erythromycin

Summary

Summary: A bacteriostatic antibiotic macrolide produced by Streptomyces erythreus. Erythromycin A is considered its major active component. In sensitive organisms, it inhibits protein synthesis by binding to 50S ribosomal subunits. This binding process inhibits peptidyl transferase activity and interferes with translocation of amino acids during translation and assembly of proteins.

Top Publications

  1. ncbi Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro
    Lan Wu
    Department of Geratology, The First Affiliated Hospital, Chinese Medical University, Shenyang, People s Republic of China
    Immunopharmacol Immunotoxicol 29:587-96. 2007
  2. ncbi TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    Marina Oldenburg
    Institute of Medical Microbiology, University of Duisburg Essen, Essen, Germany
    Science 337:1111-5. 2012
  3. ncbi Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells
    Tomoko Suzuki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 165:1113-8. 2002
  4. pmc Detection of erythromycin-resistant determinants by PCR
    J Sutcliffe
    Department of Infectious Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
    Antimicrob Agents Chemother 40:2562-6. 1996
  5. ncbi Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
    David J Serisier
    Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
    JAMA 309:1260-7. 2013
  6. pmc Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    R McDaniel
    Kosan Biosciences, Inc, 1450 Rollins Road, Burlingame, CA 94010, USA
    Proc Natl Acad Sci U S A 96:1846-51. 1999
  7. pmc Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
    L McGee
    MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
    J Clin Microbiol 39:2565-71. 2001
  8. ncbi Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA
    Lorna A Seville
    Division of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom
    Microb Drug Resist 15:159-66. 2009
  9. ncbi Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
    Markiyan Oliynyk
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nat Biotechnol 25:447-53. 2007
  10. ncbi Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sites
    Haitham A Hussain
    Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Med Microbiol 54:137-41. 2005

Detail Information

Publications381 found, 100 shown here

  1. ncbi Immunomodulatory effects of erythromycin and its derivatives on human T-lymphocyte in vitro
    Lan Wu
    Department of Geratology, The First Affiliated Hospital, Chinese Medical University, Shenyang, People s Republic of China
    Immunopharmacol Immunotoxicol 29:587-96. 2007
    To elucidate the immunomodulatory mechanisms of macrolides, we investigated here the effects of erythromycin (EM) and its derivatives, 1 and 2, which show no antibacterial activity, on the proliferation and the activation of the ..
  2. ncbi TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification
    Marina Oldenburg
    Institute of Medical Microbiology, University of Duisburg Essen, Essen, Germany
    Science 337:1111-5. 2012
    ..that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria...
  3. ncbi Erythromycin inhibits rhinovirus infection in cultured human tracheal epithelial cells
    Tomoko Suzuki
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 165:1113-8. 2002
    To examine the effects of erythromycin on rhinovirus (RV) infection in airway epithelium, primary cultures of human tracheal epithelial cells were infected with the RV major subgroup, RV14, and the minor subgroup, RV2...
  4. pmc Detection of erythromycin-resistant determinants by PCR
    J Sutcliffe
    Department of Infectious Diseases, Pfizer, Inc, Groton, Connecticut 06340, USA
    Antimicrob Agents Chemother 40:2562-6. 1996
    b>Erythromycin resistance determinants include Erm methylases, efflux pumps, and inactivating enzymes...
  5. ncbi Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial
    David J Serisier
    Department of Respiratory Medicine, Level 9, Mater Adult Hospital, Raymond Terr, South Brisbane, Queensland 4101, Australia
    JAMA 309:1260-7. 2013
    Macrolide antibiotics such as erythromycin may improve clinical outcomes in non-cystic fibrosis (CF) bronchiectasis, although associated risks of macrolide resistance are poorly defined.
  6. pmc Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
    R McDaniel
    Kosan Biosciences, Inc, 1450 Rollins Road, Burlingame, CA 94010, USA
    Proc Natl Acad Sci U S A 96:1846-51. 1999
    The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains...
  7. pmc Nomenclature of major antimicrobial-resistant clones of Streptococcus pneumoniae defined by the pneumococcal molecular epidemiology network
    L McGee
    MRC SAIMR Wits Pneumococcal Diseases Research Unit, Johannesburg, South Africa
    J Clin Microbiol 39:2565-71. 2001
    ..This network can serve as a prototype for the collaboration of scientists in identifying clones of important human pathogens and as a model for the development of other networks...
  8. ncbi Distribution of tetracycline and erythromycin resistance genes among human oral and fecal metagenomic DNA
    Lorna A Seville
    Division of Microbial Diseases, UCL Eastman Dental Institute, London, United Kingdom
    Microb Drug Resist 15:159-66. 2009
    ..from healthy volunteers from six European countries to determine the molecular basis for tetracycline and erythromycin resistance...
  9. ncbi Complete genome sequence of the erythromycin-producing bacterium Saccharopolyspora erythraea NRRL23338
    Markiyan Oliynyk
    Department of Biochemistry, University of Cambridge, 80 Tennis Court Road, Cambridge CB2 1GA, UK
    Nat Biotechnol 25:447-53. 2007
    Saccharopolyspora erythraea is used for the industrial-scale production of the antibiotic erythromycin A, derivatives of which play a vital role in medicine...
  10. ncbi Generation of an erythromycin-sensitive derivative of Clostridium difficile strain 630 (630Deltaerm) and demonstration that the conjugative transposon Tn916DeltaE enters the genome of this strain at multiple sites
    Haitham A Hussain
    Division of Microbial Diseases, Eastman Dental Institute for Oral Health Care Sciences, University College London, 256 Gray s Inn Road, London WC1X 8LD, UK
    J Med Microbiol 54:137-41. 2005
    b>Erythromycin resistance in Clostridium difficile strain 630 is conferred by a genetic element termed Tn5398 which contains two erm(B) genes: erm1(B) and erm2(B)...
  11. ncbi Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    B A Pfeifer
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305-5025, USA
    Science 291:1790-2. 2001
    The macrocyclic core of the antibiotic erythromycin, 6-deoxyerythronolide B (6dEB), is a complex natural product synthesized by the soil bacterium Saccharopolyspora erythraea through the action of a multifunctional polyketide synthase (..
  12. ncbi Effect of 6 months of erythromycin treatment on inflammatory cells in induced sputum and exacerbations in chronic obstructive pulmonary disease
    Zhi yi He
    Respiratory Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China
    Respiration 80:445-52. 2010
    ..Macrolide antibiotics have been shown to exhibit anti-inflammatory effects in some chronic airway inflammatory diseases...
  13. ncbi Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations
    Terence A R Seemungal
    Department of Clinical Medical Sciences, St Augustine Campus, University of the West Indies, St Augustine, Trinidad and Tobago
    Am J Respir Crit Care Med 178:1139-47. 2008
    ..Macrolides have airway antiinflammatory actions and may reduce the incidence of COPD exacerbations...
  14. pmc Influence of soil use on prevalence of tetracycline, streptomycin, and erythromycin resistance and associated resistance genes
    Magdalena Popowska
    Department of Applied Microbiology, Institute of Microbiology, University of Warsaw, Warsaw, Poland
    Antimicrob Agents Chemother 56:1434-43. 2012
    ..We analyzed four soils from agricultural systems that were amended with manure from animals treated with erythromycin and exposed to streptomycin and/or oxytetracycline, as well as non-manure-amended compost and forest soil...
  15. ncbi Occurrence, species distribution, antimicrobial resistance and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of domestic animals
    Funda A Bagcigil
    Department of Microbiology, Istanbul University, 34320 Avcilar, Turkey
    Vet Microbiol 121:307-15. 2007
    ..The aim of the study was to investigate the occurrence, species distribution and clonality of methicillin- and erythromycin-resistant staphylococci in the nasal cavity of dogs, horses, pigs, and cattle in Denmark...
  16. ncbi Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
    Daqi Tu
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Cell 121:257-70. 2005
    ..marismortui large ribosomal subunits containing the mutation G2099A (A2058 in E. coli) with erythromycin, azithromycin, clindamycin, virginiamycin S, and telithromycin bound explain why eubacterial ribosomes ..
