clemastine

Summary

Summary: A histamine H1 antagonist used as the hydrogen fumarate in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

Top Publications

  1. ncbi Development and full validation of a sensitive quantitative assay for the determination of clemastine in human plasma by liquid chromatography-tandem mass spectrometry
    Zhiyong Xie
    Laboratory of Pharmaceutical Analysis and Quality Assessment, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    J Pharm Biomed Anal 44:924-30. 2007
  2. ncbi Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification
    Annica Tevell Aberg
    Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute SVA, Uppsala, Sweden
    Rapid Commun Mass Spectrom 24:1447-56. 2010
  3. ncbi A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis
    L Frølund
    State University Hospital, Copenhagen, Denmark
    Allergy 45:254-61. 1990
  4. ncbi Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine
    C M Pratt
    Department of Internal Medicine, Baylor College of Medicine, Houston, Texas 77030
    Am J Cardiol 73:346-52. 1994
  5. ncbi Allergen-induced increase in airway responsiveness is not inhibited by acute treatment with ketotifen or clemastine
    D W Cockcroft
    Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    Ann Allergy 68:245-50. 1992
  6. ncbi Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus
    B Abila
    Department of Pharmacology, College of Medicine, University of Port Harcourt, Nigeria
    J Trop Med Hyg 92:356-9. 1989
  7. ncbi Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel
    John M Ridley
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Mol Cell Cardiol 40:107-18. 2006
  8. pmc Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations
    Wolfgang Nörenberg
    Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
    J Biol Chem 286:11067-81. 2011
  9. ncbi Dose reduction of steroid premedication for paclitaxel: no increase of hypersensitivity reactions
    H Koppler
    Praxis für Hämatologie und Onkologie, Neverstrasse 5, D 56058 Koblenz, Germany
    Onkologie 24:283-5. 2001
  10. ncbi Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry
    Annica Tevell
    Division of Analytical Pharmaceutical Chemistry, Uppsala University, BMC, SE 751 23 Uppsala, Sweden
    Rapid Commun Mass Spectrom 18:2267-72. 2004

Research Grants

Scientific Experts

Detail Information

Publications117 found, 100 shown here

  1. ncbi Development and full validation of a sensitive quantitative assay for the determination of clemastine in human plasma by liquid chromatography-tandem mass spectrometry
    Zhiyong Xie
    Laboratory of Pharmaceutical Analysis and Quality Assessment, School of Pharmaceutical Sciences, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, China
    J Pharm Biomed Anal 44:924-30. 2007
    ..chromatography-tandem mass spectrometry (LC/MS/MS) method was developed and validated for the determination of clemastine in human plasma...
  2. ncbi Structural elucidation of N-oxidized clemastine metabolites by liquid chromatography/tandem mass spectrometry and the use of Cunninghamella elegans to facilitate drug metabolite identification
    Annica Tevell Aberg
    Department of Chemistry, Environment and Feed Hygiene, National Veterinary Institute SVA, Uppsala, Sweden
    Rapid Commun Mass Spectrom 24:1447-56. 2010
    ..In this paper we describe the use of C. elegans to aid the identification of clemastine metabolites since high concentrations of the metabolites were produced and MS(n) experiments were facilitated...
  3. ncbi A multicentre study of loratadine, clemastine and placebo in patients with perennial allergic rhinitis
    L Frølund
    State University Hospital, Copenhagen, Denmark
    Allergy 45:254-61. 1990
    ..parallel-group study compared 3 weeks' treatment with either loratadine (Clarityn) 10 mg once daily, or clemastine (Tavegyl) 1 mg twice daily, and placebo in outpatients with active perennial allergic rhinitis...
  4. ncbi Risk of developing life-threatening ventricular arrhythmia associated with tefenadine in comparison with over-the-counter antihistamines, ibuprofen and clemastine
    C M Pratt
    Department of Internal Medicine, Baylor College of Medicine, Houston, Texas 77030
    Am J Cardiol 73:346-52. 1994
    ..included terfenadine (n = 181,672), over-the-counter antihistamines (n = 150,689), ibuprofen (n = 181,672) and clemastine (Tavist; n = 83,156)...
  5. ncbi Allergen-induced increase in airway responsiveness is not inhibited by acute treatment with ketotifen or clemastine
    D W Cockcroft
    Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    Ann Allergy 68:245-50. 1992
    ..A single-blind, crossover, random-order trial was conducted to compare ketotifen, clemastine, and placebo in six atopic subjects undergoing allergen inhalation tests...
  6. ncbi Effects of clemastine, ketotifen and prednisolone on chloroquine-induced pruritus
    B Abila
    Department of Pharmacology, College of Medicine, University of Port Harcourt, Nigeria
    J Trop Med Hyg 92:356-9. 1989
    The effects of single doses of placebo, clemastine, ketotifen and prednisolone on chloroquine-induced pruritus were investigated in healthy black African volunteers using a visual analogue scale...
  7. ncbi Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel
    John M Ridley
    Department of Physiology and Cardiovascular Research Laboratories, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Mol Cell Cardiol 40:107-18. 2006
    ..This study investigated the effects on HERG channel current (IHERG) of clemastine, a "conventional" antihistamine that has been associated with delayed ventricular repolarization in vitro, but ..
  8. pmc Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations
    Wolfgang Nörenberg
    Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
    J Biol Chem 286:11067-81. 2011
    ..Of these, clemastine markedly sensitized Ca(2+) entry through P2X7 to lower ATP concentrations...
