acetophenones

Summary

Top Publications

  1. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008
  2. pmc A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes
    Meenu Kesarwani
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Pathog 7:e1002192. 2011
  3. pmc Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
    Hai Chen
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cereb Blood Flow Metab 29:1262-72. 2009
  4. ncbi Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols
    David K Johnson
    Department of Chemistry, State University of New York College at Geneseo, USA
    Endothelium 9:191-203. 2002
  5. ncbi Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
  6. ncbi Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
    Elsa C Chan
    Bernard O Brien Institute of Microsurgery, University of Melbourne, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:710-8. 2007
  7. pmc Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Phytomedicine 15:496-503. 2008
  8. ncbi Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Free Radic Res 45:221-36. 2011
  9. pmc Apocynin improves outcome in experimental stroke with a narrow dose range
    X N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroscience 154:556-62. 2008
  10. ncbi Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics
    J Stefanska
    Department of Immunopathology, Medical University of Lodz, Lodz, Poland
    Exp Lung Res 38:90-9. 2012

Research Grants

  1. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
  2. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
  3. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
  4. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
  5. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
  6. MECHANOSENSITIVE MODULATION OF AIRWAY CONTRACTION
    Chi Ming Hai; Fiscal Year: 2008
  7. CDI Molecules & NKT Cells in Host Defense
    RANDY BRUTKIEWICZ; Fiscal Year: 2009
  8. Membrane protein electrophoresis in lipid bilayers
    Mary Wirth; Fiscal Year: 2006
  9. Promiscuous and Specific Inhibitors of Cruzain
    Brian Shoichet; Fiscal Year: 2007
  10. Cerebrovascular Disease in Type 1 Diabetes
    WILLIAM MAYHAN; Fiscal Year: 2007

Detail Information

Publications264 found, 100 shown here

  1. ncbi Apocynin is not an inhibitor of vascular NADPH oxidases but an antioxidant
    Sabine Heumüller
    Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60596 Frankfurt am Main, Germany
    Hypertension 51:211-7. 2008
    ..These observations indicate that apocynin predominantly acts as an antioxidant in endothelial cells and vascular smooth muscle cells and should not be used as an NADPH oxidase inhibitor in vascular systems...
  2. pmc A quorum sensing regulated small volatile molecule reduces acute virulence and promotes chronic infection phenotypes
    Meenu Kesarwani
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS Pathog 7:e1002192. 2011
    ..aeruginosa. We propose that 2-AA mediates changes in a subpopulation of cells that facilitate the exploitation of dynamic host environments and promote gene expression changes that favor chronic infections...
  3. pmc Inhibition of NADPH oxidase is neuroprotective after ischemia-reperfusion
    Hai Chen
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    J Cereb Blood Flow Metab 29:1262-72. 2009
    ..This study suggests that NOX plays a role in oxidative stress and inflammation, thus contributing to ischemic brain injury...
  4. ncbi Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols
    David K Johnson
    Department of Chemistry, State University of New York College at Geneseo, USA
    Endothelium 9:191-203. 2002
    ..These findings identify a metabolite of an ortho-methoxy-substituted catechol, which may be the active compound formed within stimulated ECs that prevents NADPH oxidase complex assembly and activation...
  5. ncbi Apocynin protects against global cerebral ischemia-reperfusion-induced oxidative stress and injury in the gerbil hippocampus
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri Columbia, Columbia, MO 65212, USA
    Brain Res 1090:182-9. 2006
    ....
  6. ncbi Adventitial application of the NADPH oxidase inhibitor apocynin in vivo reduces neointima formation and endothelial dysfunction in rabbits
    Elsa C Chan
    Bernard O Brien Institute of Microsurgery, University of Melbourne, 42 Fitzroy Street, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:710-8. 2007
    ..We have now examined the action of the NADPH oxidase inhibitor apocynin, given via the adventitia, on the neointima formation and endothelial function in this model...
  7. pmc Bioavailability of apocynin through its conversion to glycoconjugate but not to diapocynin
    Qun Wang
    Department of Biochemistry, M743 Medical Sciences Building, University of Missouri, M743 Medical Sciences Building, Columbia, MO 65212, USA
    Phytomedicine 15:496-503. 2008
    ..No diapocynin was detected in any samples. These results indicate rapid glycosylation of apocynin and its transport to blood and other organs but no apparent conversion to diapocynin in vivo...
  8. ncbi Effect of Apocynin, an inhibitor of NADPH oxidase, in the inflammatory process induced by an experimental model of spinal cord injury
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Italy
    Free Radic Res 45:221-36. 2011
    ..Moreover, Apocynin significantly ameliorated the loss of limb function (evaluated by motor recovery score). Thus, it is proposed that Apocynin may be useful in the treatment of inflammation associated with spinal cord trauma...
  9. pmc Apocynin improves outcome in experimental stroke with a narrow dose range
    X N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Neuroscience 154:556-62. 2008
    ..Apocynin at protective doses markedly prevented ischemia-induced increases in O.*. Our data suggested that apocynin can protect against experimental stroke, but with a narrow therapeutic window...
  10. ncbi Apocynin reduces reactive oxygen species concentrations in exhaled breath condensate in asthmatics
    J Stefanska
    Department of Immunopathology, Medical University of Lodz, Lodz, Poland
    Exp Lung Res 38:90-9. 2012
    ..No adverse events have been observed throughout the study. This research confirmed anti-inflammatory properties of nebulized apocynin, which might be an effective and safe drug in bronchial asthma...
  11. ncbi Role of NAD(P)H oxidase on vascular alterations in angiotensin II-infused mice
    Agostino Virdis
    CIHR Multidisciplinary Research Group on Hypertension, Clinical Research Institute of Montreal, University of Montreal, Quebec, Canada
    J Hypertens 22:535-42. 2004
    ..Angiotensin (Ang) II stimulates vascular reactive oxygen species generation via NAD(P)H oxidase activation. We investigated whether vascular NAD(P)H oxidase influences structure and function of resistance arteries from Ang II-infused mice...
  12. pmc Diapocynin and apocynin administration fails to significantly extend survival in G93A SOD1 ALS mice
    Kari A Trumbull
    Linus Pauling Institute, Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR 97331, USA
    Neurobiol Dis 45:137-44. 2012
    ..Diapocynin was also detected in the CNS of apocynin-treated mice. The failure to achieve significant protection with either apocynin or diapocynin raises questions about the utility for treating ALS patients...
