Genomes and Genes
Summary: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.
Publications381 found, 100 shown here
- Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitroLan Wu
Department of Geratology, The First Affiliated Hospital, Chinese Medical University, Shenyang, People s Republic of China
Immunopharmacol Immunotoxicol 29:587-96. 2007To elucidate the immunomodulatory mechanisms of macrolides, we investigated here the effects of erythromycin (EM) and its derivatives, 1 and 2, which show no antibacterial activity, on the proliferation and the activation of the ..
- TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modificationMarina Oldenburg
Institute of Medical Microbiology, University of Duisburg Essen, Essen, Germany
Science 337:1111-5. 2012..that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria...
- Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cellsTomoko Suzuki
Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
Am J Respir Crit Care Med 165:1113-8. 2002To examine the effects of erythromycin on rhinovirus (RV) infection in airway epithelium, primary cultures of human tracheal epithelial cells were infected with the RV major subgroup, RV14, and the minor subgroup, RV2...
- Detection of erythromycin-resistant determinants by PCRJ Sutcliffe
Department of Infectious Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
Antimicrob Agents Chemother 40:2562-6. 1996b>Erythromycin resistance determinants include Erm methylases, efflux pumps, and inactivating enzymes...
- Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trialDavid J Serisier
Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
JAMA 309:1260-7. 2013Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined.
- Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural productsR McDaniel
Kosan Biosciences, Inc, 1450 Rollins Road, Burlingame, CA 94010, USA
Proc Natl Acad Sci U S A 96:1846-51. 1999The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains...
- Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology networkL McGee
MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
J Clin Microbiol 39:2565-71. 2001..This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks...
- Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNALorna A Seville
Division of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom
Microb Drug Resist 15:159-66. 2009..from healthy volunteers from six European countries to determine the molecular basis for tetracycline and erythromycin resistance...
- Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338Markiyan Oliynyk
Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
Nat Biotechnol 25:447-53. 2007Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine...
- Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sitesHaitham A Hussain
Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
J Med Microbiol 54:137-41. 2005b>Erythromycin resistance in Clostridium difficile strain 630 is conferred by a genetic element termed Tn5398 which contains two erm(B) genes: erm1(B) and erm2(B)...
- Biosynthesis of complex polyketides in a metabolically engineered strain of E. coliB A Pfeifer
Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5025, USA
Science 291:1790-2. 2001The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional polyketide synthase (..
- Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary diseaseZhi yi He
Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China
Respiration 80:445-52. 2010..Macrolide antibiotics have been shown to exhibit anti-inflammatory effects in some chronic airway inflammatory diseases...
- Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbationsTerence A R Seemungal
Department of Clinical Medical Sciences, St Augustine Campus, University of the West Indies, St Augustine, Trinidad and Tobago
Am J Respir Crit Care Med 178:1139-47. 2008..Macrolides have airway antiinflammatory actions and may reduce the incidence of COPD exacerbations...
- Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genesMagdalena Popowska
Department of Applied Microbiology, Institute of Microbiology, University of Warsaw, Warsaw, Poland
Antimicrob Agents Chemother 56:1434-43. 2012..We analyzed four soils from agricultural systems that were amended with manure from animals treated with erythromycin and exposed to streptomycin and/or oxytetracycline, as well as non-manure-amended compost and forest soil...
- Occurrence, species distribution, antimicrobial resistance and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of domestic animalsFunda A Bagcigil
Department of Microbiology, Istanbul University, 34320 Avcilar, Turkey
Vet Microbiol 121:307-15. 2007..The aim of the study was to investigate the occurrence, species distribution and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of dogs, horses, pigs, and cattle in Denmark...
- Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistanceDaqi Tu
Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
Cell 121:257-70. 2005..marismortui large ribosomal subunits containing the mutation G2099A (A2058 in E. coli) with erythromycin, azithromycin, clindamycin, virginiamycin S, and telithromycin bound explain why eubacterial ribosomes ..
- Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitroN Okazaki
Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratories, Yokohama, Japan
Microbiol Immunol 45:617-20. 2001Some patients with Mycoplasma pneumoniae infection are clinically resistant to antibiotics such as erythromycin, clarithromycin, or clindamycin. We isolated M...
- Persistence of resistance to erythromycin and tetracycline in swine manure during simulated composting and lagoon treatmentsLingling Wang
Department of Animal Sciences, Environmental Science Graduate Program, The Ohio State University, 2027 Coffey Road, Columbus, OH 43210, USA
Microb Ecol 63:32-40. 2012..As determined by selective plate counting, over a 48-day period, cultivated aerobic heterotrophic erythromycin-resistant bacteria and tetracycline-resistant bacteria decreased by more than 4 and 7 logs, respectively, in ..
- Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine productionR G Summers
Antibacterial Discovery Research Division, Abbott Laboratories, Abbott Park, IL 60064, USA
Microbiology 143:3251-62. 1997The nucleotide sequence on both sides of the eryA polyketide synthase genes of the erythromycin-producing bacterium Saccharopolyspora erythraea reveals the presence of ten genes that are involved in L-mycarose (eryB) and D-desosamine (..
- 23S rRNA mutation A2074C conferring high-level macrolide resistance and fitness cost in Campylobacter jejuniHaihong Hao
National Reference Laboratory of Veterinary Drug Residues MOA Key Laboratory of Food Safety Evaluation, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People s Republic of China
Microb Drug Resist 15:239-44. 2009..These findings indicate that the A2074C transversion in C. jejuni is not only correlated with stable and high-level macrolide resistance but also associated with a fitness cost...
- Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombinationJiequn Wu
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Appl Environ Microbiol 77:7508-16. 2011Large-scale production of erythromycin A (Er-A) relies on the organism Saccharopolyspora erythraea, in which lack of a typical attB site largely impedes the application of phage ΦC31 integrase-mediated recombination into site-specific ..
- Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath testK S Lown
Department of Medicine, University of Michigan Medical Center, Ann Arbor 48109 0108
Drug Metab Dispos 22:947-55. 1994..Hepatic levels of CYP3A4 can be estimated by the erythromycin breath test and vary at least 10-fold among patients...
- Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural hostTaradon Luangtongkum
Department of Veterinary Microbiology and Preventive Medicinea, Iowa State University, Ames, Iowa, USA
Antimicrob Agents Chemother 56:1300-8. 2012..jejuni strains, which are either susceptible or resistant to erythromycin (Ery)...
- Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin productionCuauhtemoc Licona-Cassani
Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia
Antonie Van Leeuwenhoek 102:493-502. 2012..Here, we present the metabolic network reconstruction for the erythromycin producer Saccharopolyspora erythraea NRRL23338...
- Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNAS Douthwaite
Department of Molecular Biology, Odense University, DK 5230 Odense M, Denmark
Mol Microbiol 36:183-93. 2000The macrolide antibiotic erythromycin and its 6-O-methyl derivative (clarithromycin) bind to bacterial ribosomes primarily through interactions with nucleotides in domains II and V of 23S rRNA...
- Trends of norfloxacin and erythromycin resistance of Campylobacter jejuni/Campylobacter coli isolates recovered from international travelers, 1994 to 2006Erika R Vlieghe
Department of Clinical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
J Travel Med 15:419-25. 2008..Campylobacter sp. is a major cause of bacterial enterocolitis and travelers' diarrhea. Empiric treatment regimens include fluoroquinolones and macrolides...
- Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolatesXiaoping Xu
Department of Laboratory Medicine, Shenzhen Second People s Hospital, Shenzhen 518035, People s Republic of China
Antimicrob Agents Chemother 54:1152-9. 2010..31% (102/328) of invasive isolates from children in New South Wales, Australia, in 2005 that were resistant to erythromycin. Three serotypes--19F (47 isolates [46%]), 14 (27 isolates [26%]), and 6B (12 isolates [12%])--accounted for 86 ..
- Occurrence of antibiotics in the aquatic environmentR Hirsch
ESWE Institute for Water Research and Water Technology, Wiesbaden, Germany
Sci Total Environ 225:109-18. 1999..The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l...
- Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees CJiqing Guo
Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
Heart Rhythm 2:860-6. 2005Environmental and genetic factors interact to define susceptibility to drug-induced long QT syndrome. Although erythromycin induces long QT syndrome, substantial variability exists with regard to its incidence.
- Receptor for motilin identified in the human gastrointestinal systemS D Feighner
Department of Metabolic Disorders, Department of Medicinal Chemistry, Merck Research Laboratories, Building RY 80Y 265, 126 East Lincoln Avenue, Rahway, NJ 07065, USA
Science 284:2184-8. 1999..The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI ..
- Quinolone-resistant Campylobacter infections: risk factors and clinical consequencesJørgen Engberg
Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
Emerg Infect Dis 10:1056-63. 2004..jejuni infections. An association between treatment with a fluoroquinolone before stool-specimen collection and having a quinolone-resistant C. jejuni infection was not observed...
- Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-κB activity in human macrophages in vitroMeihua Li
Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi 530021, China
Int Immunopharmacol 12:643-50. 2012..molecular mechanism of the inflammatory responses caused by cigarette smoke extract (CSE) and the effects of erythromycin (EM) on CSE-induced HDAC protein expression in human macrophages in vitro...
- Anti-inflammatory activity of macrolide antibioticsA Ianaro
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
J Pharmacol Exp Ther 292:156-63. 2000The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and azithromycin) on the generation of some mediators and cytokines involved in the inflammatory process has been studied both in vivo and in vitro...
- In vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiary-care hospitals in Korea: a nationwide surveyHong Bin Kim
Department of Internal Medicine, College of Medicine, Seoul National University, Seoul 110 744, Republic of Korea
Antimicrob Agents Chemother 48:1124-7. 2004..Rifampin, fusidic acid, trimethoprim-sulfamethoxazole, and arbekacin showed superior in vitro activity compared with the other antibiotics against the MRSA isolates. No isolates showed reduced susceptibility to vancomycin...
- Erythromycin-induced CXCR4 expression on microvascular endothelial cellsYasuyuki Takagi
Dept of Respiratory Medicine, Nagoya Univ Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Am J Physiol Lung Cell Mol Physiol 297:L420-31. 2009..b>Erythromycin (EM), a 14-membered ring macrolide, has an anti-inflammatory effect that may account for its clinical benefit ..
- Erythromycin inhibition of 50S ribosomal subunit formation in Escherichia coli cellsJ Usary
Department of Biochemistry and Molecular Biology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
Mol Microbiol 40:951-62. 2001The effects of erythromycin on the formation of ribosomal subunits were examined in wild-type Escherichia coli cells and in an RNase E mutant strain...
- A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraeaChinping Chng
Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:11346-51. 2008Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific regulatory gene...
- Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trialsEleni Pitsouni
Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
Int J Antimicrob Agents 30:213-21. 2007..The main analysis focused on comparison of azithromycin with erythromycin. In a secondary analysis, azithromycin was compared with erythromycin or amoxicillin...
- Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, ChinaFan Yang
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
Int J Antimicrob Agents 32:386-91. 2008..Non-susceptible rates to penicillin and erythromycin among paediatric isolates (n=122) were 63.1% and 94...
- Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentationYun Chen
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Appl Environ Microbiol 74:1820-8. 2008b>Erythromycin A (Er-A) is the most potent and clinically important member in the Er family produced by Saccharopolyspora erythraea...
- Downregulation of hepatic cytochrome P450 in chronic renal failureF Leblond
Service de Néphrologie et Centre de Recherche Guy Bernier, Hopital Maisonneuve Rosemont, 5415 Boul de l Assomption, Universite de Montreal, Montreal, Quebec H1T 2M4, Canada
J Am Soc Nephrol 12:326-32. 2001..protein expression of several CYP450 isoforms as well as their mRNA, and the in vitro N-demethylation of erythromycin were assessed in liver microsomes...
