acetone

Summary

Summary: A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.

Top Publications

  1. ncbi Achievements and perspectives to overcome the poor solvent resistance in acetone and butanol-producing microorganisms
    Thaddeus Ezeji
    Department of Animal Sciences and Ohio State Agricultural Research and Development Center OARDC, The Ohio State University, 305 Gerlaugh Hall, 1680 Madison Avenue, Wooster, OH 44691, USA
    Appl Microbiol Biotechnol 85:1697-712. 2010
  2. ncbi Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis
    Yeung Leung Cheng
    School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, ROC
    Life Sci 75:1579-94. 2004
  3. ncbi Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
    Ryan Sillers
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
    Metab Eng 10:321-32. 2008
  4. ncbi Low-temperature growth of ZnO nanoparticles: photocatalyst and acetone sensor
    Sher Bahadar Khan
    Centre for Advanced Materials and Nano Engineering CAMNE, Department of Chemistry, Faculty of Sciences and Arts, Najran University, P O Box 1988, Najran 11001, Saudi Arabia
    Talanta 85:943-9. 2011
  5. ncbi Consistent sets of spectrophotometric chlorophyll equations for acetone, methanol and ethanol solvents
    Raymond J Ritchie
    School of Biological Sciences, The University of Sydney, Sydney, NSW 2006, Australia
    Photosynth Res 89:27-41. 2006
  6. ncbi Production of acetone, butanol, and ethanol from biomass of the green seaweed Ulva lactuca
    Hetty van der Wal
    Food and Biobased Research, Wageningen University and Research Centre, Bornse Weilanden 9, 6708 CT Wageningen, The Netherlands
    Bioresour Technol 128:431-7. 2013
  7. ncbi A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Dornbirn
    J Math Biol 63:959-99. 2011
  8. pmc Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis
    Hanna M Dudek
    Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
    Appl Environ Microbiol 77:5730-8. 2011
  9. ncbi Evaluation of unbound free heme in plant cells by differential acetone extraction
    Nino A Espinas
    Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Plant Cell Physiol 53:1344-54. 2012
  10. ncbi Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations
    Ryan Sillers
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 102:38-49. 2009

Research Grants

Detail Information

Publications359 found, 100 shown here

  1. ncbi Achievements and perspectives to overcome the poor solvent resistance in acetone and butanol-producing microorganisms
    Thaddeus Ezeji
    Department of Animal Sciences and Ohio State Agricultural Research and Development Center OARDC, The Ohio State University, 305 Gerlaugh Hall, 1680 Madison Avenue, Wooster, OH 44691, USA
    Appl Microbiol Biotechnol 85:1697-712. 2010
    ..cellobiose, mannose, xylose, and arabinose) to produce carboxylic acids (acetic and butyric) and solvents such as acetone, butanol, and ethanol (ABE)...
  2. ncbi Acetone extract of Angelica sinensis inhibits proliferation of human cancer cells via inducing cell cycle arrest and apoptosis
    Yeung Leung Cheng
    School of Pharmacy, National Defense Medical Center, Taipei 114, Taiwan, ROC
    Life Sci 75:1579-94. 2004
    ..Bio-based assays for extracts of Angelica sinensis showed that the acetone extract (AE-AS) had dose-dependently antiproliferative effect on A549, HT29, DBTRG-05MG and J5 human cancer cells...
  3. ncbi Metabolic engineering of the non-sporulating, non-solventogenic Clostridium acetobutylicum strain M5 to produce butanol without acetone demonstrate the robustness of the acid-formation pathways and the importance of the electron balance
    Ryan Sillers
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
    Metab Eng 10:321-32. 2008
    ..acetobutylicum M5 strain (which has lost the pSOL1 megaplasmid containing aad and the acetone-formation genes) with aad expressed from the phosphotransbutyrylase promoter and restored butanol production to ..
  4. ncbi Low-temperature growth of ZnO nanoparticles: photocatalyst and acetone sensor
    Sher Bahadar Khan
    Centre for Advanced Materials and Nano Engineering CAMNE, Department of Chemistry, Faculty of Sciences and Arts, Najran University, P O Box 1988, Najran 11001, Saudi Arabia
    Talanta 85:943-9. 2011
    ..for the degradation of acridine orange (AO) and as a chemi-sensor for the electrochemical sensing of acetone in liquid phase. Almost complete degradation of AO has taken place after 80 min of irradiation time...
  5. ncbi Consistent sets of spectrophotometric chlorophyll equations for acetone, methanol and ethanol solvents
    Raymond J Ritchie
    School of Biological Sciences, The University of Sydney, Sydney, NSW 2006, Australia
    Photosynth Res 89:27-41. 2006
    ..marina, which uses Chl d as its primary photosynthetic pigment and also has Chl a, have been developed for 90% acetone, methanol and ethanol solvents...
  6. ncbi Production of acetone, butanol, and ethanol from biomass of the green seaweed Ulva lactuca
    Hetty van der Wal
    Food and Biobased Research, Wageningen University and Research Centre, Bornse Weilanden 9, 6708 CT Wageningen, The Netherlands
    Bioresour Technol 128:431-7. 2013
    ..Ulva lactuca harvested from the North Sea near Zeeland (The Netherlands) was characterized as feedstock for acetone, ethanol and ethanol fermentation...
  7. ncbi A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Dornbirn
    J Math Biol 63:959-99. 2011
    ..The classical Farhi equation takes only the alveolar concentrations into account. Real-time measurements of acetone in end-tidal breath under an ergometer challenge show characteristics which cannot be explained within the Farhi ..
  8. pmc Mapping the substrate binding site of phenylacetone monooxygenase from Thermobifida fusca by mutational analysis
    Hanna M Dudek
    Laboratory of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Groningen, The Netherlands
    Appl Environ Microbiol 77:5730-8. 2011
    ..These findings will aid in more dedicated and effective redesign of PAMO and related monooxygenases toward an expanded substrate scope...
  9. ncbi Evaluation of unbound free heme in plant cells by differential acetone extraction
    Nino A Espinas
    Graduate School of Science, The University of Tokyo, Tokyo, Japan
    Plant Cell Physiol 53:1344-54. 2012
    ..Classically, total non-covalently bound heme is extracted from plant samples with acidic acetone after removal of pigments with basic and neutral acetone...
  10. ncbi Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations
    Ryan Sillers
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA
    Biotechnol Bioeng 102:38-49. 2009
    Metabolic engineering (ME) of Clostridium acetobutylicum has led to increased solvent (butanol, acetone, and ethanol) production and solvent tolerance, thus demonstrating that further efforts have the potential to create strains of ..
  11. ncbi Dynamic profiles of volatile organic compounds in exhaled breath as determined by a coupled PTR-MS/GC-MS study
    J King
    University Clinic for Anesthesia, Innsbruck Medical University, Anichstr 35, A 6020 Innsbruck, Austria
    Physiol Meas 31:1169-84. 2010
    ....
  12. ncbi Acetone, ethanol and methanol extracts of Phyllanthus urinaria inhibit HSV-2 infection in vitro
    Chien Min Yang
    Graduate Institute of Pharmaceutical Sciences, College of Pharmacy, No 100, Shin Chuan 1 st Road, Kaohsiung Medical University, 807 Kaohsiung, Taiwan, ROC
    Antiviral Res 67:24-30. 2005
    ..urinaria were investigated in vitro by plaque reduction assay. Results showed that acetone, ethanol and methanol extracts of P. urinaria inhibited HSV-2 but not HSV-1 infection...
  13. ncbi Field experiments with transformed plants reveal the sense of floral scents
    Danny Kessler
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, Hans Knoll Strasse 8, DE 07745 Jena, Germany
    Science 321:1200-2. 2008
    ..We blocked expression of biosynthetic genes of the dominant floral attractant [benzyl acetone (Nachal1)] and nectar repellent [nicotine (Napmt1/2)] in all combinations in the native tobacco Nicotiana ..
