Top Publications

  1. ncbi Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study
    Javier Cortes
    Vall d Hebron University Hospital, Vall d Hebron Institute of Oncology, Barcelona, Spain
    Lancet 377:914-23. 2011
  2. ncbi The major Vibrio cholerae autoinducer and its role in virulence factor production
    Douglas A Higgins
    Department of Molecular Biology
    Nature 450:883-6. 2007
  3. pmc PEEK biomaterials in trauma, orthopedic, and spinal implants
    Steven M Kurtz
    Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Biomaterials 28:4845-69. 2007
  4. pmc The cytochrome P450 enzyme CYP96A15 is the midchain alkane hydroxylase responsible for formation of secondary alcohols and ketones in stem cuticular wax of Arabidopsis
    Stephen Greer
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
    Plant Physiol 145:653-67. 2007
  5. ncbi Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
    Christopher K Savile
    Codexis, Incorporated, 200 Penobscot Drive, Redwood City, CA 94063, USA
    Science 329:305-9. 2010
  6. ncbi The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    Mary Ann Jordan
    Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 93106 9610, USA
    Mol Cancer Ther 4:1086-95. 2005
  7. pmc Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
    George Kokotos
    Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece
    J Med Chem 53:3602-10. 2010
  8. pmc Ketones suppress brain glucose consumption
    Joseph C Lamanna
    Department of Anatomy, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Exp Med Biol 645:301-6. 2009
  9. pmc Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis
    Athena Kalyvas
    Center for Research in Neuroscience, McGill University Health Center Research Institute, Livingston Hall, Room L7 210, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
    Brain 132:1221-35. 2009
  10. pmc Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 114:130-41. 2010

Detail Information

Publications310 found, 100 shown here

  1. ncbi Eribulin monotherapy versus treatment of physician's choice in patients with metastatic breast cancer (EMBRACE): a phase 3 open-label randomised study
    Javier Cortes
    Vall d Hebron University Hospital, Vall d Hebron Institute of Oncology, Barcelona, Spain
    Lancet 377:914-23. 2011
    ..Eribulin mesilate is a non-taxane microtubule dynamics inhibitor with a novel mode of action. We aimed to compare overall survival of heavily pretreated patients receiving eribulin versus currently available treatments...
  2. ncbi The major Vibrio cholerae autoinducer and its role in virulence factor production
    Douglas A Higgins
    Department of Molecular Biology
    Nature 450:883-6. 2007
    ..These findings suggest that CAI-1 could be used as a therapy to prevent cholera infection and, furthermore, that strategies to manipulate bacterial quorum sensing hold promise in the clinical arena...
  3. pmc PEEK biomaterials in trauma, orthopedic, and spinal implants
    Steven M Kurtz
    Exponent, Inc, 3401 Market Street, Suite 300, Philadelphia, PA 19104, USA
    Biomaterials 28:4845-69. 2007
    ..For mature fields, such as total joint replacements and fracture fixation implants, radiolucency is an attractive but not necessarily critical material feature...
  4. pmc The cytochrome P450 enzyme CYP96A15 is the midchain alkane hydroxylase responsible for formation of secondary alcohols and ketones in stem cuticular wax of Arabidopsis
    Stephen Greer
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1
    Plant Physiol 145:653-67. 2007
    ..on the inflorescence stems of Arabidopsis (Arabidopsis thaliana) is dominated by alkanes, secondary alcohols, and ketones, all thought to be formed sequentially in the decarbonylation pathway of wax biosynthesis...
  5. ncbi Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture
    Christopher K Savile
    Codexis, Incorporated, 200 Penobscot Drive, Redwood City, CA 94063, USA
    Science 329:305-9. 2010
    ..This work underscores the maturation of biocatalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals...
  6. ncbi The primary antimitotic mechanism of action of the synthetic halichondrin E7389 is suppression of microtubule growth
    Mary Ann Jordan
    Molecular, Cellular, and Developmental Biology, University of California Santa Barbara, 93106 9610, USA
    Mol Cancer Ther 4:1086-95. 2005
    ..The result is formation of abnormal mitotic spindles that cannot pass the metaphase/anaphase checkpoint...
  7. pmc Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2
    George Kokotos
    Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece
    J Med Chem 53:3602-10. 2010
    ..001 while inhibiting the other intracellular GIVA cPLA(2) and GV sPLA(2) at least 90 times less potently. Hexa- and octafluoro ketones were also found to be potent inhibitors of GVIA iPLA(2); however, they are not selective.
  8. pmc Ketones suppress brain glucose consumption
    Joseph C Lamanna
    Department of Anatomy, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Adv Exp Med Biol 645:301-6. 2009
    The brain is dependent on glucose as a primary energy substrate, but is capable of utilizing ketones such as beta-hydroxybutyrate (beta HB) and acetoacetate (AcAc), as occurs with fasting, prolonged starvation or chronic feeding of a ..
  9. pmc Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis
    Athena Kalyvas
    Center for Research in Neuroscience, McGill University Health Center Research Institute, Livingston Hall, Room L7 210, 1650 Cedar Ave, Montreal, Quebec, Canada H3G 1A4
    Brain 132:1221-35. 2009
    ..Our results therefore suggest that iPLA(2) might be an excellent target to block for the treatment of CNS autoimmune diseases, such as multiple sclerosis...
  10. pmc Ketones prevent synaptic dysfunction induced by mitochondrial respiratory complex inhibitors
    Do Young Kim
    Barrow Neurological Institute and St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    J Neurochem 114:130-41. 2010
    b>Ketones have previously shown beneficial effects in models of neurodegenerative disorders, particularly against associated mitochondrial dysfunction and cognitive impairment...
  11. ncbi Polyetheretherketone as a biomaterial for spinal applications
    Jeffrey M Toth
    Department of Orthopaedic Surgery, Medical College of Wisconsin, 9200 W Wisconsin Ave, Box 26099, Milwaukee, WI 53226 0099, USA
    Biomaterials 27:324-34. 2006
    ..Based on these results, the polymeric biomaterial PEEK may be a useful biomaterial for interbody fusion cages due to the polymer's increased radiolucency and decreased stiffness...
  12. pmc Eribulin binds at microtubule ends to a single site on tubulin to suppress dynamic instability
    Jennifer A Smith
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California, Santa Barbara, California 93106, USA
    Biochemistry 49:1331-7. 2010
    ..Overall, our results indicate that eribulin binds with high affinity to microtubule plus ends and thereby suppresses dynamic instability...
  13. pmc The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA
    Robert C Kelly
    Department of Molecular Biology, Princeton University, New Jersey, USA
    Nat Chem Biol 5:891-5. 2009
    ..cholerae responds to amino-CAI-1 as well as CAI-1, whereas other CAI-1 variants do not elicit a quorum-sensing response. Thus, both CAI-1 and amino-CAI-1 have potential as lead molecules in the development of an anticholera treatment...
  14. pmc Mechanism of Vibrio cholerae autoinducer-1 biosynthesis
    Yunzhou Wei
    Department of Molecular Biology and Department of Chemistry, Princeton University, New Jersey 08544, United States
    ACS Chem Biol 6:356-65. 2011
    ..SAM is the substrate for the synthesis of at least three different classes of quorum-sensing signal molecules, indicating that bacteria have evolved a strategy to leverage an abundant substrate for multiple signaling purposes...
  15. ncbi The ketogenic diet changes metabolite levels in hippocampal extracellular fluid
    Ramakrishna Samala
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    Neurochem Int 58:5-8. 2011
    ..This work will now enable other researchers to mimic the hippocampal extracellular environment in experiments aimed at deciphering the mechanisms of the KD...
