norbornanes

Summary

Top Publications

  1. ncbi Scavenge-ROMP-filter: a facile strategy for soluble scavenging via norbornenyl tagging of electrophilic Reagents
    Joel D Moore
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    Org Lett 4:1847-9. 2002
  2. pmc Cross-linking and degradation of step-growth hydrogels formed by thiol-ene photoclick chemistry
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 13:2003-12. 2012
  3. ncbi A 1,3-Diaza-Claisen rearrangement that affords guanidines
    Amy M Bowser
    Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
    Org Lett 6:3409-12. 2004
  4. ncbi Supramolecular catalysis at work: diastereoselective synthesis of a molecular bowl with dynamic inner space
    Zhiqing Yan
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    J Org Chem 73:355-63. 2008
  5. ncbi New norbornyl derivatives as woody fragrant materials
    Agnès Muratore
    Mane S A, Chemistry Research Center, 620 route de Grasse, F 06620 Le Bar sur Loup
    Chem Biodivers 5:1099-114. 2008
  6. ncbi Chiral polycyclic ketones via desymmetrization of dihaloolefins
    Giuseppe Borsato
    Dipartimento di Scienze Ambientali and Dipartimento di Chimica, Universita Ca Foscari di Venezia, Dorsoduro 2137, I 30123 Venezia, Italy
    J Org Chem 72:4272-5. 2007
  7. ncbi Asymmetric electrophilic amination of various carbon nucleophiles with enantiomerically pure chiral N-h oxaziridines derived from camphor and fenchone
    Philip C Bulman Page
    Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, England
    J Org Chem 67:7787-96. 2002
  8. ncbi Synthesis and activity studies of analogues of the rat selective toxicant norbormide
    David Rennison
    Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland, New Zealand
    Bioorg Med Chem 15:2963-74. 2007
  9. ncbi Fenchone, camphor, 2-methylenefenchone and 2-methylenecamphor: a vibrational circular dichroism study
    Giovanna Longhi
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, Viale Europa 11, 25123 Brescia, Italy
    J Phys Chem A 110:4958-68. 2006
  10. ncbi Increased polymer length of oligopeptide-substituted polynorbornenes with LiCl
    Kenny S Roberts
    Department of Chemistry, State University of New York, Stony Brook, New York 11794 3400, USA
    J Org Chem 68:2020-3. 2003

Research Grants

  1. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
  2. Inhibitors of Hedgehog Signaling For Brain Cancer Chemotherapy
    JEFFREY D contact WINKLER; Fiscal Year: 2010
  3. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
  4. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
  5. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
  6. Thiol-Ene Polymers as Dental Restorative Materials
    NEIL CRAMER; Fiscal Year: 2006
  7. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
  8. COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTION
    Frank Carroll; Fiscal Year: 2007
  9. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
  10. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003

Detail Information

Publications164 found, 100 shown here

  1. ncbi Scavenge-ROMP-filter: a facile strategy for soluble scavenging via norbornenyl tagging of electrophilic Reagents
    Joel D Moore
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    Org Lett 4:1847-9. 2002
    ..This process yields a polymer that can be precipitated with methanol or ether/hexane, leaving products in excellent yield and purity...
  2. pmc Cross-linking and degradation of step-growth hydrogels formed by thiol-ene photoclick chemistry
    Han Shih
    Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University at Indianapolis, Indianapolis, Indiana 46202, United States
    Biomacromolecules 13:2003-12. 2012
    ..In addition, we incorporated a chymotrypsin-sensitive peptide as part of the cross-linkers to tune the mode of gel degradation from bulk degradation to surface erosion...
  3. ncbi A 1,3-Diaza-Claisen rearrangement that affords guanidines
    Amy M Bowser
    Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
    Org Lett 6:3409-12. 2004
    ..reaction: see text] N-Alkyl-N'-tosylthioureas activated by EDCI react with azanorbonenes at room temperature through a 1,3-diaza-Claisen rearrangement, affording highly substituted, bicyclic guanidines in moderate to good yields...
  4. ncbi Supramolecular catalysis at work: diastereoselective synthesis of a molecular bowl with dynamic inner space
    Zhiqing Yan
    Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA
    J Org Chem 73:355-63. 2008
    ..Ultimately, Ag(I) has been shown to assist the diastereoselective formation of 1syn, lending support to the notion of template-directed synthesis...
  5. ncbi New norbornyl derivatives as woody fragrant materials
    Agnès Muratore
    Mane S A, Chemistry Research Center, 620 route de Grasse, F 06620 Le Bar sur Loup
    Chem Biodivers 5:1099-114. 2008
    ..Employing this new ketone as starting material, derivatives with new woody odor notes as well as attempts to obtain ambery-musky odorants are reported...
  6. ncbi Chiral polycyclic ketones via desymmetrization of dihaloolefins
    Giuseppe Borsato
    Dipartimento di Scienze Ambientali and Dipartimento di Chimica, Universita Ca Foscari di Venezia, Dorsoduro 2137, I 30123 Venezia, Italy
    J Org Chem 72:4272-5. 2007
    ..The generality of this desymmetrization with (-)-ephedrine was tested with dibromonorbornadiene 2c and other substituted dichloronorbornadienes...
  7. ncbi Asymmetric electrophilic amination of various carbon nucleophiles with enantiomerically pure chiral N-h oxaziridines derived from camphor and fenchone
    Philip C Bulman Page
    Department of Chemistry, Loughborough University, Leicestershire LE11 3TU, England
    J Org Chem 67:7787-96. 2002
    ..One of the ester or nitrile units in the substrate usually undergoes hydrolysis; a cyclic mechanism is proposed to account for this observation...
