sesquiterpenes

Summary

Top Publications

  1. ncbi Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    Dae Kyun Ro
    California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 440:940-3. 2006
  2. ncbi Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
    Kohki Akiyama
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Nature 435:824-7. 2005
  3. ncbi Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    M B Reed
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nature 403:906-9. 2000
  4. ncbi Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
  5. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
  6. pmc Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 298:210-3. 2002
  7. ncbi Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp
    Hou Jin Li
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Chem Biodivers 8:317-24. 2011
  8. ncbi Recruitment of entomopathogenic nematodes by insect-damaged maize roots
    Sergio Rasmann
    University of Neuchatel, Institute of Zoology, Laboratory of Animal Ecology and Entomology, CP 2, CH 2007 Neuchatel, Switzerland
    Nature 434:732-7. 2005
  9. pmc A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis
    Dongtao Ren
    State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
    Proc Natl Acad Sci U S A 105:5638-43. 2008
  10. ncbi Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
    Mingji Xian
    Department of Internal Medicine, Division of Hematology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku Tokyo, 160 8582 Japan
    Cancer Sci 98:118-26. 2007

Research Grants

  1. The Fulvene Approach to the Syntheses of Antitumor Agents
    Ihsan Erden; Fiscal Year: 2013
  2. Tools to Fight Cancer: Exploiting Heck-type Olefinations to Forge Medium Rings
    Jennifer L Roizen; Fiscal Year: 2012
  3. NEW CATALYSTS FOR ASYMMETRIC DIELS-ALDER REACTIONS
    Peter Mackenzie; Fiscal Year: 1991
  4. Enantioselective Synthesis of Halogenated Chamigrenes
    JEREMY MORGAN; Fiscal Year: 2006
  5. BRIDGEHEAD INTERMEDIATES IN SYNTHESIS
    George Kraus; Fiscal Year: 1991
  6. SYNTHETIC STUDIES OF CYTOTOXIC NATURAL PRODUCTS
    FREDERICK ZIEGLER; Fiscal Year: 1980
  7. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
  8. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
  9. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  10. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005

Detail Information

Publications317 found, 100 shown here

  1. ncbi Production of the antimalarial drug precursor artemisinic acid in engineered yeast
    Dae Kyun Ro
    California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
    Nature 440:940-3. 2006
    ..annua, yield optimization and industrial scale-up will be required to raise artemisinic acid production to a level high enough to reduce artemisinin combination therapies to significantly below their current prices...
  2. ncbi Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
    Kohki Akiyama
    Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    Nature 435:824-7. 2005
    ..The natural strigolactones 5-deoxy-strigol, sorgolactone and strigol, and a synthetic analogue, GR24, induced extensive hyphal branching in germinating spores of the AM fungus Gigaspora margarita at very low concentrations...
  3. ncbi Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
    M B Reed
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
    Nature 403:906-9. 2000
    ..This has important implications for the development and efficacy of future antimalarial agents...
  4. ncbi Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
    ..Although a slight inhibition of IkappaB degradation was detected for all SLs, the amount of remaining IkappaB was too low to explain the observed NF-kappaB inhibition...
  5. ncbi Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
    Arjen Dondorp
    Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
    Lancet 366:717-25. 2005
    ..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
  6. pmc Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Science 298:210-3. 2002
    ..pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria...
  7. ncbi Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp
    Hou Jin Li
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
    Chem Biodivers 8:317-24. 2011
    ..The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines...
  8. ncbi Recruitment of entomopathogenic nematodes by insect-damaged maize roots
    Sergio Rasmann
    University of Neuchatel, Institute of Zoology, Laboratory of Animal Ecology and Entomology, CP 2, CH 2007 Neuchatel, Switzerland
    Nature 434:732-7. 2005
    ..Development of new varieties that release the attractant in adequate amounts should help enhance the efficacy of nematodes as biological control agents against root pests like D. v. virgifera...
  9. pmc A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis
    Dongtao Ren
    State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
    Proc Natl Acad Sci U S A 105:5638-43. 2008
    ..These results indicate that the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection...
  10. ncbi Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
    Mingji Xian
    Department of Internal Medicine, Division of Hematology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku Tokyo, 160 8582 Japan
    Cancer Sci 98:118-26. 2007
    ..Taken together, ZER is an inducer of apoptosis in leukemic cells that specifically triggers the Fas/CD95- and mitochondria-mediated apoptotic signaling pathway...
  11. ncbi Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering
    Mohammad A Asadollahi
    Center for Microbial Biotechnology CMB, Department of Systems Biology, Building 223, Technical University of Denmark DTU, DK 2800 Kgs Lyngby, Denmark
    Metab Eng 11:328-34. 2009
    A genome-scale metabolic model was used to identify new target genes for enhanced biosynthesis of sesquiterpenes in the yeast Saccharomyces cerevisiae. The effect of gene deletions on the flux distributions in the metabolic model of S...
  12. pmc Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
    Asaph Aharoni
    Plant Research International, 6700 AA, Wageningen, The Netherlands
    Plant Cell 15:2866-84. 2003
    ..Most of the volatiles detected were monoterpenes and sesquiterpenes, which in contrast to other volatiles showed a diurnal emission pattern...