  13. ncbi Anti-oxidative effect of apocynin on insulin resistance in high-fat diet mice
    Ran Meng
    Department of Endocrinology, Nanjing Drum Tower Hospital, Nanjing University School of Medicine, 321 Zhongshan Road, Nanjing, 210008, China
    Ann Clin Lab Sci 41:236-43. 2011
    ..These results suggest that apocynin may ameliorate insulin resistance by reducing systemic and hepatic oxidative stress in HFD fed mice...
  14. ncbi Down-regulation of caspase-2 by rottlerin via protein kinase C-delta-independent pathway
    Alakananda Basu
    Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Cancer Res 68:2795-802. 2008
    ..Furthermore, down-regulation of caspase-2 by rottlerin can explain its antiapoptotic function during DNA damage-induced apoptosis...
  15. pmc Comparative pharmacology of chemically distinct NADPH oxidase inhibitors
    S Wind
    Rudolf Buchheim Institute for Pharmacology, Justus Liebig University, Giessen, Germany
    Br J Pharmacol 161:885-98. 2010
    ..One of these sources may be NADPH oxidases. However, due to increasing concerns about the specificity of the compounds commonly used as NADPH oxidase inhibitors, data obtained with these compounds may have to be re-interpreted...
  16. pmc 2-Aminoacetophenone as a potential breath biomarker for Pseudomonas aeruginosa in the cystic fibrosis lung
    Amy J Scott-Thomas
    Christchurch School of Medicine and Health Sciences, Department of Pathology, University of Otago, Christchurch, 8140, New Zealand
    BMC Pulm Med 10:56. 2010
    ..Growth of Ps. aeruginosa releases a "grape-like" odour that has been identified as the microbial volatile organic compound 2-aminoacetophenone (2-AA)...
  17. ncbi Rottlerin sensitizes colon carcinoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via uncoupling of the mitochondria independent of protein kinase C
    David M Tillman
    Division of Molecular Therapeutics, Department of Hematology Oncology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Res 63:5118-25. 2003
    ..Data suggest that rottlerin affects mitochondrial function independent of PKC delta, thereby sensitizing cells to TRAIL, and that mitochondria constitute an important target in overcoming inherent resistance to TRAIL in colon carcinomas...
  18. ncbi Neuroprotective effect of protein kinase C delta inhibitor rottlerin in cell culture and animal models of Parkinson's disease
    Danhui Zhang
    Parkinson s Disorder Research Laboratory, Department of Biomedical Sciences, Iowa Center for Advanced Neurotoxicology, Iowa State University, Ames, IA 50011 1250, USA
    J Pharmacol Exp Ther 322:913-22. 2007
    ....
  19. pmc Small-molecule aggregates inhibit amyloid polymerization
    Brian Y Feng
    Department of Pharmaceutical Chemistry and Graduate Group in Chemistry and Chemical Biology, University of California San Francisco, 1700 4th Street, San Francisco, California 94158 2330, USA
    Nat Chem Biol 4:197-9. 2008
    ..They also blocked infection of yeast cells with Sup35 prions, which suggests that colloidal inhibition may be relevant in more biological milieus...
  20. ncbi NADH/NADPH oxidase and enhanced superoxide production in the mineralocorticoid hypertensive rat
    R A Beswick
    Department of Physiology, Medical College of Georgia, Augusta, USA
    Hypertension 38:1107-11. 2001
    ..These findings suggest that NADPH oxidase is increased and is responsible for increased O(2-) production and possibly contributes to increased blood pressure in the DOCA-salt hypertensive rat...
  21. ncbi Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation
    Edgar A Jaimes
    Nephrology and Hypertension Section, Veterans Affairs Medical Center, Miami, Fla 33125, USA
    Arterioscler Thromb Vasc Biol 24:1031-6. 2004
    ..In these studies, we investigated whether stable compounds present in CS activate specific pathways responsible for the increased endothelial O2* production...
  22. ncbi Rottlerin induces autophagy and apoptotic cell death through a PKC-delta-independent pathway in HT1080 human fibrosarcoma cells: the protective role of autophagy in apoptosis
    Kyoung Sub Song
    Department of Biochemistry, Chungnam National University, Munhwa dong, Joong Gu, Daejeon, Korea
    Autophagy 4:650-8. 2008
    ....
  23. ncbi Apocynin restores endothelial dysfunction in streptozotocin diabetic rats through regulation of nitric oxide synthase and NADPH oxidase expressions
    Murat Olukman
    Department of Pharmacology and Clinical Pharmacology, Faculty of Medicine, Ege University, Bornova, Izmir, Turkey
    J Diabetes Complications 24:415-23. 2010
    ..This study aimed to investigate the effects of apocynin, an NADPH oxidase inhibitor, on endothelial dysfunction and on the expression of NO synthase (NOS) and NADPH oxidase in thoracic aorta of diabetic rats...
  24. ncbi Increased reactive oxygen species contributes to kidney injury in mineralocorticoid hypertensive rats
    L Jin
    Department of Physiology, Medical College of Georgia, Augusta, GA, USA
    J Physiol Pharmacol 57:343-57. 2006
    ..These data suggest that renal injury characteristic of mineralocorticoid hypertension is associated with oxidative stress and is partly independent of blood pressure...
  25. ncbi Apocynin suppresses the progression of atherosclerosis in apoE-deficient mice by inactivation of macrophages
    Hiroyuki Kinoshita
    Department of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto 860 8556, Japan
    Biochem Biophys Res Commun 431:124-30. 2013
    ..Therefore, apocynin may be a potential therapeutic material to prevent the progression of atherosclerosis...
  26. ncbi Apocynin but not allopurinol prevents and reverses adrenocorticotropic hormone-induced hypertension in the rat
    Yi Zhang
    High Blood Pressure Research Unit, John Curtin School of Medical Research, Australian National University, Australian Capital Territory, Canberra, Australia
    Am J Hypertens 18:910-6. 2005
    ..Adrenocorticotropic hormone (ACTH)-induced hypertension in the rat is accompanied by increased oxidative stress. This study examines the enzymatic source of reactive oxygen species in ACTH-hypertension...
