triterpenes

Summary

Top Publications

  1. ncbi Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:4758-65. 2006
  2. pmc The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]
    Dongbo Liu
    Hunan Agricultural University, Changsha, Hunan, China
    PLoS ONE 7:e36146. 2012
  3. ncbi Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways
    Haibo Mou
    Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, People s Republic of China
    Toxicol In Vitro 25:1027-32. 2011
  4. ncbi Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts
    Sebastian Jäger
    Carl Gustav Carus Institute, Am Eichhof 30, D 75223 Niefern Oschelbronn, Germany
    Molecules 14:2016-31. 2009
  5. ncbi Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
  6. pmc HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
    Paul W Keller
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Building 50, Room 1517, 50 South Drive, MSC 8025, Bethesda, MD 20892, USA
    J Virol 85:1420-8. 2011
  7. ncbi Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid
    Jeong Hyung Lee
    Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, 52 Aueun Dong, Yuseong Gu, Daejeon, Republic of Korea
    Biochem Pharmacol 72:1311-21. 2006
  8. pmc Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol
    Regina Cencic
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e5223. 2009
  9. ncbi Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
    Apoptosis 16:1028-41. 2011
  10. ncbi Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes
    Stephane Fontanay
    SRSMC, Nancy University, CNRS, France
    J Ethnopharmacol 120:272-6. 2008

Detail Information

Publications346 found, 100 shown here

  1. ncbi Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice
    Huanjie Yang
    The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Res 66:4758-65. 2006
    ..Our results show that Celastrol is a natural proteasome inhibitor that has a great potential for cancer prevention and treatment...
  2. pmc The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation [corrected]
    Dongbo Liu
    Hunan Agricultural University, Changsha, Hunan, China
    PLoS ONE 7:e36146. 2012
    ..It is also a fungus with strong wood degradation ability with potential in bioenergy production. However, genes, pathways and mechanisms of these functions are still unknown...
  3. ncbi Celastrol induces apoptosis in non-small-cell lung cancer A549 cells through activation of mitochondria- and Fas/FasL-mediated pathways
    Haibo Mou
    Department of Medical Oncology, The First Affiliated Hospital, School of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang Province 310003, People s Republic of China
    Toxicol In Vitro 25:1027-32. 2011
    ..These results demonstrate that celastrol can induce apoptosis of human NSCLC A549 cells through activation of both mitochondria- and FasL-mediated pathways...
  4. ncbi Pentacyclic triterpene distribution in various plants - rich sources for a new group of multi-potent plant extracts
    Sebastian Jäger
    Carl Gustav Carus Institute, Am Eichhof 30, D 75223 Niefern Oschelbronn, Germany
    Molecules 14:2016-31. 2009
    Pentacyclic triterpenes are secondary plant metabolites widespread in fruit peel, leaves and stem bark...
  5. ncbi Oleanolic acid and ursolic acid: research perspectives
    Jie Liu
    Inorganic Carcinogenesis Section, Laboratory of Comparative Carcinogenesis, NCI at NIEHS, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    J Ethnopharmacol 100:92-4. 2005
    ..A briefly commentary is attempted here for their research perspectives...
  6. pmc HIV-1 maturation inhibitor bevirimat stabilizes the immature Gag lattice
    Paul W Keller
    Laboratory of Structural Biology Research, National Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Building 50, Room 1517, 50 South Drive, MSC 8025, Bethesda, MD 20892, USA
    J Virol 85:1420-8. 2011
    ..In both cases, the observed failure to assemble mature capsids correlates with the loss of infectivity...
  7. ncbi Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid
    Jeong Hyung Lee
    Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, 52 Aueun Dong, Yuseong Gu, Daejeon, Republic of Korea
    Biochem Pharmacol 72:1311-21. 2006
    ....
  8. pmc Antitumor activity and mechanism of action of the cyclopenta[b]benzofuran, silvestrol
    Regina Cencic
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    PLoS ONE 4:e5223. 2009
    ..One flavagline, silvestrol, is capable of modulating chemosensitivity in a mechanism-based mouse model...
  9. ncbi Celastrol inhibits tumor cell proliferation and promotes apoptosis through the activation of c-Jun N-terminal kinase and suppression of PI3 K/Akt signaling pathways
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore
    Apoptosis 16:1028-41. 2011
    ..Overall, our results indicate that celastrol can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and down-regulation of anti-apoptotic protein expression...
  10. ncbi Ursolic, oleanolic and betulinic acids: antibacterial spectra and selectivity indexes
    Stephane Fontanay
    SRSMC, Nancy University, CNRS, France
    J Ethnopharmacol 120:272-6. 2008
    ....
  11. ncbi Chemical constituents and pharmacological properties of Poria cocos
    Jose Luis Rios
    Department of Pharmacology, University of Valencia, Valencia, Spain
    Planta Med 77:681-91. 2011
    ..In several of the studies reviewed, the inhibitory effects of triterpenes on phospholipase A (2) (PLA (2)) have been clearly demonstrated...
  12. pmc Therapeutic suppression of translation initiation modulates chemosensitivity in a mouse lymphoma model
    Marie Eve Bordeleau
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    J Clin Invest 118:2651-60. 2008
    ..These results establish that targeting translation initiation can restore drug sensitivity in vivo and provide an approach to modulating chemosensitivity...
  13. ncbi Molecular targets of celastrol derived from Thunder of God Vine: potential role in the treatment of inflammatory disorders and cancer
    Radhamani Kannaiyan
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore
    Cancer Lett 303:9-20. 2011
    ..This review describes the various molecular targets of celastrol, cellular responses to celastrol, and animal studies with celastrol in cancer and other inflammatory disorders...
