tetradecanoylphorbol acetate

Summary

Summary: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.

Top Publications

  1. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
  2. ncbi Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms
    Hyun Ji Cho
    Department of Pathology, Catholic University of Daegu School of Medicine, 3056 6, Daemyung 4 dong, Nam Gu, Daegu 705 718, Korea
    Carcinogenesis 28:1104-10. 2007
  3. ncbi Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    J A Le Good
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 281:2042-5. 1998
  4. pmc Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase
    A M Whalen
    Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309, USA
    Mol Cell Biol 17:1947-58. 1997
  5. ncbi Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
  6. ncbi Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells
    Isabel Conde
    Department of Cellular and Molecular Medicine, Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Eur J Haematol 84:430-40. 2010
  7. ncbi A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells
    R Herrera
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Exp Cell Res 238:407-14. 1998
  8. pmc Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 18:176-88. 2007
  9. ncbi cPLA2 is phosphorylated and activated by MAP kinase
    L L Lin
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 72:269-78. 1993
  10. ncbi The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells
    Kuo Hua Lee
    Hsin Chu Branch Station, Council of Agriculture TLI, Hsin Chu, Taiwan
    Toxicol Lett 194:42-9. 2010

Research Grants

  1. PHOSPHORYLATION OF THE GLUCOSE TRANSPORTER BY INSULIN
    David Sacks; Fiscal Year: 1991
  2. NITRIC OXIDE AND TUMOR PROMOTION
    Fredika Robertson; Fiscal Year: 2000
  3. REGULATION OF PGHS-2 SYNTHESIS--ROLE OF LIPID MEDIATORS
    LARRY DANIEL; Fiscal Year: 2000
  4. HPV DIFFERENTIATION DEPENDENT REPLICATION
    Craig Meyers; Fiscal Year: 1999
  5. Ceramide synthase as a therapy target in prostate cancer
    Adriana Haimovitz Friedman; Fiscal Year: 2009
  6. Chemopreventive effects of sarcodiol on skin cancer
    Hesham Fahmy; Fiscal Year: 2009
  7. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
  8. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005
  9. Identification of a new protein that binds Src and PKC
    STEPHEN SOLTOFF; Fiscal Year: 2004
  10. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2004

Detail Information

Publications291 found, 100 shown here

  1. pmc Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands
    Umut Sahin
    Cell Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, Box 368, 1275 York Avenue, New York, NY 10021, USA
    J Cell Biol 164:769-79. 2004
    ..Identification of EGFR ligand sheddases is a crucial step toward understanding the mechanism underlying ectodomain release, and has implications for designing novel inhibitors of EGFR-dependent tumors...
  2. ncbi Ascofuranone suppresses PMA-mediated matrix metalloproteinase-9 gene activation through the Ras/Raf/MEK/ERK- and Ap1-dependent mechanisms
    Hyun Ji Cho
    Department of Pathology, Catholic University of Daegu School of Medicine, 3056 6, Daemyung 4 dong, Nam Gu, Daegu 705 718, Korea
    Carcinogenesis 28:1104-10. 2007
    ..These results suggest that the suppression of MMP-9 expression, at least in part, contributes to the antitumor activity of ascofuranone...
  3. ncbi Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
    J A Le Good
    Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
    Science 281:2042-5. 1998
    ..The activation loop phosphorylation of PKCdelta in response to serum stimulation of cells was PI 3-kinase-dependent and was enhanced by PDK1 coexpression...
  4. pmc Megakaryocytic differentiation induced by constitutive activation of mitogen-activated protein kinase kinase
    A M Whalen
    Department of Chemistry and Biochemistry, University of Colorado, Boulder 80309, USA
    Mol Cell Biol 17:1947-58. 1997
    ....
  5. ncbi Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis
    Howard F Tiano
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cancer Res 62:3395-401. 2002
    ..Thus, both COX-1 and COX-2 have roles in keratinocyte differentiation, and we propose that the absence of either isoform causes premature terminal differentiation of initiated keratinocytes and reduced tumor formation...
  6. ncbi Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells
    Isabel Conde
    Department of Cellular and Molecular Medicine, Centro de Investigaciones Biologicas CSIC, Madrid, Spain
    Eur J Haematol 84:430-40. 2010
    ..The results indicate that a precise orchestration of signals, including ERK1/2 and p38 MAPKs as well as PI3K pathway, is necessary for acquisition of features of mature MKs...
  7. ncbi A role for the MEK/MAPK pathway in PMA-induced cell cycle arrest: modulation of megakaryocytic differentiation of K562 cells
    R Herrera
    Department of Cell Biology, Parke Davis Pharmaceutical Research Division of Warner Lambert Company, Ann Arbor, Michigan 48105, USA
    Exp Cell Res 238:407-14. 1998
    ....