  27. ncbi FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway
    Jian Feng Liu
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires, CNRS UPRES A 7053, Universite Paris XII, avenue du General de Gaulle, 94000 Creteil, France
    Biochem Biophys Res Commun 293:1174-82. 2002
    ..These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway...
  28. ncbi Tissue transglutaminase inhibits autophagy in pancreatic cancer cells
    Ugur Akar
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Mol Cancer Res 5:241-9. 2007
    ..In conclusion, these results suggest a novel mechanism of regulation of TG2 and TG2-mediated autophagy in pancreatic cancer cells...
  29. ncbi Potential sources of 2-aminoacetophenone to confound the Pseudomonas aeruginosa breath test, including analysis of a food challenge study
    Amy Scott-Thomas
    Department of Pathology, Christchurch School of Medicine and Health Sciences, University of Otago, PO Box 4345, Christchurch, 8140, New Zealand
    J Breath Res 5:046002. 2011
    ..Analysis of mixed breath samples reported that the levels of 2-aminoacetophenone were immediately elevated after corn chip consumption, but after 2 h the level of 2-aminoacetophenone had reduced back to the 'baseline' for each subject...
  30. ncbi Pro-oxidant activity of apocynin radical
    Lidyane Regina Gomes Castor
    Departamento de Farmacologia, Instituto de Biociencias de Botucatu, Unesp Univ Estadual Paulista, Botucatu, SP, Brasil
    Free Radic Biol Med 48:1636-43. 2010
    ..This characteristic may underlie some of the recent findings regarding beneficial or deleterious effects of the phytochemical...
  31. pmc Effect of protein kinase C delta (PKC-δ) inhibition on the transcriptome of normal and systemic sclerosis human dermal fibroblasts in vitro
    Peter J Wermuth
    Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e27110. 2011
    ..These results indicate that isoform-specific inhibition of PKC-δ profibrotic effects may represent a novel therapeutic approach for SSc and other fibrotic diseases...
  32. ncbi Rottlerin inhibits migration of follicular thyroid carcinoma cells by PKCdelta-independent destabilization of the focal adhesion complex
    Chien Jung Lin
    Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taipei 10051, Taiwan
    J Cell Biochem 110:428-37. 2010
    ..In summary, we demonstrated that rottlerin inhibits the migration of CGTH W-2 cells by disassembly of focal adhesion complexes in a PKCdelta-independent manner, and might play as a mitochondrial uncoupler role in these events...
  33. pmc Apocynin administration does not improve behavioral and neuropathological deficits in a transgenic mouse model of Alzheimer's disease
    Magali Dumont
    Weill Cornell Medical College, Department of Neurology and Neuroscience, 525 East 68th Street, New York, NY 10065, USA
    Neurosci Lett 492:150-4. 2011
    ..Also, the reduction of NOX-mediated oxidative stress may not be sufficient to prevent AD, since other sources of reactive oxygen species such as mitochondria may be more important...
  34. ncbi Evidence against a role for NADPH oxidase modulating hepatic vascular tone in cirrhosis
    Jorge Gracia-Sancho
    Hepatic Hemodynamic Laboratory, Liver Unit, IMDiM, Hospital Clinic, Ciberehd and Institut d Investigacions Biomèdiques August Pi i Sunyer, University of Barcelona, Spain
    Gastroenterology 133:959-66. 2007
    ..Thus, our aims were to study the molecular and biochemical state of NADPH-oxidase in cirrhotic livers and to investigate its possible role in modulating hepatic vascular tone in cirrhosis...
  35. ncbi Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats
    Irina Tsoy Nizamutdinova
    Department of Pharmacology, School of Medicine, Institute of Health Sciences, Gyeongsang National University, Jinju, Korea
    Planta Med 74:14-8. 2008
    ..The results show that both PF and PN reduced myocardial damage in rat through protection from apoptosis, suggesting that Paeonia albiflora Pallas might be useful in treating myocardial infarction...
  36. ncbi Effect of sildenafil citrate and a nitric oxide donating sildenafil derivative, NCX 911, on cavernosal relaxation and superoxide formation in hypercholesterolaemic rabbits
    Nilima Shukla
    Bristol Heart Institute, Department of Cardiac Surgery, Bristol Royal Infirmary, Bristol BS2 8HW, UK
    Eur J Pharmacol 517:224-31. 2005
    ..It also indicates that NO donating sildenafil may be therapeutically more beneficial than conventional sildenafil in treating erectile dysfunction with an oxidative stress-related aetiology...
  37. ncbi Influence of co-administered danshensu on pharmacokinetic fate and tissue distribution of paeonol in rats
    Hua Li
    Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi an, People s Republic of China
    Planta Med 78:135-40. 2012
    ....
  38. ncbi Aggregation inhibitory activity of minor acetophenones from Paeonia species
    H C Lin
    School of Pharmacy, National Defense Medical Center, Taipei, Taiwan
    Planta Med 65:595-9. 1999
    Two minor acetophenones, 2,5-dihydroxy-4-methoxy-acetophenone (2) and 2,5-dihydroxy-4-methylacetophenone (7) from Paeonia species were found to selectively inhibit the aggregation of rabbit platelets induced by arachidonic acid...
  39. ncbi Caspase-3-dependent proteolytic cleavage of protein kinase Cdelta is essential for oxidative stress-mediated dopaminergic cell death after exposure to methylcyclopentadienyl manganese tricarbonyl
    Vellareddy Anantharam
    Parkinson Disorders Research Program, Department of Biomedical Sciences, Iowa Sate University, Ames, Iowa 50011, USA
    J Neurosci 22:1738-51. 2002
    ..For the first time, these data demonstrate that caspase-3-dependent proteolytic activation of PKCdelta plays a key role in oxidative stress-mediated apoptosis in dopaminergic cells after exposure to an environmental neurotoxic agent...
  40. ncbi Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation
    Daniela Impellizzeri
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Via C Valeria Gazzi, 98100 Messina, Italy
    Biochem Pharmacol 81:636-48. 2011
    ..Thus, based on these findings we propose that NADPH oxidase inhibitor such as apocynin may be useful in the treatment of various inflammatory diseases...
  41. pmc Protein kinase Ctheta is a specific target for inhibition of the HIV type 1 replication in CD4+ T lymphocytes
    María Rosa López-Huertas
    AIDS Immunopathology Unit, National Center of Microbiology, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain
    J Biol Chem 286:27363-77. 2011
    ....