  14. ncbi Responses of the biting midge Culicoides impunctatus to acetone, CO2 and 1-octen-3-ol in a wind tunnel
    A Bhasin
    Department of Zoology, University of Aberdeen, U K
    Med Vet Entomol 14:300-7. 2000
    Responses of host-seeking female Culicoides impunctatus (Goetghebuer) (Diptera: Ceratopogonidae) to acetone, carbon dioxide and 1-octen-3-ol were measured in a wind tunnel...
  15. ncbi Measurement of endogenous acetone and isoprene in exhaled breath during sleep
    Julian King
    Breath Research Institute, Austrian Academy of Sciences, Rathausplatz 4, A 6850 Dornbirn, Austria
    Physiol Meas 33:413-28. 2012
    This explorative study aims at characterizing the breath behavior of two prototypic volatile organic compounds, acetone and isoprene, during normal human sleep and to possibly relate changes in the respective concentration time courses ..
  16. ncbi Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide
    Jie Zhou
    Institute of Microbiology, Chinese Academy of Sciences, No 1 West Beichen Road, Chaoyang District, Beijing 100101, China
    Metab Eng 14:394-400. 2012
    Ketones are a class of important organic compounds. As the simplest ketone, acetone is widely used as solvents or precursors for industrial chemicals...
  17. ncbi Global transcriptional changes of Clostridium acetobutylicum cultures with increased butanol:acetone ratios
    Daniel Hönicke
    Abteilung Mikrobiologie, Institut für Biowissenschaften, Universitat Rostock, Germany
    N Biotechnol 29:485-93. 2012
    Artificial electron carriers have been widely used to shift the solvent ratio toward butanol in acetone-butanol-ethanol (ABE) fermentation of solventogenic clostridia according to decreased hydrogen production...
  18. ncbi The anticonvulsant activity of acetone, the major ketone body in the ketogenic diet, is not dependent on its metabolites acetol, 1,2-propanediol, methylglyoxal, or pyruvic acid
    Maciej Gasior
    Epilepsy Research Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 3702, USA
    Epilepsia 48:793-800. 2007
    b>Acetone, one of the principal ketone bodies elevated during treatment with the ketogenic diet, exhibits anticonvulsant properties that may contribute to the seizure protection conferred by the diet...
  19. ncbi Acetone production in solventogenic Clostridium species: new insights from non-enzymatic decarboxylation of acetoacetate
    Bei Han
    Department of Animal Sciences and Ohio State Agricultural Research and Development Center, The Ohio State University, 305 Gerlaugh Hall, 1680 Madison Avenue, Wooster, OH 44691, USA
    Appl Microbiol Biotechnol 91:565-76. 2011
    ..aadc) gene encoding acetoacetate decarboxylase (AADC), which catalyzes the decarboxylation of acetoacetate into acetone and CO(2), was successfully disrupted by homologous recombination in solventogenic Clostridium beijerinckii NCIMB ..
  20. ncbi Monoclonal antibody production to human and bovine 2':3'-cyclic nucleotide 3'-phosphodiesterase (CNPase): high-specificity recognition in whole brain acetone powders and conservation of sequence between CNP1 and CNP2
    T J Sprinkle
    Research Service, Pathology, VA Medical Center, Augusta, GA 30910
    Brain Res 426:349-57. 1987
    ..corresponding to those immunostained in central nervous system (CNS) myelin, the Wolfgram protein fraction and in acetone powders of whole brain...
  21. ncbi Distribution and differential induction of CYP2E1 by ethanol and acetone in the mesocorticolimbic system of rat
    M José Sánchez-Catalán
    Departamento de Farmacia y Tecnologia Farmaceutica, Universidad de Valencia, Avda Vicente Andres Estelles s n, 46100, Burjassot, Spain
    Alcohol Alcohol 43:401-7. 2008
    ..Hence, we have performed a detailed study of the CYP2E1 expression and induction in three key areas of the mesocorticolimbic system of the rat brain: prefrontal cortex (PFC), nucleus accumbens (NAc), and ventral tegmental area (VTA)...
  22. ncbi Secondary alcohol dehydrogenase catalyzes the reduction of exogenous acetone to 2-propanol in Trichomonas vaginalis
    Robert Sutak
    Department of Parasitology, Faculty of Science, Charles University in Prague, Vinicna 7, Prague, Czech Republic
    FEBS J 279:2768-80. 2012
    ..However, S-ADH provided the parasite with a high capacity to scavenge and reduce external acetone to 2-propanol...
  23. ncbi Inhibition of fowlpox virus by an aqueous acetone extract from galls of Guiera senegalensis J. F. Gmel (Combretaceae)
    Charles E Lamien
    Laboratoire de Biochimie et Chimie Appliquées, UFR SVT, Universite de Ouagadougou, BP 7021, Ouagadougou 03, Burkina Faso
    J Ethnopharmacol 96:249-53. 2005
    An aqueous acetone extract from the galls of Guiera senegalensis was screened for in vitro antiviral activity against fowlpox virus (FPV)...
  24. pmc A systems biology approach to investigate the effect of pH-induced gene regulation on solvent production by Clostridium acetobutylicum in continuous culture
    Sylvia Haus
    University of Rostock, Institute of Computer Science, Department of Systems Biology and Bioinformatics, 18051 Rostock, Germany
    BMC Syst Biol 5:10. 2011
    ..an anaerobic bacterium which is known for its solvent-producing capabilities, namely regarding the bulk chemicals acetone and butanol, the latter being a highly efficient biofuel. For butanol production by C...
  25. ncbi Larvicidal and chemosterilant activity of the acetone fraction of petroleum ether extract from Argemone mexicana L seed
    M Sakthivadivel
    MS Swaminathan Research Foundation, 3rd Cross Street, Taramani Institutional Area, Chennai 600 113, Tamil Nadu, India
    Bioresour Technol 89:213-6. 2003
    The acetone fraction of the petroleum ether extract of seeds from Argemone mexicana L. exhibited larvicidal and growth inhibiting activity against the second instar larvae of Aedes aegypti (Linn)...
  26. pmc Inhibitory and bactericidal potential of crude acetone extracts of Combretum molle (Combretaceae) on drug-resistant strains of Helicobacter pylori
    Collise Njume
    Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, P Bag X1314, Alice 5700, South Africa
    J Health Popul Nutr 29:438-45. 2011
    ..The most potent anti-H. pylori activity was demonstrated by the acetone extract, to which 87.5% of the clinical strains were susceptible...
  27. ncbi Aerobic oxidation of aminoacetone, a threonine catabolite: iron catalysis and coupled iron release from ferritin
    F Dutra
    , , , CP 26077, 05513-970, , SP, Brazil
    Chem Res Toxicol 14:1323-9. 2001
    ..It is noteworthy that noninsulin-dependent diabetes has been frequently associated with iron overload and oxidative stress...
  28. pmc An improved kinetic model for the acetone-butanol-ethanol pathway of Clostridium acetobutylicum and model-based perturbation analysis
    Ru Dong Li
    Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    BMC Syst Biol 5:S12. 2011
    ..Clostridium acetobutylicum produces solvents (acetone-butanol-ethanol, ABE) through the ABE pathway...
  29. ncbi Use of acetone to attain highly active and soluble DNA packaging protein Gp16 of Phi29 for ATPase assay
    Lisa P Huang
    Department of Pathobiology, Purdue University, West Lafayette, IN 47907, USA
    Virology 312:449-57. 2003
    ..to obtain affinity-purified, soluble, and highly active native gp16 with the aid of polyethylene glycol or acetone. The specific activity of this native gp16 was increased 3400-fold when compared with the traditional method...