  8. pmc Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx
    Keisuke Horiuchi
    Arthritis and Tissue Degeneration Program, Hospital for Special Surgery, New York, NY 10021, USA
    Mol Biol Cell 18:176-88. 2007
    ....
  9. ncbi cPLA2 is phosphorylated and activated by MAP kinase
    L L Lin
    Genetics Institute, Small Molecule Drug Discovery Group, Cambridge, Massachusetts 02140
    Cell 72:269-78. 1993
    ..Taken together, these data indicate that MAP kinase mediates, at least in part, the agonist-induced activation of cPLA2...
  10. ncbi The inhibitory effect of hesperidin on tumor cell invasiveness occurs via suppression of activator protein 1 and nuclear factor-kappaB in human hepatocellular carcinoma cells
    Kuo Hua Lee
    Hsin Chu Branch Station, Council of Agriculture TLI, Hsin Chu, Taiwan
    Toxicol Lett 194:42-9. 2010
    ..In conclusion, Hesperidin might be a potent antiinvasive agent that suppresses the MMP-9 enzymatic activity via NF-kappaB an AP-1 signaling pathway...
  11. pmc Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion
    M R Young
    Basic Research Laboratory, National Cancer Institute, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 96:9827-32. 1999
    ..We conclude that transactivation of a subset of AP-1-dependent genes is required for tumor promotion and may be targeted for cancer prevention...
  12. ncbi Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in mice
    G Kalyan Kumar
    Post Graduate Research Center, Department of Plant Biology and Biotechnology, Presidency College, Chennai, Tamil Nadu, India
    Eur J Pharmacol 662:63-9. 2011
    ....
  13. pmc Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells
    Xuezhu Feng
    Genome Center of Wisconsin, University of Wisconsin Madison, Madison, WI, USA
    Stem Cells 30:461-70. 2012
    ..We further confirmed that this differentiation is through the activation of protein kinase C (PKC) pathway and demonstrated that a particular PKC subtype, PKC-δ, is most responsible for this transition...
  14. pmc Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53
    Jasmine George
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, Uttar Pradesh, India
    PLoS ONE 6:e23395. 2011
    ..This promising combination should be examined in therapeutic trials of skin and possibly other cancers...
  15. ncbi Profile of gene expression induced by the tumour promotor TPA in murine epithelial cells
    Joerg Schlingemann
    Division of Molecular Genetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Int J Cancer 104:699-708. 2003
    ....
  16. ncbi Differential effects of histone deacetylase inhibitors on phorbol ester- and TGF-beta1 induced murine tissue inhibitor of metalloproteinases-1 gene expression
    David A Young
    School of Biological Sciences, University of East Anglia, Norwich, UK
    FEBS J 272:1912-26. 2005
    ....
  17. ncbi p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase
    Yunfeng Zhao
    Graduate Center for Toxicology, University of Kentucky, Lexington, Kentucky 40536, USA
    Cancer Res 65:3745-50. 2005
    ..Thus, p53 translocation to mitochondria and subsequent inactivation of MnSOD explains the observed mitochondrial dysfunction, which leads to transcription-dependent mechanisms of p53-induced apoptosis...
  18. ncbi Naturally appearing N-feruloylserotonin isomers suppress oxidative burst of human neutrophils at the protein kinase C level
    Rado Nosal
    Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Dubravska 9, 841 04 Bratislava, Slovak Republic
    Pharmacol Rep 63:790-8. 2011
    ..It should be further investigated for its pharmacological activity against oxidative stress in ischemia-reperfusion, inflammation and other pathological conditions...
  19. ncbi SAG/ROC2/Rbx2 is a novel activator protein-1 target that promotes c-Jun degradation and inhibits 12-O-tetradecanoylphorbol-13-acetate-induced neoplastic transformation
    Qingyang Gu
    Department of Radiation Oncology, University of Michigan Comprehensive Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Cancer Res 67:3616-25. 2007
    ..41 preneoplastic model. Thus, AP-1/SAG establishes an autofeedback loop, in which on induction by AP-1, SAG promotes c-Jun ubiquitination and degradation, thus inhibiting tumor-promoting activity of AP-1...
  20. ncbi Essential role of tumor necrosis factor alpha (TNF-alpha) in tumor promotion as revealed by TNF-alpha-deficient mice
    M Suganuma
    Saitama Cancer Center Research Institute, Japan
    Cancer Res 59:4516-8. 1999
    ..All of our results demonstrate that TNF-alpha is the key cytokine for tumor promotion in mouse skin and, very possibly, for carcinogenesis in humans as well...
  21. ncbi SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol
    G Boily
    Center for Cancer Therapeutics, Ottawa Health Research Institute, and Department of Medicine, University of Ottawa, Ontario, Canada
    Oncogene 28:2882-93. 2009
    ..Thus, our results suggest that SirT1 does not behave like a classical tumor-suppressor gene but the antitumor activity of resveratrol is mediated at least in part by SirT1...