  16. ncbi Newly synthesized curcumin analog has improved potential to prevent colorectal carcinogenesis in vivo
    Hiroyuki Shibata
    Department of Clinical Oncology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
    Cancer Sci 100:956-60. 2009
    ..It was demonstrated that the number of beta-catenin-positive adenoma cells in Apc(580D/+) mice fed GO-Y030 was reduced...
  17. pmc Quorum sensing contributes to natural transformation of Vibrio cholerae in a species-specific manner
    Gaia Suckow
    Global Health Institute, Ecole Polytechnique Fe de rale de Lausanne EPFL, Lausanne, Switzerland
    J Bacteriol 193:4914-24. 2011
    ..We suggest that CAI-1 can be considered a competence pheromone...
  18. ncbi In vitro and in vivo anticancer activities of synthetic macrocyclic ketone analogues of halichondrin B
    M J Towle
    Department of Anticancer Research Eisai Research Institute. Andover, Massachusetts 01810, USA
    Cancer Res 61:1013-21. 2001
  19. ncbi Sealing plant surfaces: cuticular wax formation by epidermal cells
    Lacey Samuels
    Department of Botany, University of British Columbia, Vancouver, BC V6T1Z4, Canada
    Annu Rev Plant Biol 59:683-707. 2008
    ..the subsequent modification of the elongated products into primary alcohols, wax esters, secondary alcohols, and ketones, shedding light on the enzymes involved in these pathways...
  20. ncbi Phase I study of eribulin mesylate administered once every 21 days in patients with advanced solid tumors
    Antoinette R Tan
    The Cancer Institute of New Jersey, New Brunswick, New Jersey 08901, USA
    Clin Cancer Res 15:4213-9. 2009
    ..To evaluate the maximum tolerated dose (MTD), dose-limiting toxicities (DLT), and pharmacokinetics of eribulin mesylate (E7389), a halichondrin B analogue, administered every 21 days in patients with advanced solid tumors...
  21. pmc Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules
    Wai Leung Ng
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 107:5575-80. 2010
    ..We suggest that rationally designed ligands can be employed to study, and ultimately to control, histidine kinase activity...
  22. pmc Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes
    Imri Ben-Israel
    Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, Faculty of Agriculture, Food, and Environment, Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant Physiol 151:1952-64. 2009
    ..Furthermore, heterologous expression of MKS2 in Escherichia coli resulted in the production of methylketones in this host...
  23. ncbi Phase II study of eribulin mesylate, a halichondrin B analog, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    Linda T Vahdat
    Weill Medical College of Cornell University, Division of Hematology Oncology, New York, NY 10021, USA
    J Clin Oncol 27:2954-61. 2009
    ..This open-label, single-arm, phase II study evaluated efficacy and tolerability of eribulin in heavily pretreated patients with metastatic breast cancer (MBC)...
  24. ncbi Phase II study of the halichondrin B analog eribulin mesylate in patients with locally advanced or metastatic breast cancer previously treated with an anthracycline, a taxane, and capecitabine
    Javier Cortes
    Vall d Hebron University Hospital, Barcelona, Spain
    J Clin Oncol 28:3922-8. 2010
  25. pmc The Legionella autoinducer synthase LqsA produces an alpha-hydroxyketone signaling molecule
    Thomas Spirig
    Institute of Microbiology, ETH Zurich, Zurich, Switzerland
    J Biol Chem 283:18113-23. 2008
    ..Thus, LqsA and CqsA belong to a family of pyridoxal 5'-phosphate-dependent autoinducer synthases, which produce the alpha-hydroxyketone signaling molecules LAI-1 and CAI-1...
  26. pmc Inhibition of centromere dynamics by eribulin (E7389) during mitotic metaphase
    Tatiana Okouneva
    Department of Molecular, Cellular, and Developmental Biology and Neuroscience Research Institute, University of California Santa Barbara, Santa Barbara, CA 93106, USA
    Mol Cancer Ther 7:2003-11. 2008
    ..The strong correlation between suppression of kinetochore-microtubule dynamics and mitotic arrest indicates that the primary mechanism by which eribulin blocks mitosis is suppression of spindle microtubule dynamics...
  27. ncbi The electron beam deposition of titanium on polyetheretherketone (PEEK) and the resulting enhanced biological properties
    Cheol Min Han
    Department of Materials Science and Engineering and Hybrid Materials Division in WCU Program, Seoul National University, Seoul 151 744, Republic of Korea
    Biomaterials 31:3465-70. 2010
    ..These in vitro and in vivo results suggested that the e-beam deposited Ti coating significantly improved the potential of PEEK for hard tissue applications...
  28. ncbi Response of primary fibroblasts and osteoblasts to plasma treated polyetheretherketone (PEEK) surfaces
    D Briem
    Department of Trauma, Hand and Reconstructive Surgery, School of Medicine, Hamburg University, Martinistr 52, D 20246, Hamburg, Germany
    J Mater Sci Mater Med 16:671-7. 2005
    ..These results show that chemically inert materials such as PEEK may be modified specifically through the methods of plasma technology in order to improve biocompatibility...
  29. ncbi Ketones: metabolism's ugly duckling
    Theodore B VanItallie
    Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, St Luke s Roosevelt Hospital Center in New York City, 10025, USA
    Nutr Rev 61:327-41. 2003
    b>Ketones were first discovered in the urine of diabetic patients in the mid-19th century; for almost 50 years thereafter, they were thought to be abnormal and undesirable by-products of incomplete fat oxidation...
  30. ncbi Eribulin induces irreversible mitotic blockade: implications of cell-based pharmacodynamics for in vivo efficacy under intermittent dosing conditions
    Murray J Towle
    Division of Biology, Eisai Inc, Andover, Massachusetts, USA
    Cancer Res 71:496-505. 2011
  31. pmc Clinical review: ketones and brain injury
    Hayden White
    Department of Intensive Care, Griffi ths University, Logan Hospital, Meadowbrook, Queensland 4131, Australia
    Crit Care 15:219. 2011
    Although much feared by clinicians, the ability to produce ketones has allowed humans to withstand prolonged periods of starvation. At such times, ketones can supply up to 50% of basal energy requirements...
  32. ncbi Mechanical properties and in vitro response of strontium-containing hydroxyapatite/polyetheretherketone composites
    K L Wong
    Department of Orthopaedics and Traumatology, The University of Hong Kong, Hong Kong
    Biomaterials 30:3810-7. 2009
    ..Strontium, in the form of strontium-containing hydroxyapatite (Sr-HA), was confirmed to enhance bioactivity in the PEEK composites...
  33. pmc Fluoroketone inhibition of Ca(2+)-independent phospholipase A2 through binding pocket association defined by hydrogen/deuterium exchange and molecular dynamics
    Yuan Hao Hsu
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093 0601, USA
    J Am Chem Soc 135:1330-7. 2013
    ..The discovery of the precise binding mode of FK ligands to the iPLA(2) should greatly improve our ability to design new inhibitors with higher potency and selectivity...
  34. ncbi Solis cage (PEEK) for anterior cervical fusion: preliminary radiological results with emphasis on fusion and subsidence
    Arvind G Kulkarni
    Spine Division, Department of Orthopaedics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074
    Spine J 7:205-9. 2007
    ..Recent literature has raised some apprehensions with regard to the usage of cervical cages...
  35. pmc Synthesis of substituted isoquinolines utilizing palladium-catalyzed α-arylation of ketones
    Timothy J Donohoe
    Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom
    Proc Natl Acad Sci U S A 109:11605-8. 2012
    ..This powerful route to polysubstituted isoquinolines, which is not limited to electron rich moieties, also allows rapid access to analogues of biologically active compounds...