  30. ncbi Modifying the product pattern of Clostridium acetobutylicum: physiological effects of disrupting the acetate and acetone formation pathways
    Dörte Lehmann
    Abteilung Mikrobiologie, Institut für Biowissenschaften, Universitat Rostock, Albert Einstein Str 3, 18059 Rostock, Germany
    Appl Microbiol Biotechnol 94:743-54. 2012
    Clostridial acetone-butanol-ethanol (ABE) fermentation is a natural source for microbial n-butanol production and regained much interest in academia and industry in the past years...
  31. ncbi Enzymatic degradation of anthracene, dibenzothiophene and pyrene by manganese peroxidase in media containing acetone
    Gemma Eibes
    Department of Chemical Engineering, School of Engineering, University of Santiago de Compostela, E 15782 Santiago de Compostela, Spain
    Chemosphere 64:408-14. 2006
    ..The enzymatic action of the enzyme manganese peroxidase (MnP) in media containing a miscible organic solvent, acetone (36% v/v), was evaluated as a feasible system for the in vitro degradation of three PAHs: anthracene, ..
  32. ncbi Rewetting strategies for bonding to dry dentin with an acetone-based adhesive
    W J Finger
    University of Cologne, Dental School, Department of Preclinical Dentistry, Kerpener Str 32, 50931 Cologne, Germany
    J Adhes Dent 2:51-6. 2000
    ..Excessive drying after rewetting had no compromising effect on adhesion in the HEMA- and GLUMA-primed groups, whereas the water and glutardialdehyde-treated groups showed poor bonding...
  33. ncbi A fluorometric high-performance liquid chromatography procedure for simultaneous determination of methylamine and aminoacetone in blood and tissues
    Shengyuan Xiao
    Department of Pharmacology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N5E4
    Anal Biochem 384:20-6. 2009
    ..Methylamine and aminoacetone distributed unevenly among different tissues ranged from 0.1 to 27 nmol/g. To our knowledge, this is the first report on simultaneous determination of methylamine and aminoacetone in mammal tissues...
  34. ncbi Sequence and arrangement of genes encoding enzymes of the acetone-production pathway of Clostridium acetobutylicum ATCC824
    D J Petersen
    F A Janssens Laboratorium voor Genetica, K V Leuven, Heverlee, Belgium
    Gene 123:93-7. 1993
    The nucleotide sequence of three open reading frames in the acetone-production locus of Clostridium acetobutylicum ATCC824 has been established. The three gene products, corresponding to acetoacetate decarboxylase (EC 4.1.1...
  35. ncbi Highly efficient chemoselective deprotection of O,O-acetals and O,O-ketals catalyzed by molecular iodine in acetone
    Jianwei Sun
    Department of Chemistry, Tsinghua University, Beijing 100084, P R China
    J Org Chem 69:8932-4. 2004
    An extremely convenient method for deprotection of acetals and ketals catalyzed by molecular iodine (10 mol %) in acetone is reported...
  36. ncbi Medicinal properties of fractionated acetone/water neem [Azadirachta indica] leaf extract from Nigeria: a review
    Ugochukwu B Anyaehie
    Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Nigeria
    Niger J Physiol Sci 24:157-9. 2009
    ..This paper reviews the medicinal properties, clinical studies and safety concerns of this fractionated acetone-water neem leaves extract as a footstep to further studies both on the extract and/or its chemical constituents.
  37. ncbi Celecoxib-loaded poly(D,L-lactide-co-glycolide) nanoparticles prepared using a novel and controllable combination of diffusion and emulsification steps as part of the salting-out procedure
    Paul A McCarron
    School of Pharmacy, Queens University Belfast, Medical Biology Centre, Belfast, UK
    J Microencapsul 23:480-98. 2006
    ..1%; salting out, 10.0%). The ratio of a water miscible solvent (acetone) to a non water-miscible solvent (dichloromethane) was shown to be the primary determinants of size and drug ..
  38. pmc Transcriptional analysis of Clostridium beijerinckii NCIMB 8052 and the hyper-butanol-producing mutant BA101 during the shift from acidogenesis to solventogenesis
    Zhen Shi
    Institute for Genomic Biology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Appl Environ Microbiol 74:7709-14. 2008
    Clostridium beijerinckii is an anaerobic bacterium used for the fermentative production of acetone and butanol. The recent availability of genomic sequence information for C...
  39. ncbi Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation
    Visith Thongboonkerd
    Core Proteomics Laboratory and Molecular Signaling Group, Kidney Disease Program, Department of Medicine, University of Louisville, 570 South Preston Street, Louisville, KY 40202, USA
    Kidney Int 62:1461-9. 2002
    ..We constructed a proteome map of normal human urine as a reference protein database by using two differential fractionated techniques to isolate the proteins...
  40. pmc Crystal structure of a Baeyer-Villiger monooxygenase
    Enrico Malito
    Department of Genetics and Microbiology, University of Pavia, Via Ferrata 1, 27100 Pavia, Italy
    Proc Natl Acad Sci U S A 101:13157-62. 2004
    ....
  41. ncbi Evaporation of solvent in one-bottle adhesives
    P F Abate
    Department of Dental Materials, School of Dentistry, University of Buenos Aires, Argentina
    J Dent 28:437-40. 2000
    ..To compare the evaporation of vehicles included in different single-bottle adhesives as a function of time...
  42. ncbi Kinetic modeling and sensitivity analysis of acetone-butanol-ethanol production
    Hideaki Shinto
    Laboratory of Microbial Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka, Japan
    J Biotechnol 131:45-56. 2007
    A kinetic simulation model of metabolic pathways that describes the dynamic behaviors of metabolites in acetone-butanol-ethanol (ABE) production by Clostridium saccharoperbutylacetonicum N1-4 was proposed using a novel simulator WinBEST-..
  43. ncbi Antioxidant activity of acetone extract/fractions of Terminalia bellerica Roxb. fruit
    Sanjay Guleria
    Division of Biochemistry and Plant Physiology, Sher e Kashmir University of Agricultural Sciences and Technology, Chatha 180 009, Jammu, India
    Indian J Biochem Biophys 47:110-6. 2010
    ..In the present study, the free radical scavenging activity and antioxidant potential of acetone extract/fractions of its fruit was investigated using in vitro assays, including scavenging ability against 2,2'-..
  44. pmc New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells
    Cheolho Cheong
    Laboratory of Cellular Physiology and Immunology and Chris Browne Center for Immunology and Immune Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    J Immunol Methods 360:66-75. 2010
    ..Current anti-mouse DC-SIGN monoclonal antibodies (MAbs) are unable to react with DC-SIGN in acetone-fixed cells, limiting the chance to visualize DC-SIGN in tissue sections...
  45. pmc Autophagic cell death is induced by acetone and ethyl acetate extracts from Eupatorium odoratum in vitro: effects on MCF-7 and vero cell lines
    Faizah Bt Harun
    Institute for Research in Molecular Medicine INFORMM, Universiti Sains Malaysia, Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia
    ScientificWorldJournal 2012:439479. 2012
    ..These results thus suggest that acetone and ethyl acetate extracts of EO induce cell death through induction of autophagy and hold potential for ..
  46. pmc Nitrate-dependent degradation of acetone by Alicycliphilus and Paracoccus strains and comparison of acetone carboxylase enzymes
    Carlos Henrique Dullius
    Fachbereich Biologie, University of Constance, D 78457 Constance, Germany
    Appl Environ Microbiol 77:6821-5. 2011
    A novel acetone-degrading, nitrate-reducing bacterium, strain KN Bun08, was isolated from an enrichment culture with butanone and nitrate as the sole sources of carbon and energy. The cells were motile short rods, 0...
