imides

Summary

Top Publications

  1. ncbi Carboxy-terminal sequencing: formation and hydrolysis of C-terminal peptidylthiohydantoins
    J M Bailey
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Biochemistry 29:3145-56. 1990
  2. ncbi Synergistic effects of amides from two piper species on generalist and specialist herbivores
    Lora A Richards
    Department of Biology, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA
    J Chem Ecol 36:1105-13. 2010
  3. ncbi Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles
    Elisabeth Conchon
    Laboratoire SEESIB, Universite Blaise Pascal, UMR 6504 du CNRS, 63177 Aubiere, France
    Bioorg Med Chem 16:4419-30. 2008
  4. ncbi Synthesis and theoretical calculations of 5-aminosalicylic acid derivatives as potential analgesic agents
    Correa Basurto José
    Sección de Estudios de Posgrado e Investigación, Departamento de Bioquimica, Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron, Mexico City, Mexico
    Med Chem 4:25-9. 2008
  5. ncbi An investigation into the allylic imidate rearrangement of trichloroacetimidates catalysed by cobalt oxazoline palladacycles
    Hiroshi Nomura
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Chemistry 13:10216-24. 2007
  6. pmc Structure-activity relationship studies of small-molecule inhibitors of Wnt response
    Jianming Lu
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Bioorg Med Chem Lett 19:3825-7. 2009
  7. ncbi Perylene imides for organic photovoltaics: yesterday, today, and tomorrow
    Chen Li
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128 Mainz, Germany
    Adv Mater 24:613-36. 2012
  8. ncbi Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent
    Vincenzo Tumiatti
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 52:7873-7. 2009
  9. ncbi Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study
    Alaa A M Abdel-Aziz
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Eur J Med Chem 46:1648-55. 2011
  10. ncbi Highly enantioselective, catalytic conjugate addition of cyanide to alpha,beta-unsaturated imides
    Glenn M Sammis
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    J Am Chem Soc 125:4442-3. 2003

Research Grants

Detail Information

Publications281 found, 100 shown here

  1. ncbi Carboxy-terminal sequencing: formation and hydrolysis of C-terminal peptidylthiohydantoins
    J M Bailey
    Division of Immunology, Beckman Research Institute of the City of Hope, Duarte, California 91010
    Biochemistry 29:3145-56. 1990
    ..Asparagine was found to form cyclic imides (64%) at the penultimate position (C-2) during hydrolysis of the peptidylthiohydantoins by 2% aqueous ..
  2. ncbi Synergistic effects of amides from two piper species on generalist and specialist herbivores
    Lora A Richards
    Department of Biology, University of Nevada, Reno, 1664 N Virginia Street, Reno, NV 89557, USA
    J Chem Ecol 36:1105-13. 2010
    ..In this study, we performed feeding experiments to examine the synergistic effects of imides and amides (hereafter "amides") from Piper cenocladum and P...
  3. ncbi Synthesis, checkpoint kinase 1 inhibitory properties and in vitro antiproliferative activities of new pyrrolocarbazoles
    Elisabeth Conchon
    Laboratoire SEESIB, Universite Blaise Pascal, UMR 6504 du CNRS, 63177 Aubiere, France
    Bioorg Med Chem 16:4419-30. 2008
    ....
  4. ncbi Synthesis and theoretical calculations of 5-aminosalicylic acid derivatives as potential analgesic agents
    Correa Basurto José
    Sección de Estudios de Posgrado e Investigación, Departamento de Bioquimica, Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron, Mexico City, Mexico
    Med Chem 4:25-9. 2008
    ..All compounds showed analgesic activities from 0.1 mg/Kg to 16 mg/Kg in the mouse model. The imides showed more affinity by COX enzymes and their Log Ps were the highest...
  5. ncbi An investigation into the allylic imidate rearrangement of trichloroacetimidates catalysed by cobalt oxazoline palladacycles
    Hiroshi Nomura
    School of Biological and Chemical Sciences, Queen Mary, University of London, Mile End Road, London, E1 4NS, UK
    Chemistry 13:10216-24. 2007
    ..Catalysis with COP-OAc displayed a small positive non-linear effect. The factors responsible for the activity of COP-X are discussed...
  6. pmc Structure-activity relationship studies of small-molecule inhibitors of Wnt response
    Jianming Lu
    Department of Biochemistry, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Bioorg Med Chem Lett 19:3825-7. 2009
    ..Herein, we present the results of structure-activity relationship studies of these compounds...
  7. ncbi Perylene imides for organic photovoltaics: yesterday, today, and tomorrow
    Chen Li
    Max Planck Institute for Polymer Research, Ackermannweg 10, D 55128 Mainz, Germany
    Adv Mater 24:613-36. 2012
    Perylene imides have been an object of research for 100 years and their derivatives are key n-type semiconductors in the field of organic electronics...
  8. ncbi Design, synthesis, and biological evaluation of substituted naphthalene imides and diimides as anticancer agent
    Vincenzo Tumiatti
    Department of Pharmaceutical Sciences, Alma Mater Studiorum, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy
    J Med Chem 52:7873-7. 2009
    ..Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation...
  9. ncbi Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study
    Alaa A M Abdel-Aziz
    Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
    Eur J Med Chem 46:1648-55. 2011
    A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activities using carrageenan-induced rat paw edema model...
  10. ncbi Highly enantioselective, catalytic conjugate addition of cyanide to alpha,beta-unsaturated imides
    Glenn M Sammis
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    J Am Chem Soc 125:4442-3. 2003
    Salen)Al-Cl complex 1a catalyzes the asymmetric conjugate addition of hydrogen cyanide to alpha,beta-unsaturated imides in high yields and enantioselectivities...
  11. ncbi Changing DNA grooves--a 1,4,5,8-naphthalene tetracarboxylic diimide bis-intercalator with the linker (beta-Ala)(3)-Lys in the minor groove
    Vladimir Guelev
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78722, USA
    J Am Chem Soc 124:2864-5. 2002
    ....
