- Production of the antimalarial drug precursor artemisinic acid in engineered yeast
Dae Kyun Ro
California Institute of Quantitative Biomedical Research, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
Nature 440:940-3. 2006
..annua, yield optimization and industrial scale-up will be required to raise artemisinic acid production to a level high enough to reduce artemisinin combination therapies to significantly below their current prices...
- Plant sesquiterpenes induce hyphal branching in arbuscular mycorrhizal fungi
Division of Applied Biological Chemistry, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
Nature 435:824-7. 2005
..The natural strigolactones 5-deoxy-strigol, sorgolactone and strigol, and a synthetic analogue, GR24, induced extensive hyphal branching in germinating spores of the AM fungus Gigaspora margarita at very low concentrations...
- Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum
M B Reed
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia
Nature 403:906-9. 2000
..This has important implications for the development and efficacy of future antimalarial agents...
- Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
A J García-Piñeres
Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
J Biol Chem 276:39713-20. 2001
..Although a slight inhibition of IkappaB degradation was detected for all SLs, the amount of remaining IkappaB was too low to explain the observed NF-kappaB inhibition...
- Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand
Lancet 366:717-25. 2005
..In the treatment of severe malaria, intravenous artesunate is more rapidly acting than intravenous quinine in terms of parasite clearance, is safer, and is simpler to administer, but whether it can reduce mortality is uncertain...
- Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
Amar bir Singh Sidhu
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Science 298:210-3. 2002
..pfcrt mutations increased susceptibility to artemisinin and quinine and minimally affected amodiaquine activity; hence, these antimalarials warrant further investigation as agents to control chloroquine-resistant falciparum malaria...
- Hirsutane sesquiterpenoids from the marine-derived fungus Chondrostereum sp
Hou Jin Li
School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, P R China
Chem Biodivers 8:317-24. 2011
..The structures were elucidated mainly on the basis of the NMR, MS, and X-ray single-crystal diffraction data. Hirsutanol A (2) exhibited potent cytotoxic activities against various cancer cell lines...
- Recruitment of entomopathogenic nematodes by insect-damaged maize roots
University of Neuchatel, Institute of Zoology, Laboratory of Animal Ecology and Entomology, CP 2, CH 2007 Neuchatel, Switzerland
Nature 434:732-7. 2005
..Development of new varieties that release the attractant in adequate amounts should help enhance the efficacy of nematodes as biological control agents against root pests like D. v. virgifera...
- A fungal-responsive MAPK cascade regulates phytoalexin biosynthesis in Arabidopsis
State Key Laboratory of Plant Physiology and Biochemistry, China Agricultural University, Beijing 100094, China
Proc Natl Acad Sci U S A 105:5638-43. 2008
..These results indicate that the MPK3/MPK6 cascade regulates camalexin synthesis through transcriptional regulation of the biosynthetic genes after pathogen infection...
- Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway
Department of Internal Medicine, Division of Hematology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku Tokyo, 160 8582 Japan
Cancer Sci 98:118-26. 2007
..Taken together, ZER is an inducer of apoptosis in leukemic cells that specifically triggers the Fas/CD95- and mitochondria-mediated apoptotic signaling pathway...
- Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering
Mohammad A Asadollahi
Center for Microbial Biotechnology CMB, Department of Systems Biology, Building 223, Technical University of Denmark DTU, DK 2800 Kgs Lyngby, Denmark
Metab Eng 11:328-34. 2009
A genome-scale metabolic model was used to identify new target genes for enhanced biosynthesis of sesquiterpenes in the yeast Saccharomyces cerevisiae. The effect of gene deletions on the flux distributions in the metabolic model of S...
- Terpenoid metabolism in wild-type and transgenic Arabidopsis plants
Plant Research International, 6700 AA, Wageningen, The Netherlands
Plant Cell 15:2866-84. 2003
..Most of the volatiles detected were monoterpenes and sesquiterpenes, which in contrast to other volatiles showed a diurnal emission pattern...
- Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
Ric N Price
Department of Cellular and Molecular Medicine Infectious Diseases, St George s Hospital Medical School, London, UK
Lancet 364:438-47. 2004
..A combination of artesunate with mefloquine now cures more than 95% of acute infections. For both treatment regimens, the underlying mechanisms of resistance are not known...