  14. ncbi Effects of triterpenes on the immune system
    Jose Luis Rios
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n 46100 Burjassot, Valencia, Spain
    J Ethnopharmacol 128:1-14. 2010
    b>Triterpenes, which comprise a broad chemical group of active principles, are implicated in the mechanisms of action and pharmacological effects of many medicinal plants used in folk medicine against diseases in which the immune system is ..
  15. ncbi Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
    Michelle A Blaskovich
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 63:1270-9. 2003
    ..These results give strong support for pharmacologically targeting the JAK/STAT3 signaling pathway for anticancer drug discovery...
  16. ncbi Celastrol inhibits breast cancer cell invasion via suppression of NF-ĸB-mediated matrix metalloproteinase-9 expression
    Yoonseo Kim
    School of Life Sciences and Biotechnology, Korea University, Seoul, Korea
    Cell Physiol Biochem 28:175-84. 2011
    ..In this study, we investigated the effect of celastrol on the migration and invasion of human breast carcinoma cells...
  17. pmc Inhibition of Wnt signaling by cucurbitacin B in breast cancer cells: reduction of Wnt-associated proteins and reduced translocation of galectin-3-mediated β-catenin to the nucleus
    Sumana Dakeng
    Mahidol University, Bangkok, Thailand
    J Cell Biochem 113:49-60. 2012
    The cucurbitacins are tetracyclic triterpenes found in plants of the family Cucurbitaceae. Cucurbitacins have been shown to have anti-cancer and anti-inflamatory activities...
  18. ncbi Molecular cloning, characterization, and differential expression of a lanosterol synthase gene from Ganoderma lucidum
    Chang Hua Shang
    College of Life Sciences, Nanjing Agricultural University, Key Laboratory for Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Jiangsu, People s Republic of China
    Biosci Biotechnol Biochem 74:974-8. 2010
    ..lucidum), which produces triterpenes. The cDNA of the LS (GenBank accession no...
  19. ncbi Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions
    Ming Shi Shiao
    Department of Medical Research and Education, Taipei Veterans General Hospital, Taiwan 11217
    Chem Rec 3:172-80. 2003
    ..A combination treatment of lovastatin and Ganoderma triterpenoids in animal studies has exhibited a potential anticancer effect...
  20. ncbi Celastrol: Molecular targets of Thunder God Vine
    Antero Salminen
    Department of Neurology, Institute of Clinical Medicine, School of Medicine, University of Eastern Finland, P O Box 1627, FIN 70211 Kuopio, Finland
    Biochem Biophys Res Commun 394:439-42. 2010
    ..Celastrol needs still to pass several hurdles, e.g. ADMET assays, before it can enter the armoury of western drugs...
  21. pmc Natural proteasome inhibitor celastrol suppresses androgen-independent prostate cancer progression by modulating apoptotic proteins and NF-kappaB
    Yao Dai
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 5:e14153. 2010
    ..In the current study, we aim to test the hypothesis that celastrol suppresses AIPC progression via inhibiting the constitutive NF-κB activity as well as modulating the Bcl-2 family proteins...
  22. ncbi Ursolic acid: an anti- and pro-inflammatory triterpenoid
    Yasutaka Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    Mol Nutr Food Res 52:26-42. 2008
    ..This review summarizes previous and current information regarding UA, and provides new insights into the underlying molecular mechanisms of its activities...
  23. pmc Drugs that target specificity proteins downregulate epidermal growth factor receptor in bladder cancer cells
    Gayathri Chadalapaka
    Department of Veterinary Physiology and Pharmacology, Texas A and M University, 4466 TAMU, Veterinary Research Building 410, College Station, TX 77843 4466, USA
    Mol Cancer Res 8:739-50. 2010
    ..Thus, compounds such as curcumin and BA that downregulate Sp transcription factors represent a novel class of anticancer drugs that target EGFR in bladder cancer cells and tumors by inhibiting receptor expression...
  24. ncbi Clinically useful anticancer, antitumor, and antiwrinkle agent, ursolic acid and related derivatives as medicinally important natural product
    Nighat Sultana
    Pharmaceutical Research Center, PCSIR Laboratories Complex, Karachi, Pakistan
    J Enzyme Inhib Med Chem 26:616-42. 2011
    ..This review article contains fourteen medicinally important ursolic acid derivatives and 351 references...
  25. ncbi Suppression of the inflammatory response by triterpenes isolated from the mushroom Ganoderma lucidum
    Shailesh Dudhgaonkar
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int Immunopharmacol 9:1272-80. 2009
    ..In conclusion, the anti-inflammatory and anti-proliferative effects of GLT on macrophages are mediated through the inhibition of NF-kappaB and AP-1 signaling pathways...
  26. ncbi Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells
    Vivian W Y Lui
    Cancer Signaling Laboratory, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong Special Administrative Region
    Carcinogenesis 30:2085-94. 2009
    ..Taken together, our results suggested that Cucurbitacin I may be a potent chemopreventive agent for NPC with anti-invasion and anoikis-sensitizing activities...
  27. ncbi Cucurbitacins and cucurbitane glycosides: structures and biological activities
    Jian Chao Chen
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, Yunnan, P R China
    Nat Prod Rep 22:386-99. 2005
    ..According to the characteristics of their structures, cucurbitacins are divided into twelve categories. The biological effects of the cucurbitacins are also covered...
  28. pmc The novel plant-derived agent silvestrol has B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo
    David M Lucas
    Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
    Blood 113:4656-66. 2009
    ..These data indicate silvestrol has efficacy against B cells in vitro and in vivo and identify translational inhibition as a potential therapeutic target in B-cell leukemias...
  29. ncbi Ursolic acid enhances nitric oxide and tumor necrosis factor-alpha production via nuclear factor-kappaB activation in the resting macrophages
    H J You
    Department of Pharmacy, College of Pharmacy, Chosun University, Kwangju, South Korea
    FEBS Lett 509:156-60. 2001
    ..These results demonstrate that UA stimulates NO and TNF-alpha release and is able to upregulate iNOS and TNF-alpha expression through NF-kappaB transactivation in the resting macrophages...