  13. ncbi Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    Ric N Price
    Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
    Lancet 364:438-47. 2004
    ..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
  14. ncbi Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase
    X Li
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    Cell Mol Life Sci 62:894-904. 2005
    ....
  15. ncbi (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
    Petra Schneider
    Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Int J Parasitol 36:403-8. 2006
    ..Our data suggest that the potential of malaria transmission remains high even after treatment with artemisinin combination therapy, although prevalence and density of gametocytes is lower after SP+AS...
  16. ncbi What made sesquiterpene lactones reach cancer clinical trials?
    Akram Ghantous
    Biology Department, American University of Beirut, Beirut, Lebanon
    Drug Discov Today 15:668-78. 2010
    ..These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them lead compounds in cancer clinical trials...
  17. pmc Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233
    Bin Wu
    Ocean College, Zhejiang University, Hangzhou 310058, China
    Mar Drugs 11:2713-21. 2013
    Two new sesquiterpenes, 1β,5α,6α,14-tetraacetoxy-9α-benzoyloxy-7β H-eudesman-2β,11-diol (1) and 4α,5α-diacetoxy-9α-benzoyloxy-7βH-eudesman-1β,2β,11, 14-tetraol (2), were produced as stress metabolites ..
  18. ncbi Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
    Susan J Zunino
    United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
    Cancer Lett 254:119-27. 2007
    ..Parthenolide-induced elevation of hypochlorite anion was observed only in the two t(4;11) lines. These data suggest parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs...
  19. ncbi Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells
    Siyuan Zhang
    Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, Singapore 117597
    Cancer Lett 208:143-53. 2004
    ..These data clearly demonstrate that the intracellular thiols and calcium equilibrium play a critical role in parthenolide-induced apoptotic cell death...
  20. pmc Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells
    Muhammad Khan
    Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, PR China
    Int J Biol Sci 8:533-47. 2012
    ..Therefore, isoalantolactone may be a safe chemotherapeutic candidate for the treatment of human pancreatic carcinoma...
  21. ncbi Artemisinin: mechanisms of action, resistance and toxicity
    Steven R Meshnick
    Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill 27599 7435, USA
    Int J Parasitol 32:1655-60. 2002
    ..At high doses, artemisinin can be neurotoxic but toxicity has not been found in clinical studies. The mechanism of neurotoxicity may be similar to the mechanism of action...
  22. ncbi Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death
    G Wang
    The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
    Cell Mol Life Sci 62:881-93. 2005
    ..These data indicate that the effect of beta-elemene on lung cancer cell death may be through a mitochondrial release of the cytochrome c-mediated apoptotic pathway...
  23. ncbi Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms
    Siyuan Zhang
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Republic of Singapore
    Curr Med Chem Anticancer Agents 5:239-49. 2005
    ..Taken together, many SLs are emerging as promising anti-cancer agents with potential applications in both cancer chemotherapy and chemoprevention...
  24. ncbi Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide
    Jing Wen
    Division of Gastroenterology and Hepatology, Departments of Internal Medicine and Anatomy Research Institute for Clinical Medicine, Chonbuk National University Medical School and Hospital, Chonju, Chonbuk 561 712, Republic of Korea
    J Biol Chem 277:38954-64. 2002
    ..Finally, parthenolide and its derivatives may be useful chemotherapeutic agents to treat these invasive cancers...
  25. ncbi Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
    Yasunari Takada
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
    Oncogene 24:6957-69. 2005
    ....
  26. ncbi Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells
    Bokyung Sung
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 68:8938-44. 2008
    ..Overall, our results show that zerumbone is a novel inhibitor of CXCR4 expression and thus has a potential in the suppression of cancer metastasis...
  27. ncbi Phytoalexin transgenics in crop protection--fairy tale with a happy end?
    Dominik K Großkinsky
    Institute of Plant Sciences, Department of Plant Physiology, University of Graz, Schubertstraße 51, 8010 Graz, Austria
    Plant Sci 195:54-70. 2012
    ..Based on this, the advantages as well as potential bottlenecks for molecular approaches of modulating inducible phytoalexins to improve crop protection are discussed...
  28. ncbi Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS
    Mazen Kurdi
    The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
    J Cell Physiol 212:424-31. 2007
    ..The finding that signaling by the IL-6-type cytokine may be redox-sensitive defines a novel mechanism of regulation that has implications for exploiting their therapeutic potential...
  29. ncbi Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats
    Ying Chao Lin
    Division of Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Taichung Branch, Taiwan
    Behav Pharmacol 22:739-50. 2011
    ..Collectively, our results indicate that lemnalol is a potential therapeutic agent for neuropathic pain, and that further exploration of the effects of lemnalol on glial proinflammatory responses is warranted...
  30. ncbi Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
    Zhi Fei Wang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
    Pharmacol Biochem Behav 83:603-11. 2006
    ..It also indicates that the MAPK/ERK pathway might be involved in the in vivo neurotrophic effects of huperzine A against transient cerebral ischemia and reperfusion...