- Antiproliferative effect of beta-elemene in chemoresistant ovarian carcinoma cells is mediated through arrest of the cell cycle at the G2-M phase
The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
Cell Mol Life Sci 62:894-904. 2005
- (Sub)microscopic Plasmodium falciparum gametocytaemia in Kenyan children after treatment with sulphadoxine-pyrimethamine monotherapy or in combination with artesunate
Radboud University Nijmegen Medical Centre, Medical Microbiology 268, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
Int J Parasitol 36:403-8. 2006
..Our data suggest that the potential of malaria transmission remains high even after treatment with artemisinin combination therapy, although prevalence and density of gametocytes is lower after SP+AS...
- What made sesquiterpene lactones reach cancer clinical trials?
Biology Department, American University of Beirut, Beirut, Lebanon
Drug Discov Today 15:668-78. 2010
..These drugs are selective toward tumor and cancer stem cells by targeting specific signaling pathways, which make them lead compounds in cancer clinical trials...
- Two novel tyrosinase inhibitory sesquiterpenes induced by CuCl2 from a marine-derived fungus Pestalotiopsis sp. Z233
Ocean College, Zhejiang University, Hangzhou 310058, China
Mar Drugs 11:2713-21. 2013
Two new sesquiterpenes, 1Î²,5Î±,6Î±,14-tetraacetoxy-9Î±-benzoyloxy-7Î² H-eudesman-2Î²,11-diol (1) and 4Î±,5Î±-diacetoxy-9Î±-benzoyloxy-7Î²H-eudesman-1Î²,2Î²,11, 14-tetraol (2), were produced as stress metabolites ..
- Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
Susan J Zunino
United States Department of Agriculture, Agricultural Research Service, Western Human Nutrition Research Center, University of California, Davis, CA 95616, USA
Cancer Lett 254:119-27. 2007
..Parthenolide-induced elevation of hypochlorite anion was observed only in the two t(4;11) lines. These data suggest parthenolide may have potential as a potent and novel therapeutic agent against pre-B ALLs...
- Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells
Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, Singapore 117597
Cancer Lett 208:143-53. 2004
..These data clearly demonstrate that the intracellular thiols and calcium equilibrium play a critical role in parthenolide-induced apoptotic cell death...
- Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells
Central Research Laboratory, Jilin University Bethune Second Hospital, Changchun 130041, PR China
Int J Biol Sci 8:533-47. 2012
..Therefore, isoalantolactone may be a safe chemotherapeutic candidate for the treatment of human pancreatic carcinoma...
- Artemisinin: mechanisms of action, resistance and toxicity
Steven R Meshnick
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill 27599 7435, USA
Int J Parasitol 32:1655-60. 2002
..At high doses, artemisinin can be neurotoxic but toxicity has not been found in clinical studies. The mechanism of neurotoxicity may be similar to the mechanism of action...
- Antitumor effect of beta-elemene in non-small-cell lung cancer cells is mediated via induction of cell cycle arrest and apoptotic cell death
The Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University Health Sciences Center, Morgantown, West Virginia 26506, USA
Cell Mol Life Sci 62:881-93. 2005
..These data indicate that the effect of beta-elemene on lung cancer cell death may be through a mitochondrial release of the cytochrome c-mediated apoptotic pathway...
- Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms
Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Republic of Singapore
Curr Med Chem Anticancer Agents 5:239-49. 2005
..Taken together, many SLs are emerging as promising anti-cancer agents with potential applications in both cancer chemotherapy and chemoprevention...
- Oxidative stress-mediated apoptosis. The anticancer effect of the sesquiterpene lactone parthenolide
Division of Gastroenterology and Hepatology, Departments of Internal Medicine and Anatomy Research Institute for Clinical Medicine, Chonbuk National University Medical School and Hospital, Chonju, Chonbuk 561 712, Republic of Korea
J Biol Chem 277:38954-64. 2002
..Finally, parthenolide and its derivatives may be useful chemotherapeutic agents to treat these invasive cancers...
- Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion
Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Box 143, Houston, TX 77030, USA
Oncogene 24:6957-69. 2005
- Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells
Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
Cancer Res 68:8938-44. 2008
..Overall, our results show that zerumbone is a novel inhibitor of CXCR4 expression and thus has a potential in the suppression of cancer metastasis...
- Phytoalexin transgenics in crop protection--fairy tale with a happy end?
