4 butyrolactone

Summary

Summary: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.

Top Publications

  1. ncbi Listening in on bacteria: acyl-homoserine lactone signalling
    Clay Fuqua
    Department of Biology, Indiana University, Jordan Hall 142, 1001 East 3rd Street, Bloomington, Indiana 47405, USA
    Nat Rev Mol Cell Biol 3:685-95. 2002
  2. ncbi The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
    S Schauder
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Microbiol 41:463-76. 2001
  3. pmc Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
    J P Pearson
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    J Bacteriol 181:1203-10. 1999
  4. ncbi Response of Arabidopsis thaliana to N-hexanoyl-DL-homoserine-lactone, a bacterial quorum sensing molecule produced in the rhizosphere
    Uta von Rad
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764, Munich Neuherberg, Germany
    Planta 229:73-85. 2008
  5. pmc Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis
    Sang Jun Lee
    R and D Center, inBioNET Corporation, Daejeon 305 390, Korea
    Appl Environ Microbiol 68:3919-24. 2002
  6. pmc Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi
    Jennifer M Henke
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 186:6902-14. 2004
  7. pmc Reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein
    M L Urbanowski
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:631-7. 2004
  8. ncbi Quorum sensing in the genus Burkholderia
    Leo Eberl
    Department of Microbiology, Institute of Plant Biology, University Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Int J Med Microbiol 296:103-10. 2006
  9. pmc Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1
    Jean J Huang
    Department of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Appl Environ Microbiol 69:5941-9. 2003
  10. ncbi Quorum sensing in the Burkholderia cepacia complex
    Vittorio Venturi
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Res Microbiol 155:238-44. 2004

Research Grants

  1. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
  2. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
  3. OLFACTORY NEURONS: A MODEL FOR NEUROTROPHIN FUNCTION
    Gabriele Ronnett; Fiscal Year: 2004
  4. Fatty Acid Synthase Inhibition and Neuronal Metabolism
    Gabriele Ronnett; Fiscal Year: 2005
  5. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
  6. CNS Fatty Acid Metabolism in Regulation of Food Intake
    Susan Aja; Fiscal Year: 2007
  7. Endogenous Estrogens and Colorectal Cancer Risk in Women
    Anne Zeleniuch Jacquotte; Fiscal Year: 2007
  8. Estrogen Metabolism Related Genes & Endometrial Cancer
    Anne Zeleniuch Jacquotte; Fiscal Year: 2007
  9. Olfactory Neurons--Model for PACAP Neurotrophic Function
    Gabriele Ronnett; Fiscal Year: 2005
  10. STUDIES OF FAS INHIBITION IN HUMAN BREAST CANCER CELLS
    FRANCIS KUHAJDA; Fiscal Year: 2003

Detail Information

Publications210 found, 100 shown here

  1. ncbi Listening in on bacteria: acyl-homoserine lactone signalling
    Clay Fuqua
    Department of Biology, Indiana University, Jordan Hall 142, 1001 East 3rd Street, Bloomington, Indiana 47405, USA
    Nat Rev Mol Cell Biol 3:685-95. 2002
    ..Bacterial intercellular communication has become a target for the development of new anti-virulence drugs...
  2. ncbi The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
    S Schauder
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Microbiol 41:463-76. 2001
    ..This result suggests that, unlike quorum sensing via the family of related homoserine lactone autoinducers, AI-2 is a unique, 'universal' signal that could be used by a variety of bacteria for communication among and between species...
  3. pmc Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals
    J P Pearson
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York 14642, USA
    J Bacteriol 181:1203-10. 1999
    ..Apparently the length and/or degree of substitution of the N-acyl side chain determines whether an AI is freely diffusible or is subject to active efflux by P. aeruginosa...
  4. ncbi Response of Arabidopsis thaliana to N-hexanoyl-DL-homoserine-lactone, a bacterial quorum sensing molecule produced in the rhizosphere
    Uta von Rad
    Institute of Biochemical Plant Pathology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764, Munich Neuherberg, Germany
    Planta 229:73-85. 2008
    ..In sum, the bacterial quorum sensing signal C6-HSL does induce transcriptional changes in Arabidopsis and may contribute to tuning plant growth to the microbial composition of the rhizosphere...
  5. pmc Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis
    Sang Jun Lee
    R and D Center, inBioNET Corporation, Daejeon 305 390, Korea
    Appl Environ Microbiol 68:3919-24. 2002
    ..These results indicate that insecticidal B. thuringiensis strains might have potential to compete with gram-negative bacteria in natural ecosystems by autoinducer-degrading activity...
  6. pmc Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi
    Jennifer M Henke
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 186:6902-14. 2004
    ..Together these communication systems act as a three-way coincidence detector in the regulation of a variety of genes, including those responsible for bioluminescence, type III secretion, and metalloprotease production...
  7. pmc Reversible acyl-homoserine lactone binding to purified Vibrio fischeri LuxR protein
    M L Urbanowski
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 186:631-7. 2004
    ..The differences have implications for the ways in which these proteins respond to decreases in signal concentrations or rapid drops in population density...
  8. ncbi Quorum sensing in the genus Burkholderia
    Leo Eberl
    Department of Microbiology, Institute of Plant Biology, University Zurich, Zollikerstrasse 107, Ch 8008 Zurich, Switzerland
    Int J Med Microbiol 296:103-10. 2006
    ..Given the essential role of QS in the expression of pathogenic traits in Burkholderia these regulatory systems represent attractive targets for the development of novel therapeutics...
  9. pmc Utilization of acyl-homoserine lactone quorum signals for growth by a soil pseudomonad and Pseudomonas aeruginosa PAO1
    Jean J Huang
    Department of Biology, California Institute of Technology, Pasadena, California 91125, USA
    Appl Environ Microbiol 69:5941-9. 2003
    ....
  10. ncbi Quorum sensing in the Burkholderia cepacia complex
    Vittorio Venturi
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Res Microbiol 155:238-44. 2004
    ..In the last four years HSL-dependent quorum sensing has been identified in members of the Burkholderia cepacia complex, and this mini-review summarizes initial findings and discusses future perspectives...
  11. ncbi Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex
    A Gotschlich
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Germany
    Syst Appl Microbiol 24:1-14. 2001
    ....