  31. pmc Lochmolins A-G, new sesquiterpenoids from the soft coral Sinularia lochmodes
    Yen Ju Tseng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 10:1572-81. 2012
    ..The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1-4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells...
  32. ncbi The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes
    Ai Xia Cheng
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
    Phytochemistry 68:1632-41. 2007
    ..In vitro, the recombinant protein of OsTPS3 catalyzed formation of (E)-beta-caryophyllene and several other sesquiterpenes, including beta-elemene and alpha-humulene, all being components of inducible volatiles of rice plants...
  33. ncbi In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma
    Jinshun Zhao
    Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
    Int J Oncol 31:241-52. 2007
    ..Finally, the beta-elemene-induced alteration of cell membrane permeability, which has potential to result in enhanced cellular uptake of taxanes, may also contribute to the synergistic interactions of the combination treatments...
  34. ncbi Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction
    Azhar Rasul
    Dental Hospital, Jilin University, Changchun 130041, China
    Molecules 18:1418-33. 2013
    ..These findings provide the rationale for further in vivo and clinical investigation of costunolide against human bladder cancer...
  35. ncbi Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation
    Yi Qun Yao
    Department of Neurosurgery, 1st Affiliated Hospital of Dalian Medical University, Dalian, China
    Cancer Lett 264:127-34. 2008
    ..Taken together, our findings indicate that activation of p38 MAPK is critical for the anti-proliferation effect of beta-elemene and that p38 MAPK might be a putative pharmacological target for glioblastoma therapy...
  36. ncbi Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation
    Daniela Carlisi
    Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Scienze Biochimiche, Universita di Palermo, Policlinico, Palermo, Italy
    J Cell Physiol 226:1632-41. 2011
    ..Our results suggest that co-treatment with parthenolide and TRAIL could represent a new important therapeutic strategy for hepatic tumors...
  37. pmc A phase II trial of huperzine A in mild to moderate Alzheimer disease
    M S Rafii
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 76:1389-94. 2011
    ..Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD)...
  38. ncbi Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
    Thomas Efferth
    German Cancer Research Center, M070, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Curr Drug Targets 7:407-21. 2006
    ..g. the translationally controlled tumor protein (TCTP). Emphasis is given to pharmacogenomic approaches to analyze the pleiotropic nature of mechanisms of artemisinins in cancer cells...
  39. pmc In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling
    John V W Becker
    Biosciences, CSIR, PO Box 395, Pretoria, 0001, South Africa
    Malar J 10:295. 2011
    ..One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile...
  40. ncbi Ylangene-type and nardosinane-type sesquiterpenoids from the soft corals Lemnalia flava and Paralemnalia thyrsoides
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University
    Chem Pharm Bull (Tokyo) 58:381-5. 2010
    ..The structures of metabolites 1 and 4-6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1-7 and 11 was evaluated in vitro...
  41. ncbi The biosynthesis of isoprenoids and the mechanisms regulating it in plants
    Kazunori Okada
    Biotechnology Research Center, The University of Tokyo, Japan
    Biosci Biotechnol Biochem 75:1219-25. 2011
    ....
  42. ncbi Tehranolide molecule modulates the immune response, reduce regulatory T cell and inhibits tumor growth in vivo
    Shokoofe Noori
    Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
    Mol Immunol 47:1579-84. 2010
    ..05) decreased the number of these lymphocytes. These findings show that the use of Tehranolide molecule represents a novel strategy with major suggestions for cancer therapy approaches...
  43. ncbi Enhancement of natural disease resistance in potatoes by chemicals
    Adriana B Andreu
    Instituto de Investigaciones Biologicas, Universidad Nacional de Mar del Plata, Funes 3250, 7600 Mar del Plata, Argentina
    Pest Manag Sci 62:162-70. 2006
    ..This treatment may offer the possibility of controlling both foliage and tuber blight and could have a major impact in reducing over-winter survival of P. infestans in tubers...
  44. ncbi The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes
    John P Fallon
    Medical Mycology Unit, Department of Biology, National Institute for Cellular Biotechnology, National University of Ireland Maynooth, Co Kildare, Ireland
    Microbiology 157:1481-8. 2011
    ..During growth of the fungus in the larvae, this toxin, along with others, may facilitate growth by suppressing the cellular immune response...
  45. pmc The effects of abiotic factors on induced volatile emissions in corn plants
    Sandrine P Gouinguené
    Institute of Zoology, Laboratory of Animal Ecology and Entomology, University of Neuchatel, Case Postale 2, CH 2007 Neuchatel, Switzerland
    Plant Physiol 129:1296-307. 2002
    ..Hence, climatic conditions and nutrient availability can be important factors in determining the intensity and variability in the release of induced plant volatiles...
  46. ncbi Artemisinin-based combinations
    Elizabeth A Ashley
    Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
    Curr Opin Infect Dis 18:531-6. 2005
    ..Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world...
  47. ncbi Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)
    José C Aponte
    Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
    Planta Med 76:705-7. 2010
    ....