Dominik K Großkinsky
Institute of Plant Sciences, Department of Plant Physiology, University of Graz, Schubertstraße 51, 8010 Graz, Austria
Plant Sci 195:54-70. 2012
..Based on this, the advantages as well as potential bottlenecks for molecular approaches of modulating inducible phytoalexins to improve crop protection are discussed...
- Evidence that IL-6-type cytokine signaling in cardiomyocytes is inhibited by oxidative stress: parthenolide targets JAK1 activation by generating ROS
The Division of Molecular Cardiology, The Cardiovascular Research Institute, The Texas A and M University System Health Science Center, Scott and White, Central Texas Veterans Health Care System, Temple, Texas 76504, USA
J Cell Physiol 212:424-31. 2007
..The finding that signaling by the IL-6-type cytokine may be redox-sensitive defines a novel mechanism of regulation that has implications for exploiting their therapeutic potential...
- Intrathecal lemnalol, a natural marine compound obtained from Formosan soft coral, attenuates nociceptive responses and the activity of spinal glial cells in neuropathic rats
Ying Chao Lin
Division of Neuro Medical Scientific Center, Buddhist Tzu Chi General Hospital, Taichung Branch, Taiwan
Behav Pharmacol 22:739-50. 2011
..Collectively, our results indicate that lemnalol is a potential therapeutic agent for neuropathic pain, and that further exploration of the effects of lemnalol on glial proinflammatory responses is warranted...
- Effects of huperzine A on memory deficits and neurotrophic factors production after transient cerebral ischemia and reperfusion in mice
Zhi Fei Wang
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China
Pharmacol Biochem Behav 83:603-11. 2006
..It also indicates that the MAPK/ERK pathway might be involved in the in vivo neurotrophic effects of huperzine A against transient cerebral ischemia and reperfusion...
- Lochmolins A-G, new sesquiterpenoids from the soft coral Sinularia lochmodes
Yen Ju Tseng
Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
Mar Drugs 10:1572-81. 2012
..The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1-4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells...
- The rice (E)-beta-caryophyllene synthase (OsTPS3) accounts for the major inducible volatile sesquiterpenes
Ai Xia Cheng
National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China
Phytochemistry 68:1632-41. 2007
..In vitro, the recombinant protein of OsTPS3 catalyzed formation of (E)-beta-caryophyllene and several other sesquiterpenes, including beta-elemene and alpha-humulene, all being components of inducible volatiles of rice plants...
- In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma
Mary Babb Randolph Cancer Center, Department of Microbiology, Immunology and Cell Biology, West Virginia University, Morgantown, WV 26506, USA
Int J Oncol 31:241-52. 2007
..Finally, the beta-elemene-induced alteration of cell membrane permeability, which has potential to result in enhanced cellular uptake of taxanes, may also contribute to the synergistic interactions of the combination treatments...
- Induction of apoptosis by costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction
Dental Hospital, Jilin University, Changchun 130041, China
Molecules 18:1418-33. 2013
..These findings provide the rationale for further in vivo and clinical investigation of costunolide against human bladder cancer...
- Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation
Yi Qun Yao
Department of Neurosurgery, 1st Affiliated Hospital of Dalian Medical University, Dalian, China
Cancer Lett 264:127-34. 2008
..Taken together, our findings indicate that activation of p38 MAPK is critical for the anti-proliferation effect of beta-elemene and that p38 MAPK might be a putative pharmacological target for glioblastoma therapy...
- Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Scienze Biochimiche, Universita di Palermo, Policlinico, Palermo, Italy
J Cell Physiol 226:1632-41. 2011
..Our results suggest that co-treatment with parthenolide and TRAIL could represent a new important therapeutic strategy for hepatic tumors...
- A phase II trial of huperzine A in mild to moderate Alzheimer disease
M S Rafii
Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
Neurology 76:1389-94. 2011
..Huperzine A is a natural cholinesterase inhibitor derived from the Chinese herb Huperzia serrata that may compare favorably in symptomatic efficacy to cholinesterase inhibitors currently in use for Alzheimer disease (AD)...
- Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
German Cancer Research Center, M070, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Curr Drug Targets 7:407-21. 2006
..g. the translationally controlled tumor protein (TCTP). Emphasis is given to pharmacogenomic approaches to analyze the pleiotropic nature of mechanisms of artemisinins in cancer cells...
- In vitro anti-plasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent, structure-activity relationship studies and gene expression profiling
John V W Becker
Biosciences, CSIR, PO Box 395, Pretoria, 0001, South Africa
Malar J 10:295. 2011
..One of the plants selected for investigation was Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile...