  8. ncbi Synthesis and activity studies of analogues of the rat selective toxicant norbormide
    David Rennison
    Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland, New Zealand
    Bioorg Med Chem 15:2963-74. 2007
    ..Their synthesis and biological evaluation (vasoconstriction, vasodilation, mitochondrial dysfunction, cardiotoxicity and lethality) is described...
  9. ncbi Fenchone, camphor, 2-methylenefenchone and 2-methylenecamphor: a vibrational circular dichroism study
    Giovanna Longhi
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, Viale Europa 11, 25123 Brescia, Italy
    J Phys Chem A 110:4958-68. 2006
    ....
  10. ncbi Increased polymer length of oligopeptide-substituted polynorbornenes with LiCl
    Kenny S Roberts
    Department of Chemistry, State University of New York, Stony Brook, New York 11794 3400, USA
    J Org Chem 68:2020-3. 2003
    ..This methodology should significantly expand the variety of polymers that may be prepared by ROMP and be of general use with norbornyl oligopeptides of any sequence...
  11. ncbi Ethene/norbornene copolymerization by [MeSi(3-(tert)BuCp) (N(tert)Bu)]TiCl2/MAO-catalyst
    Phu Dennis Tran
    Institute of Technical and Macromolecular Chemistry, University of Hamburg, Germany
    J Zhejiang Univ Sci 4:121-30. 2003
    ..High copolymerization values r(E) and high alternation are determined. The number of isotactic alternating sequences is much higher than that of the syndiotactic alternating sequences...
  12. ncbi Ruthenium-catalyzed [2 + 2] cycloadditions between 7-substituted norbornadienes and alkynes: an experimental and theoretical study
    Robert W Jordan
    Guelph Waterloo Centre for Graduate Work in Chemistry and Biochemistry, Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1
    J Org Chem 69:8467-74. 2004
    ..3-9.8 kcal/mol. The activation energy relative to the metallacyclopentene for the reductive elimination step is much higher than for the oxidative addition step (in the range of 25.9-27.6 kcal/mol)...
  13. ncbi Regiodivergent Baeyer-Villiger oxidation of fused ketones by recombinant whole-cell biocatalysts
    Marko D Mihovilovic
    Institute of Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9 163 OC, 1060 Vienna, Austria
    ChemSusChem 1:143-8. 2008
    ..The complementary behavior of enzymes was found to correlate with our previous observation of clustering of cycloketone-oxidizing proteins into two distinct clusters based on phylogenetic relationship and biocatalyst performance...
  14. ncbi Stereochemistry of beta-deuterium isotope effects on amine basicity
    Charles L Perrin
    Department of Chemistry 0358, University of California, San Diego, La Jolla, California 92093 0358, USA
    J Am Chem Soc 127:9641-7. 2005
    ..The isotope effect is attributed to a lowered zero-point energy of a C-H bond adjacent to an amine nitrogen, arising from delocalization of either a syn or an anti lone pair, and with no detectable angle-independent inductive effect...
  15. pmc Catalytic hydroamination of alkynes and norbornene with neutral and cationic tantalum imido complexes
    Laura L Anderson
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Org Lett 6:2519-22. 2004
    ..Factors affecting catalyst activity and selectivity are discussed along with mechanistic insights gained from stoichiometric reactions...
  16. ncbi Remote electronic effects in the rhodium-catalyzed nucleophilic ring opening of oxabenzonorbornadienes
    Mark Lautens
    Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5H 3H6
    J Org Chem 67:8043-53. 2002
    ..Post ring-opening manipulations of functional groups in the dihydronaphthalene products were shown to give efficient access to mono- and diamine tetrahydronaphthalene building blocks...
  17. ncbi Surface-initiated, ring-opening metathesis polymerization: formation of diblock copolymer brushes and solvent-dependent morphological changes
    Bokyung Kong
    Department of Chemistry and School of Molecular Science, Center for Molecular Design and Synthesis, KAIST, Daejeon, Korea
    Langmuir 23:6761-5. 2007
    ..After the formation, the polymer-grafted substrates were immersed in various solvents, and the selective swelling characteristics of polymer brushes were investigated by atomic force microscopy...
  18. ncbi Chiral norbornadienes as efficient ligands for the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to fumaric and maleic compounds
    Ryo Shintani
    Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606 8502, Japan
    Org Lett 6:3425-7. 2004
    ..While phosphorus-based chiral ligands fail to induce high stereoselectivity, chiral norbornadiene ligands have proved to be uniquely effective to achieve high enantioselectivity in these 1,4-addition reactions...
  19. ncbi ROMP-generated oligomeric sulfonyl chlorides as versatile soluble scavenging agents
    Joel D Moore
    Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045 7582, USA
    Org Lett 5:105-7. 2003
    ..Following the scavenging event, these oligomers are precipitated with ethyl acetate leaving products in excellent yield and purity...
  20. ncbi Shape-tunable polymer nodules grown from liposomes via ring-opening metathesis polymerization
    Nathalie Jarroux
    Laboratoire de Physicochimie Curie, Institut Curie, UMR 168, 11 rue Pierre et Marie Curie, 75231 Paris Cedex 05, France
    J Am Chem Soc 126:15958-9. 2004
    ..We obtain nodules of polymer that can grow up to tens of micrometers, unveiling new efficient possibilities of polymerization from a membrane in an aqueous solution...
  21. ncbi Tuning the hemolytic and antibacterial activities of amphiphilic polynorbornene derivatives
    M Firat Ilker
    Department of Polymer Science and Engineering, University of Massachusetts Amherst, Amherst, Massachusetts 01003, USA
    J Am Chem Soc 126:15870-5. 2004
    ..For appropriate monomer composition, selectivity against bacteria versus human red blood cells was determined to be over 100...