- Low-dose erythromycin reduces delayed gastric emptying and improves gastric motility after Billroth I pylorus-preserving pancreaticoduodenectomyS Ohwada
Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
Ann Surg 234:668-74. 2001To test the hypothesis that early and low doses of erythromycin reduce the incidence of early delayed gastric emptying (DGE) and induce phase 3 of the migratory motor complex in the stomach after Billroth I pylorus-preserving ..
- A simplified erythromycin resistance cassette for Treponema denticola mutagenesisM Paula Goetting-Minesky
Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
J Microbiol Methods 83:66-8. 2010..denticola. We demonstrate here that ErmB is sufficient for erythromycin selection in T. denticola and that the native ermB promoter drives ErmB expression.
- Prokinetics in acute upper GI bleeding: a meta-analysisAlan N Barkun
Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
Gastrointest Endosc 72:1138-45. 2010..Recent data suggest that administration of prokinetics before gastroscopy may be useful in patients with acute upper GI bleeding (UGIB). Published studies are limited in the number of subjects evaluated, and the conclusions are disparate...
- Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001Irving Nachamkin
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
Emerg Infect Dis 8:1501-3. 2002..jejuni were not observed from 1982 to 1992; however, resistance increased to 40.5% in 2001. Resistance to erythromycin remains at a low level (<5%).
- Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)Jae Hoon Song
Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IL Won Dong, Kangnam Ku, Seoul 135 710, Korea
J Antimicrob Chemother 53:457-63. 2004..To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998-2001...
- High rates of erythromycin and clindamycin resistance among OBGYN isolates of group B StreptococcusLinda P DiPersio
Falor Division of Surgical Research, Summa Health System, Akron, OH 44304, USA
Diagn Microbiol Infect Dis 54:79-82. 2006..isolated during a 4-year period from vaginal/rectal specimens demonstrated a very high resistance rate for both erythromycin (54%) and clindamycin (33%)...
- The effect of erythromycin on video capsule endoscopy intestinal-transit timeGrant R Caddy
Department of Gastroenterology, Ulster Hospital, Dundonald, Belfast, Northern Ireland, United Kingdom
Gastrointest Endosc 63:262-6. 2006..The objective of this study was to determine whether erythromycin increases the completion rate of VCE to the cecum without adversely affecting image quality.
- Persistence of erythromycin-resistant group a streptococci in cultured respiratory cellsCinzia Spinaci
Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University Medical School, Ancona, Italy
Pediatr Infect Dis J 25:880-3. 2006A significant association between erythromycin resistance and ability of bacteria to enter human respiratory cells has been documented in group A streptococci (GAS) isolated in Italy from children with pharyngitis...
- Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopyWai K Leung
Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
World J Gastroenterol 11:4865-8. 2005To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.
- Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolismTakaki Tokairin
Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
Br J Clin Pharmacol 60:172-5. 2005..To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam...
- Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coliSophie Payot
Institut National de la Recherche Agronomique, UR086 BioAgresseurs, santé, Environnement, 37380 Nouzilly, France
Int J Antimicrob Agents 23:468-72. 2004..isolates of Campylobacter coli were studied for their mechanisms of co-resistance to fluoroquinolones and erythromycin. A Thr86Ile modification of GyrA, responsible for fluoroquinolone resistance, was found in all the strains...
- Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin productionAndrew R Reeves
Fermalogic Inc Research and Development, 2201 West Campbell Park Drive, Chicago, IL 60612, US
Metab Eng 9:293-303. 2007..erythraea wild-type strain through duplication of the mmCoA mutase (MCM) operon led to a 50% increase in erythromycin production in a high-performance oil-based fermentation medium. The MCM operon was carried on a 6...
- The effect of erythromycin on the pharmacokinetics of rosuvastatinK J Cooper
AstraZeneca, Alderley Park, Mereside, Macclesfield, Cheshire, SK10 4TG, UK
Eur J Clin Pharmacol 59:51-6. 2003To examine in vivo the effect of erythromycin on the pharmacokinetics of rosuvastatin [an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase]...
- Efficacy of trimethoprim-sulfamethoxazole compared with sulfadoxine-pyrimethamine plus erythromycin for the treatment of uncomplicated malaria in children with integrated management of childhood illness dual classifications of malaria and pneumoniaMary J Hamel
Malaria Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases and the National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Am J Trop Med Hyg 73:609-15. 2005..classifications of malaria and pneumonia, and sulfadoxine-pyrimethyamine (SP) plus five days of treatment with erythromycin (SP plus E) is the recommended second-line treatment...
- Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance geneAndrea Brenciani
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, Via Tronto 10 A, 60020 Ancona, Italy
Antimicrob Agents Chemother 51:1209-16. 2007..pyogenes than currently believed...
- Macrolide-induced digoxin toxicity: a population-based studyT Gomes
The Institute for Clinical Evaluative Sciences, Ontario, Canada
Clin Pharmacol Ther 86:383-6. 2009..8; 95% confidence interval (CI) 7.9-27.9), whereas erythromycin and azithromycin were associated with much lower risk (adjusted OR 3.7; 95% CI 1.7-7.9; and adjusted OR 3...
- Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous hostHaoran Zhang
Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
Chem Biol 17:1232-40. 2010b>Erythromycin A is a potent antibiotic long-recognized as a therapeutic option for bacterial infections...
- Erythromycin modulates eosinophil chemotactic cytokine production by human lung fibroblasts in vitroE Sato
Research Service, Southern Arizona Veterans Health Care System, and the Department of Medicine, University of Arizona, Tucson, Arizona 85723, USA
Antimicrob Agents Chemother 45:401-6. 2001Recent studies suggest that erythromycin can suppress the production of some cytokines and may be an effective treatment for asthma...
- Phenotypes and genotypes of erythromycin-resistant pneumococci in ItalyMaria Pia Montanari
Department of Microbiology and Biomedical Sciences, University of Ancona Medical School, 60131 Ancona, Italy
J Clin Microbiol 41:428-31. 2003Of 120 erythromycin-resistant pneumococci isolated in Italian hospitals, 39 (32.5%) were M-type isolates, carrying the mef gene alone...