  22. ncbi 12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCalpha/ERK/NF-kappaB-dependent MMP-9 expression
    Cheng Wei Lin
    Graduate Institute of Pharmacy, School of Pharmacy, Taipei Medical University, Taipei, Taiwan
    J Cell Physiol 225:472-81. 2010
    ..Application of flavonoids to prevent the migration/invasion of glioblastoma cells through blocking PKCalpha/ERK/NF-kappaB activation is first demonstrated herein...
  23. ncbi TACE/ADAM-17 enzymatic activity is increased in response to cellular stimulation
    John R Doedens
    Department of Cell Biology, Amgen Inc, 51 University St, Seattle, WA 98101, USA
    Biochem Biophys Res Commun 308:331-8. 2003
    ..Based on these observations, induction of TACE-mediated shedding events occurs at least in part via an increase in the enzymatic activity of cellular TACE, independent of its cytoplasmic domain...
  24. ncbi Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells
    Olga V Leontieva
    Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    J Biol Chem 279:5788-801. 2004
    ..Our findings highlight subcellular distribution and phosphorylation state as critical determinants of PKCalpha desensitization pathways...
  25. pmc Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an Src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation
    M M Kessels
    Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720 3202, USA
    Mol Biol Cell 11:393-412. 2000
    ..mAbp1 is a newly identified cytoskeletal protein in mice and may serve as a signal-responsive link between the dynamic cortical actin cytoskeleton and regions of membrane dynamics...
  26. ncbi Epidermal growth factor receptor-stimulated intestinal epithelial cell migration requires phospholipase C activity
    D B Polk
    Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2576, USA
    Gastroenterology 114:493-502. 1998
    ..The aim of this study was to investigate signaling mechanisms of epidermal growth factor (EGF) receptor-stimulated monolayer restitution in a mouse intestinal epithelial cell line...
  27. ncbi Recurrent chemical reactivations of EBV promotes genome instability and enhances tumor progression of nasopharyngeal carcinoma cells
    Chih Yeu Fang
    National Institute of Cancer Research, National Health Research Institutes, Zhunan, Taiwan
    Int J Cancer 124:2016-25. 2009
    ..These results suggest that recurrent EBV reactivations may result in accumulation of genome instability and promote the tumor progression of NPC...
  28. ncbi Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells
    D F Liao
    Department of Medicine, Division of Cardiology, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 272:6146-50. 1997
    ..These results demonstrate an important difference in signal transduction by angII compared with PDGF and phorbol ester in VSMC, and suggest a critical role for PKC-zeta and Ras in angII stimulation of ERK1/2...
  29. ncbi Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
    A O Aliprantis
    Skirball Institute and Department of Microbiology, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Science 285:736-9. 1999
    ..Thus, hTLR2 is a molecular link between microbial products, apoptosis, and host defense mechanisms...
  30. ncbi PMA induces the MUC5AC respiratory mucin in human bronchial epithelial cells, via PKC, EGF/TGF-alpha, Ras/Raf, MEK, ERK and Sp1-dependent mechanisms
    Christopher A Hewson
    Department of Respiratory Medicine, National Heart and Lung Institute, Imperial College London, Norfolk Place, London W2 1PG, UK
    J Mol Biol 344:683-95. 2004
    ..We have characterised a signalling pathway regulating PMA induction of MUC5AC. Studies such as this identify key signalling intermediates as targets for pharmacological intervention to treat mucus hypersecretion...
  31. pmc Cell-type-specific regulation of the two foamy virus promoters
    C D Meiering
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave, Seattle, Washington 98109, USA
    J Virol 75:6547-57. 2001
    ..Our data indicate that differential regulation of transcription is important in the outcome of FV infection but is unlikely to depend on AP-1...
  32. ncbi A highly sensitive fluorescent micro-assay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative
    J G Mohanty
    MCP Hahnemann School of Medicine, Division of Pulmonary and Critical Care Medicine, Allegheny University of the Health Sciences, Philadelphia, PA 19102, USA
    J Immunol Methods 202:133-41. 1997
    ..The protocol described in this study using A6550 to measure H2O2 release from activated granulocytes can be easily adapted to other cell types which generate H2O2...
  33. pmc MSKs are required for the transcription of the nuclear orphan receptors Nur77, Nurr1 and Nor1 downstream of MAPK signalling
    Joanne Darragh
    MRC Protein Phosphorylation Unit, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, Scotland, UK
    Biochem J 390:749-59. 2005
    ..Downstream of anisomycin signalling, a second ERK-dependent pathway, independent of MSK and CREB, was also required for the transcription of Nurr1 and Nor1...