  42. ncbi Inhibition of protein kinase Cdelta reduces tristetraprolin expression by destabilizing its mRNA in activated macrophages
    Tiina Leppänen
    The Immunopharmacology Research Group, University of Tampere Medical School and Research Unit, Tampere University Hospital, Tampere, Finland
    Eur J Pharmacol 628:220-5. 2010
    ..The results suggest that PKCdelta up-regulates the expression of TTP by stabilizing its mRNA which may serve as a feed-back loop to regulate the inflammatory response...
  43. pmc Chronic apocynin treatment attenuates beta amyloid plaque size and microglial number in hAPP(751)(SL) mice
    Melinda E Lull
    Department of Anatomy and Neurobiology, Virginia Commonwealth University Medical Campus, Richmond, Virginia, United States of America
    PLoS ONE 6:e20153. 2011
    ....
  44. ncbi Apocynin attenuates tubular apoptosis and tubulointerstitial fibrosis in transgenic mice independent of hypertension
    Fang Liu
    Department of Medicine, Universite de Montreal, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Research Centre, Montreal, Quebec, Canada
    Kidney Int 75:156-66. 2009
    ....
  45. pmc Inhibition of NAD(P)H oxidase activity blocks vascular endothelial growth factor overexpression and neovascularization during ischemic retinopathy
    Mohamed Al-Shabrawey
    Vascular Biology Center, Medical College of Georgia, 1120 15th St, Augusta, GA 30912 2500, USA
    Am J Pathol 167:599-607. 2005
    ..In conclusion, NAD(P)H oxidase activity is required for hypoxia-stimulated increases in VEGF expression and retinal neovascularization. Inhibition of NAD(P)H oxidase offers a new therapeutic target for the treatment of retinopathy...
  46. ncbi Apocynin decreases hydrogen peroxide and nitrate concentrations in exhaled breath in healthy subjects
    J Stefanska
    Department of Immunopathology, Medical University of Lodz, 251 Pomorska Street, Building C5, 92 213 Lodz, Poland
    Pulm Pharmacol Ther 23:48-54. 2010
    ..Thus, as apocynin significantly influence ROS concentration, it might have also antiinflammatory properties. As it is safe, it may have a potential to become a drug in airway inflammatory diseases treatment...
  47. ncbi Apocynin-induced vasodilation involves Rho kinase inhibition but not NADPH oxidase inhibition
    Torsten Schlüter
    Department of Physiology, University of Greifswald, Greifswalder Street 11C, D17495 Greifswald, Karlsburg, Germany
    Cardiovasc Res 80:271-9. 2008
    ..Further experiments were performed in normotensive rats and in NADPH oxidase subunit knock-out mice to test if apocynin-induced vasodilation depends on NADPH oxidase inhibition at all...
  48. ncbi Protein kinase C-delta is commonly expressed in multiple myeloma cells and its downregulation by rottlerin causes apoptosis
    Hongyu Ni
    Department of Pathology, Loyola University Medical Center, EMS Building, 2160 S First Avenue, Maywood, IL 60153, USA
    Br J Haematol 121:849-56. 2003
    ..Our results indicate that PKC-delta is commonly expressed in myeloma cells and plays an important role in plasma cell survival...
  49. ncbi Apocynin attenuate spatial learning deficits and oxidative responses to intermittent hypoxia
    Liu Hui-guo
    Department of Respiratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Key Laboratory of Respiratory Disease, Ministry of Health, Wuhan 430030, China
    Sleep Med 11:205-12. 2010
    ....
  50. pmc NADPH oxidase inhibition improves neurological outcomes in surgically-induced brain injury
    Wendy Lo
    Department of Physiology, Loma Linda University and Loma Linda University School of Medicine, Loma Linda, CA 92350, USA
    Neurosci Lett 414:228-32. 2007
    ..These results suggest that chronic and acute inhibition of NADPH oxidase activity does not reduce brain edema after SBI. Long-term inhibition of NADPH oxidase, however improves neurological functions after SBI...
  51. ncbi NAD(P)H oxidase inhibition improves endothelial function in rat and human blood vessels
    Carlene A Hamilton
    BHF Blood Pressure Group, Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland
    Hypertension 40:755-62. 2002
    ..The increases in NO bioavailability shown here suggest that the NAD(P)H oxidase pathway may be a novel target for drug intervention in cardiovascular disease...
  52. pmc Inhibition of NAD(P)H oxidase reduces apoptosis and avascular retina in an animal model of retinopathy of prematurity
    Yuta Saito
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 13:840-53. 2007
    ....
  53. ncbi Role of xanthine oxidoreductase in the reversal of diastolic heart failure by candesartan in the salt-sensitive hypertensive rat
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto 860 8556, Japan
    Hypertension 50:657-62. 2007
    ..In conclusion, candesartan slowed the exacerbation of hypertensive diastolic heart failure in DS rats by causing reverse cardiac remodeling. Cardiac xanthine oxidoreductase contributed to these beneficial effects of candesartan...
  54. ncbi Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells
    Martin Vejrazka
    Institute of Medical Biochemistry, 1st Faculty of Medicine, Charles University, Katerinska 32, 121 08 Prague 2, Czech Republic
    Biochim Biophys Acta 1722:143-7. 2005
    ..It acts as an inhibitor of phagocyte NADPH oxidase but also as a ROS production stimulator in non-phagocyte cells...
  55. ncbi The oxidation of apocynin catalyzed by myeloperoxidase: proposal for NADPH oxidase inhibition
    Valdecir F Ximenes
    Departamento de Quimica, Faculdade de Ciencias, Universidade Estadual Paulista, Bauru, SP, Brazil
    Arch Biochem Biophys 457:134-41. 2007
    ..We suggest that the reactivity of apocynin radical with thiol compounds could be involved in the inhibitory effect of this methoxy-catechol on NADPH oxidase complex...
  56. ncbi Proteomic analysis of Agrobacterium tumefaciens response to the Vir gene inducer acetosyringone
    Erh Min Lai
    Institute of Plant and Microbial Biology, Academia Sinica, Taipei, Taiwan
    Proteomics 6:4130-6. 2006
    ..This report presents the first proteomics study successfully identifying both known and new AS-induced proteins that are implicated in Agrobacterium virulence...