  48. ncbi Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells
    Fen Yang
    State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
    J Pharmacol Sci 119:214-20. 2012
    ..These data suggested that hirsutanol A could induce apoptosis and autophagy via accumulation of ROS and co-treatment with an autophagy inhibitor could sensitize MCF-7 cells to hirsutanol A...
  49. pmc Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster
    Qiang Wang
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 287:6159-68. 2012
    ..The implications for the underlying metabolic evolution of plants are then discussed...
  50. ncbi Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells
    Jen Yu Hung
    Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
    Lung Cancer 68:355-65. 2010
    ..This study demonstrates that DHE may be a novel anticancer agent for the treatment of non-small cell lung cancer...
  51. ncbi Metabolic engineering of Escherichia coli for α-farnesene production
    Chonglong Wang
    Division of Applied Life Science BK21 program, EB NCRC and PMBBRC, Gyeongsang National University, Jinju 660 701, Republic of Korea
    Metab Eng 13:648-55. 2011
    b>Sesquiterpenes are important materials in pharmaceuticals and industry. Metabolic engineering has been successfully used to produce these valuable compounds in microbial hosts...
  52. ncbi Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1)
    Sundar Neelakantan
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
    Bioorg Med Chem Lett 19:4346-9. 2009
    ..5-3.0microM). Compounds 16, 24 and 30 were the most potent compounds in the series, causing greater than 90% cell death at 10microM concentration against primary AML cells in culture, with LD(50) values of 1.7, 1.8 and 1.6microM...
  53. ncbi Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions
    Y N Vashisht Gopal
    Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Unit 079, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
    Mol Cancer Ther 8:552-62. 2009
    ..Our study illustrates an alternative approach for controlling MDM2 and p53 activities and identifies an additional critically important cancer pathway affected by PN...
  54. ncbi Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis
    Sang Kyu Lee
    Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 305 764, Republic of Korea
    Biochem Biophys Res Commun 391:1592-7. 2010
    ..Taken together, these all indicate that stabilization and translocation of p53 to mitochondria is involved in Bax translocation to mitochondria in simvastatin-induced apoptosis...
  55. pmc The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells
    Yun Dai
    Division of Hematology Oncology, Department of Medicine, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA
    Br J Haematol 151:70-83. 2010
    ..They also raise the possibility that this strategy may target leukaemic progenitor cells...
  56. ncbi Evaluation of mosquitocidal activity of essential oil and sesquiterpenes from leaves of Chloroxylon swietenia DC
    S Ravi Kiran
    Department of Botany, Osmania University, Hyderabad, 500007, India
    Parasitol Res 101:413-8. 2007
    ..Encouraged by this, the essential oil and the sesquiterpenes isolated from the leaves of Chloroxylon swietenia DC...
  57. ncbi The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
    B H Kwok
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA
    Chem Biol 8:759-66. 2001
    ..In addition, these results may be useful in the development of additional anti-inflammatory agents...
  58. ncbi The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma
    Ellen J Gunn
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Leuk Lymphoma 52:1085-97. 2011
    ..This is the first report of a natural product with anti-CSC activity in myeloma, suggesting that it has the potential to improve the survival of patients with MM by eliminating the relapse-causing MM-CSCs...
  59. ncbi Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
    Yoshimasa Nakamura
    Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
    FEBS Lett 572:245-50. 2004
    ..The present study also implied the antioxidant role of this detoxification system activation by ZER in the neutralization of lipid peroxidation in hepatocytes, providing a new insight for cancer prevention...
  60. ncbi Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice
    M R Sulaiman
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Fitoterapia 81:855-8. 2010
    ..It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test...
  61. pmc Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea
    Cristina Pinedo
    Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cadiz, Puerto Real, Spain
    ACS Chem Biol 3:791-801. 2008
    ..Recombinant BcBOT2 protein converted farnesyl diphosphate to the parent sesquiterpene of the botrydial biosynthetic pathway, the tricyclic alcohol presilphiperfolan-8beta-ol...
  62. pmc NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells
    Jiangbing Zhou
    Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
    Breast Cancer Res Treat 111:419-27. 2008
    ..This study suggests that breast cancer stem-like cells could be selectively inhibited by targeting signaling pathways important for breast cancer stem-like cells...
  63. ncbi Suberosols A-D, four new sesquiterpenes with beta-caryophyllene skeletons from a Taiwanese gorgonian coral Subergorgia suberosa
    Guey Horng Wang
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 65:887-91. 2002
    Four new beta-caryophyllene-derived sesquiterpenes alcohols, suberosols A (1), B (2), C (3), and D (4), along with two known beta-caryophyllene-derived sesqueterpene ketones, buddledins C (5) and D (6), were isolated from a Taiwanese ..
  64. pmc Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation
    Elena Butturini
    Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
    PLoS ONE 6:e20174. 2011
    ..We conclude that these two sesquiterpene lactones are able to induce redox-dependent post-translational modification of cysteine residues of STAT3 protein in order to regulate its function...
  65. pmc A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties
    Tobias G Köllner
    Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
    Plant Cell 20:482-94. 2008
    ..We argue that the (E)-beta-caryophyllene defense signal was lost during breeding of the North American lines and that its restoration might help to increase the resistance of these lines against agronomically important pests...