  9. ncbi Dose reduction of steroid premedication for paclitaxel: no increase of hypersensitivity reactions
    H Koppler
    Praxis für Hämatologie und Onkologie, Neverstrasse 5, D 56058 Koblenz, Germany
    Onkologie 24:283-5. 2001
    Premedication with dexamethasone, ranitidine and clemastine is mandatory for patients receiving paclitaxel to avoid hypersensitivity reactions. The proposed dexamethasone dose is 20 mg orally 12 and 6 h prior to paclitaxel infusion...
  10. ncbi Identification of some new clemastine metabolites in dog, horse, and human urine with liquid chromatography/tandem mass spectrometry
    Annica Tevell
    Division of Analytical Pharmaceutical Chemistry, Uppsala University, BMC, SE 751 23 Uppsala, Sweden
    Rapid Commun Mass Spectrom 18:2267-72. 2004
    The metabolism of clemastine was studied in dogs, horses, and humans after a single dose of Tavegyl...
  11. ncbi Placebo controlled comparison of acute effects of ebastine and clemastine on performance and EEG
    H Hopes
    Department of Clinical Pharmacology, Laboratory for Experimental Psychopharmacology, E Merck, Darmstadt, FRG
    Eur J Clin Pharmacol 42:55-9. 1992
    The effects of single oral doses of 10 and 20 mg ebastine were compared with placebo and 2 mg clemastine in a double-blind cross-over study in 16 healthy male volunteers...
  12. ncbi Clinical evaluation of ketotifen for chronic urticaria: multicenter double-blind comparative study with clemastine
    R Kamide
    Department of Dermatology, Jikei University, School of Medicine, Tokyo, Japan
    Ann Allergy 62:322-5. 1989
    A double-blind study was performed in 305 patients to compare ketotifen capsule and clemastine tablet. Ketotifen alleviated eruption and itching to a significantly greater extent than clemastine...
  13. ncbi Safety and efficacy of terfenadine/pseudoephedrine versus clemastine/phenylpropanolamine in the treatment of seasonal allergic rhinitis
    A T Segal
    Allergy Associates Research, Dallas, Texas
    Ann Allergy 70:389-94. 1993
    ..of terfenadine, 60 mg (immediate-release)/pseudoephedrine hydrochloride, 120 mg (controlled-release) (T/Ps) and clemastine fumarate, 1...
  14. ncbi [Emergency checklist: angioedema]
    H S Füeessl
    Leiter Somatischer Ouerschnittsbereich, Isar Amper Klinikum, Klinikum München Ost, Ringstr 33a, D 85540 Haar
    MMW Fortschr Med 149:33. 2007
  15. ncbi Spectrophotometric determination of some histamine H1-antagonists drugs in their pharmaceutical preparations
    Wafaa S Hassan
    Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
    Spectrochim Acta A Mol Biomol Spectrosc 69:245-55. 2008
    ..g., chlorphenoxamine hydrochloride (CPX), diphenhydramine hydrochloride (DPH) and clemastine (CMT) in bulk and in their pharmaceutical formulations...
  16. ncbi [Diagnostic image (283). A man with a swollen tongue]
    M Oosterloo
    Centrale Spoedopvang, Universitair Medisch Centrum Groningen, Groningen
    Ned Tijdschr Geneeskd 150:1617. 2006
    ..A 70-year-old man presented with a swollen tongue caused by an angiotensin-converting enzyme inhibitor...
  17. ncbi Role of histamine receptors in the regulation of edema and circulation postburn
    Johanna Räntfors
    Department of Paediatric Surgery, Queen Silvia Children s Hospital, Goteborg, Sweden
    Burns 29:769-77. 2003
    ..We used the selective antagonists clemastine (H(1)), ranitidine (H(2)), thioperamide (H(3)) and the selective H(3) receptor agonist, imetit...
  18. ncbi Anti-oedematous action of some H1-receptor antagonists
    G Blazso
    Institute of Pharmacodynamics, Albert Szent Györgyi, Medical University, Szeged, Hungary
    Agents Actions 42:13-8. 1994
    ..was used to study the effects of orally administered H1-receptor antagonists (cetirizine, chloropyramine, clemastine, cyproheptadine, dimethindene, loratadine, mequitazine and terfenadine) on the inflammation induced with ..
  19. ncbi Acrivastine. A review of its pharmacological properties and therapeutic efficacy in allergic rhinitis, urticaria and related disorders
    R N Brogden
    ADIS Drug Information Services, Auckland, New Zealand
    Drugs 41:927-40. 1991
    ..Acrivastine was more effective than placebo and similar in efficacy to clemastine or terfenadine in the treatment of seasonal allergic rhinitis...
  20. ncbi Evaluation of efficacy and sedative profiles of H(1) antihistamines by large-scale surveillance using the visual analogue scale (VAS)
    Norimasa Izumi
    Department of Molecular Pharmacology, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    Allergol Int 57:257-63. 2008
    ..However, it is not easy to obtain these parameters. Here, we sought to evaluate the sedative properties of H(1) antihistamines by means of a large-scale surveillance at health insurance pharmacies...
  21. pmc Pharmacological prevention of serious anaphylactic reactions due to iodinated contrast media: systematic review
    Martin R Tramer
    Division of Anaesthesiology, Geneva University Hospitals, CH 1211 Geneva, Switzerland
    BMJ 333:675. 2006
    ..To review the efficacy of pharmacological prevention of serious reactions to iodinated contrast media...
  22. ncbi Acrivastine in seasonal allergic rhinitis: two randomized crossover studies to evaluate efficacy and safety
    T G Gibbs
    Wellcome Research Laboratories, Beckenham, UK
    J Int Med Res 16:413-9. 1988
    ..The other study found the higher dosage regimen to be similar in efficacy to 1 mg clemastine given three times daily...