  12. ncbi Peptide bis-intercalator binds DNA via threading mode with sequence specific contacts in the major groove
    V Guelev
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 78722, USA
    Chem Biol 8:415-25. 2001
    ....
  13. ncbi Enantioselective Michael additions to alpha,beta-unsaturated imides catalyzed by a Salen-Al complex
    Mark S Taylor
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 125:11204-5. 2003
    ..of di- and trisubstituted nitriles to a wide range of acyclic alkyl- and aryl-substituted alpha,beta-unsaturated imides. This new methodology provides access to multifunctional compounds that previously have not been readily ..
  14. ncbi Synthesis and hydrogenation of bis(imino)pyridine iron imides
    Suzanne C Bart
    Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853, USA
    J Am Chem Soc 128:5302-3. 2006
    ..Catalytic aryl azide hydrogenation has also been achieved, and the observed relative rates are consistent with N-H bond formation as the rate-determining step in aniline formation...
  15. ncbi Base-mediated conversion of hydrazine to diazene and dinitrogen at an iron center
    Leslie D Field
    School of Chemistry, University of New South Wales, New South Wales 2052, Australia
    Inorg Chem 48:5-7. 2009
    ..This reaction is reversed by the treatment of the diazene complex with a mild acid, while treatment of the hydrazine complex with a mixture of KOBu(t) and Bu(t)Li afforded the dinitrogen complex [Fe(N(2))(dmpe)(2)]...
  16. pmc Diazene (HN=NH) is a substrate for nitrogenase: insights into the pathway of N2 reduction
    Brett M Barney
    Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84322, USA
    Biochemistry 46:6784-94. 2007
    ..Implications of these findings for the mechanism of N2 reduction by nitrogenase are discussed...
  17. ncbi An octakis-intercalating molecule
    M M Murr
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, TX 78712, USA
    Bioorg Med Chem 9:1141-8. 2001
    ..Our so-called "octamer" represents, to the best of our knowledge, the first intercalator that binds as an octakis-intercalator, capable of spanning at least 16 base pairs of DNA...
  18. pmc A methyldiazene (HN=N-CH3)-derived species bound to the nitrogenase active-site FeMo cofactor: Implications for mechanism
    Brett M Barney
    Department of Chemistry and Biochemistry, Utah State University, Logan, UT 84322, USA
    Proc Natl Acad Sci U S A 103:17113-8. 2006
    ..Although current information does not rule out the d-mechanism, the a-mechanism is more attractive because proton delivery to substrate has been specifically compromised in alpha-195Gln-substituted MoFe protein...
  19. ncbi Alpha,beta-unsaturated beta-silyl imide substrates for catalytic, enantioselective conjugate additions: a total synthesis of (+)-lactacystin and the discovery of a new proteasome inhibitor
    Emily P Balskus
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    J Am Chem Soc 128:6810-2. 2006
    ..the highly enantioselective conjugate addition of carbon-centered nucleophiles to alpha,beta-unsaturated silyl imides. Allyldimethylsilane-substituted imide 4 was identified as an optimal substrate, undergoing addition reactions ..
  20. ncbi Ultrafast spectroscopy of the solvent dependence of electron transfer in a perylenebisimide dimer
    Michael W Holman
    Department of Chemistry, Columbia University, New York, New York 10027, USA
    J Phys Chem A 109:8548-52. 2005
    ..Good quantitative agreement with rates derived from fluorescence quantum yield and time-resolved fluorescence measurements was found for forward electron transfer and charge recombination rates...
  21. ncbi A practical ruthenium-catalyzed cleavage of the allyl protecting group in amides, lactams, imides, and congeners
    Benito Alcaide
    Departamento de Quimica Organica I, Facultad de Quimica, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Chemistry 12:2874-9. 2006
    ..The first examples accounting for the ruthenium-catalyzed deallylation of amides, lactams, imides, pyrazolidones, hydantoins, and oxazolidinones have been achieved by the sequential use of Grubbs carbene (..
  22. ncbi Magnesium bistrifluoromethanesulfonimide as a new and efficient acylation catalyst
    Asit K Chakraborti
    Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research NIPER, Sector 67, S A S Nagar 160 062, Punjab, India
    J Org Chem 71:5785-8. 2006
    ..Chemoselective acetylation, pivalation, and benzoylation took place with acid-sensitive alcohols without any competitive dehydration/rearrangement...
  23. ncbi Light-harvesting metallosupramolecular squares composed of perylene bisimide walls and fluorescent antenna dyes
    Chang Cheng You
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 12:7510-9. 2006
    ..05). Thus, this multichromophore square assembly with aminonaphthalimide antenna dyes is an artificial model for the cyclic light-harvesting complexes in purple bacteria...
  24. ncbi Self-organized perylene diimide nanofibers
    Ping Yan
    Department of Chemistry, Columbia University, 3000 Broadway, New York, New York 10027, USA
    J Phys Chem B 109:724-30. 2005
    ..The delocalization along these nanofibers and the ability to study the electronic structure using fluorescence make them potentially useful in nanoscale devices, such as field effect transistors and photoconductors...
  25. ncbi Synthesis, hydrolyses and dermal delivery of N-alkyl-N-alkyloxycarbonylaminomethyl (NANAOCAM) derivatives of phenol, imide and thiol containing drugs
    Susruta Majumdar
    Department of Medicinal Chemistry, University of Florida, Gainesville, 32610, USA
    Bioorg Med Chem Lett 16:3590-4. 2006
    ..NANAOCAM promoieties can act as novel prodrug derivatives of phenol, imide and thiol containing drugs for enhancing topical absorption...
