lactones

Summary

Summary: Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.

Top Publications

  1. ncbi Strigolactones affect lateral root formation and root-hair elongation in Arabidopsis
    Yoram Kapulnik
    Institute of Plant Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
    Planta 233:209-16. 2011
  2. ncbi Inhibition of shoot branching by new terpenoid plant hormones
    Mikihisa Umehara
    RIKEN Plant Science Center, Tsurumi, Yokohama 230 0045, Japan
    Nature 455:195-200. 2008
  3. ncbi Strigolactone inhibition of shoot branching
    Victoria Gomez-Roldan
    Universite de Toulouse, UPS, CNRS, Surface Cellulaire et Signalisation chez les Végétaux, 24 Chemin de Borde Rouge, F 31326 Castanet Tolosan, France
    Nature 455:189-94. 2008
  4. pmc N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
    Edwin A Yates
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Infect Immun 70:5635-46. 2002
  5. ncbi Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
    Kohki Akiyama
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Nature 435:824-7. 2005
  6. ncbi d14, a strigolactone-insensitive mutant of rice, shows an accelerated outgrowth of tillers
    Tomotsugu Arite
    Ishikawa Prefectural University, Nonoichi, Ishikawa 921 8836, Japan
    Plant Cell Physiol 50:1416-24. 2009
  7. ncbi Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
  8. ncbi Strigolactones are regulators of root development
    Hinanit Koltai
    Institute of Plant Sciences, Agricultural Research Organization ARO, The Volcani Center, Bet Dagan, Israel
    New Phytol 190:545-9. 2011
  9. pmc Contribution of strigolactones to the inhibition of tiller bud outgrowth under phosphate deficiency in rice
    Mikihisa Umehara
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045 Japan
    Plant Cell Physiol 51:1118-26. 2010
  10. pmc DWARF27, an iron-containing protein required for the biosynthesis of strigolactones, regulates rice tiller bud outgrowth
    Hao Lin
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 21:1512-25. 2009

Detail Information

Publications387 found, 100 shown here

  1. ncbi Strigolactones affect lateral root formation and root-hair elongation in Arabidopsis
    Yoram Kapulnik
    Institute of Plant Sciences, Agricultural Research Organization, The Volcani Center, Bet Dagan, Israel
    Planta 233:209-16. 2011
    ..SLs effect on lateral root formation and root-hair elongation may suggest a role for SLs in the regulation of root development; perhaps, as a response to growth conditions...
  2. ncbi Inhibition of shoot branching by new terpenoid plant hormones
    Mikihisa Umehara
    RIKEN Plant Science Center, Tsurumi, Yokohama 230 0045, Japan
    Nature 455:195-200. 2008
    ..Here we show that levels of strigolactones, a group of terpenoid lactones, are significantly reduced in some of the branching mutants...
  3. ncbi Strigolactone inhibition of shoot branching
    Victoria Gomez-Roldan
    Universite de Toulouse, UPS, CNRS, Surface Cellulaire et Signalisation chez les Végétaux, 24 Chemin de Borde Rouge, F 31326 Castanet Tolosan, France
    Nature 455:189-94. 2008
    ..Furthermore, ccd8 mutants demonstrate the diverse effects of strigolactones in shoot branching, mycorrhizal symbiosis and parasitic weed interaction...
  4. pmc N-acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa
    Edwin A Yates
    School of Biosciences, University of Birmingham, Birmingham B15 2TT, United Kingdom
    Infect Immun 70:5635-46. 2002
    ....
  5. ncbi Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
    Kohki Akiyama
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Nature 435:824-7. 2005
    ..Strigolactones are a group of sesquiterpene lactones, previously isolated as seed-germination stimulants for the parasitic weeds Striga and Orobanche...
  6. ncbi d14, a strigolactone-insensitive mutant of rice, shows an accelerated outgrowth of tillers
    Tomotsugu Arite
    Ishikawa Prefectural University, Nonoichi, Ishikawa 921 8836, Japan
    Plant Cell Physiol 50:1416-24. 2009
    ..highly branched mutants of pea, Arabidopsis and rice have demonstrated that strigolactones, a group of terpenoid lactones, act as a new hormone class, or its biosynthetic precursors, in inhibiting shoot branching...
  7. ncbi Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
    Sesquiterpene lactones (SLs) have potent anti-inflammatory properties. We have shown previously that they exert this effect in part by inhibiting activation of the transcription factor NF-kappaB, a central regulator of the immune response...
  8. ncbi Strigolactones are regulators of root development
    Hinanit Koltai
    Institute of Plant Sciences, Agricultural Research Organization ARO, The Volcani Center, Bet Dagan, Israel
    New Phytol 190:545-9. 2011
    ..Strigolactone regulation of plant development suggests that they are coordinators of shoot and root development and mediators of plant responses to environmental conditions...
  9. pmc Contribution of strigolactones to the inhibition of tiller bud outgrowth under phosphate deficiency in rice
    Mikihisa Umehara
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045 Japan
    Plant Cell Physiol 51:1118-26. 2010
    ....
  10. pmc DWARF27, an iron-containing protein required for the biosynthesis of strigolactones, regulates rice tiller bud outgrowth
    Hao Lin
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Cell 21:1512-25. 2009
    ..Strigolactones, a group of terpenoid lactones, have been recently identified as products of the MAX/RMS/D pathway that inhibits axillary bud outgrowth...
  11. ncbi The LuxS family of bacterial autoinducers: biosynthesis of a novel quorum-sensing signal molecule
    S Schauder
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Mol Microbiol 41:463-76. 2001
    ..This result suggests that, unlike quorum sensing via the family of related homoserine lactone autoinducers, AI-2 is a unique, 'universal' signal that could be used by a variety of bacteria for communication among and between species...
  12. pmc Strigolactones are transported through the xylem and play a key role in shoot architectural response to phosphate deficiency in nonarbuscular mycorrhizal host Arabidopsis
    Wouter Kohlen
    Laboratory of Plant Physiology, Wageningen University, 6708 PB Wageningen, The Netherlands
    Plant Physiol 155:974-87. 2011
    ..Together, these results show that xylem-transported strigolactones contribute to the regulation of shoot architectural response to phosphate-limiting conditions...
  13. pmc Physiological effects of the synthetic strigolactone analog GR24 on root system architecture in Arabidopsis: another belowground role for strigolactones?
    Carolien Ruyter-Spira
    Laboratory of Plant Physiology, Wageningen University, 6700 AR Wageningen, The Netherlands
    Plant Physiol 155:721-34. 2011
    ..We postulate that the tightly balanced auxin-strigolactone interaction is the basis for the mechanism of the regulation of the plants' root-to-shoot ratio...
  14. ncbi Small talk. Cell-to-cell communication in bacteria
    Bonnie L Bassler
    Department of Molecular Biology, Princeton University, NJ 08544, USA
    Cell 109:421-4. 2002
    ..A diverse array of secreted chemical signal molecules and signal detection apparatuses facilitate highly productive intra- and interspecies relationships...