- Efficacy of erythromycin for psoriasis vulgarisM Polat
First Dermatology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
Clin Exp Dermatol 32:295-7. 2007..In this study, we investigated the effectiveness of treatment with the macrolide antibiotic, erythromycin, for skin lesions and pruritus of patients with psoriasis...
- Serotype 19f multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South AfricaL McGee
MRC SAIMR Wits Pneumococcal Diseases Research Unit, South African Institute for Medical Research, Johannesburg, South Africa
Antimicrob Agents Chemother 45:1595-8. 2001One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of > or = 0...
- Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in IsraelRan Nir-Paz
Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem, Israel
Int J Antimicrob Agents 28:313-9. 2006..Minimal inhibitory concentrations (MICs) of erythromycin (ERY), clindamycin (CLI) and tetracycline (TET) were determined as well as ERY and TET resistance phenotypes ..
- Effect of erythromycin on image quality and transit time of capsule endoscopy: a two-center studyEva Niv
Department of Gastroenterology, Hillel Yaffe Medical Center, PO Box 169, Hadera 38100, Israel
World J Gastroenterol 14:2561-5. 2008To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology.
- Viridans group streptococci: a reservoir of resistant bacteria in oral cavitiesA Bryskier
Clin Microbiol Infect 8:65-9. 2002The worldwide spread of erythromycin A-resistant streptococci, including Streptococcus pneumoniae, is of concern. Many studies have demonstrated that the viridans group streptococci can be a reservoir of erythromycin A resistance...
- Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agentsAkihiro Sugawara
Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
Bioorg Med Chem Lett 21:3373-6. 2011..In addition, one of its analogues, (8R,9S)-4″,13-O-diacetyl-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A (EM911), was found to be twice as effective as EM900...
- Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducibleKarita D Ambrose
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Antimicrob Agents Chemother 49:4203-9. 2005..Independent deletions were constructed in mefE and mel in the serotype 14 macrolide-resistant strains GA16638 (erythromycin [Em] MIC, 8 to 16 microg/ml) and GA17719 (Em MIC, 2 to 4 microg/ml), which contain allelic variations in the ..
- An investigation of the molecular mechanisms contributing to high-level erythromycin resistance in CampylobacterDeborah Corcoran
Centre for Food Safety, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Ireland
Int J Antimicrob Agents 27:40-5. 2006The molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter jejuni and Campylobacter coli isolates were investigated...
- Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniaeM J Schultz
Laboratory of Experimental Internal Medicine, Department of Intensive Care, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
J Antimicrob Chemother 46:235-40. 2000..Indeed, erythromycin and other macrolides inhibit cytokine production and induce degranulation of neutrophils in vitro...
- Effects of tylosin use on erythromycin resistance in enterococci isolated from swineCharlene R Jackson
United States Department of Agriculture, Agricultural Research Service, Antimicrobial Resistance Research Unit, Richard B Russell Research Center, Athens, GA 30605, USA
Appl Environ Microbiol 70:4205-10. 2004The effect of tylosin on erythromycin-resistant enterococci was examined on three farms; farm A used tylosin for growth promotion, farm B used tylosin for treatment of disease, and farm C did not use tylosin for either growth promotion or ..
- Mechanisms of erythromycin resistance of Campylobacter spp. isolated from food, animals and humansM Kurincic
University of Ljubljana, Biotechnical Faculty, Department of Food Science and Technology, Ljubljana, Slovenia
Int J Food Microbiol 120:186-90. 2007..Campylobacter isolates exhibit two different phenotypes with regard to erythromycin resistance: high-level resistance (HLR) and low-level resistance (LLR)...
- Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysisIoanna N Grivea
University of Patras, School of Medicine, Greece
Antimicrob Agents Chemother 50:256-61. 2006Since the late 1990s, the prevalence of erythromycin-resistant Streptococcus pyogenes has significantly increased in several European countries. Between January 1999 and December 2002, 1,577 isolates of S...
- Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activationMasashi Desaki
Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine Kitasato Medical Institute, Tokyo, Japan
Antimicrob Agents Chemother 48:1581-5. 2004..To elucidate the molecular mechanisms of its action, we studied here the effects of erythromycin (EM) and its new derivative, EM703, which shows no antibacterial action, on the activation of the transcription ..
- Adverse effects of erythromycin on the structure and chemistry of activated sludgeJ N Louvet
Laboratoire des Sciences du Génie Chimique CNRS, Nancy University, INPL, 1, rue Grandville, BP 20451, F 54001 NANCY Cedex, France
Environ Pollut 158:688-93. 2010This study examines the effects of erythromycin on activated sludge from two French urban wastewater treatment plants (WWTPs)...
- Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trialJean Louis Frossard
Division of Gastroenterology and Hepatology, Geneva University Hospitals, Geneve, Switzerland
Gastroenterology 123:17-23. 2002Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying...
- Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibioticsM Gorrini
Clinica di Malattie dell'Apparato Respiratorio, Laboratorio di Biochimica e Genetica, IRCCS Policlinico San Matteo, Via Taramelli 5, 27100 Pavia, Italy
Am J Respir Cell Mol Biol 25:492-9. 2001..we designed a series of spectrophotometric experiments using a chromogenic substrate with two macrolides, erythromycin (Er) and flurythromycin (FE)...
- The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitisA Cervin
School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland, Australia
Acta Otolaryngol 121:83-92. 2001..The aim of this review is to focus on the anti-inflammatory action of erythromycin and its derivatives in the treatment of chronic sinusitis and nasal polyps...
- Molecular mechanism of drug-dependent ribosome stallingNora Vazquez-Laslop
Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, M C 870, Chicago, IL 60607, USA
Mol Cell 30:190-202. 2008Inducible expression of the erm erythromycin resistance genes relies on drug-dependent ribosome stalling. The molecular mechanisms underlying stalling are unknown...
- Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detectionAndrea J Patterson
Gut Health Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
Environ Microbiol 9:703-15. 2007..system was developed to screen environmental samples for the presence of specific tetracycline (Tc(R)) and erythromycin (erm(R)) resistance genes...
- Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007)Emilio Perez-Trallero
Department of Microbiology and CIBERES, Hospital Donostia, San Sebastian, Gipuzkoa, Spain
Antimicrob Agents Chemother 54:2953-9. 2010..Only 0.9% of isolates had a penicillin MIC of > or = 2 microg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a beta-lactamase-positive prevalence of 15...
- Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coliSephorah Zaman
Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
Mol Microbiol 66:1039-50. 2007..To learn more about the roles of the tentacles in ribosome assembly and function, we isolated additional erythromycin-resistant E. coli mutants. Eight new mutations mapped in L4, all within the tentacle...
- Adverse health events associated with antimicrobial drug resistance in Campylobacter species: a registry-based cohort studyMorten Helms
Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark
J Infect Dis 191:1050-5. 2005..Resistance to clinically important antimicrobial agents, particularly fluoroquinolones and macrolides, is increasing among Campylobacter isolates, but few studies have explored the human health consequences of such resistance...
- The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosomeTanel Tenson
Institute of Technology, Tartu University, Riia 23, Tartu 51010, Estonia
J Mol Biol 330:1005-14. 2003..We have studied the mechanisms of action of four macrolides (erythromycin, josamycin, spiramycin and telithromycin), one lincosamide (clindamycin) and one streptogramin B (pristinamycin ..
- Biofilm formation by Streptococcus pneumoniae strains and effects of human serum albumin, ibuprofen, N-acetyl-l-cysteine, amoxicillin, erythromycin, and levofloxacinGema del Prado
Department in Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, 28040 Madrid, Spain
Diagn Microbiol Infect Dis 67:311-8. 2010..Amoxicillin, erythromycin, and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains ..
- Failure of macrolide antibiotic treatment in patients with bacteremia due to erythromycin-resistant Streptococcus pneumoniaeJohn R Lonks
Miriam and Rhode Island Hospitals and Brown Medical School, Providence, RI 02906, USA
Clin Infect Dis 35:556-64. 2002..who had pneumococcal bacteremia and an isolate that was either resistant or intermediately resistant to erythromycin. Controls (n=141) were patients matched for age, sex, location, and year that bacteremia developed who had an ..
- Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cellsY Aoki
Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305, USA
Antimicrob Agents Chemother 43:2678-84. 1999The molecular mechanism of the anti-inflammatory effect of erythromycin (EM) was investigated at the level of transcriptional regulation of cytokine gene expression in T cells...
- Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickensJun Lin
Department of Veterinary Microbiology and Preventive Medicine, 1116 Veterinary Medicine Complex, Iowa State University, Ames, IA 50011, USA
Antimicrob Agents Chemother 51:1678-86. 2007In this work we conducted both in vitro and in vivo experiments to examine the development and mechanisms of erythromycin (Ery) resistance in Campylobacter jejuni and Campylobacter coli...
- Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-kappaB activityWeiping Ren
Department of Orthopaedic Surgery, Wayne State University School of Medicine and the John D Dingle VA Medical Center, 1 South, Hutzel Hospital, 4707 St Antoine Blvd, Detroit, MI 48201, USA
J Orthop Res 22:21-9. 2004..b>Erythromycin (EM), a macrolide antibiotic, has been shown to effectively suppress some types of inflammatory reactions...
- Very early exposure to erythromycin and infantile hypertrophic pyloric stenosisWilliam O Cooper
Department of Pediatrics, Division of General Pediatrics, Vanderbilt University School of Medicine, Suite 5028 MCE, Nashville, TN 37232 8555, USA
Arch Pediatr Adolesc Med 156:647-50. 2002To assess the link between very early erythromycin exposure and pyloric stenosis in young infants.
- Influence of solute carriers on the pharmacokinetics of CYP3A4 probesR M Franke
Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
Clin Pharmacol Ther 84:704-9. 2008..There was no significant correlation between the erythromycin breath test (ERMBT) parameters and midazolam clearance in 30 cancer patients (R(2) < 0...
- Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometryWei hai Xu
State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, The Chinese Academy of Sciences, Guangzhou, Guangzhou 510640, China
Environ Pollut 145:672-9. 2007....
- Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instabilityTodd Wisialowski
Pfizer Global Research and Development, Eastern Point Rd, Building 274, Groton, CT 06340, USA
J Pharmacol Exp Ther 318:352-9. 2006..The purpose of these studies was to compare the assessment for the arrhythmogenic risk of moxifloxacin, erythromycin, and telithromycin...
- RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteineStephanie Tucker
Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Curr Alzheimer Res 3:221-7. 2006..e., paroxetine (SSRI), N-acetyl cysteine (antioxidant), and erythromycin (macrolide antibiotic)) were employed in a pilot study to evaluate their anti-amyloid efficacy in the TgCRND8 ..
- Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequenceAndreas Tauch
Zentrum für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
Plasmid 49:63-74. 2003The complete nucleotide sequence of the erythromycin resistance plasmid pNG2 from the human pathogen Corynebacterium diphtheriae S601 was determined. The plasmid has a total size of 15,100 bp and contains at least 17 coding regions...
- Crystal structure of the erythromycin polyketide synthase dehydrataseAdrian Keatinge-Clay
Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
J Mol Biol 384:941-53. 2008..Here, the structure of a DH domain, isolated from the fourth module of the erythromycin PKS, is presented at 1.85 A resolution...
- Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetesYukinori Tanaka
National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
Appl Environ Microbiol 75:4919-22. 2009..but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental ..
- Is erythromycin therapy teratogenic in humans?Bengt A J Källén
Tornblad Institute, Lund University, Biskospgatan 7, SE 22362 Lund, Sweden
Reprod Toxicol 20:209-14. 2005The possible teratogenic effect of erythromycin therapy, noted previously, was studied...
- Effects of low doses of erythromycin on the 13C Spirulina platensis gastric emptying breath test and electrogastrogram: a controlled study in healthy volunteersJ K DiBaise
Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-2000, USA
Am J Gastroenterol 96:2041-50. 2001..It was our primary objective to examine the effects of low dose i.v. erythromycin on the results of the 13C Spirulina platensis GEBT and electrogastrography...
