SIGNALING IN PATHOPHYSIOLOGY
    HARRY LANDER; Fiscal Year: 1999
    ..will extend these findings to an in vivo mouse system to determine whether NO-donating drugs such as the organic nitrates have hitherto undefined cell-stimulatory effects when given in vivo...
  24. NOVEL PHARMACOLOGICAL APPROACHES TO TREAT ANAL DISEASE
    Thomas Parks; Fiscal Year: 1999
    ..The topical use of organic nitrates, e.g. nitroglycerin (NTG), presents a promising new approach to treat anal fissure...
  25. HEMODYNAMIC PROBLEMS IN ARRHYTHMIA SURGERY
    HENRY SPOTNITZ; Fiscal Year: 1990
    ..effects of EP testing on LV function will be studied and interventions, including hypothermia, allopurinol and nitrates, will be investigated in an effort to minimize injury...
  26. WELL WATER NITRATE AND ASSOCIATED HEALTH EFFECTS
    Amadu Ayebo; Fiscal Year: 2000
    ..This study will allow for the investigation of the reproductive effects of nitrates. In addition, it will lay the foundation for studying the environmental influences of nitrate as well as other ..
  27. NITROGLYCERIN DINITRATE METABOLITES--KINETICS/DYNAMICS
    Leslie Benet; Fiscal Year: 1990
    ..We believe that much of the controversy in the literature concerning the efficacy of oral and long-acting nitrates might be explained in terms of the generation of sufficiently high concentrations of the dinitrate metabolites, ..
  28. NITRIC OXIDE EFFECTS ON CARDIOVASCULAR REACTIVITY
    Diane Tucker; Fiscal Year: 2002
    ..then have psychophysiologic testing with measures of BP, forearm blood flow, and plasma levels of NO metabolites (nitrates/nitrites) and catecholamines taken before and after two stressors (speech task and cold pressor)...
  29. Surfactant Proteins and NO in Inflammatory Disease
    Andrew Gow; Fiscal Year: 2006
    ..the lung (loss of S-nitrosothiol, SNO, and gain of nitrotyrosine within tissue and a relative greater increase of nitrates within the bronchiolar alveolar lavage, BAL)...
  30. SES, Environmental Factors and Colorectal Cancer Risk
    Amy Trentham Dietz; Fiscal Year: 2003
    ..risk factors including screening history; and (2) contaminants in drinking water - especially trihalomethanes, nitrates and pesticides - are associated with increased colorectal cancer risk...
  31. PEROXYNITRITE AND NITROTYROSINE IN HEART DISEASE
    JOSEPH BECKMAN; Fiscal Year: 2002
    ..Electrospray mass spectrometry has revealed that peroxynitrite preferentially nitrates certain tyrosine motifs in hydrophilic regions common to many structural proteins...
  32. Biologic Ventricular Assist Device
    Robert Kloner; Fiscal Year: 2004
    ..Identification and characterization of transplants will be carried out with PCR analysis of the Y chromosome (male cells into female host), detailed histologic analysis and immunostaining for muscle cell markers. ..
  33. Mesenchymal Stem Cells for Myocardial Infarction
    Robert Kloner; Fiscal Year: 2006
    ..abstract_text> ..
  34. COLLABORATIVE R01-CARDIAC GRAFTS-FUNCTIONAL ANALYSES
    Robert Kloner; Fiscal Year: 2003
    ....
  35. Nitric oxide mimetic NSAIDs for treatment of Alzheimer's Disease
    GREGORY THATCHER; Fiscal Year: 2007
    ..GT 1061 is 1 of a family of organic nitrates that have demonstrated neuroprotective as well as cognition-and memory-enhancing properties in a wide variety of ..
  36. Botanicals for Treatment of Depression
    GREGORY THATCHER; Fiscal Year: 2006
    ..A long term goal of the project, is the development of an in vitro screen for identifying antidepressant botanicals. ..
  37. NEUROSCIENCE TRAINING IN DRUG ABUSE
    DONALD KUHN; Fiscal Year: 2004
    ..abstract_text> ..
  38. PKC SIGNALING AND THE TREATMENT OF BIPOLAR DISORDER
    DONALD KUHN; Fiscal Year: 2002
    ....