  36. ncbi Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?
    J M Mathews
    Research Triangle Institute, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Appl Pharmacol 146:255-60. 1997
    ..In addition to hexane, short-chain methyl ketones were particularly affected, and percentage increases in response to inhibition were inversely related to chain ..
  37. ncbi Advances in therapy: eribulin improves survival for metastatic breast cancer
    Patrick G Morris
    Breast Cancer Medicine Service, Memorial Sloan Kettering Cancer Center, Evelyn H Lauder Breast Center, New York, USA
    Anticancer Drugs 21:885-9. 2010
    ..Future studies will investigate the potential role of eribulin in other settings, including for early breast cancer, to ascertain how to optimally incorporate this new agent into current treatment paradigms...
  38. pmc Metal-free catalytic enantioselective C-B bond formation: (pinacolato)boron conjugate additions to α,β-unsaturated ketones, esters, Weinreb amides, and aldehydes promoted by chiral N-heterocyclic carbenes
    Hao Wu
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States
    J Am Chem Soc 134:8277-85. 2012
    ..Acyclic and cyclic α,β-unsaturated ketones, as well as acyclic esters, Weinreb amides, and aldehydes, can serve as suitable substrates; the desired β-boryl ..
  39. ncbi Comparison of neuropathy-inducing effects of eribulin mesylate, paclitaxel, and ixabepilone in mice
    Krystyna M Wozniak
    Johns Hopkins Brain Science Institute, Baltimore, Maryland 21205, USA
    Cancer Res 71:3952-62. 2011
    ..Overall, our findings indicate that eribulin mesylate induces less neuropathy in mice than paclitaxel or ixabepilone at equivalent MTD-based doses...
  40. pmc Novel anti-Prelog stereospecific carbonyl reductases from Candida parapsilosis for asymmetric reduction of prochiral ketones
    Yao Nie
    Center for Advanced Biotechnology and Medicine, Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey 08854, USA
    Org Biomol Chem 9:4070-8. 2011
    ..Our study also showed that genomic mining is a powerful tool for the discovery of new enzymes...
  41. pmc Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit
    Megan E Bolitho
    Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
    Bioorg Med Chem 19:6906-18. 2011
    ..The molecules described in this manuscript are anticipated to serve as valuable tools in the study of quorum sensing in Vibrio cholerae and provide new leads in the development of an antivirulence therapy against this human pathogen...
  42. ncbi Bioreduction of α,β-unsaturated ketones and aldehydes by non-conventional yeast (NCY) whole-cells
    Marta Goretti
    Department of Applied Biology and Industrial Yeasts Collection DBVPG, University of Perugia, Borgo XX Giugno 74, 06121 Perugia, Italy
    Bioresour Technol 102:3993-8. 2011
    The bioreduction of α,β-unsaturated ketones (ketoisophorone, 2-methyl- and 3-methyl-cyclopentenone) and aldehydes [(S)-(-)-perillaldehyde and α-methyl-cinnamaldehyde] by 23 "non-conventional" yeasts (NCYs) belonging to 21 species of ..
  43. ncbi Ecological role of a seaweed secondary metabolite for a colonizing bacterial community
    Frank Persson
    Department of Cell and Molecular Biology, Microbiology, University of Gothenburg, Goteborg, Sweden
    Biofouling 27:579-88. 2011
    ..5 μg cm⁻²) and the evenness (5 μg cm⁻²) of the bacterial communities. Altogether, the results emphasize the role of secondary metabolites for control of the density and structure of seaweed-associated bacterial communities...
  44. ncbi Antifungal unsaturated cyclic Mannich ketones and amino alcohols: study of mechanism of action
    Bela Kocsis
    University of Pecs, Faculty of Medicine, Department of Medical Microbiology and Immunology, H 7624 Pecs, Szigeti ut 12, Hungary
    Eur J Med Chem 44:1823-9. 2009
    The antifungal activity of some known unsaturated Mannich ketones and their amino alcohols has been reported and the mechanism of antifungal action has been studied...
  45. pmc Cyclic AMP post-transcriptionally regulates the biosynthesis of a major bacterial autoinducer to modulate the cell density required to activate quorum sensing
    Weili Liang
    Morehouse School of Medicine Department of Microbiology, Biochemistry and Immunology, 720 Westview Dr, SW Atlanta, GA 30310, United States
    FEBS Lett 582:3744-50. 2008
    ..Lowering intracellular cAMP levels by addition of d-glucose increased the cell density required to activate HapR. These results indicate that cAMP acts as a quorum modulator...
  46. ncbi Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: indole synthesis from anilines and ketones
    Ye Wei
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore
    J Am Chem Soc 134:9098-101. 2012
    ..The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.
  47. pmc Engineering of bacterial methyl ketone synthesis for biofuels
    Ee Been Goh
    Joint BioEnergy Institute, Emeryville, California, USA
    Appl Environ Microbiol 78:70-80. 2012
    We have engineered Escherichia coli to overproduce saturated and monounsaturated aliphatic methyl ketones in the C₁₁ to C₁₅ (diesel) range; this group of methyl ketones includes 2-undecanone and 2-tridecanone, which are of ..
  48. ncbi Insights into the biosynthesis of the Vibrio cholerae major autoinducer CAI-1 from the crystal structure of the PLP-dependent enzyme CqsA
    Nasrin Jahan
    Centre for Biomolecular Sciences, University of St Andrews, UK
    J Mol Biol 392:763-73. 2009
    ..It is proposed that a region of structure that is disordered in the apo structure is involved in the release of product. While not confirming if CqsA alone is able to synthesize CAI-1, these results suggest possible synthetic routes...
  49. ncbi Bacterial gene regulation by alpha-hydroxyketone signaling
    André Tiaden
    Institute of Molecular Life Sciences, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Trends Microbiol 18:288-97. 2010
    ..The lqs/cqs gene cluster is present in several environmental bacteria, suggesting that AHKs are widely used for cell-cell signaling...
  50. ncbi Comparison of polyetheretherketone cages with femoral cortical bone allograft as a single-piece interbody spacer in transforaminal lumbar interbody fusion
    Aaron R Cutler
    Department of Neurosurgery, New York Medical College, St Vincent s Hospital Manhattan, New York, New York 10595, USA
    J Neurosurg Spine 5:534-9. 2006
    ..The authors compared the clinical and radiographic outcomes of patients who underwent TLIF with pedicle screw fixation, in whom either a PEEK cage or an FCA was placed as an interbody spacer...
  51. ncbi Synthesis and biological evaluation of certain alpha,beta-unsaturated ketones and their corresponding fused pyridines as antiviral and cytotoxic agents
    H I El-Subbagh
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
    J Med Chem 43:2915-21. 2000
    ..In addition, compounds 26, 33, and 35 proved to be of moderate selectivity toward leukemia cell lines. The pyrano[3,2-c]pyridines heterocyclic system proved to be the most active antitumors among the investigated heterocycles...
  52. ncbi Outcomes of interbody fusion cages used in 1 and 2-levels anterior cervical discectomy and fusion: titanium cages versus polyetheretherketone (PEEK) cages
    Chi Chien Niu
    Department of Orthopedics Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan, Taiwan
    J Spinal Disord Tech 23:310-6. 2010
    ..A prospective study was performed in case with cervical spondylosis who underwent anterior cervical discectomy and fusion (ACDF) with titanium or polyetheretherketone (PEEK) cages...
  53. ncbi An expeditious synthesis of DPD and boron binding studies
    Martin F Semmelhack
    Departments of Chemistry and Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Org Lett 7:569-72. 2005
    ..reaction: see text]..