  66. ncbi A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia
    B Janssens
    Medecins Sans Frontieres, Phnom Penh, Cambodia
    Trop Med Int Health 12:251-9. 2007
    ..To compare the efficacy and tolerability of dihydroartemisinin-piperaquine (DHA-PQP) with that of a 3-day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia...
  67. ncbi Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
    Eardie A Curry
    Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA
    Invest New Drugs 22:299-305. 2004
    ..Feverfew has been used extensively without any formal pharmacokinetic analysis. A Phase I trial was conducted to evaluate the pharmacokinetics and toxicity of parthenolide given as a component of "feverfew."..
  68. ncbi Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
    C Cavin
    Quality and Safety Department, Nestle Research Center, P O Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Biochem Biophys Res Commun 327:742-9. 2005
    ..Altogether, the data presented strongly support chicory root as a promising source of functional food ingredient, combining prebiotic and anti-inflammatory properties...
  69. pmc OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice
    Atsushi Okada
    Biotechnology Research Center, The University of Tokyo, Tokyo 113 8657, Japan
    J Biol Chem 284:26510-8. 2009
    ....
  70. ncbi Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones
    Thomas J Schmidt
    Institut für Pharmazeutische Biologie der Heinrich Heine Universität, Dusseldorf, Germany
    Planta Med 68:750-1. 2002
    ..051 and 0.695 microM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation...
  71. pmc Metabolic engineering of sesquiterpene metabolism in yeast
    Shunji Takahashi
    Department of Plant and Soil Sciences, University of Kentucky, Lexington, Kentucky 40546 0312, USA
    Biotechnol Bioeng 97:170-81. 2007
    ....
  72. pmc Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea
    Mei Yan Wei
    School of Pharmacy, Guangdong Medical College, Dongguan, 523808, China
    Mar Drugs 8:941-9. 2010
    ..Their structures were elucidated by combined spectroscopic methods, and the structure of 1 was further confirmed by single-crystal X-ray data...
  73. ncbi Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways
    Duane C Hassane
    Department of Pathology and Laboratory Medicine, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA
    Blood 116:5983-90. 2010
    ..Taken together, our data show that rational drug combinations can be identified using chemical genomic screening strategies and that inhibition of cytoprotective functions can enhance the eradication of primary human AML cells...
  74. ncbi Activity of the corpora allata of adult female Aedes aegypti: effects of mating and feeding
    Yiping Li
    Department of Biochemistry and Molecular Biophysics, and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
    Insect Biochem Mol Biol 33:1307-15. 2003
    ..1986). The activity of the CA in Aedes aegypti females seems to be regulated by developmental changes and nutritional signals, and to be independent of mating stimulus...
  75. pmc High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli
    Hiroko Tsuruta
    Amyris Biotechnologies, Emeryville, California, United States of America
    PLoS ONE 4:e4489. 2009
    ....
  76. ncbi Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice
    Bokyung Sung
    Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Res 69:1477-84. 2009
    ....
  77. ncbi Molecular modes of action of artesunate in tumor cell lines
    Thomas Efferth
    Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
    Mol Pharmacol 64:382-94. 2003
    ..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
  78. pmc Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species
    Supachai Yodkeeree
    Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Cancer Res 69:6581-9. 2009
    ....
  79. pmc An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
    Monica L Guzman
    James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
    Blood 110:4427-35. 2007
    ..Therefore, based on the collective preclinical data, we propose that the novel compound DMAPT has the potential to target human LSCs in vivo...
  80. ncbi Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways
    Daniela Hampel
    Institut fur Lebensmittelchemie, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
    Phytochemistry 66:305-11. 2005
    ..exclusively via the 1-deoxy-D-xylulose/2-C-methyl-D-erythritol-4-phosphate (DOXP/MEP) pathway, whereas sesquiterpenes are generated by the classical mevalonic acid pathway as well as by the DOXP/MEP route...
  81. pmc Antileishmanial activity of the terpene nerolidol
    Denise C Arruda
    Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Professor Lineu Prestes, 1374, CEP 05508 900, Sao Paulo, SP, Brazil
    Antimicrob Agents Chemother 49:1679-87. 2005
    ..In addition, biosynthesis of dolichols with 11 and 12 isoprene units was identified in Leishmania, as described for other trypanosomatids and Apicomplexa...
  82. ncbi Discrimination of alarm pheromone (E)-beta-farnesene by aphid odorant-binding proteins
    Huili Qiao
    Department of Agricultural Chemistry and Biotechnologies, University of Pisa via S Michele, Italy
    Insect Biochem Mol Biol 39:414-9. 2009
    ..We suggest that OBP3 could mediate response of aphids to the alarm pheromone...
  83. pmc Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus
    Sean Agger
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Avenue, St Paul, MN 55108, USA
    Mol Microbiol 72:1181-95. 2009
    ..cinereus and other Coprinus species...
  84. ncbi Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
    Manal Mohamed Elhassan Taha
    UPM MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400 UPM Serdang, Selangor, Malaysia
    Chem Biol Interact 186:295-305. 2010
    ..Therefore, ZER has great potential in the treatment of liver cancers...