  26. ncbi Hydrolysis of plasmid DNA and RNA by amino alkyl naphthalimide as metal-free artificial nuclease
    Qing Yang
    Department of Bioscience and Biotechnology, Dalian University of Technology, Dalian 116024, China
    Bioorg Med Chem Lett 16:803-6. 2006
    ..4 can hydrolyze 4 kb plasmid DNA into 2 kb fragments with GC and GG selectivity, which represents a novel example of sequence- or site-selective metal-free DNA artificial nuclease. Results also show it could hydrolyze RNA efficiently...
  27. ncbi Towards highly fluorescent and water-soluble perylene dyes
    Christopher Kohl
    Max Planck Institut fur Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany
    Chemistry 10:5297-310. 2004
    ....
  28. ncbi Recognition of polyimide sequence information by a molecular tweezer
    Howard M Colquhoun
    School of Chemistry, University of Reading, Whiteknights, Reading, RG6 6AD, UK
    Angew Chem Int Ed Engl 43:5040-5. 2004
  29. ncbi Perylene bisimide based macrocycles: effective probes for the assessment of conformational effects on optical properties
    Peter Osswald
    Institut fur Organische Chemie, Bayerische Julius Maximilians Universität Würzburg, Am Hubland, 97074 Wurzburg, Germany
    Angew Chem Int Ed Engl 44:250-3. 2004
  30. ncbi Photophysical study of photoinduced electron transfer in a bis-thiophene substituted peryleneimide
    Eduard Fron
    Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200 F, 3001, Heverlee, Belgium
    Photochem Photobiol Sci 4:61-8. 2005
    ..This ion-pair state then decays with two time constants of 1400 and 820 ps, probably corresponding to different conformations of the thiophene rings...
  31. ncbi Altering the folding patterns of naphthyl trimers
    Gregory J Gabriel
    Department of Chemistry and Biochemistry, The University of Texas at Austin, Austin, Texas 78712, USA
    J Am Chem Soc 127:2637-40. 2005
    ..This study illustrates the designability of folding naphthyl oligomers and encourages the use of directed aromatic interactions to construct larger and more complex assemblies in water...
  32. ncbi Novel heterocyclic family of phenyl naphthothiazole carboxamides derived from naphthalimides: synthesis, antitumor evaluation, and DNA photocleavage
    Zhigang Li
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
    Bioorg Med Chem 13:3149-55. 2005
    ..5 microM and total cleavage from form I to 100% form II at 50 microM. The photocleaving mechanism was changed with the modification to be via superoxide anion and radical...
  33. ncbi Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase
    Vincent M Loh
    KuDOS Horsham Ltd, 26 Foundry Lane, Horsham, West Sussex RH13 5PX, UK
    Bioorg Med Chem Lett 15:2235-8. 2005
    ....
  34. ncbi Enantioselective Michael addition to alpha,beta-unsaturated imides catalyzed by a bifunctional organocatalyst
    Yasutaka Hoashi
    Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo ku, Kyoto 606 8501, Japan
    Angew Chem Int Ed Engl 44:4032-5. 2005
  35. ncbi Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: effects of intercalation, side chains, and substituent groups
    Zhigang Li
    State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China
    Bioorg Med Chem 13:4864-70. 2005
    ..A1, the most active compound against P388, was about 6-fold more cytotoxic than amonafide. C2, the most efficient DNA intercalator, showed the strongest DNA photocleaving activity via superoxide anion produced under UV light at 360 nm...
  36. ncbi Recent advances in catalytic, enantioselective alpha aminations and alpha oxygenations of carbonyl compounds
    Jacob M Janey
    Department of Process Research, Merck Research Laboratories, Merck and Co, Inc P O Box 2000, Rahway, NJ 07065, USA
    Angew Chem Int Ed Engl 44:4292-300. 2005
    ..This Minireview provides a synopsis of this ever-growing field and highlights some of the challenges that still remain...
  37. ncbi Paradoxical solvent effects on the absorption and emission spectra of amino-substituted perylene monoimides
    Peter D Zoon
    van t Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
    Chemphyschem 6:1574-80. 2005
    ..The latter shows the conventional solvatochromic behavior of a push-pull substituted conjugated system, that is, minor shifts in absorption and a larger change in the emission energy with solvent polarity...
  38. ncbi Design, synthesis, and evaluation of cyclic amide/imide-bearing hydroxamic acid derivatives as class-selective histone deacetylase (HDAC) inhibitors
    Chihiro Shinji
    Institute of Molecular and Cellular Biosciences, The University of Tokyo, Yayoi, Bunkyo ku, Tokyo 113 0032, Japan
    Bioorg Med Chem 14:7625-51. 2006
    ....
  39. ncbi Synthesis of a non-cationic, water-soluble perylenetetracarboxylic diimide and its interactions with G-quadruplex-forming DNA
    Ramakrishna Samudrala
    Department of Chemistry and Biochemistry, Box 1848, University of Mississippi University, MS 38677, USA
    Bioorg Med Chem 15:186-93. 2007
    ....
  40. ncbi Effects of bay substituents on the racemization barriers of perylene bisimides: resolution of atropo-enantiomers
    Peter Osswald
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, 97074 Wurzburg, Germany
    J Am Chem Soc 129:14319-26. 2007
    ..These enantiomers do not racemize in solution at room temperature and, thus, represent the first examples of enantiomerically pure core-twisted perylene bisimides...
  41. pmc Acyclic 1,4-stereocontrol via reductive 1,3-transpositions
    Wei Qi
    119 Chemistry Building, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Org Lett 10:357-9. 2008
    ..The E-alkenes led to the 1,4-syn isomers, while the Z-alkenes led to the 1,4-anti isomers, both with > or =20:1 diastereoselectivity...
  42. ncbi The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase
    Marco Franceschin
    Dipartimento di Chimica, Universita di Roma La Sapienza, Piazzale A Moro 5, 00185 Roma, Italy
    Bioorg Med Chem 16:2292-304. 2008
    ....