  54. pmc Subsidence and nonunion after anterior cervical interbody fusion using a stand-alone polyetheretherketone (PEEK) cage
    Jae Jun Yang
    Depatment of Orthopaedic Surgery, Seoul National University College of Medicine, Seoul, Korea
    Clin Orthop Surg 3:16-23. 2011
    ..The purposes of the present study are to evaluate the subsidence and nonunion that occurred after anterior cervical discectomy and fusion using a stand-alone intervertebral cage and to analyze the risk factors for the complications...
  55. pmc Ketones and lactate increase cancer cell "stemness," driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    Ubaldo E Martinez-Outschoorn
    The Jefferson Stem Cell Biology and Regenerative Medicine Center, Thomas Jefferson University, Philadelphia, PA, USA
    Cell Cycle 10:1271-86. 2011
    Previously, we showed that high-energy metabolites (lactate and ketones) "fuel" tumor growth and experimental metastasis in an in vivo xenograft model, most likely by driving oxidative mitochondrial metabolism in breast cancer cells...
  56. ncbi Polyetheretherketone--cytotoxicity and mutagenicity in vitro
    A Katzer
    ENDO Klinik Hamburg, Germany
    Biomaterials 23:1749-59. 2002
    ..0 microg/ml). Therefore, in summary, the study produced no evidence of cell damage caused by PEEK...
  57. ncbi Preliminary experience using a polyetheretherketone (PEEK) cage in the treatment of cervical disc disease
    Der Yang Cho
    Department of Neurosurgery, China Medical College Hospital, Taichung, Taiwan, Republic of China
    Neurosurgery 51:1343-49; discussion 1349-50. 2002
    ..We investigated the effectiveness of a new material, polyetheretherketone (PEEK), in a spinal cage used in performing cervical spinal fusion for the correction of cervical kyphosis...
  58. ncbi A unique urinary constituent, 6-hydroxy-6-methyl-3-heptanone, is a pheromone that accelerates puberty in female mice
    M V Novotny
    Department of Chemistry, Indiana University, Bloomington, IN 47405, USA
    Chem Biol 6:377-83. 1999
    ..We investigated the chemical nature of the urinary fractions that are responsible for the characteristic uterine weight increases...
  59. ncbi A comparison of changes over time in cervical foraminal height after tricortical iliac graft or polyetheretherketone cage placement following anterior discectomy
    Suat E Celik
    Department of Neurosurgery, Beyoglu State Hospital, Istanbul, Turkey
    J Neurosurg Spine 6:10-6. 2007
    ..To their knowledge, this prospective study is the first in which foraminal height changes over time are compared following the placement of a tricortical graft or a polyetheretherketone (PEEK) cage...
  60. ncbi Efficacy of anterior cervical fusion: comparison of titanium cages, polyetheretherketone (PEEK) cages and autogenous bone grafts
    Yu Cheng Chou
    Division of Functional Neuroscience, Buddhist Tzu Chi General Hospital, Hualien, Taiwan
    J Clin Neurosci 15:1240-5. 2008
    ..3% in group B, and 84.85% in group C. The fusion rates after 1 year in groups A, B, and C were 46.51%, 100% and 100%, respectively. The PEEK cage is a viable alternative to autogenous tricortical bone grafts in anterior cervical fusion...
  61. ncbi Delineation of the interactions between the chemotherapeutic agent eribulin mesylate (E7389) and human CYP3A4
    Z Y Zhang
    Department of Drug Disposition, Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA
    Cancer Chemother Pharmacol 62:707-16. 2008
  62. ncbi Multilevel cervical fusion without plates, screws or autogenous iliac crest bone graft
    Mehmet Nusret Demircan
    GATA Haydarpasa Training Hospital, Department of Neurosurgery, Istanbul, Turkey
    J Clin Neurosci 14:723-8. 2007
  63. ncbi Treatment of multilevel cervical fusion with cages
    Der Yang Cho
    Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, Republic of China
    Surg Neurol 62:378-85, discussion 385-6. 2004
    ..In this study, we try to use cages to replace plate function in multilevel cervical fusion...
  64. pmc Diet, ketones, and neurotrauma
    Mayumi Prins
    Department of Neurosurgery, UCLA David Geffen School of Medicine, Los Angeles, California 90095 7039, USA
    Epilepsia 49:111-3. 2008
    ..has been shown to be altered after head injury, and increasing cerebral metabolism of alternative substrates (ketones) has been shown to be neuroprotective in several models of traumatic brain injury...
  65. ncbi Thienyl and phenyl alpha-halomethyl ketones: new inhibitors of glycogen synthase kinase (GSK-3beta) from a library of compound searching
    Santiago Conde
    Instituto de Quimica Medica CSIC, Juan de la Cierva 2, 28006 Madrid, Spain
    J Med Chem 46:4631-3. 2003
    ..In this initial letter, some thienyl and phenyl alpha-halomethyl ketones are described as new non-ATP competitive inhibitors of GSK-3beta...
  66. ncbi Production and quantification of methyl ketones in wild tomato accessions
    G F Antonious
    Atwood Research Facility, Department of Plant and Soil Science, Kentucky State University, Frankfort 40601, USA
    J Environ Sci Health B 36:835-48. 2001
    Production of methyl ketones as naturally occurring insecticides from wild tomato accessions is explored in this study...
  67. ncbi Broad spectrum preclinical antitumor activity of eribulin (Halaven(R)): optimal effectiveness under intermittent dosing conditions
    Murray J Towle
    Discovery Biology, Oncology Product Creation Unit, Eisai Inc, Andover, MA, USA
    Anticancer Res 32:1611-9. 2012
    ..Here we extend those early studies by examining the effects of eribulin against a wider spectrum of human tumor xenografts in vivo, and by directly comparing the in vivo effectiveness of different dosing administration schedules...
  68. ncbi Synthesis of isoquinolines and heterocycle-fused pyridines via three-component cascade reaction of aryl ketones, hydroxylamine, and alkynes
    Liyao Zheng
    Department of Chemistry, Tsinghua University, Key Laboratory of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Beijing 100084, China
    J Org Chem 77:5794-800. 2012
    ..An efficient one-pot synthesis of isoquinolines and heterocycle-fused pyridines by three-component reaction of aryl ketones, hydroxylamine, and alkynes is developed...
  69. pmc Effects of a ketogenic diet during pregnancy on embryonic growth in the mouse
    Dafna Sussman
    Department of Medical Biophysics, Faculty of Medicine, University of Toronto, Toronto, Canada
    BMC Pregnancy Childbirth 13:109. 2013
    ..To date, no studies have thoroughly investigated the direct implications of a gestational ketogenic diet on embryonic development...
  70. ncbi Oxidative γ-addition of enals to trifluoromethyl ketones: enantioselectivity control via Lewis acid/N-heterocyclic carbene cooperative catalysis
    Junming Mo
    Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
    J Am Chem Soc 134:8810-3. 2012
    ..Enantioselectivity control involving the relatively remote enal γ-carbon was achieved via Lewis acid [Sc(OTf)(3) or combined Sc(OTf)(3)/Mg(OTf)(2)] and NHC cooperative catalysis...
  71. ncbi Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones
    Binoy Jose
    CREST Research Project, Japan Science and Technology Agency, Saitama 332 0012, Japan
    Bioorg Med Chem Lett 14:5343-6. 2004
    ..Evaluation by human HDAC inhibition assay and p21 promoter assay showed that these inhibitors are promising anticancer agents...