- Long-term, low-dose erythromycin in bronchiectasis subjects with frequent infective exacerbationsD J Serisier
Dept of Respiratory Medicine, Lvl 9, Mater Adult Hospital, Raymond Tce, South Brisbane, QLD 4101, Australia
Respir Med 105:946-9. 2011..Widespread, injudicious use of long-acting macrolides, particularly azithromycin, risks significantly increasing population antimicrobial resistance...
- Identification of tetracycline- and erythromycin-resistant Gram-positive cocci within the fermenting microflora of an Italian dairy food productC Devirgiliis
INRAN National Research Institute on Food and Nutrition, Via Ardeatina, Rome, Italy
J Appl Microbiol 109:313-23. 2010..Microbiological and molecular analysis of antibiotic resistance in Gram-positive cocci derived from the Italian PDO (Protected Designation of Origin) dairy food product Mozzarella di Bufala Campana...
- New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococciIleana Cochetti
Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, 60020 Ancona, Italy
J Antimicrob Chemother 60:127-31. 2007To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci.
- Structure of the multidrug efflux protein AcrAPartho Ghosh; Fiscal Year: 2006..coli AcrAB-TolC system, which promotes efflux of novobiocin, erythromycin, fusidic acid, tetracycline, and chloramphenicol among others...
- Novel Macrolide Th17 InhibitorsJay K Kolls; Fiscal Year: 2012..A series of macrolide analogs will be synthesized using erythromycin as the starting material...
- Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut PerfusionDavid A Benaron; Fiscal Year: 2012..Aim 3 - To determine the safety of probes used with the T-Stat Perfusion Monitor. ..
- Azithromycin and Sudden Cardiac Death: Electrophysiologic MechanismsKatherine T Murray; Fiscal Year: 2013..The macrolide antibiotics erythromycin and clarithromycin have been linked to life-threatening arrhythmias, while azithromycin is considered to have ..
- MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDSCRAIG CLARKSON; Fiscal Year: 2001..reports strongly suggest that specific antimicrobial drugs used in the treatment of AIDS patients, including erythromycin and pentamidine, also may block HERG encoded K currents...
- Medications and the Risk of Sudden Cardiac DeathWayne A Ray; Fiscal Year: 2013..unexpected, increased risks of sudden cardiac death for several commonly prescribed medications, including oral erythromycin, cyclic antidepressants, and antipsychotics...
- Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK studyRose Viscardi; Fiscal Year: 2009..Trials of antibiotic therapy with erythromycin in the first few weeks of life failed to eradicate respiratory tract colonization and the development of BPD in ..
- Evaluation of Protein Channel-Attenuated Salmonella VaccinesXinghong Yang; Fiscal Year: 2010..Since the channel CFA/I in cell OM allows 741 dalton erythromycin to enter, it will also permit other smaller molecules, such as water, ions, and toxic molecules to pass...
- Azithromycin to prevent BPD in ureaplasma-infected preterms.Ken B Waites; Fiscal Year: 2013..influx and chemoattractant/cytokine release in murine lung injury models (2-4);2) exhibits higher potency than erythromycin against clinical Ureaplasma isolates in vitro (5);and 3) is preferentially concentrated in alveolar epithelial ..
- Disinfectant-resistant mycobacteriaMary Jackson; Fiscal Year: 2013..unusually high levels of resistance to a number of drugs including rifampicin, ciprofloxacin, clarithromycin, erythromycin, vancomycin, tetracycline and linezolid...
- ProstaFluor FDA Trial for Real-Time Margin Detection During ProstatectomyDavid A Benaron; Fiscal Year: 2013..We expect that the market for such a device in cancer could reasonably be in the hundreds of millions of dollars/year. Form SF-424 Abstract ..
- IMPACT OF TUBERCULOSIS ON HIV DISEASEZahra Toossi; Fiscal Year: 2009..HIV transcriptional activation in macrophages may be inhibited by a derivative of erythromycin, EM-703, by modulation of C/EBPβisoforms...
- Biosynthesis of Microbial PolyketidesDavid E Cane; Fiscal Year: 2013..transformations that lead to the formation of complex polyketides, including the macrolide antibiotics erythromycin, methymycin, picromycin, tylosin, and rifamycin, the polyene antifungal agent nystatin, the protein phosphatase ..
- GENETIC ANALYSIS OF RICKETTSIA PROWAZEKIIDavid Wood; Fiscal Year: 2010..will attempt to generate a rickettsial minichromosome by linkingputative origin fragments with the selectable erythromycin-resistant gene, ereB. An alternate method will identify the originby the bindingof rickettsial DnaA...
- A New Approach for Engineering Polyketides by Cytochrome P450 C-H OxidationROBERT VINCENT O'BRIEN; Fiscal Year: 2013..Finally, we will incorporate BioI into module 2 of the nanchangmycin synthase (NANS) and erythromycin synthase (DEBS)...
- ANALYSES OF SITE-SPECIFIC RECOMBINATIONJeffrey F Gardner; Fiscal Year: 2013..It carries genes encoding resistances to the antibiotics tetracycline and erythromycin. CTnDOT also encodes a variety of accessory proteins called Orf2c, Orf2d and Exc that are required for excision...
- High Resolution Analysis of Ribosome-Bound Nascent Polypeptides by NMRSilvia Cavagnero; Fiscal Year: 2009..Several antibiotics acting on the bacterial translation machinery, including erythromycin and telithromycin, act by interfering with the nascent chain progression through the ribosomal exit tunnel...
- IMPACT OF TUBERCULOSIS ON HIV DISEASEZAHRA TOOSSI TOOSSI; Fiscal Year: 2013..These include;1. Derivatives of erythromycin, some of which may be useful in MDR TB, 2. an inhibitor of CDK9 (of P-TEFb), Indirubicin Monoxime, and 3...
- Structural basis of specificity in affinity-labeled polyketide synthase didomainsJanet L Smith; Fiscal Year: 2012..Didomains from the PKS systems for pikromycin, erythromycin, and tylosin will be examined since these molecules are established lead compounds for antibiotic drug ..