  12. ncbi A bacterial hormone (the SCB1) directly controls the expression of a pathway-specific regulatory gene in the cryptic type I polyketide biosynthetic gene cluster of Streptomyces coelicolor
    Eriko Takano
    Mikrobiologie Biotechnologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Mol Microbiol 56:465-79. 2005
    ..This is the first report with comprehensive in vivo and in vitro data to show that a gamma-butyrolactone-binding protein directly regulates a secondary metabolite pathway-specific regulatory gene in Streptomyces...
  13. pmc Long-chain acyl-homoserine lactone quorum-sensing regulation of Rhodobacter capsulatus gene transfer agent production
    Amy L Schaefer
    Department of Microbiology and W M Keck Foundation Microbial Communities and Cell Signaling Laboratory, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 184:6515-21. 2002
    ..Thus, long-chain acyl-homoserine lactones serve as quorum-sensing signals to enhance genetic exchange in R. capsulatus...
  14. ncbi Novel bacteria degrading N-acylhomoserine lactones and their use as quenchers of quorum-sensing-regulated functions of plant-pathogenic bacteria
    Stephane Uroz
    Interactions Plantes et Micro organismes de la Rhizosphère, Institut des Sciences du Vegetal, CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    Microbiology 149:1981-9. 2003
    ..These series of results reveal the diversity of the QS-interfering bacteria in the rhizosphere and demonstrate the validity of targeting QS signal molecules to control pathogens with natural bacterial isolates...
  15. pmc Microarray analysis of Pseudomonas aeruginosa quorum-sensing regulons: effects of growth phase and environment
    Victoria E Wagner
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    J Bacteriol 185:2080-95. 2003
    ..Importantly, 222 genes were identified as being QS repressed. Environmental factors, such as medium composition and oxygen availability, eliminated detection of transcripts of many genes that were identified as being QS regulated...
  16. ncbi Induction and inhibition of Pseudomonas aeruginosa quorum sensing by synthetic autoinducer analogs
    Kristina M Smith
    Department of Biological Sciences, University at Buffalo, State University of New York, 14260, USA
    Chem Biol 10:81-9. 2003
    ..We performed a series of assays to show that inhibition of quorum sensing by these antagonists significantly reduced the production of virulence factors and biofilm formation...
  17. ncbi Cooperation of two distinct ExpR regulators controls quorum sensing specificity and virulence in the plant pathogen Erwinia carotovora
    Solveig Sjöblom
    Viikki Biocenter, Faculty of Biosciences, Department of Biological and Environmental Sciences, Division of Genetics, University of Helsinki, P O B 56, FIN 00014, Helsinki, Finland
    Mol Microbiol 60:1474-89. 2006
    ..These results suggest that Ecc is able to react both to the cognate AHSL signal and the signals produced by other bacterial species...
  18. pmc Distribution of quorum-sensing genes in the Burkholderia cepacia complex
    E Lutter
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, Calgary, Alberta, Canada T2N 4N1
    Infect Immun 69:4661-6. 2001
    ..bviIR were amplified from B. vietnamiensis. All genomovars produced N-octanoyl-L-homoserine lactone and N-hexanoyl-L-homoserine lactone. B. vietnamiensis and B. cepacia genomovar VII produced additional N-acyl-L-homoserine lactones...
  19. ncbi Induction of systemic resistance in tomato by N-acyl-L-homoserine lactone-producing rhizosphere bacteria
    Regina Schuhegger
    Institute of Biochemical Plant Pathology, GSF National Research Center for Environment and Health, Ingolstadter Landstr 1, D 85764 Neuherberg, Germany
    Plant Cell Environ 29:909-18. 2006
    ..e. PR1a, 26 kDa acidic and 30 kDa basic chitinase). Together, these data support the view that AHL molecules play a role in the biocontrol activity of rhizobacteria through the induction of systemic resistance to pathogens...
  20. pmc Characterization of the Sinorhizobium meliloti sinR/sinI locus and the production of novel N-acyl homoserine lactones
    Melanie M Marketon
    Department of Molecular and Cell Biology, University of Texas at Dallas, Richardson, Texas 75083 0688, USA
    J Bacteriol 184:5686-95. 2002
    ..We believe that these short-chain AHLs are evidence of a second quorum-sensing system in Rm1021, which we refer to here as the mel system, for "S. meliloti."..
  21. ncbi Gamma-butyrolactones: Streptomyces signalling molecules regulating antibiotic production and differentiation
    Eriko Takano
    Mikrobiologie Biotechnologie, Eberhard Karls Universitat Tubingen, Elfriede Aulhorn Str 6, 72076 Tubingen, Germany
    Curr Opin Microbiol 9:287-94. 2006
    ..The importance of understanding how secondary metabolites are regulated and how environmental and physiological signals are sensed highlights the relevance of studying this system...
  22. pmc Quorum sensing regulates type III secretion in Vibrio harveyi and Vibrio parahaemolyticus
    Jennifer M Henke
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Bacteriol 186:3794-805. 2004
    ..Surprisingly, we find that at high cell density (in the presence of autoinducers), quorum sensing represses TTS in V. harveyi and V. parahaemolyticus...
  23. pmc Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria
    Grant D Geske
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, WI 53706 1322, USA
    Chem Soc Rev 37:1432-47. 2008
    ....
  24. ncbi Library screening for synthetic agonists and antagonists of a Pseudomonas aeruginosa autoinducer
    Kristina M Smith
    Department of Biological Sciences, State University of New York, Buffalo, Buffalo, NY 14260, USA
    Chem Biol 10:563-71. 2003
    ..A representative antagonist was further tested for its ability to inhibit virulence factors. This data progresses our understanding of the LasR-AI interaction toward the rational design of therapeutic inhibitors of QS...
  25. ncbi N-acyl-L-homoserine lactone signal interception by Escherichia coli
    Rob Van Houdt
    Laboratory of Food Microbiology, Katholieke Universiteit Leuven, Leuven, Belgium
    FEMS Microbiol Lett 256:83-9. 2006
    ..In conclusion, our work shows that E. coli has the capacity to alter its pattern of gene expression and its phenotypical properties in response to AHLs by means of the AHL responsive transcriptional regulator SdiA...