- Ylangene-type and nardosinane-type sesquiterpenoids from the soft corals Lemnalia flava and Paralemnalia thyrsoides
Shi Yie Cheng
Department of Marine Biotechnology and Resources, National Sun Yat Sen University
Chem Pharm Bull (Tokyo) 58:381-5. 2010
..The structures of metabolites 1 and 4-6 were elucidated through extensive spectroscopic analysis and chemical methods. Moreover, the anti-inflammatory activity of metabolites 1-7 and 11 was evaluated in vitro...
- The biosynthesis of isoprenoids and the mechanisms regulating it in plants
Biotechnology Research Center, The University of Tokyo, Japan
Biosci Biotechnol Biochem 75:1219-25. 2011
- Tehranolide molecule modulates the immune response, reduce regulatory T cell and inhibits tumor growth in vivo
Department of Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Mol Immunol 47:1579-84. 2010
..05) decreased the number of these lymphocytes. These findings show that the use of Tehranolide molecule represents a novel strategy with major suggestions for cancer therapy approaches...
- Enhancement of natural disease resistance in potatoes by chemicals
Adriana B Andreu
Instituto de Investigaciones Biologicas, Universidad Nacional de Mar del Plata, Funes 3250, 7600 Mar del Plata, Argentina
Pest Manag Sci 62:162-70. 2006
..This treatment may offer the possibility of controlling both foliage and tuber blight and could have a major impact in reducing over-winter survival of P. infestans in tubers...
- The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes
John P Fallon
Medical Mycology Unit, Department of Biology, National Institute for Cellular Biotechnology, National University of Ireland Maynooth, Co Kildare, Ireland
Microbiology 157:1481-8. 2011
..During growth of the fungus in the larvae, this toxin, along with others, may facilitate growth by suppressing the cellular immune response...
- The effects of abiotic factors on induced volatile emissions in corn plants
Sandrine P Gouinguené
Institute of Zoology, Laboratory of Animal Ecology and Entomology, University of Neuchatel, Case Postale 2, CH 2007 Neuchatel, Switzerland
Plant Physiol 129:1296-307. 2002
..Hence, climatic conditions and nutrient availability can be important factors in determining the intensity and variability in the release of induced plant volatiles...
- Artemisinin-based combinations
Elizabeth A Ashley
Shoklo Malaria Research Unit, Mae Sot, Tak, Thailand
Curr Opin Infect Dis 18:531-6. 2005
..Artemisinin-based combination treatments have been the mainstay of treatment for falciparum malaria in Southeast Asia for more than 10 years and are now increasingly recommended as first-line treatment throughout the rest of the world...
- Cytotoxic and anti-infective sesquiterpenes present in Plagiochila disticha (Plagiochilaceae) and Ambrosia peruviana (Asteraceae)
José C Aponte
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA
Planta Med 76:705-7. 2010
- Hirsutanol A induces apoptosis and autophagy via reactive oxygen species accumulation in breast cancer MCF-7 cells
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat Sen University, Guangzhou, 510060, China
J Pharmacol Sci 119:214-20. 2012
..These data suggested that hirsutanol A could induce apoptosis and autophagy via accumulation of ROS and co-treatment with an autophagy inhibitor could sensitize MCF-7 cells to hirsutanol A...
- Characterization of CYP76M5-8 indicates metabolic plasticity within a plant biosynthetic gene cluster
Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
J Biol Chem 287:6159-68. 2012
..The implications for the underlying metabolic evolution of plants are then discussed...
- Oxidative and endoplasmic reticulum stress signaling are involved in dehydrocostuslactone-mediated apoptosis in human non-small cell lung cancer cells
Jen Yu Hung
Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Lung Cancer 68:355-65. 2010
..This study demonstrates that DHE may be a novel anticancer agent for the treatment of non-small cell lung cancer...
- Metabolic engineering of Escherichia coli for α-farnesene production
Division of Applied Life Science BK21 program, EB NCRC and PMBBRC, Gyeongsang National University, Jinju 660 701, Republic of Korea
Metab Eng 13:648-55. 2011
b>Sesquiterpenes are important materials in pharmaceuticals and industry. Metabolic engineering has been successfully used to produce these valuable compounds in microbial hosts...
- Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-kappaB inhibitor, DMAPT (LC-1)
Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA
Bioorg Med Chem Lett 19:4346-9. 2009
..5-3.0microM). Compounds 16, 24 and 30 were the most potent compounds in the series, causing greater than 90% cell death at 10microM concentration against primary AML cells in culture, with LD(50) values of 1.7, 1.8 and 1.6microM...
- Parthenolide promotes the ubiquitination of MDM2 and activates p53 cellular functions
Y N Vashisht Gopal
Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Unit 079, 1515 Holcombe Boulevard, Houston, TX 77030 4009, USA
Mol Cancer Ther 8:552-62. 2009
..Our study illustrates an alternative approach for controlling MDM2 and p53 activities and identifies an additional critically important cancer pathway affected by PN...
- Stabilization and translocation of p53 to mitochondria is linked to Bax translocation to mitochondria in simvastatin-induced apoptosis
Sang Kyu Lee
Department of Biochemistry, College of Natural Sciences, Chungnam National University, Daejeon 305 764, Republic of Korea
Biochem Biophys Res Commun 391:1592-7. 2010
..Taken together, these all indicate that stabilization and translocation of p53 to mitochondria is involved in Bax translocation to mitochondria in simvastatin-induced apoptosis...
- The NF (Nuclear factor)-κB inhibitor parthenolide interacts with histone deacetylase inhibitors to induce MKK7/JNK1-dependent apoptosis in human acute myeloid leukaemia cells
Division of Hematology Oncology, Department of Medicine, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA
Br J Haematol 151:70-83. 2010
..They also raise the possibility that this strategy may target leukaemic progenitor cells...
- Evaluation of mosquitocidal activity of essential oil and sesquiterpenes from leaves of Chloroxylon swietenia DC
S Ravi Kiran
Department of Botany, Osmania University, Hyderabad, 500007, India
Parasitol Res 101:413-8. 2007
..Encouraged by this, the essential oil and the sesquiterpenes isolated from the leaves of Chloroxylon swietenia DC...
- The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase
B H Kwok
Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520-8103, USA
Chem Biol 8:759-66. 2001
..In addition, these results may be useful in the development of additional anti-inflammatory agents...
- The natural products parthenolide and andrographolide exhibit anti-cancer stem cell activity in multiple myeloma
Ellen J Gunn
Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
Leuk Lymphoma 52:1085-97. 2011
..This is the first report of a natural product with anti-CSC activity in myeloma, suggesting that it has the potential to improve the survival of patients with MM by eliminating the relapse-causing MM-CSCs...
- Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes
Laboratory of Food and Biodynamics, Nagoya University Graduate School of Bioagricultural Sciences, Nagoya 464 8601, Japan
FEBS Lett 572:245-50. 2004
..The present study also implied the antioxidant role of this detoxification system activation by ZER in the neutralization of lipid peroxidation in hepatocytes, providing a new insight for cancer prevention...
- Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice
M R Sulaiman
Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Fitoterapia 81:855-8. 2010
..It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test...
- Sesquiterpene synthase from the botrydial biosynthetic gene cluster of the phytopathogen Botrytis cinerea
Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Cadiz, Puerto Real, Spain
ACS Chem Biol 3:791-801. 2008
..Recombinant BcBOT2 protein converted farnesyl diphosphate to the parent sesquiterpene of the botrydial biosynthetic pathway, the tricyclic alcohol presilphiperfolan-8beta-ol...
- NF-kappaB pathway inhibitors preferentially inhibit breast cancer stem-like cells
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA
Breast Cancer Res Treat 111:419-27. 2008
..This study suggests that breast cancer stem-like cells could be selectively inhibited by targeting signaling pathways important for breast cancer stem-like cells...
- Suberosols A-D, four new sesquiterpenes with beta-caryophyllene skeletons from a Taiwanese gorgonian coral Subergorgia suberosa
Guey Horng Wang
Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
J Nat Prod 65:887-91. 2002
Four new beta-caryophyllene-derived sesquiterpenes alcohols, suberosols A (1), B (2), C (3), and D (4), along with two known beta-caryophyllene-derived sesqueterpene ketones, buddledins C (5) and D (6), were isolated from a Taiwanese ..
- Two naturally occurring terpenes, dehydrocostuslactone and costunolide, decrease intracellular GSH content and inhibit STAT3 activation
Department of Life and Reproduction Sciences, University of Verona, Verona, Italy
PLoS ONE 6:e20174. 2011
..We conclude that these two sesquiterpene lactones are able to induce redox-dependent post-translational modification of cysteine residues of STAT3 protein in order to regulate its function...