  43. doi Dinuclear {(salen)Al} complexes display expanded scope in the conjugate cyanation of alpha,beta-unsaturated imides
    Clément Mazet
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 47:1762-5. 2008
  44. doi Perylene bisimide dimers as fluorescent "glue" for DNA and for base-mismatch detection
    Daniela Baumstark
    Institute for Organic Chemistry, University of Regensburg, 93040 Regensburg, Germany
    Angew Chem Int Ed Engl 47:2612-4. 2008
  45. doi Unprecedented replacement of bridging oxygen atoms in polyoxometalates with organic imido ligands
    Jian Hao
    Department of Chemistry, Tsinghua University, Beijing 100084, China
    Angew Chem Int Ed Engl 47:2626-30. 2008
  46. pmc Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones
    J R Falck
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Bioorg Med Chem Lett 18:1768-71. 2008
    ..Alpha-thiocyanation of chiral N-acyl carboximides proceeds with excellent diastereoselectivity, although partial racemization occurs during subsequent cyclization...
  47. ncbi Layer-by-layer deposited multilayer films of oligo(pyrenebutyric acid) and a perylene diimide derivative: structure and photovoltaic properties
    Lu Zhao
    Key Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology, Department of Chemistry, Tsinghua University, Beijing, People s Republic of China
    Langmuir 24:4380-7. 2008
    ....
  48. pmc Scope and mechanism of formal S(N)2' substitution reactions of a monomeric imidozirconium complex with allylic electrophiles
    Gojko Lalic
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 130:4459-65. 2008
    ..This detailed knowledge of the reaction mechanism provides a rationale for the origins of the observed regio-, diastereo-, and stereoselectivity and of the unusual reactivity profile observed in the reaction...
  49. ncbi The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines
    Maria H Paluchowska
    Department of Medicinal Chemistry, Polish Academy of Science, Smetna 12, 31 343 Krakow, Poland
    Bioorg Med Chem 15:7116-25. 2007
    New, flexible (7, 9, 11 and 13) and rigid (8, 10, 12 and 14) imides with a 1-(m-trifluorophenyl)piperazine fragment and a tetramethylene or a 1e,4e-cyclohexylene spacer, respectively, showed very high affinity (K(i)=0...
  50. ncbi Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction
    Jingqiang Wei
    Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Org Lett 9:4077-80. 2007
    ..Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct...
  51. ncbi Photoluminescence and conductivity of self-assembled pi-pi stacks of perylene bisimide dyes
    Zhijian Chen
    Universitat Wurzburg, Institut fur Organische Chemie and Rontgen Research Center for Complex Material Systems, Am Hubland, 97074 Wurzburg, Germany
    Chemistry 13:436-49. 2007
    ..42 cm(2) V(-1) s(-1) is obtained. Considering the promising self-assembly, semiconducting, and luminescence properties of this dye, it might serve as a useful functional material for nano(opto)electronics...
  52. ncbi Elucidating the mechanism of the asymmetric aza-Michael reaction
    Pim Huat Phua
    Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, UK
    Chemistry 13:4602-13. 2007
    ..The study culminated in the design of a new reaction protocol. By maintaining a low concentration of the aniline substrate during the course of the reaction, significant enhancement of yield and enantioselectivity can be achieved...
  53. ncbi Time-resolved EPR studies of photogenerated radical ion pairs separated by p-phenylene oligomers and of triplet states resulting from charge recombination
    Zachary E X Dance
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208 3113, USA
    J Phys Chem B 110:25163-73. 2006
    ..This SO-ISC mechanism requires the initial RP intermediate and depends strongly on the orientation of the molecular orbitals involved in the charge recombination as well as the magnitude of 2J...
  54. ncbi Mechanism of catalytic aziridination with manganese corrole: the often postulated high-valent Mn(V) imido is not the group transfer reagent
    Michael J Zdilla
    Brown Laboratory, Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA
    J Am Chem Soc 128:16971-9. 2006
    ..Formation of this oxidant is rate limiting in catalysis...
  55. ncbi Chemoselective hydrogenation of imides catalyzed by Cp*Ru(PN) complexes and its application to the asymmetric synthesis of paroxetine
    Masato Ito
    Department of Applied Chemistry, Graduate School of Science and Engineering, Tokyo Institute of Technology, 2 12 1 O okayama, Meguro ku, Tokyo 152 8552, Japan
    J Am Chem Soc 129:290-1. 2007
  56. ncbi Synthesis of protected chiral vicinal diaminoalcohols by diastereoselective intramolecular benzylic substitution from bistrichloroacetimidates
    Christophe Rondot
    Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif sur Yvette Cedex, France
    Org Lett 9:247-50. 2007
    ..The transformation of 2 into other selectively protected aminodiols is also documented. [reaction: see text]...
  57. ncbi Stepwise acid-promoted double-Michael process: an alternative to Diels-Alder cycloadditions for hindered silyloxydiene-dienophile pairs
    Michael E Jung
    Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, USA
    Org Lett 9:375-8. 2007
    ..9:1 mixture of two cycloadducts. Hydrolysis of the major isomer gave the dione 27', a model for the BCD ring system of pentacyclic triterpenes. [reaction: see text]...
  58. ncbi Photoinitiated charge transport in supramolecular assemblies of a 1,7,N,N'-tetrakis(zinc porphyrin)-perylene-3,4:9,10-bis(dicarboximide)
    Richard F Kelley
    Department of Chemistry and International Institute for Nanotechnology, Northwestern University, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 129:3173-81. 2007
    ..The structure of this hierarchical assembly is characterized with the use of solution-phase X-ray scattering techniques and demonstrates both efficient light harvesting and facile charge separation and transport using multiple pathways...
  59. ncbi Power-law blinking in the fluorescence of single organic molecules
    Jacob P Hoogenboom
    Applied Optics Group, Faculty of Science and Technology and Mesa Institute for Nanotechnology, University of Twente, P O Box 217, 7500AE Enschede, The Netherlands
    Chemphyschem 8:823-33. 2007
    ..As a consequence of power-law statistics, single molecule properties like the total number of emitted photons display non-ergodicity...