  57. pmc Selective inhibition by rottlerin of macropinocytosis in monocyte-derived dendritic cells
    Kakali Sarkar
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Immunology 116:513-24. 2005
    ..We conclude that rottlerin is a useful tool for investigating FPE and its functional importance...
  58. ncbi Altered protein kinase C (PKC) isoforms in non-small cell lung cancer cells: PKCdelta promotes cellular survival and chemotherapeutic resistance
    Amy S Clark
    Cancer Therapeutics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20889, USA
    Cancer Res 63:780-6. 2003
    ..Our studies provide a rationale for targeting PKC isoforms in NSCLC cells, especially PKCdelta...
  59. ncbi Rottlerin, a PKC isozyme-selective inhibitor, affects signaling events and cytokine production in human monocytes
    E Kontny
    Department of Pathophysiology and Immunology, Institute of Rheumatology, Warsaw, Poland
    J Leukoc Biol 67:249-58. 2000
    ..Thus, we propose that cytosol-to-membrane translocation of PKCalpha and PKdelta isoenzymes may represent early steps in the signaling cascades that lead to TNF-alpha and IL-1beta production in human monocytes...
  60. pmc Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts
    S A Jimenez
    Division of Rheumatology, Department of Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania 19107 5541, USA
    J Clin Invest 108:1395-403. 2001
    ..The results indicate that PKC-delta participates in the upregulation of collagen gene transcription in SSc and suggest that treatment with PKC-delta inhibitors could suppress fibrosis in this disease...
  61. pmc NADPH oxidase mediates striatal neuronal injury after transient global cerebral ischemia
    Hideyuki Yoshioka
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305 5487, USA
    J Cereb Blood Flow Metab 31:868-80. 2011
    ..These findings suggest that NOX has pivotal roles in MSN injury after tGCI and could be a therapeutic target for brain ischemia...
  62. ncbi Rottlerin synergistically enhances imatinib-induced apoptosis of BCR/ABL-expressing cells through its mitochondrial uncoupling effect independent of protein kinase C-delta
    T Kurosu
    Department of Hematology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Oncogene 26:2975-87. 2007
    ....
  63. ncbi Interpreting steep dose-response curves in early inhibitor discovery
    Brian K Shoichet
    Department of Pharmaceutical Chemistry, University of California San Francisco, 1700 4th Street, San Francisco, California 94158, USA
    J Med Chem 49:7274-7. 2006
    ..Most steep dose-response curves in screening may be due to this effect...
  64. ncbi Activation and induction of cytosolic phospholipase A2 by TNF-α mediated through Nox2, MAPKs, NF-κB, and p300 in human tracheal smooth muscle cells
    Chiang Wen Lee
    Department of Nursing, Division of Basic Medical Sciences, Chronic Diseases and Health Promotion Research Center, Chang Gung Institute of Technology, Chia Yi, Taiwan
    J Cell Physiol 226:2103-14. 2011
    ..These results suggested that in HTSMCs, activation of p47(phox) , MAPKs, NF-κB, and p300 is essential for TNF-α-induced cPLA(2) expression and PGE(2) release...
  65. ncbi Effect of apocynin on ozone-induced airway hyperresponsiveness to methacholine in asthmatics
    E A Peters
    Department of Pulmonology, Leiden University Medical Center, The, Leiden, Netherlands
    Free Radic Biol Med 31:1442-7. 2001
    ..025). We conclude that apocynin markedly reduced O(3)-induced hyperreactivity for Mch as well as maximal airway narrowing. The results suggest that apocynin may have a role in preventing ozone-induced exacerbations of asthma...
  66. pmc Hypercholesterolemia-induced erectile dysfunction: endothelial nitric oxide synthase (eNOS) uncoupling in the mouse penis by NAD(P)H oxidase
    Biljana Musicki
    Department of Urology, Johns Hopkins University, Baltimore, MD 21287, USA
    J Sex Med 7:3023-32. 2010
    ....
  67. ncbi Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells
    Zhang Chunhu
    Research Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China
    Anticancer Drugs 19:401-9. 2008
    ..In addition, paeonol induced DNA fragmentation in the HCC cell line BEL-7404. These observations suggest that paeonol has the potential to be explored for use as an effective antitumor agent for HCC...
  68. pmc Role of NAD(P)H oxidase in superoxide generation and endothelial dysfunction in Goto-Kakizaki (GK) rats as a model of nonobese NIDDM
    Sachin Gupte
    Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, Alabama, United States of America
    PLoS ONE 5:e11800. 2010
    ..This impairment is likely the result of decreased bioavailability of nitric oxide (NO) within the vasculature. However, it is unclear whether hyperglycemia per se stimulates NADPH oxidase-derived superoxide generation in vascular tissue...
  69. ncbi Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones
    Anthony B Pinkerton
    Merck Research Laboratories, MRLSDB2, 3535 General Atomics Court, San Diego, CA 92121, USA
    Bioorg Med Chem Lett 14:5329-32. 2004
    We have identified and synthesized a series of aryl-tetrazoyl acetophenones as positive allosteric potentiators of the metabotropic glutamate receptor 2...
  70. ncbi Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells
    Jun Hee Lim
    Department of Immunology and Chronic Disease Research Center and Institute for Medical Science, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu 700 712, South Korea
    Carcinogenesis 30:729-36. 2009
    ..Thus, DR5-mediated apoptosis, which is induced by rottlerin alone or by the combined treatment with rottlerin and TRAIL, may offer a new therapeutic strategy against cancer...
  71. ncbi NADPH oxidase-mediated oxidative damage to proteins in the postsynaptic density after transient cerebral ischemia and reperfusion
    Kazutoshi Murotomi
    Department of Molecular and Cellular Pharmacology, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Mol Cell Neurosci 46:681-8. 2011
    ....
  72. ncbi Ketamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase
    M Margarita Behrens
    Department of Medicine, Division of Geriatric Medicine, University of California San Diego, La Jolla, CA 92093 0746, USA
    Science 318:1645-7. 2007
    ..These results suggest that NADPH oxidase may represent a novel target for the treatment of ketamine-induced psychosis...
  73. ncbi PKCdelta protects human breast tumor MCF-7 cells against tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis
    Jindan Zhang
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China
    J Cell Biochem 96:522-32. 2005
    ..These findings indicate that PKCdelta functions as a survival factor protecting MCF-7 cells from the apoptosis induced by rsTRAIL...