  15. ncbi The contribution of MvfR to Pseudomonas aeruginosa pathogenesis and quorum sensing circuitry regulation: multiple quorum sensing-regulated genes are modulated without affecting lasRI, rhlRI or the production of N-acyl-L-homoserine lactones
    Eric Déziel
    Department of Surgery, Harvard Medical School, Massachusetts General Hospital, 50 Blossom Street, MA, USA
    Mol Microbiol 55:998-1014. 2005
    ..This study provides novel insights into the unique role of the MvfR system in AHL-mediated QS and further supports its importance in P. aeruginosa pathogenesis...
  16. ncbi Nitrogen deficiency as well as phosphorus deficiency in sorghum promotes the production and exudation of 5-deoxystrigol, the host recognition signal for arbuscular mycorrhizal fungi and root parasites
    Kaori Yoneyama
    Weed Science Center, Utsunomiya University, 350 Mine machi, Utsunomiya, Japan
    Planta 227:125-32. 2007
    ..These results suggest that strigolactones may be rapidly released after their production in the roots. Unlike the situation in the roots, neither N nor P deficiency affected the low content of 5-deoxystrigol in sorghum shoot tissues...
  17. pmc Look who's talking: communication and quorum sensing in the bacterial world
    Paul Williams
    Institute of Infection, Immunity and Inflammation, Centre for Biomolecular Sciences, School of Molecular Medical Sciences, University of Nottingham, Nottingham NG7 2RD, UK
    Philos Trans R Soc Lond B Biol Sci 362:1119-34. 2007
    ..Quorum sensing also crosses the prokaryotic-eukaryotic boundary since quorum sensing-dependent signalling can be exploited or inactivated by both plants and mammals...
  18. ncbi Strigolactones: discovery of the elusive shoot branching hormone
    Elizabeth A Dun
    The University of Queensland, Australian Research Council Centre of Excellence for Integrative Legume Research, St Lucia, QLD 4072, Australia
    Trends Plant Sci 14:364-72. 2009
    ....
  19. ncbi Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity
    Steven J Kridel
    Cancer Research Center, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cancer Res 64:2070-5. 2004
    ..By virtue of its ability to inhibit fatty acid synthase, Orlistat halts tumor cell proliferation, induces tumor cell apoptosis, and inhibits the growth of PC-3 tumors in nude mice...
  20. pmc Structure of the autoinducer required for expression of Pseudomonas aeruginosa virulence genes
    J P Pearson
    Department of Microbiology, University of Iowa, Iowa City 52242
    Proc Natl Acad Sci U S A 91:197-201. 1994
    ..The elucidation of the PAI structure suggests therapeutic approaches toward control of P. aeruginosa infections...
  21. pmc Communication among oral bacteria
    Paul E Kolenbrander
    Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892 4350, USA
    Microbiol Mol Biol Rev 66:486-505, table of contents. 2002
    ..A successful search for genes critical for mixed-species community organization will be accomplished only when it is conducted with mixed-species communities...
  22. ncbi The strigolactone story
    Xiaonan Xie
    Weed Science Center, Utsunomiya University, Utsunomiya 321 8505, Japan
    Annu Rev Phytopathol 48:93-117. 2010
    ..Furthermore, SLs are suggested to have other biological functions in rhizosphere communications and in plant growth and development...
  23. pmc The pea TCP transcription factor PsBRC1 acts downstream of Strigolactones to control shoot branching
    Nils Braun
    Institut Jean Pierre Bourgin, INRA UMR1318 INRA AgroParisTech, F 78000 Versailles, France
    Plant Physiol 158:225-38. 2012
    ..This phenotype indicates a localized regulation of branching at these nodes specific to pea...
  24. pmc FINE CULM1 (FC1) works downstream of strigolactones to inhibit the outgrowth of axillary buds in rice
    Kosuke Minakuchi
    Graduate School of Agriculture and Life Sciences, University of Tokyo, Yayoi, Bunkyo, Tokyo, 113 8657 Japan
    Plant Cell Physiol 51:1127-35. 2010
    ..On the other hand, the expression level of FC1 is negatively regulated by cytokinin treatment. We propose that FC1 acts as an integrator of multiple signaling pathways and is essential to the fine-tuning of shoot branching in rice...
  25. pmc Mycobacterium tuberculosis Rv3802c encodes a phospholipase/thioesterase and is inhibited by the antimycobacterial agent tetrahydrolipstatin
    Sarah K Parker
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, United States of America
    PLoS ONE 4:e4281. 2009
    ..tuberculosis pathogenesis, identification of a novel cell wall enzyme and its inhibition has therapeutic and diagnostic implications...
  26. ncbi Targeting lipid metabolism by the lipoprotein lipase inhibitor orlistat results in apoptosis of B-cell chronic lymphocytic leukemia cells
    C P Pallasch
    Laboratory of Cellular Immunotherapy, Clinic I of Internal Medicine, University of Cologne, Cologne, Germany
    Leukemia 22:585-92. 2008
    ..003). In summary, alterations of lipid metabolism are involved in CLL pathogenesis and might represent a novel therapeutic target in CLL...
  27. pmc Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing
    Matthew B Neiditch
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cell 126:1095-108. 2006
    ..We propose that formation of this asymmetric quaternary structure is responsible for repressing the kinase activity of both LuxQ subunits and triggering the transition of V. harveyi into quorum-sensing mode...
  28. ncbi Tomato strigolactones are derived from carotenoids and their biosynthesis is promoted by phosphate starvation
    Juan Antonio Lopez-Raez
    Plant Research International, P O Box 16, NL 6700 AA Wageningen, The Netherlands
    New Phytol 178:863-74. 2008
    ..The dual activity of these signalling compounds in attracting beneficial AM fungi and detrimental parasitic plants is further strengthened by environmental conditions such as phosphate availability...
  29. ncbi Phosphorus deficiency in red clover promotes exudation of orobanchol, the signal for mycorrhizal symbionts and germination stimulant for root parasites
    Kaori Yoneyama
    United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchu 183 8509, Japan
    Planta 225:1031-8. 2007
    ..This is the first report demonstrating that nutrient availability influences both symbiotic and parasitic interactions in the rhizosphere...
  30. pmc Bacteria-host communication: the language of hormones
    Vanessa Sperandio
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9048, USA
    Proc Natl Acad Sci U S A 100:8951-6. 2003
    ..Given that eukaryotic cell-to-cell signaling typically occurs through hormones, and that bacterial cell-to-cell signaling occurs through QS, we speculate that QS might be a "language" by which bacteria and host cells communicate...
  31. pmc Structural requirements of strigolactones for hyphal branching in AM fungi
    Kohki Akiyama
    Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1 1 Gakuen cho, Nakaku, Sakai, Osaka, 599 8531 Japan
    Plant Cell Physiol 51:1104-17. 2010
    Strigolactones are a group of terpenoid lactones that act as a host-derived signal in the rhizosphere communication of plants with arbuscular mycorrhizal (AM) fungi and root parasitic weeds as well as an endogenous plant hormone ..