  47. pmc Breath acetone monitoring by portable Si:WO3 gas sensors
    Marco Righettoni
    Particle Technology Laboratory, Department of Mechanical and Process Engineering ETH Zurich, CH 8092 Zurich, Switzerland
    Anal Chim Acta 738:69-75. 2012
    ..In particular, the detection of acetone in the human breath is promising for non-invasive diagnosis and painless monitoring of diabetes (no finger ..
  48. ncbi Highly enhanced acetone sensing performances of porous and single crystalline ZnO nanosheets: high percentage of exposed (100) facets working together with surface modification with Pd nanoparticles
    Yuanhua Xiao
    College of Materials and Chemical Engineering, State Laboratory of Surface and Interface Science and Technology, Zhengzhou University of Light Industry, Zhengzhou 450002, P R China
    ACS Appl Mater Interfaces 4:3797-804. 2012
    ..the chemical sensors made with porous ZnO nanosheets exhibit high selectivity and quick response for detecting acetone, because of the 2D ZnO nanocrystals exposed in (100) facets at high percentage...
  49. pmc A proteomic and transcriptional view of acidogenic and solventogenic steady-state cells of Clostridium acetobutylicum in a chemostat culture
    Holger Janssen
    Institut für Biowissenschaften, Universitat Rostock, Germany
    Appl Microbiol Biotechnol 87:2209-26. 2010
    ..to acetate and butyrate, and in the transition phase, the metabolism switches to the production of the solvents acetone and butanol accompanied by the initiation of endospore formation...
  50. ncbi A prototype portable breath acetone analyzer for monitoring fat loss
    Tsuguyoshi Toyooka
    Research Laboratories, NTT DoCoMo, Inc, 3 6 Hikarinooka, Yokosuka, 239 8536, Japan
    J Breath Res 7:036005. 2013
    b>Acetone contained in our exhaled breath is a metabolic product of the breakdown of body fat and is expected to be a good indicator of fat-burning...
  51. ncbi Asymmetric aldol reactions between acetone and benzaldehydes catalyzed by chiral Zn2+ complexes of aminoacyl 1,4,7,10-tetraazacyclododecane: fine-tuning of the amino-acid side chains and a revised reaction mechanism
    Susumu Itoh
    Production Technology Laboratories, Kaken Pharmaceutical Co Ltd 301 Gensuke, Fujieda, Shizuoka 426 8646, Japan
    Chem Asian J 8:2125-35. 2013
    ..designed to mimic the actions of class-I and class-II aldolases catalyzed the enantioselective aldol reactions of acetone and its analogues thereof with benzaldehyde derivatives...
  52. ncbi Neurotropin inhibits the increase in intraepidermal nerve density in the acetone-treated dry-skin mouse model
    A Kamo
    Juntendo University Graduate School of Medicine, Tomioka, Urayasu, Chiba, Japan
    Clin Exp Dermatol 38:665-8. 2013
    ..intraperitoneal administration of NTP on nerve density and expression of NGF and Sema3A mRNAs in the epidermis of acetone-treated mice showing epidermal hyperinnervation...
  53. ncbi Effect of zinc supplementation on acetone-butanol-ethanol fermentation by Clostridium acetobutylicum
    You Duo Wu
    School of Life Sciences and Biotechnology, Dalian University of Technology, Dalian 116024, China
    J Biotechnol 165:18-21. 2013
    In this article, effect of zinc supplementation on acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum was studied. It was found that when 0...
  54. ncbi The VUV electronic spectroscopy of acetone studied by synchrotron radiation
    M Nobre
    Laboratório de Colisões Atómicas e Moleculares, Departamento de Fisica, CEFITEC, Universidade Nova de Lisboa, 2829 516, Caparica, Portugal
    Phys Chem Chem Phys 10:550-60. 2008
    The electronic state spectroscopy of acetone (CH3)2CO has been investigated using high-resolution VUV photoabsorption spectroscopy in the energy range 3.7-10.8 eV...
  55. ncbi Whole body radioprotective activity of an acetone-water extract from the seedpod of Nelumbo nucifera Gaertn. seedpod
    Y Duan
    School of Food and Biological Engineering, Jiangsu University, Zhenjiang, China
    Food Chem Toxicol 48:3374-84. 2010
    Procyanidins extracted with acetone-water from lotus (Nelumbo nucifera Gaertn.) seedpod (LSPCs) were evaluated for in vivo radioprotective activity against whole body gamma irradiation in Swiss albino mice...
  56. ncbi Odorant differentiated pattern of cerebral activation: comparison of acetone and vanillin
    Ivanka Savic
    Division of Human Brain Research, Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Hum Brain Mapp 17:17-27. 2002
    ..separate conditions: birhinal, passive smelling of: 1) the unimodal odorant vanillin; 2) the bimodal odorant acetone; and 3) odorless air...
  57. ncbi Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis
    Arpad Farkas
    Department of Dermatology and Allergology, Faculty of General Medicine, University of Szeged, PO Box 427, H 6701, Szeged, Hungary
    Arch Dermatol Res 295:56-62. 2003
    ..In the present study we examined the effects of ethanol and acetone, which exceeds its normal endogenous level in the blood of heavy drinkers, on the proliferation of HaCaT ..
  58. ncbi Si:WO(3) Sensors for highly selective detection of acetone for easy diagnosis of diabetes by breath analysis
    Marco Righettoni
    Particle Technology Laboratory, Department of Mechanical and Process Engineering, Institute of Process Engineering, ETH Zurich, CH 8092 Zurich, Switzerland
    Anal Chem 82:3581-7. 2010
    b>Acetone in the human breath is an important marker for noninvasive diagnosis of diabetes...
  59. ncbi Photodynamics of the bacteriochlorophyll-carotenoid system. 1. Bacteriochlorophyll-photosensitized oxygenation of beta-carotene in acetone
    J Fiedor
    , Menzinger Str. 67, D-80638 Munich, Germany
    Photochem Photobiol 74:64-71. 2001
    ..g. isomerizations or oxidations. We have found that beta-carotene (Car) in aerobic acetone is rapidly oxygenated under strong illumination with red light (lambda exc > or = 630 nm) in the presence of ..
  60. ncbi Continuous bio-catalytic conversion of sugar mixture to acetone-butanol-ethanol by immobilized Clostridium acetobutylicum DSM 792
    Shrikant A Survase
    Department of Biotechnology and Chemical Technology, Aalto University School of Chemical Engineering, Aalto, Finland
    Appl Microbiol Biotechnol 93:2309-16. 2012
    Continuous production of acetone, n-butanol, and ethanol (ABE) was carried out using immobilized cells of Clostridium acetobutylicum DSM 792 using glucose and sugar mixture as a substrate...
  61. ncbi Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells
    Adriano Sartori
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, SP, Brazil
    Chem Res Toxicol 21:1841-50. 2008
    Aminoacetone (AA), triose phosphates, and acetone are putative endogenous sources of potentially cytotoxic and genotoxic methylglyoxal (MG), which has been reported to be augmented in the plasma of diabetic patients...
  62. pmc Acetone and butanone metabolism of the denitrifying bacterium "Aromatoleum aromaticum" demonstrates novel biochemical properties of an ATP-dependent aliphatic ketone carboxylase
    Karola Schühle
    Laboratory for Microbiology, University of Marburg, Marburg, Germany
    J Bacteriol 194:131-41. 2012
    The anaerobic and aerobic metabolism of acetone and butanone in the betaproteobacterium "Aromatoleum aromaticum" is initiated by their ATP-dependent carboxylation to acetoacetate and 3-oxopentanoic acid, respectively...
  63. ncbi Total protein extraction with TCA-acetone
    Valérie Méchin
    UMR de Chimie Biologique, Thiverval Grignon, France
    Methods Mol Biol 355:1-8. 2007
    ..a large variety of plant tissues, based on simultaneous precipitation and denaturation with TCA and 2ME in cold acetone. We also describe protein solubilization prior to IEF, either in classical rod gels or in IPGs, using two ..