  85. ncbi Monoterpenoid biosynthesis in Saccharomyces cerevisiae
    Marilyne Oswald
    UMR Santé de la Vigne et Qualité du Vin, Universite Louis Pasteur Strasbourg, Institut National de la Recherche Agronomique, Colmar, France
    FEMS Yeast Res 7:413-21. 2007
    ..We also showed that geraniol synthase expression affects the general ergosterol pathway, but in a manner dependent on the genetic background of the strain...
  86. ncbi Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose
    Jocelyn Dudley
    Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
    J Nutr Biochem 20:443-52. 2009
    ....
  87. pmc Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    Amar bir Singh Sidhu
    Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
    J Infect Dis 194:528-35. 2006
    ..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
  88. pmc Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice
    Aicha Saadane
    Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Am J Respir Cell Mol Biol 36:728-36. 2007
    ..IkappaB kinase may be a good target, and parthenolide and/or feverfew might be promising treatments for the excessive inflammation in CF...
  89. ncbi Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
    Akira Murakami
    Department of Biotechnological Science, Faculty of Biology Oriented Science and Technology, Kinki University, Wakayama 649 6493, Japan
    Carcinogenesis 23:795-802. 2002
    ..Taken together, our results indicate that ZER is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies...
  90. pmc Flavonoid phytoalexin-dependent resistance to anthracnose leaf blight requires a functional yellow seed1 in Sorghum bicolor
    Farag Ibraheem
    Department of Crop and Soil Sciences and Plant Biology Graduate Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Genetics 184:915-26. 2010
    ..sublineolum. Overall results demonstrate that the accumulation of sorghum 3-deoxyanthocyanidin phytoalexins and resistance to C. sublineolum in sorghum require a functional y1 gene...
  91. ncbi A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation
    T H Koo
    Anti-Cancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
    Planta Med 67:103-7. 2001
    ..These findings support that CTN inhibits NO production by down-regulating iNOS expression, at least, in part through the inhibition of I kappa Bs' phosphorylation and degradation, which are essential for the activation of NF-kappa B...
  92. ncbi Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice
    Mihye Kim
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 124:264-71. 2009
    ....
  93. ncbi Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone
    Chandra Kirana
    CSIRO Health Sciences and Nutrition, PO Box 10041, Kintore Avenue, Adelaide DC, South Australia 5000
    Nutr Cancer 45:218-25. 2003
    ..Zerumbone is effective as an anticancer agent, possibly by its apoptosis-inducing and antiproliferative influences. This latter possibility is currently being investigated...
  94. pmc CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata
    C Helvig
    Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 101:4024-9. 2004
    ..Heterologously expressed CYP15A1 from D. punctata or its ortholog from economically important species may be useful in the design and screening of selective insect control agents...
  95. ncbi Metabolic engineering to produce sesquiterpenes in yeast
    Beth E Jackson
    Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA
    Org Lett 5:1629-32. 2003
    reaction: see text] Presented here is a metabolically engineered yeast strain that produces sesquiterpenes. Epi-cedrol synthase expressed in a native yeast strain converted endogenous farnesyl pyrophosphate to 90 microg/L epi-cedrol...
  96. ncbi Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
    Harikrishna Nakshatri
    Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
    Oncogene 23:7330-44. 2004
    ..These results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistance of cancer cells to TRAIL, particularly those with elevated XIAP levels...
  97. ncbi Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells
    Siyuan Zhang
    Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, Singapore 117597, Republic of Singapore
    Carcinogenesis 25:2191-9. 2004
    ..It is thus believed that suppressed NF-kappaB activation and sustained JNK activation contribute to the sensitization effect of PN to TNF-alpha-mediated cell death in human cancer cells...
  98. ncbi Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase
    Eric M Paradise
    Department of Chemical Engineering, University of California, Berkeley, California 94720, USA
    Biotechnol Bioeng 100:371-8. 2008
    ..The levels of these three metabolites were dependent not only upon the level of ERG9 repression, but also the timing of its repression relative to the induction of ADS and genes responsible for enhancing flux to FPP...
  99. ncbi The sesquiterpene hydrocarbons of maize (Zea mays) form five groups with distinct developmental and organ-specific distributions
    Tobias G Köllner
    Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, D 07745 Jena, Germany
    Phytochemistry 65:1895-902. 2004
    ..Approximately 25% of the stored pool was found to be released from young seedlings per hour. The individual sesquiterpenes varied extensively in their abundance among different organs and developmental stages...
  100. ncbi Systemic root signalling in a belowground, volatile-mediated tritrophic interaction
    Ivan Hiltpold
    FARCE Laboratory, University of Neuchatel, Rue Emile Argand 11, 2000 Neuchatel, Switzerland
    Plant Cell Environ 34:1267-75. 2011
    ..In belowground olfactometers, the nematodes were significantly more attracted towards local feeding sites than systemically induced roots. The possible advantages and disadvantages of systemic volatile signalling in roots are discussed...