  32. pmc Strigolactones stimulate arbuscular mycorrhizal fungi by activating mitochondria
    Arnaud Besserer
    UMR 5546, Pôle de Biotechnologies Végétales, Castanet Tolosan, France
    PLoS Biol 4:e226. 2006
    ..This effect was not found with other sesquiterperne lactones known as germination stimulants of parasitic weeds...
  33. ncbi Strigolactones enhance competition between shoot branches by dampening auxin transport
    Scott Crawford
    Department of Biology, University of York, York, UK
    Development 137:2905-13. 2010
    ....
  34. pmc Methylthioadenosine/S-adenosylhomocysteine nucleosidase, a critical enzyme for bacterial metabolism
    Nikhat Parveen
    Department of Microbiology and Molecular Genetics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 225 Warren Street, Newark, NJ 07103 3535, USA
    Mol Microbiol 79:7-20. 2011
    ..Therefore, new inhibitors are currently being explored for development of potential novel broad-spectrum antimicrobials...
  35. ncbi Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2
    Patricia McGettigan
    Discipline of Clinical Pharmacology, School of Medicine and Public Health, The University of Newcastle, New South Wales, Australia
    JAMA 296:1633-44. 2006
    ..Regulatory agencies have provided variable advice regarding the cardiovascular risks with older nonselective NSAIDs...
  36. ncbi Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium
    Anne Brockhoff
    Department of Molecular Genetics, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, 14558 Nuthetal, Germany
    J Agric Food Chem 55:6236-43. 2007
    Sesquiterpene lactones are a major class of natural bitter compounds occurring in vegetables and culinary herbs as well as in aromatic and medicinal plants, where they often represent the main gustatory and pharmacologically active ..
  37. pmc RND type efflux pump system MexAB-OprM of Pseudomonas aeruginosa selects bacterial languages, 3-oxo-acyl-homoserine lactones, for cell-to-cell communication
    Shu Minagawa
    Department of Microbiology and Infection Control Science, Kyoto Pharmaceutical University, Yamashina, Kyoto 607 8414, Japan
    BMC Microbiol 12:70. 2012
    ..Gram-negative bacteria use a variety of self-produced autoinducers such as acylated homoserine lactones (acyl-HSLs) as signal compounds for quorum sensing (QS) within and between bacterial species...
  38. ncbi What made sesquiterpene lactones reach cancer clinical trials?
    Akram Ghantous
    Biology Department, American University of Beirut, Beirut, Lebanon
    Drug Discov Today 15:668-78. 2010
    Sesquiterpene lactones (SLs) are plant-derived compounds often used in traditional medicine against inflammation and cancer...
  39. pmc Production of acylated homoserine lactones by psychrotrophic members of the Enterobacteriaceae isolated from foods
    L Gram
    Danish Institute for Fisheries Research, Department of Seafood Research, Technical University of Denmark, DK 2800 Lyngby, Denmark
    Appl Environ Microbiol 65:3458-63. 1999
    ..This level of Enterobacteriaceae is often found in lightly preserved foods, and AHL-mediated gene regulation may play a role in bacteria associated with food spoilage or food toxicity...
  40. pmc Quorum quenching by an N-acyl-homoserine lactone acylase from Pseudomonas aeruginosa PAO1
    Charles F Sio
    Pharmaceutical Biology, University Centre for Pharmacy, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Infect Immun 74:1673-82. 2006
    ..The quorum-quenching AHL acylase may enable P. aeruginosa PAO1 to modulate its own quorum-sensing-dependent pathogenic potential and, moreover, offers possibilities for novel antipseudomonal therapies...
  41. pmc Chemotaxis to the quorum-sensing signal AI-2 requires the Tsr chemoreceptor and the periplasmic LsrB AI-2-binding protein
    Manjunath Hegde
    3122 TAMU, Texas A and M University, College Station, TX 77843 3122, USA
    J Bacteriol 193:768-73. 2011
    ..We show that AI-2 strongly attracts Escherichia coli. Both LsrB and Tsr are necessary for sensing AI-2, but AI-2 uptake is not, suggesting that LsrB and Tsr interact directly in the periplasm...
  42. ncbi Potent antifouling resorcylic acid lactones from the gorgonian-derived fungus Cochliobolus lunatus
    Chang Lun Shao
    Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People s Republic of China
    J Nat Prod 74:629-33. 2011
    Three new 14-membered resorcylic acid lactones, two with a rare natural acetonide group and one with a 5-chloro-substituted lactone, named cochliomycins A-C (1-3), together with four known analogues, zeaenol (4), LL-Z1640-1 (5), LL-Z1640-..
  43. pmc The quest for universal access to effective malaria treatment: how can the AMFm contribute?
    Lloyd Matowe
    The Global Fund to Fight AIDS, Tuberculosis and Malaria, AMFm Unit, Chemin de Blandonnet 8, 1214 Vernier, Geneva, Switzerland
    Malar J 9:274. 2010
    ..This paper examines, within access to medicines frameworks, the role of the AMFm across and within each dimension and discusses how the AMFm can help to solve access bottlenecks...
  44. ncbi Two cutinase-like proteins secreted by Mycobacterium tuberculosis show very different lipolytic activities reflecting their physiological function
    Mathieu Schue
    Centre National de la Recherche Scientifique, Aix Marseille Universite, Enzymologie Interfaciale et Physiologie de la Lipolyse UPR 9025, Marseille, France
    FASEB J 24:1893-903. 2010
    ..Our findings open new prospects for investigating the physiological roles of cutinase-like proteins in the lipid metabolism and virulence of M. tuberculosis...
  45. pmc Roles for auxin, cytokinin, and strigolactone in regulating shoot branching
    Brett J Ferguson
    School of Integrative Biology and Australian Research Council Centre of Excellence for Integrative Legume Research, University of Queensland, St Lucia, Queensland 4072, Australia
    Plant Physiol 149:1929-44. 2009
    ....
  46. ncbi Bacterial cell-to-cell communication: sorry, can't talk now - gone to lunch!
    Klaus Winzer
    Institute of Infections and Immunity, University of Nottingham, Queen s Medical Centre, NG7 2UH, Nottingham, United Kingdom
    Curr Opin Microbiol 5:216-22. 2002
    ..This depends on rigorous chemical characterisation and demonstration that the molecule controls cellular responses beyond those required to metabolise or detoxify the signal...
  47. pmc Quorum sensing in Escherichia coli, Salmonella typhimurium, and Vibrio harveyi: a new family of genes responsible for autoinducer production
    M G Surette
    Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive, North West, Calgary, Alberta, T2N 4N1, Canada
    Proc Natl Acad Sci U S A 96:1639-44. 1999
    ..coli DH5alpha luxSE.c. gene shows that it contains a frameshift mutation resulting in premature truncation of the LuxSE.c. protein. Our results indicate that the luxS genes define a new family of autoinducer-production genes...
  48. ncbi Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms
    Siyuan Zhang
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Republic of Singapore
    Curr Med Chem Anticancer Agents 5:239-49. 2005
    Sesquiterpene lactones (SLs) are the active constituents of a variety of medicinal plants used in traditional medicine for the treatment of inflammatory diseases...