  17. ncbi Characteristics of macrolide-resistant Mycoplasma pneumoniae strains isolated from patients and induced with erythromycin in vitro
    N Okazaki
    Department of Bacteriology and Pathology, Kanagawa Prefectural Public Health Laboratories, Yokohama, Japan
    Microbiol Immunol 45:617-20. 2001
    Some patients with Mycoplasma pneumoniae infection are clinically resistant to antibiotics such as erythromycin, clarithromycin, or clindamycin. We isolated M...
  18. ncbi Persistence of resistance to erythromycin and tetracycline in swine manure during simulated composting and lagoon treatments
    Lingling Wang
    Department of Animal Sciences, Environmental Science Graduate Program, The Ohio State University, 2027 Coffey Road, Columbus, OH 43210, USA
    Microb Ecol 63:32-40. 2012
    ..As determined by selective plate counting, over a 48-day period, cultivated aerobic heterotrophic erythromycin-resistant bacteria and tetracycline-resistant bacteria decreased by more than 4 and 7 logs, respectively, in ..
  19. ncbi Sequencing and mutagenesis of genes from the erythromycin biosynthetic gene cluster of Saccharopolyspora erythraea that are involved in L-mycarose and D-desosamine production
    R G Summers
    Antibacterial Discovery Research Division, Abbott Laboratories, Abbott Park, IL 60064, USA
    Microbiology 143:3251-62. 1997
    The nucleotide sequence on both sides of the eryA polyketide synthase genes of the erythromycin-producing bacterium Saccharopolyspora erythraea reveals the presence of ten genes that are involved in L-mycarose (eryB) and D-desosamine (..
  20. ncbi 23S rRNA mutation A2074C conferring high-level macrolide resistance and fitness cost in Campylobacter jejuni
    Haihong Hao
    National Reference Laboratory of Veterinary Drug Residues MOA Key Laboratory of Food Safety Evaluation, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, People s Republic of China
    Microb Drug Resist 15:239-44. 2009
    ..These findings indicate that the A2074C transversion in C. jejuni is not only correlated with stable and high-level macrolide resistance but also associated with a fitness cost...
  21. pmc Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination
    Jiequn Wu
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Appl Environ Microbiol 77:7508-16. 2011
    Large-scale production of erythromycin A (Er-A) relies on the organism Saccharopolyspora erythraea, in which lack of a typical attB site largely impedes the application of phage ΦC31 integrase-mediated recombination into site-specific ..
  22. ncbi Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test
    K S Lown
    Department of Medicine, University of Michigan Medical Center, Ann Arbor 48109 0108
    Drug Metab Dispos 22:947-55. 1994
    ..Hepatic levels of CYP3A4 can be estimated by the erythromycin breath test and vary at least 10-fold among patients...
  23. pmc Impaired fitness and transmission of macrolide-resistant Campylobacter jejuni in its natural host
    Taradon Luangtongkum
    Department of Veterinary Microbiology and Preventive Medicinea, Iowa State University, Ames, Iowa, USA
    Antimicrob Agents Chemother 56:1300-8. 2012
    ..jejuni strains, which are either susceptible or resistant to erythromycin (Ery)...
  24. ncbi Reconstruction of the Saccharopolyspora erythraea genome-scale model and its use for enhancing erythromycin production
    Cuauhtemoc Licona-Cassani
    Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Australia
    Antonie Van Leeuwenhoek 102:493-502. 2012
    ..Here, we present the metabolic network reconstruction for the erythromycin producer Saccharopolyspora erythraea NRRL23338...
  25. ncbi Macrolide-ketolide inhibition of MLS-resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
    S Douthwaite
    Department of Molecular Biology, Odense University, DK 5230 Odense M, Denmark
    Mol Microbiol 36:183-93. 2000
    The macrolide antibiotic erythromycin and its 6-O-methyl derivative (clarithromycin) bind to bacterial ribosomes primarily through interactions with nucleotides in domains II and V of 23S rRNA...
  26. ncbi Trends of norfloxacin and erythromycin resistance of Campylobacter jejuni/Campylobacter coli isolates recovered from international travelers, 1994 to 2006
    Erika R Vlieghe
    Department of Clinical Sciences, Prince Leopold Institute of Tropical Medicine, Antwerp, Belgium
    J Travel Med 15:419-25. 2008
    ..Campylobacter sp. is a major cause of bacterial enterocolitis and travelers' diarrhea. Empiric treatment regimens include fluoroquinolones and macrolides...
  27. pmc Distribution of serotypes, genotypes, and resistance determinants among macrolide-resistant Streptococcus pneumoniae isolates
    Xiaoping Xu
    Department of Laboratory Medicine, Shenzhen Second People s Hospital, Shenzhen 518035, People s Republic of China
    Antimicrob Agents Chemother 54:1152-9. 2010
    ..31% (102/328) of invasive isolates from children in New South Wales, Australia, in 2005 that were resistant to erythromycin. Three serotypes--19F (47 isolates [46%]), 14 (27 isolates [26%]), and 6B (12 isolates [12%])--accounted for 86 ..
  28. ncbi Occurrence of antibiotics in the aquatic environment
    R Hirsch
    ESWE Institute for Water Research and Water Technology, Wiesbaden, Germany
    Sci Total Environ 225:109-18. 1999
    ..The investigated STP effluents and surface water samples showed frequent appearance of an erythromycin degradation product, roxithromycin and sulfamethoxazole with concentrations up to 6 micrograms/l...
  29. ncbi Exaggerated block of hERG (KCNH2) and prolongation of action potential duration by erythromycin at temperatures between 37 degrees C and 42 degrees C
    Jiqing Guo
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Heart Rhythm 2:860-6. 2005
    Environmental and genetic factors interact to define susceptibility to drug-induced long QT syndrome. Although erythromycin induces long QT syndrome, substantial variability exists with regard to its incidence.
  30. ncbi Receptor for motilin identified in the human gastrointestinal system
    S D Feighner
    Department of Metabolic Disorders, Department of Medicinal Chemistry, Merck Research Laboratories, Building RY 80Y 265, 126 East Lincoln Avenue, Rahway, NJ 07065, USA
    Science 284:2184-8. 1999
    ..The macrolide antibiotic erythromycin also interacted with the cloned motilin receptor, providing a molecular basis for its effects on the human GI ..
  31. pmc Quinolone-resistant Campylobacter infections: risk factors and clinical consequences
    Jørgen Engberg
    Department of Bacteriology, Mycology and Parasitology, Statens Serum Institut, Copenhagen, Denmark
    Emerg Infect Dis 10:1056-63. 2004
    ..jejuni infections. An association between treatment with a fluoroquinolone before stool-specimen collection and having a quinolone-resistant C. jejuni infection was not observed...
  32. ncbi Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-κB activity in human macrophages in vitro
    Meihua Li
    Department of Respiratory Medicine, The First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi 530021, China
    Int Immunopharmacol 12:643-50. 2012
    ..molecular mechanism of the inflammatory responses caused by cigarette smoke extract (CSE) and the effects of erythromycin (EM) on CSE-induced HDAC protein expression in human macrophages in vitro...
  33. ncbi Anti-inflammatory activity of macrolide antibiotics
    A Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Pharmacol Exp Ther 292:156-63. 2000
    The effect of four macrolide antibiotics (roxithromycin, clarithromycin, erythromycin, and azithromycin) on the generation of some mediators and cytokines involved in the inflammatory process has been studied both in vivo and in vitro...
  34. pmc In vitro activities of 28 antimicrobial agents against Staphylococcus aureus isolates from tertiary-care hospitals in Korea: a nationwide survey
    Hong Bin Kim
    Department of Internal Medicine, College of Medicine, Seoul National University, Seoul 110 744, Republic of Korea
    Antimicrob Agents Chemother 48:1124-7. 2004
    ..Rifampin, fusidic acid, trimethoprim-sulfamethoxazole, and arbekacin showed superior in vitro activity compared with the other antibiotics against the MRSA isolates. No isolates showed reduced susceptibility to vancomycin...