  23. ncbi Inhibitory effect of olopatadine hydrochloride on the sneezing response induced by intranasal capsaicin challenge in guinea pigs
    T Kaise
    Department of Pharmacology, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co, Ltd, Sunto gun, Shizuoka, Japan
    Jpn J Pharmacol 86:258-61. 2001
    ..The antihistamines chlorpheniramine and clemastine did not affect the responses...
  24. ncbi Anti-inflammatory effects of low-intensity extremely high-frequency electromagnetic radiation: frequency and power dependence
    A B Gapeyev
    Institute of Cell Biophysics of Russian Academy of Sciences, Pushchino, Moscow Region, Russia
    Bioelectromagnetics 29:197-206. 2008
    ..Combined action of antihistamine clemastine and EHF EMR exposure caused a dose-dependent abolishment of the anti-inflammatory effect of EHF EMR...
  25. ncbi Simultaneous screening and quantitation of 18 antihistamine drugs in blood by liquid chromatography ionspray tandem mass spectrometry
    M Gergov
    Department of Forensic Medicine, University of Helsinki, P O Box 40, FIN 00014 Helsinki, Finland
    Forensic Sci Int 121:108-15. 2001
    ..The limits for identification by Product Ion Spectra were also lower than C(max), except for clemastine, which has exceptionally low concentrations in blood...
  26. ncbi Capillary gas chromatographic determination of phenylpropanolamine in pharmaceutical preparation
    K Abbasi
    National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, Pakistan
    J Pharm Biomed Anal 41:998-1001. 2006
    ..0 microg/ml. The method was used for the determination of PPA from Sinutab and Tavegyl-D tablets. The relative standard deviation (R.S.D.) for the analysis of pharmaceutical preparation was obtained within 0.4-0.9%...
  27. ncbi Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94
    J F O'Hanlon
    Institute for Human Psychopharmacology, University of Limburg, Maastricht, The Netherlands
    Allergy 50:234-42. 1995
    ..driving performance of "sedating" and "nonsedating" antihistamines (respectively, triprolidine, diphenhydramine, clemastine and terfenadine, loratadine, cetirizine, acrivastine, mizolastine, and ebastine)...
  28. ncbi [Appearance diagnosis. Facial shingles]
    Petra Mehling
    Allgemeinmedizin, Höchberg
    MMW Fortschr Med 146:60. 2004
  29. ncbi Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorus detection
    N N Davydova
    Department of Pharmacology, School of Medicine, Georgetown University, Washington, DC 20007, USA
    J Chromatogr B Biomed Sci Appl 744:177-81. 2000
    A method for the quantitative determination of clemastine in human plasma has been developed and validated. The assay uses gas chromatography with nitrogen-phosphorus detection and a HP-1 capillary column (25 mx0.22 mm, film thickness 0...
  30. ncbi Serious allergic reaction to administration of epirubicin
    R Oltmans
    Department of Internal Medicine, Mesos Medical Centre, van Heuven Goedhartlaan 1, 3527 CE Utrecht, The Netherlands
    Neth J Med 61:226-7. 2003
    ..Treatment with clemastine 2 mg iv caused a quick recovery and after 24 hours there was only a slight redness of the face...
  31. ncbi Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry
    Chika Hasegawa
    Department of Legal Medicine, Showa University School of Medicine, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Rapid Commun Mass Spectrom 20:537-43. 2006
    ..diphenylpyraline, triprolidine, promethazine, homochlorcyclizine, cyproheptadine, cloperastine and clemastine, have been found to be extractable from human plasma samples using MonoTip C18 tips, inside which C18- bonded ..
  32. ncbi Docetaxel and cisplatin in metastatic urothelial cancer: a phase II study
    L Sengeløv
    Department of Oncology, Herlev University Hospital, Denmark
    J Clin Oncol 16:3392-7. 1998
    ..We performed a phase II study in which docetaxel was combined with cisplatin to evaluate response rate, toxicity, and survival...
  33. pmc Itch and skin rash from chocolate during fluoxetine and sertraline treatment: case report
    Jonas Cederberg
    Department of Clinical Chemistry and Pharmacology, Uppsala Academic Hospital, Uppsala, Sweden
    BMC Psychiatry 4:36. 2004
    ..Serotonin can also cause pruritus when injected into the skin. SSRI-drugs increase serotonin concentrations and are known to have pruritus and other dermal side effects...
  34. ncbi [Multilocular painful urticarial plaques. Eosinophilic cellulitis (Wells syndrome)]
    P Bützberger Zimmerli
    Medizinische Klinik, Kantonsspital Aarau
    Praxis (Bern 1994) 93:1831-5. 2004
  35. ncbi Binding of histamine-albumin conjugates to human lymphocytes: evidence for labelling of histamine H-1 but not H-2 receptors
    T Hallberg
    Department of Medical Microbiology, Lund University, Sweden
    Acta Pathol Microbiol Immunol Scand C 95:199-205. 1987
    ..The histamine H-1 receptor antagonists clemastine, mepyramine, and diphenhydramine efficiently inhibited lymphocyte binding of the histamine-albumin conjugate ..
  36. ncbi Pretreatment synovial transcriptional profile is associated with early and late clinical response in rheumatoid arthritis patients treated with rituximab
    Vanessa E Hogan
    Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, UK
    Ann Rheum Dis 71:1888-94. 2012
    ..The authors aimed to develop a gene expression signature in synovial tissue that could enrich clinical response of rheumatoid arthritis (RA) patients to rituximab...