  22. ncbi Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain
    K C Nicolaou
    Department of Chemistry and Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Angew Chem Int Ed Engl 44:3443-7. 2005
  23. ncbi Asymmetric Diels-Alder reactions of chiral cyclopropylidene imide dienophiles: preparation of gem-dimethyl- and spirocyclopropane norbornyl carboxylic acids
    Jeffrey T Kuethe
    Department of Process Research, Merck and Co, Inc, P O Box 2000, Rahway, New Jersey 07065, USA
    J Org Chem 71:2192-5. 2006
    ..The key transformation involved the unprecedented asymmetric Diels-Alder reaction of highly reactive beta,beta-cyclopropyl-alpha,beta-unstaturated N-acyloxazolidinones with cyclopentadiene affording the adducts in high yield and de...
  24. ncbi Identification and structure-activity relationship studies of 3-methylene-2-norbornanone as potent anti-proliferative agents presumably working through p53 mediated apoptosis
    N Laxma Reddy
    Ricerca Biosciences, 7528 Auburn Road, Concord, OH 44077, USA
    Bioorg Med Chem Lett 14:5645-9. 2004
    ..Further, compound 3 and its analogs showed refolding of mutant p53 protein comparable to their anti-proliferative activities suggesting possible interaction with mutant p53 protein...
  25. ncbi Stabilization of a kinetically favored nanostructure: surface ROMP of self-assembled conductive nanocoils from a norbornene-appended hexa-peri-hexabenzocoronene
    Takuya Yamamoto
    ERATO SORST Nanospace Project, Japan Science and Technology Agency JST, National Museum of Emerging Science and Innovation, 2 41 Aomi, Koto ku, Tokyo 135 0064, Japan
    J Am Chem Soc 128:14337-40. 2006
    ..The polymerized nanocoils show an electroconductivity of 1 x 10(-)(4) S cm(-)(1) upon doping with I(2), while the nonpolymerized nanocoils are disrupted upon being doped...
  26. ncbi Steric and electronic factors influencing recognition by a simple, charge neutral norbornene based anion receptor
    Adam J Lowe
    School of Life and Environmental Sciences, Deakin University, Geelong, Vic, Australia
    Org Biomol Chem 5:1343-6. 2007
    ....
  27. pmc Specific inhibition of kynurenate synthesis enhances extracellular dopamine levels in the rodent striatum
    L Amori
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, P O Box 21247, Baltimore, MD 21228, USA
    Neuroscience 159:196-203. 2009
    ..Taken together, these results provide further support for the concept that KAT II is a critical determinant of functionally relevant KYNA fluctuations in the rodent striatum...
  28. ncbi Determination of 5-ethylidene-2-norbornene in industrial emission
    Fabio Camerini
    Italian National Research Council Institute for Atmospheric Pollution Research CNR IIA, Via Salaria Km 29, 300 00015 Monterotondo, Rome, Italy
    Environ Sci Pollut Res Int 20:4881-5. 2013
    ..The method could be extended to other reactive compounds of the same class...
  29. ncbi Polymer-DNA hybrids as electrochemical probes for the detection of DNA
    Julianne M Gibbs
    Department of Chemistry and Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208 3113, USA
    J Am Chem Soc 127:1170-8. 2005
    ..Significantly, single-base mismatches could be easily detected using two distinct block copolymers as dual-channel detection probes in an electrochemical DNA detection format...
  30. ncbi Pd(II)-catalyzed regioselective 2-alkylation of indoles via a norbornene-mediated C-H activation: mechanism and applications
    Lei Jiao
    Lehrstuhl für Organische Chemie I and Catalysis Research Center, Technische Universitat Munchen, Lichtenbergstrasse 4, 85747 Garching, Germany
    J Am Chem Soc 134:14563-72. 2012
    ....
  31. ncbi Diastereochemical differentiation of some cyclic and bicyclic beta-amino acids, via the kinetic method
    Anna R M Hyyryläinen
    Department of Chemistry, University of Joensuu, Joensuu, Finland
    J Am Soc Mass Spectrom 20:34-41. 2009
    ..Ab initio and hybrid density functional theory calculations were performed to clarify the results obtained by mass spectrometry...
  32. ncbi Ring-opening metathesis polymerization-based recyclable magnetic acylation reagents
    Quirin M Kainz
    Institute for Organic Chemistry, University of Regensburg, Universitätsstr 31, 93053 Regensburg, Germany
    ChemSusChem 6:721-9. 2013
    ..The spent resins were successfully re-acylated by acid chlorides, anhydrides, and carboxylic acids and reused for up to five consecutive cycles without considerable loss of activity...
  33. ncbi Assessing the molecular basis for rat-selective induction of the mitochondrial permeability transition by norbormide
    Alessandra Zulian
    Department of Pharmacology and Anesthesiology Pharmacology Division, University of Padova, Padova, Italy
    Biochim Biophys Acta 1767:980-8. 2007
    ..The species-selectivity may depend on the unique properties of a transport system allowing drug internalisation in rat mitochondria...
  34. ncbi Prodrugs of N-dicarboximide derivatives of the rat selective toxicant norbormide
    David Rennison
    School of Chemical Sciences, The University of Auckland, New Zealand
    Bioorg Med Chem 21:5886-99. 2013
    ..Moreover, prodrug 25 was found to be largely accepted by rats in a choice trial, resulting in high mortality...
  35. ncbi Synthesis of novel purine-based coxsackievirus inhibitors bearing polycylic substituents at the N-9 position
    Milan Dejmek
    Institute of Organic Chemistry and Biochemistry, Gilead Sciences and IOCB Research Centre, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Arch Pharm (Weinheim) 347:478-85. 2014
    ..The series includes norbornanes, bicyclo[2.2.2]octanes, and bicyclo[3.2.1]octanes attached at the bridgehead position as well as bicyclo[3.1...