- A maize (E)-beta-caryophyllene synthase implicated in indirect defense responses against herbivores is not expressed in most American maize varieties
Tobias G Köllner
Max Planck Institute for Chemical Ecology, D 07745 Jena, Germany
Plant Cell 20:482-94. 2008
..We argue that the (E)-beta-caryophyllene defense signal was lost during breeding of the North American lines and that its restoration might help to increase the resistance of these lines against agronomically important pests...
- A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia
Medecins Sans Frontieres, Phnom Penh, Cambodia
Trop Med Int Health 12:251-9. 2007
..To compare the efficacy and tolerability of dihydroartemisinin-piperaquine (DHA-PQP) with that of a 3-day regimen of mefloquine and artesunate (MAS3) for the treatment of uncomplicated falciparum malaria in Cambodia...
- Phase I dose escalation trial of feverfew with standardized doses of parthenolide in patients with cancer
Eardie A Curry
Department of Pharmacy Practice, Purdue University, Indianapolis, IN, USA
Invest New Drugs 22:299-305. 2004
..Feverfew has been used extensively without any formal pharmacokinetic analysis. A Phase I trial was conducted to evaluate the pharmacokinetics and toxicity of parthenolide given as a component of "feverfew."..
- Inhibition of the expression and activity of cyclooxygenase-2 by chicory extract
Quality and Safety Department, Nestle Research Center, P O Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
Biochem Biophys Res Commun 327:742-9. 2005
..Altogether, the data presented strongly support chicory root as a promising source of functional food ingredient, combining prebiotic and anti-inflammatory properties...
- OsTGAP1, a bZIP transcription factor, coordinately regulates the inductive production of diterpenoid phytoalexins in rice
Biotechnology Research Center, The University of Tokyo, Tokyo 113 8657, Japan
J Biol Chem 284:26510-8. 2009
- Anti-trypanosomal activity of helenalin and some structurally related sesquiterpene lactones
Thomas J Schmidt
Institut für Pharmazeutische Biologie der Heinrich Heine Universität, Dusseldorf, Germany
Planta Med 68:750-1. 2002
..051 and 0.695 microM against T. brucei rhodesiense and T. cruzi, respectively. The low IC50 value for T. b. rhodesiense indicates that helenalin type compounds may be interesting candidates for further evaluation...
- Metabolic engineering of sesquiterpene metabolism in yeast
Department of Plant and Soil Sciences, University of Kentucky, Lexington, Kentucky 40546 0312, USA
Biotechnol Bioeng 97:170-81. 2007
- Five sesquiterpenoids from a marine-derived fungus Aspergillus sp. isolated from a gorgonian Dichotella gemmacea
Mei Yan Wei
School of Pharmacy, Guangdong Medical College, Dongguan, 523808, China
Mar Drugs 8:941-9. 2010
..Their structures were elucidated by combined spectroscopic methods, and the structure of 1 was further confirmed by single-crystal X-ray data...
- Chemical genomic screening reveals synergism between parthenolide and inhibitors of the PI-3 kinase and mTOR pathways
Duane C Hassane
Department of Pathology and Laboratory Medicine, Institute for Computational Biomedicine, Weill Cornell Medical College, New York, NY 10021, USA
Blood 116:5983-90. 2010
..Taken together, our data show that rational drug combinations can be identified using chemical genomic screening strategies and that inhibition of cytoprotective functions can enhance the eradication of primary human AML cells...
- Activity of the corpora allata of adult female Aedes aegypti: effects of mating and feeding
Department of Biochemistry and Molecular Biophysics, and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
Insect Biochem Mol Biol 33:1307-15. 2003
..1986). The activity of the CA in Aedes aegypti females seems to be regulated by developmental changes and nutritional signals, and to be independent of mating stimulus...