- Mechanism of Induction of erm Genes By Ketolide AntibioticsNora Vazquez Laslop; Fiscal Year: 2010..Our preliminary data show that in contrast to erythromycin and macrolides of the second generation, ketolides do not induce ribosome stalling at ermCL...
- NUCLEIC ACID PROBES OF RIBOSOMAL STRUCTURE AND FUNCTIONBARRY COOPERMAN; Fiscal Year: 2003..Many antibiotics in current clinical use, such as tetracycline, erythromycin and other macrolides, neomycin and other aminoglycosides, and chloramphenicol target ribosomes as their sites ..
- SYNTHESIS AND TESTING OF A NEW CLASS OF HEPARINOIDSJoseph Toce; Fiscal Year: 1991..The applicant's company produces large quantities of lactobionic for stabilization of erythromycin and organs for transplant...
- Molecular Analysis of Modular Polyketide SynthasesJanet L Smith; Fiscal Year: 2013..hydrolysis by the terminating thioesterases in the PKSs for pikromycin, erythromycin, tylosin, tautomycetin, curacin, and carmabin. IV...
- Ocular Disposition of Antimicrobial AgentsAshim K Mitra; Fiscal Year: 2010..We also propose to synthesize amino acid, peptide and ascorbate ester prodrugs of erythromycin, levofloxacin and ofloxacin and ascorbate ester prodrugs of ACV, targeted towards the respective transporters ..
- Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniaeDavid S Stephens; Fiscal Year: 2010..Immediately downstream of mefE is an ORF, designated mel, that had significant homology to the erythromycin resistance ATP-binding cassette (ABC) protein, MsrA, of Staphylococcus epidermidis...
- Determining the Architectures and Activities of Polyketide Synthase ModulesADRIAN TRISTAN KEATINGE-CLAY; Fiscal Year: 2013..research is significant as multimodular PKSs produce many important human medicines, such as the antibacterial erythromycin, the antifungal amphotericin, and the anticancer agent epothilone, and through an increased understanding of ..
- A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESISRobert Ross; Fiscal Year: 2000..to treat patients with gastric motor disorders: 1) medication therapy - The prokinetic agents, metoclopramide, erythromycin, cisapride and domperidone, are used to treat these patients...
- Effect of Cirrhosis and Shunts on Drug DispositionStephen Hall; Fiscal Year: 2006..of these individuals to adverse drug reactions and drug-drug interaction by examining the ability of erythromycin to prolong the QT interval and clarithromycin to inhibit metabolism of buspirone, a CYP3A substrate...
- INTERACTION OF ANTIBIOTICS WITH RIBOSOMAL RNAAlexander Mankin; Fiscal Year: 1999..The PI will devote significant effort to understanding a novel mechanism of erythromycin resistance discovered recently in his laboratory...
- Antibiotic Hypersusceptibility Mutations in BacteriaAlexander Mankin; Fiscal Year: 2005..bacterial susceptibility to beta-lactams (ampicillin, ceftazidime, imipenem), translational inhibitors (erythromycin, linezolid, tetracycline, and chloramphenicol) and fluoroquinolone antibiotics (ciprofloxacin)...
- Structure, Mechanism, and Engineering of Assembly Line Polyketide SynthasesChaitan Khosla; Fiscal Year: 2013..Aim 4: Preparation and evaluation of 15-propargyl-erythromycin A analogues: While not directly related to our primary future directions, during the past funding cycle we ..
- MODULATION OF MULTIDRUG RESISTANCE MECHANISMSBranimir Sikic; Fiscal Year: 2002..The effect of different modulators (PSC vs. LY335979) on the erythromycin breath test in patients will be used to dissect the role of cytochrome P450 3A4 in these interactions...
- NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERSChristopher Carreras; Fiscal Year: 2000..We propose to prepare the first member of a new class of acid-stable erythromycin analogs from a novel erythromycin scaffold obtained through genetic engineering of the erythromycin gene ..
- P450 PHENOTYPE AND CHEMOTHERAPY TOXICITY IN THE ELDERLYELIZABETH DEES; Fiscal Year: 2006..In the second phase of the trial, CYP3A4 activity will be measured using the erythromycin breath test (ERMBT), and a novel probe-based assay for CYP2C8 (rosiglitazone) will be pilot tested...
- DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCENEIL DANIELSON; Fiscal Year: 1990..04 pmoles. Pharmaceuticals difficult to detect in the UV such as erythromycin and clindamycin-2-phosphate have been assayed easily at the ppb level...
- Discovery of Novel Macrolide AntibioticsRodrigo B Andrade; Fiscal Year: 2012..Recently, crystal structures of various macrolide drugs (e.g., erythromycin, telithromycin, azithromycin) bound to ribosomal subunits have been solved, offering valuable structural ..
- COMBINATORIAL BIOSYNTHESIS OF MACROLIDE ANTIBIOTICSCHARLES SIH; Fiscal Year: 2001..biosynthesis of the deoxysugars that are present in avermectin (L-oleandrose), doxorubicin (L-daunosamine), an erythromycin A (L-mycarose and D-desosamine)...
- GLOBAL REGULATORS OF SECONDARY METABOLISMAndrew Reeves; Fiscal Year: 2000..An important class of antibiotics which have been in increasing demand are the macrolides. Erythromycin is the most extensively produced of the macrolides, and the producer of erythromycin, Saccharopolyspora ..
- Antibiotic Gene ClustersJ Weber; Fiscal Year: 2001..Actinomycetes is the mycelial, grampositive, Saccharopolyspora erythraea, which has been used to make erythromycin since the mid-1950's...
- Engineering industrial fermentations for renewable amino acid coproductsJ Weber; Fiscal Year: 2009..If successful, the L-lysine produced as a result of this study will be a coproduct of the erythromycin fermentation using Saccharopolyspora erythraea...
- TREATMENT OF ACUTE BRONCHITIS IN PRIMARY CAREDana King; Fiscal Year: 1992..Objectives: The objectives of this project are to: 1. Determine the utility of treatment with erythromycin in primary care patients with acute bronchitis who have no underlying lung disease. 2. Determine if M...
- SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATESMichael Jung; Fiscal Year: 2003..We will also carry out total syntheses of the important antibacterial agents, erythromycin A 3 and oleandomycin 4...
- POTENTIATORS OF BACTERIOSTATIC ANTIBIOTICS IN GRAM +PENELOPE MARKHAM; Fiscal Year: 2000..promising class of compounds, the lead of which, in combination with bacteriostatic concentrations of either erythromycin, chloramphenicol, clindamycin or tetracycline, is synergistically and rapidly bactericidal to S. aureus...
- Features of bacterial ribosomal subunit assembly intermediatesWILLIAM CHAMPNEY; Fiscal Year: 2009..Neomycin and paromomycin will be used to inhibit 30S subunit formation. Erythromycin and azithromycin will be tested for effects on 50S subunit synthesis...
- RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALSPETER BEAL; Fiscal Year: 2003..Antibacterial agents such as neomycin and erythromycin are examples of existing drugs that target sites in bacterial ribosomal RNAs...
- TRANSLATIONAL ATTENUATION AS A GENE REGULATORPAUL LOVETT; Fiscal Year: 1993..Do these result from the fortuitous absence of a Cm stall site? Erythromycin probably stalls ribosomes at a site different from Cm...
- RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALSPETER BEAL; Fiscal Year: 2004..Antibacterial agents such as neomycin and erythromycin are examples of existing drugs that target sites in bacterial ribosomal RNAs...
- Economical Soy-Isoflavone ProductionJ Weber; Fiscal Year: 2001..a source for an isoflavone extract coming from an existing bacterial fermentation used for the production of erythromycin. This fermentation process would generate highly purified isoflavones in large quantities if the producing ..
- ENZYMATIC DETERMINANTS OF ERYTHROMYCIN STEREOCHEMISTRYRichard Summers; Fiscal Year: 2000..applicant's abstract): The proposed research focuses on the biosynthesis of the clinically important antibiotic erythromycin. It is the long-term goal of this project to produce novel erythromycin derivatives that cannot be prepared by ..
- New Ketolide Antibacterial DrugsCharles Hutchinson; Fiscal Year: 2005..Several of the ketolide series of analogs based on 15-R-erythromycin A have excellent in vitro and in vivo antibacterial activity, comparable to or better than the leading ..
- ENGINEERED BIOSYNTHESIS OF NOVEL KETOLIDE ANTIBIOTICSKevin Reynolds; Fiscal Year: 2000..PROPOSED COMMERCIAL APPLICATIONS: Ketolides hold promise as a solution to the increase in erythromycin- resistant bacterial pathogens, including Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus ..
- NOVEL ANTIBIOTICS FROM CYTOSPORAROBERT RONALD; Fiscal Year: 1980..Although there are certain structural similarities with Erythromycin and other macrolides our chemical structure studies have shown that the novel Grahamimycins are a unique new ..
- REGULATION OF ERMC MRNA STABILITYDAVID BECHHOFER; Fiscal Year: 1992..subtilis, which confers erythromycin resistance on the host...
- ANTIBIOTIC REGULATORY GENES AND METABOLIC ENGINEERINGJ Weber; Fiscal Year: 1999..mutations in the Saccharopolyspora erythraea genome, and to find at least one new mutation that affects erythromycin biosynthesis...
- CHARACTERIZATION OF ERYTHROMYCIN RESISTANT CAMPYLOBACTERCaroline Ryan; Fiscal Year: 1991..The mechanisms of resistance will be investigated by examining the binding of labeled erythromycin to ribosomes prepared from sensitive and resistant strains of campylobacter...
- ANTIBIOTIC REGULATORY GENES AND METABOLIC ENGINEERINGAndrew Reeves; Fiscal Year: 2002..This project focuses on strain improvement in a bacterium that generates a widely used antibiotic, erythromycin. This bacterium, Saccharopolyspora erythraea, is a member of the Actinomycete family and is widely used in ..
- Genetic tool to enhance natural product gene expressionIan MacNeil; Fiscal Year: 2005..Specifically, we will measure the expression of erythromycin (a type I PKS) and the calcium-dependent antibiotic (CDA, a NRPS) in the presence and absence of rep...
- GENETIC DESIGNS FOR HIGH-EFFICIENCY MACROLIDE PRODUCTIONJ Weber; Fiscal Year: 1993The macrolides are microbial natural products with many uses in clinical and veterinary medicine. Erythromycin is the best studied example of a macrolide antibiotic; rapamycin and FK506 are promising new immunosuppressant macrolides...
- Specificity of Modular Polyketide SynthasesJEFFREY KITTENDORF; Fiscal Year: 2007..PKS modules, this work will also begin to uncover substrate specificity differences between the pikromycin and erythromycin (DEBS) PKS systems...
- APPROACHES FOR OVERPRODUCTION OF POLYKETIDE ANTIMICRO.Robert McDaniel; Fiscal Year: 2001..In particular, we will target novel erythromycin analogs and cost-saving intermediates for the preparation of the ketolide class of antibiotics which have a ..
- NEW HIGHLY EFFICIENT ROUTES TO POLYKETIDESMICHAEL CALTER; Fiscal Year: 2002..These molecules are widely used in clinical practice, particularly as antibiotics. For example, erythromycin is a complex polyketide that has found wide use as an antibiotic, because of its ability to kill bacteria ..
- SOLID STATE NMR STUDIES OF PEPTIDES AND PROTEINSRobert Griffin; Fiscal Year: 2002..The research will employ innovative isotopic labeling schemes. Complex structures will be characterized with erythromycin/ribosome complex, the ribonucleotide reductase inhibitor complex and characterization of the potential low ..
- A NEW LEWIS ACID CATALYZED CLAISEN REARRANGEMENTDAVID MACMILLAN; Fiscal Year: 2004..with our acyl-Claisen reaction for the highly expeditious synthesis of erythronolide B; a member of the erythromycin antibiotic class...