  36. ncbi Approaches to syn-7-substituted 2-azanorbornanes as potential nicotinic agonists; synthesis of syn- and anti-isoepibatidine
    John R Malpass
    Department of Chemistry, University of Leicester, Leicester LE1 7RH, United Kingdom
    Org Lett 7:2759-62. 2005
    ..Facial selectivity in attack on 7-keto-2-azanorbornanes depends heavily on the N-protecting group leading to the first syn-7-hydroxy-2-azabicyclo[2.2.1]heptane derivative...
  37. ncbi A new access route to functionalized cispentacins from norbornene β-amino acids
    Lorand Kiss
    Institute of Pharmaceutical Chemistry, University of Szeged, 6720 Szeged, Eotvos u 6, Hungary
    Chemistry 19:2102-7. 2013
    ..The synthesis involves olefinic bond functionalization by dihydroxylation followed by oxidative ring cleavage and transformation of the dialdehyde intermediate through a Wittig reaction...
  38. ncbi Electronic regioselectivity of diarylalkynes in cobalt-mediated Pauson-Khand reaction: an experimental and computational study with para- and meta-substituted diarylalkynes and norbornene
    Erika Fager-Jokela
    Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, A I Virtasen Aukio 1, P O Box 55, Helsinki, Finland
    J Org Chem 77:9134-47. 2012
    ..Overall, the results suggest that the polarity of an alkyne, also designated by the relative polarization of aryl α-carbons, dictates the regioselectivity in the absence of steric effects...
  39. ncbi Solid-state 13C NMR and quantum chemical investigation of metal diene complexes
    Zhiru Ma
    Departments of Chemistry, University of Utah, 201 S President s Circle, Salt Lake City, UT 84112, USA
    Magn Reson Chem 45:393-400. 2007
    ..2.1]hepta-2,5-diene (BCHD)dichlororuthenium(II) polymer...
  40. ncbi Supramolecular ABC triblock copolymers via one-pot, orthogonal self-assembly
    Si Kyung Yang
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    J Am Chem Soc 132:1637-45. 2010
    ....
  41. ncbi The norbornene mystery revealed
    Stephan N Steinmann
    Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne EPFL SB ISIC, Lausanne, Switzerland
    Chem Commun (Camb) 47:227-9. 2011
    ..e. Lewis structures). Our block-localized wavefunction analysis coupled with the computations of NMR parameters evidently supports the manifestation of a density redistribution toward an incipient retro-Diels-Alder reaction...
  42. ncbi Norbornene derived doxorubicin copolymers as drug carriers with pH responsive hydrazone linker
    Vijayakameswara Rao N
    Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, India
    Biomacromolecules 13:221-30. 2012
    ....
  43. ncbi Anticancer thiopyrano[2,3-d][1,3]thiazol-2-ones with norbornane moiety. Synthesis, cytotoxicity, physico-chemical properties, and computational studies
    Roman Lesyk
    Danylo Halytsky Lviv National Medical University, Department of Pharmaceutical, Organic and Bioorganic Chemistry, Pekarska 69, Lviv 79010, Ukraine
    Bioorg Med Chem 14:5230-40. 2006
    ..Docking and structure-activity relationship studies produced seven QSAR models with 2 or 3 variables, with correlation coefficients r2>0.9 and leave-one-out cross-validation correlation coefficients, q2>0.8...
  44. pmc A cope rearrangement-based route to hexahydroazulenes
    Curtis A Seizert
    Department of Chemistry, Washington University, Campus Box 1134, One Brookings Drive, St Louis, Missouri 63130, USA
    Org Lett 12:3472-5. 2010
    ..2-exo-Vinyl-7-alkylidenenorbornanes, readily prepared from fulvene Diels-Alder adducts, undergo smooth Cope rearrangement at elevated temperatures to produce hexahydroazulene derivatives...
  45. ncbi Synthesis of bis-peptides attached on poly[n]norbornene molecular scaffolds with well-defined relative positions and distances
    Muhong Shang
    Centre for Molecular Architecture, Central Queensland University, Rockhampton, QLD, 4702, Australia
    Mol Divers 15:541-60. 2011
    ..Chemical elaboration of bridgehead dimethyl esters of ACE products or epoxide ACE reagents was also used for peptide attachment...
  46. ncbi [Analysis on the compositions of volatile oil of Alpinia henryi with GC-MS method]
    Hua Zhen Qin
    Guangxi Traditional Chinese Medical University, Nanning 530001, China
    Zhong Yao Cai 34:1897-9. 2011
    ..To study the components of volatile oil of Alpinia henryi...
  47. ncbi Effect of various visible light photoinitiators on the polymerization and color of light-activated resins
    Hiroyuki Arikawa
    Department of Biomaterials Science, Graduate School of Medical and Dental Sciences, Kagoshima University
    Dent Mater J 28:454-60. 2009
    ..Our results indicate that the TPO photoinitiator and the violet-LED light unit may provide a useful and improved photopolymerization system for dental light-activated resins...
  48. ncbi Interactions between ethylene, gibberellin and abscisic acid regulate emergence and growth rate of adventitious roots in deepwater rice
    Bianka Steffens
    Botanisches Institut, Universitat Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Planta 223:604-12. 2006
    ..Different interactions between the same hormones may be a means to ensure proper timing of cell death and root emergence and to adjust the growth rate of emerged adventitious roots...
  49. ncbi Photoinduced intramolecular electron transfer and triplet energy transfer in a steroid-linked norbornadiene-carbazole dyad
    Li Ping Zhang
    Technical Institute of Physics and Chemistry, The Chinese Academy of Sciences, Beijing, P R China
    Chemistry 9:2763-9. 2003
    ..The long-distance intramolecular triplet energy transfer and electron transfers starting both from the singlet and triplet excited states are proposed to proceed by a through-bond mechanism...