  37. ncbi [Progress of study on antitumor effects of antibody dependent cell mediated cytotoxicity--review]
    Yu Hua Qu
    Department of Pediatrics, Sun Yet Sen Memorial Hospital, Sun Yet Sen University, Guangzhou 510120, Guangdong Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:1370-5. 2010
    ..Avoiding use of certain drugs (dexamethasone, TNF antagonist) or appropriately using of ondansetron and clemastine also can enhance the anti-tumor effect of ADCC mediated by monoclonal antibodies...
  38. ncbi Mast cell degranulation as a major event in the effector phase of delayed-type hypersensitivity induced by cloned helper T cells
    P Herrmann
    Preclinical Research, Sandoz Ltd, Basel, Switzerland
    Int Arch Allergy Appl Immunol 86:102-5. 1988
    ..These results suggest a local and systemic cascade in DTH which depends on mast cell degranulation for its full expression...
  39. ncbi Antagonists of PAF and histamine inhibit ouabain-induced cardiac arrhythmias in sensitized guinea-pigs
    H J Mest
    Department of Pharmacology and Toxicology, Martin Luther University, Halle, GDR
    Pol J Pharmacol Pharm 42:283-9. 1990
    ..Antagonists of PAF (BN 52021, WEB 2086, WEB 2170) and histamine antagonist clemastine can increase the threshold dose of ouabain-induced arrhythmia...
  40. ncbi Kinetic aspects of hollow fiber liquid-phase microextraction and electromembrane extraction
    Astrid Gjelstad
    School of Pharmacy, University of Oslo, Oslo, Norway
    Anal Chim Acta 742:10-6. 2012
    ..electromembrane extraction (EME) with the basic drugs droperidol, haloperidol, nortriptyline, clomipramine, and clemastine as model analytes...
  41. ncbi Medication with antihistamines impairs allergen-specific immunotherapy in mice
    P Johansen
    Unit for Experimental Immunotherapy, Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Clin Exp Allergy 38:512-9. 2008
    ..Histamine released from activated mast cells and basophils is an important mediator in allergy. Therefore, antihistamines are efficiently and widely used to suppress allergic symptoms...
  42. ncbi Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia
    Junji Saruwatari
    Division of Pharmacology and Therapeutics, Graduate School of Medical and Pharmaceutical Sciences, Kumamoto University, Oe honmachi 5 1, Kumamoto 862 0973, Japan
    Eur J Clin Pharmacol 62:995-1001. 2006
    ..This study investigated the relevance of the cytochrome P450 (CYP) 2D6 genotype to the adverse drug reactions (ADRs) of H1-antihistamines and the level of sedation...
  43. ncbi Psoriasis following growth hormone therapy in a child
    Ozgur Pirgon
    Faculty of Medicine, Department of Pediatric Endocrinology, Selcuk University, Konya, Turkey
    Ann Pharmacother 41:157-60. 2007
    ..To report a case of psoriasis that developed following growth hormone treatment...
  44. pmc Histamine and allergen induced changes in nasal airways resistance measured by anterior rhinomanometry: reproducibility of the technique and the effect of topically administered antihistaminic and anti-allergic drugs
    O J Corrado
    Academic Department of Respiratory Medicine, St Bartholomew s Hospital, London
    Br J Clin Pharmacol 24:283-92. 1987
    ..5. The effects of sodium cromoglycate (SCG), clemastine and ketotifen administered to the nasal mucosa 30 min before provocation with histamine and allergen were ..
  45. ncbi Role of histamine in the chemotactic deactivation of polymorphonuclear leukocytes following incubation with formylmethionyl peptides
    T Bury
    Department of Respiratory Medicine, CHU Sart Tilman, University of Liege, Belgium
    Int Arch Allergy Immunol 97:109-14. 1992
    ..These results show that histamine which is released during leukocyte incubation with FMP, contributes, at least in part, to the chemotactic deactivation of PMN...
  46. ncbi Synthesis of (-)-(S,S)-clemastine by invertive N --> C aryl migration in a lithiated carbamate
    Anne M Fournier
    School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, UK
    Org Lett 12:2222-5. 2010
    The first enantioselective synthesis of the antihistamine agent clemastine, as its (S,S)-stereoisomer, has been achieved by ether formation between a proline-derived chloroethylpyrrolidine and an enantiomerically enriched tertiary alcohol...
  47. ncbi Inhibition of mast cell degranulation-induced drop of blood pressure with clemastine, cromolyn and compound 48/80 pretreatment
    L Peternel
    Drug Discovery, Lek Pharmaceuticals d d, 1526, Ljubljana, Slovenia
    Inflamm Res 55:S07-8. 2006
  48. ncbi Efficacy and safety of clemastine-pseudoephedrine-acetaminophen versus pseudoephedrine-acetaminophen in the treatment of seasonal allergic rhinitis in a 1-day, placebo-controlled park study
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center, San Diego, California, USA
    Ann Allergy Asthma Immunol 90:79-86. 2003
    ..Patients with allergic rhinitis have a wide range of symptoms that are often treated with oral combination products that contain antihistamines, decongestants, and analgesics...
  49. ncbi Why aren't lower, effective, OTC doses available earlier by prescription?
    Jay S Cohen
    Department of Family and Preventive Medicine, Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
    Ann Pharmacother 37:136-42. 2003
    ..Yet, if OTC doses are effective for treating mild symptoms, why weren't these low, often safer doses made available at least by prescription when the drugs were first approved?..
  50. ncbi Randomized trial of single agent paclitaxel given weekly versus every three weeks and with peroral versus intravenous steroid premedication to patients with ovarian cancer previously treated with platinum
    Per Rosenberg
    Department of Gynecological Oncology, University Hospital, Linkoping, Sweden
    Acta Oncol 41:418-24. 2002
    ..Weekly paclitaxel at a dose of 67 mg/m2/week was found to have a better safety profile and seemed to be as effective as the equivalently dosed schedule every 3 weeks. Intravenous steroids are a safe alternative to oral steroids...