  39. Case-Control Study of Head Injury in Relation to Ski He*
    Beth Mueller; Fiscal Year: 2005
    ..abstract not provided ..
  40. ETHANOL, INSULIN/IGF SIGNALING AND NEURONAL MIGRATION
    Suzanne de la Monte; Fiscal Year: 2008
    ..abstract_text> ..
  41. MICROARRAY ANALYSIS OF HUMAN COCAINE ADDICTS
    DONALD KUHN; Fiscal Year: 2002
    ..Microarray-based scanning of the human genome has the potential to establish those genes or gene clusters that define the addictive phenotype, leading the way to proteomic-based studies of the bases of addiction. ..
  42. Smoking During Pregnancy and Breast Cancer
    Beth Mueller; Fiscal Year: 2003
    ....
  43. Methamphetamine Neurotoxicity and Microglial Activation
    DONALD KUHN; Fiscal Year: 2009
    ..A better understanding of the mechanisms by which METH causes persistent damage to the DA neuronal system could lead to more targeted therapies and would open newer lines of investigation into this and other neurotoxic drugs of abuse. ..
  44. Molecular Neurobiology of Drug Abuse
    DONALD KUHN; Fiscal Year: 2006
    ..Kuhn will remain extensively engaged in scientific mentoring activities. ..
  45. Gene-Environment Factors in Childhood Brain Tumors
    Beth Mueller; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  46. Use of Water Quality Surveillance Data in Epidemiologic*
    Beth Mueller; Fiscal Year: 2003
    ..these databases have existed for several decades, containing information about levels of contaminants such as nitrates, arsenic, or pesticides in drinking water supplies...
  47. Exploring Gene-Environment Factors in Child Brain Tumors
    Beth Mueller; Fiscal Year: 2004
    ..abstract_text> ..
  48. Nitrates, Nitrites, and Nitrosatable Drugs and Risk of Selected Birth Defects
    JEAN DIANE BRENDER; Fiscal Year: 2010
    ..The few epidemiologic studies conducted in the past have focused on the separate effects of nitrates, nitrites, and nitrosatable drugs on risk of congenital malformations without consideration of their interaction ..
  49. GENETIC CONTROL OF NITRATE RESPIRATION IN E. COLI
    Valley J Stewart; Fiscal Year: 2010
    ..Thus, results from the model species E. coli enhance understanding for a broad range of pathogens that significantly impact public health. ..
  50. NOVEL CLINICAL CHEMISTRY SENSING MOTIF
    Sanford Asher; Fiscal Year: 2009
    ..The analyte sensing will be monitored by using a simple Palm Pilot-type instrument that utilizes a color CCD camera. The results could be immediately displayed, and easily recorded if the device is operated as a patient biographer. ..
  51. Role of Stretch to Endothelial Pulse-Perfusion Response
    David Kass; Fiscal Year: 2005
    ..abstract_text> ..
  52. Role of nitric oxide and eicosanoids in lupus nepthritis
    James Oates; Fiscal Year: 2005
    ..In either event, future studies would address the use of selective COX-2 or TXA2 synthase inhibitors/receptor blockers, antioxidants, and/or PGI2/PGE2 agonists in conduction with iNOS inhibitors as therapies for LN. ..
  53. Genetic Predictors of Outcome in Acute MI
    Marc Sabatine; Fiscal Year: 2005
    ..Genomic control will be employed to detect and control for population stratification. Interaction terms will be incorporated into regression models to explore gene-environment and pharmacogenomic interactions. ..
  54. Lipid Testing /Treatment in Older MI Patients
    JoAnne Foody; Fiscal Year: 2005
    ..This work will ultimately improve care for the elderly patient with cardiovascular disease. ..
  55. Oral Peptide Conjugate to Treat Congestive Heart Failure
    Kenneth James; Fiscal Year: 2003
    ..Phase II studies will involve pharmacokinetic and pharmacodynamic studies of the most promising candidates arising from Phase I studies. ..
  56. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  57. MECHANISMS OF SULFATE TRANSPORT AND REGULATION
    Michael Jennings; Fiscal Year: 2007
    ..abstract_text> ..
  58. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  59. UV RESONANCE RAMAN STUDIES OF PROTEIN STRUCTURE
    Sanford Asher; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  60. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..