  49. pmc Structure-activity relationship of cinnamaldehyde analogs as inhibitors of AI-2 based quorum sensing and their effect on virulence of Vibrio spp
    Gilles Brackman
    Laboratory of Pharmaceutical Microbiology, Ghent University, Ghent, Belgium
    PLoS ONE 6:e16084. 2011
    ..However, little is known about the structure-activity relationship of cinnamaldehyde analogs...
  50. pmc Small-molecule inhibitor binding to an N-acyl-homoserine lactone synthase
    Jiwoung Chung
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Proc Natl Acad Sci U S A 108:12089-94. 2011
    ..In gram-negative bacteria, QS is often mediated by N-acyl-L-homoserine lactones (acyl-HSLs)...
  51. ncbi Molecular insights into quorum sensing in the human pathogen Pseudomonas aeruginosa from the structure of the virulence regulator LasR bound to its autoinducer
    Matthew J Bottomley
    Istituto di Ricerche di Biologia Molecolare, Via Pontina Km 30 600, 00040 Pomezia, Rome, Italy
    J Biol Chem 282:13592-600. 2007
    ..The structure also provides a platform for the optimization, or de novo design, of quorum sensing inhibitors...
  52. ncbi Antiparasitic activities of two sesquiterpenic lactones isolated from Acanthospermum hispidum D.C
    Habib Ganfon
    Pharmacognosy Research Group, Louvain Drug Research Institute, Universite Catholique de Louvain, Avenue E Mounier B1 72 03, B 1200 Brussels, Belgium
    J Ethnopharmacol 141:411-7. 2012
    ..Aerial parts of Acanthospermum hispidum D.C. are often used by traditional healers in Benin for various diseases and especially for malaria...
  53. ncbi Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction
    Muhammad Khan
    Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun, People s Republic of China
    IUBMB Life 64:783-94. 2012
    ..Therefore, alantolactone may become a potential lead compound for future development of antiglioma therapy...
  54. ncbi Ginkgolide B reduces inflammatory protein expression in oxidized low-density lipoprotein-stimulated human vascular endothelial cells
    Shan Zhang
    Department of Immunology, Beijing Institute of Geriatrics, Beijing Hospital and Key Laboratory of Geriatrics Ministry of Health, Beijing, China
    J Cardiovasc Pharmacol 57:721-7. 2011
    ..It seems that ginkgolide B possesses some pharmacological action on intracellular oxidative stress in association with the downregulation of Nox4 expression...
  55. pmc Complete genome sequence of Burkholderia sp. Strain GG4, a betaproteobacterium that reduces 3-oxo-N-acylhomoserine lactones and produces different N-acylhomoserine lactones
    Kar Wai Hong
    Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia
    J Bacteriol 194:6317. 2012
    ..To the best of our knowledge, this is the first sequenced genome from a bacterium of the genus Burkholderia that shows both quorum-sensing and signaling confusion activities...
  56. ncbi Chlorogenic acids from Tithonia diversifolia demonstrate better anti-inflammatory effect than indomethacin and its sesquiterpene lactones
    Daniela Aparecida Chagas-Paula
    Faculdade de Ciências Farmacêuticas de Ribeirão Preto FCFRP, Universidade de Sao Paulo USP, Departamento de Ciências Farmacêuticas Av Café s no, Monte Alegre, 14040 903 Ribeirao Preto, SP, Brazil
    J Ethnopharmacol 136:355-62. 2011
    ....
  57. pmc Regulation of uptake and processing of the quorum-sensing autoinducer AI-2 in Escherichia coli
    Karina B Xavier
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 187:238-48. 2005
    ..These findings show that, depending on the prevailing growth conditions, the amount of time that the AI-2 signal is present and, in turn, the time that a given community of bacteria remains exposed to this signal can vary greatly...
  58. ncbi Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells
    Jen Yu Hung
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Lung Cancer 68:355-65. 2010
    ..This study demonstrates that DHE may be a novel anticancer agent for the treatment of non-small cell lung cancer...
  59. pmc Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
    Andres F Gonzalez Barrios
    Dept of Chemical Engineering, University of Connecticut, 191 Auditorium Road, Storrs, CT 06269 3222, USA
    J Bacteriol 188:305-16. 2006
    ..Together, these results indicate AI-2 induces biofilm formation in E. coli through B3022, which then regulates QseBC and motility; hence, b3022 has been renamed the motility quorum-sensing regulator gene (the mqsR gene)...
  60. ncbi Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones
    Thomas J Schmidt
    Institut für Pharmazeutische Biologie der Heinrich Heine Universität, Dusseldorf, Germany
    Planta Med 68:750-1. 2002
    The anti-trypanosomal activity of six sesquiterpene lactones (helenalin, mexicanin I, 11alpha,13-dihydrohelenalin acetate, chamissonolide, ivalin and isoalantolactone) against the African Trypanosoma brucei rhodesiense and American T...
  61. ncbi Pre-attachment Striga hermonthica resistance of New Rice for Africa (NERICA) cultivars based on low strigolactone production
    Muhammad Jamil
    Laboratory of Plant Physiology, Wageningen University, PO Box 658, 6700 AR Wageningen, The Netherlands
    New Phytol 192:964-75. 2011
    ....
  62. ncbi Engineered biological nanofactories trigger quorum sensing response in targeted bacteria
    Rohan Fernandes
    Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA
    Nat Nanotechnol 5:213-7. 2010
    ..We envision the use of these nanofactories in generating new antimicrobial treatments that target the communication networks of bacteria rather than their viability...
  63. ncbi Alantolactone inhibits cell proliferation by interrupting the interaction between Cripto-1 and activin receptor type II A in activin signaling pathway
    Ying Shi
    National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun, 130024, China
    J Biomol Screen 16:525-35. 2011
    ..Moreover, screening for inhibitors of Cripto-1/ActRII is a potentially beneficial approach to aid in discovering novel cancer treatment...
  64. ncbi Alantolactone induces apoptosis in chronic myelogenous leukemia sensitive or resistant to imatinib through NF-κB inhibition and Bcr/Abl protein deletion
    Wei Wei
    Department of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, No 197, Ruijin Er Road, Shanghai, 200025, China
    Apoptosis 18:1060-70. 2013
    ..Collectively, these findings suggest that alantolactone is a promising potent agent to fight against CML cells via the inhibition of the NF-κB signaling pathway and depletion of the Bcr/Abl protein...
  65. pmc Bacterial small-molecule signaling pathways
    Andrew Camilli
    Howard Hughes Medical Institute, 136 Harrison Avenue, Boston, MA 02111 1817, USA
    Science 311:1113-6. 2006
    ..We suggest how these two pathways may converge to control complex processes including multicellularity, biofilm formation, and virulence. We also outline new questions that have arisen from recent studies in these fields...
  66. ncbi Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones
    Yong Yao
    Department of Molecular Biology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Mol Biol 355:262-73. 2006
    ..coli expression system, whereas in the absence of acyl homoserine lactones, the protein is expressed into insoluble inclusion bodies...