  35. ncbi Erythromycin-induced CXCR4 expression on microvascular endothelial cells
    Yasuyuki Takagi
    Dept of Respiratory Medicine, Nagoya Univ Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Am J Physiol Lung Cell Mol Physiol 297:L420-31. 2009
    ..b>Erythromycin (EM), a 14-membered ring macrolide, has an anti-inflammatory effect that may account for its clinical benefit ..
  36. ncbi Erythromycin inhibition of 50S ribosomal subunit formation in Escherichia coli cells
    J Usary
    Department of Biochemistry and Molecular Biology, J H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Mol Microbiol 40:951-62. 2001
    The effects of erythromycin on the formation of ribosomal subunits were examined in wild-type Escherichia coli cells and in an RNase E mutant strain...
  37. pmc A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea
    Chinping Chng
    Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:11346-51. 2008
    Saccharopolyspora erythraea makes erythromycin, an antibiotic commonly used in human medicine. Unusually, the erythromycin biosynthetic (ery) cluster lacks a pathway-specific regulatory gene...
  38. ncbi Single-dose azithromycin versus erythromycin or amoxicillin for Chlamydia trachomatis infection during pregnancy: a meta-analysis of randomised controlled trials
    Eleni Pitsouni
    Alfa Institute of Biomedical Sciences AIBS, 9 Neapoleos Street, 151 23 Marousi, Athens, Greece
    Int J Antimicrob Agents 30:213-21. 2007
    ..The main analysis focused on comparison of azithromycin with erythromycin. In a secondary analysis, azithromycin was compared with erythromycin or amoxicillin...
  39. ncbi Antimicrobial susceptibility and molecular epidemiology of Streptococcus pneumoniae isolated from Shanghai, China
    Fan Yang
    Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, China
    Int J Antimicrob Agents 32:386-91. 2008
    ..Non-susceptible rates to penicillin and erythromycin among paediatric isolates (n=122) were 63.1% and 94...
  40. pmc Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation
    Yun Chen
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Appl Environ Microbiol 74:1820-8. 2008
    b>Erythromycin A (Er-A) is the most potent and clinically important member in the Er family produced by Saccharopolyspora erythraea...
  41. ncbi Downregulation of hepatic cytochrome P450 in chronic renal failure
    F Leblond
    Service de Néphrologie et Centre de Recherche Guy Bernier, Hopital Maisonneuve Rosemont, 5415 Boul de l Assomption, Universite de Montreal, Montreal, Quebec H1T 2M4, Canada
    J Am Soc Nephrol 12:326-32. 2001
    ..protein expression of several CYP450 isoforms as well as their mRNA, and the in vitro N-demethylation of erythromycin were assessed in liver microsomes...
  42. pmc Low-dose erythromycin reduces delayed gastric emptying and improves gastric motility after Billroth I pylorus-preserving pancreaticoduodenectomy
    S Ohwada
    Second Department of Surgery, Gunma University Faculty of Medicine, Maebashi, Japan
    Ann Surg 234:668-74. 2001
    To test the hypothesis that early and low doses of erythromycin reduce the incidence of early delayed gastric emptying (DGE) and induce phase 3 of the migratory motor complex in the stomach after Billroth I pylorus-preserving ..
  43. pmc A simplified erythromycin resistance cassette for Treponema denticola mutagenesis
    M Paula Goetting-Minesky
    Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, MI 48109 1078, USA
    J Microbiol Methods 83:66-8. 2010
    ..denticola. We demonstrate here that ErmB is sufficient for erythromycin selection in T. denticola and that the native ermB promoter drives ErmB expression.
  44. ncbi Prokinetics in acute upper GI bleeding: a meta-analysis
    Alan N Barkun
    Division of Gastroenterology, McGill University Health Center, McGill University, Montreal, Quebec, Canada
    Gastrointest Endosc 72:1138-45. 2010
    ..Recent data suggest that administration of prokinetics before gastroscopy may be useful in patients with acute upper GI bleeding (UGIB). Published studies are limited in the number of subjects evaluated, and the conclusions are disparate...
  45. pmc Increasing fluoroquinolone resistance in Campylobacter jejuni, Pennsylvania, USA,1982-2001
    Irving Nachamkin
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Emerg Infect Dis 8:1501-3. 2002
    ..jejuni were not observed from 1982 to 1992; however, resistance increased to 40.5% in 2001. Resistance to erythromycin remains at a low level (<5%).
  46. ncbi Macrolide resistance and genotypic characterization of Streptococcus pneumoniae in Asian countries: a study of the Asian Network for Surveillance of Resistant Pathogens (ANSORP)
    Jae Hoon Song
    Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 IL Won Dong, Kangnam Ku, Seoul 135 710, Korea
    J Antimicrob Chemother 53:457-63. 2004
    ..To characterize mechanisms of macrolide resistance among Streptococcus pneumoniae from 10 Asian countries during 1998-2001...
  47. ncbi High rates of erythromycin and clindamycin resistance among OBGYN isolates of group B Streptococcus
    Linda P DiPersio
    Falor Division of Surgical Research, Summa Health System, Akron, OH 44304, USA
    Diagn Microbiol Infect Dis 54:79-82. 2006
    ..isolated during a 4-year period from vaginal/rectal specimens demonstrated a very high resistance rate for both erythromycin (54%) and clindamycin (33%)...
  48. ncbi The effect of erythromycin on video capsule endoscopy intestinal-transit time
    Grant R Caddy
    Department of Gastroenterology, Ulster Hospital, Dundonald, Belfast, Northern Ireland, United Kingdom
    Gastrointest Endosc 63:262-6. 2006
    ..The objective of this study was to determine whether erythromycin increases the completion rate of VCE to the cecum without adversely affecting image quality.
  49. ncbi Persistence of erythromycin-resistant group a streptococci in cultured respiratory cells
    Cinzia Spinaci
    Institute of Microbiology and Biomedical Sciences, Marche Polytechnic University Medical School, Ancona, Italy
    Pediatr Infect Dis J 25:880-3. 2006
    A significant association between erythromycin resistance and ability of bacteria to enter human respiratory cells has been documented in group A streptococci (GAS) isolated in Italy from children with pharyngitis...
  50. ncbi Effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy
    Wai K Leung
    Department of Medicine and Therapeutics, Prince of Wales Hospital, 30 32 Ngan Shing Street, Shatin, Hong Kong, China
    World J Gastroenterol 11:4865-8. 2005
    To determine the effect of oral erythromycin on gastric and small bowel transit time of capsule endoscopy.
  51. pmc Inhibition of the metabolism of brotizolam by erythromycin in humans: in vivo evidence for the involvement of CYP3A4 in brotizolam metabolism
    Takaki Tokairin
    Department of Psychiatry, Yamagata University School of Medicine, Yamagata, Japan
    Br J Clin Pharmacol 60:172-5. 2005
    ..To obtain in vivo evidence for the involvement of cytochrome P450 (CYP) 3A4 in the metabolism of brotizolam...
  52. ncbi Relative contribution of target gene mutation and efflux to fluoroquinolone and erythromycin resistance, in French poultry and pig isolates of Campylobacter coli
    Sophie Payot
    Institut National de la Recherche Agronomique, UR086 BioAgresseurs, santé, Environnement, 37380 Nouzilly, France
    Int J Antimicrob Agents 23:468-72. 2004
    ..isolates of Campylobacter coli were studied for their mechanisms of co-resistance to fluoroquinolones and erythromycin. A Thr86Ile modification of GyrA, responsible for fluoroquinolone resistance, was found in all the strains...
  53. pmc Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production
    Andrew R Reeves
    Fermalogic Inc Research and Development, 2201 West Campbell Park Drive, Chicago, IL 60612, US
    Metab Eng 9:293-303. 2007
    ..erythraea wild-type strain through duplication of the mmCoA mutase (MCM) operon led to a 50% increase in erythromycin production in a high-performance oil-based fermentation medium. The MCM operon was carried on a 6...