  34. pmc Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis
    Karin Muller-Decker
    Research Program Tumor Cell Regulation, Deutsches Krebsforschungszentrum, and Department of Pathology, Ruprecht Karls University, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:12483-8. 2002
    ..e., dramatically sensitizes the tissue for genotoxic carcinogens...
  35. ncbi Resveratrol modulates phorbol ester-induced pro-inflammatory signal transduction pathways in mouse skin in vivo: NF-kappaB and AP-1 as prime targets
    Joydeb Kumar Kundu
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Shinlim 9 dong, Kwanak gu, Seoul 151 742, South Korea
    Biochem Pharmacol 72:1506-15. 2006
    ....
  36. ncbi IFNgamma promotes papilloma development by up-regulating Th17-associated inflammation
    Mingjie Xiao
    National Laboratory of Biomacromolecules, Chinese Academy of Sciences University of Tokyo Joint Laboratory of Structural Virology and Immunology
    Cancer Res 69:2010-7. 2009
    ..These results show that IFNgamma, under certain conditions, may promote tumor development by enhancing a Th17-associated inflammatory reaction...
  37. ncbi Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
    Montserrat Barragan
    Unitat de Bioquimica, Departament de Ciències Fisioliques II, Universitat de Barcelona, Spain
    Blood 99:2969-76. 2002
    ..These results demonstrate that PKC and PI3-kinase are involved in the survival of B-CLL cells and suggest that inhibitors of these pathways could be combined with the drugs used in the treatment of B-CLL...
  38. ncbi JWA as a functional molecule to regulate cancer cells migration via MAPK cascades and F-actin cytoskeleton
    Hairong Chen
    Department of Molecular Cell Biology and Toxicology, School of Public Health, Nanjing Medical University, 140 Hanzhong Road, Nanjing 210029, People s Republic of China
    Cell Signal 19:1315-27. 2007
    ..Therefore, JWA regulated-tumor cellular migration might involve MAPK cascades activation and F-actin cytoskeleton rearrangement mechanisms. Our data provide an unexpected role for JWA in tumor cell migration behaviors...
  39. ncbi Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis
    Carmen Segrelles
    Molecular Oncology Unit, Division of Biomedicine, Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Madrid, Spain
    Cancer Res 67:10879-88. 2007
    ..Collectively, the data provide direct support for an important role for Akt signaling in epithelial carcinogenesis in vivo, especially during the tumor promotion stage...
  40. ncbi Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    Qing Bai She
    The Hormel Institute, University of Minnesota, Austin, Minnesota 55912, USA
    Cancer Res 62:1343-8. 2002
    ..These results suggest that JNK1 is a crucial suppressor of skin tumor development...
  41. ncbi Suppression of oxidative burst in human neutrophils with the naturally occurring serotonin derivative isomer from Leuzea carthamoides
    Radomir Nosal
    Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovakia
    Neuro Endocrinol Lett 31:69-72. 2010
    ....
  42. ncbi Salix caprea inhibits skin carcinogenesis in murine skin: inhibition of oxidative stress, ornithine decarboxylase activity and DNA synthesis
    Sarwat Sultana
    Department of Medical Elementology and Toxicology, Section of Chemoprevention and Nutrition Toxicology, Faculty of Science, Hamdard University, Hamdard Nagar, New Delhi 110 062, India
    J Ethnopharmacol 91:267-76. 2004
    ..It was concluded from the results that Salix caprea is an effective antioxidant and chemopreventive agent against phorbol ester-induced tumor promotion...
  43. pmc Phosphorylation of adducin by Rho-kinase plays a crucial role in cell motility
    Y Fukata
    Division of Signal Transduction, Nara Institute of Science and Technology, Ikoma 630 0101, Japan
    J Cell Biol 145:347-61. 1999
    ....
  44. ncbi Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition
    Viera Jancinova
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava, Slovakia
    Eur J Pharmacol 612:161-6. 2009
    ..As neutrophils are considered to be cells with the greatest capacity to inflict damage within diseased joints, the observed effects could represent a further mechanism involved in the antirheumatic activity of diferuloylmethane...
  45. ncbi Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate
    Louise L Lilleholt
    Department of Dermatology, Aarhus University Hospital, Denmark
    Acta Derm Venereol 91:271-8. 2011
    ..Although the p38α isoform is important, our data also demonstrate an important role of the p38β and/or δ isoforms in the regulation of TPA-induced skin inflammation...
  46. ncbi Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by TPA and ATRA in gastric cancer cells
    Qiao Wu
    Key Laboratory of the Ministry of Education for Cell Biology, and Tumor Cell Engineering, School of Life Sciences, Xiamen University, Xiamen 361005, Fujian Province, China
    Carcinogenesis 23:1583-92. 2002
    ..Taken together, the data revealed the dual functioning mechanisms of Nur77 in gastric cancer cells in response to TPA and ATRA...