  64. pmc Carbonylation as a key reaction in anaerobic acetone activation by Desulfococcus biacutus
    Olga B Gutiérrez Acosta
    Department of Biology
    Appl Environ Microbiol 79:6228-35. 2013
    b>Acetone is activated by aerobic and nitrate-reducing bacteria via an ATP-dependent carboxylation reaction to form acetoacetate as the first reaction product...
  65. ncbi The cause of "acid-crash" and "acidogenic fermentations" during the batch acetone-butanol-ethanol (ABE-) fermentation process
    I S Maddox
    Institute of Technology and Engineering, Massey University, Palmerston North, New Zealand
    J Mol Microbiol Biotechnol 2:95-100. 2000
    ..which occasionally occurs in pH-uncontrolled batch fermentations resulting in premature cessation of ABE (acetone butanol) production...
  66. ncbi Production of acetone-butanol-ethanol (ABE) in direct fermentation of cassava by Clostridium saccharoperbutylacetonicum N1-4
    Vu Hong Thang
    Laboratory of Applied Microbiology, Department of Applied Biochemistry and Food Science, Faculty of Agriculture, Saga University, Honjo cho 1, Saga 840 8502, Japan
    Appl Biochem Biotechnol 161:157-70. 2010
    In this work, acetone-butanol-ethanol (ABE) fermentation characteristics of cassava starch and cassava chips when using Clostridium saccharoperbutylacetonicum N1-4 was presented...
  67. pmc A novel HPLC method reveals that precipitation of 2'-deoxyadenosine 5'-monophosphate with lithium perchlorate/acetone leads to base depurination
    David L Evers
    Department of Biophysics, Armed Forces Institute of Pathology, Rockville, MD 20850, USA
    Anal Biochem 370:255-7. 2007
  68. ncbi Comparison of the nutritional value and biological activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus
    F O Jimoh
    Department of Botany, University of Fort Hare, Alice 5700, South Africa
    Food Chem Toxicol 48:964-71. 2010
    The nutritional, phytochemical, antioxidant and antibacterial activities of the acetone, methanol and water extracts of the leaves of Solanum nigrum and Leonotis leonorus were investigated using standard analytical methods in order to ..
  69. ncbi Quantification of breath carbon disulphide and acetone following a single dose of disulfiram (Antabuse) using selected ion flow tube mass spectrometry (SIFT-MS)
    Roger N Bloor
    Academic Psychiatry Unit, Keele University Medical School, Academic Suite, Harplands Hospital, UK
    Addict Biol 11:163-9. 2006
    ..spectrometry (SIFT-MS) has been used to measure simultaneously the concentrations of both carbon disulphide and acetone in exhaled breath following the ingestion of a single dose of disulfiram (Antabuse)...
  70. ncbi Exhaled acetone as a new biomaker of heart failure severity
    Fabiana G Marcondes-Braga
    Laboratory of Heart Failure, Heart Institute InCor, Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo, Brazil
    Chest 142:457-66. 2012
    ..In a pilot study, we observed high levels of acetone in the exhaled breath of patients with HF...
  71. ncbi Simultaneous saccharification and fermentation of lignocellulosic residues pretreated with phosphoric acid-acetone for bioethanol production
    Hui Li
    Biochemical Engineering Lab, Department of Chemical and Biomolecular Engineering, KAIST, Yuseong Gu, Daejeon, Republic of Korea
    Bioresour Technol 100:3245-51. 2009
    Bermudagrass, reed and rapeseed were pretreated with phosphoric acid-acetone and used for ethanol production by means of simultaneous saccharification and fermentation (SSF) with a batch and fed-batch mode...
  72. ncbi Application of trichloroacetic acid-acetone precipitation method for protein extraction in bone tissue
    Cui Yong-Feng
    Department of Orthopedics, the First People s Hospital of Xiaoshan District, Hangzhou 311200, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 33:210-3. 2011
    To explore the feasibility and efficiency of extracting protein from bone tissue using trichloroacetic acid (TCA)-acetone precipitation method.
  73. ncbi Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet
    Sergei S Likhodii
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Ontario, Canada
    Ann Neurol 54:219-26. 2003
    The ketogenic diet (KD), a treatment for drug-resistant epilepsy, elevates brain acetone. Acetone has been shown to suppress experimental seizures...
  74. ncbi Stability of toluene and reduction of acetone to 2-propanol in homogenates of the human liver, brain and lungs
    Grzegorz Buszewicz
    Chair and Department of Forensic Medicine, Medical University of Lublin, ul Jaczewskiego 8, Lublin 20 090, Poland
    Forensic Sci Int 141:63-8. 2004
    ..were placed in the desiccator filled with vapours of rubber glue solvents and the concentrations of toluene, acetone and 2-propanol were determined during the 28-day storage at +25, +4 and -20 degrees C...
  75. ncbi Flexural properties of repaired heat-polymerising acrylic resin after wetting with monomer and acetone
    Canan Bural
    Department of Removable Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey
    Gerodontology 27:217-23. 2010
    ..Repair strength can be improved by treating fractured surfaces of a denture...
  76. ncbi In vivo chlorhexidine stabilization of hybrid layers of an acetone-based dentin adhesive
    M G Brackett
    Department of Oral Rehabilitation, School of Dentistry, Medical College of Georgia, Augusta, GA, USA
    Oper Dent 34:379-83. 2009
    ..The adhesive used was a single-bottle etch-and-rinse acetone-based product (Prime & Bond NT, Dentsply/Caulk)...
  77. ncbi Investigations on the structure of dimethyl sulfoxide and acetone in aqueous solution
    Sylvia E McLain
    Spallation Neutron Source and Center for Molecular Biophysics, Oak Ridge National Laboratory, PO Box 2008, Oak Ridge, Tennessee 37831 6475, USA
    J Chem Phys 127:174515. 2007
    Aqueous solutions of dimethyl sulfoxide (DMSO) and acetone have been investigated using neutron diffraction augmented with isotopic substitution and empirical potential structure refinement computer simulations...
  78. ncbi Detection of acetone processing of castor bean mash for forensic investigation of ricin preparation methods
    Helen W Kreuzer
    Pacific Northwest National Laboratory, 999 Battelle Blvd, Richland, WA 99352, USA
    J Forensic Sci 55:908-14. 2010
    ..One commonly described crude ricin preparation method is acetone extraction of crushed castor beans...
  79. ncbi Tsetse and other biting fly responses to Nzi traps baited with octenol, phenols and acetone
    S Mihok
    Med Vet Entomol 21:70-84. 2007
    Octenol (1-octen-3-ol), acetone, 4-methylphenol, 3-n-propylphenol, and other potential attractants (human urine, stable fly faeces), as well as guiacol, creosol (potential repellents), were tested as baits for biting flies in North ..
  80. ncbi Aminoacetone induces iron-mediated oxidative damage to isolated rat liver mitochondria
    Fernando Dutra
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av Prof Lineu Prestes 748, SP, CEP 05508 900, Brazil
    Arch Biochem Biophys 430:284-9. 2004
    ..These findings may contribute to clarify the role of accumulated AA and iron overload in the mitochondrial oxidative damage reportedly occurring in diabetes mellitus...
  81. ncbi pi-Acidic alkene ligand effects in Pd-catalysed cross-coupling processes: exploiting the interaction of dibenzylidene acetone (dba) and related ligands with Pd(0) and Pd(II)
    Ian J S Fairlamb
    Department of Chemistry, University of York, York, United Kingdom
    Org Biomol Chem 6:3645-56. 2008
    ..is to highlight the impressive results that can be obtained using pi-acidic alkene ligands, with a particular focus on dibenzylidene acetone (dba) derivatives. Other types of alkene ligands, e.g. macrocyclic alkenes, are also discussed.