  72. ncbi Induction of morphological and biochemical apoptosis following prolonged mitotic blockage by halichondrin B macrocyclic ketone analog E7389
    Galina Kuznetsov
    Department of Candidate Assessment and In Vitro Technologies, Eisai Research Institute, Andover, Massachusetts 01810, USA
    Cancer Res 64:5760-6. 2004
    ..These results show that prolonged mitotic blockage by E7389 can lead to apoptotic cell death of human cancer cells in vitro and can provide a mechanistic basis for the significant in vivo anticancer efficacy of E7389...
  73. pmc Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems
    Wai Leung Ng
    Department of Molecular Biology, Princeton University, Princeton, NJ, USA
    Mol Microbiol 79:1407-17. 2011
    ..We isolated CqsS mutants in each species that display reversed specificity for ligands. Our analysis provides insight into how fidelity is maintained in signal transduction systems...
  74. pmc Engineering of Ralstonia eutropha H16 for autotrophic and heterotrophic production of methyl ketones
    Jana Müller
    Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
    Appl Environ Microbiol 79:4433-9. 2013
    ..We engineered R. eutropha for the production of fatty acid-derived, diesel-range methyl ketones. Modifications engineered in R...
  75. pmc Mechanistic insights into the gold-catalyzed cycloisomerization of bromoallenyl ketones: ligand-controlled regioselectivity
    Yuanzhi Xia
    Key Laboratory of Organic Synthesis of Jiangsu Province, Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215006, China
    J Am Chem Soc 130:6940-1. 2008
    ..Through computational and experimental studies, the mechanisms of gold-catalyzed cycloisomerization of bromoallenyl ketones in toluene have been elucidated...
  76. ncbi Modeling bovine serum albumin binding of flavor compounds (alcohols, aldehydes, esters, and ketones) as a function of molecular properties
    Y Tan
    Research, Development and Engineering Department, Philip Morris, Richmond, VA 23234, USA
    J Food Sci 73:S56-63. 2008
    ..Interactions between bovine serum albumin (BSA) and 4 classes of flavor compounds (alcohols, esters, aldehydes, and ketones) in aqueous solution were investigated using solid phase microextraction (SPME) of sample headspace and gas ..
  77. ncbi Isolation and antimicrobial evaluation of isomeric hydroxy ketones in leaf cuticular waxes of Annona squamosa
    K Shiva Shanker
    Lipid Science and Technology Division, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 007, India
    Phytochem Anal 18:7-12. 2007
    ..This isomeric mixture of hydroxy ketones constituted together 16.5% of the total cuticular waxes...
  78. ncbi Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory
    Evelin L Schaeffer
    Laboratory of Neuroscience LIM 27, Department and Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
    Psychopharmacology (Berl) 181:392-400. 2005
    ..In mice, intraperitoneal injections of a selective iPLA(2) inhibitor impaired spatial learning. Accordingly, reduced cPLA(2) and iPLA(2) activities were found in postmortem hippocampus of patients with Alzheimer's disease...
  79. pmc Composition of secondary alcohols, ketones, alkanediols, and ketols in Arabidopsis thaliana cuticular waxes
    Miao Wen
    Department of Chemistry, University of British Columbia, Vancouver, Canada
    J Exp Bot 60:1811-21. 2009
    ..4 microg cm(-2)) and C(28) to C(30) ketones (6.0 microg cm(-2)) dominated by C(29) homologues...
  80. pmc Test of the Binding Threshold Hypothesis for olfactory receptors: explanation of the differential binding of ketones to the mouse and human orthologs of olfactory receptor 912-93
    Patrick Hummel
    Materials and Process Simulation Center MC 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Protein Sci 14:703-10. 2005
    ..The olfactory receptor (OR) 912-93 is known experimentally to be activated by ketones in mouse, but is inactive to ketones in human, despite an amino acid sequence identity of approximately 66%...
  81. ncbi Chemoselective conjugate reduction of alpha,beta-unsaturated ketones catalyzed by rhodium amido complexes in aqueous media
    Xuefeng Li
    National Engineering Research Center of Chiral Drugs and Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China
    J Org Chem 75:2981-8. 2010
    ..could be switched from C=O to C=C bonds in the transfer hydrogenation of activated alpha,beta-unsaturated ketones. Now we have found that a variety of alpha,beta-unsaturated ketones, even without other electron-withdrawing ..
  82. ncbi Insights into the general and efficient cross McMurry reactions between ketones
    Xin Fang Duan
    Department of Chemistry, Beijing Normal University, Beijing, 100875, China
    J Org Chem 71:9873-6. 2006
    The selective cross McMurry couplings of diaryl or aryl ketones with various substituted ketones were achieved in 53-94% isolated yields...
  83. ncbi P[N(i-Bu)CH(2)CH(2)](3)N: nonionic Lewis base for promoting the room-temperature synthesis of α,β-unsaturated esters, fluorides, ketones, and nitriles using Wadsworth-Emmons phosphonates
    Venkat Reddy Chintareddy
    Department of Chemistry, Gilman Hall, Iowa State University, Ames, Iowa 50011, United States
    J Org Chem 75:7166-74. 2010
    ..esters, fluorides, and nitriles from a wide array of aromatic, aliphatic, heterocyclic, and cyclic aldehydes and ketones, using a range of Wadsworth-Emmons (WE) phosphonates...
  84. ncbi Catalytic asymmetric synthesis of quaternary α-hydroxy trifluoromethyl phosphonate via chiral aluminum(III) catalyzed hydrophosphonylation of trifluoromethyl ketones
    Xin Zhou
    Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, People s Republic of China
    Org Lett 12:4296-9. 2010
    ..complex has been first applied in the catalytic enantioselective hydrophosphonylation of trifluoromethyl ketones. The side reactions related to phospha-Brook rearrangement were completely avoided, and the corresponding ..
  85. ncbi Sc(OTf)3-catalyzed efficient synthesis of beta,beta-bis(indolyl) ketones by the double indolylation of acetic acid 2-methylene-3-oxobutyl ester
    Shengming Ma
    State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai, 200032, PR China
    Org Biomol Chem 3:1933-6. 2005
    ..acetic acid 2-methylene-3-oxo-butyl ester with differently substituted indoles readily afforded beta,beta-bis(indolyl) ketones. The reaction may proceed via a Sc(OTf)3-catalyzed SN2'-type substitution and subsequent conjugate addition.
  86. ncbi A sensitive and selective fluorescent thiol probe in water based on the conjugate 1,4-addition of thiols to alpha,beta-unsaturated ketones
    Weiying Lin
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China
    Chemistry 15:5096-103. 2009
    ..Probe 1 was constructed on the basis of the conjugate 1,4-addition of thiols to alpha,beta-unsaturated ketones. Notably, probe 1 has suitable water solubility, which allows the sensing assay to be performed in water...
  87. ncbi A high-performance liquid chromatography-tandem mass spectrometry method for the clinical combination study of carboplatin and anti-tumor agent eribulin mesylate (E7389) in human plasma
    Christopher Desjardins
    Drug Safety and Disposition, Eisai Research Institute, 4 Corporate Drive, Andover, MA 01810, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 875:373-82. 2008
    ..Both compounds were stable in human plasma (>or=80 days at -80 degrees C), at room temperature (>or=4h), following three freeze-thaw cycles and in 50/50 methanol/H(2)O (<4 degrees C for >or=252 days)...
  88. ncbi Non-fusion rates in anterior cervical discectomy and implantation of empty polyetheretherketone cages
    Ioannis Pechlivanis
    Department of Neurosurgery, University Hospital Mannheim, University of Heidelberg, Mannheim, Germany
    Spine (Phila Pa 1976) 36:15-20. 2011
    ..A prospective analysis...