  47. pmc Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: involvement of Meltrin alpha in adipogenesis and myogenesis
    Tomohiro Kurisaki
    Field of Growth Regulation, Institute for Frontier Medical Sciences, Kyoto University, Japan
    Mol Cell Biol 23:55-61. 2003
    ..We also report here the chromosomal locations of Meltrin alpha in the mouse and rat...
  48. pmc GnRH induces the c-Fos gene via phosphorylation of SRF by the calcium/calmodulin kinase II pathway
    Heather A Ely
    Department of Reproductive Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0674, USA
    Mol Endocrinol 25:669-80. 2011
    ..Thus, GnRH uses a combination of growth factor signaling and the CamKII pathway to induce c-Fos to regulate FSHβ gene expression in gonadotrope cells...
  49. pmc Homeobox gene Dlx-2 is implicated in metabolic stress-induced necrosis
    Su Yeon Lee
    Department of Molecular Biology, College of Natural Sciences, Pusan National University, Pusan 609 735, Korea
    Mol Cancer 10:113. 2011
    ..Thus, necrosis has important clinical implications in tumor development; however, its molecular mechanism remains poorly understood...
  50. ncbi Resveratrol inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting JNK and PKC delta signal transduction
    Ju Hyung Woo
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, South Korea
    Oncogene 23:1845-53. 2004
    ..Therefore, we conclude that the MMP-9 inhibition activity of resveratrol and its inhibition of JNK and PKC-delta may have a therapeutic potential, given that a novel means of controlling growth and invasiveness of tumors...
  51. ncbi Isoflavone genistein inhibits the initiation and promotion of two-stage skin carcinogenesis in mice
    H Wei
    Department of Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Carcinogenesis 19:1509-14. 1998
    ..05). Our results suggest that genistein exerts its anti-initiational and anti-promotional effects on skin carcinogenesis probably through blockage of DNA adduct formation and inhibition of oxidative and inflammatory events in vivo...
  52. ncbi Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells
    Ya Fan Liao
    Institute of Biochemical Sciences and Technology, Chaoyang University of Technology, Taichung 41349, Taiwan, ROC
    Food Chem Toxicol 50:2930-6. 2012
    ..Taken together, our data indicate that A. indica can be considered as a source of new anti-metastatic agent for food and pharmaceutical industries...
  53. ncbi Inhibition of phospholipase A(2) abrogates intracellular processing of NADPH-oxidase derived reactive oxygen species in human neutrophils
    Halla Björnsdottir
    The Phagocyte Research Laboratory, Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, University of Gothenburg, Gothenburg 41346, Sweden
    Exp Cell Res 319:761-74. 2013
    ..Instead, we suggest that these PLA(2) inhibitors block heterotypic granule fusion and prohibit the colocalization of ROS and MPO needed for intracellular CL activity...
  54. pmc Stage-specific disruption of Stat3 demonstrates a direct requirement during both the initiation and promotion stages of mouse skin tumorigenesis
    Ken Kataoka
    Department of Carcinogenesis, Science Park Research Division, The University of Texas MD Anderson Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA
    Carcinogenesis 29:1108-14. 2008
    ..Collectively, these results directly demonstrate that Stat3 is required for skin tumor development during both the initiation and promotion stages of skin carcinogenesis in vivo...
  55. ncbi PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways
    Denggao Yao
    Section of Squamous Cell Biology and Dermatology, Division of Cancer Sciences and Molecular Pathology, Glasgow University, Glasgow G11 6NU, Scotland, UK
    Cancer Res 66:1302-12. 2006
    ....
  56. ncbi JAM-1 is a ligand of the beta(2) integrin LFA-1 involved in transendothelial migration of leukocytes
    Georg Ostermann
    Institute for Prevention of Cardiovascular Diseases, Ludwig Maximilians University, Munich, Germany
    Nat Immunol 3:151-8. 2002
    ..Thus, JAM-1 is a counter-receptor for LFA-1 that is ideally situated to guide and control transmigration during leukocyte recruitment...
  57. ncbi Inhibitory effect of magnolol on TPA-induced skin inflammation and tumor promotion in mice
    Daih Huang Kuo
    Department of Pharmacy and Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung, Taiwan
    J Agric Food Chem 58:5777-83. 2010
    ....
  58. ncbi Overexpression of amyloid precursor protein reduces epsilon protein kinase C levels
    T Liron
    Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Tel Aviv University, 69978 Tel Aviv, Israel
    Neuroscience 146:152-9. 2007
    ..Taken together, our results suggest that APP expression levels may play a role in the decrease of epsilon PKC levels in AD brains and could thus affect the responsiveness of AD brain tissues to growth factors and neurotransmitters...