  54. ncbi The effect of erythromycin on the pharmacokinetics of rosuvastatin
    K J Cooper
    AstraZeneca, Alderley Park, Mereside, Macclesfield, Cheshire, SK10 4TG, UK
    Eur J Clin Pharmacol 59:51-6. 2003
    To examine in vivo the effect of erythromycin on the pharmacokinetics of rosuvastatin [an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase]...
  55. ncbi Efficacy of trimethoprim-sulfamethoxazole compared with sulfadoxine-pyrimethamine plus erythromycin for the treatment of uncomplicated malaria in children with integrated management of childhood illness dual classifications of malaria and pneumonia
    Mary J Hamel
    Malaria Epidemiology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases and the National Center for HIV, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Am J Trop Med Hyg 73:609-15. 2005
    ..classifications of malaria and pneumonia, and sulfadoxine-pyrimethyamine (SP) plus five days of treatment with erythromycin (SP plus E) is the recommended second-line treatment...
  56. pmc Genetic elements carrying erm(B) in Streptococcus pyogenes and association with tet(M) tetracycline resistance gene
    Andrea Brenciani
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, Via Tronto 10 A, 60020 Ancona, Italy
    Antimicrob Agents Chemother 51:1209-16. 2007
    ..pyogenes than currently believed...
  57. ncbi Macrolide-induced digoxin toxicity: a population-based study
    T Gomes
    The Institute for Clinical Evaluative Sciences, Ontario, Canada
    Clin Pharmacol Ther 86:383-6. 2009
    ..8; 95% confidence interval (CI) 7.9-27.9), whereas erythromycin and azithromycin were associated with much lower risk (adjusted OR 3.7; 95% CI 1.7-7.9; and adjusted OR 3...
  58. ncbi Complete biosynthesis of erythromycin A and designed analogs using E. coli as a heterologous host
    Haoran Zhang
    Department of Chemical and Biological Engineering, Tufts University, Medford, MA 02155, USA
    Chem Biol 17:1232-40. 2010
    b>Erythromycin A is a potent antibiotic long-recognized as a therapeutic option for bacterial infections...
  59. pmc Erythromycin modulates eosinophil chemotactic cytokine production by human lung fibroblasts in vitro
    E Sato
    Research Service, Southern Arizona Veterans Health Care System, and the Department of Medicine, University of Arizona, Tucson, Arizona 85723, USA
    Antimicrob Agents Chemother 45:401-6. 2001
    Recent studies suggest that erythromycin can suppress the production of some cytokines and may be an effective treatment for asthma...
  60. pmc Phenotypes and genotypes of erythromycin-resistant pneumococci in Italy
    Maria Pia Montanari
    Department of Microbiology and Biomedical Sciences, University of Ancona Medical School, 60131 Ancona, Italy
    J Clin Microbiol 41:428-31. 2003
    Of 120 erythromycin-resistant pneumococci isolated in Italian hospitals, 39 (32.5%) were M-type isolates, carrying the mef gene alone...
  61. ncbi Efficacy of erythromycin for psoriasis vulgaris
    M Polat
    First Dermatology Department, Ankara Numune Education and Research Hospital, Ankara, Turkey
    Clin Exp Dermatol 32:295-7. 2007
    ..In this study, we investigated the effectiveness of treatment with the macrolide antibiotic, erythromycin, for skin lesions and pruritus of patients with psoriasis...
  62. pmc Serotype 19f multiresistant pneumococcal clone harboring two erythromycin resistance determinants (erm(B) and mef(A)) in South Africa
    L McGee
    MRC SAIMR Wits Pneumococcal Diseases Research Unit, South African Institute for Medical Research, Johannesburg, South Africa
    Antimicrob Agents Chemother 45:1595-8. 2001
    One hundred eighteen erythromycin-resistant Streptococcus pneumoniae (ERSP) strains (MICs of > or = 0...
  63. ncbi Macrolide, lincosamide and tetracycline susceptibility and emm characterisation of invasive Streptococcus pyogenes isolates in Israel
    Ran Nir-Paz
    Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, P O Box 12000, Jerusalem, Israel
    Int J Antimicrob Agents 28:313-9. 2006
    ..Minimal inhibitory concentrations (MICs) of erythromycin (ERY), clindamycin (CLI) and tetracycline (TET) were determined as well as ERY and TET resistance phenotypes ..
  64. pmc Effect of erythromycin on image quality and transit time of capsule endoscopy: a two-center study
    Eva Niv
    Department of Gastroenterology, Hillel Yaffe Medical Center, PO Box 169, Hadera 38100, Israel
    World J Gastroenterol 14:2561-5. 2008
    To compare the effect of oral erythromycin vs no preparation with prokinetics on the transit time and the image quality of capsule endoscopy (CE) in evaluating small bowel (SB) pathology.
  65. ncbi Viridans group streptococci: a reservoir of resistant bacteria in oral cavities
    A Bryskier
    Clin Microbiol Infect 8:65-9. 2002
    The worldwide spread of erythromycin A-resistant streptococci, including Streptococcus pneumoniae, is of concern. Many studies have demonstrated that the viridans group streptococci can be a reservoir of erythromycin A resistance...
  66. ncbi Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents
    Akihiro Sugawara
    Kitasato Institute for Life Sciences, Kitasato University, and The Kitasato Institute 5 9 1 Shirokane, Minato ku, Tokyo 108 8641, Japan
    Bioorg Med Chem Lett 21:3373-6. 2011
    ..In addition, one of its analogues, (8R,9S)-4″,13-O-diacetyl-8,9-dihydro-6,9-epoxy-8,9-anhydropseudoerythromycin A (EM911), was found to be twice as effective as EM900...
  67. pmc Macrolide efflux in Streptococcus pneumoniae is mediated by a dual efflux pump (mel and mef) and is erythromycin inducible
    Karita D Ambrose
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 49:4203-9. 2005
    ..Independent deletions were constructed in mefE and mel in the serotype 14 macrolide-resistant strains GA16638 (erythromycin [Em] MIC, 8 to 16 microg/ml) and GA17719 (Em MIC, 2 to 4 microg/ml), which contain allelic variations in the ..
  68. ncbi An investigation of the molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter
    Deborah Corcoran
    Centre for Food Safety, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Belfield, Ireland
    Int J Antimicrob Agents 27:40-5. 2006
    The molecular mechanisms contributing to high-level erythromycin resistance in Campylobacter jejuni and Campylobacter coli isolates were investigated...
  69. ncbi Intravenous infusion of erythromycin inhibits CXC chemokine production, but augments neutrophil degranulation in whole blood stimulated with Streptococcus pneumoniae
    M J Schultz
    Laboratory of Experimental Internal Medicine, Department of Intensive Care, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Antimicrob Chemother 46:235-40. 2000
    ..Indeed, erythromycin and other macrolides inhibit cytokine production and induce degranulation of neutrophils in vitro...
  70. pmc Effects of tylosin use on erythromycin resistance in enterococci isolated from swine
    Charlene R Jackson
    United States Department of Agriculture, Agricultural Research Service, Antimicrobial Resistance Research Unit, Richard B Russell Research Center, Athens, GA 30605, USA
    Appl Environ Microbiol 70:4205-10. 2004
    The effect of tylosin on erythromycin-resistant enterococci was examined on three farms; farm A used tylosin for growth promotion, farm B used tylosin for treatment of disease, and farm C did not use tylosin for either growth promotion or ..
  71. ncbi Mechanisms of erythromycin resistance of Campylobacter spp. isolated from food, animals and humans
    M Kurincic
    University of Ljubljana, Biotechnical Faculty, Department of Food Science and Technology, Ljubljana, Slovenia
    Int J Food Microbiol 120:186-90. 2007
    ..Campylobacter isolates exhibit two different phenotypes with regard to erythromycin resistance: high-level resistance (HLR) and low-level resistance (LLR)...