  74. ncbi Paeonol reduced cerebral infarction involving the superoxide anion and microglia activation in ischemia-reperfusion injured rats
    Ching Liang Hsieh
    Department of Chinese Medicine, China Medical University Hospital, Taichung City, Taiwan
    J Ethnopharmacol 106:208-15. 2006
    ..Paeonol suppresses and scavenges superoxide anion, and inhibit microglia activation and IL-1beta in ischemia-reperfusion injured rats...
  75. ncbi Inhibition of NADPH oxidase prevents advanced glycation end product-mediated damage in diabetic nephropathy through a protein kinase C-alpha-dependent pathway
    Vicki Thallas-Bonke
    JDRF Albert Einstein Centre for Diabetes Complications, Diabetes and Metabolism Division, Baker Medical Research Institute, P O Box 6492, St Kilda Rd, Central, Melbourne, Victoria, Australia
    Diabetes 57:460-9. 2008
    ..Since NADPH oxidase activation is closely linked to other putative pathways, its interaction with changes in protein kinase C (PKC) and increased advanced glycation was examined...
  76. ncbi Rottlerin: an inappropriate and ineffective inhibitor of PKCdelta
    Stephen P Soltoff
    Division of Signal Transduction, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, New Research Building, Room 1030 J, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Trends Pharmacol Sci 28:453-8. 2007
    ....
  77. ncbi Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines
    G P Sun
    Department of Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    Dis Esophagus 21:723-9. 2008
    ..The results show that Pae shows growth inhibitory and apoptosis induction property and may be a promising agent for the EC treatment...
  78. ncbi Fas activation opposes PMA-stimulated changes in the localization of PKCdelta: a mechanism for reducing neutrophil adhesion to endothelial cells
    Bill Hendey
    Department of Pharmacology, Rush University, 2242 W Harrison, Room 264, Chicago, IL 60612, USA
    J Leukoc Biol 71:863-70. 2002
    ..There was no additive effect of Fas activation and rottlerin on reducing adhesion, suggesting that both agents were using a common pathway...
  79. ncbi Apocynin attenuates cerebral infarction after transient focal ischaemia in rats
    L L Tang
    Department of Infectious Disease, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, The People s Republic of China
    J Int Med Res 35:517-22. 2007
    ..These results indicate that inhibition of NADPH oxidase attenuates cerebral infarction after transient focal ischaemia in rats, suggesting that inhibition of NADPH oxidase may provide a therapeutic strategy for ischaemic stroke...
  80. ncbi The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress
    Chiara Riganti
    Dipartimento di Genetica, Biologia e Biochimica, Universita di Torino, Via Santena 5 bis, 10126 Torino, Italy
    Toxicol Appl Pharmacol 228:277-85. 2008
    ....
  81. ncbi Protein kinase C delta regulates anti-apoptotic alphaB-crystallin in the retina of type 2 diabetes
    Y H Kim
    Department of Anatomy and Neurobiology, School of Medicine, Institute of Health Science, Gyeongsang National University, Jinju, Chilam dong 92, Jinju, Gyeongnam 660 751, South Korea
    Neurobiol Dis 28:293-303. 2007
    ..These changes were abolished by rottlerin treatment, a highly specific PKC delta inhibitor. These results suggest that PKC delta is involved in regulation of anti-apoptotic function of alphaBC in the retina of type 2 diabetes...
  82. ncbi Functional role of NADPH oxidase in activation of platelets
    Stefan Chlopicki
    Department of Experimental Pharmacology, Jagiellonian University Medical College, Krakow, Poland
    Antioxid Redox Signal 6:691-8. 2004
    ....
  83. ncbi Reactive oxygen species in rostral ventrolateral medulla modulate cardiac sympathetic afferent reflex in rats
    M K Zhong
    Department of Physiology, Nanjing Medical University, China
    Acta Physiol (Oxf) 197:297-304. 2009
    ....
  84. ncbi Production of (R)-1-phenylethanols through bioreduction of acetophenones by a new fungus isolate Trichothecium roseum
    Kani Zilbeyaz
    Faculty of Sciences, Department of Chemistry, Ataturk University, Erzurum 25240, Turkey
    Chirality 22:543-7. 2010
    A total of 120 fungal strains were isolated from soil samples and evaluated in the bioreduction of substituted acetophenones to the corresponding (R)-alcohols...
  85. ncbi PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells
    Bulent Ozpolat
    Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Autophagy 3:480-3. 2007
    ..In conclusion, our data suggest a novel role of PKC delta/TG2 in regulation of autophagy, and that TG2 may serve as an excellent therapeutic target in pancreatic cancer cells...
  86. ncbi Kalopanaxsaponin A inhibits PMA-induced invasion by reducing matrix metalloproteinase-9 via PI3K/Akt- and PKCdelta-mediated signaling in MCF-7 human breast cancer cells
    Sun Kyu Park
    Department of Applied Life Science, The Graduate School, Yonsei University, Seoul, Korea
    Carcinogenesis 30:1225-33. 2009
    ..Therefore, KPS-A may be a promising anti-invasive agent with the advantage of oral dosing...
  87. ncbi The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes
    Yu ling Ma
    Department of Pharmacology, United Medical and Dental Schools, St Thomas Hospital, Lambeth Palace Road, London SE1 7EH, UK
    Eur J Pharmacol 545:87-92. 2006
    ..These findings suggest that paeonol, and therefore Mudanpi, may possess antiarrhythmic activity, which may confer its cardioprotective effects...
  88. ncbi NF-kappa B activation in tumor necrosis factor alpha-stimulated neutrophils is mediated by protein kinase Cdelta. Correlation to nuclear Ikappa Balpha
    I Vancurova
    Division of Neonatal Perinatal Medicine, Schneider Children s Hospital, Long Island Jewish Medical Center The Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA
    J Biol Chem 276:19746-52. 2001
    ....
  89. ncbi Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils
    E van den Worm
    Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmacy, Utrecht University, PO Box 80082, 3508 TB, Utrecht, The Netherlands
    Eur J Pharmacol 433:225-30. 2001
    ..Our approach may lead to the development of more effective anti-inflammatory agents which are safe and which lack the side effects of steroids...