  59. ncbi Calgranulins S100A8 and S100A9 are negatively regulated by glucocorticoids in a c-Fos-dependent manner and overexpressed throughout skin carcinogenesis
    Christoffer Gebhardt
    Deutsches Krebsforschungszentrum, Division of Signal Transduction and Growth Control, 69120 Heidelberg, Germany
    Oncogene 21:4266-76. 2002
    ..These data identify S100A8 and S100A9 as novel, tumor-associated genes and may point to an as yet unrecognized function of both genes in the development of epithelial skin tumors...
  60. ncbi Diallyl trisulfide inhibits phorbol ester-induced tumor promotion, activation of AP-1, and expression of COX-2 in mouse skin by blocking JNK and Akt signaling
    Sangeeta Shrotriya
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Seoul, South Korea
    Cancer Res 70:1932-40. 2010
    ..Taken together, the inhibitory effects of DATS on TPA-induced AP-1 activation and COX-2 expression through modulation of JNK or Akt signaling may partly account for its antitumor-promoting effect on mouse skin carcinogenesis...
  61. pmc PKC alpha affects cell cycle progression and proliferation in human RPE cells through the downregulation of p27kip1
    Qianying Gao
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Mol Vis 15:2683-95. 2009
    ..In this study, we investigated which of these isozymes could be responsible for the cell cycle and proliferation in human RPE cells...
  62. pmc Continuous delta-opioid receptor activation reduces neuronal voltage-gated sodium channel (NaV1.7) levels through activation of protein kinase C in painful diabetic neuropathy
    Munmun Chattopadhyay
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 0316, USA
    J Neurosci 28:6652-8. 2008
    ..7 in DRG through inhibition of PKC and p38. These results establish a novel interaction between the delta-opioid receptor and voltage-gated sodium channels...
  63. ncbi N-methyl-N'-nitro-N-nitrosoguanidine induces and cooperates with 12-O-tetradecanoylphorbol-1,3-acetate/sodium butyrate to enhance Epstein-Barr virus reactivation and genome instability in nasopharyngeal carcinoma cells
    Sheng Yen Huang
    National Tsing Hua University, Hsinchu, Taiwan
    Chem Biol Interact 188:623-34. 2010
    ..Our findings offer a possible mechanism by which N-nitroso compounds induce reactivation of EBV and contribute to malignant progression by enhancing genome instability in NPC cells...
  64. ncbi Attenuation of the oxidative burst-induced DNA damage in human leukocytes by hyaluronan
    H Dorota Halicka
    Brander Cancer Research Institute and Department of Pathology, New York Medical College, Valhalla, NY, 10595, USA
    Int J Mol Med 23:695-9. 2009
    ..The anti-oxidant effect of HA seen during oxidative burst also explains its anti-inflammatory effect when used to treat arthritic joints...
  65. ncbi The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate
    Yi Ling Yang
    Institute of Biotechnology, National Chia Yi University, Chiayi, Taiwan
    J Biomed Sci 15:499-507. 2008
    ..PMA upregulated the expression of iNOS mRNA. Our results suggest that neutrophil activation by PMA causes release of NE, upregulation of iNOS and a series of inflammatory responses leading to endothelial damage and ALI...
  66. pmc RAGE signaling sustains inflammation and promotes tumor development
    Christoffer Gebhardt
    Division of Signal Transduction and Growth Control, German Cancer Research Center, 69120 Heidelberg, Germany
    J Exp Med 205:275-85. 2008
    ..We show that RAGE signaling drives the strength and maintenance of an inflammatory reaction during tumor promotion and provide direct genetic evidence for a novel role for RAGE in linking chronic inflammation and cancer...
  67. pmc Protein kinase C delta regulates airway mucin secretion via phosphorylation of MARCKS protein
    Jin Ah Park
    Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough St, Raleigh, NC 27606, USA
    Am J Pathol 171:1822-30. 2007
    ..The results suggest that PKC delta plays an important role in mucin secretion by airway epithelium via regulation of MARCKS phosphorylation...
  68. pmc Extracellular signal-regulated kinase phosphorylates tumor necrosis factor alpha-converting enzyme at threonine 735: a potential role in regulated shedding
    Elena Diaz-Rodriguez
    Instituto de Microbiología Bioquímica and Centro de Investigación del Cáncer, Consejo Superior de Investigaciones Cientificas Universidad de Salamanca, 37007 Salamanca, Spain
    Mol Biol Cell 13:2031-44. 2002
    ....
  69. ncbi Differentiation-associated genes regulated by TPA-induced c-Jun expression via a PKC/JNK pathway in KYSE450 cells
    Xinfeng Yu
    National Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, PR China
    Biochem Biophys Res Commun 342:286-92. 2006
    ..Taken together, these results suggested that differentiation-associated genes were regulated by TPA-induced c-Jun/AP-1 mainly via a PKC/JNK pathway in esophageal cancer cell line KYSE450...