  60. ncbi An efficient approach to the stereocontrolled synthesis of enamides
    Mathew V J Villa
    WestCHEM, University of Glasgow, Joseph Black Building, University Avenue, Glasgow G12 8QQ, Scotland
    Org Lett 9:1631-3. 2007
    ..the stereocontrolled synthesis of enamides has been developed starting from lactams and amides through the use of imides. This new approach provides access to enamide systems not easily or currently accessible through other approaches.
  61. ncbi Enhanced intersystem crossing via a high energy charge transfer state in a perylenediimide-perylenemonoimide dyad
    Dirk Veldman
    Molecular Materials and Nanosystems, Eindhoven University of Technology, P O Box 513, Eindhoven, NL 5600 MB, The Netherlands
    J Phys Chem A 112:8617-32. 2008
    ..Recombination to T 1, rather than to the ground-state S 0, is required to rationalize the experimental barrier for CR. Finally, we discuss the relevance of these results for electron donor-acceptor films in photovoltaic devices...
  62. ncbi Novel naphthalimide hydroperoxide photonucleases: the role of thiocyclic-fused area and the difference in spectra, photochemistry and photobiological activity
    Yufang Xu
    Shanghai Key Lab of Chemical Biology, Institute of Pesticides Pharmaceuticals, East China University of Science and Technology, PO Box 544, 130Meilong Road, Shanghai 200237, China
    Bioorg Med Chem 11:5427-33. 2003
    ..0-8.5) at 5 microM under 450 nm and showed 'time-controlled' photo-bioactivity. Their thiocycles and the angular conjugated plane have contributions to their binding affinity with DNA and photocleaving efficiency...
  63. ncbi Fluorescence of chromatin DNA induced by antitumoral naphthalimides
    J C Stockert
    , Facultad de Ciencias, , Spain
    Z Naturforsch C 52:408-11. 1997
    ..Fluorescence properties open new and interesting applications for some of these antitumoral and DNA-intercalating naphthalimides...
  64. pmc Epoxide-opening and group-transfer reactions mediated by monomeric zirconium imido complexes
    Suzanne A Blum
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, CA 94720, USA
    J Am Chem Soc 125:14276-7. 2003
    ..The azametallacycles undergo facile cleavage to beta-amino alcohols upon addition of mild acid...
  65. ncbi Syntheses of imido-substituted glycosans and their photocyclisation towards highly functionalised heterotricycles
    S Thiering
    , , Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany
    Carbohydr Res 336:271-82. 2001
    ....
  66. ncbi Ionic perylenetetracarboxdiimides: highly fluorescent and water-soluble dyes for biolabeling
    Jianqiang Qu
    Max Planck Institut fur Polymerforschung, Ackermannweg 10, 55128 Mainz, Germany
    Angew Chem Int Ed Engl 43:1528-31. 2004
  67. ncbi Calix[4]arene-functionalized naphthalene and perylene imide dyes
    Myroslav O Vysotsky
    Fachbereich Chemie und Pharmazie, Abteilung Lehramt Chemie, Johannes Gutenberg Universitat, Duesbergweg 10 14, D 55099 Mainz, Germany
    Org Lett 4:2901-4. 2002
    ..UV-vis and fluorescence studies have been carried out for the perylene bis-calix[4]arene dyes...
  68. ncbi Rebek imides and their adenine complexes: preferences for Hoogsteen binding in the solid state and in solution
    Ronald K Castellano
    Laboratorium fur Organische Chemie, ETH Zentrum, Zurich, Switzerland
    Chemistry 8:118-29. 2002
    Rebek imides (3), formed from Kemp's triacid, were developed in the mid-1980's as model receptors for adenine derivatives...
  69. ncbi Substituent effects on monoboronic acid sensors for saccharides based on N-phenyl-1,8-naphthalenedicarboximides
    Haishi Cao
    Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA
    J Org Chem 69:2959-66. 2004
    ..The effects of substituent on all six probes lend support to the proposed photoelectrochemical model...
  70. ncbi Synthesis and structure-activity relationship of antifungal coniothyriomycin analogues
    Karsten Krohn
    Department of Chemistry, University of Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany
    J Antibiot (Tokyo) 56:296-305. 2003
    ..Structure-activity studies showed that antifungal activity was retained by replacement of phenylacetic acids by benzoic acids in the imide structure but diminished by hydrogenation of the fumaric ester part...
  71. ncbi Photoinduced electron transfer in bisporphyrin-diimide complexes
    Lucia Flamigni
    Istituto ISOF CNR, Bologna, Italy
    Chemistry 8:3938-47. 2002
    ..The process is identified as an electron transfer from the excited singlet of the porphyrinic host to the imide guest, which yields charge-separated states with a lifetime of 710 ps for ZnH(+)-NIN(-) and 260 ps for ZnH(+)-PIN(-)...
  72. pmc Palladium-catalyzed coupling of ammonia with aryl chlorides, bromides, iodides, and sulfonates: a general method for the preparation of primary arylamines
    Giang D Vo
    Department of Chemistry, University of Illinois, 600 South Mathews Avenue, Urbana, Illinois 61801, USA
    J Am Chem Soc 131:11049-61. 2009
    ..The utility of this method to generate amides, imides, and carbamates is illustrated by a one-pot synthesis of a small library of these carbonyl compounds from aryl ..
  73. ncbi 252Cf plasma desorption mass spectrometry in the synthesis of porphyrin model systems
    J S Lindsey
    Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213
    Anal Chem 64:2804-14. 1992
    ..The appended groups include carboxylic acids, amides, imides, chloroacetamides, Fmoc-protected amino acids, aromatic amines, nitriles, alkynes, alkenes, esters, active esters, ..
  74. ncbi One-electron reduction of N-chlorinated and N-brominated species is a source of radicals and bromine atom formation
    David I Pattison
    The Heart Research Institute, Newtown, NSW, Australia
    Chem Res Toxicol 24:371-82. 2011
    ..In the present study, rate constants for the reduction of N-halogenated amines, amides, and imides to model potential biological substrates have been determined...