  67. ncbi Strigolactones promote nodulation in pea
    Eloise Foo
    School of Plant Science, University of Tasmania, Private Bag 55, Hobart, TAS, 7001, Australia
    Planta 234:1073-81. 2011
    ....
  68. pmc Strigolactones as germination stimulants for root parasitic plants
    Koichi Yoneyama
    Weed Science Center, Utsunomiya University, 350 Mine machi, Utsunomiya, 321 8505 Japan
    Plant Cell Physiol 51:1095-103. 2010
    ..In this review, we focus on SLs as germination stimulants for root parasitic plants. In addition, we discuss how quantitative and qualitative differences in SL exudation among sorghum cultivars influence their susceptibility to Striga...
  69. ncbi Gamma-caprolactone stimulates growth of quorum-quenching Rhodococcus populations in a large-scale hydroponic system for culturing Solanum tuberosum
    Amélie Cirou
    Centre National de la Recherche Scientifique, Institut des Sciences du Vegetal, Gif sur Yvette, France
    Res Microbiol 162:945-50. 2011
    ..Most of the assayed Rhodococcus isolates exhibited efficient biocontrol activity for protecting potato tubers. Analytical chemistry approach revealed the rapid degradation of GCL introduced in the plant cultures...
  70. ncbi Strigolactones interact with ethylene and auxin in regulating root-hair elongation in Arabidopsis
    Yoram Kapulnik
    Institute of Plant Sciences, Agricultural Research Organization, The Volcani Center, PO Box 6, Bet Dagan 50250, Israel
    J Exp Bot 62:2915-24. 2011
    ..The ethylene pathway requirement for the RH response to SLs suggests that ethylene forms a cross-talk junction between the SL and auxin pathways...
  71. ncbi Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors
    Sabine Grosch
    Pharmazentrum Frankfurt, ZAFES, Institut fur Klinische Pharmakologie, Klinikum der Johann Wolfgang Goethe, Universitat Frankfurt, Theodor Stern Kai 7, Frankfurt Main, Germany
    J Natl Cancer Inst 98:736-47. 2006
    ..We also compare the concentrations of these inhibitors used in in vitro and in vivo experiments and discuss the implications of the in vitro studies for clinical management of cancer with these drugs...
  72. ncbi Diverse roles of strigolactones in plant development
    Philip B Brewer
    School of Biological Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Mol Plant 6:18-28. 2013
    ..This hormonal response is a key adaption that radically alters whole-plant architecture in order to optimize growth and development under diverse environmental conditions...
  73. ncbi Temporal regulation of enterohemorrhagic Escherichia coli virulence mediated by autoinducer-2
    Tarun Bansal
    Artie McFerrin Department of Chemical Engineering, Texas A and M University, 222 Jack E Brown Engineering Building, 3122 TAMU, College Station, TX 77843 3122, USA
    Appl Microbiol Biotechnol 78:811-9. 2008
    ..Our results suggest that AI-2 is an important signal in EHEC infections of the human GI tract...
  74. pmc Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors
    Carlos Solorzano
    Department of Pharmacology, University of California, Irvine, 360 MSRII, Irvine, California 92697 4625, USA
    J Med Chem 53:5770-81. 2010
    ..Starting from the structure of 7a, a series of beta-lactones was prepared and tested on recombinant rat NAAA to explore structure-activity relationships (SARs) for this class ..
  75. ncbi Structural identification of a bacterial quorum-sensing signal containing boron
    Xin Chen
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nature 415:545-9. 2002
    ..Furthermore, they indicate a potential biological role for boron, an element required by a number of organisms but for unknown reasons...
  76. ncbi Antitrypanosomal sesquiterpene lactones from Saussurea costus
    Tasqiah Julianti
    Division of Pharmaceutical Biology, University of Basel, CH 4056 Basel, Switzerland
    Fitoterapia 82:955-9. 2011
    ..Subsequent HPLC based activity profiling led to the identification of the sesquiterpene lactones arbusculin B (1), α-cyclocostunolide (2), costunolide (3), and dehydrocostuslactone (4)...
  77. ncbi Dual modes of modification of hepatitis A virus 3C protease by a serine-derived beta-lactone: selective crystallization and formation of a functional catalytic triad in the active site
    Jiang Yin
    CIHR Group in Protein Structure and Function, Department of Biochemistry, University of Alberta, Edmonton, Alberta, Canada T6G 2H7
    J Mol Biol 354:854-71. 2005
    ..The success of soaking IVF into HAV 3C-1a crystals demonstrates the usefulness of this new crystal form in the study of enzyme-inhibitor interactions in the proteolytic active site...
  78. ncbi Synaptic protein degradation underlies destabilization of retrieved fear memory
    Sue Hyun Lee
    National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, San 56 1 Silim dong, Gwanak Gu, Seoul 151 747, Korea
    Science 319:1253-6. 2008
    ..It also provides strong evidence for the existence of reorganization processes whereby preexisting memory is disrupted by protein degradation, and updated memory is reconsolidated by protein synthesis...
  79. ncbi LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing
    Ting Xue
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
    Cell Res 19:1258-68. 2009
    ..Furthermore, in agreement with the conclusion that phosphorylated AI-2 can relieve the repression of LsrR in previous studies, our data show that phospho-AI-2 renders LsrR unable to bind to its own promoter in vitro...
  80. ncbi Acetogenins from Annonaceae: recent progress in isolation, synthesis and mechanisms of action
    Almudena Bermejo
    Laboratoire de Pharmacognosie, associe au CNRS BIOCIS, Faculte de Pharmacie, Universite Paris Sud, 92296, Chatenay Malabry, France
    Nat Prod Rep 22:269-303. 2005
    ..In fact, of the 417 isolated compounds reviewed, over 176 have been added during the period from 1998 to 2004...
  81. ncbi Chemistry. The renaissance of natural products as drug candidates
    Ian Paterson
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Science 310:451-3. 2005
  82. ncbi Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial
    Robert S Bresalier
    Department of Gastrointestinal Medicine and Nutrition, University of Texas M D Anderson Cancer Center, Houston 77030 4009, USA
    N Engl J Med 352:1092-102. 2005
    ....
  83. ncbi Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase
    Olga Khersonsky
    Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
    Biochemistry 44:6371-82. 2005
    ..performed with three groups of substrates that are known to be hydrolyzed by PON1: phosphotriesters, esters, and lactones. We found that the hydrolysis of aryl esters is governed primarily by steric factors and not the pK(a) of the ..
  84. ncbi Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids
    F Catella-Lawson
    University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 289:735-41. 1999
    ..Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1...
  85. ncbi Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
    C Cavin
    Quality and Safety Department, Nestle Research Center, P O Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 327:742-9. 2005
    ..Altogether, the data presented strongly support chicory root as a promising source of functional food ingredient, combining prebiotic and anti-inflammatory properties...
  86. ncbi A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase
    Hui Hong
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK
    Chembiochem 6:643-8. 2005
  87. pmc Antagonistic action of strigolactone and cytokinin in bud outgrowth control
    Elizabeth A Dun
    University of Queensland, School of Biological Sciences, St Lucia, Queensland, 4072 Australia
    Plant Physiol 158:487-98. 2012
    ....