  30. ncbi Betulinic acid and its derivatives: a review on their biological properties
    Perumal Yogeeswari
    Pharmacy Department, Birla Institute of Technology and Science, Pilani 333031, India
    Curr Med Chem 12:657-66. 2005
    ..Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated...
  31. ncbi Chemistry, biological activity, and chemotherapeutic potential of betulinic acid for the prevention and treatment of cancer and HIV infection
    Robert H Cichewicz
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Med Res Rev 24:90-114. 2004
    ....
  32. pmc Celastrol suppresses angiogenesis-mediated tumor growth through inhibition of AKT/mammalian target of rapamycin pathway
    Xiufeng Pang
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China
    Cancer Res 70:1951-9. 2010
    ..Taken together, our results suggest that Celastrol targets the AKT/mTOR/P70S6K pathway, which leads to suppression of tumor growth and angiogenesis...
  33. ncbi Biosynthesis of triterpenoid saponins in plants
    Kosmas Haralampidis
    Sainsbury Laboratory, John Innes Centre, Norwich, UK
    Adv Biochem Eng Biotechnol 75:31-49. 2002
    ..Progress has also been made in the characterisation of saponin glucosyltransferases. This review outlines these developments, with particular emphasis on triterpenoid saponins...
  34. ncbi Celastrols as inducers of the heat shock response and cytoprotection
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL 60208, USA
    J Biol Chem 279:56053-60. 2004
    ..These results suggest that celastrols exhibit promise as a new class of pharmacologically active regulators of the heat shock response...
  35. ncbi Pharmacological properties of the ubiquitous natural product betulin
    Sami Alakurtti
    Faculty of Pharmacy, Division of Pharmaceutical Chemistry, University of Helsinki, Helsinki, Finland
    Eur J Pharm Sci 29:1-13. 2006
    ..Moreover, it is non-toxic up to 500 mg/kg body weight in mice. The literature concerning derivatization of betulin for structure-activity relationship (SAR) studies and its pharmacological properties is reviewed...
  36. ncbi Cucurbitacin E, a tetracyclic triterpenes compound from Chinese medicine, inhibits tumor angiogenesis through VEGFR2-mediated Jak2-STAT3 signaling pathway
    Yanmin Dong
    Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China
    Carcinogenesis 31:2097-104. 2010
    Cucurbitacin E (CuE, α-elaterin), a tetracyclic triterpenes compound from folk traditional Chinese medicine plants, has been shown to inhibit cancer cell growth, inflammatory response and bilirubin-albumin binding...
  37. ncbi Betulinic acid protects against cerebral ischemia-reperfusion injury in mice by reducing oxidative and nitrosative stress
    Qing Lu
    Department of Pharmacology, University Medical Center, Johannes Gutenberg University, Mainz, Germany
    Nitric Oxide 24:132-8. 2011
    ..This is likely to result from a reduction of oxidative stress (by downregulation of NOX2) and nitrosative stress (by reduction of nNOS and iNOS), and an enhancement of blood flow (by upregulation of eNOS)...
  38. ncbi Celastrol causes apoptosis and cell cycle arrest in rat glioma cells
    Pengfei Ge
    Department of Neurosurgery, First Hospital of Jilin University, Changchun, China
    Neurol Res 32:94-100. 2010
    ..Taken together, our data suggest that celastrol can suppress proteasome activity and induce apoptosis and cell cycle arrest in C6 glioma cells, which make it be a potential drug for glioma...
  39. ncbi Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells
    Chi Tai Yeh
    National Institute of Cancer Research, Zhunan, Taiwan, ROC
    Cancer Lett 285:73-9. 2009
    Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata were evaluated for their in vitro cytotoxic data against various cancer cell types...
  40. ncbi Cucurbitacin B inhibits STAT3 and the Raf/MEK/ERK pathway in leukemia cell line K562
    Kin Tak Chan
    Department of Technology and Product Development, CK Life Sciences Int l, Holdings Inc, 2 Dai Fu Street, Tai Po Industrial Estate, Hong Kong SAR, China
    Cancer Lett 289:46-52. 2010
    ..Western blotting analysis of cell signaling molecules indicated that cucurbitacin B inhibits STAT3 activation and the Raf/MEK/ERK pathway in the K562 cells...
  41. ncbi The induction of G2/M cell-cycle arrest and apoptosis by cucurbitacin E is associated with increased phosphorylation of eIF2alpha in leukemia cells
    Yanchun Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, PR China
    Anticancer Drugs 21:389-400. 2010
    ....
  42. ncbi New antioxidant and antiglycation active triterpenoid saponins from the root bark of Aralia taibaiensis
    Linlin Bi
    Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xi an 710032, PR China
    Fitoterapia 83:234-40. 2012
    ..Compounds 1-5 exhibited moderate effects on antioxidant and antiglycation activities, which correlated with treatment of diabetes mellitus...
  43. ncbi Amelioration of obesity and glucose intolerance in high-fat-fed C57BL/6 mice by anthocyanins and ursolic acid in Cornelian cherry (Cornus mas)
    Bolleddula Jayaprakasam
    Bioactive Natural Products and Phytoceuticals, Department of Horticulture, Michigan State University, East Lansing, Michigan 48824, USA
    J Agric Food Chem 54:243-8. 2006
    ..Overall, these data suggest that anthocyanins and ursolic acid purified from C. mas fruits have biological activities that improve certain metabolic parameters associated with diets high in saturated fats and obesity...