  89. ncbi Silver-catalyzed asymmetric Sakurai-Hosomi allylation of ketones
    Manabu Wadamoto
    Department of Chemistry, The University of Chicago, Illinois 60637, USA
    J Am Chem Soc 127:14556-7. 2005
    ..R)-DIFLUORPHOS has been shown to be an effective catalyst for the asymmetric Sakurai-Hosomi allylation of simple ketones. A significaant improvement of the reactivity was observed by using THF as the solvent...
  90. ncbi Identification of modular chiral bisphosphines effective for Cu(i)-catalyzed asymmetric allylation and propargylation of ketones
    Shi Liang Shi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 132:6638-9. 2010
    ..Cu(I)-catalyzed asymmetric tetrasubstituted-carbon-forming reactions, namely, allylation and propargylation of ketones, were identified...
  91. pmc Discovery of adamantyl heterocyclic ketones as potent 11β-hydroxysteroid dehydrogenase type 1 inhibitors
    Xiangdong Su
    Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK
    ChemMedChem 6:1439-51. 2011
    ..A series of novel adamantyl heterocyclic ketones provides potent and selective inhibitors of human 11β-HSD1...
  92. ncbi Anterior cervical fusion using a polyetheretherketone cage containing a bovine xenograftp: three to five-year follow-up
    Chang Jung Chiang
    Department of Orthopedic Surgery, Taipei City Hospital, Taipei, Taiwan
    Spine (Phila Pa 1976) 33:2524-428. 2008
    ..Retrospective review of an anterior polyetheretherketone (PEEK) cage incorporated with a bovine xenograft to treat disorders of the cervical disc...
  93. pmc Osteoblasts exhibit a more differentiated phenotype and increased bone morphogenetic protein production on titanium alloy substrates than on poly-ether-ether-ketone
    Rene Olivares-Navarrete
    Wallace H Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Spine J 12:265-72. 2012
  94. ncbi Highly active, immobilized ruthenium catalysts for oxidation of alcohols to aldehydes and ketones. Preparation and use in both batch and flow systems
    Shu Kobayashi
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, The HFRE Division, ERATO, Japan Science and Technology Agency JST, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Am Chem Soc 127:9251-4. 2005 immobilized ruthenium catalyst, which can be successfully used in oxidation of alcohols to aldehydes and ketones, has been developed...
  95. ncbi Chemical images of marine bio-active compounds by surface enhanced Raman spectroscopy and transposed orthogonal partial least squares (T-OPLS)
    Aamer Abbas
    Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden
    Anal Chim Acta 737:37-44. 2012
    ..In this paper we show the possibility to retrieve specific spectral information with a low magnitude in a complex matrix...
  96. ncbi Odor-active compounds of Iberian hams with different aroma characteristics
    Ana I Carrapiso
    Laboratory of Food Technology, University of Extremadura, 10071 Caceres, Spain
    J Agric Food Chem 50:6453-8. 2002
    ..Otherwise, the largest scores for moldy aroma in long-Montanera hams matched with the largest detection frequency of 1-octen-3-one and 1-octen-3-ol in this group...
  97. ncbi Design and synthesis of modular oxazoline ligands for the enantioselective chromium-catalyzed addition of allyl bromide to ketones
    Jeremie J Miller
    Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, USA
    J Am Chem Soc 129:2752-3. 2007
  98. ncbi Mild and general zinc-alkoxide-catalyzed allylations of ketones with allyl pinacol boronates
    Keith R Fandrick
    Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc, 900 Ridgebury Road, P O Box 368, Ridgefield, Connecticut 06877 0368, USA
    Org Lett 12:3748-51. 2010
    A general and efficient zinc-alkoxide-catalyzed allylation of a diverse array of ketones with allyl boronates is presented. The methodology is effective with 2 mol % of catalyst and with relatively short reaction times...
  99. pmc Synthesis of cyclic enones via direct palladium-catalyzed aerobic dehydrogenation of ketones
    Tianning Diao
    Department of Chemistry, University of Wisconsin Madison, 1101 University Avenue, Madison, Wisconsin 53706, USA
    J Am Chem Soc 133:14566-9. 2011
    ..application of Pd(DMSO)(2)(TFA)(2) as a catalyst for direct dehydrogenation of cyclohexanones and other cyclic ketones to the corresponding enones, using O(2) as the oxidant...
  100. pmc Optimization of culture conditions to produce high yields of active Acetobacter sp. CCTCC M209061 cells for anti-Prelog reduction of prochiral ketones
    Xiao hong Chen
    Lab of Applied Biocatalysis, South China University of Technology, Guangzhou, 510640, China
    BMC Biotechnol 11:110. 2011
    ..CCTCC M209061 showed exclusive anti-Prelog stereoselectivity for the reduction of prochiral ketones, but the low biomass has limited its commercialization and industrial applications...
  101. ncbi Chiral primary-tertiary diamine catalysts derived from natural amino acids for syn-aldol reactions of hydroxy ketones
    Jiuyuan Li
    Beijing National Laboratory for Molecule Sciences, Center for Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190 China
    J Org Chem 74:1747-50. 2009
    ..Application of these new chiral catalysts in direct aldol reactions of alpha-hydroxyketones showed very good catalytic activity (up to 97% yield) and high syn selectivity (up to syn/ anti = 30:1, 99% ee)...

Research Grants63

  1. Energy Balance During Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2010
    ..Although glucose is considered the primary fuel for brain, ketones supplement brain metabolism, especially under conditions of glucose sparing, such as fasting, starvation or high ..
    Oscar A Bizzozero; Fiscal Year: 2012
    ..A major consequence of ROS accumulation is the non-enzymatic introduction of aldehydes or ketones into specific amino acid residues of proteins (i.e. carbonylation)...
  3. Angiogenic Response to Hypoxia and Ketosis in Rat Brain
    JOSEPH CHARLES LAMANNA; Fiscal Year: 2012
    ..The increased blood ketones were accompanied by up-regulation of the primary substrate transporters for glucose (GLUT1) and ketones (..
  4. Using Ketogenic Diets to Enhance Radio-Chemo-Therapy Response: A Phase I Trial
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2012
    ..Furthermore, subject blood will be analyzed for evidence of increases in parameters indicative of ketosis (serum ketones and blood glucose) as well as parameters of oxidative stress (lipid peroxidation, DNA oxidation, and protein ..
  5. The Role of Mitochondrial Dysfunction in Non-Alcoholic Fatty Liver Disease
    Jeffrey D Browning; Fiscal Year: 2013
    ..Attenuation of hepatic 2-oxidation may be associated with decreased export of ketones to the periphery in favor of local energy generation to support cellular processes in the hepatocyte...
  6. Differential Redox &Electrophilic Toxicities of Modified Tobacco Products
    Norbert Staimer; Fiscal Year: 2013
    ..Our overall objective is to characterize the toxic effects of electrophilic and/or redox-active conjugated ketones from different cigarette brands marketed as being modified for harm reduction...
  7. The distinct roles of AMPK in neurons and astrocytes following stroke
    Jun Li; Fiscal Year: 2013
    ..In contrast, astrocytes can perform glycolysis, oxidize fatty acids to form ketones, and store some glycogen providing an energy supply for ischemic neurons...
  8. A Cell Biological Approach to Hepatic Lipid Metabolism
    Shadab A Siddiqi; Fiscal Year: 2012
    ..hepatic lipotoxicity, the liver efficiently converts FFA to triacylglycerol (TAG) for storage, oxidizes them to ketones, or exports them as very-low density lipoproteins (VLDLs)...
  9. Enzymes of the Vinca Alkaloids
    Aimee Usera; Fiscal Year: 2010
    ..The tags will include radiolabels as well as alkynes and ketones, capable of incorporating biotin labels through click chemistry and oxime formation, respectively...