  51. ncbi Evaluation of the separation mechanism of electrokinetic chromatography with a microemulsion and cyclodextrins using NMR and molecular modeling
    Fabrizio Melani
    Department of Pharmaceutical Sciences, University of Florence, Sesto Fiorentino, Italy
    Electrophoresis 32:3062-9. 2011
    ..The above dual cyclodextrin-microemulsion system was previously used in the separation of clemastine and its related substances and was prepared by the addition of methyl-β-cyclodextrin (MβCD) and heptakis(2,6-..
  52. ncbi [Angioneurotic orolingual edema associated with the use of rt-PA following a stroke]
    R Laubinger
    Klinik für Anaesthesie und operative Intensivtherapie, Südharz Krankenhaus, Nordhausen
    Anaesthesist 56:1024-7. 2007
    ..It was possible to avoid intubation and ventilation in both cases. Therapy with ranitidine, clemastine, and a C1 esterase inhibitor resulted in the resolution of symptomatic angioneurotic edema within hours.
  53. pmc Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens
    J S Kloover
    Department of Pulmonology, Erasmus MC, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Br J Cancer 90:304-5. 2004
    ..The level of evidence supporting the short-course i.v. premedication schedule is challenged, as it is not compatible with the pharmacokinetic properties of dexamethasone...
  54. ncbi Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic
    Joris C Verster
    Utrecht Institute for Pharmaceutical Sciences, Department of Psychopharmacology, University of Utrecht, Utrecht, The Netherlands
    Ann Allergy Asthma Immunol 92:294-303; quiz 303-5, 355. 2004
    ..All antihistamines are capable of crossing the blood-brain barrier and thus may cause sedation. Most antihistamine users are ambulatory patients and therefore presumably drive a car...
  55. ncbi Dermatopathic lymphadenopathy: a differential diagnosis of enlarged lymph nodes in uremic pruritus
    T H Westhoff
    Charite, Campus Benjamin Franklin, Medizinische Klinik IV, Nephrology, Hindenburgamm 30, 12200 Berlin, Germany
    Clin Nephrol 66:472-5. 2006
    ..In the present work we describe a rare but probably underdiagnosed cause for enlarged lymph nodes in uremic patients...
  56. ncbi Influence of immunomodulatory drugs on the cytotoxicity induced by monoclonal antibody 17-1A and interleukin-2
    Dimitri Flieger
    Medizinische Klinik und Poliklinik I, Allgemeine Innere Medizin, Universitat Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Cell Immunol 246:26-33. 2007
    ..Ondansetron, a 5-HT-3 serotonin receptor antagonist augmented significantly ADCC. Clemastine, a histamine type-2 receptor antagonist augmented the IL-2-induced-ADCC...
  57. ncbi [Tolerance to coxibs in patients with intolerance to non-steroidal anti-inflammatory drugs (NSAIDs)]
    S Boehncke
    Zentrum der Inneren Medizin, Abteilung Endokrinologie
    Dtsch Med Wochenschr 130:2249-52. 2005
    ..We studied tolerability of valdecoxib preferentially inhibitng cyclooxygenase-2 in patients with a history of intolerance to NSAIDs...
  58. ncbi Rituximab treatment in patients with primary Sjögren's syndrome: an open-label phase II study
    J Pijpe
    Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands
    Arthritis Rheum 52:2740-50. 2005
    ....
  59. ncbi High-performance liquid chromatographic-tandem mass spectrometric method for the determination of clemastine in human plasma
    Viola Horvath
    Research Group of Technical Analytical Chemistry, Hungarian Academy of Sciences Budapest University of Technology and Economics, Gellert ter 4, Budapest H 1111, Hungary
    J Chromatogr B Analyt Technol Biomed Life Sci 816:153-9. 2005
    ..liquid chromatographic-tandem mass spectrometric method (HPLC-MS-MS) has been developed to quantitate clemastine in human plasma for the purpose of pharmacokinetic studies...
  60. ncbi Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H1 receptor antagonist clemastine
    Jung Wha Jung
    College of Pharmacy, Sookmyung Women s University, Seoul 140 742, Korea
    Arch Pharm Res 30:1521-5. 2007
    Hydroxyclemastine was targeted as a versatile analogue of clemastine with H1 receptor antagonist activity...
  61. ncbi [Chikungunya: fever and joint pains after vacation in a tropical area]
    G Ahrenstorf
    Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover
    Dtsch Med Wochenschr 133:406-8. 2008
    ..He had a temperature of 38.6 C and painful swellings of both talocalcanean joints...
  62. ncbi Histamine upregulates keratinocyte MMP-9 production via the histamine H1 receptor
    Maria Gschwandtner
    Department of Dermatology, Hannover Medical School, Hannover, Germany
    J Invest Dermatol 128:2783-91. 2008
    ..agonist beta-histine-but not agonists for H(2)R, H(3)R, and H(4)R-induced MMP-9, whereas the H(1)R antagonist clemastine blocked the effect in a dose-dependent manner...
  63. ncbi Interstitial granulomatous dermatitis with arthritis
    Asli Altaykan
    Department of Dermatology, Hacettepe University, Faculty of Medicine, Sihhiye, Ankara, Turkey
    Hum Pathol 35:892-4. 2004
    ..Herein we describe a case of interstitial granulomatous dermatitis with arthritis without the rope sign. The present case supports the idea that interstitial granulomatous dermatitis with arthritis may have variable clinical appearances...