  44. pmc Induction of heat shock proteins in cerebral cortical cultures by celastrol
    Ari M Chow
    Centre for the Neurobiology of Stress, Department of Biological Sciences, University of Toronto Scarborough, 1265 Military Trail, Toronto, ON M1C 1A4, Canada
    Cell Stress Chaperones 18:155-60. 2013
    ....
  45. pmc Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
    Bokyung Sung
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 285:11498-507. 2010
    ..Overall, our results demonstrate that celastrol can potentiate the apoptotic effects of TRAIL through down-regulation of cell survival proteins and up-regulation of death receptors via the ROS-mediated up-regulation of CHOP pathway...
  46. pmc Effective treatment of rat adjuvant-induced arthritis by celastrol
    R Cascão
    Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal
    Autoimmun Rev 11:856-62. 2012
    ..Furthermore, we find that early inhibition of Th17 cells polarization ameliorates arthritis but it is not as effective as celastrol...
  47. pmc Ursolic acid protects diabetic mice against monocyte dysfunction and accelerated atherosclerosis
    Sarah L Ullevig
    Department of Biochemistry, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, United States
    Atherosclerosis 219:409-16. 2011
    ..In this study, we examined the therapeutic potential of the phytonutrients ursolic acid (UA) and resveratrol (RES) in preventing monocyte recruitment and accelerated atherosclerosis...
  48. ncbi Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36
    Yasutaka Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Immunol 178:4854-64. 2007
    ....
  49. ncbi Celastrol inhibits the growth of human glioma xenografts in nude mice through suppressing VEGFR expression
    Yulun Huang
    Department of Neurosurgery, The First Affiliated Hospital of Suzhou University, Suzhou, China
    Cancer Lett 264:101-6. 2008
    ..These findings suggest that celastrol have potential to be used as an antiangiogenesis drug through its role in suppressing VEGF receptors expression that might consequently reduce the signal transduction between VEGF and VEGFR...
  50. pmc Dual targeting of the cyclin/Rb/E2F and mitochondrial pathways in mantle cell lymphoma with the translation inhibitor silvestrol
    Lapo Alinari
    Department of Internal Medicine, College of Medicine, College of Pharmacy, The Ohio State University, Columbus, OH 43210, USA
    Clin Cancer Res 18:4600-11. 2012
    ..We hypothesized that this dual activity of silvestrol would make it especially effective in malignancies driven by aberrant cyclin D1 expression...
  51. ncbi The role of astragaloside in regeneration of the peripheral nerve system
    Chun Yuan Cheng
    Division of Neurosurgery, Changhua Christian Hospital, Changhua, Taiwan
    J Biomed Mater Res A 76:463-9. 2006
    ..Thus, astragaloside plays a dual role in anastomosis, being salutary in aiding the growth of axons in peripheral nerve but also detrimental, terminating the nerve regenerative processes if improperly applied...
  52. ncbi Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells
    Yanting Zhang
    Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou, China
    Acta Biochim Biophys Sin (Shanghai) 43:556-67. 2011
    ..These findings indicate that CuB induces rapid depletion of the G-actin pool through ROS-dependent actin aggregation in melanoma cells, which may at least partly account for its anti-tumor activity...
  53. pmc Retigeric acid B exhibits antitumor activity through suppression of nuclear factor-κB signaling in prostate cancer cells in vitro and in vivo
    Yong qing Liu
    Department of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China
    PLoS ONE 7:e38000. 2012
    ..Therefore, our findings suggested that RB exerted its anti-tumor effect by targeting the NF-κB pathway in PCa cells, and this could be a general mechanism for the anti-tumor effect of RB in other types of cancers as well...
  54. ncbi Targeting mitochondrial apoptosis by betulinic acid in human cancers
    Simone Fulda
    University Children s Hospital, Eythstr 24, D 89075 Ulm, Germany
    Drug Discov Today 14:885-90. 2009
    ..Thus, mitochondrion-targeted agents such as BA hold great promise as a novel approach to overcome certain forms of drug resistance in human cancers...
  55. ncbi Ursolic acid, a potential PPARγ agonist, suppresses ovalbumin-induced airway inflammation and Penh by down-regulating IL-5, IL-13, and IL-17 in a mouse model of allergic asthma
    Seung Hyung Kim
    Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Republic of Korea
    Eur J Pharmacol 701:131-43. 2013
    ....
  56. ncbi Inhibition of pancreatic cancer cell growth by cucurbitacin B through modulation of signal transducer and activator of transcription 3 signaling
    Meixia Zhang
    Department of Clinical Pharmacology, China Medical University, 92 Bei er Rd, Shenyang 110001, China
    Pancreas 39:923-9. 2010
    ..Cucurbitacin B (CuB) is a member of the triterpenoid family and has shown inhibitory effect on various cancer cells. In this study, we have assessed the effect of CuB on pancreatic cancer cells...
  57. ncbi Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells
    Guo Sheng Wu
    State Key Laboratory of Quality Research in Chinese Medicine University of Macau, Macao, PR China
    Fitoterapia 83:408-14. 2012
    ..These results have advanced our current understandings of the anti-cancer mechanisms of GADM...
  58. ncbi De novo sequencing and analysis of the termite mushroom (Termitomyces albuminosus) transcriptome to discover putative genes involved in bioactive component biosynthesis
    Fang Yang
    School of Life Science, Yunnan Normal University, Kunming 650500, China
    J Biosci Bioeng 114:228-31. 2012
    ..Based on the bioinformatic analysis, we found many the known enzymes involved in the biosynthesis of triterpene saponin in Termitomyces albuminosus, including 6 cytochrome P450 and 22 glycosyltransferase unique genes...
  59. ncbi Celastrol suppresses IFN-gamma-induced ICAM-1 expression and subsequent monocyte adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells
    Won Yong Seo
    Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chunchon 200 702, Republic of Korea
    Biochem Biophys Res Commun 398:140-5. 2010
    ..These results suggest that celastrol may exert anti-inflammatory responses by suppressing IFN-gamma-induced expression of ICAM-1 and subsequent monocyte adhesion via expression of HO-1 in the keratinocytes...