  82. ncbi Aminoacetone induces oxidative modification to human plasma ceruloplasmin
    Fernando Dutra
    Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, CP 26077, 05513 970, Sao Paulo, SP, Brazil
    Chem Res Toxicol 18:755-60. 2005
    ..If operative in vivo, this reaction would impair the antioxidant role of CP and iron uptake by ferritin and hence contribute to intracellular iron-induced oxidative stress during AA accumulation in diabetes mellitus...
  83. ncbi Multiresidue pesticide analysis of ginseng powders using acetonitrile- or acetone-based extraction, solid-phase extraction cleanup, and gas chromatography-mass spectrometry/selective ion monitoring (GC-MS/SIM) or -tandem mass spectrometry (GC-MS/MS)
    Jon W Wong
    Center for Food Safety and Applied Nutrition, US Food and Drug Administration, HFS 706, 5100 Paint Branch Parkway, College Park, Maryland 20740 3835, USA
    J Agric Food Chem 58:5884-96. 2010
    ..method for the analysis of 168 pesticides in dried powdered ginseng has been developed using acetonitrile or acetone mixture (acetone/cyclohexane/ethyl acetate, 2:1:1 v/v/v) extraction, solid-phase extraction (SPE) cleanup with ..
  84. ncbi Acetone, butanol, and ethanol production from wastewater algae
    Joshua T Ellis
    Utah State University, Department of Biological Engineering, 4105 Old Main Hill, Logan, UT 84322 4105, USA
    Bioresour Technol 111:491-5. 2012
    b>Acetone, butanol, and ethanol (ABE) fermentation by Clostridium saccharoperbutylacetonicum N1-4 using wastewater algae biomass as a carbon source was demonstrated...
  85. ncbi Ethanol-, fasting-, and acetone-inducible cytochromes P-450 in rat liver: regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies
    I Johansson
    Department of Physiological Chemistry, Karolinska Institute, Stockholm, Sweden
    Biochemistry 27:1925-34. 1988
    Two major forms of hepatic microsomal cytochrome P-450 were purified from starved and acetone-treated rats. On the basis of amino acid sequence analysis, they were identified as P-450j and P-450b...
  86. ncbi Enhanced activity and enantioselectivity of a hyperthermophilic esterase from archaeon Aeropyrum pernix K1 by acetone treatment
    Fangdi Cong
    College of Life Sciences, Jilin University, Changchun 130012, People s Republic of China
    Appl Biochem Biotechnol 165:795-801. 2011
    ..of hyperthermophilic archaeon Aeropyrum pernix K1 esterase (APE1547) and its mutants, they were purified by acetone-treated method...
  87. ncbi Breath acetone concentration; biological variability and the influence of diet
    Patrik Spanel
    J Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Dolejskova 3, 182 23, Prague 8, Czech Republic
    Physiol Meas 32:N23-31. 2011
    Previous measurements of acetone concentrations in the exhaled breath of healthy individuals and the small amount of comparable data for individuals suffering from diabetes are briefly reviewed as a prelude to the presentation of new ..
  88. ncbi Antimutagenic activities of acetone and methanol fractions of Terminalia arjuna
    K Kaur
    Department of Botanical Land Environmental Sciences, Guru Nanak Dev University, Amritsar, India
    Food Chem Toxicol 40:1475-82. 2002
    The antimutagenic effect of benzene, chloroform, acetone and methanol fractions from Terminalia arjuna, a well-known medicinal plant, was determined against Acid Black dye, 2-aminofluorene (2AF) and 4-nitro-o-phenylenediamine (NPD) in ..
  89. ncbi Pathology of ocular irritation with acetone, cyclohexanol, parafluoroaniline, and formaldehyde in the rabbit low-volume eye test
    J K Maurer
    The Procter and Gamble Co, Cincinnati, Ohio, USA
    Toxicol Pathol 29:187-99. 2001
    ..Ten microl of acetone (ACT)...
  90. ncbi Structure of hydroxynitrile lyase from Manihot esculenta in complex with substrates acetone and chloroacetone: implications for the mechanism of cyanogenesis
    H Lauble
    Universitat Stuttgart, Institut fur Organische Chemie, Pfaffenwaldring 55, D 70569 Stuttgart, Germany
    Acta Crystallogr D Biol Crystallogr 57:194-200. 2001
    The crystal structures of hydroxynitrile lyase from Manihot esculenta (MeHNL) complexed with the native substrate acetone and substrate analogue chloroacetone have been determined and refined at 2.2 A resolution...
  91. ncbi Bacteriophage infections in the industrial acetone butanol (AB) fermentation process
    D T Jones
    Department of Microbiology, University of Otago, Dunedin, New Zealand
    J Mol Microbiol Biotechnol 2:21-6. 2000
    The reported incidence and effects of bacteriophage infections occurring in the industrial acetone butanol (AB) fermentation processes operated in the USA, Japan, and Puerto Rico during the earlier part of the twentieth century is ..
  92. pmc Wetting ability of an acetone/based etch&rinse adhesive after NaOCl-treatment
    Fatima S Aguilera
    Department of Dental Materials, School of Dentistry, Campus de Cartuja 18071, University of Granada, Spain
    Med Oral Patol Oral Cir Bucal 17:e644-8. 2012
    ..to evaluate the effect of sodium hypochlorite (NaOCl) treatment on surface dentin roughness (Ra) and contact angle (CA) when using Prime&Bond NT adhesive (PB NT)...
  93. ncbi Acetone precipitation of the scrapie agent results in successful recovery of PrP(Sc) but decreased infectivity
    J D Smith
    Virus and Prion Research Unit, National Animal Disease Center, USDA, Agricultural Research Service, Ames, Iowa, USA
    J Agric Food Chem 60:4758-62. 2012
    ..The current study was designed to evaluate acetone precipitation of the disease-associated form of the prion protein (PrP(Sc)) from brain homogenate derived from ..
  94. pmc Molecular basis of bilirubin UDP-glucuronosyltransferase induction in spontaneously diabetic rats, acetone-treated rats and starved rats
    L Braun
    Department of Medical Chemistry, Semmelweis University of Medicine, P O Box 260, H 1444 Budapest, Hungary
    Biochem J 336:587-92. 1998
    ..UDP-glucuronosyltransferase (UGT1A1) were investigated in livers of BioBreeding/Worcester diabetic, fasted and acetone-treated rats...
  95. pmc RNAi-mediated silencing of the HD-Zip gene HD20 in Nicotiana attenuata affects benzyl acetone emission from corollas via ABA levels and the expression of metabolic genes
    Delfina A Ré
    Department of Molecular Ecology, Max Planck Institute for Chemical Ecology, 07745, Jena, Germany
    BMC Plant Biol 12:60. 2012
    ..it has been previously associated with the regulation of ABA accumulation in leaves and the emission of benzyl acetone (BA; 4-phenyl-2-butanone) from night flowers. In this study, N...
  96. pmc A sub-ppm acetone gas sensor for diabetes detection using 10 nm thick ultrathin InN FETs
    Kun Wei Kao
    Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan
    Sensors (Basel) 12:7157-68. 2012
    An indium nitride (InN) gas sensor of 10 nm in thickness has achieved detection limit of 0.4 ppm acetone. The sensor has a size of 1 mm by 2.5 mm, while its sensing area is 0.25 mm by 2 mm...
  97. ncbi Genome shuffling of Clostridium acetobutylicum CICC 8012 for improved production of acetone-butanol-ethanol (ABE)
    Xiaofeng Gao
    Chengdu Institute of Biology, Chinese Academy of Sciences, China
    Curr Microbiol 65:128-32. 2012
    ..These results demonstrated the potential use of genome shuffling to microbial breeding which were difficult to deal with traditional methods...