  64. ncbi Clinical pharmacology of clemastine in healthy dogs
    H Hansson
    Department of Small Animal Clinical Sciences, Box 7037, Swedish University of Agricultural Sciences, S 750 07 Uppsala, Sweden
    Vet Dermatol 15:152-8. 2004
    The pharmacokinetic properties of clemastine were investigated in six healthy dogs and compared with the effect of the drug recorded as inhibition of wheal formation induced by intradermal injections of histamine...
  65. ncbi [Severe adverse event following iv administration of 10 ml 6% Dextran60 (0.6 g) in a healthy volunteer]
    G Lehmann
    Institut für Experimentelle Anästhesiologie der Johann Wolfgang Goethe Universität Frankfurt, Germany
    Anaesthesist 51:820-4. 2002
    ..e. 0.6 g) are infused. This is becoming more and more important due to the increasing use of "small volume resuscitation", solutions containing dextran (RescueFlow((R)), Biophausia AB, Uppsala, Schweden) or cryoconservation with dextran...
  66. ncbi [Comparative antihistamine and anti-allergic effects of various antihistamine preparations]
    D G Fridliand
    Ter Arkh 74:67-72. 2002
    ....
  67. ncbi Fexofenadine's effects, alone and with alcohol, on actual driving and psychomotor performance
    A Vermeeren
    Institute for Human Psychopharmacology, Maastricht University, The Netherlands
    J Allergy Clin Immunol 101:306-11. 1998
    ..Fexofenadine is the hydrochloride salt of terfenadine's active metabolite...
  68. ncbi Toxic pustuloderma associated with clemastine therapy
    A Feind-Koopmans
    Department of Dermatology, University Hospital, The Netherlands
    Clin Exp Dermatol 21:293-5. 1996
    ..A case of toxic pustuloderma following treatment with the antihistamine clemastine is now reported.
  69. ncbi The pharmacokinetics and bioavailability of clemastine and phenylpropanolamine in single-component and combination formulations
    H F Schran
    Drug Safety Department, Sandoz Research Institute, New Jersey 07936, USA
    J Clin Pharmacol 36:911-22. 1996
    ..subjects per study) to examine the following: pharmacokinetics and dose proportionality of the antihistamine clemastine; the effect of coadministration of phenylpropanolamine and clemastine on the pharmacokinetics of the two drugs; ..
  70. ncbi The influence of antihistamines on human performance
    A W Gaillard
    TNO Institute for Perception, Soesterberg, The Netherlands
    Eur J Clin Pharmacol 35:249-53. 1988
    ..In Experiment I the subjects were treated orally with loratadine 10 mg, clemastine 1 mg, terfenadine 60 mg, or placebo...
  71. ncbi [Biomimetic oxidation of clemastine hydrogen fumarate]
    L Frohlich
    Institut fur Pharmazie, Humboldt Universitat zu Berlin, Germany
    Pharmazie 51:409-14. 1996
    The reaction of clemastine fumarate (1) with the biomimetic system manganese(III)-5,10,15,20-tetrakis(pentafluoro-water...
  72. ncbi Effects of loratadine on postural control
    T Ledin
    Department of ENT, University Hospital, Linkoping, Sweden
    Acta Otolaryngol Suppl 520:310-2. 1995
    ..Loratadine is a new antihistamine without sedative effects. In this study, loratadine 10 and 40 mg daily, clemastine 2 mg twice daily and placebo were evaluated in 8 healthy subjects in terms of effects on equilibrium as measured ..
  73. ncbi [The irritant effect of dithranol using capillary resistance measurement]
    L Kemeny
    Dermatologische Klinik der Albert Szent Györgyi Medizinischen Universität Szeged
    Z Hautkr 64:34-40. 1989
    ..was prevented or at least reduced, if the patients had previously been treated with either the antihistamine clemastine or the cyclooxygenase-inhibitor indomethacin...
  74. ncbi Pharmacological studies on dithranol-induced irritative dermatitis in mice
    L Kemeny
    Department of Dermatology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Arch Dermatol Res 281:362-5. 1989
    ..The cyclooxygenase inhibitor indomethacin, the antihistamine clemastine, and the anti-oxidant superoxide dismutase also proved to be effective in the reduction of the dermatitis...
  75. ncbi [Anaphylaxis caused by chlorhexidine following cystoscopy or urethral catheterization]
    L E Visser
    Bureau Bijwerkingen Geneesmiddelen, Rijswijk
    Ned Tijdschr Geneeskd 138:778-80. 1994
    ..Although this adverse reaction is probably rare, medical practitioners should be aware of the possibility that a severe anaphylactic reaction may occur during use of these products...
  76. ncbi A comparison of acrivastine versus clemastine and placebo in the treatment of patients with chronic idiopathic urticaria
    F Leyh
    Department of Dermatology and Venereology, Lubeck Klinik, FRG
    J Int Med Res 17:22B-24B. 1989
    ..crossover study to investigate the efficacy of acrivastine at two doses (8 mg and 4 mg) versus 1 mg clemastine and placebo, given three times per day...
  77. ncbi Effects of two antihistamines on chloroquine and histamine induced weal and flare in healthy African volunteers
    B Abila
    Department of Pharmacology, College of Health Sciences, University of Port Harcourt, Nigeria
    Afr J Med Med Sci 23:139-42. 1994
    This study investigated the effects of single doses of clemastine (2mg orally), mepyramine (2 micrograms intradermally) and placebo on weal and flare caused by intradermal chloroquine 2...