  50. ncbi Rational design and synthesis of an orally active indolopyridone as a novel conformationally constrained cannabinoid ligand possessing antiinflammatory properties
    Stephen T Wrobleski
    Department of Discovery Chemistry, Bristol Myers Squibb, P O Box 4000, Princeton, New Jersey 08543 4000, USA
    J Med Chem 46:2110-6. 2003
    ..0 nM) and possesses antiinflammatory properties when administered orally in an in vivo murine inflammation model...
  51. ncbi Design, synthesis, and crystal structure of self-assembling norbornene (NBE)-supported two-helix bundles: a unique example of Janus helicity in the solid-state structure of NBE(Aib(5))(2)
    D Ranganathan
    Discovery Laboratory, Indian Institute of Chemical Technology, Hyderabad 500 007, India
    Biopolymers 54:249-61. 2000
    ..The helices in all the molecules are the 3(10)-type...
  52. ncbi Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue
    Lennart Bunch
    Department of Medicinal Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    J Org Chem 68:1489-95. 2003
    ....
  53. ncbi Incorporation of conformationally constrained beta-amino acids into peptides
    M North
    Department of Chemistry, King s College, Strand, London, UK
    J Pept Sci 6:301-13. 2000
    ..As an illustration of the application of this chemistry, a short, asymmetric synthesis of conformationally constrained metalloprotease inhibitors is presented...
  54. ncbi Supercritical carbon dioxide extraction and fractionation of fennel oil
    B Simándi
    Central Food Research Institute, Budapest, Hungary
    J Agric Food Chem 47:1635-40. 1999
    ..Sensory evaluation showed that the CO(2) extraction product and distilled oil were more intense in odor and taste than alcohol and hexane extracts...
  55. ncbi Carbonic anhydrase inhibitors: synthesis and inhibition against isozymes I, II and IV of topically acting antiglaucoma sulfonamides incorporating cis-5-norbornene-endo-3-carboxy-2-carboxamido moieties
    A Casini
    , Laboratorio di Chimica Inorganica e Bioinorganica, Via Gino Capponi 7, I-50121, Florence, Italy
    J Enzyme Inhib 16:113-23. 2001
    ....
  56. ncbi Substrates modulate the rate-determining step for CO binding in cytochrome P450cam (CYP101). A high-pressure stopped-flow study
    Christiane Jung
    Max Delbruck Center for Molecular Medicine, Protein Dynamics Laboratory, Berlin, Germany
    Eur J Biochem 269:2989-96. 2002
    ..In addition, subconformers have been found for the substrate-free and camphane-bound protein which show different CO binding kinetics...
  57. ncbi Changes in sodium, potassium-ATPase induced by repeated fencamfamine: the roles of cyclic AMP-dependent protein kinase and the nitric oxide-cyclic GMP pathway
    Carolina Demarchi Munhoz
    Department of Pharmacology, Institute of Biomedical Sciences, University of Sao Paulo, Avenida Prof Lineu Prestes, 1524 Cidade Universitaria, Sao Paulo 05508 900, SP, Brazil
    Neuropharmacology 45:1151-9. 2003
    ..We suggest that chronic FCF treatment is linked to a modification in Na,K-ATPase activity through the PKA and NO-cyclic GMP pathway...
  58. ncbi Catalytic asymmetric ring-opening metathesis/cross metathesis (AROM/CM) reactions. Mechanism and application to enantioselective synthesis of functionalized cyclopentanes
    D S La
    Departments of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, USA
    J Am Chem Soc 123:7767-78. 2001
    ..Although electron rich benzylidenes react more efficiently, the derived electron poor Mo complexes promote AROM/CM transformations as well; alkylidenes that bear a boron substituent are unreactive...
  59. ncbi Developing soluble polymers for high-throughput synthetic chemistry
    Carsten Spanka
    Department of Chemistry, The Scripps Research Institute and The Skaggs Institute for Chemical Biology, 10550 N Torrey Pines Rd, La Jolla, CA 92037, USA
    Comb Chem High Throughput Screen 5:233-40. 2002
    ....
  60. ncbi Alpha,gamma-diamino acids: asymmetric synthesis of new constrained 6-amino-3-azabicyclo[3.2.1]octane-6-carboxylic acids
    Francesco Caputo
    Istituto di Chimica Organica A Marchesini, Facolta di Farmacia, Universita di Milano, via Venezian 21, I 20133 Milano, Italy
    J Org Chem 71:8467-72. 2006
    ..This method provides a fast access to optically pure amino acids 8 and 9 which can be considered both alpha,gamma- and alpha,delta-diamino acids containing sterical constraints and characterized by alpha,alpha-disubstitution...
  61. ncbi Copper-free "click" modification of DNA via nitrile oxide-norbornene 1,3-dipolar cycloaddition
    Katrin Gutsmiedl
    Center for Integrative Protein Science at the Department of Chemistry and Biochemistry, Ludwig Maximilians University, Butenandtstr 5 13, 81377 Munich
    Org Lett 11:2405-8. 2009
    ..The reaction allows high density functionalization of oligodeoxyribonucleotides (ODNs) with a large variety of molecules directly on solid supports and even in synthesizers without the need for an additional catalyst...
  62. ncbi Chemical composition of vintage preban absinthe with special reference to thujone, fenchone, pinocamphone, methanol, copper, and antimony concentrations
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    J Agric Food Chem 56:3073-81. 2008
    ..Analyses of pinocamphone, fenchone, base spirits, copper, and antimony were inconspicuous. All things considered, nothing besides ethanol was found in the absinthes that was able to explain the syndrome "absinthism"...