  26. ncbi Quorum sensing: the many languages of bacteria
    Nicola C Reading
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    FEMS Microbiol Lett 254:1-11. 2006
    ..Three major quorum-sensing circuits have been described: one used primarily by Gram-negative bacteria, one used primarily by Gram-positive bacteria, and one that has been proposed to be universal...
  27. ncbi Diversity of N-acyl homoserine lactone-producing and -degrading bacteria in soil and tobacco rhizosphere
    Cathy D'Angelo-Picard
    Centre National de la Recherche Scientifique, Institut des Sciences du Vegetal, F 91198, Gif sur Yvette, France
    Environ Microbiol 7:1796-808. 2005
    ....
  28. ncbi The Pseudomonas aeruginosa quinolone signal molecule overcomes the cell density-dependency of the quorum sensing hierarchy, regulates rhl-dependent genes at the onset of stationary phase and can be produced in the absence of LasR
    Stephen P Diggle
    Institute of Infection, Immunity and Inflammation, University of Nottingham, Queen s Medical Centre, Nottingham NG7 2RD, UK
    Mol Microbiol 50:29-43. 2003
    ..Increased expression of lecA in the presence of exogenous PQS can be explained partially by increases in RhlR, RpoS and C4-HSL levels. A refined model for quorum sensing in P. aeruginosa is presented...
  29. ncbi Chemical identification of N-acyl homoserine lactone quorum-sensing signals produced by Sinorhizobium meliloti strains in defined medium
    Max Teplitski
    Department of Horticulture and Crop Science, Ohio State University, 2021 Coffey Rd, Columbus, OH 43210, USA
    Arch Microbiol 180:494-7. 2003
    ..While the two strains produced several AHLs in common, the differences in AHLs produced suggest that there may be significant differences in their patterns of quorum-sensing regulation...
  30. ncbi Intake of lignans is associated with serum enterolactone concentration in Finnish men and women
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    J Nutr 133:1830-3. 2003
    ..2 mg). The main dietary sources of lignans, i.e., whole grain, vegetables and fruits, are foods commonly associated with lower risk of cardiovascular diseases and cancer. Serum EL concentration is a feasible biomarker of lignan intake...
  31. pmc Reaction of acylated homoserine lactone bacterial signaling molecules with oxidized halogen antimicrobials
    S A Borchardt
    Global Research, ONDEO Nalco, Naperville, Illinois 60563, USA
    Appl Environ Microbiol 67:3174-9. 2001
    ..This work suggests that oxidized halogens may control biofilm not only via a cidal mechanism, but also by possibly interfering with 3-oxo acylated homoserine lactone-based cell signaling...
  32. ncbi The role of regulators in the expression of quorum-sensing signals in Pseudomonas aeruginosa
    Magnus G Fagerlind
    Department of Natural Sciences, Computational Molecular Biology, University of Skovde, Sweden
    J Mol Microbiol Biotechnol 6:88-100. 2003
    ..We also show experimental data that demonstrate that Vfr is required for signal production in the early phase of growth, but that in the latter stages of growth, the vfr mutant is able to synthesize wild-type levels of signal...
  33. ncbi Quorum quenching enzyme activity is widely conserved in the sera of mammalian species
    Fan Yang
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore 138673
    FEBS Lett 579:3713-7. 2005
    ..We further showed that the animal cell lines expressing three mouse PON genes, respectively, displayed strong AHL degradation activities...
  34. ncbi Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics
    Catalina Arevalo-Ferro
    Department of Microbiology, Technical University of Munich, Am Hochanger 4, D 85350 Freising, Germany
    Environ Microbiol 5:1350-69. 2003
    ..To strengthen this hypothesis we investigated the role of quorum sensing in the post-translational modification of HasAp, an extracellular protein required for the uptake of free and haemoglobin-bound haem...
  35. ncbi Interspecies communication between Burkholderia cepacia and Pseudomonas aeruginosa
    Shawn Lewenza
    Department of Microbiology and Infectious Diseases, University of Calgary Health Sciences Center, AB, Canada
    Can J Microbiol 48:707-16. 2002
    ..It is possible that a mixed bacterial population of B. cepacia and P. aeruginosa can coordinately regulate some of their virulence factors and influence the progression of lung disease due to infection with these organisms...
  36. pmc Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge
    Liang Cai
    Lineberger Comprehensive Cancer Center and Department of Cell and Developmental Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cell 128:915-29. 2007
    ..We conclude that Coronin 1B's coordination of filament formation by Arp2/3 complex and filament turnover by Cofilin is required for effective lamellipodial protrusion and cell migration...
  37. ncbi A quorum-sensing regulator controls expression of both the type IV secretion system and the flagellar apparatus of Brucella melitensis
    Rose May Delrue
    Research Unit in Molecular Biology URBM, University of Namur, 61 rue de Bruxelles, Namur, Belgium
    Cell Microbiol 7:1151-61. 2005
    ..In agreement with this hypothesis, we observed that, as virB operon, flagellar genes are controlled by the pheromone. All together these data support a model in which VjbR acts as a major regulator of virulence factors in Brucella...
  38. pmc SdiA of Salmonella enterica is a LuxR homolog that detects mixed microbial communities
    B Michael
    Department of Microbiology, The Ohio State University, Columbus, Ohio 43210 1292, USA
    J Bacteriol 183:5733-42. 2001
    ..SdiA appears to be the first AHL receptor discovered that detects signals emanating exclusively from other species...
  39. ncbi Is quorum sensing a side effect of diffusion sensing?
    Rosemary J Redfield
    Dept of Zoology, University of British Columbia, Vancouver, BC, Canada
    Trends Microbiol 10:365-70. 2002
    ..This diffusion sensing allows cells to regulate secretion of degradative enzymes and other effectors to minimize losses owing to extracellular diffusion and mixing...
  40. ncbi A microbial hormone, A-factor, as a master switch for morphological differentiation and secondary metabolism in Streptomyces griseus
    Sueharu Horinouchi
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Front Biosci 7:d2045-57. 2002
    ....
  41. ncbi P. aeruginosa quorum-sensing systems and virulence
    Roger S Smith
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Curr Opin Microbiol 6:56-60. 2003
    ..Therefore, via the regulation of multiple factors and the production of 3O-C(12)-HSL, quorum-sensing systems have a significant effect on the virulence of the bacteria and also on how the host responds to P. aeruginosa infections...