  98. ncbi Toxicity study of di(2-ethylhexyl)phthalate (DEHP) in combination with acetone in rats
    M Dalgaard
    Institute of Food Safety and Toxicology, Danish Veterinary and Food Administration, Søborg
    Pharmacol Toxicol 86:92-100. 2000
    ..rats were dosed with di(2-ethylhexyl)phthalate (DEHP) by gavage and exposed to drinking water with or without acetone (0.5% wt/v in the 9-week study, 1.0% wt/v in the 4-week study)...
  99. ncbi Chemical constituents, antifungal and antioxidative effects of ajwain essential oil and its acetone extract
    Gurdip Singh
    Chemistry Department, DDU Gorakhpur University, Gorakhpur 273009, India
    J Agric Food Chem 52:3292-6. 2004
    ..8%), gamma-terpinene (23.2%), beta-pinene (1.7%), terpinene-4-ol (0.8%) whereas acetone extract of ajwain showed the presence of 18 identified components which account for 68.8% of the total amount...
  100. ncbi Chemical-specific adjustment factors for intraspecies variability of acetone toxicokinetics using a probabilistic approach
    Anna Karin Mörk
    Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Sci 116:336-48. 2010
    ..b>Acetone was used as a model substance...
  101. ncbi Sequential solubilization of proteins precipitated with trichloroacetic acid in acetone from cultured Catharanthus roseus cells yields 52% more spots after two-dimensional electrophoresis
    D I Jacobs
    Division of Pharmacognosy, Leiden Amsterdam Center of Drug Research, The Netherlands
    Proteomics 1:1345-50. 2001
    ..solubilization procedure for the solubilization of proteins after precipitation in trichloroacetic acid and acetone. The procedure includes solubilization with a conventional urea buffer followed by a stronger solubilizing buffer ..

Research Grants63

  1. REACTIVITY AND SELECTIVITY OF REACTIONS IN POLAR MEDIA
    PAUL GRIECO; Fiscal Year: 2002
    ..In the third part of this grant application we will examine unique solvent systems (e.g. Li2B12H12-acetone, MgB12H12-acetone) in hopes of finding new opportunities for altering transition states while accelerating ..
  2. A PF-GC for Environmental Health Breath Assessment
    Pavel Smejtek; Fiscal Year: 2004
    ..Major endogenous compounds in human breath are methane, methanol, ethanol, acetone, methyl acetate, and isoprene...
  3. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    ..Both sequenced strains were reported recently to have the genes for a potential acetone carboxylase, an enzyme that initiates the metabolism of acetone by converting it to acetoacetate...
  4. The role of IL-6 in jet fuel irritant dermatitis
    RANDLE MICHAEL GALLUCCI; Fiscal Year: 2010
    ..C57 mice will be exposed to the irritants JP8 jet fuel, as well as the well characterized irritants SLS, BKC, and acetone as a control...
  5. Hyaluronan in Epidermal Injury Responses
    Edward Maytin; Fiscal Year: 2009
    ..For this purpose, we have developed a new in vitro model of barrier injury (acetone applied to 3-D cultures of rat keratinocytes) to study mechanisms of inducible HA and epidermal responses to ..
  6. Detection of Ethanol and Interferents in Breath: Validation of a Novel Technology
    Timothy E Morey; Fiscal Year: 2011
    ..g., acetone, methanol), which commonly interfere with the function of present sensor technologies, and 3) establish mGC-MOS ..
  7. Neurologic and Reproductive Effects of Hexane on Workers
    S Katharine Hammond; Fiscal Year: 2012
    ..b>Acetone, which has been shown in animal studies to potentiate the effects of n-hexane and increase persistence, was added ..
  8. Enhancing Vein Graft Patency By Preserving Endothelial Function
    Igor V Voskresensky; Fiscal Year: 2012
    ..marking pens for vessel orientation is toxic to the endothelium secondary to conversion of isopropyl alcohol to acetone, a fixative...
  9. CONTROL OF CORPUS LUTEUM FUNCTION
    John Gadsby; Fiscal Year: 1990
    ..Initially, FP1 will be subjected to acetone precipitation to concentrate it and to remove steroids and prostaglandins...
  10. Organic Solvent Mixtures & Neuropsychological Outcomes
    Ellen Kirrane; Fiscal Year: 2002
    ..exposed to a variety of organic solvents including evaporative emissions from fuel and fuel exhaust, styrene and acetone during fiberglass work, paints and tars for waterproofing their traps...
  11. The role of ketones in the anticonvulsant mechanism of the ketogenic diet
    Karin Borges; Fiscal Year: 2009
    ..blood levels of ketones, including D-[unreadable]-hydroxybutyrate (D-BHB), acetoacetate, its degradation product acetone, and potentially L-[unreadable]-hydroxybutyrate (L-BHB)...
  12. DISPOSITION OF HYDRAZINES--SPECIES AND STRAIN EFFECTS
    Emerich Fiala; Fiscal Year: 1990
    ..activated by purified cytochrome P-450j, an isozyme inducible in the liver by administration of ethanol, acetone, isopropanol and other agents...
  13. INDUCTION AND MODE OF ACTION OF HEPATIC DRUG OXIDASE
    John Schenkman; Fiscal Year: 1992
    ..Insulin reverses these effects. The role of acetone as a mediator and its involvement in guconeogensis, under catalysis of RLM6, a diabetes induced P-450, will be ..
  14. CHEMOTHERAPEUTIC CONSEQUENCES OF GLUTATHIONE DEPLETION
    Todd Savarese; Fiscal Year: 1991
    ..will also be examined if other, more potent, GSH depleting agents can be found, such as phorone (disopropylidene acetone) or other polar solvents structurally related to NMF, that will have the same actions as NMF but greater efficacy...
  15. Detection of Ethanol in Human Breath: Mini-GC Use and Exhaled Breath Condensate
    Richard Melker; Fiscal Year: 2007
    ..g., acetone, methanol, toluene) that may interfere with alternative technologies used to detect ethanol in breath...
  16. Effects of ethanol and CYP2E1 on liver function
    Arthur Cederbaum; Fiscal Year: 2007
    ..in vivo and in vitro after treatment of mice and rats with ethanol or inducers of CYP2E1 such as pyrazole and acetone and in our HepG2 cell models which express human CYP2E1...
  17. Low Cost Multilayer Sensors for Breath Alcohol Analysis
    Stephanie Hooker; Fiscal Year: 2000
    ..To overcome cross-sensitivity to other gases that may be present in the breath (e.g., water vapor, acetone, toluene, and acetaldehyde), a sensor array will ultimately be prepared in Phase II...
  18. Novel Pharmaceutical Solvent - Water Separation System
    Stuart Nemser; Fiscal Year: 2005
    ..Examples include ethanol-water, IPA-water, acetone-water and THF-water...
  19. A Transcutaneous Nanotube Hydrogen Sensor
    KEAT ONG; Fiscal Year: 2005
    ..hydrogen concentration within potentially interfering gas mixtures that include CO2, O2, nitric acid, ammonia and acetone. {4} As needed, cross correlate the response of different nanoporous metal oxide sensors in an e-nose format to ..
  20. MOLECULAR DYNAMICS AT THE DENTIN/ADHESIVE INTERFACE
    Paulette Spencer; Fiscal Year: 2002
    ..encapsulation of exposed collagen in comparison to etched dentin treated with stabilizing solvents, specifically acetone and HEMA; test the hypothesis that self-etching primers provide stronger dentin/adhesive bonds in comparison to ..