  75. ncbi [Effect of dimethyladipimidate and dimethylsuberimidate on cell-cell adhesion in rat fibroblasts]
    P Pippia
    Istituto di Fisiologia Generale e Chimica Biologica, Universita di Sassari
    Boll Soc Ital Biol Sper 66:945-52. 1990
    ..adhesion brought about by cross-linking reagents indicates that a) EDTA-released cells are more sensitive to both imides than those released with trypsin, b) DMA is more effective on trypsin-released cells and c) DMS is more effective ..
  76. ncbi Cytotoxicity of imides-N-alkyl semicarbazones, thiosemicarbazones, acetylhydrazones and related derivatives
    I H Hall
    Division of Medicinal Chemistry and Natural Products, University of North Carolina at Chapel Hill 27599, USA
    Anticancer Drugs 6:147-53. 1995
    ....
  77. doi Columnar benzoperylene-hexa- and tetracarboxylic imides and esters: synthesis, mesophase stabilisation and observation of charge-transfer interactions between electron-donating esters and electron-accepting imides
    Julien Kelber
    Centre de Recherche Paul Pascal, Universite de Bordeaux and CNRS, 115, Avenue Schweitzer, 33600 Pessac, France
    Chemistry 17:8145-55. 2011
    ..29 and 0.35 eV...
  78. ncbi On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics
    Amit S Kalgutkar
    Pharmacokinetics, Dynamics, and Metabolism Department, Pfizer Global Research and Development, Groton, CT 06340, USA
    Curr Drug Metab 3:379-424. 2002
    ..g. procainamide), single electron N-oxidation of imides (e.g. phenytoin), or alpha-carbon oxidations of arylalkyl- or alkylamines (e.g...
  79. pmc Characterization of structural variations in the peptidoglycan of vancomycin-susceptible Enterococcus faecium: understanding glycopeptide-antibiotic binding sites using mass spectrometry
    Gary J Patti
    Department of Chemistry, Washington University, St Louis, Missouri 63130, USA
    J Am Soc Mass Spectrom 19:1467-75. 2008
    ..of muropeptides containing O-acetylation, amidation, hydroxylation, and the number of species forming cyclic imides. The varieties of muropeptides on which the modifications are detected suggest that significant processing occurs ..
  80. ncbi The aminolysis of N-aroyl beta-lactams occurs by a concerted mechanism
    Wing Y Tsang
    Department of Chemical and Biological Sciences, The University of Huddersfield, Queensgate, Huddersfield HD1 3DH, UK
    Org Biomol Chem 5:485-93. 2007
    N-aroyl beta-lactams are imides with exo- and endocyclic acyl centres which react with amines in aqueous solution to give the ring opened beta-lactam aminolysis product...
  81. ncbi N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system
    Nara L M Quintão
    Programa de Mestrado em Ciências Farmacêuticas, Universidade do Vale do Itajai, Rua Uruguai, n 458, Bloco 27, CCS, Sala 314, CEP 88202 302, Itajai, Santa Catarina, Brazil
    Anesth Analg 110:942-50. 2010
    In recent years, cyclic imides have attracted the attention of the scientific community because of their promising therapeutic potential...
  82. ncbi Ligands for the common allosteric site of acetylcholine M2-receptors: development and application
    U Holzgrabe
    Department of Pharmaceutical Chemistry, University of Wurzburg, Germany
    Pharm Acta Helv 74:149-55. 2000
    ..Previous molecular modelling studies revealed two positive charges and two aromatic imides in a sandwich-like arrangement to be essential for a high allosteric potency...
  83. ncbi n-Type field effect transistors based on rigid rod and liquid crystalline alternating copoly(benzobisoxazole) imides containing perylene and/or naphthalene
    Nagesh B Kolhe
    Polymer Science and Engineering Division, National Chemical Laboratory, Pune 411008, Maharashtra, India
    J Phys Chem B 114:16694-704. 2010
    ....
  84. ncbi Conjugate addition reactions of alpha-aminoalkylcuprates with alpha, beta-alkenyl-, alpha,beta-alkynyl-, alpha,beta-beta,gamma-allenyl-, and alpha,beta-gamma,delta-dienyl carboxylic acid derivatives, nitriles, and sulfoxides
    R K Dieter
    Hunter Laboratory, Department of Chemistry, Clemson University, Clemson, South Carolina 29634 0973, USA
    J Org Chem 65:8715-24. 2000
    ..2LiCl participate in 1,4-addition reactions with alpha, beta-unsaturated esters, thiol esters, imides, and nitriles in poor to excellent yields depending upon the electron-withdrawing substituent and the substitution ..
  85. ncbi Merocyanine dyes containing imide functional groups: synthesis and studies on hydrogen bonding to melamine receptors
    Frank Wurthner
    Institut fur Organische Chemie, Universitat Wurzburg, Am Hubland, D 97074 Wurzburg, Germany
    J Org Chem 68:8943-9. 2003
    ..Although the binding constants for triple hydrogen bonding between imides and melamines are rather weak in chloroform, they proved to be strong enough to facilitate dissolution of some of ..
  86. ncbi Headspace solid-phase microextraction--a tool for new insights into the long-term thermo-oxidation mechanism of polyamide 6.6
    M Groning
    Department of Polymer Technology, The Royal Institute of Technology KTH, Stockholm, Sweden
    J Chromatogr A 932:1-11. 2001
    ..In groups A, B and C several new thermo-oxidation products of polyamide 6.6 were identified including cyclic imides, pyridines and structural fragments from the original polyamide chain...
  87. ncbi Choline-derivative-based ionic liquids
    Juliusz Pernak
    Poznan University of Technology, Poznan, Poland
    Chemistry 13:6817-27. 2007
    ..choline derivative-based ionic liquids in the forms of chlorides, acesulfamates, and bis(trifluoromethylsulfonyl)imides have been prepared and their physical properties (density, viscosity, solubility, and thermal stability) have been ..