  88. pmc New target for inhibition of bacterial RNA polymerase: 'switch region'
    Aashish Srivastava
    Howard Hughes Medical Institute, Waksman Institute, and Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, NJ 08854, USA
    Curr Opin Microbiol 14:532-43. 2011
    ..This review summarizes the switch region, switch-region inhibitors, and implications for antibacterial drug discovery...
  89. pmc Sinorhizobium meliloti, a bacterium lacking the autoinducer-2 (AI-2) synthase, responds to AI-2 supplied by other bacteria
    Catarina S Pereira
    Bacterial Signaling Laboratory, Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Mol Microbiol 70:1223-35. 2008
    ..Our findings suggest that S. meliloti is capable of 'eavesdropping' on the AI-2 signalling of other species and interfering with AI-2-regulated behaviours such as virulence...
  90. pmc Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence
    Liping Zhao
    Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China
    Infect Immun 78:3506-15. 2010
    ..aureus. This regulation occurred via the phosphorylation of KdpE binding to the cap promoter...
  91. ncbi Recent developments in ring opening polymerization of lactones for biomedical applications
    Ann Christine Albertsson
    Department of Fibre and Polymer Technology, The Royal Institute of Technology, S 10044 Stockholm, Sweden
    Biomacromolecules 4:1466-86. 2003
    Aliphatic polyesters prepared by ring-opening polymerization of lactones are now used worldwide as bioresorbable devices in surgery (orthopaedic devices, sutures, stents, tissue engineering, and adhesion barriers) and in pharmacology (..
  92. ncbi Structure and function of natural and synthetic signalling molecules in parasitic weed germination
    Binne Zwanenburg
    Department of Organic Chemistry, Institute for Molecules and Materials, Radboud University Nijmegen, AJ Nijmegen, The Netherlands
    Pest Manag Sci 65:478-91. 2009
    ....
  93. ncbi Analysis of agricultural commodities and foods for Alternaria mycotoxins
    P M Scott
    Health Canada, Health Products and Food Branch, Food Research Division, Sir Frederick G Banting Research Centre, Ottawa, ON
    J AOAC Int 84:1809-17. 2001
    ..They have been found also in processed fruit products such as apple juice, other fruit beverages and tomato products, wheat and other grains, sunflower seeds, oilseed rape meal, and pecans...
  94. ncbi Synthesis of multiple N-acylhomoserine lactones is wide-spread among the members of the Burkholderia cepacia complex
    A Gotschlich
    Lehrstuhl fur Mikrobiologie, Technische Universitat Munchen, Germany
    Syst Appl Microbiol 24:1-14. 2001
    ....
  95. pmc Three parallel quorum-sensing systems regulate gene expression in Vibrio harveyi
    Jennifer M Henke
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Bacteriol 186:6902-14. 2004
    ..Together these communication systems act as a three-way coincidence detector in the regulation of a variety of genes, including those responsible for bioluminescence, type III secretion, and metalloprotease production...
  96. ncbi Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria
    Karina B Xavier
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544 1014, USA
    ACS Chem Biol 2:128-36. 2007
    ..This series of chemical events is proposed to enable enteric bacteria to respond to the presence of competitor bacteria by sequestering and destroying AI-2, thereby eliminating the competitors' intercellular communication capabilities...
  97. pmc Quorum sensing in Escherichia coli is signaled by AI-2/LsrR: effects on small RNA and biofilm architecture
    Jun Li
    Center for Biosystems Research, University of Maryland Biotechnology Institute, College Park, MD 20742, USA
    J Bacteriol 189:6011-20. 2007
    ..Our results suggest that AI-2 is indeed a QS signal in E. coli, especially when it acts through the transcriptional regulator LsrR...
  98. ncbi Diffusible signals and interspecies communication in bacteria
    Robert P Ryan
    BIOMERIT Research Centre, Department of Microbiology, Biosciences Institute, National University of Ireland, Cork, Ireland
    Microbiology 154:1845-58. 2008
    ..Here we review our current understanding of interspecies signalling in bacteria and the signals involved, what is known of the underlying signal transduction mechanisms and their influences on bacterial behaviour...
  99. ncbi Memory reconsolidation mediates the strengthening of memories by additional learning
    Jonathan L C Lee
    School of Psychology, University of Birmingham, Edgbaston, Birmingham, UK
    Nat Neurosci 11:1264-6. 2008
    ..I found that one normal function of hippocampal memory reconsolidation in rats is to modify the strength of a contextual-fear memory as a result of further learning...
  100. ncbi XENical in the prevention of diabetes in obese subjects (XENDOS) study: a randomized study of orlistat as an adjunct to lifestyle changes for the prevention of type 2 diabetes in obese patients
    Jarl S Torgerson
    Department of Body Composition and Metabolism, Sahlgrenska University Hospital, Goteborg, Sweden
    Diabetes Care 27:155-61. 2004
    ..We hypothesized that adding a weight-reducing agent to lifestyle changes may lead to an even greater decrease in body weight, and thus the incidence of type 2 diabetes, in obese patients...
  101. ncbi Annonacin, a natural mitochondrial complex I inhibitor, causes tau pathology in cultured neurons
    Myriam Escobar-Khondiker
    Experimental Neurology, Philipps University, D 35033 Marburg, Germany
    J Neurosci 27:7827-37. 2007
    ....

Research Grants62

  1. Bacterial Immunosuppression: Host Target Identification Through Chemical Probes
    Kim D Janda; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In Gram-negative bacteria N-acyl-L-homoserine lactones (AHLs) are produced as quorum-sensing (QS) signaling molecules to promote multicellularity and virulence...
  2. Re-Wiring Cellular Metabolism to Control Biofilm Formation and Virulence BY...
    Thomas K Wood; Fiscal Year: 2011
    ..We have recently discovered that E. coli and pseudomonads respond to signals they do not synthesize (homoserine lactones influence E...
  3. INTERACTIONS BETWEEN AGROBACTERIUM AND HOST PLANTS
    Stephen C Winans; Fiscal Year: 2010
    ..Among these signals, acyl-homoserine lactones (AHLs) are especially widespread among the proteobacteria...
  4. Bacterial Quorum Sensing as Target for Anti-Infective Immunotherapy
    Bin Zhou; Fiscal Year: 2013
    ..such as Vibrio fischeri and Pseudomonas aeruginosa, employ small diffusible molecules, namely N-acyl homoserine lactones, to globally regulate the production of secondary metabolites and proteins, initiated a new area in ..
  5. Altered Hepatic Disposition of Statins by Diabetes Mellitus
    Fatemeh Akhlaghi; Fiscal Year: 2012
    ..Recently, we have observed significantly higher concentrations of atorvastatin (ATV) lactones in patients with diabetes mellitus...
  6. Chemical Tools to Delineate the Pseudomonas aeruginosa Quorum Sensing Circuit
    Nora R Eibergen; Fiscal Year: 2013
    ..bacteria, this QS process is largely driven by the detection of structurally distinct N-acylated L- homoserine lactones (AHLs)...