  42. pmc Generation of cell-to-cell signals in quorum sensing: acyl homoserine lactone synthase activity of a purified Vibrio fischeri LuxI protein
    A L Schaefer
    Department of Microbiology, University of Iowa, Iowa City 52242, USA
    Proc Natl Acad Sci U S A 93:9505-9. 1996
    ....
  43. ncbi Semisynthesis of new sarcophine derivatives with chemopreventive activity
    Isamu Katsuyama
    Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677 1848, USA
    J Nat Prod 65:1809-14. 2002
    ..In preliminary in vitro tests on inhibition of EBV-EA activation, compounds 10 and 12-15 have shown higher activity than the known chemopreventive agent sarcophytol A...
  44. pmc Vibrio harveyi quorum sensing: a coincidence detector for two autoinducers controls gene expression
    Kenny C Mok
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    EMBO J 22:870-81. 2003
    ..harveyi quorum-sensing circuit may function exclusively as a 'coincidence detector' that discriminates between conditions in which both autoinducers are present and all other conditions...
  45. ncbi ScbA from Streptomyces coelicolor A3(2) has homology to fatty acid synthases and is able to synthesize gamma-butyrolactones
    Nai Hua Hsiao
    Mikrobiologie Biotechnologie, Eberhard Karls Universitat Tubingen, Auf der Morgenstelle 28, 72076 Tubingen, Germany
    Microbiology 153:1394-404. 2007
    ....
  46. ncbi Protective effect of Z-ligustilide against amyloid beta-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains
    Xi Kuang
    State Key Laboratory of Biotherapy, West China Medical School, Sichuan University, Chengdu 610041, China
    Pharmacol Biochem Behav 92:635-41. 2009
    ..LIG would be a potential candidate for further preclinical study aimed at the prevention and treatment of cognitive deficits in AD...
  47. ncbi Ligustilide attenuates pain behavior induced by acetic acid or formalin
    Junrong Du
    Department of Applied Biology and Chemical Technology and National Key Laboratory of Chinese Medicine and Molecular Pharmacology Shenzhen, Hong Kong Polytechnic University, Kowloon, Hong Kong, PR China
    J Ethnopharmacol 112:211-4. 2007
    ....
  48. ncbi Anticancer and anti-inflammatory sulfur-containing semisynthetic derivatives of sarcophine
    Swapnali Sawant
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, 700 University Avenue, Monroe, LA 01209, USA
    Chem Pharm Bull (Tokyo) 54:1119-23. 2006
    ..The effect of these derivatives on highly malignant +SA mammary epithialial cell proliferation is reported. Anti-inflammatory potential of sarcophine and its derivatives is also demonstrated...
  49. ncbi Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice
    Xiaoying Zhang
    Department of Pharmaceutical Sciences, 1 Administration Lane, College of Pharmacy, Box 2202C, South Dakota State University, Brookings, SD 57007, USA
    Cancer Lett 253:53-9. 2007
    ..SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation...
  50. ncbi Parallel quorum sensing systems converge to regulate virulence in Vibrio cholerae
    Melissa B Miller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 110:303-14. 2002
    ..cholerae. This quorum sensing apparatus is unusually complex, as it is composed of at least three parallel signaling channels. We show that in V. cholerae these communication systems converge to control virulence...
  51. ncbi Regulatory circuits and communication in Gram-negative bacteria
    Andrée M Lazdunski
    Institut de Biologie Structurale et Microbiologie, 31 Chemin Joseph Aiguier, 13402 Marseille Cedex 20, France
    Nat Rev Microbiol 2:581-92. 2004
  52. pmc A mutation at proline-115 in the A-factor receptor protein of Streptomyces griseus abolishes DNA-binding ability but not ligand-binding ability
    H Onaka
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Bunkyo ku, Japan
    J Bacteriol 179:2748-52. 1997
    ..This is in agreement with the idea that A-factor binding to the COOH-terminal domain of ArpA causes a subtle conformational change of the distal NH2-terminal DNA-binding domain, resulting in dissociation of ArpA from DNA...
  53. pmc Biosynthesis of gamma-butyrolactone autoregulators that switch on secondary metabolism and morphological development in Streptomyces
    Jun ya Kato
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, University of Tokyo, Tokyo 113 8657, Japan
    Proc Natl Acad Sci U S A 104:2378-83. 2007
    ..AfsA is thus the key enzyme for the biosynthesis of gamma-butyrolactones...
  54. ncbi Serum enterolactone and risk of breast cancer: a case-control study in eastern Finland
    P Pietinen
    Department of Nutrition, National Public Health Institute, Mannerheimintie 166, 00300 Helsinki, Finland
    Cancer Epidemiol Biomarkers Prev 10:339-44. 2001
    ..Serum enterolactone level was significantly inversely associated with risk of breast cancer...
  55. ncbi Controlling infection by tuning in and turning down the volume of bacterial small-talk
    Miguel Camara
    School of Pharmaceutical Sciences, University of Nottingham, Nottingham, UK
    Lancet Infect Dis 2:667-76. 2002
    ..As a consequence, this event, now termed quorum sensing, represents a novel therapeutic target offering the opportunity to attenuate virulence, and thus control infection, by blocking cell-to-cell communication...
  56. ncbi An incident case-referent study on plasma enterolactone and breast cancer risk
    Kerstin Hultén
    Epidemiology Department of Public Health and Clinical Medicine, Umea University, Sweden
    Eur J Nutr 41:168-76. 2002
    ..Using a nested case-referent design, we evaluated the relationship between plasma levels of the lignan enterolactone and the risk of developing breast cancer...
  57. ncbi Cloning and characterization of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces clavuligerus
    Hyun Soo Kim
    Department of Microbiology, Keimyung University, 1000 Shindang dong, 704 701, Daegu, South Korea
    Arch Microbiol 182:44-50. 2004
    ..clavuligerus contains a gene for the gamma-butyrolactone autoregulator receptor...
  58. ncbi Crystal structure of a gamma-butyrolactone autoregulator receptor protein in Streptomyces coelicolor A3(2)
    Ryo Natsume
    Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, 113 8657, Tokyo, Japan
    J Mol Biol 336:409-19. 2004
    ....