  88. ncbi Molecular probes for P2X7 receptor studies
    Hendra Gunosewoyo
    School of Chemistry, University of Sydney, NSW 2006 Australia
    Curr Med Chem 14:1505-23. 2007
    ..including ATP analogues (oxidized ATP), dyes (Brilliant Blue G), tyrosine derivatives (KN-62 and KN-04), cyclic imides, adamantane and benzamide derivatives...
  89. ncbi 18-Crown-6 and dibenzo-18-crown-6 assisted extraction of cesium from water into room temperature ionic liquids and its correlation with stability constants for cesium complexes
    Andrey G Vendilo
    State Research Institute of Reagents and High Purity Substances IREA, Bogorodskii val 3, 107258, Moscow, Russia
    Molecules 14:5001-16. 2009
    ..of Cs(+) into four conventional (1-butyl-3-methylimidazolium hexafluorophosphate and bis[trifluoromethyl)sulphonyl]imides of 1-butyl-3-methylimidazolium, 1-hexyl-3-methylimidazolium, and 1-(2-ethylhexyl)-3- methylimidazolium) and two ..
  90. ncbi Selective DNA binding of (N-alkylamine)-substituted naphthalene imides and diimides to G+C-rich DNA
    Z R Liu
    Department of Chemistry, Florida State University, Tallahassee 32306 3006, USA
    J Biomol Struct Dyn 14:331-9. 1996
    Alkylamine-substituted naphthalene imides and diimides bind DNA by intercalation and have applications as anticancer agents...
  91. ncbi Convenient synthesis and antimicrobial activity of new 3-substituted 5-(benzofuran-2-yl)-pyrazole derivatives
    Bakr F Abdel-Wahab
    Applied Organic Chemistry Department, National Research Center, Dokki, Giza, Egypt
    Arch Pharm (Weinheim) 341:734-9. 2008
    ..Various new compounds such as imides 5 and 6, acyl hydrazones 7 and 8, bi-pyrazoles 9-12, and 1,3-thiazole derivatives 14 and 15 were prepared from ..
  92. ncbi Photophysics and redox properties of rylene imide and diimide dyes alkylated ortho to the imide groups
    Joseph E Bullock
    Department of Chemistry and Argonne Northwestern Solar Energy Research ANSER Center, Northwestern University, Evanston, Illinois 60208 3113
    J Phys Chem B 114:1794-802. 2010
    ..attach phenethyl groups derived from styrene to positions ortho to the imide groups in a variety of rylene imides and diimides including naphthalene-1,8-dicarboximide (NMI), naphthalene-1,4:5,8-bis(dicarboximide) (NI), perylene-..
  93. ncbi Radical alkylphosphanylation of olefins with stannylated or silylated phosphanes and alkyl iodides
    Marie Céline Lamas
    Organisch Chemisches Institut, University of Münster, Corrensstrasse 40, 48149 Münster, Germany
    Org Lett 13:2236-9. 2011
    ..derived from the corresponding alkyl iodides to activated olefins such as α,β-unsaturated esters, amides, imides, nitriles, and sulfones are described...
  94. ncbi Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors
    Hélène Hénon
    Laboratoire SEESIB, Universite Blaise Pascal, UMR 6504 du CNRS, 63177 Aubiere, France
    Eur J Pharmacol 554:106-12. 2007
    ..course of structure-activity relationship studies on granulatimide analogues, we have synthesized a series of bis-imides, in which the imidazole moiety was replaced by an imide heterocycle...
  95. ncbi Miscibility of ionic liquids with polyhydric alcohols
    Anna Makowska
    Faculty of Chemistry, University of Warsaw, Zwirki i Wigury 101, 02 089 Warsaw, Poland
    J Phys Chem B 114:2504-8. 2010
    ..Comparing the miscibility of 1,2-ethanediol with 1-alkyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imides, it can be seen that surprisingly, T(c)([emim](+)) < T(c)([bmim](+)) < T(c)([hmim](+))...
  96. ncbi Direct organocatalytic asymmetric aldol reaction of alpha-isothiocyanato imides to alpha-ketoesters under low ligand loading: a doubly stereocontrolled approach to cyclic thiocarbamates bearing chiral quaternary stereocenters
    Xianxing Jiang
    State Key Laboratory of Applied Organic Chemistry, Institute of Biochemistry and Molecular Biology, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, 730000, China
    Org Lett 12:1544-7. 2010
    The first doubly stereocontrolled organocatalytic asymmetric aldol reaction of alpha-isothiocyanato imides with alpha-ketoesters by using rosin-derived tertiary amine-thiourea under low ligand loading to form cyclic thiocarbamates bearing ..
  97. ncbi Water soluble cationic perylene derivatives as possible telomerase inhibitors: the search for selective G-quadruplex targeting
    Emanuela Micheli
    Dipartimento di Chimica, Sapienza Universita di Roma, Roma, Italy
    Mini Rev Med Chem 9:1622-32. 2009
    ..Here, we mean to critically analyze the class of hydrosoluble perylene di-imides (HPDIs), which offers the intriguing possibility to fix the hydrophobic molecule moiety (perylene) able to bind to ..
  98. ncbi Direct entry to peptidyl ketones via SmI2-mediated C-C bond formation with readily accessible N-peptidyl oxazolidinones
    Tina Mittag
    Center for Insoluble Protein Structures, Department of Chemistry and Interdisciplinary Nanoscience Center, University of Aarhus, Langelandsgade 140, 8000 Aarhus C, Denmark
    J Org Chem 73:1088-92. 2008
    ..The requisite peptide imides were easily prepared by solution-phase peptide synthesis starting from an N-acyl oxazolidinone derivative of an ..