  70. ncbi Xanthorrhizol inhibits 12-O-tetradecanoylphorbol-13-acetate-induced acute inflammation and two-stage mouse skin carcinogenesis by blocking the expression of ornithine decarboxylase, cyclooxygenase-2 and inducible nitric oxide synthase through mitogen-acti
    Won Yoon Chung
    Department of Oral Biology, Yonsei University, College of Dentistry, Seodaemoon Gu, Seoul, Korea
    Carcinogenesis 28:1224-31. 2007
    ....
  71. ncbi Protein kinase C-ERK1/2 signal pathway switches glucose depletion-induced necrosis to apoptosis by regulating superoxide dismutases and suppressing reactive oxygen species production in A549 lung cancer cells
    Cho Hee Kim
    Department of Molecular Biology, College of Natural Sciences, and Research Institute of Genetic Engineering, Pusan National University, Pusan, Korea
    J Cell Physiol 211:371-85. 2007
    ....
  72. ncbi Expression of adipose differentiation-related protein (ADRP) is conjointly regulated by PU.1 and AP-1 in macrophages
    Ping Wei
    Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Biochem 138:399-412. 2005
    ..1/AP-1 complex formation on EMSA. From these results, we concluded that the Ets/AP-1 site is an important cis-acting element that regulates the ADRP gene expression in macrophages...
  73. ncbi A mechanism-based antioxidant approach for the reduction of skin carcinogenesis
    Yunfeng Zhao
    Graduate Center for Toxicology and Department of Radiation Medicine, University of Kentucky, Lexington, Kentucky, USA
    Cancer Res 65:1401-5. 2005
    ..Remarkably, the incidence and multiplicity of skin tumors were reduced in mice that received MnTE-2-PyP(5+) before cell proliferation. These results show a novel strategy for an antioxidant approach to cancer intervention...
  74. ncbi Resveratrol inhibits phorbol ester-induced cyclooxygenase-2 expression in mouse skin: MAPKs and AP-1 as potential molecular targets
    Joydeb Kumar Kundu
    College of Pharmacy, Seoul National University, Seoul 151 742, South Korea
    Biofactors 21:33-9. 2004
    ....
  75. pmc The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors
    Robert J B Nibbs
    Division of Immunology, Infection and Inflammation, Glasgow Biomedical Research Centre, University of Glasgow, Glasgow, UK
    J Clin Invest 117:1884-92. 2007
    ..These data demonstrate the importance of proinflammatory CC chemokines in de novo tumorigenesis and reveal chemokine sequestration by D6 to be a novel and effective method of tumor suppression...
  76. ncbi Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 226:30-7. 2008
    ....
  77. ncbi Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis
    Govind J Kapadia
    Laboratory of Natural Drug Products, Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, 2300 4th Street NW, Washington, DC 20059, USA
    Pharmacol Res 45:499-505. 2002
    ..The observed chemopreventive effect of these products particularly warrants more attention since they already exist in the population with no known adverse effects...
  78. ncbi FGF-2 and TPA induce matrix metalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway
    Jian Feng Liu
    Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires, CNRS UPRES A 7053, Universite Paris XII, avenue du General de Gaulle, 94000 Creteil, France
    Biochem Biophys Res Commun 293:1174-82. 2002
    ..These results demonstrated that FGF-2 and TPA induce MMP-9 secretion in MCF-7 cells mainly through PKC-dependent activation of the Ras/ERK(1/2) signaling pathway...
  79. ncbi Phorbol myristate acetate induces neutrophil NADPH-oxidase activity by two separate signal transduction pathways: dependent or independent of phosphatidylinositol 3-kinase
    A Karlsson
    Department of Medical Microbiology and Immunology, University of Goteborg, Sweden
    J Leukoc Biol 67:396-404. 2000
    ..As the two oxidase responses were differently affected by the inhibitor Gö-6850, different PKC isozymes are suggested to take part in the two signal transduction pathways...
  80. ncbi Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromog
    Raktima Raychowdhury
    Medizinische Klink mit Schwerpunkt Gastroenterologie, Hepatologie, Endokrinologie und Stoffwechsel, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, 13353 Berlin, Germany
    Mol Endocrinol 16:2802-18. 2002
    ..Our studies for the first time identify Egr-1 as a nuclear target of gastrin and show that functional interplay of Egr-1, Sp1, and CREB is indispensable for gastrin-dependent CgA transactivation in gastric epithelial cells...
  81. ncbi Protein kinase C modulates NMDA receptor trafficking and gating
    J Y Lan
    Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nat Neurosci 4:382-90. 2001
    ..Thus, PKC regulates NMDAR channel gating and trafficking in recombinant systems and in neurons, mechanisms that may be relevant to synaptic plasticity...
  82. ncbi Activation of protein kinase Calpha inhibits growth of pancreatic cancer cells via p21(cip)-mediated G(1) arrest
    K M Detjen
    Medizinische Klinik mit Schwerpunkt Hepatologie und Gastroenterologie, Universitatsklinikum Charite, Campus Virchow Klinikum, Augustenburger Platz 1, Germany
    J Cell Sci 113:3025-35. 2000
    ....