  72. pmc Resistance to erythromycin and telithromycin in Streptococcus pyogenes isolates obtained between 1999 and 2002 from Greek children with tonsillopharyngitis: phenotypic and genotypic analysis
    Ioanna N Grivea
    University of Patras, School of Medicine, Greece
    Antimicrob Agents Chemother 50:256-61. 2006
    Since the late 1990s, the prevalence of erythromycin-resistant Streptococcus pyogenes has significantly increased in several European countries. Between January 1999 and December 2002, 1,577 isolates of S...
  73. pmc Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation
    Masashi Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine Kitasato Medical Institute, Tokyo, Japan
    Antimicrob Agents Chemother 48:1581-5. 2004
    ..To elucidate the molecular mechanisms of its action, we studied here the effects of erythromycin (EM) and its new derivative, EM703, which shows no antibacterial action, on the activation of the transcription ..
  74. ncbi Adverse effects of erythromycin on the structure and chemistry of activated sludge
    J N Louvet
    Laboratoire des Sciences du Génie Chimique CNRS, Nancy University, INPL, 1, rue Grandville, BP 20451, F 54001 NANCY Cedex, France
    Environ Pollut 158:688-93. 2010
    This study examines the effects of erythromycin on activated sludge from two French urban wastewater treatment plants (WWTPs)...
  75. ncbi Erythromycin intravenous bolus infusion in acute upper gastrointestinal bleeding: a randomized, controlled, double-blind trial
    Jean Louis Frossard
    Division of Gastroenterology and Hepatology, Geneva University Hospitals, Geneve, Switzerland
    Gastroenterology 123:17-23. 2002
    Emergency endoscopy may be difficult in upper gastrointestinal bleeding when blood obscures the visibility. Erythromycin, a motilin agonist, induces gastric emptying...
  76. ncbi Inhibition of human neutrophil elastase by erythromycin and flurythromycin, two macrolide antibiotics
    M Gorrini
    Clinica di Malattie dell'Apparato Respiratorio, Laboratorio di Biochimica e Genetica, IRCCS Policlinico San Matteo, Via Taramelli 5, 27100 Pavia, Italy
    Am J Respir Cell Mol Biol 25:492-9. 2001
    ..we designed a series of spectrophotometric experiments using a chromogenic substrate with two macrolides, erythromycin (Er) and flurythromycin (FE)...
  77. ncbi The anti-inflammatory effect of erythromycin and its derivatives, with special reference to nasal polyposis and chronic sinusitis
    A Cervin
    School of Biomolecular and Biomedical Science, Griffith University, Brisbane, Queensland, Australia
    Acta Otolaryngol 121:83-92. 2001
    ..The aim of this review is to focus on the anti-inflammatory action of erythromycin and its derivatives in the treatment of chronic sinusitis and nasal polyps...
  78. ncbi Molecular mechanism of drug-dependent ribosome stalling
    Nora Vazquez-Laslop
    Center for Pharmaceutical Biotechnology, University of Illinois at Chicago, 900 South Ashland Avenue, M C 870, Chicago, IL 60607, USA
    Mol Cell 30:190-202. 2008
    Inducible expression of the erm erythromycin resistance genes relies on drug-dependent ribosome stalling. The molecular mechanisms underlying stalling are unknown...
  79. ncbi Distribution of specific tetracycline and erythromycin resistance genes in environmental samples assessed by macroarray detection
    Andrea J Patterson
    Gut Health Division, Rowett Research Institute, Bucksburn, Aberdeen AB21 9SB, UK
    Environ Microbiol 9:703-15. 2007
    ..system was developed to screen environmental samples for the presence of specific tetracycline (Tc(R)) and erythromycin (erm(R)) resistance genes...
  80. pmc Antimicrobial resistance among respiratory pathogens in Spain: latest data and changes over 11 years (1996-1997 to 2006-2007)
    Emilio Perez-Trallero
    Department of Microbiology and CIBERES, Hospital Donostia, San Sebastian, Gipuzkoa, Spain
    Antimicrob Agents Chemother 54:2953-9. 2010
    ..Only 0.9% of isolates had a penicillin MIC of > or = 2 microg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a beta-lactamase-positive prevalence of 15...
  81. pmc Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli
    Sephorah Zaman
    Department of Biological Sciences, University of Maryland Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Mol Microbiol 66:1039-50. 2007
    ..To learn more about the roles of the tentacles in ribosome assembly and function, we isolated additional erythromycin-resistant E. coli mutants. Eight new mutations mapped in L4, all within the tentacle...
  82. ncbi Adverse health events associated with antimicrobial drug resistance in Campylobacter species: a registry-based cohort study
    Morten Helms
    Department of Epidemiology Research, Danish Epidemiology Science Centre, Copenhagen, Denmark
    J Infect Dis 191:1050-5. 2005
    ..Resistance to clinically important antimicrobial agents, particularly fluoroquinolones and macrolides, is increasing among Campylobacter isolates, but few studies have explored the human health consequences of such resistance...
  83. ncbi The mechanism of action of macrolides, lincosamides and streptogramin B reveals the nascent peptide exit path in the ribosome
    Tanel Tenson
    Institute of Technology, Tartu University, Riia 23, Tartu 51010, Estonia
    J Mol Biol 330:1005-14. 2003
    ..We have studied the mechanisms of action of four macrolides (erythromycin, josamycin, spiramycin and telithromycin), one lincosamide (clindamycin) and one streptogramin B (pristinamycin ..
  84. ncbi Biofilm formation by Streptococcus pneumoniae strains and effects of human serum albumin, ibuprofen, N-acetyl-l-cysteine, amoxicillin, erythromycin, and levofloxacin
    Gema del Prado
    Department in Medical Microbiology and Antimicrobial Chemotherapy, Fundacion Jimenez Diaz Capio, 28040 Madrid, Spain
    Diagn Microbiol Infect Dis 67:311-8. 2010
    ..Amoxicillin, erythromycin, and levofloxacin at supra-MIC concentrations were very active against planktonic cells of 3 selected strains ..
  85. ncbi Failure of macrolide antibiotic treatment in patients with bacteremia due to erythromycin-resistant Streptococcus pneumoniae
    John R Lonks
    Miriam and Rhode Island Hospitals and Brown Medical School, Providence, RI 02906, USA
    Clin Infect Dis 35:556-64. 2002
    ..who had pneumococcal bacteremia and an isolate that was either resistant or intermediately resistant to erythromycin. Controls (n=141) were patients matched for age, sex, location, and year that bacteremia developed who had an ..
  86. pmc Erythromycin inhibits transcriptional activation of NF-kappaB, but not NFAT, through calcineurin-independent signaling in T cells
    Y Aoki
    Division of Pulmonary and Critical Care Medicine, Stanford University Medical Center, Stanford, California 94305, USA
    Antimicrob Agents Chemother 43:2678-84. 1999
    The molecular mechanism of the anti-inflammatory effect of erythromycin (EM) was investigated at the level of transcriptional regulation of cytokine gene expression in T cells...
  87. pmc Effect of macrolide usage on emergence of erythromycin-resistant Campylobacter isolates in chickens
    Jun Lin
    Department of Veterinary Microbiology and Preventive Medicine, 1116 Veterinary Medicine Complex, Iowa State University, Ames, IA 50011, USA
    Antimicrob Agents Chemother 51:1678-86. 2007
    In this work we conducted both in vitro and in vivo experiments to examine the development and mechanisms of erythromycin (Ery) resistance in Campylobacter jejuni and Campylobacter coli...
  88. ncbi Erythromycin inhibits wear debris-induced osteoclastogenesis by modulation of murine macrophage NF-kappaB activity
    Weiping Ren
    Department of Orthopaedic Surgery, Wayne State University School of Medicine and the John D Dingle VA Medical Center, 1 South, Hutzel Hospital, 4707 St Antoine Blvd, Detroit, MI 48201, USA
    J Orthop Res 22:21-9. 2004
    ..b>Erythromycin (EM), a macrolide antibiotic, has been shown to effectively suppress some types of inflammatory reactions...