  63. ncbi A novel one-step synthesis of imidazo[5,1-a]isoquinolines via a tandem Pd-catalyzed alkylation-direct arylation sequence
    Farnaz Jafarpour
    School of Chemistry, University College of Science, University of Tehran, P O Box 14155 6455, Tehran, Iran
    J Org Chem 74:1364-6. 2009
    ..This method provides an efficient route to a wide variety of substituted imidazo[5,1-a]isoquinolines from readily accessible N-bromoalkyl imidazoles and aryl iodides...
  64. ncbi Application of secondary alkyl halides to a domino aryl alkylation reaction for the synthesis of aromatic heterocycles
    Alena Rudolph
    Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, M5S 3H6, Canada
    J Org Chem 74:289-97. 2009
    ..The use of enantioenriched substrates has shown that this palladium-catalyzed reaction is stereospecific, proceeding with minimal erosion of ee...
  65. ncbi Alkene distortion energies and torsional effects control reactivities, and stereoselectivities of azide cycloadditions to norbornene and substituted norbornenes
    Steven A Lopez
    Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095 1569, United States
    J Org Chem 78:1778-83. 2013
    ..The stereoselectivities of reactions of norbornene derivatives are controlled primarily by torsional effects that also influence alkene pyramidalization. These reactions are distortion-accelerated...
  66. ncbi Signaling mechanisms for the selective vasoconstrictor effect of norbormide on the rat small arteries
    S Bova
    Department of Pharmacology and Anesthesiology, University of Padova, Padova, Italy
    J Pharmacol Exp Ther 296:458-63. 2001
    ..Ca2+ release from sarcoplasmic reticulum seems not involved in NRB vasoconstriction...
  67. ncbi Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor
    J A Auchampach
    Departments of Medicine Cardiology, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Pharmacol 52:846-60. 1997
    ..Although A2B receptors play a major role in the regulation of BR mast cell degranulation, multiple AR subtypes and G proteins may influence mast cell functions...
  68. ncbi Binding orientation of amphetamine and norfenfluramine analogues in the benzonorbornene and benzobicyclo[3.2.1]octane ring systems at the active site of phenylethanolamine N-methyltransferase (PNMT)
    G L Grunewald
    Department of Medicinal Chemistry, University of Kansas, Lawrence 66045
    J Med Chem 30:2191-208. 1987
    ....
  69. ncbi Asymmetric synthesis of dihydrofurans via a formal retro-Claisen photorearrangement
    Wujiong Xia
    Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, B C, Canada V6T 1Z1
    J Am Chem Soc 127:2725-30. 2005
    ....
  70. ncbi Strategies and methods for the attachment of amino acids and peptides to chiral [n]polynorbornane templates
    Frederick M Pfeffer
    Department of Chemistry, Trinity College Dublin, Dublin 2, Ireland
    Org Biomol Chem 1:1845-51. 2003
    ..The strategies employed allow a range of topologies to be accessed and a number of regioselectively addressable linkage points to be accommodated...
  71. ncbi Iridium-catalyzed asymmetric hydroalkynylation reactions of oxabenzonorbornadienes
    Jun Hu
    Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission and Ministry of Education, Yunnan University of Nationalities, Kunming, 650500, China
    Org Biomol Chem 11:814-20. 2013
    ....
  72. ncbi Chronic lithium chloride treatment has variable effects on motor behaviour and survival of mice transgenic for the Huntington's disease mutation
    Nigel I Wood
    Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD Cambridge, UK
    Brain Res Bull 61:375-83. 2003
    ..The improvement in rotarod performance suggests that lithium may improve motor symptoms as well as depression in some HD patients...
  73. pmc Genetically encoded norbornene directs site-specific cellular protein labelling via a rapid bioorthogonal reaction
    Kathrin Lang
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Chem 4:298-304. 2012
    ....
  74. ncbi Effect of binary combination of some plant-derived molluscicides with MGK-264 or piperonyl butoxide on the reproduction of the snail Lymnaea acuminata
    Priyamvada Singh
    Department of Zoology, DDU Gorakhpur University, Gorakhpur 273 009, India
    Pest Manag Sci 61:204-8. 2005
    ..Removal of the snails to fresh water after the 96-h treatments caused a significant recovery in the fecundity of L acuminata...
  75. ncbi Remote exo/endo selectivity in selective monohydrolysis of dialkyl bicyclo[2.2.1]heptane-2,3-dicarboxylate derivatives
    Satomi Niwayama
    Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409 1061, USA
    J Org Chem 75:3775-80. 2010
    ..The effect of the co-solvent we studied earlier for the selective monohydrolysis reaction was also confirmed and contributed to improvement of the yields of the half-esters...
  76. ncbi Examples of regioselective anion recognition among a family of two-, three-, and four-"armed" bis-, tris-, and tetrakis(thioureido) [n]polynorbornane hosts
    Adam J Lowe
    Research Centre for Chemistry and Biotechnology, School of Life and Environmental Sciences, Deakin University, Waurn Ponds 3217, Australia
    J Org Chem 77:8507-17. 2012
    ....
  77. ncbi Unusual emission from norbornene derived phosphonate molecule--a sensor for Fe(III) in aqueous environment
    Sourav Bhattacharya
    Polymer Research Centre, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata IISER K, India
    Nanoscale 4:6962-6. 2012
    ..Our hypothesis is further strengthened as there is no emission from NDPH1. The unusual fluorescence is utilized as a new fluorometric sensor that selectively detects Fe(III) ions...