  60. ncbi Proliferative inhibition, cell-cycle dysregulation, and induction of apoptosis by ursolic acid in human non-small cell lung cancer A549 cells
    Ya Ling Hsu
    Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No 100, Shin Chuan 1st Road, 807, Taiwan
    Life Sci 75:2303-16. 2004
    ..Taken together, our study indicated that UA might be a potential chemopreventive agent for lung cancer...
  61. ncbi Cranberry phytochemicals: Isolation, structure elucidation, and their antiproliferative and antioxidant activities
    Xiangjiu He
    Department of Food Science, Stocking Hall, Cornell University, Ithaca, New York 14853 7201, USA
    J Agric Food Chem 54:7069-74. 2006
    ..These results showed cranberry phytochemical extracts have potent antioxidant and antiproliferative activities...
  62. ncbi A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation
    Yen Ling Yu
    Vaccine Research and Development Center, National Health Research Institutes, Miaoli, Taiwan
    Eur J Immunol 39:2482-91. 2009
    ..This suggests that me-AntK can potentially be applied to enhance immune responses and modulate DC function in immunotherapy...
  63. ncbi Inhibitors of translation initiation as cancer therapeutics
    Lisa Lindqvist
    Department of Biochemistry, McIntyre Medical Sciences Building, Room 810, 3655 Promenade Sir William Osler, McGill University, Montreal, QC, H3G 1Y6, Canada
    Future Med Chem 1:1709-22. 2009
    ..Small-molecule inhibitors of translation initiation are validating the idea that protein synthesis is a legitimate target for curtailing tumor growth...
  64. ncbi Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes
    Anna Kurek
    Department of Bacterial Genetics, Institute of Microbiology, University of Warsaw, Miecznikowa 1, 02 096 Warsaw, Poland
    Antonie Van Leeuwenhoek 97:61-8. 2010
    ..These results suggest that peptidoglycan metabolism is a cellular target of oleanolic and ursolic acids...
  65. ncbi Antioxidant activity and toxicity profile of total triterpenes isolated from Ganoderma lucidum (Fr.) P. Karst occurring in South India
    T P Smina
    Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala 680555, India
    Environ Toxicol Pharmacol 32:438-46. 2011
    ..Total triterpenes successfully scavenged DPPH(+), ABTS(+) and superoxide radicals, showed significant ferric reducing activity ..
  66. ncbi Ursolic acid-induced AMP-activated protein kinase (AMPK) activation contributes to growth inhibition and apoptosis in human bladder cancer T24 cells
    Qing You Zheng
    Department of Urology, the Military General Hospital of Beijing PLA, Beijing 100700, China
    Biochem Biophys Res Commun 419:741-7. 2012
    ..Our study suggests that activation of AMPK by UA contributes to growth inhibition and apoptosis in human bladder cancer cells...
  67. ncbi Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro
    Wei Dong Zhang
    Department of Natural Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai, P R China
    Planta Med 72:4-8. 2006
    ..These data suggest the potential roles of antioxidative and nitric oxide-inducing properties of astragaloside IV in its protection from myocardial ischemia...
  68. pmc Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite
    Didik Priyandoko
    National Institute of Advanced Industrial Science and Technology, Tsukuba, Ibaraki, Japan
    PLoS ONE 6:e19552. 2011
    ..These findings warrant further basic and clinical studies that may promote the use of withanone as a health adjuvant in a variety of consumer products where the toxicity has been a concern because of the use of ester phthalates...
  69. ncbi Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia
    Yumin Luo
    Institute of Neurology, Fudan University Huashan Hospital, Shanghai 200040, PR China
    Neurosci Lett 363:218-23. 2004
    ..We suggest that the anti-infarction effect by Astragaloside IV may be derived at least in part from its antioxidant properties...
  70. pmc Maslinic acid potentiates the anti-tumor activity of tumor necrosis factor alpha by inhibiting NF-kappaB signaling pathway
    Chenghai Li
    The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai 200241, China
    Mol Cancer 9:73. 2010
    ..The aim of this study was to determine whether MA potentiates the anti-tumor activity of TNFalpha though the regulation of NF-kappaB activation...
  71. ncbi Celastrol inhibits the growth of estrogen positive human breast cancer cells through modulation of estrogen receptor α
    Soon Young Jang
    School of Life Sciences and Biotechnology, Korea University, Seoul 136 701, South Korea
    Cancer Lett 300:57-65. 2011
    ....
  72. ncbi Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
    Wen bo Wang
    Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
    J Cell Physiol 227:2196-206. 2012
    ..The potency of celastrol to induce paraptosis, apoptosis and autophagy at the same dose might be related to its capability to affect a variety of pathways including proteasome, ER stress and Hsp90...
  73. ncbi Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos
    Takashi Kikuchi
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 74:137-44. 2011
    ..Furthermore, poricotriol A was shown to possess high selective toxicity in lung cancer cells since it exhibited only weak cytotoxicity against a normal lung cell line (WI-38)...
  74. ncbi Antiangiogenic activity of Tripterygium wilfordii and its terpenoids
    Ming Fang He
    Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, PR China
    J Ethnopharmacol 121:61-8. 2009
    ..Tripterygium wilfordii Hook. f. (Celastraceae) has been traditionally used as folk medicine for centuries in China for the treatment of immune-inflammatory diseases...
  75. ncbi Molecular cloning and functional expression of triterpene synthases from pea (Pisum sativum) new alpha-amyrin-producing enzyme is a multifunctional triterpene synthase
    M Morita
    Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Eur J Biochem 267:3453-60. 2000
    ..Pisum sativum is known to produce both types of triterpenes. Homology based PCRs with degenerate primers designed from the conserved sequences found in the known beta-..