  89. ncbi Very early exposure to erythromycin and infantile hypertrophic pyloric stenosis
    William O Cooper
    Department of Pediatrics, Division of General Pediatrics, Vanderbilt University School of Medicine, Suite 5028 MCE, Nashville, TN 37232 8555, USA
    Arch Pediatr Adolesc Med 156:647-50. 2002
    To assess the link between very early erythromycin exposure and pyloric stenosis in young infants.
  90. ncbi Influence of solute carriers on the pharmacokinetics of CYP3A4 probes
    R M Franke
    Department of Pharmaceutical Sciences, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Clin Pharmacol Ther 84:704-9. 2008
    ..There was no significant correlation between the erythromycin breath test (ERMBT) parameters and midazolam clearance in 30 cancer patients (R(2) < 0...
  91. ncbi Determination of selected antibiotics in the Victoria Harbour and the Pearl River, South China using high-performance liquid chromatography-electrospray ionization tandem mass spectrometry
    Wei hai Xu
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, The Chinese Academy of Sciences, Guangzhou, Guangzhou 510640, China
    Environ Pollut 145:672-9. 2007
    ....
  92. ncbi Differentiation of arrhythmia risk of the antibacterials moxifloxacin, erythromycin, and telithromycin based on analysis of monophasic action potential duration alternans and cardiac instability
    Todd Wisialowski
    Pfizer Global Research and Development, Eastern Point Rd, Building 274, Groton, CT 06340, USA
    J Pharmacol Exp Ther 318:352-9. 2006
    ..The purpose of these studies was to compare the assessment for the arrhythmogenic risk of moxifloxacin, erythromycin, and telithromycin...
  93. ncbi RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine
    Stephanie Tucker
    Neurochemistry Laboratory, Division of Psychiatric Neurosciences and Genetics and Aging Research Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Alzheimer Res 3:221-7. 2006
    ..e., paroxetine (SSRI), N-acetyl cysteine (antioxidant), and erythromycin (macrolide antibiotic)) were employed in a pilot study to evaluate their anti-amyloid efficacy in the TgCRND8 ..
  94. ncbi Insights into the genetic organization of the Corynebacterium diphtheriae erythromycin resistance plasmid pNG2 deduced from its complete nucleotide sequence
    Andreas Tauch
    Zentrum für Genomforschung, Universitat Bielefeld, Universitatsstrasse 25, D 33615 Bielefeld, Germany
    Plasmid 49:63-74. 2003
    The complete nucleotide sequence of the erythromycin resistance plasmid pNG2 from the human pathogen Corynebacterium diphtheriae S601 was determined. The plasmid has a total size of 15,100 bp and contains at least 17 coding regions...
  95. pmc Crystal structure of the erythromycin polyketide synthase dehydratase
    Adrian Keatinge-Clay
    Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA 94158, USA
    J Mol Biol 384:941-53. 2008
    ..Here, the structure of a DH domain, isolated from the fourth module of the erythromycin PKS, is presented at 1.85 A resolution...
  96. pmc Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes
    Yukinori Tanaka
    National Food Research Institute, 2 1 12 Kannondai, Tsukuba, Ibaraki 305 8642, Japan
    Appl Environ Microbiol 75:4919-22. 2009
    ..but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental ..
  97. ncbi Is erythromycin therapy teratogenic in humans?
    Bengt A J Källén
    Tornblad Institute, Lund University, Biskospgatan 7, SE 22362 Lund, Sweden
    Reprod Toxicol 20:209-14. 2005
    The possible teratogenic effect of erythromycin therapy, noted previously, was studied...
  98. ncbi Effects of low doses of erythromycin on the 13C Spirulina platensis gastric emptying breath test and electrogastrogram: a controlled study in healthy volunteers
    J K DiBaise
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha 68198-2000, USA
    Am J Gastroenterol 96:2041-50. 2001
    ..It was our primary objective to examine the effects of low dose i.v. erythromycin on the results of the 13C Spirulina platensis GEBT and electrogastrography...
  99. ncbi Long-term, low-dose erythromycin in bronchiectasis subjects with frequent infective exacerbations
    D J Serisier
    Dept of Respiratory Medicine, Lvl 9, Mater Adult Hospital, Raymond Tce, South Brisbane, QLD 4101, Australia
    Respir Med 105:946-9. 2011
    ..Widespread, injudicious use of long-acting macrolides, particularly azithromycin, risks significantly increasing population antimicrobial resistance...
  100. ncbi Identification of tetracycline- and erythromycin-resistant Gram-positive cocci within the fermenting microflora of an Italian dairy food product
    C Devirgiliis
    INRAN National Research Institute on Food and Nutrition, Via Ardeatina, Rome, Italy
    J Appl Microbiol 109:313-23. 2010
    ..Microbiological and molecular analysis of antibiotic resistance in Gram-positive cocci derived from the Italian PDO (Protected Designation of Origin) dairy food product Mozzarella di Bufala Campana...
  101. ncbi New Tn916-related elements causing erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci
    Ileana Cochetti
    Institute of Microbiology and Biomedical Sciences, Polytechnic University of Marche Medical School, 60020 Ancona, Italy
    J Antimicrob Chemother 60:127-31. 2007
    To analyse the as yet unexplored genetic elements encoding erm(B)-mediated erythromycin resistance in tetracycline-susceptible pneumococci.

Research Grants63

  1. Structure of the multidrug efflux protein AcrA
    Partho Ghosh; Fiscal Year: 2006
    ..coli AcrAB-TolC system, which promotes efflux of novobiocin, erythromycin, fusidic acid, tetracycline, and chloramphenicol among others...
  2. Novel Macrolide Th17 Inhibitors
    Jay K Kolls; Fiscal Year: 2012
    ..A series of macrolide analogs will be synthesized using erythromycin as the starting material...
  3. Validation in Baboon Model of Broadband NIR Monitoring for Neonate Gut Perfusion
    David A Benaron; Fiscal Year: 2012
    ..Aim 3 - To determine the safety of probes used with the T-Stat Perfusion Monitor. ..
  4. Azithromycin and Sudden Cardiac Death: Electrophysiologic Mechanisms
    Katherine T Murray; Fiscal Year: 2013
    ..The macrolide antibiotics erythromycin and clarithromycin have been linked to life-threatening arrhythmias, while azithromycin is considered to have ..
  5. MOLECULAR BASIS FOR DRUG INDUCED CARDIOTOXICITY IN AIDS
    CRAIG CLARKSON; Fiscal Year: 2001
    ..reports strongly suggest that specific antimicrobial drugs used in the treatment of AIDS patients, including erythromycin and pentamidine, also may block HERG encoded K currents...
  6. Medications and the Risk of Sudden Cardiac Death
    Wayne A Ray; Fiscal Year: 2013
    ..unexpected, increased risks of sudden cardiac death for several commonly prescribed medications, including oral erythromycin, cyclic antidepressants, and antipsychotics...
  7. Azithromycin to prevent BPD in Ureaplasma-infected Preterms: Single Dose PK study
    Rose Viscardi; Fiscal Year: 2009
    ..Trials of antibiotic therapy with erythromycin in the first few weeks of life failed to eradicate respiratory tract colonization and the development of BPD in ..
  8. Evaluation of Protein Channel-Attenuated Salmonella Vaccines
    Xinghong Yang; Fiscal Year: 2010
    ..Since the channel CFA/I in cell OM allows 741 dalton erythromycin to enter, it will also permit other smaller molecules, such as water, ions, and toxic molecules to pass...
  9. Azithromycin to prevent BPD in ureaplasma-infected preterms.
    Ken B Waites; Fiscal Year: 2013
    ..influx and chemoattractant/cytokine release in murine lung injury models (2-4);2) exhibits higher potency than erythromycin against clinical Ureaplasma isolates in vitro (5);and 3) is preferentially concentrated in alveolar epithelial ..