  7. Eukaryotic Perception of Prokaryotic Quorum Signals
    ANDREW GEORGE PALMER; Fiscal Year: 2010
    ..The best characterized Als are the N-acylated L-homoserine lactones (AHLs) utilized by Gram-negative bacteria...
  8. Studies of bacterial autoinducers:recognition and modulation of host processes
    Vladimir V Kravchenko; Fiscal Year: 2012
    ..field of host-pathogen interactions mediated by quorum sensing signaling molecules (QSSM), namely acyl homoserine lactones (AHLs)...
  9. SYNTHESIS OF PHOSPHATE ESTERS WITH IODINE--III REAGENTS
    GERALD KOSER; Fiscal Year: 1990
    ..is provided by a ribonucleotide and the direct incorporation of the ribonucleotide into ketones (alpha-carbon), lactones etc. will also be investigated...
  10. Efficient Assemblage of Complex Biologically-Active Targets Using Donor-Acceptor
    KEITH THOMAS MEAD; Fiscal Year: 2012
    ..are geminally substituted with ester and diethoxyphosphoryl groups and study their rearrangement to ?-phosphono-?-lactones. Applied to a chiral 2H-chromene substrate, this method will be used to complete the first enantioselective ..
  11. Developing Inhibitors of LuxS-dependent Quorum Sensing Systems in Oral Bacteria
    Chunhao Li; Fiscal Year: 2013
    ..There are two major types of AIs, AI-1 and AI-2. AI-1 includes acylated homoserine lactones and modified peptides, which serve as intra-species signaling molecules...
  12. Salinosporamide Biosynthesis and Engineering
    Bradley S Moore; Fiscal Year: 2013
    ..a streamlined chemoenzymatic synthesis of salinosporamide derivatives based on a focused library of ?-lactam-?-lactones from synthetic acylamino acid thioesters with recombinant salinosporamide biosynthetic enzymes...
  13. REACTIVITY MODELS FOR ISOPENICILLIN N SYNTHETASE
    PATRICIA SHAPLEY; Fiscal Year: 1992
    ..elimination form coordinated cysteine to the metal, (3) to induce the formation of beta-lactams and beta-lactones at the metal center, and (4) to prepare oxo-iron alkyls and study chemical reactions resulting in Fe-C homolysis ..
  14. b-Lactones: Bioactive Target and Vehicles for Synthesis
    Daniel Romo; Fiscal Year: 2010
    This proposal seeks to exploit diastereoselective routes to bicyclic--lactones to access antitumor, antibacterial and anti-inflammatory agents of interest for human health and as tools for studying basic biological processes...
  15. Enantioselective Total Synthesis of Marcfortine B via SmI2-mediated C-C Bond Form
    TIMOTHY KUM BENG; Fiscal Year: 2013
    ..Macrocyclic lactones, benzimidazoles, and imidazothiazoles are at present being used for the eradication of gastrointestinal nematodes ..
  16. Chemical Strategies to Manipulate A1-2 Signaling in Bacterial Pathogens
    Kim D Janda; Fiscal Year: 2013
    ..g. oligopeptides and acyl homoserine lactones, have been identified as autoinducers...
  17. Enantioselective Thiourea-Catalyzed Syntheses of beta-Lactones and beta-Lactams
    PAMELA MICHELE TADROSS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Lactones and -lactams are structural motifs critical to the treatment of disease and infection whose activity is directly related to the highly strained 4-membered ring present in each...
  18. Quorum Sensing in Sinorhizobium meliloti
    Juan Gonzalez; Fiscal Year: 2009
    ..The best characterized of these autoinducers are acylated homoserine lactones (AHLs), mostly found in gram-negative organisms...
  19. 3rd ASM Conference on Cell-Cell Communication in Bacteria
    WILLIAM FUQUA; Fiscal Year: 2007
    ..systems such as the cyclic oligopeptide signals that regulate Staphylococcus aureus virulence and acyl homoserine lactones (AHLs) that control of pathogenesis in Pseudomonas aeruginosa are now joined by a number of more recently ..
  20. Phoslactomycins: Biosynthesis &Activity
    Kevin A Reynolds; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): A number of bacterial natural products contain substituted ???-unsaturated-?-lactones. The chemical nature of the substituents alters the biological activity considerably...
  21. Phoslactomycins: Biosynthesis & Activity
    Kevin A Reynolds; Fiscal Year: 2010
    A number of bacterial natural products contain substituted a,B-unsaturated-dlactones. The chemical nature of the substituents alters the biological activity considerably...
  22. The Role of Statin Lactones in Statin Toxicity
    Uwe Christians; Fiscal Year: 2006
    ..both acid and lactone form exists in vivo, very little attention has been paid to the potential role of the lactones of statins administered as open acids (atorvastatin, cerivastatin, fluvastatin, pravastatin) in pharmacokinetic ..
  23. Synthesis of Potentially Bioactive Peroxides by Electrophilic Activation
    SHELLI WAETZIG; Fiscal Year: 2009
    ..2. Develop nucleophilic opening of ([unreadable]-lactones for the preparation of cyclic, functionalized peroxides...
  24. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    ..inhibitors of CE, and (2) to use versatile schemes described in this proposal for the synthesis of haloenol lactones such as substituted 4-chloroisocoumarins as potential irreversible inhibitors of cholesterol esterase...
  25. Endectocides for Malaria Control
    Brian Foy; Fiscal Year: 2009
    ..determine the effective doses of glutamate and GABA-gated chloride ion channel agonist endectocides (macrocyclic lactones, milbemycins, nodulasporamides) for killing adult Anopheles spp. when administered via an artificial bloodmeal...
  26. NEW METHODS FOR ACYCLIC CONFORMATIONAL CONTROL
    David Shultz; Fiscal Year: 2000
    ..We will extend this investigation to the synthesis of medium sized lactones, and carbocycles to lactonization and aldol reactions, respectively...
  27. Generating antibodies against N-Acyl homoserine lactones
    Kim Janda; Fiscal Year: 2004
    The discovery that Gram-negative bacteria employ small molecules, namely N-acyl homoserine lactones (AHLs), to globally regulate the production of secondary metabolites and control the expression of virulence determinants has provided a ..
  28. ENZYME-ACTIVATED IRREVERSIBLE INHIBITORS OF PROTEASES
    John Katzenellenbogen; Fiscal Year: 1990
    ..We have previously prepared halo enol lactones that appear to act, through a two-step acylation- alkylation sequence, as mechanism-based inactivators of the ..
  29. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2002
    ..sensing depends upon the secretion and sensing of species-specific nonpolar signal molecules (acyl homoserine lactones, acyl-HSLs) that arise from the metabolism of methionine...
  30. QUORUM SENSING IN HUMAN CELLS
    BRUCE DOLNICK; Fiscal Year: 2003
    ..sensing depends upon the secretion and sensing of species-specific nonpolar signal molecules (acyl homoserine lactones, acyl-HSLs) that arise from the metabolism of methionine...