  101. ncbi The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a defense against a bacterial pathogen
    Mengsu Huang
    Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
    New Phytol 193:997-1008. 2012
    ..E)-β-Caryophyllene thus appears to serve as a defense against pathogens that invade floral tissues and, like other floral volatiles, may play multiple roles in defense and pollinator attraction...

Research Grants62

  1. The Fulvene Approach to the Syntheses of Antitumor Agents
    Ihsan Erden; Fiscal Year: 2013
    ..The compounds of interest are members of the Illudin family of sesquiterpenes, the most prominent members of which, in terms of cytotoxicity are Illudin S and Illudin M...
  2. Tools to Fight Cancer: Exploiting Heck-type Olefinations to Forge Medium Rings
    Jennifer L Roizen; Fiscal Year: 2012
    ..to a class of molecules with broad yet selective anti-cancer and anti-alzheimers activities: the guaianolide sesquiterpenes. The guaianolide sesquiterpenes include dehydrocostuslactone, and thiapsigargin...
  3. NEW CATALYSTS FOR ASYMMETRIC DIELS-ALDER REACTIONS
    Peter Mackenzie; Fiscal Year: 1991
    ..The preparation of pharmacologically important steroids, alkaloids and sesquiterpenes are just a few of the many applications of this reaction...
  4. Enantioselective Synthesis of Halogenated Chamigrenes
    JEREMY MORGAN; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Several structurally interesting halogenated chamigrene sesquiterpenes have recently been isolated from the red algal genus Laurencia...
  5. BRIDGEHEAD INTERMEDIATES IN SYNTHESIS
    George Kraus; Fiscal Year: 1991
    ..3.0) ring system. An immediate application is the antibiotic pentalenolactone E; and 4) the study of the cycloadditions of bridgehead enals with electron-rich alkenes. An immediate application is the isocedrene class of sesquiterpenes.
  6. SYNTHETIC STUDIES OF CYTOTOXIC NATURAL PRODUCTS
    FREDERICK ZIEGLER; Fiscal Year: 1980
    ..rearrangements and stereocontrolled Michael additions of sulfur anions are being employed in the total synthesis of pseudo-guaianolide and secoeudesmane sesquiterpenes. Members of these classes have been shown to have anti-tumor activity.
  7. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  8. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  9. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  10. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  11. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  12. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  13. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  14. COORDINATED REGULATION OF ANTIOXIDANT ENZYMES
    Michael Kelner; Fiscal Year: 2005
    ..abstract_text> ..
  15. GPX1 ENZYME REGULATION BY OXIDATIVE XENOBIOTICS
    Michael Kelner; Fiscal Year: 2002
    ..These studies will provide critical information regarding cellular response to oxidative stress and aid in determining if a common regulatory mechanism exists for GSH-dependent enzymes. ..
  16. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  17. Inhibition of Alzheimer's Beta-Amyloid Fibril Formation
    Duy Hua; Fiscal Year: 2009
    ..However, soluble oligomeric Abeta showed high neuronal toxicity. Inhibition of the formation of these toxic soluble Abeta oligomers would provide therapeutics for AD. ..
  18. Halogenated Alkenes and Microsomal GSH-transferases
    Michael J Kelner; Fiscal Year: 2010
    ..4] To determine the relative contribution of MGST1 and MGST2 to cellular antioxidant capacity through studies utilizing human MGST1 and MGST2 null cells. ..
  19. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  20. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  21. Neural Substrates of Socioemotional Development
    Ludise Malkova; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  23. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  24. Generalized Varying-Coefficient Partially Linear Models
    Hua Liang; Fiscal Year: 2007
    ..The proposed research is expected to benefit semiparametric modeling as well as AIDS research. ..
  25. Seizures & Amydala-Based Socioemotional Dysfunction
    Ludise Malkova; Fiscal Year: 2007
    ..The team is ideally suited to approach the analysis of comorbidity of seizures and autistic-like symptoms evoked from amygdala and to permit a translationally meaningful analysis of the animal data. [unreadable] [unreadable] [unreadable]..
  26. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  27. Amnis ImageStream Flow Cytometer
    Craig Jordan; Fiscal Year: 2007
    ..Taken together, the unique capabilities of the ImageStream system will therefore serve to strongly benefit a wide range of research activities. [unreadable] [unreadable] [unreadable]..
  28. Evaluation of resveratrol and curcumin as therapeutics against high-risk leukemia
    SUSAN ZUNINO; Fiscal Year: 2008
    ..These studies will provide information about whether the plant antioxidants resveratrol and curcumin may be novel and efficient alternatives for the treatment of high-risk leukemia. [unreadable] [unreadable] [unreadable]..
  29. Thioredoxin in Neutrophil-Airway Epithelial Interactions
    Karen Oslund; Fiscal Year: 2008
    ..She hopes to use a career research award to gain additional knowledge and training in molecular biology while transitioning to an independent researcher who will be competitive for R01 funding. [unreadable] [unreadable] [unreadable]..
  30. Role of USP Ligand Binding Pocket During Development
    Grace Jones; Fiscal Year: 2008
    ..The outcome will have broad implications for insect endocrinology, enabling specific tests on the Aedes USP, the results of which will yield new insights on hormonal signaling in the technically more difficult mosquito. ..