  78. ncbi DFT and experimental exploration of intramolecular [2 + 2 + 2] cycloaddition of oxanorbornadienedicarboxylates and analogues
    Xinyao Li
    State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, 100029 Beijing, People s Republic of China
    J Org Chem 78:3039-47. 2013
    ..The intermolecular version was also evaluated in comparison with the intramolecular version. Finally, our experimental tests verified the calculational prediction of the regioselectivity and reactivity...
  79. ncbi The stereochemical outcome of allyl magnesium and indium additions to 5-substituted norbornen-7-ones and its application to cis fused carbocycle formation via ring rearrangement metathesis
    Patricia E Standen
    Department of Chemistry, Loughborough University, Leicestershire, LE11 3TU, UK
    Org Biomol Chem 10:8669-76. 2012
    ..The subsequent exposure of the addition products to metathesis conditions, in the presence of ethene, then provided cis fused[3.0.3]-carbocycles with very high regioselectivity, via a Ring Rearrangement Metathesis (RRM) transformation...
  80. ncbi Design and synthesis of prodrugs of the rat selective toxicant norbormide
    David Rennison
    Department of Chemistry, University of Auckland, 23 Symonds Street, Auckland, New Zealand
    Bioorg Med Chem 20:3997-4011. 2012
    ..Compound 19 displayed the most promising profile with respect to a delay in the onset of symptoms and was subsequently demonstrated to be significantly more palatable to rats...
  81. pmc Mutagenesis and functional studies with succinate dehydrogenase inhibitors in the wheat pathogen Mycosphaerella graminicola
    Gabriel Scalliet
    Syngenta Crop Protection Münchwilen AG, Stein, Switzerland
    PLoS ONE 7:e35429. 2012
    ....
  82. ncbi Norbormide enhances late steps of steroid-hormone synthesis in rat and mouse adrenal cortex
    Giuliano Neri
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    J Steroid Biochem Mol Biol 84:479-83. 2003
    ..The mechanism underlying the selective activating action of norbormide on 11beta- and 18-hydroxylation remains to be investigated...
  83. ncbi Catalytic functionalization of unactivated primary C-H bonds directed by an alcohol
    Eric M Simmons
    Department of Chemistry, University of Illinois, Urbana, Illinois 61801, USA
    Nature 483:70-3. 2012
    ....
  84. pmc Synthesis and evaluation of a series of 1,2,4,5-tetrazines for bioorthogonal conjugation
    Mark R Karver
    Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, MA 02114, USA
    Bioconjug Chem 22:2263-70. 2011
    ..One promising, highly stable, and water-soluble derivative was used in pretargeted cancer cell labeling studies, confirming its utility as a bioorthogonal moiety...
  85. ncbi The use of an emulsion templated microcellular poly(dicyclopentadiene-co-norbornene) membrane as a separator in lithium-ion batteries
    Sebastijan Kovačič
    Graz University of Technology, Institute for Chemistry and Technology of Materials, Stremayrgasse 9, A 8010 Graz, Austria
    Macromol Rapid Commun 34:581-7. 2013
    ..These results demonstrate that a potential weakness in the newly disclosed separator, namely residual double bonds present in the polymer network, does not limit the use of this material as a separator in lithium-ion batteries...
  86. ncbi NIR-VCD, vibrational circular dichroism in the near-infrared: experiments, theory and calculations
    Sergio Abbate
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    Chirality 21:E242-52. 2009
    ..We hope to stimulate interest in this still scarcely explored spectroscopy of chiral molecules...
  87. ncbi Comparative analysis of IR and vibrational circular dichroism spectra for a series of camphor-related molecules
    Sergio Abbate
    Dipartimento di Scienze Biomediche e Biotecnologie, Universita di Brescia, 25123 Brescia, Italy
    J Phys Chem A 113:11390-405. 2009
    ..A discussion is provided as to the usability of the introduced algorithms...
  88. pmc Transport of L-carnitine in human corneal and conjunctival epithelial cells
    Shunjiang Xu
    Brien Holden Vision Institute, The University of New South Wales, Sydney, NSW, Australia
    Mol Vis 16:1823-31. 2010
    ..The present study aimed to examine the characteristics of L-carnitine transporters in cultured human limbal corneal (HCLE) and conjunctival epithelial (HCjE) cells...
  89. pmc Investigation of thiol-ene and thiol-ene-methacrylate based resins as dental restorative materials
    NEIL B CRAMER
    Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA
    Dent Mater 26:21-8. 2010
    ..The objective of this work was to evaluate thiol-norbornene and thiol-ene-methacrylate systems as the resin phase of dental restorative materials and demonstrate their superior performance as compared to dimethacrylate materials...
  90. ncbi Ring-opening metathesis polymerization-based synthesis of ICG-containing amphiphilic triblock copolymers for in vivo tumor imaging
    Koji Miki
    Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo ku, Kyoto, Japan
    Bioconjug Chem 20:511-7. 2009
    ..In addition, the spherical assemblies of water-soluble polymers accumulated in a tumor cell over two weeks...
  91. ncbi Alternating ring-opening metathesis copolymerization of amino acid derived norbornene monomers carrying nonprotected carboxy and amino groups based on acid-base interaction
    Sutthira Sutthasupa
    Department of Polymer Chemistry, Graduate School of Engineering, Kyoto University, Katsura Campus, Nishikyo ku, Kyoto 615 8510, Japan
    J Am Chem Soc 131:10546-51. 2009
    ..It is considered that alternating copolymerization is brought about by the acid-base interaction between the monomers and/or between the propagating polymer end and the incoming monomer...
  92. ncbi Pharmacological evaluation of 2-amino-6(7)- and 9-amino-6-trifluoromethylbenzonorbornenes, the conformationally rigid analogues of norfenfluramine in mice
    N M Gray
    Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612
    Gen Pharmacol 24:1343-9. 1993
    ..5. Only the exo-2-amino isomer exhibited analgesic potency similar to that of fenfluramine. Furthermore all of these compounds were capable of enhancing the analgesic activity of morphine...