  10. Disinfectant-resistant mycobacteria
    Mary Jackson; Fiscal Year: 2013
    ..unusually high levels of resistance to a number of drugs including rifampicin, ciprofloxacin, clarithromycin, erythromycin, vancomycin, tetracycline and linezolid...
  11. ProstaFluor FDA Trial for Real-Time Margin Detection During Prostatectomy
    David A Benaron; Fiscal Year: 2013
    ..We expect that the market for such a device in cancer could reasonably be in the hundreds of millions of dollars/year. Form SF-424 Abstract ..
  12. IMPACT OF TUBERCULOSIS ON HIV DISEASE
    Zahra Toossi; Fiscal Year: 2009
    ..HIV transcriptional activation in macrophages may be inhibited by a derivative of erythromycin, EM-703, by modulation of C/EBP&#946;&#61472;isoforms...
  13. Biosynthesis of Microbial Polyketides
    David E Cane; Fiscal Year: 2013
    ..transformations that lead to the formation of complex polyketides, including the macrolide antibiotics erythromycin, methymycin, picromycin, tylosin, and rifamycin, the polyene antifungal agent nystatin, the protein phosphatase ..
  14. GENETIC ANALYSIS OF RICKETTSIA PROWAZEKII
    David Wood; Fiscal Year: 2010
    ..will attempt to generate a rickettsial minichromosome by linkingputative origin fragments with the selectable erythromycin-resistant gene, ereB. An alternate method will identify the originby the bindingof rickettsial DnaA...
  15. A New Approach for Engineering Polyketides by Cytochrome P450 C-H Oxidation
    ROBERT VINCENT O'BRIEN; Fiscal Year: 2013
    ..Finally, we will incorporate BioI into module 2 of the nanchangmycin synthase (NANS) and erythromycin synthase (DEBS)...
  16. ANALYSES OF SITE-SPECIFIC RECOMBINATION
    Jeffrey F Gardner; Fiscal Year: 2013
    ..It carries genes encoding resistances to the antibiotics tetracycline and erythromycin. CTnDOT also encodes a variety of accessory proteins called Orf2c, Orf2d and Exc that are required for excision...
  17. High Resolution Analysis of Ribosome-Bound Nascent Polypeptides by NMR
    Silvia Cavagnero; Fiscal Year: 2009
    ..Several antibiotics acting on the bacterial translation machinery, including erythromycin and telithromycin, act by interfering with the nascent chain progression through the ribosomal exit tunnel...
  18. IMPACT OF TUBERCULOSIS ON HIV DISEASE
    ZAHRA TOOSSI TOOSSI; Fiscal Year: 2013
    ..These include;1. Derivatives of erythromycin, some of which may be useful in MDR TB, 2. an inhibitor of CDK9 (of P-TEFb), Indirubicin Monoxime, and 3...
  19. Structural basis of specificity in affinity-labeled polyketide synthase didomains
    Janet L Smith; Fiscal Year: 2012
    ..Didomains from the PKS systems for pikromycin, erythromycin, and tylosin will be examined since these molecules are established lead compounds for antibiotic drug ..
  20. Mechanism of Induction of erm Genes By Ketolide Antibiotics
    Nora Vazquez Laslop; Fiscal Year: 2010
    ..Our preliminary data show that in contrast to erythromycin and macrolides of the second generation, ketolides do not induce ribosome stalling at ermCL...
  21. NUCLEIC ACID PROBES OF RIBOSOMAL STRUCTURE AND FUNCTION
    BARRY COOPERMAN; Fiscal Year: 2003
    ..Many antibiotics in current clinical use, such as tetracycline, erythromycin and other macrolides, neomycin and other aminoglycosides, and chloramphenicol target ribosomes as their sites ..
  22. SYNTHESIS AND TESTING OF A NEW CLASS OF HEPARINOIDS
    Joseph Toce; Fiscal Year: 1991
    ..The applicant's company produces large quantities of lactobionic for stabilization of erythromycin and organs for transplant...
  23. Molecular Analysis of Modular Polyketide Synthases
    Janet L Smith; Fiscal Year: 2013
    ..hydrolysis by the terminating thioesterases in the PKSs for pikromycin, erythromycin, tylosin, tautomycetin, curacin, and carmabin. IV...
  24. Ocular Disposition of Antimicrobial Agents
    Ashim K Mitra; Fiscal Year: 2010
    ..We also propose to synthesize amino acid, peptide and ascorbate ester prodrugs of erythromycin, levofloxacin and ofloxacin and ascorbate ester prodrugs of ACV, targeted towards the respective transporters ..
  25. Molecular bssis of mef-mediated antibiotic resistance in Streptococcus pneumoniae
    David S Stephens; Fiscal Year: 2010
    ..Immediately downstream of mefE is an ORF, designated mel, that had significant homology to the erythromycin resistance ATP-binding cassette (ABC) protein, MsrA, of Staphylococcus epidermidis...
  26. Determining the Architectures and Activities of Polyketide Synthase Modules
    ADRIAN TRISTAN KEATINGE-CLAY; Fiscal Year: 2013
    ..research is significant as multimodular PKSs produce many important human medicines, such as the antibacterial erythromycin, the antifungal amphotericin, and the anticancer agent epothilone, and through an increased understanding of ..
  27. A MULTI-CHANNEL GASTRIC PACER FOR TREATING GASTROPARESIS
    Robert Ross; Fiscal Year: 2000
    ..to treat patients with gastric motor disorders: 1) medication therapy - The prokinetic agents, metoclopramide, erythromycin, cisapride and domperidone, are used to treat these patients...
  28. Effect of Cirrhosis and Shunts on Drug Disposition
    Stephen Hall; Fiscal Year: 2006
    ..of these individuals to adverse drug reactions and drug-drug interaction by examining the ability of erythromycin to prolong the QT interval and clarithromycin to inhibit metabolism of buspirone, a CYP3A substrate...
  29. INTERACTION OF ANTIBIOTICS WITH RIBOSOMAL RNA
    Alexander Mankin; Fiscal Year: 1999
    ..The PI will devote significant effort to understanding a novel mechanism of erythromycin resistance discovered recently in his laboratory...
  30. Antibiotic Hypersusceptibility Mutations in Bacteria
    Alexander Mankin; Fiscal Year: 2005
    ..bacterial susceptibility to beta-lactams (ampicillin, ceftazidime, imipenem), translational inhibitors (erythromycin, linezolid, tetracycline, and chloramphenicol) and fluoroquinolone antibiotics (ciprofloxacin)...
  31. Structure, Mechanism, and Engineering of Assembly Line Polyketide Synthases
    Chaitan Khosla; Fiscal Year: 2013
    ..Aim 4: Preparation and evaluation of 15-propargyl-erythromycin A analogues: While not directly related to our primary future directions, during the past funding cycle we ..
  32. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
    ..The effect of different modulators (PSC vs. LY335979) on the erythromycin breath test in patients will be used to dissect the role of cytochrome P450 3A4 in these interactions...
  33. NOVEL ERYTHROMYCIN ANALOGS FOR GI MOTILITY DISORDERS
    Christopher Carreras; Fiscal Year: 2000
    ..We propose to prepare the first member of a new class of acid-stable erythromycin analogs from a novel erythromycin scaffold obtained through genetic engineering of the erythromycin gene ..
  34. P450 PHENOTYPE AND CHEMOTHERAPY TOXICITY IN THE ELDERLY
    ELIZABETH DEES; Fiscal Year: 2006
    ..In the second phase of the trial, CYP3A4 activity will be measured using the erythromycin breath test (ERMBT), and a novel probe-based assay for CYP2C8 (rosiglitazone) will be pilot tested...
  35. DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCE
    NEIL DANIELSON; Fiscal Year: 1990
    ..04 pmoles. Pharmaceuticals difficult to detect in the UV such as erythromycin and clindamycin-2-phosphate have been assayed easily at the ppb level...