  59. ncbi Dietary determinants of plasma enterolactone
    Neilann K Horner
    Cancer Prevention Research Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, WA 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 11:121-6. 2002
    ....
  60. ncbi Serum enterolactone concentration is not associated with breast cancer risk in a nested case-control study
    Annamari Kilkkinen
    Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland
    Int J Cancer 108:277-80. 2004
    ..67 (95% CI 0.95-2.95), 1.71 (95% CI 0.96-3.06) and 1.30 (95% CI 0.73-2.31), and p for trend was 0.48. Our findings do not support the hypothesis that high serum enterolactone concentration is associated with reduced risk of breast cancer...
  61. ncbi The effect of flaxseed supplementation in processed foods on serum fatty acids and enterolactone
    S Tarpila
    Department of Internal Medicine, The Mehiläinen Hospital, Helsinki, Finland
    Eur J Clin Nutr 56:157-65. 2002
    ..The purpose was to study the effects of flaxseed supplementation as a part of daily diet on serum lipids, fatty acids and plasma enterolactone...
  62. ncbi Urinary phytoestrogens and postmenopausal breast cancer risk
    I Den Tonkelaar
    Julius Center for Patient-Oriented Research, University Medical Center, Utrecht, The Netherlands
    Cancer Epidemiol Biomarkers Prev 10:223-8. 2001
    ..Such an effect may be smaller than expected and/or limited to specific subgroups of the population...
  63. pmc Bacterial growth stimulation with exogenous siderophore and synthetic N-acyl homoserine lactone autoinducers under iron-limited and low-nutrient conditions
    L L Guan
    Shimizu Laboratories, Marine Biotechnology Institute, Shimizu City, Shizuoka 424 0037, Japan
    Appl Environ Microbiol 66:2797-803. 2000
    ..The requirement of an exogenous siderophore and an HSL for heterologous siderophore production indicated the possibility that cell-cell communication between different species was occurring...
  64. ncbi Quorum sensing in bacteria
    M B Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Annu Rev Microbiol 55:165-99. 2001
    ..Presumably, this process bestows upon bacteria some of the qualities of higher organisms. The evolution of quorum sensing systems in bacteria could, therefore, have been one of the early steps in the development of multicellularity...
  65. ncbi Deletion of scbA enhances antibiotic production in Streptomyces lividans
    M J Butler
    Department of Molecular Microbiology, John Innes Centre, Colney Lane, Norwich NR4 7UH, UK
    Appl Microbiol Biotechnol 61:512-6. 2003
    ..Consequently, deletion of scbA may be useful in combination with other strategies to construct host strains capable of improved bioactive metabolite production...
  66. ncbi Luminescence control in the marine bacterium Vibrio fischeri: An analysis of the dynamics of lux regulation
    S James
    Centre for Marine Biofouling and Bio Innovation, The University of New South Wales, Sydney, 2052, Australia
    J Mol Biol 296:1127-37. 2000
    ..Finally, the model developed in this study provides a basis for analysing the impact of other levels of control upon lux regulation...
  67. pmc Multiple N-acyl homoserine lactone signals of Rhizobium leguminosarum are synthesized in a distinct temporal pattern
    R S Blosser-Middleton
    Department of Biology, University of South Florida, Tampa, FL 33620, USA
    J Bacteriol 183:6771-7. 2001
    ..This work provides an important global perspective for AHL regulation that both complements and contrasts with the results of previous studies performed with isolated gene systems...
  68. pmc Deducing receptor signaling parameters from in vivo analysis: LuxN/AI-1 quorum sensing in Vibrio harveyi
    Lee R Swem
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 134:461-73. 2008
    ..We find that quorum-sensing-mediated communication can be manipulated positively and negatively to control bacterial behavior and, more broadly, that signaling parameters can be deduced from in vivo data...
  69. ncbi A Pseudomonas aeruginosa quorum-sensing molecule influences Candida albicans morphology
    Deborah A Hogan
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115, USA
    Mol Microbiol 54:1212-23. 2004
    ..albicans-produced molecule also with a C12-backbone. The effects that bacteria have on the morphology of C. albicans represents one of the ways by which bacteria can influence the behaviour of fungal cells...
  70. ncbi Transcriptome analysis of quorum-sensing regulation and virulence factor expression in Pseudomonas aeruginosa
    Victoria E Wagner
    Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Box 672, Rochester, NY 14642, USA
    Vaccine 22:S15-20. 2004
    ..Transcriptome results indicate that the QS system is far more complex than previously proposed. Interestingly, we found that many QS-regulated genes encoding virulence products were expressed in all conditions investigated...
  71. pmc Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones
    Gunnar F Kaufmann
    Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 102:309-14. 2005
    ..These findings merit new attention such that other previously identified autoinducers be reevaluated for additional biological functions...
  72. pmc Rapid acyl-homoserine lactone quorum signal biodegradation in diverse soils
    Ya Juan Wang
    Environmental Science and Engineering, WM Keck Laboratories, California Institute of Technology, Pasadena, CA 91125, USA
    Appl Environ Microbiol 71:1291-9. 2005
    ..Depending on the context, biological signal decay might either promote or complicate cellular communications and the accuracy of population density-based controls on gene expression in species-rich ecosystems...
  73. ncbi Revisiting the quorum-sensing hierarchy in Pseudomonas aeruginosa: the transcriptional regulator RhlR regulates LasR-specific factors
    Valérie Dekimpe
    INRS Institut Armand Frappier, Laval, Quebec H7V 1B7, Canada
    Microbiology 155:712-23. 2009
    ..This work demonstrates that the QS hierarchy is more complex than the model simply presenting the las system above the rhl system...
  74. ncbi The biocontrol strain Pseudomonas fluorescens F113 produces the Rhizobium small bacteriocin, N-(3-hydroxy-7-cis-tetradecenoyl)homoserine lactone, via HdtS, a putative novel N-acylhomoserine lactone synthase
    B E Laue
    School of Pharmaceutical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Microbiology 146:2469-80. 2000
    ..HdtS may therefore constitute a member of a third protein family capable of AHL biosynthesis...