  31. Cellular and Molecular Studies of Leukemic Stem Cellss
    Craig Jordan; Fiscal Year: 2006
    ..Collectively, these efforts will advance our understanding of basic mechanisms that underlie leukemic transformation and will improve strategies for the preferential ablation of LSCs. ..
  32. Selective in vivo Ablation of Leukemia Stem Cells
    Craig Jordan; Fiscal Year: 2009
    ..Collectively, the proposed studies will provide a detailed evaluation of how therapeutic agents impact the growth and survival of LSC in vivo. ..
  33. A Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids
    REUBEN JOHN PETERS; Fiscal Year: 2010
    ..Bacterial production will provide an effective source for production of the larger amounts of these natural products necessary for detailed investigation of their promising biological activity. ..
  34. Molecular Imaging of Angiogenesis by MRI
    Gregory Lanza; Fiscal Year: 2007
    ..Apply mathematical models of tissue compartmentalization to determine the contributions of target binding and vascular permeability to MRI signal enhancement. ..
  35. NEW RHODIUM-CATALYZED ALLYLIC ALKYLATION REACTIONS
    P Evans; Fiscal Year: 2006
    ..The development of a temporary silicon-tethered (TST) rhodium-catalyzed [4+2+2] carbocyclization approach to the diterpene, epoxydictymene. ..
  36. Congenital and neonatal malaria in Mali
    Abdoulaye Djimde; Fiscal Year: 2006
    ..research grant ..
  37. Anti-Trypanosomal Agents from a Neotropical Cloudforest
    WILLIAM SETZER; Fiscal Year: 2004
    ..The long-term benefit of this research project is the development of new medicines to treat patients with Chagas disease. ..
  38. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  39. Nicotinic Receptors in Septally Innervated Hippocampus
    EDSON ALBUQUERQUE; Fiscal Year: 2004
    ....
  40. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  41. Pilot Study of Huperzine A in Alzheimer's Disease
    Paul Aisen; Fiscal Year: 2003
    ....
  42. Neural Substrates /Socioemotional Disturbances /Develop.
    Ludise Malkova; Fiscal Year: 2003
    ..This information will provide a rationale basis for the design of therapeutic interventions directed at correcting the underlying biological dysfunctions that give rise to autism and related socioemotional disorders. ..
  43. MOLECULAR REGULATION OF THE HUMAN BRCA 1 GENE
    DONATO ROMAGNOLO; Fiscal Year: 2003
    ..Specific aim #3 will examine the function of BRCA-1 in cell cycle regulation at different levels of genotoxic damage induced by PAHs. ..
  44. PREPUPAL ACTIVATION OF JH ESTERASE GENE
    Grace Jones; Fiscal Year: 2003
    ..abstract_text> ..
  45. Pathogenesis of falciparum malaria in infancy
    Patrick Duffy; Fiscal Year: 2004
    ..Identifying new therapies for children is an urgent public health goal, but is not a funding priority for the United States Department of Defense. ..
  46. STRUCTURAL AND FUNCTIONAL LIGAND-BINDING FEATURES OF USP
    Grace Jones; Fiscal Year: 2002
    ....
  47. Biology of CHK2 Kinase In Lung Cancer
    Weixin Wang; Fiscal Year: 2005
    ....
  48. Analysis of AIDS Data by Using Semiparametrical Models
    Hua Liang; Fiscal Year: 2006
    ..The proposed research is expected to benefit studies of the immune system in HIV-infected patients (one of the main focuses of future AIDS research). ..
  49. Mentored Research in Ovarian Cancer
    Michael Seiden; Fiscal Year: 2006
    ..The P.l.'s dual role as a clinical research director and laboratory P.I. provides fertile opportunity for translation between the clinic and the laboratory. [unreadable] [unreadable] [unreadable] [unreadable]..
  50. Regulation of BCL-2 and Tumorigenicity
    Marc Mendonca; Fiscal Year: 2006
    ..abstract_text> ..
  51. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  52. MATERNAL MALARIA--PARASITE ADHESION AND ANTIBODIES
    Patrick Duffy; Fiscal Year: 2001
    ..Further, the delineation of binding domains and B cell epitopes will provide the basis to design an anti-adhesion vaccine to protect primigravid and other women susceptible to placental infection with the CSA-binding parasites. ..
  53. STEREOSELECTIVE SYNTHESIS OF CYCLIC ETHERS
    P Evans; Fiscal Year: 2006
    ..Finally, we will examine a series bismuth-catalyzed bis-reductive etherification reactions for the construction of linear fused polycyclic ethers. ..
  54. TOTAL SYNTHESIS OF SCABRONINE A
    GREGORY DUDLEY; Fiscal Year: 2002
    ..The proposed strategy utilizes a novel coupling annulation to assemble the seven-membered ring. ..
  55. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  56. PROTEIN SYNTHESIS INITIATION IN ANIMAL CELLS
    Bansidhar Datta; Fiscal Year: 2002
    ..This research is expected to provide valuable information regarding the mechanism of protein synthesis initiation in normal, cancerous, and virus- infected animal cells. ..