  36. Discovery of Novel Macrolide Antibiotics
    Rodrigo B Andrade; Fiscal Year: 2012
    ..Recently, crystal structures of various macrolide drugs (e.g., erythromycin, telithromycin, azithromycin) bound to ribosomal subunits have been solved, offering valuable structural ..
  37. COMBINATORIAL BIOSYNTHESIS OF MACROLIDE ANTIBIOTICS
    CHARLES SIH; Fiscal Year: 2001
    ..biosynthesis of the deoxysugars that are present in avermectin (L-oleandrose), doxorubicin (L-daunosamine), an erythromycin A (L-mycarose and D-desosamine)...
  38. GLOBAL REGULATORS OF SECONDARY METABOLISM
    Andrew Reeves; Fiscal Year: 2000
    ..An important class of antibiotics which have been in increasing demand are the macrolides. Erythromycin is the most extensively produced of the macrolides, and the producer of erythromycin, Saccharopolyspora ..
  39. Antibiotic Gene Clusters
    J Weber; Fiscal Year: 2001
    ..Actinomycetes is the mycelial, grampositive, Saccharopolyspora erythraea, which has been used to make erythromycin since the mid-1950's...
  40. Engineering industrial fermentations for renewable amino acid coproducts
    J Weber; Fiscal Year: 2009
    ..If successful, the L-lysine produced as a result of this study will be a coproduct of the erythromycin fermentation using Saccharopolyspora erythraea...
  41. TREATMENT OF ACUTE BRONCHITIS IN PRIMARY CARE
    Dana King; Fiscal Year: 1992
    ..Objectives: The objectives of this project are to: 1. Determine the utility of treatment with erythromycin in primary care patients with acute bronchitis who have no underlying lung disease. 2. Determine if M...
  42. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ..We will also carry out total syntheses of the important antibacterial agents, erythromycin A 3 and oleandomycin 4...
  43. POTENTIATORS OF BACTERIOSTATIC ANTIBIOTICS IN GRAM +
    PENELOPE MARKHAM; Fiscal Year: 2000
    ..promising class of compounds, the lead of which, in combination with bacteriostatic concentrations of either erythromycin, chloramphenicol, clindamycin or tetracycline, is synergistically and rapidly bactericidal to S. aureus...
  44. Features of bacterial ribosomal subunit assembly intermediates
    WILLIAM CHAMPNEY; Fiscal Year: 2009
    ..Neomycin and paromomycin will be used to inhibit 30S subunit formation. Erythromycin and azithromycin will be tested for effects on 50S subunit synthesis...
  45. RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALS
    PETER BEAL; Fiscal Year: 2003
    ..Antibacterial agents such as neomycin and erythromycin are examples of existing drugs that target sites in bacterial ribosomal RNAs...
  46. TRANSLATIONAL ATTENUATION AS A GENE REGULATOR
    PAUL LOVETT; Fiscal Year: 1993
    ..Do these result from the fortuitous absence of a Cm stall site? Erythromycin probably stalls ribosomes at a site different from Cm...
  47. RNA-SPECIFIC LIGANDS: AN APPROACH TO NEW ANTIVIRALS
    PETER BEAL; Fiscal Year: 2004
    ..Antibacterial agents such as neomycin and erythromycin are examples of existing drugs that target sites in bacterial ribosomal RNAs...
  48. Economical Soy-Isoflavone Production
    J Weber; Fiscal Year: 2001
    ..a source for an isoflavone extract coming from an existing bacterial fermentation used for the production of erythromycin. This fermentation process would generate highly purified isoflavones in large quantities if the producing ..
  49. ENZYMATIC DETERMINANTS OF ERYTHROMYCIN STEREOCHEMISTRY
    Richard Summers; Fiscal Year: 2000
    ..applicant's abstract): The proposed research focuses on the biosynthesis of the clinically important antibiotic erythromycin. It is the long-term goal of this project to produce novel erythromycin derivatives that cannot be prepared by ..
  50. New Ketolide Antibacterial Drugs
    Charles Hutchinson; Fiscal Year: 2005
    ..Several of the ketolide series of analogs based on 15-R-erythromycin A have excellent in vitro and in vivo antibacterial activity, comparable to or better than the leading ..
  51. ENGINEERED BIOSYNTHESIS OF NOVEL KETOLIDE ANTIBIOTICS
    Kevin Reynolds; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: Ketolides hold promise as a solution to the increase in erythromycin- resistant bacterial pathogens, including Streptococcus pyogenes, Streptococcus pneumoniae, Staphylococcus ..
  52. NOVEL ANTIBIOTICS FROM CYTOSPORA
    ROBERT RONALD; Fiscal Year: 1980
    ..Although there are certain structural similarities with Erythromycin and other macrolides our chemical structure studies have shown that the novel Grahamimycins are a unique new ..
  53. REGULATION OF ERMC MRNA STABILITY
    DAVID BECHHOFER; Fiscal Year: 1992
    ..subtilis, which confers erythromycin resistance on the host...
  54. ANTIBIOTIC REGULATORY GENES AND METABOLIC ENGINEERING
    J Weber; Fiscal Year: 1999
    ..mutations in the Saccharopolyspora erythraea genome, and to find at least one new mutation that affects erythromycin biosynthesis...
  55. CHARACTERIZATION OF ERYTHROMYCIN RESISTANT CAMPYLOBACTER
    Caroline Ryan; Fiscal Year: 1991
    ..The mechanisms of resistance will be investigated by examining the binding of labeled erythromycin to ribosomes prepared from sensitive and resistant strains of campylobacter...
  56. ANTIBIOTIC REGULATORY GENES AND METABOLIC ENGINEERING
    Andrew Reeves; Fiscal Year: 2002
    ..This project focuses on strain improvement in a bacterium that generates a widely used antibiotic, erythromycin. This bacterium, Saccharopolyspora erythraea, is a member of the Actinomycete family and is widely used in ..
  57. Genetic tool to enhance natural product gene expression
    Ian MacNeil; Fiscal Year: 2005
    ..Specifically, we will measure the expression of erythromycin (a type I PKS) and the calcium-dependent antibiotic (CDA, a NRPS) in the presence and absence of rep...
  58. GENETIC DESIGNS FOR HIGH-EFFICIENCY MACROLIDE PRODUCTION
    J Weber; Fiscal Year: 1993
    The macrolides are microbial natural products with many uses in clinical and veterinary medicine. Erythromycin is the best studied example of a macrolide antibiotic; rapamycin and FK506 are promising new immunosuppressant macrolides...
  59. Specificity of Modular Polyketide Synthases
    JEFFREY KITTENDORF; Fiscal Year: 2007
    ..PKS modules, this work will also begin to uncover substrate specificity differences between the pikromycin and erythromycin (DEBS) PKS systems...
  60. APPROACHES FOR OVERPRODUCTION OF POLYKETIDE ANTIMICRO.
    Robert McDaniel; Fiscal Year: 2001
    ..In particular, we will target novel erythromycin analogs and cost-saving intermediates for the preparation of the ketolide class of antibiotics which have a ..
  61. NEW HIGHLY EFFICIENT ROUTES TO POLYKETIDES
    MICHAEL CALTER; Fiscal Year: 2002
    ..These molecules are widely used in clinical practice, particularly as antibiotics. For example, erythromycin is a complex polyketide that has found wide use as an antibiotic, because of its ability to kill bacteria ..
  62. SOLID STATE NMR STUDIES OF PEPTIDES AND PROTEINS
    Robert Griffin; Fiscal Year: 2002
    ..The research will employ innovative isotopic labeling schemes. Complex structures will be characterized with erythromycin/ribosome complex, the ribonucleotide reductase inhibitor complex and characterization of the potential low ..
  63. A NEW LEWIS ACID CATALYZED CLAISEN REARRANGEMENT
    DAVID MACMILLAN; Fiscal Year: 2004
    ..with our acyl-Claisen reaction for the highly expeditious synthesis of erythronolide B; a member of the erythromycin antibiotic class...