  90. ncbi Chromobacterium violaceum ω-transaminase variant Trp60Cys shows increased specificity for (S)-1-phenylethylamine and 4'-substituted acetophenones, and follows Swain-Lupton parameterisation
    Karim Engelmark Cassimjee
    KTH Royal Institute of Technology, Division of Biochemistry, School of Biotechnology, AlbaNova University Centre, SE 106 91 Stockholm, Sweden
    Org Biomol Chem 10:5466-70. 2012
    ..The variant Trp60Cys gave increased specificity for (S)-1-phenylethylamine (29-fold) and 4'-substituted acetophenones (∼5-fold). To further study the effect of the mutation the reaction rates were Swain-Lupton parameterised...
  91. ncbi Protective effects of apocynin on "two-hit" injury induced by hemorrhagic shock and lipopolysaccharide
    Rong Zhou
    The Second Department of Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China
    Acta Pharmacol Sin 23:1023-8. 2002
    ..To evaluate the protective effects of apocynin on "two-hit" injury in rats...
  92. ncbi Acetophenones with selective antimycobacterial activity
    L Rajabi
    Department of Biological Sciences and Border Biomedical Research Center, The University of Texas at El Paso, El Paso, TX 79968, USA
    Lett Appl Microbiol 40:212-7. 2005
    ..In this study, the antimycobacterial activity of a small library of acetophenone (AP) compounds was analysed...
  93. ncbi Rottlerin, a specific inhibitor of protein kinase C-delta, impedes barrier repair response by increasing intracellular free calcium
    Bong K Ahn
    Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea
    J Invest Dermatol 126:1348-55. 2006
    ..Furthermore, PKCdelta is important in controlling a decrease in intracellular calcium concentration...
  94. ncbi Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats
    Stefania Schiavone
    Department of Human Physiology and Pharmacology, Vittorio Erspamer, University of Rome, La Sapienza, Italy
    Biol Psychiatry 66:384-92. 2009
    ..Loss of parvalbumin in interneurons is an important feature of these diseases. We studied the role of the superoxide-producing nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase 2 (NOX2) in rats exposed to social isolation...
  95. ncbi Long-term effects of intrauterine malnutrition on vascular function in female offspring: implications of oxidative stress
    Maria C P Franco
    Laboratory of Hypertension, Diabetes and Inflammation, Department of Pharmacology, Institute of Biomedical Sciences Av Prof Lineu Prestes, University of Sao Paulo, Sao Paulo, SP, Brazil
    Life Sci 80:709-15. 2007
    ..These effects may be mediated via modulation of enzyme systems that generate superoxide...
  96. ncbi Transfer hydrogenation in water: enantioselective, catalytic reduction of alpha-cyano and alpha-nitro substituted acetophenones
    Omid Soltani
    Laboratorium fur Organische Chemie, ETH Zurich, Honggerberg, Switzerland
    Org Lett 12:2893-5. 2010
    Catalytic reduction of alpha-substituted acetophenones under conditions involving asymmetric transfer hydrogenation in water is described. The reaction is conducted in water and open to air, and formic acid is used as reductant.
  97. ncbi Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines
    Shu Ping Xu
    Institute of Clinical Pharmacology, Anhui Medical University, Key Laboratory of Anti inflammatory and Immunological Pharmacology, Key Laboratory of Research and Development of Chinese Medicine, Hefei 230032, China
    Acta Pharmacol Sin 28:869-78. 2007
    ..To investigate whether paeonol (Pae) has synergistic effects with cisplatin (CDDP) on the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 and SMMC-7721...
  98. ncbi Rottlerin induces pro-apoptotic endoplasmic reticulum stress through the protein kinase C-delta-independent pathway in human colon cancer cells
    Jun Hee Lim
    Department of Immunology, Chronic Disease Research Center, Institute for Medical Science, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu 700 712, South Korea
    Apoptosis 13:1378-85. 2008
    ..Taken together, the present study thus provides strong evidence to support an important role of ER stress response in mediating the rottlerin-induced apoptosis...
  99. ncbi Rottlerin inhibits stimulated enzymatic secretion and several intracellular signaling transduction pathways in pancreatic acinar cells by a non-PKC-delta-dependent mechanism
    J A Tapia
    Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Biochim Biophys Acta 1763:25-38. 2006
    ..Our results give reasons for a more careful choice of rottlerin for PKC-delta investigation...
  100. ncbi Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation
    S P Soltoff
    Division of Signal Transduction, Harvard Institutes of Medicine, Boston, Massachusetts 02215, USA
    J Biol Chem 276:37986-92. 2001
    ..These results demonstrate that rottlerin directly uncouples mitochondrial respiration from oxidative phosphorylation. Previous studies using rottlerin should be evaluated cautiously...
  101. pmc Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family
    Izumi Ohno
    Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Am J Physiol Gastrointest Liver Physiol 298:G63-73. 2010
    ..Thus rottlerin represents a promising novel agent for pancreatic cancer treatment...

Research Grants35

  1. Tumor Necrosis Factor-Alpha Signaling in Breast Cancer
    Alakananda Basu; Fiscal Year: 2009
    ..The long-term objective is to develop strategies to intervene with these pathways to inhibit progression of breast cancer. ..
  2. SIGNAL TRANSDUCTION AND CELL DEATH REGULATION
    Alakananda Basu; Fiscal Year: 2004
    ....
  3. eNOS-Protein Interaction in the Penis
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time, it may suggest a specific eNOS regulatory pathway as a possible new molecular target for treating ED. [unreadable] [unreadable] [unreadable]..
  4. Posttranslational Regulation of eNOS by Estrogen in the Vagina and Clitoris
    Biljana Musicki; Fiscal Year: 2007
    ..At the same time it may advance treatments for multiple disease states associated with endothelial dysfunction and alterations in hormonal milieu. [unreadable] [unreadable] [unreadable]..
  5. SYNTHESIS OF MDR REVERSING POLYENES
    MERRITT ANDRUS; Fiscal Year: 2003
    ..This is an important first step toward a molecular understanding of the unique recognition properties, transport mechanism of Pgp, and will further facilitate the design of new, more potent reversal agents. ..
  6. MECHANOSENSITIVE MODULATION OF AIRWAY CONTRACTION
    Chi Ming Hai; Fiscal Year: 2008
    ..Understanding the basic science of this cellular mechanism may lead to new methods for the treatment of airway diseases such as asthma. ..