  31. Feverfew and Parthenolide in Mouse Models of CF
    Melvin Berger; Fiscal Year: 2005
    ..Studies which have primarily been done in cell cultures have shown that parthenolide and other sesquiterpene lactones in feverfew extracts may have anti-inflammatory effects mediated by inhibiting the signaling enzyme I-kappa- ..
  32. Cocaine-induced planarian behavior and its modulation by sesquiterpene lactones
    ONE PAGAN; Fiscal Year: 2009
    ..The information that will be obtained from the proposed experiments will provide novel directions in the search for substances that may serve as anti-cocaine agents. ..
  33. Synthetic Approaches to Blepharocalyxins D and E
    KEITH MEAD; Fiscal Year: 2003
    ..The main body of this proposal will focus on the stereoselective synthesis of cis-fused dioxabicyclic lactones (6,6- and 6,5-fused) and their subsequent use, through ring opening substitution reactions, in the ..
  34. CHIRAL CATALYSTS FOR ENANTIOSELECTIVE SYNTHESES
    Michael Doyle; Fiscal Year: 2002
    ..that have been used for the construction of lignans, 2-deoxyxylolactone, and a variety of lactones and lactams in high enantiomeric excess (94 percent or more ee) with exceptional diastereo-, regio-, and ..
  35. ASYMMETRIC REACTIONS OF PROCHIRAL KETONES
    JEFFREY AUBE; Fiscal Year: 1992
    ..A scheme for the synthesis of optically active lactones is based on a synthetic equivalent of an asymmetric Beckmann rearrangement...
  36. NOVEL ANTICANCER FATTY ACID SYNTHASE INHIBITORS
    Daniel Romo; Fiscal Year: 2007
    ..The recent finding by the Smith group that certain beta-lactones (2-oxetanones, e.g...
  37. Novel Anti-quorum Sensing Agent
    JAMES LARRICK; Fiscal Year: 2002
    DESCRIPTION (Provided by applicant): The opportunistic human pathogen P. aeruginosa utilizes N-acylhomoserine lactones as quorum sensing "autoinducers" to specifically induce numerous virulence genes...
  38. Quorum sensing, bacterial interaction and disease
    Naomi Balaban; Fiscal Year: 2004
    ..quorum sensing mechanisms, through the secretion of signaling organic molecules such as derivatives of homoserine lactones in Gram-negative bacteria and proteins and peptides in Gram-positive bacteria to activate or suppress functions ..
  39. SYNTHESIS OF BIOACTIVE MACROLIDES
    James White; Fiscal Year: 2002
    ..chemical structures towards which this synthetic effort is directed are naturally occurring macrocyclic lactones (macrolides), all of which possess striking biological properties of potential chemotherapeutic value...
  40. ONCOGENE DIRECTED SYNTHESIS OF CEPHALOSTATIN CANCER DRUG
    Philip Fuchs; Fiscal Year: 2004
    ..This will be accomplished by systematic exploration of the potential of a previously unknown stereospecific dyatropic rearrangement of beta-hydroxyketones and beta-hydroxy lactones to accomplish this transformation.
  41. Total Synthesis of Polygaloides A & B
    ERICK IEZZI; Fiscal Year: 2005
    Polygalolides A and B are new phenolic lactones that were recently isolated from Polygala fallax, which is a medicinal plant that is found off the southern mainland of China...
  42. SYNTHESIS OF THE PODOCARPUS DILACTONES
    ROBERT WOLLENBERG; Fiscal Year: 1980
    ..Recent studies have also revealed a strong cytotoxicity against Yoshida sarcoma for several of these lactones. In addition, many of these substances show novel plant growth inhibitory properties...
  43. Detection of Mixed Microbial Communities by Salmonella
    BRIAN AHMER; Fiscal Year: 2004
    ..The signaling event discovered is the detection of N-acylhomoserine lactones (AHLs) by SdiA, a LuxR homolog found in S. typhimurium. The sdiA gene is also present in E...
  44. Bacterial AHL interactions with nuclear receptors
    BARRY FORMAN; Fiscal Year: 2005
    ..Gram-negative bacteria release small molecules called acyl homoserine lactones (AHLs) into the surrounding environment to communicate within and between species...
  45. Camptothecin Analogs for Cancer Therapy
    LEE MORGAN; Fiscal Year: 2007
    ..These CPT analogs are lactones that have increased activity in acidic hypoxia tissues, characteristic of fast growing cancers that ..
  46. Metal-Catalyzed Asymmetric Arylation of Silyloxy Dienes
    Lei Jiang; Fiscal Year: 2004
    Optically pure gamma-aryl lactones and gamma-aryl lactams are general structural subunits in many biologically active natural products and pharmacologically important molecules...
  47. Small Molecule Inhibitor of Quorum Sensing
    Susan Wright; Fiscal Year: 2004
    The opportunistic human pathogen, Pseudomonas aeruginosa, utilizes acyl-homoserine lactones (acyI-HSL) as quorum sensing autoinducers to activate the expression of numerous virulence genes...
  48. APPLICATIONS OF NEW CYCLOADDITIONS TO DRUG SYNTHESIS
    KENDALL HOUK; Fiscal Year: 1980
    ..in our laboratories will be investigated as means to synthesize anzulenes, hydroazulenes, and sesquiterpene lactones (of potential importance as anti-tumor agents), cyclopentapyridazines (analogs of known anti-neoplastic agents ..
  49. ALLENES IN THE SYNTHESIS OF BIOACTIVE MOLECULES
    JACK CRANDALL; Fiscal Year: 1990
    ..molecules include models for corticoid steroids, pyrrolidine and piperidine alkaloids, sugar, alkylidene lactones, and complex oxygenated tetrahydrofurans and -pyrans...
  50. TOTAL SYNTHESIS OF THE AVERMECTINS A1B AND A2B
    ANTHONY BARRETT; Fiscal Year: 1991
    The avermectins and the structurally related milbemycins are groups of naturally occurring macrocyclic spiro-ketal lactones that are notable as extremely potent parasiticidal agents...
  51. SYNTHESIS OF TRICHOTHECENE LACTONES
    George Kraus; Fiscal Year: 1980
    The total synthesis of verrucarol and several trichothecene lactones is the major goal of this project. The synthetic scheme is a flexible one and should be suitable for the preparation of several analogs...
  52. N-Heterocyclic Carbenes as Organocatalysts
    DARCY CULKIN; Fiscal Year: 2005
    ..A direct extension of this chemistry is the stereoselective ROP (ring-opening polymerization) of cyclic lactones, a polyesterification reaction...
  53. SYNTHESIS VIA REACTIONS OF ENOLATES WITH EPOXIDES
    Kerry Taylor; Fiscal Year: 1990
    ..The synthesis of alpha-methylene gamma-lactones appears to be quite possible by the chemistry described herein...
  54. SYNTHESIS OF TUMOR INHIBITORY COMPOUNDS
    James Marshall; Fiscal Year: 1980
    Synthetic routes of alpha-methylene lactones with possible tumor-inhibitory properties will be examined. Model systems will be used to develop efficient reaction sequences for the basic structural features of natural tumor inhibitors...
  55. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  56. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  57. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  58. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  59. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  60. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..