  10. Targeting Histone Deacetylases with Small Moleule Inhibitors in Ovarian Cancer
    Dineo Khabele; Fiscal Year: 2013
    ..BRD7914 exhibits potent HDAC3 inhibitory binding and is derived from a brand new class of electrophilic ketones. These results are in line with emerging evidence that HDAC3 inhibition is a key contributor to chromatin ..
  11. Cognitive Behavioral Intervention in Diabetes Self-Mgt.
    Jillian Inouye; Fiscal Year: 2009 relationship to meals, blood testing is often required two to three times a day as well as urine testing for ketones when glucose tests are high...
  12. Enhancement of Cancer Therapy Using Ketogenic Diets
    DOUGLAS ROBERT SPITZ; Fiscal Year: 2010 applicant): Ketogenic diets, which are low in protein and carbohydrates and high in fats, result in elevated ketones (2-hydroxybuturate and acetoacetate;precursors to Acetyl-CoA) forcing cells to rely more heavily on mitochondrial ..
  13. Enhanced Recovery of Pharmaceutical Solvent driven by EPA Initiative
    JOHN J BOWSER; Fiscal Year: 2013
    ..Therefore, from a chemical stability standpoint, it can be operated with alcohols, organic acids, ketones, amines and aprotic solvents, to name a few...
  14. Ketosis, Vascular Inflammation and Its Therapy in Type 1 Diabetic Patients
    Sushil K Jain; Fiscal Year: 2010
    ..In vitro, monocytes isolated from P or Cr3+ supplemented patients or HAEC will be cultured with ketones to examine their direct effect on markers of vascular inflammation and gene expression related to cytokine ..
  15. The Effects of Ketogenic Diets on Inflammation and Chronic Pain
    DAVID NATHANIEL RUSKIN; Fiscal Year: 2010
    ..The carbohydrate restriction decreases the metabolism of glucose and increases the metabolism of ketones. To date, the ketogenic diet has shown proven clinical efficacy in epilepsy and demonstrated basic research ..
  16. Role of Acetate in Heavy Drinking
    Graeme F Mason; Fiscal Year: 2010
    ..Therefore, we hypothesize that through repeated exposure to elevated acetate, ketones, lactate, and hypoglycemia, heavy drinkers who experience repeated episodes of hypoglycemia are more able to ..
    Peter A Crawford; Fiscal Year: 2013
    ..g., Atkins) diets. Ketones are known to be metabolically important for two reasons: first, their accumulation in blood can promote ..
  18. Asymmetric Lewis Base Catalysis in Main Group Chemistry
    Scott Eric Denmark; Fiscal Year: 2013 of enantiomerically enriched ?-aryl, ?-alkenyl, ?-alkynyl, and also potentially ?-aryl substituted ketones and esters...
  19. Modulation of neural function in energy failure
    JUAN MANUEL PASCUAL; Fiscal Year: 2013
    ..The proposal also includes the therapeutic consideration that even-carbon ketones, generated from common dietary fats or a ketogenic diet, can fuel the TCA cycle and ameliorate seizures in G1D, ..
  20. A Breath-based Naltrexone Adherence Tool to Manage Narcotic-addicted HIV patients
    DONN MICHAEL DENNIS; Fiscal Year: 2012 alcohol dehydrogenase (ADH is not subject to genetic polymorphisms, unlike the isoform) to generate volatile ketones (e.g...
    GERALD KOSER; Fiscal Year: 1990
    ..The functionalization of ketones and beta-dicarbonyl compounds, silyl enol ethers, silyl ketene acetals, alkenes, conjugated dienes, alkynes and ..
  22. Enantioselective Synthesis of Phosphinate Derivatives
    John Cong Gui Zhao; Fiscal Year: 2012
    ..aldol (or Mannich) reaction of 1-ketophosphinic acid derivatives (or 1-iminophosphinic acid derivatives) and ketones/enolizable aldehydes for the enantioselective synthesis of 1-hydroxy (or amino) phosphinic acid derivatives...
  23. Pilot Scale Libraries Inspired by Natural Products
    JEFFREY AUBE; Fiscal Year: 2012
    ..are (1) alkaloid-like libraries derived from Lewis acid promoted reactions of alkyl azides that afford complex ketones that are subsequently converted to carbamates, amines, indoles, or other heterocyclic products, (2) libraries ..
  24. TBI-Induced Cerebral Metabolic Depression and Recovery
    David A Hovda; Fiscal Year: 2013
    ..Transporters for the fuels glucose, lactate and ketones will be measured in terms of their expression and function...
  25. Microneedle arrays for non-invasive continuous multianalyte sensing in diabetes
    Joshua Ray Windmiller; Fiscal Year: 2013
    ..Blood catecholamines and ketones are some examples of neurotransmitters and metabolites that can augment standard blood glucose measurements, ..
  26. Palladium-Catalyzed Aerobic Dehydrogenation of Carbon-Carbon Bonds
    Shannon S Stahl; Fiscal Year: 2013
    ..cyclohexanones and cyclohexenones to prepare a variety of substituted phenol derivatives, (2) dehydrogenation of ketones and other carbonyl compounds to prepare versatile 1,2-unsaturated carbonyl compounds, (3) dehydrogenation of ..
  27. Developing the Synthetic Utility of the Copper-Catalyzed Diboration of Aldehydes
    Timothy B Clark; Fiscal Year: 2010
    ..involves the development of synthetic methods that utilizes the copper-catalyzed diboration of aldehydes, ketones, and imines...
    Andrew Streitwieser; Fiscal Year: 1999 additional enolates of interest and to measure the reaction kinetics of their Aldol additions to aldehydes and ketones and of Michael addition reactions with unsaturated carbonyl compounds...
  29. Synthesis of Chiral Organofluorines via Catalytic Asymmetric C-C Bond Formation w
    Christian Wolf; Fiscal Year: 2013
    ..our laboratories we have found an entry towards a practical catalytic asymmetric alkynylation of trifluoromethyl ketones. Further ligand and method development will go hand-in-hand with mechanistic studies and screening of promising ..
  30. Stereochemistry of Elimination and Proton Transfer
    JERRY MOHRIG; Fiscal Year: 2002
    ..elimination reactions involving n-substituted esters and thioesters of butyric acid and the related aldehydes and ketones. The objective of the research program is a comprehensive understanding of the stereochemical consequences of the ..
  31. Rhodium-Catalyzed 1,2-Addition of Pinacolboronic Esters into Ketones
    GARY MICHAEL GALLEGO; Fiscal Year: 2013
    ..We wish to extend the scope of this reaction to include additions of pinacolboronic esters into unactivated ketones using Rh(I) catalysis...
  32. Enantioselective Thiourea-Catalyzed Syntheses of beta-Lactones and beta-Lactams
    PAMELA MICHELE TADROSS; Fiscal Year: 2013
    ..the thiourea catalyst will mediate the formal [2+2] cycloaddition reaction between ketenes and aldehydes, ketones, and imines. By this process, a diverse array of products can be generated that bear vicinal stereogenic carbons...
  33. Acetone metabolism in Helicobacter pylori
    Timothy Hoover; Fiscal Year: 2004
    ..b>Ketones are always present in the blood, with up to 185 grams of ketone bodies produced per day by the liver of a healthy ..
    PATSY BRANNON; Fiscal Year: 1990
    ..The effects of fatty acids and their interaction with secretin and ketones in the regulation of both enzymes will be examined in cultured cells...
  35. Palladacycle-Catalyzed Tandem Double Addition Reactions for Organic Synthesis
    Qiao Sheng Hu; Fiscal Year: 2010
    ..1,2-ethenediboronic acid esters with 1,2-unsaturated carbonyl-containing compounds, 1,n-alkanedials and divinyl ketones will be investigated...