  93. ncbi Influence of the solvent ability to form hydrogen bonds in the crystal structure of ([3beta,5beta,7alpha,12alpha]-3[(norbornyl-2-acetyl)-amino]-7,12-dihydroxycholan-24-oic acid (a norbornyl derivative of cholic acid)
    Javier Miragaya
    Departamento de Quimica Fisica, Facultad de Ciencias, Universidad de Santiago de Compostela, Lugo, Spain
    Steroids 74:735-41. 2009
    ..The side chain has a ttti conformation in the two orthorhombic crystals, and a tgtg one in the monoclinic crystal...
  94. ncbi Calculation of electronic circular dichroism spectra with time-dependent double-hybrid density functional theory
    Lars Goerigk
    Theoretische Organische Chemie, Organisch Chemisches Institut, Universitat Munster, Corrensstrasse 40, D 48149 Munster, Germany
    J Phys Chem A 113:767-76. 2009
    ..Therefore, we can recommend the use of the new double-hybrid approach for the computation of CD and the prediction of absolute configurations of chiral molecules...
  95. pmc A direct route to cyclic organic nanostructures via ring-expansion metathesis polymerization of a dendronized macromonomer
    Andrew J Boydston
    Arnold and Mabel Beckman Laboratory of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
    J Am Chem Soc 131:5388-9. 2009
    ..The strategy provides a direct, efficient route to nanoscale rings in a single operation. AFM imaging confirmed toroidal features having diameters of ca. 35-40 nm...
  96. ncbi Vapor emissions resulting from Nd:YAG laser interaction with tooth structure
    S C Gelskey
    Department of Dental Diagnostic and Surgical Sciences, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada
    Dent Mater 14:453-7. 1998
    ..Odors resulting from laser irradiation have been reported, but the nature and toxicity of associated decomposition vapors is unknown and the health consequences of their inhalation have not yet been studied...
  97. ncbi Norbornene-constrained cyclic peptides with hairpin architecture: design, synthesis, conformation, and membrane ion transport
    D Ranganathan
    Discovery Laboratory, Indian Institute of Chemical Technology, and Centre for Cellular and Molecular Biology, Hyderabad 500 007, India
    J Org Chem 65:365-74. 2000
    ....
  98. ncbi Heterogeneous C-C coupling and polymerization catalysts prepared by ROMP
    Michael R Buchmeiser
    Institute of Analytical Chemistry and Radiochemistry, University of Innsbruck, Innrain 52 a, Austria
    Bioorg Med Chem Lett 12:1837-40. 2002
    ..The general concept for the synthesis of these supports will be outlined in detailed...
  99. pmc Time-dependent fifth-order bands in nominally third-order 2D IR vibrational echo spectra
    Megan C Thielges
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Phys Chem A 115:9714-23. 2011
    ....
  100. ncbi Hydride mobility in trinuclear sulfido clusters with the core [Rh3(μ-H)(μ3-S)2]: molecular models for hydrogen migration on metal sulfide hydrotreating catalysts
    M Victoria Jiménez
    Departamento de Quimica Inorganica, Instituto Universitario de Catalisis Homogenea, Instituto de Ciencia de Materiales de Aragon, Universidad de Zaragoza C S I C 50009 Zaragoza, Spain
    Chemistry 17:8115-28. 2011
    ....
  101. ncbi Stereoselective inhibition of cholesterol esterase by enantiomers of exo- and endo-2-norbornyl-N-n-butylcarbamates
    Ming Cheng Lin
    Department of Internal Medicine, Chung Shan Medical University Hospital, School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
    Protein J 30:220-7. 2011
    ..6 times more potent than the R-enantiomer. The enzyme-inhibitor complex models have been proposed to explain these different enantioselectivities...

Research Grants14

  1. NOVEL PHARMACOTHERAPIES FOR COCAINE DEPENDENCE
    Frank Carroll; Fiscal Year: 2001
    ..An ideal candidate compound would not only have efficacy in the preclinical models but would be safe, orally active, and potent, would not show tolerance or sensitization, and if abusable, would be less so than cocaine. ..
  2. Inhibitors of Hedgehog Signaling For Brain Cancer Chemotherapy
    JEFFREY D contact WINKLER; Fiscal Year: 2010
    ..The studies outlined herein therefore hold the promise of developing important new tools in cancer biology and new drug candidates for the treatment of brain cancers. ..
  3. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  4. NOVEL PHARMACOTHERAPY FOR TREATMENT OF COCAINE ADDICTION
    Frank Carroll; Fiscal Year: 2008
    ..abstract_text> ..
  5. Design and Development of Pharmacotherapies for Treating Stimulant Abuse
    Frank Ivy Carroll; Fiscal Year: 2010
    ..3) To continue on a limited basis our development of selected 3-phenyltropane analogs as second-generation pharmacotherapies to treat cocaine addiction. ..
  6. Thiol-Ene Polymers as Dental Restorative Materials
    NEIL CRAMER; Fiscal Year: 2006
    ..The compatibility of monomer formulations with filler particles and the properties of filled systems will be evaluated. Biocompatibility of the new dental restorative materials will also be assessed. ..
  7. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  8. COCAINE: A STUDY OF THE BIOCHEMICAL MECHANISM OF ACTION
    Frank Carroll; Fiscal Year: 2007
    ..abstract_text> ..
  9. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  10. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003
    ..abstract_text> ..
  11. CYTOMIMETIC ORGANIC CHEMISTRY
    FREDRIC MENGER; Fiscal Year: 2007
    ....
  12. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..abstract_text> ..
  13. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  14. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..