  76. ncbi Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase
    Xiao Le Xu
    Department of Pharmacology, China Pharmaceutical University, Nanjing, PR China
    Pharmacology 81:325-32. 2008
    ..These results suggest that the beneficial effect of astragaloside IV in H/R-induced injury may be related to normalization of SR Ca2+ pump expression and, thus, may prevent the depression in SR Ca2+ handling...
  77. pmc Preclinical studies of celastrol and acetyl isogambogic acid in melanoma
    Sabiha Abbas
    Signal Transduction Program, Cancer Center, Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Clin Cancer Res 13:6769-78. 2007
    ..Sensitize melanomas to apoptosis and inhibit their growth and metastatic potential by compounds that mimic the activities of activating transcription factor 2 (ATF2)-driven peptides...
  78. ncbi Effect of betulinic acid on anticancer drug-resistant colon cancer cells
    Gwon Ryul Jung
    Department of Pharmacology, College of Medicine, Chosun University, 488 Seosuk dong, Dong Gu, Gwangju 501 140, Korea
    Basic Clin Pharmacol Toxicol 101:277-85. 2007
    ..These findings indicate that the use of BetA as a chemosensitizer may be a new strategy to enhance the efficacy of chemotherapy. However, further studies will be needed for confirmation...
  79. ncbi Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model
    Muthu K Shanmugam
    Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597
    Int J Cancer 129:1552-63. 2011
    ..Overall, our experimental findings suggest that UA exerts its antimetastatic effects through the suppression of CXCR4 expression in prostate cancer both in vitro and in vivo...
  80. pmc Genomic and coexpression analyses predict multiple genes involved in triterpene saponin biosynthesis in Medicago truncatula
    Marina A Naoumkina
    Plant Biology Division, Samuel Roberts Noble Foundation, Ardmore, Oklahoma 73401, USA
    Plant Cell 22:850-66. 2010
    ..This report provides a basis for future studies to define genetically the roles of multiple cytochromes P450 and glycosyltransferases in triterpene saponin biosynthesis in Medicago...
  81. pmc Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells
    Florence W K Cheung
    School of Chinese Medicine, Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
    Mar Drugs 8:80-90. 2010
    ..Our results provide a better understanding of the apoptotic properties and chemotherapeutical potential of this marine triterpene...
  82. ncbi Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    Anita Thyagarajan
    Methodist Research Institute, Indianapolis, Indiana, USA
    Nutr Cancer 62:630-40. 2010
    ..Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer...
  83. ncbi Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease
    A C Allison
    SurroMed Corporation, Palo Alto, CA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1341-57. 2001
    ..The potent antioxidant and anti-inflammatory activities of celastrol, and its effects on cognitive functions, suggest that the drug may be useful to treat neurodegenerative diseases accompanied by inflammation, such as AD...
  84. ncbi Quantitative determination for cytotoxic Friedo-nor-oleanane derivatives from five morphological types of Maytenus ilicifolia (Celastraceae) by reverse-phase high-performance liquid chromatography
    Waldemar Buffa Filho
    Núcleo de Bioensaio, Biossíntese e Ecofisiologia de Produtos Naturais, Instituto de Quimica, Universidade Estadual Paulista, CP 355, 14801 970, Araraquara SP, Brazil
    Phytochem Anal 13:75-8. 2002
    ..Well resolved peaks with good detection response and linearity in the range 1.0-100 micrograms/mL were obtained...
  85. ncbi Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina
    Sumonthip Kongtun
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand
    Planta Med 75:839-42. 2009
    ..In addition to bryonolic acid (1), bryononic acid (2), cucurbitacin B (3), and dihydrocucurbitacin B (4) also were isolated from the root extract...
  86. ncbi Cucurbitacin B induces G2 arrest and apoptosis via a reactive oxygen species-dependent mechanism in human colon adenocarcinoma SW480 cells
    Shusuke Yasuda
    Department of Molecular Targeting Cancer Prevention, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto, Japan
    Mol Nutr Food Res 54:559-65. 2010
    ..These results suggested that cucB induced G(2) arrest and apoptosis through a STAT3-independent but ROS-dependent mechanism in SW480 cells...
  87. pmc Bioactive sesterterpenes and triterpenes from marine sponges: occurrence and pharmacological significance
    Sherif S Ebada
    Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Duesseldorf, Germany
    Mar Drugs 8:313-46. 2010
    ..In this review, we survey sesterterpenoids and triterpenoids obtained from marine sponges and highlight their bioactivities...
  88. ncbi Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression
    Wei Jian Zhang
    Department of Vascular Biology and Thrombosis Research, University of Vienna, Austria
    Thromb Haemost 90:904-14. 2003
    ..We conclude that the ability of AS-IV to inhibit the NF-kappaB pathway might be one under-lying mechanism contributing to its anti-inflammatory potential in vivo...
  89. ncbi Cucurbitacin E as a new inhibitor of cofilin phosphorylation in human leukemia U937 cells
    Souichi Nakashima
    Department of Pharmacognosy, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, Kyoto 607 8412, Japan
    Bioorg Med Chem Lett 20:2994-7. 2010
    Cucurbitane-type triterpenes, cucurbitacins B and E, were reported to exhibit cytotoxic effects in several cell lines mediated by JAK/STAT3 signaling...
  90. pmc Isolation of an Arabidopsis thaliana gene encoding cycloartenol synthase by functional expression in a yeast mutant lacking lanosterol synthase by the use of a chromatographic screen
    E J Corey
    Department of Chemistry, Harvard University, Cambridge, MA 02138
    Proc Natl Acad Sci U S A 90:11628-32. 1993
    ..4.99.-) from Bacillus acidocalcarius. The method used to clone this gene should be generally applicable to genes responsible for secondary metabolite biosynthesis...