  21. ORAL CARCINOGENESIS, VITAMIN A AND RETINOIDS
    Gerald Shklar; Fiscal Year: 1980
    ..pouch epidermoid carcinoma induced by DMBA in oil and the hamster tongue epidermoid carcinoma induced by DMBA in acetone. Delayed carcinogenesis will be evaluated by delayed appearance histologically of dysplasia, carcinoma-in-situ ..
  22. MOLECULAR BASIS FOR CLEAVAGE
    Keigi Fujiwara; Fiscal Year: 1980
    ..Rapid freezing is done using Heuser's apparatus and freeze-substitution will be done by cold acetone in the presence of OsO4.
  23. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  24. Elevated potassium ion in lacrimal fluid and the health of the ocular surface
    John Ubels; Fiscal Year: 2009
    ..If the high potassium in tears is important for the health of the ocular surface, this information will be useful in the development of improved treatments for dry eye disease. ..
  25. Determinants of the Durability of Resin-Dentin Bonds
    David Pashley; Fiscal Year: 2006
    ..This should provide important new insight into designing more durable resin-dentin bonds that can justify the placement of resin-based posterior composites. ..
  26. ROLE OF TGFBETA IN CORNEAL STROMAL WOUND HEALING
    James V Jester; Fiscal Year: 2010
    ....
  27. KERATOCYTE CRYSTALLIN PROTEINS AND CORNEAL TRANSPARENCY
    JAMES JESTER; Fiscal Year: 2003
    ....
  28. Analysis of Lacrimal Gland by Laser Microdissection
    John Ubels; Fiscal Year: 2003
    ..abstract_text> ..
  29. THE ROLE OF RETINOIDS IN LACRIMAL GLAND FUNCTION
    John Ubels; Fiscal Year: 2002
    ..abstract_text> ..
  30. THERMODYNAMICS OF BIOCHEMICAL SYSTEMS
    ROBERT ALBERTY; Fiscal Year: 2005
    ..This quantitative treatment of the literature data on biochemical reactions will uncover errors because deltafG'0 values can be determined by use of two or more biochemical reactions, which should give the same answer. ..
  31. The 17th Annual Conference of the International Society of Exposure of Analysis
    Clifford Weisel; Fiscal Year: 2007
    ..The primary outcome of the meeting will be the advancement of knowledge of human exposure science. [unreadable] [unreadable] [unreadable] [unreadable]..
  32. Effects of Ethanol on Pancreas Regeneration
    Dahn Clemens; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  33. GLYCOSIDASES AS RELATED TO SPHINGOLIPIDOSES
    Yu Teh Li; Fiscal Year: 2008
    ..Our ultimate goal is to produce recombinant enzymes and make these biomedically useful glycosidases available to investigators in various fields. ..
  34. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  35. Drug Abuse, Social Decision-Making, and Sex-Related Functional Brain Asymmetry
    DANIEL T TRANEL; Fiscal Year: 2010
    ..abstract_text> ..
  36. PAIN, OPIOID ANALGESIA AND BLOOD PRESSURE CONTROL
    Bradley Taylor; Fiscal Year: 2002
    ..The results of these studies will facilitate our understanding of the mechanisms that contribute to chronic pain in the hypertensive patient. ..
  37. The Effect of a Probiotic on Hepatic Steatosis
    Steven Solga; Fiscal Year: 2004
    ..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
  38. Oligopyrrole-based Anion Binding Agents
    Jonathan L Sessler; Fiscal Year: 2010
    ..abstract_text> ..
  39. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  40. ENERGY RESTRICTION, CELL SIGNALING AND CANCER PREVENTION
    Diane Birt; Fiscal Year: 2001
    ..The dependence of the biochemical events modified in Aims 2-4 on corticosterone will be assessed by parallel studies in sham and adrenalectomized mice. ..
  41. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  42. ETHANOL OXIDATION EFFECTS ON EGF SIGNAL TRANSDUCTION
    Dahn Clemens; Fiscal Year: 2001
    ....
  43. ALCOHOL OXYGEN RADICAL INTERACTIONS AS DETECTED BY ESR
    Arthur Cederbaum; Fiscal Year: 2001
    ..These studies will provide new information on the ability of NO to modulate CYP2El catalytic activity, generation of reactive intermediates, and ethanol and PUFA toxicity. ..
  44. Microbial metabolism of aliphatic alkenes & epoxides
    SCOTT ENSIGN; Fiscal Year: 2008
    ..We intend to further our work on the central roles of carboxylation and novel cofactors/enzymes in bacterial hydrocarbon/epoxide/ketone metabolism by pursuing the biochemical, structural, and genetic characterization of these processes. ..
  45. Epidemiologic Evaluation of Perfluorooctyl Compounds
    James Raymer; Fiscal Year: 2003
    ..If the exposure effect is limited to a sensitive subset of the general population, our study is more likely to detect an association compared to studies that sample on PFOA/PFOS exposure status in an occupational setting. ..
  46. Vasopressin Cytotoxicity in Inherited Diabetes Insipidus
    DAVID COOL; Fiscal Year: 2005
    ..abstract_text> ..
  47. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  48. ISEA 2004 Conference
    Junfeng Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  49. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  50. CO-CARCINOGENIC ACTIVITY OF NITROSAMINE METABOLITES
    Lisa Peterson; Fiscal Year: 2006
    ..In addition, this mechanism is likely applicable to other unsymmetric nitrosamines as well as carcinogenic mixtures such as tobacco smoke, a known human carcinogen. ..
  51. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  52. Regional Hypoxic Pulmonary Vasoconstriction
    MICHAEL HLASTALA; Fiscal Year: 2006
    ..The results of the research will provide a more detailed understanding of the local and cellular mechanisms responsible for HPVR heterogeneity and mechanisms of development of disease in the mammalian lung. [unreadable] [unreadable]..
  53. Polytene chromosomes of Culex pipiens mosquito complex
    Anthony Cornel; Fiscal Year: 2004
    ..p. pipiens, Cx. p. quinquefasciatus and Cx. p. molestus and 2) Determine chromosomal homologies between Cx. p. pipiens, Cx. p. quinquefasciatus and Cx. p. molestus. ..
  54. ALCOHOL AND PYRAZOLE REACTION AND METABOLISM BY CYP2E1
    Arthur Cederbaum; Fiscal Year: 2006
    ..It is hoped that such studies in hepatocyte and HepG2 cell culture models and in-vivo models, will help to define further the biochemical and toxicological actions of CYP2E1 and its role in alcohol-induced liver injury. ..
  55. Glycation and mu dicarbonyls in diabetic complications
    Paul Beisswenger; Fiscal Year: 2006
    ..These exciting research projects, and new ones on the horizon, combined with the proposed mentoring/training program offers real opportunities of attracting and rewarding a new generation of clinical investigators. ..
  56. Ultraviolet-C Therapy for Onychomycosis
    MICHAEL HAMBLIN; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  57. Gender differences in liver IL-6R expression
    RANDLE GALLUCCI; Fiscal Year: 2007
    ..By exposing ethanol- consuming rats to IL-6R agonists, it should be possible to correlate damage with receptor activation. [unreadable] [unreadable] [unreadable]..
  58. Mapping the Binding Surfaces of Ras and Related GTPases
    Carla Mattos; Fiscal Year: 2007
    ..The goal is to provide key information for ligand design and discovery that is based on multiple structures that offer multiple perspectives. [unreadable] [unreadable]..
  59. Macrophage Targeted Photodynamic Therapy
    MICHAEL HAMBLIN; Fiscal Year: 2004
    ....
  60. IMPROVEMENT OF PREVENTIVE AND RESTORATIVE MATERIALS
    RAFAEL BOWEN; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  61. Identification of an IL-6 induced keratinocyte motogen
    RANDLE GALLUCCI; Fiscal Year: 2008
    ..The results of these experiments will hopefully lead to the eventual development of a useful treatment for chronic wounds. ..