  78. ncbi Histamine affects release and biosynthesis of opioid peptides primarily via H1-receptors in bovine chromaffin cells
    M Bommer
    Department of Neuropharmacology, Max Planck Institut fur Psychiatrie, Martinsried, F R G
    J Neurochem 49:1688-96. 1987
    ..changes in peptide cell content, proenkephalin A mRNA levels) are antagonized by the H1-receptor antagonist, clemastine, whereas the H2-receptor antagonists, ranitidine and cimetidine, were less effective (approximately 20% ..
  79. ncbi [Clemastine metabolites in the feces and urine of the rat]
    B Göber
    Sektion Chemie, Humboldt Universitat zu Berlin
    Pharmazie 44:847-51. 1989
    After oral application of clemastine [(1), (+)-2-(2-[1-(4-chlorophenyl)-1-phenylethoxy]-ethyl)-1-methylpyrrol idine- hydrogenfumarate], to rats (200 mg/kg) 18 phase I- and II-metabolites have been detected and isolated from urine and ..
  80. ncbi Comparative two-phase clinicopharmacological trial of a new antihistaminic, EGYT-2062, setastine
    Z Vezekenyi
    First Department of Medicine, University Medical School, Pecs, Hungary
    Acta Med Hung 44:55-64. 1987
    ..A self-controlled blind study was performed. The reference compound was clemastine. Based on the results, for prolonged use a dose of 2 mg three times/day (t.i.d.) is recommended...
  81. ncbi Terfenadine in the treatment of chronic idiopathic urticaria and atopic dermatitis
    N Hjorth
    Department of Dermato venerology, University of Copenhagen, Denmark
    Cutis 42:29-30. 1988
    ..with chronic idiopathic urticaria, terfenadine was found to be as effective as the traditional antihistamine clemastine in reducing the number of wheals and the severity of itch, without causing drowsiness...
  82. ncbi Schedule- and dose-intensified paclitaxel as weekly 1-hour infusion in pretreated solid tumors: results of a phase I/II trial
    T M Löffler
    Städtische Kliniken Dortmund, Department of Medicine, Germany
    Semin Oncol 23:32-4. 1996
    ..Intravenous dexamethasone, cimetidine, clemastine, and ondansetron were administered immediately before the paclitaxel infusion...
  83. ncbi Paclitaxel and simultaneous radiation in locally advanced stage IIIA/B non-small cell lung cancer: a clinical phase I study
    H G Vogt
    Department of Radiation Medicine, Städtische Kliniken Offenbach, Germany
    Semin Oncol 23:120-3. 1996
    ..Paclitaxel was administered as a 3-hour continuous intravenous infusion. Dexamethasone, clemastine, and ranitidine were given for hypersensitivity prophylaxis...
  84. ncbi [Stem cell factor production from cultured nasal epithelial cells--effect on SCF production by drugs]
    Mamoru Koyama
    Department of Otorhinolaryngology, Nippon Medical School, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 105:166-73. 2002
    ..Cyclosporin, prednisolone, fluticasone, ketotifen, and clemastine inhibited SCF production from cultured epithelial cells, but cromoglicate and suplatast did not...
  85. ncbi Evaluation of several solid phase extraction liquid chromatography/tandem mass spectrometry on-line configurations for high-throughput analysis of acidic and basic drugs in rat plasma
    C R Mallet
    Waters Corporations, 34 Maple St, Milford, MA 01757 3696, USA
    Rapid Commun Mass Spectrom 15:1075-83. 2001
    ..The different configurations were tested using an acidic drug (diflunisal) and a basic drug (clemastine) in rat plasma. On-line analysis was performed by injecting 200 microL of diluted plasma...
  86. ncbi High-performance liquid chromatographic-tandem mass spectrometric method for the determination of ethionamide in human plasma, bronchoalveolar lavage fluid and alveolar cells
    J E Conte
    Department of Epidemiology and Biostatistics, University of California, San Francisco, 94117, USA
    J Chromatogr B Biomed Sci Appl 753:343-53. 2001
    ..The retention times for ethionamide, clemastine fumarate (internal standard for plasma), promethazine (internal standard for plasma) and propranolol (internal ..
  87. ncbi Administration of clemastine--H1 histamine receptor blocker in the prevention of haemodynamic disorders after protamine sulfate administration in patients subjected to coronary artery bypass grafting in extracorporeal circulation
    R Lango
    Chair and Department of Anaesthesiology and Intensive Therapy, Medical University, Gdansk, Poland
    Med Sci Monit 6:769-75. 2000
    ..The aim of this study was to examine if clemastine can accelerate the normalisation of arterial blood pressure during the protamine administration after CPB during ..
  88. ncbi Exercise-induced anaphylaxis and urticaria
    A W Nichols
    Department of Community and Family Medicine, University of California, School of Medicine, San Diego
    Clin Sports Med 11:303-12. 1992
    ..Prophylactic treatment includes exercise avoidance, abstention from coprecipitating foods and medications, pretreatment with antihistamines and cromolyn, and the induction of tolerance through regular exercise...
  89. ncbi [Incidence and clinical aspects of scombroid fish poisoning]
    R Maire
    Medizinische Poliklinik, Departement fur Innere Medizin, Universitatsspital Zurich
    Schweiz Med Wochenschr 122:1933-5. 1992
    ..Most patients had erythema (87%), half complained of headache and one third had gastrointestinal symptoms. The clinical course was benign in all patients, and the symptoms had disappeared after a mean period of 8 hours...
  90. ncbi Itch and atopic dermatitis: clinical and experimental studies
    C F Wahlgren
    Department of Dermatology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden
    Acta Derm Venereol Suppl (Stockh) 165:1-53. 1991
    ..randomized, placebo-controlled, cross-over study of 25 AD patients, the effect on clinical itch of a sedative (clemastine) and of a non-sedative (terfenadine) antihistamine did not differ from that of placebo, although both drugs had ..