  91. ncbi Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    Jiazhi Sun
    Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
    Oncogene 24:3236-45. 2005
    ..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition...
  92. pmc The relevance of higher plants in lead compound discovery programs
    A Douglas Kinghorn
    Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA
    J Nat Prod 74:1539-55. 2011
    ..In this review, progress made in the senior author's laboratory in research work on naturally occurring sweeteners and other taste-modifying substances and on potential anticancer agents from tropical plants will be described...
  93. ncbi Betulinic acid inhibits prostate cancer growth through inhibition of specificity protein transcription factors
    Sudhakar Chintharlapalli
    Institute of Biosciences and Technology, Texas A and M University Health Science Center, Houston, Texas 77843 4466, USA
    Cancer Res 67:2816-23. 2007
    ..Thus, betulinic acid acts as a novel anticancer agent through targeted degradation of Sp proteins that are highly overexpressed in tumors...
  94. ncbi Acidic triterpenes compromise growth and survival of astrocytoma cell lines by regulating reactive oxygen species accumulation
    Ruben Martin
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas Universidad de Valladolid, C Sanz y Fores s n, 47003 Valladolid, Spain
    Cancer Res 67:3741-51. 2007
    Several studies have shown how pentacyclic triterpenes can inhibit proliferation and induce apoptosis of some tumor cell lines; however, its effect on astrocytic tumors, one of the most malignant forms of cancer, has rarely been reported...
  95. ncbi Evaluation of the effect of triterpenes on urinary risk factors of stone formation in pyridoxine deficient hyperoxaluric rats
    Lakshminarasimhan Vidya
    Department of Medical Biochemistry, Dr A L M Post Graduate Institute of Basic Medical Sciences, Taramani, Chennai 600 113, India
    Phytother Res 16:514-8. 2002
    ..Treatment with lupeol and lupeol linoleate reduced the extent of tubular damage as evidenced from reduced enzymuria and minimized the excretion of stone forming constituents...
  96. pmc Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis
    Yong Gao
    Department of Oncology, Shanghai Tongji University Affiliated East Hospital, Shanghai
    Cancer Res 71:5182-93. 2011
    ..Overall, our findings argue that Sp1 is an important target of BA and MIT and that their combination can produce an enhanced therapeutic response in human pancreatic cancer...
  97. ncbi Antihyperglycemic effects of gymnemic acid IV, a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice
    Y Sugihara
    Department of Chemical Pharmacology, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    J Asian Nat Prod Res 2:321-7. 2000
    ..These results indicate that insulin-releasing action of gymnemic acid IV may contribute to the antihyperglycemic effect by the leaves of G. sylvestre. Gymnemic acid IV may be an anti-obese and antihyperglycemic pro-drug...
  98. pmc Reduction of beta-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
    Daniel Paris
    The Roskamp Institute, 2040 Whitfield Avenue, Sarasota, FL 34243, USA
    J Neuroinflammation 7:17. 2010
    ..We therefore explored whether the known NFkappaB inhibitor celastrol could represent a suitable compound for decreasing Abeta production and accumulation in vivo...
  99. ncbi Inhibition of IkappaB kinase activity by acetyl-boswellic acids promotes apoptosis in androgen-independent PC-3 prostate cancer cells in vitro and in vivo
    Tatiana Syrovets
    Department of Pharmacology of Natural Products and Clinical Pharmacology and Department of Urology, University of Ulm, Helmholtzstrasse 20, D 89081 Ulm, Germany
    J Biol Chem 280:6170-80. 2005
    ..Thus, AKbetaBA and related compounds acting on IKK might provide a novel approach for the treatment of chemoresistant human tumors such as androgen-independent human prostate cancers...
  100. pmc Saponin biosynthesis in Saponaria vaccaria. cDNAs encoding beta-amyrin synthase and a triterpene carboxylic acid glucosyltransferase
    Dauenpen Meesapyodsuk
    Plant Biotechnology Institute, Saskatoon, Saskatchewan, Canada S7N OW9
    Plant Physiol 143:959-69. 2007
    ..UGT74M1 is expressed in roots and leaves and appears to be involved in monodesmoside biosynthesis in S. vaccaria...
  101. ncbi A novel Hsp90 inhibitor to disrupt Hsp90/Cdc37 complex against pancreatic cancer cells
    Tao Zhang
    Division of Pharmaceutics, College of Pharmacy, The Ohio State University, 500 West 12th Avenue, Columbus, OH 43210, USA
    Mol Cancer Ther 7:162-70. 2008
    ..The data suggest that celastrol is a novel Hsp90 inhibitor to disrupt Hsp90-Cdc37 interaction against pancreatic cancer cells...

Research Grants33

  1. Modified Triterpines as Potent HIV Fusion Inhibitors
    Kuo Hsiung Lee; Fiscal Year: 2012
    ..and the first-in-class HIV maturation inhibitor, we have also discovered that appropriately substituted triterpenes show potent HIV entry inhibition...
  2. Anti-Promoting Effects of Triterpenes Alone or Combined with Other Phytochemicals
    Thomas J Slaga; Fiscal Year: 2013
    ..We have made significant progress in the synthesis/preparation of additional pentacyclic triterpenes found in P. frutescens...
  3. Effect of Mushroom Extracts on Prostate Cancer
    Joel Slaton; Fiscal Year: 2003
    ..Ganoderma Lucidum (Reishi) contain a number of bioactive compounds including triterpenes which can down-regulate MMP-9, a member of the matrix metalloprotease (MMP) family of genes...
  4. ENANTIOSELECTIVE SYNTHESIS OF NATURAL PRODUCTS
    Mark Wentland; Fiscal Year: 2000
    ..We will begin an enantioselective total synthesis of (+)-quassin, a member of the quassinoid family of triterpenes of interest because of their wide spectrum of biological properties, including antileukemic activity...