  75. pmc Acyl-homoserine lactone production is more common among plant-associated Pseudomonas spp. than among soilborne Pseudomonas spp
    M Elasri
    Institut des Sciences Vegetales, CNRS UPR040, 91198 Gif sur Yvette Cedex, France
    Appl Environ Microbiol 67:1198-209. 2001
    ..This gene organization, with luxI and luxR homologues facing each other and overlapping, has been found so far only in the enteric bacteria Erwinia and Pantoea and in the related species P. syringae pv. tabaci...
  76. ncbi Direct binding of the quorum sensing regulator CepR of Burkholderia cenocepacia to two target promoters in vitro
    Christine L Weingart
    Department of Biology, Denison University, Granville, OH 43023, USA
    Mol Microbiol 57:452-67. 2005
    ..These binding sites included a 16-nucleotide imperfect dyad symmetry. Both CepR binding sites are centred approximately 44 nucleotides upstream of the respective transcription start sites...
  77. ncbi Regulation of gene expression by cell-to-cell communication: acyl-homoserine lactone quorum sensing
    C Fuqua
    Department of Biology, Indiana University, Bloomington, Indiana 47405, USA
    Annu Rev Genet 35:439-68. 2001
    ..Recent studies have begun to integrate acyl-HSL quorum sensing into global regulatory networks and establish its role in developing and maintaining the structure of bacterial communities...
  78. pmc Effect of sdiA on biosensors of N-acylhomoserine lactones
    Amber Lindsay
    Department of Microbiology, Ohio State University, Columbus, 43210 1292, USA
    J Bacteriol 187:5054-8. 2005
    ..coli biosensor strains that lack sdiA. The set includes control reporters that allow the luxR dependence of responses to be determined...
  79. pmc Identification, timing, and signal specificity of Pseudomonas aeruginosa quorum-controlled genes: a transcriptome analysis
    Martin Schuster
    Department of Microbiology and W M Keck Microbial Communities and Cell Signaling Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Bacteriol 185:2066-79. 2003
    ..Acyl-homoserine lactone quorum sensing appears to be a system that allows ordered expression of hundreds of genes during P. aeruginosa growth in culture...
  80. pmc An extracellular factor regulates expression of sdiA, a transcriptional activator of cell division genes in Escherichia coli
    J Garcia-Lara
    Department of Microbiology, University of Connecticut Health Center, Farmington 06030 3205, USA
    J Bacteriol 178:2742-8. 1996
    ..This suggests that the response is specific for PsdiA and for promoters that are regulated by the sdiA gene product and that cell-to-cell signalling may play a role in regulating expression of this group of genes...
  81. pmc Quorum sensing in Aeromonas hydrophila and Aeromonas salmonicida: identification of the LuxRI homologs AhyRI and AsaRI and their cognate N-acylhomoserine lactone signal molecules
    S Swift
    Department of Applied Biochemistry and Food Science, University of Nottingham, Leicestershire, United Kingdom
    J Bacteriol 179:5271-81. 1997
    ..2 in the test) of protease in the culture supernatant. These data add A. hydrophila and A. salmonicida to the growing family of gram-negative bacteria now known to control gene expression through quorum sensing...
  82. ncbi Cell-cell communication by quorum sensing and dimension-reduction
    Johannes Muller
    Centre for Mathematical Sciences, Technical University Munich, Boltzmannstr 3, 85748 Garching Munich, Germany
    J Math Biol 53:672-702. 2006
    ..Concluding, we apply the modeling approach to spatially structured experimental data...
  83. pmc Interspecies communication in bacteria
    Michael J Federle
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    J Clin Invest 112:1291-9. 2003
    ..AI-2 is a particularly attractive candidate for such studies because of its widespread use in the microbial kingdom...
  84. pmc Quorum-sensing system and stationary-phase sigma factor (rpoS) of the onion pathogen Burkholderia cepacia genomovar I type strain, ATCC 25416
    Claudio Aguilar
    Bacteriology Group, International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34012 Trieste, Italy
    Appl Environ Microbiol 69:1739-47. 2003
    ..cepacia has a negative effect on rpoS expression as determined by using an rpoS-lacZ transcriptional fusion; on the other hand, rpoS-null mutants displayed no difference in the accumulation of HSL signal molecules...
  85. pmc Identification of a quorum-sensing signal molecule in the facultative intracellular pathogen Brucella melitensis
    Bernard Taminiau
    Unité de Recherche en Biologie Moléculaire URBM, Laboratoire d Immunologie et Microbiologie, Facultes Universitaires Notre Dame de la Paix, 5000 Namur, Belgium
    Infect Immun 70:3004-11. 2002
    ..This mimics events seen during the stationary phase of growth and suggests that quorum sensing may play a role in the control of virulence in Brucella...
  86. ncbi Regulation of tylosin production: role of a TylP-interactive ligand
    Dawn R D Bignell
    Department of Biochemistry, University of Leicester, Leicester LE1 9HN, UK
    Mol Microbiol 63:838-47. 2007
    ..Continued synthesis of tylosin by the disrupted strains contrasts with other reports that loss of gamma-butyrolactones abolishes antibiotic production...
  87. pmc Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production
    M G Surette
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, North West, Calgary, Alberta, T2N 4N1, Canada
    Proc Natl Acad Sci U S A 96:1639-44. 1999
    ..coli DH5alpha luxSE.c. gene shows that it contains a frameshift mutation resulting in premature truncation of the LuxSE.c. protein. Our results indicate that the luxS genes define a new family of autoinducer-production genes...
  88. ncbi Long- and short-chain plant-produced bacterial N-acyl-homoserine lactones become components of phyllosphere, rhizosphere, and soil
    Russell A Scott
    Department of Biological Sciences, Rochester Institute of Technology, Rochester, NY 14623, USA
    Mol Plant Microbe Interact 19:227-39. 2006
    ..Therefore, it is feasible to use bioengineered plants to supplement soils with specific acyl-HSLs to modulate bacterial phenotypes and plant-associated bacterial community structures...
  89. pmc Quorum sensing on a global scale: massive numbers of bioluminescent bacteria make milky seas
    Kenneth H Nealson
    Department of Molecular and Cellular Biology, 16 Divinity Avenue, Harvard University, Cambridge, MA 02138 2020, USA
    Appl Environ Microbiol 72:2295-7. 2006
  90. ncbi Characterization of N-acyl homoserine lactone overproducing mutants of Burkholderia multivorans ATCC 17616
    Fude Yao
    Department of Microbiology, University of Massachusetts, Amherst, MA 01003 USA
    FEMS Microbiol Lett 206:201-7. 2002
    ..We conclude that the mutations leading to AHL overproduction lie outside the bmuI/bmuR locus...