- High-level production of amorpha-4,11-diene, a precursor of the antimalarial agent artemisinin, in Escherichia coli
Amyris Biotechnologies, Emeryville, California, United States of America
PLoS ONE 4:e4489. 2009
- Zerumbone abolishes RANKL-induced NF-kappaB activation, inhibits osteoclastogenesis, and suppresses human breast cancer-induced bone loss in athymic nude mice
Department of Experimental Therapeutics, Cytokine Research Laboratory, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA
Cancer Res 69:1477-84. 2009
- Molecular modes of action of artesunate in tumor cell lines
Center for Molecular Biology of the University of Heidelberg ZMBH, Heidelberg, Germany
Mol Pharmacol 64:382-94. 2003
..ART acts via p53-dependent and- independent pathways in isogenic p53+/+ p21WAF1/CIP1+/+, p53-/- p21WAF1/CIP1+/+, and p53+/+ p21WAF1/CIP1-/- colon carcinoma cells...
- Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species
Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
Cancer Res 69:6581-9. 2009
- An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
Monica L Guzman
James P Wilmot Cancer Center, University of Rochester, NY 14642, USA
Blood 110:4427-35. 2007
..Therefore, based on the collective preclinical data, we propose that the novel compound DMAPT has the potential to target human LSCs in vivo...
- Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways
Institut fur Lebensmittelchemie, Johann Wolfgang Goethe Universitat, Marie Curie Strasse 9, D 60439 Frankfurt Main, Germany
Phytochemistry 66:305-11. 2005
..exclusively via the 1-deoxy-D-xylulose/2-C-methyl-D-erythritol-4-phosphate (DOXP/MEP) pathway, whereas sesquiterpenes are generated by the classical mevalonic acid pathway as well as by the DOXP/MEP route...
- Antileishmanial activity of the terpene nerolidol
Denise C Arruda
Departamento de Parasitologia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Av Professor Lineu Prestes, 1374, CEP 05508 900, Sao Paulo, SP, Brazil
Antimicrob Agents Chemother 49:1679-87. 2005
..In addition, biosynthesis of dolichols with 11 and 12 isoprene units was identified in Leishmania, as described for other trypanosomatids and Apicomplexa...
- Discrimination of alarm pheromone (E)-beta-farnesene by aphid odorant-binding proteins
Department of Agricultural Chemistry and Biotechnologies, University of Pisa via S Michele, Italy
Insect Biochem Mol Biol 39:414-9. 2009
..We suggest that OBP3 could mediate response of aphids to the alarm pheromone...
- Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus
Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, 1479 Gortner Avenue, St Paul, MN 55108, USA
Mol Microbiol 72:1181-95. 2009
..cinereus and other Coprinus species...
- Potential chemoprevention of diethylnitrosamine-initiated and 2-acetylaminofluorene-promoted hepatocarcinogenesis by zerumbone from the rhizomes of the subtropical ginger (Zingiber zerumbet)
Manal Mohamed Elhassan Taha
UPM MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400 UPM Serdang, Selangor, Malaysia
Chem Biol Interact 186:295-305. 2010
..Therefore, ZER has great potential in the treatment of liver cancers...
- Monoterpenoid biosynthesis in Saccharomyces cerevisiae
UMR Santé de la Vigne et Qualité du Vin, Universite Louis Pasteur Strasbourg, Institut National de la Recherche Agronomique, Colmar, France
FEMS Yeast Res 7:413-21. 2007
..We also showed that geraniol synthase expression affects the general ergosterol pathway, but in a manner dependent on the genetic background of the strain...
- Resveratrol, a unique phytoalexin present in red wine, delivers either survival signal or death signal to the ischemic myocardium depending on dose
Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030 1110, USA
J Nutr Biochem 20:443-52. 2009
- Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
Amar bir Singh Sidhu
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, Bronx, NY 10461, USA
J Infect Dis 194:528-35. 2006
..These results highlight the importance of pfmdr1 copy number in determining P. falciparum susceptibility to multiple agents currently being used to combat malaria caused by multidrug-resistant parasites...
- Parthenolide inhibits IkappaB kinase, NF-kappaB activation, and inflammatory response in cystic fibrosis cells and mice
Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Am J Respir Cell Mol Biol 36:728-36. 2007
..IkappaB kinase may be a good target, and parthenolide and/or feverfew might be promising treatments for the excessive inflammation in CF...
- Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the alpha,beta-unsaturated carbonyl group is a prerequisite
Department of Biotechnological Science, Faculty of Biology Oriented Science and Technology, Kinki University, Wakayama 649 6493, Japan
Carcinogenesis 23:795-802. 2002
..Taken together, our results indicate that ZER is a food phytochemical that has distinct potentials for use in anti-inflammation, chemoprevention, and chemotherapy strategies...