  36. Refining &Implementing Supramolecular Methods for HTS of EE &Concentration
    Eric V Anslyn; Fiscal Year: 2013
    ..a few assays for chiral functional groups that are almost operational (primary amines, carboxylic acids, and ketones), and we will devise an assay for chiral secondary alcohols...
  37. Catalytic Asymmetric Hydrogenation
    Xumu Zhang; Fiscal Year: 2007
    ..The P.I. has developed a chiral ligand toolbox for asymmetric hydrogenation of ketones, alkenes, imines and aromatic compounds...
    Patrick J Walsh; Fiscal Year: 2010
    ..We have developed one-pot synthesis of a-hydroxy ketones, allylic alcohols, and substituted cyclopropanes from a versatile 1-alkenyl-1,1-bimetallic intermediate...
    ADNAN ELFARRA; Fiscal Year: 1992
    ..investigate the possibility that reactive oxidative metabolitese other than the epoxides (reactive aldehydes and ketones) may be formed. 3) To determine the role of glutathione in the metabolism and toxicity of conjugated dienes...
    BARRY SNIDER; Fiscal Year: 2000
    ..Preliminary results suggest that high yields are obtained from ketones in which enolization is possible or favored to only one side of the ketone and when the product can't enolize ..
    Max Deinzer; Fiscal Year: 2002
    ..of electrophilic compounds including organophosphates, sulfonamides, dinitro [2,2]para- cyclophane, aliphatic ketones, haloethenes, vinyl chloride and chloroacetaldehyde will be investigated...
  42. Synthesis of Potentially Bioactive Peroxides by Electrophilic Activation
    SHELLI WAETZIG; Fiscal Year: 2009
    ..The intramolecular cyclization of aldehydes and ketones onto activated alkynes will be optimized in the presence of peroxide nucleophiles...
  43. The role of ketones in the anticonvulsant mechanism of the ketogenic diet
    Karin Borges; Fiscal Year: 2009
    ..One main characteristic of the diet is that it increases the blood levels of ketones, including D-[unreadable]-hydroxybutyrate (D-BHB), acetoacetate, its degradation product acetone, and potentially ..
  44. Catalytic hydroacylation: Transforming C-H bonds into biorelevant esters and keto
    VY M DONG; Fiscal Year: 2013 an ideal and powerful strategy for making carbonyl-containing compounds, including both esters and ketones. This innovative approach will lead to step- and atom-economical, sustainable, and stereoselective methods that ..
    Brice Bosnich; Fiscal Year: 1991
    ..we propose to investigate the classical Diels-Alder partners, alpha-beta- unsaturated esters, aldehydes and ketones with butadienes and cyclopentadiene. The emphasis is on the nature of the catalysis...
  46. LC/MS of Large Atherogenic Lipid Oxidation Products
    WILLIAM BYRDWELL; Fiscal Year: 2003
    ..oxidation products that contain fatty acids with multiple functional groups, such as hydroperoxides, epoxides, ketones and alcohols. Fatty acid oxidation products have been shown to represent a significant atherosclerotic risk...
  47. Synthetic Utility of Silylene Transfer to Divinylketones
    CHRISTIAN VENTOCILLA; Fiscal Year: 2009
    ..Silver-catalyzed silylene transfer to divinyl ketones followed by treatment with a dienophile allows for the rapid construction of highly functionalized cyclohexenes ..
  48. Human Brain Metabolism in Ketosis
    Jullie Pan; Fiscal Year: 2004
    ..However, specifically how the human brain uses ketones is not well defined...
    FREDERICK SIEBER; Fiscal Year: 1993
    ..This proposal examines the effects of blood glucose on cerebral blood flow (CBF) and metabolism (M) of O2, glucose, ketones, lactate and pyruvate, emphasizing the changes with occur with acute hypoglycemia (HG) and with chronic ..
  50. Optimizing Escherichia coli for Carbonyl Reductions
    JAMES ROZZELL; Fiscal Year: 2007
    ..alcohols are ubiquitous intermediates in the synthesis of chiral drugs, and the stereoselective reduction of ketones is therefore a reaction of central importance in the preparation of chiral pharmaeutical products...
  51. New Transition Metal Catalysts for Organic Reactions
    F D Toste; Fiscal Year: 2010
    ..complexes can be employed as catalysts for chemoselective and enantioselective hydrosilylation of aldehydes, ketones and imines. This represents a reversal in the traditional role of this catalysts as oxidizing agents...
  52. Highly Active Palladium Catalysts for Organic Synthesis
    Qiao Sheng Hu; Fiscal Year: 2004
    ..coupling, the Stille coupling, the Heck coupling, the Sonogashira coupling, the arylation of aryl halides with ketones and esters, and the amination of aryl halides with amines, etc...
  53. Symposium on Aldo-Keto Reductases & Toxicant Metabolism
    TREVOR PENNING; Fiscal Year: 2002
    ..and the metabolism of chemical carcinogens including aflatoxin dialdehyde, nicotine derived nitrosamino-ketones and polycyclic aromatic trans-dihydrodiols...
    Barbara Imperiali; Fiscal Year: 1999
    ..acid decarboxylase and (3) A nicotinamide dependent system for the stereospecific reduction of unactivated ketones that employs divalent zinc for carbonyl activation...
  55. Novel Multiple-Component X-C/C-C Formation Reactions
    Guigen Li; Fiscal Year: 2003
    ..reactions will be carried out by 1,4-robust activation and 1,2-tandem functionalization of alpha,beta-alkylenic ketones. New chiral phosphoramides and polymer beads-attached chiral phosphoramides are designed and will be synthesized ..
  56. MBRS/SCORE Program at Fisk University
    WARREN COLLINS; Fiscal Year: 2004
    ..use of Lithium dialkylamides and their mixed aggregates to serve as intermediates in the generation of aldehydes, ketones, and esters, a major organic problem in drug synthesis, and (6) to determine if the difference in Raman spectra ..
  57. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
    JEFFREY AUBE; Fiscal Year: 1992
    ..Finally, a novel scheme to control regioselectivity on nearly- symmetrical double bonds or epoxides will be presented...
  59. Novel Enzymatic Reductive Amination
    JAMES ROZZELL; Fiscal Year: 2002
    ..the first group of amine dehydrogenase enzymes evolved to catalyze the stereoselective reductive amination of ketones to the corresponding chiral amines...
  60. Adjuvant Therapy for Vascular Inflammation in Diabetes
    Sushil Jain; Fiscal Year: 2006
    ..studies also show that chromium (Cr3+) and vitamin E (VE) inhibit the secretion of TNF-alpha and IL-6 caused by ketones (AA) and high glucose (HG) in a cell culture model using U937 monocytes and fresh peripheral blood mononuclear ..
    RICHARD SCHLESSINGER; Fiscal Year: 1990
    ..of learning new chemistry, concerns the application of some organotin reagents to reaction with sugar-derived ketones. These reactions yield stereochemistry that is the reverse of the more usual stereochemistry observed with ..
  62. Treatment strategies in a rat model of cardiac arrest
    Joseph LaManna; Fiscal Year: 2005
    ..propose to investigate new treatment strategies aimed at using alternate energy substrates such as, pyruvate and ketones in combination with antioxidant type drugs, such as, melatonin, N-t-Butyl-a-Phenyl-nitrone, adenosine and ..
    Michael McDaniel; Fiscal Year: 2007
    ..Preliminary data demonstrate that free fatty acids (FFAs), ketones and glucose activate mTOR and enhance DNA synthesis as a prerequisite for (3-cells to enter the cell cycle and ..