  99. ncbi Cytotoxic cycloartane triterpene and rare isomeric bisclerodane diterpenes from the leaves of Polyalthia longifolia var. pendula
    Koneni V Sashidhara
    Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India
    Bioorg Med Chem Lett 20:5767-71. 2010
    A 24-methylenecycloartane-3 β, 16 β, 23 β-triol, Longitriol (1), rare bisclerodane imides, Longimide A (2) and previously known Longimide B (3) were isolated from ethanolic extract of the leaves of Polyalthia longifolia var. pendula...
  100. ncbi Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives
    Fernanda Mahle
    Núcleo de Investigações Químico Farmacêuticas CCS, Universidade do Vale do Itajai, Caixa Postal 360, CEP 88302 202, Itajai, Santa Catarina, Brazil
    Eur J Med Chem 45:4761-8. 2010
    This paper describes the synthesis of new cyclic imides obtained by reaction with N-antipyrine-3,4-dichloromaleimides and different aromatic amines...
  101. ncbi [A dicarboxylate monoamide amidohydrolase (half-amidase) from Alcaligenes eutrophus 112R4]
    Yingzi Zhang
    Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China
    Wei Sheng Wu Xue Bao 43:87-93. 2003
    ..The enzyme catalyzed the hydrolysis of monoamidated dicarboxylates, which were the hydrolyzing products of cyclic imides by imidase, to dicarboxylates and ammonia...

Research Grants27

  1. TOTAL SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    JIN CHA; Fiscal Year: 2007
    ..2) Iow-valent titanium-mediated cyclopropanation reactions of carboxylic acid derivatives and related coupling of imides. Among specific target molecules for the next budget period are ingenol (la), as a prominent member of the ..
  2. SYNTHESIS AND ELECTROCHEMISTRY OF THIOPHENE IMIDES
    RONALD NOFTLE; Fiscal Year: 2000
    This goal of the proposed research is the synthesis and characterization of a new series of thiophene imides which can be polymerized to create novel materials having an extensive number of applications...
  3. ANALOGS OF METHYLLYCACONITINE--SELECTIVE NICOTINIC AGENT
    STEPHEN BERGMEIER; Fiscal Year: 2000
    ..We will also prepare differently substituted imides in order to determine the optimal placement with regard to potency and receptor subtype specificity...
  4. Catalytic, Asymmetric Aziridination using (Salen)metal Catalysts
    Mary Watson; Fiscal Year: 2009
    ..Specifically, this project will develop a one-step transformation of readily accessible enones and unsaturated imides into enantioenriched aziridines using easily prepared catalysts and readily available nitrogen sources...
  5. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..to the synthesis of bridged tricyclic aminoketones via intramolecular photocycloaddition of vinylogous imides. The development of the asymmetric variant of the photocycloaddition reaction will be examined, in the context of ..
  6. ACYCLIC STEREOCONTROL IN RADICAL REACTIONS
    MUKUND SIBI; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  7. Natural Product Leads for Drug Development
    KATHLYN PARKER; Fiscal Year: 2009
    ..Molecular modeling will allow the design of candidates for more active drugs. Candidates will be evaluated in the squalene synthase assay. Collaborations for the medicinal chemistry components of the project have been arranged. ..
  8. Intramolecular Aryne Cycloadditions and Rearrangements
    KEITH BUSZEK; Fiscal Year: 2008
    ..abstract_text> ..
  9. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  10. Image-guided Ultrasound-triggered Tumor Therapy
    Alexander Klibanov; Fiscal Year: 2007
    ..Monitor blood flow within the tumor after treatment. Perform final optimization of the drug carrier formulation and ultrasound activation parameters. ..
  11. Synthesis of Polyketides and Terpenes
    David A Evans; Fiscal Year: 2010
    ..As a consequence, organic synthesis is a critical discipline that continues to have an important impact on the fields of both medicine and biology. ..
  12. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  13. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  14. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  15. Wearable Organic Electric Film RFID Sensors for Monitoring of Airborne Toxicants
    Radislav A Potyrailo; Fiscal Year: 2010
    ..This new sensing approach will provide a wearable, cost-effective, selective sensor for de- tection of toxic volatile species. ..
  16. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  17. STRATEGIES AND METHODS IN SYNTHESIS OF NATURAL PRODUCTS
    KATHLYN PARKER; Fiscal Year: 2003
    ..During the period which corresponds to this proposal, we plan to apply our new methodology to the synthesis of deacetylravidomycin and kidamycin, representatives of the remaining two major classes. ..
  18. SYNTHESIS OF NOVEL BIOLOGICALLY ACTIVE NATURAL PRODUCTS
    ROBERT BOECKMAN; Fiscal Year: 2002
    ..The hypothesis that an internal chelate of suitably disposed oxygen functions permits the modification of the ring conformation from half-chair to half-boat will be tested. ..
  19. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  20. ASYMMETRIC SYNTHESIS OF VANCOMYCIN ANTIBIOTICS
    David Evans; Fiscal Year: 2001
    ..During the course of this project we intend to confirm (correct) the absolute stereochemical assignments of the principal members of this family by total synthesis. ..
  21. Diazeniumodiolate Reactivity in Lung Surfactant Media
    Keith Davies; Fiscal Year: 2005
    ....
  22. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  23. ASYMMETRIC SYNTHESIS OF IONOPHORE/MACROLIDE ANTIBIOTICS
    David Evans; Fiscal Year: 2005
    ..Our goal has been to set in place all of the reactions necessary for the rapid assemblage of any polyketide target structure. ..
  24. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  25. Chemical Mechanism of Guanine Deamination
    Rainer Glaser; Fiscal Year: 2003
    ..5. The computational studies will include studies of the bimolecular reaction mechanisms for dediazoniation of the nucleobase diazonium ions. ..
  26. NEW DEVELOPMENTS IN ORGANOCOPPER CHEMISTRY
    R Dieter; Fiscal Year: 2004
    ..The proposed synthetic routes to pyrrolidine aza sugars will develop the potential synthetic power of alpha-aminoalkylcuprate chemistry. ..
  27. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....