  91. ncbi Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound
    Morten Hentzer
    Department of Molecular Microbiology, BioCentrum DTU, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Microbiology 148:87-102. 2002
    ..It does, however, affect the architecture of the biofilm and enhances the process of bacterial detachment, leading to a loss of bacterial biomass from the substratum...
  92. ncbi [Quorum sensing of genes expression--perspective drug target against bacterial pathogenicity]
    I A Khmel'
    Mol Biol (Mosk) 40:195-210. 2006
    ..Such a strategy allows to avoid a wide dissemination of resistant forms of pathogenic bacteria and the formation of biofilms increasing in many times the resistance of bacteria to drug preparations...
  93. pmc Bacterial small-molecule signaling pathways
    Andrew Camilli
    Howard Hughes Medical Institute, 136 Harrison Avenue, Boston, MA 02111 1817, USA
    Science 311:1113-6. 2006
    ..We suggest how these two pathways may converge to control complex processes including multicellularity, biofilm formation, and virulence. We also outline new questions that have arisen from recent studies in these fields...
  94. pmc GABA controls the level of quorum-sensing signal in Agrobacterium tumefaciens
    Romain Chevrot
    Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, Avenue de la Terrasse, Gif sur Yvette 91 198, France
    Proc Natl Acad Sci U S A 103:7460-4. 2006
    ..The GABA signal represents a potential target for the development of a strategy to control the virulence of bacterial pathogens...
  95. ncbi PtxR modulates the expression of QS-controlled virulence factors in the Pseudomonas aeruginosa strain PAO1
    Nancy L Carty
    Department of Microbiology and Immunology, Texas Tech University Health Sciences Center, Lubbock, TX 79430 5907, USA
    Mol Microbiol 61:782-94. 2006
    ..These results suggest that PtxR negatively regulates the expression of the rhamnolipid and pyocyanin genes through rhlI and the pqsABCDE operon while it positively regulates the expression of lasB through lasI...
  96. pmc Indole is an inter-species biofilm signal mediated by SdiA
    Jintae Lee
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, College Station, TX 77843 3122, USA
    BMC Microbiol 7:42. 2007
    ..g., astD, tnaB, gabT), multi-drug exporters, and the pathogenicity island of E. coli; however, its impact on biofilm formation has not been well-studied...
  97. ncbi A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa
    Abdelhamid Abbas
    Microbiology Department, National University of Ireland, Cork, Ireland
    FEMS Microbiol Lett 274:269-78. 2007
    ..These functions were independent of the role of TonB1 in iron uptake. This is the first time that a link has been established between TonB1 activity and QS...
  98. pmc Inhibition of quorum sensing-controlled virulence factor production in Pseudomonas aeruginosa by South Florida plant extracts
    Allison Adonizio
    Department of Biological Sciences, Florida International University, HLS673A, University Park, Miami, FL 33199, USA
    Antimicrob Agents Chemother 52:198-203. 2008
    ..Extracts of all plants caused the inhibition of QS genes and QS-controlled factors, with marginal effects on bacterial growth, suggesting that the quorum-quenching mechanisms are unrelated to static or cidal effects...
  99. ncbi Pseudomonas aeruginosa quorum-sensing signal molecules induce IL-8 production by human corneal epithelial cells
    Hua Zhu
    Institute for Eye Research, Vision CRC and School of Optometry and Vision Science, The University of New South Wales, Sydney, NSW 2052, Australia
    Eye Contact Lens 34:179-81. 2008
    ..The aim of the present study was to evaluate whether the quorum-sensing molecules of Pseudomonas aeruginosa could induce the production of interleukin-8 (IL-8) in human corneal epithelial (HCE) cells in vitro...
  100. ncbi Use of quantitative real-time RT-PCR to analyse the expression of some quorum-sensing regulated genes in Pseudomonas aeruginosa
    Thomas Schwartz
    Department of Environmental Microbiology, Institute for Technical Chemistry Water Technology and Geotechnology Division, Forschungszentrum Karlsruhe, P O Box 3640, 76021, Karlsruhe, Germany
    Anal Bioanal Chem 387:513-21. 2007
    ..It was shown that the genes under investigation were up-regulated in mature biofilm in the presence of the signal molecule N-(3-oxododecanoyl)-L-homoserine lactone...
  101. pmc A structurally unrelated mimic of a Pseudomonas aeruginosa acyl-homoserine lactone quorum-sensing signal
    Ute Müh
    Vertex Pharmaceuticals Incorporated, 130 Waverly Street, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:16948-52. 2006
    ..The triphenyl mimic is an excellent scaffold for developing quorum-sensing inhibitors, and its stability and potency make it ideal for biotechnology uses such as heterologous gene expression...

Research Grants38

  1. Neuropharmacology of GHB discrimination
    Wouter Koek; Fiscal Year: 2010
    ..Increased knowledge about the activation and modulation of GABAB systems will help to develop effective approaches to treating sleep-, drug abuse-, and other CNS disorders. ..
  2. Discriminative Stimulus Effects of Alcohol in Mice
    Wouter Koek; Fiscal Year: 2007
    ..This future research will increase our understanding of risk factors for alcoholism and drug abuse and will help the development of effective approaches to prevention and treatment. [unreadable] [unreadable] [unreadable]..
  3. OLFACTORY NEURONS: A MODEL FOR NEUROTROPHIN FUNCTION
    Gabriele Ronnett; Fiscal Year: 2004
    ..Understanding these mechanisms is essential to our ability to manipulate that process. ..
  4. Fatty Acid Synthase Inhibition and Neuronal Metabolism
    Gabriele Ronnett; Fiscal Year: 2005
    ..In Aim III we will test the hypothesis that those pathways are relevant in vivo by modulating these signaling pathways in the presence of C75 and determining which pathways affect feeding and weight loss. ..
  5. GHB: Discrimination and effects on learning
    Lisa Baker; Fiscal Year: 2003
    ..Behavior under these assays is sensitive to other abused drugs. Therefore, these assays may be of value in characterizing the effects of GHB. ..