  7. CDI Molecules & NKT Cells in Host Defense
    RANDY BRUTKIEWICZ; Fiscal Year: 2009
    ..abstract_text> ..
  8. Membrane protein electrophoresis in lipid bilayers
    Mary Wirth; Fiscal Year: 2006
    ..If feasible, an R01 proposal would address separations of real mixtures of membrane proteins from cell lysates. The work could have enormous impact on drug discovery, allowing inexpensive screening that encompasses many receptors. ..
  9. Promiscuous and Specific Inhibitors of Cruzain
    Brian Shoichet; Fiscal Year: 2007
    ..We test a rapid method to detect these artifacts, which should significantly advance this critical technique. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  10. Cerebrovascular Disease in Type 1 Diabetes
    WILLIAM MAYHAN; Fiscal Year: 2007
    ..We suggest that our results will provide novel insights regarding therapeutic approaches for the treatment/prevention of cerebrovascular dysfunction in diabetes. ..
  11. The function of RhoBTB proteins
    STEPHEN PAUL SOLTOFF; Fiscal Year: 2010
    ..The results of these studies may reveal a new pathway involved in the development of cancer and advance our understanding of the basic biology of transformation. ..
  12. Ion channel regulation by macromolecular complexes
    Steven O Marx; Fiscal Year: 2010
    ..Since heart failure and hypertrophy are associated with alterations in PKC activity and Ca2+ homeostasis, understanding the PKC modulation of Cav1.2 may contribute to the development of novel therapeutic agents to treat these disorders. ..
  13. PMN integrins, apoptosis and inflammation
    WILLIAM HENDEY; Fiscal Year: 2007
    ..An understanding of this pathway would provide novel targets for the control of inflammation. ..
  14. Antigen-Presenting Function of CD1 Molecules
    RANDY BRUTKIEWICZ; Fiscal Year: 2004
    ..The proposed studies will also have wide-ranging applications in the development of novel treatments aimed not only at CD1 hematopoietic tumor cells, but also infectious diseases and autoimmunity. ..
  15. Mechanisms of Chemoprevention by Resveratrol
    Rakesh Srivastava; Fiscal Year: 2009
    ..Thus, resveratrol based strategies can be utilized for prevention and treatment of prostate cancer, and in the long-term it may have profound impact on the overall incidence of human prostate cancer. ..
  16. DEXAMETHASONE FUNCTION IN BRONCHOPULMONARY DYSPLASIA
    Ivana Vancurova; Fiscal Year: 2002
    ..The development of such therapies will be achieved by a better understanding of the molecular mechanisms underlying the anti-inflammatory action of glucocorticoids in neutrophils. ..
  17. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  18. CHEMICAL INDUCED NEPHROTOXICITY--SUCCINIMIDES
    GARY RANKIN; Fiscal Year: 2001
    ..Collectively, the results of these studies should add important, new knowledge about the nephrotoxic and urotoxic species of succinimides, cellular targets of the toxicant species and potential mechanisms of nephrotoxicity. ..
  19. Involvement of mGluR5 in inhibitory avoidance and aging
    Agnes Simonyi; Fiscal Year: 2004
    ..This information may also be useful for therapeutic research investigating the potential use of mGluR ligands in age-related neurodegenerative disorders, such as Alzheimer's disease. ..
  20. Cerebral Microcirculation During Alcohol Consumption
    WILLIAM MAYHAN; Fiscal Year: 2008
    ..These studies will provide valuable new insights and will lead to new therapeutic approaches for the treatment of cerebrovascular abnormalities observed in chronic alcoholics. [unreadable] [unreadable]..
  21. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  22. TRANSGENIC/KNOCKOUT ANIMALS IN MYOCARDIAL PRESERVATION
    DIPAK DAS; Fiscal Year: 2008
    ..The results of this proposed research will hopefully increase our understanding of redox regulation by Trx/Grx in the ischemic myocardium. [unreadable] [unreadable]..
  23. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..In addition, results of these studies may provide insights regarding possible therapeutic approaches for the treatment of nicotine-induced vascular dysfunction. ..
  24. Endothelial Transmigration Across the RPE Barrier
    Mary Elizabeth Hartnett; Fiscal Year: 2005
    ..Increased knowledge of the mechanisms that cause this destructive phenomenon may lead to future means to prevent CNV in the neurosensory retina, and thus, reduce vision loss in AMD. ..
  25. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  26. MAST CELLS IN INNATE IMMUNITY AGAINST BACTERIAL INFECTIO
    Ravi Malaviya; Fiscal Year: 2001
    ..These studies will provide new insights regarding the participation of mast cells in innate host defense against pathogenic gram negative bacteria. ..
  27. PHOSPHOLIPID SIGNALING IN MYOCARDIAL ISCHEMIC INJURY
    DIPAK DAS; Fiscal Year: 2009
    ....
  28. Genetic Analysis of Vascular Aging
    Steven Miller; Fiscal Year: 2003
    ..abstract_text> ..
  29. Identification of a new protein that binds Src and PKC
    STEPHEN SOLTOFF; Fiscal Year: 2004
    ..Future efforts will determine if this new protein alters cell morphology, tight junction formation, or other functions in salivary cells. ..
  30. MYOCARDIAL PRESERVATION DURING ISCHEMIC ARREST
    DIPAK DAS; Fiscal Year: 2009
    ..Ischemic heart disease represent the major cardiovascular related problems. Straitegies to reduce ischemic injury should improve the heart health leading to the reduction of death due to heart diseases. ..
  31. BALANCED BIOACTIVITY OF ALZHEIMER BETA AMYLOID PRECURSOR
    STEVEN BARGER; Fiscal Year: 2004
    ..Specifically, elucidation of the cellular mechanisms through which sAPP activates microglia may provide targets for therapeutic intervention in Alzheimer's disease. ..
  32. Renal NO synthase & blood pressure
    Jeffrey Garvin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. Pancreatic zymogen activation in a reconstituted system
    Edwin Thrower; Fiscal Year: 2006
    ..We plan to use this system to identify the compartment(s) responsible for zymogen processing and to examine the ATP and calcium-dependent mechanism of activation. [unreadable] [unreadable] [unreadable]..
  34. Sp1, kappa-B enhancers and transcriptions in neurons
    STEVEN BARGER; Fiscal Year: 2009
    ..abstract_text> ..