- Flavonoid phytoalexin-dependent resistance to anthracnose leaf blight requires a functional yellow seed1 in Sorghum bicolor
Department of Crop and Soil Sciences and Plant Biology Graduate Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Genetics 184:915-26. 2010
..sublineolum. Overall results demonstrate that the accumulation of sorghum 3-deoxyanthocyanidin phytoalexins and resistance to C. sublineolum in sorghum require a functional y1 gene...
- A sesquiterpene lactone, costunolide, from Magnolia grandiflora inhibits NF-kappa B by targeting I kappa B phosphorylation
T H Koo
Anti-Cancer Agent Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Taejon, Korea
Planta Med 67:103-7. 2001
..These findings support that CTN inhibits NO production by down-regulating iNOS expression, at least, in part through the inhibition of I kappa Bs' phosphorylation and degradation, which are essential for the activation of NF-kappa B...
- Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice
Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
Int J Cancer 124:264-71. 2009
- Antitumor activity of extract of Zingiber aromaticum and its bioactive sesquiterpenoid zerumbone
CSIRO Health Sciences and Nutrition, PO Box 10041, Kintore Avenue, Adelaide DC, South Australia 5000
Nutr Cancer 45:218-25. 2003
..Zerumbone is effective as an anticancer agent, possibly by its apoptosis-inducing and antiproliferative influences. This latter possibility is currently being investigated...
- CYP15A1, the cytochrome P450 that catalyzes epoxidation of methyl farnesoate to juvenile hormone III in cockroach corpora allata
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 101:4024-9. 2004
..Heterologously expressed CYP15A1 from D. punctata or its ortholog from economically important species may be useful in the design and screening of selective insect control agents...
- Metabolic engineering to produce sesquiterpenes in yeast
Beth E Jackson
Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005, USA
Org Lett 5:1629-32. 2003
reaction: see text] Presented here is a metabolically engineered yeast strain that produces sesquiterpenes. Epi-cedrol synthase expressed in a native yeast strain converted endogenous farnesyl pyrophosphate to 90 microg/L epi-cedrol...
- Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
Department of Surgery, Indiana University School of Medicine, Indianapolis 46202, USA
Oncogene 23:7330-44. 2004
..These results identify a new antitumor activity of parthenolide, which can be exploited to reverse resistance of cancer cells to TRAIL, particularly those with elevated XIAP levels...
- Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells
Department of Community, Occupational and Family Medicine, Faculty of Medicine MD3, National University of Singapore, 16 Medical Drive, Singapore 117597, Republic of Singapore
Carcinogenesis 25:2191-9. 2004
..It is thus believed that suppressed NF-kappaB activation and sustained JNK activation contribute to the sensitization effect of PN to TNF-alpha-mediated cell death in human cancer cells...
- Redirection of flux through the FPP branch-point in Saccharomyces cerevisiae by down-regulating squalene synthase
Eric M Paradise
Department of Chemical Engineering, University of California, Berkeley, California 94720, USA
Biotechnol Bioeng 100:371-8. 2008
..The levels of these three metabolites were dependent not only upon the level of ERG9 repression, but also the timing of its repression relative to the induction of ADS and genes responsible for enhancing flux to FPP...
- The sesquiterpene hydrocarbons of maize (Zea mays) form five groups with distinct developmental and organ-specific distributions
Tobias G Köllner
Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, D 07745 Jena, Germany
Phytochemistry 65:1895-902. 2004
..Approximately 25% of the stored pool was found to be released from young seedlings per hour. The individual sesquiterpenes varied extensively in their abundance among different organs and developmental stages...
- Systemic root signalling in a belowground, volatile-mediated tritrophic interaction
FARCE Laboratory, University of Neuchatel, Rue Emile Argand 11, 2000 Neuchatel, Switzerland
Plant Cell Environ 34:1267-75. 2011
..In belowground olfactometers, the nematodes were significantly more attracted towards local feeding sites than systemically induced roots. The possible advantages and disadvantages of systemic volatile signalling in roots are discussed...
- The major volatile organic compound emitted from Arabidopsis thaliana flowers, the sesquiterpene (E)-β-caryophyllene, is a defense against a bacterial pathogen
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061, USA
New Phytol 193:997-1008. 2012
..E)-β-Caryophyllene thus appears to serve as a defense against pathogens that invade floral tissues and, like other floral volatiles, may play multiple roles in defense and pollinator attraction...