  6. CNS Fatty Acid Metabolism in Regulation of Food Intake
    Susan Aja; Fiscal Year: 2007
    ..We will measure changes in intracellular AMP/ATP ratio and activity of AMP-activated protein kinase, levels of mRNAs for feeding-related neuropeptides, and neuropeptide production and release. ..
  7. Endogenous Estrogens and Colorectal Cancer Risk in Women
    Anne Zeleniuch Jacquotte; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Estrogen Metabolism Related Genes & Endometrial Cancer
    Anne Zeleniuch Jacquotte; Fiscal Year: 2007
    ..We will also further evaluate the functional importance of several gene polymorphisms by examining their associations with circulating levels of estrogens and estrogen metabolites. [unreadable] [unreadable]..
  9. Olfactory Neurons--Model for PACAP Neurotrophic Function
    Gabriele Ronnett; Fiscal Year: 2005
    ..These studies will elucidate the function and mechanisms underlying bioactive peptide neurotrophism in the CNS. ..
  10. STUDIES OF FAS INHIBITION IN HUMAN BREAST CANCER CELLS
    FRANCIS KUHAJDA; Fiscal Year: 2003
    ..These studies will advance our understanding of the action of FAS inhibition, further the development of this pathway for drug development, and likely lead to additional novel therapeutic targets. ..
  11. AMP Activated Kinase in Neurons
    Gabriele Ronnett; Fiscal Year: 2008
    ..Aim 2 will study the role and regulation of AMPK in an ischemia-reperfusion model. Aim 3 will determine the mechanisms by which modulation of the FAS and CPT-1 activities alters AMPK activity and affords neuroprotection. ..
  12. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  13. INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS
    Stephen C Winans; Fiscal Year: 2010
    ..Direct targets of YenR and YenS will be identified and assessed for their roles in the biology and ecology of Y. enterocolitica and Y. pestis. ..
  14. FMRI of Absence Seizure Activity in Awake Animals
    Jeffrey Tenney; Fiscal Year: 2006
    ..abstract_text> ..
  15. Energy dysregulation: The role of AMPK in stroke
    LOUISE DEBORAH MCCULLOUGH; Fiscal Year: 2010
    ..A multi-faceted approach is clearly needed to develop efficacious neuroprotective agents that will benefit stroke patients. Manipulation of AMPK levels represents a novel approach to neuroprotection. ..
  16. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  17. Mouse model of binge drinking-induced neurotoxicity
    CHRISTOPHER DE FIEBRE; Fiscal Year: 2006
    ..Via the latter, the development of alpha7-selective agents as therapeutics to treat binge drinking-induced neurotoxicity may be fostered. ..
  18. Cell Wall Components' Role in Enterococcal Endocarditis
    Gary Dunny; Fiscal Year: 2006
    ..faecalis virulence. 2) Determine the functional domains of Asc10 that confer the activities identified in Aim 1. 3) Examine the expression of bacterial and host genes during the course of infections. ..
  19. Theory of the Chemistry of NO, HNO, OONO-, and RSNO
    KENDALL HOUK; Fiscal Year: 2009
    ..The success of the research described here can lead to new tools for study of physiological processes and drugs for hypertension, cardiac failure, and other biological processes involving NO metabolism. ..
  20. Advanced Reproductive Age and Environmental Health
    Stephanie Engel; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. Role of OxyR in P. aeruginosa Biofilm Resistance to H202
    DANIEL HASSETT; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Transcriptional Profiles of Escherichia coli Biofilms
    Robert McLean; Fiscal Year: 2002
    ..Overall, this project will explain several fundamental aspects of E. coli biofilm growth and suggest possible targets for future antibiotic research. ..
  23. IRON, FUR AND ALGINATE PRODUCTION IN P AERUGINOSA
    DANIEL HASSETT; Fiscal Year: 2002
    ..Information derived from the studies proposed herein will advance the current knowledge about the role of these factors in the pathogenesis of P. aeruginosa infections in CF. ..
  24. ORIGINS OF STEREOSELECTIVE CATALYSIS BY ANTIBODIES
    KENDALL HOUK; Fiscal Year: 2002
    ..abstract_text> ..
  25. A BACTERIAL GROUP II INTRON INVOLVED IN CONJUGATION
    Gary Dunny; Fiscal Year: 2002
    ..Identification and analysis of small molecule splicing inhibitors using a splicing-dependent conjugation assay. ..
  26. Proteogenome of Anaerobic P. aeruginosa in CF Mucus
    DANIEL HASSETT; Fiscal Year: 2003
    ..Our LONG TERM GOAL is to identify cellular targets that inhibit or significantly compromise the denitrification process that is occurring by P. aeruginosa in the CF airways. ..
  27. EVOLUTION OF DNA UPTAKE IN HAEMOPHILUS AND NEISSERIA
    ROSEMARY REDFIELD; Fiscal Year: 2003
    ..If a protein can be identified, it will be sequenced. Attempts will also be made to determine whether the USS are protected in nucleoids. ..
  28. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  29. ORGANOMETALLIC SYNTHESES OF BIOACTIVE COMPOUNDS
    LOUIS HEGEDUS; Fiscal Year: 2003
    ..abstract_text> ..
  30. B.pseudomallei bioterrorism and quorum sensing
    DANIEL HASSETT; Fiscal Year: 2003
    ..These studies will provide important information that will lead to countermeasures against a potential bioterrorist attack using the potentially lethal gram-negative bacterium, B. pseudomallei. ..
  31. ASM Conference on Biofilms 2003
    Matthew Parsek; Fiscal Year: 2003
    ..This meeting will allow researchers to gather and discuss their work. We request funds for this meeting and hope that NIH will support ASM in providing financial assistance. ..
  32. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  33. Variations in plasma phytoestrogen levels in Europe
    Petra Peeters; Fiscal Year: 2004
    ..This pilot study will determine whether the variation of phytoestrogen concentrations in the European EPIC population is sufficient to justify further large-scale prospective nested case-control studies. ..
  34. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  35. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  36. Self-administration of GHB, GBL and 1,4-BD in baboons
    AMY GOODWIN; Fiscal Year: 2005
    ..The results of the proposed study will characterize the abuse liability of GHB, GBL, and 1,4-BD by use of a well-established method of abuse liability testing in non-human primates. ..