  91. ncbi [Histamine release and cardiovascular reactions to implantation of bone cement during total hip replacement]
    M Tryba
    Universitätsklinik für Anaesthesiologie, Intensiv und Schmerztherapie Bergmannsheil, Bochum
    Anaesthesist 40:25-32. 1991
    ..In this group, 10 patients were randomly assigned to receive 4 mg clemastine + 400 mg cimetidine i.v. about 15 min before implantation of the bone cement...
  92. ncbi Treatment of hay fever with loratadine--a new non-sedating antihistamine
    K Irander
    Department of Otolaryngology, Faculty of Health Sciences, Linkoping University, Sweden
    Allergy 45:86-91. 1990
    ..sensitive to birch pollen, were randomized into three parallel groups receiving loratadine 40 mg once daily, clemastine 1 mg twice daily, or placebo during the birch pollen season...
  93. ncbi Paclitaxel and carboplatin in the treatment of small-cell lung cancer patients resistant to cyclophosphamide, doxorubicin, and etoposide: a non-cross-resistant schedule
    H J Groen
    Department of Pulmonary Diseases, University Hospital, Groningen, The Netherlands
    J Clin Oncol 17:927-32. 1999
    ..To evaluate the efficacy of paclitaxel and carboplatin (PC) in small-cell lung cancer (SCLC) patients resistant to cyclophosphamide, doxorubicin, and etoposide (CDE)...
  94. ncbi A review and investigation into the mechanistic basis of the genotoxicity of antihistamines
    R D Snyder
    Abbott Laboratories, D 468, AP13 A, 100 Abbott Park Rd, Abbott Park, IL 60064, USA
    Mutat Res 411:235-48. 1998
    ..g. triprolidine, chlorcyclizine, clemastine), possess a dimethylamino substituent suggesting the requirement for this cationic function in the genotoxicity...
  95. ncbi The mechanism of tachykinin-induced bronchoconstriction in the rat
    G F Joos
    Department of Respiratory Diseases, University Hospital, State University of Ghent, Belgium
    Am Rev Respir Dis 137:1038-44. 1988
    ..properties, significantly reduced the bronchoconstriction induced by E, whereas the H1-receptor antagonist clemastine had no effect...
  96. ncbi Effect of antihistamines on interferon production by leukocytes from sensitized and non-sensitized mice
    H Szalaty
    Department of Immunology of Infectious Diseases, Polish Academy of Sciences, Wrocław
    Arch Immunol Ther Exp (Warsz) 36:269-72. 1988
    ..The cells were induced for interferon production with Newcastle virus. It was shown that Tavegyl and Benzhydramine, both after in vivo and in vitro administration, inhibit interferon production, while Intal and Zaditen had no effect...
  97. ncbi Low dose clemastine inhibits sneezing and rhinorrhea during the early nasal allergic reaction
    J H Chung
    Otolaryngology Head and Neck Surgery, Pritzker School of Medicine, University of Chicago, Illinois, USA
    Ann Allergy Asthma Immunol 78:307-12. 1997
    b>Clemastine (1 mg) is currently available over-the-counter for the treatment of allergic rhinitis.
  98. ncbi Inhibition of histamine and allergen skin wheal by cetirizine in four animal species
    C De Vos
    Research Centre, UCB Pharmaceutical Sector, Chemin du Foriest, Belgium
    Ann Allergy 59:278-82. 1987
    ..By the oral route, cetirizine had a more potent and longer acting activity than mepyramine, clemastine, terfenadine, astemizole, and hydroxyzine.
  99. ncbi Identification of urinary metabolites of clemastine after oral administration to man
    M H Choi
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul
    J Pharm Pharmacol 51:53-9. 1999
    The metabolism of clemastine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxylethyl])-1-methylpyrrolidin e, has been studied in three adult male volunteers after a single oral dose of 20 mg as the fumarate...
  100. ncbi IgA pemphigus occurring in a 1-month-old infant
    Masayuki Suzuki
    Department of Dermatology, Jichi Medical School, Yakushiji Minamikawachimachi Kawachigun Tochigi, Japan
    J Am Acad Dermatol 48:S22-4. 2003
    ..Direct immunofluorescence showed IgA deposits in the intercellular space throughout the epidermis. Circulating anti-intercellular IgA autoantibodies were absent. Dapsone therapy was effective...
  101. ncbi Bone cement implantation syndrome. A prospective randomised trial for use of antihistamine blockade
    W R Lamadé
    Department of Surgery, University of Heidelberg, Germany
    Arch Orthop Trauma Surg 114:335-9. 1995
    ..81). Overall, we found even a slight disadvantage for patients receiving antihistamine drugs (statistically not significant). Therefore, histamine-receptor-blocking agents do not have a prophylactic potential in BCIS...

Research Grants2

  1. Novel treatment strategies for enhancing sunitinib response in renal cell cancer
    Towia A Libermann; Fiscal Year: 2013
    ..We demonstrated that three of the highest ranking, FDA-approved candidate drugs, maprotiline, terazosin and clemastine, indeed reverse the sunitinib resistance gene signature in RCC cells, including various genes involved in ..
  2. ARRHYTHMOGENIC ACTIONS OF ANTIHISTAMINES
    Raymond Woosley; Fiscal Year: 1999
    ..first generation antihistamines (cyproheptadine, hydroxyzine, promethazine, chlorpheniramine, phenindamine and clemastine) alone and combined with drugs likely to interact...