  5. NATURAL PRODUCT DERIVATIVES THAT POTENTLY INHIBIT HIV1
    Graham Allaway; Fiscal Year: 1999
    ..A) Three related coumarins: Di-Camphanoyl-Khallactone (DCK), 4-methyl DCK and thiolactone DCK; B) Three related triterpenes: Dimethylsuccinylbetulinic acid (DSB), Dimethylsuccinyldihydrobetulinic acid (DSD) and Dimethylglutarylbetulin (..
  6. Beta-amyloid 1-42 lowering agent for Alzheimer's Disease
    MARK FINDEIS; Fiscal Year: 2006
    ..Preliminary data suggest that the AB42 lowering activity is separate from the triterpenes associated with the conventional use of this extract...
  7. Baylis-Hillman/Aldol Cyclization in Synthesis of QS-21
    Reema Thalji; Fiscal Year: 2006
    ..In addition to contributing to the limited literature on the synthesis of the structurally complex pentacyclic triterpenes, a total synthesis of this important molecule would provide sufficient material necessary for extensive ..
  8. Anticancer Potential of Black Cohosh on Breast Cancer
    LINDA EINBOND; Fiscal Year: 2007
    ..This research project could identify new approaches to breast cancer prevention and therapy. ..
  9. Lupeol, A Novel Fuit and Vegetable Based Triterpene for Prostate Cancer
    MOHAMMAD SALEEM BHAT; Fiscal Year: 2008
    ..We believe that this application will be extremely valuable in providing a novel fruit and vegetable based agent for chemoprevention and possibly for treating prostate cancer [unreadable] [unreadable] [unreadable]..
  10. New Orally Active Agents for Cancer Prevention
    Tadashi Honda; Fiscal Year: 2004
    ..abstract_text> ..
  11. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  12. GLYCOCONJUGATES IN VIRAL PATHOGENESIS
    GILLIAN AIR; Fiscal Year: 2007
    ..abstract_text> ..
  13. Regulation of HSF1 and HSF2 by SUMO-1 Modification
    KEVIN SARGE; Fiscal Year: 2007
    ..abstract_text> ..
  14. A Novel Inhibitor of Stat3 for Prostate Cancer Therapy
    Naijie Jing; Fiscal Year: 2009
    ..abstract_text> ..
  15. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  16. Combined Natural Inhibitors in Skin Cancer Prevention
    THOMAS SLAGA; Fiscal Year: 2007
    ..abstract_text> ..
  17. Therapeutic effect of boswellin in prostate cancer
    Yongkui Jing; Fiscal Year: 2005
    ..We hope our proposal will lead to the discovery of a novel complementary agent for prostate cancer treatment. ..
  18. Molecular Genetics of the Cytoskeleton
    David Knecht; Fiscal Year: 2009
    ..The structure of the actin binding domains of each of these proteins will also be determined to investigate the mechanism by which they differentially recognize actin filaments. ..
  19. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  20. REGULATION OF PROTEIN PHOSPHATASE 2A BY CELLULAR PROTEIN
    KEVIN SARGE; Fiscal Year: 2004
    ..This knowledge could aid understanding of both normal cell growth regulation as well as aberrant proliferation control in cancer cells. ..
  21. DEVELOPING A POTENT INHIBITOR OF HIV-I INTEGRASE
    Naijie Jing; Fiscal Year: 2001
    ....
  22. GR Impairment in Carconogenesis: Tumor Suppressor Role
    THOMAS SLAGA; Fiscal Year: 2009
    ..4) To analyze the effects of dissociated glucocorticoids on skin inflammation, keratinocyte proliferation, and on skin tumor development. ..
  23. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  24. Pneumocystis Biochemistry: Ubiquinones
    EDNA KANESHIRO; Fiscal Year: 2002
    ..carinii CoQ biosynthesis and growth in axenic cultures, and (4) develop atovaquone-resistant P. carinii populations to evaluate CoQ synthesis in sensitive and resistant organisms. ..
  25. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  26. Effect of Pokeweed antiviral protein on hepatitis C virus IRES
    Rong Di; Fiscal Year: 2007
    ..This study will lay the groundwork for designing novel drugs against HCV for the treatment of chronic hepatitis. [unreadable] [unreadable]..
  27. 2D-HPLC-Tandem Mass Spectrometer for Proteomics
    Richard van Breemen; Fiscal Year: 2005
    ..Overall, the proposed 2D mu LC-MS/MS instrument will complement the existing proteomics resources on campus and will enhance the current research of NIH-funded users by providing analytical capabilities currently unavailable on campus. ..
  28. Mechanisms of prostate cancer prevention by lycopene
    Richard van Breemen; Fiscal Year: 2007
    ..These human studies will provide vital information for the design of future clinical trials investigating the chemoprevention of prostate cancer by lycopene. [unreadable] [unreadable] [unreadable]..
  29. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  30. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  31. The Bioavilaibility of Folate in Humans
    Richard van Breemen; Fiscal Year: 2004
    ..Our new LC-MS-MS assay and the use of 13C-labeled folate species will provide new and more detailed information on the uptake, metabolism, and bioavailability of folates than has been possible previously. ..
  32. HPLC time-of-flight mass spectrometer for accurate mass measurements
    Richard van Breemen; Fiscal Year: 2007
    ..to natural product chemists and synthetic organic chemists in the user community who rely upon rapid analyses of their compounds in order to advance with their NIH-funded research programs [unreadable] [unreadable] [unreadable]..
  33. MATRIX-ASSISTED LASER DESORPTION TOF MASS SPECTROMETER
    Richard van Breemen; Fiscal Year: 2001
    ..abstract_text> ..