  83. ncbi Molecular cloning, sequence, and expression of a cDNA encoding the chicken myristoylated alanine-rich C kinase substrate (MARCKS)
    J M Graff
    Howard Hughes Medical Institute Laboratories, Durham, North Carolina 27710
    Mol Endocrinol 3:1903-6. 1989
    ..These conserved regions are likely to represent domains of some functional importance for this widely distributed cellular substrate for PKC...
  84. ncbi Protective effect of lipophilic antioxidants on phorbol-induced acute lung injury in rats
    S J Chu
    Department of Emergency Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Crit Care Med 29:819-24. 2001
    ....
  85. pmc Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion
    Satish B Cheepala
    Department of Biochemistry, Louisiana State University Health Sciences Center Shreveport and Feist Weiller Cancer Center, Shreveport, Louisiana 17730, USA
    Mol Cancer 8:27. 2009
    ..In this study we have attempted to understand the chemopreventive mechanism of all-trans retinoic acid (ATRA), a primary biologically active retinoid, in order to more efficiently utilize retinoids in the clinic...
  86. ncbi Inhibition of HuR and MMP-9 expression in macrophage-differentiated HL-60 myeloid leukemia cells by green tea polyphenol EGCg
    Borhane Annabi
    Laboratoire d Oncologie Moleculaire, Departement de Chimie, Centre BIOMED, Universite du Quebec a Montreal, Montreal, Quebec, Canada
    Leuk Res 31:1277-84. 2007
    ..Specific catechins may help optimize current chemotherapeutic treatment protocols for leukemia...
  87. ncbi Stromal cell-derived factor-1-induced LFA-1 activation during in vivo migration of T cell hybridoma cells requires Gq/11, RhoA, and myosin, as well as Gi and Cdc42
    R D Soede
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Immunol 166:4293-301. 2001
    ..We conclude that two modes of LFA-1 activation, with distinct underlying mechanisms, are required for the in vivo migration of T cell hybridomas...
  88. pmc GABP factors bind to a distal interleukin 2 (IL-2) enhancer and contribute to c-Raf-mediated increase in IL-2 induction
    A Avots
    Department of Molecular Pathology, Institute of Pathology, University of Wurzburg, Germany
    Mol Cell Biol 17:4381-9. 1997
    ..Flory, A. Hoffmeyer, U. Smola, U. R. Rapp, and J. T. Bruder, J. Virol. 70:2260-2268, 1996), these results indicate a contribution of GABP factors to the Raf-mediated enhancement of IL-2 induction during T-cell activation...
  89. ncbi Protein kinase C alpha activates RAF-1 by direct phosphorylation
    W Kolch
    Biological Research, Goedecke AG, Freiburg, Germany
    Nature 364:249-52. 1993
    ..Consistent with such a direct interaction is the observation that Raf-1 and PKC alpha cooperate in the transformation of NIH3T3 cells. The Ser499 phosphorylation site is necessary for this synergism...
  90. ncbi Silibinin prevents TPA-induced MMP-9 expression and VEGF secretion by inactivation of the Raf/MEK/ERK pathway in MCF-7 human breast cancer cells
    Sangmin Kim
    Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon Dong, Kangnam Gu, Seoul 135 710, South Korea
    Phytomedicine 16:573-80. 2009
    ..Taken together, we suggest that the inhibition of TPA-induced MMP-9 and VEGF expression by silibinin is mediated by the suppression of the Raf/MEK/ERK pathway in MCF-7 breast cancer cells...
  91. pmc Protein kinase C phosphorylation sensitizes but does not activate the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1)
    Gautam Bhave
    Division of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 100:12480-5. 2003
    ..Furthermore, modulation of the TRPV1 function by PKC appears to involve distinct phosphorylation sites depending on the mechanism of channel activation...
  92. ncbi Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Life Sci 82:348-58. 2008
    ....
  93. pmc Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
    J Taunton
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Cell Biol 148:519-30. 2000
    ..Conversely, by nucleating actin assembly, intracellular membranes may contribute to the dynamic organization of the actin cytoskeleton...
  94. ncbi Interaction of protein kinase C isozymes with Rho GTPases
    S J Slater
    Department of Pathology, Cell Biology and Anatomy, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Biochemistry 40:4437-45. 2001
    ..Such an interaction could result in significant cross-talk between the distinct pathways regulated by these two signaling elements...
  95. pmc The thyroid hormone receptors as modulators of skin proliferation and inflammation
    Constanza Contreras-Jurado
    Instituto de Investigaciones Biomédicas de Madrid, Consejo Superior de Investigaciones Cientificas, and Universidad Autónoma de Madrid, 28029 Madrid, Spain
    J Biol Chem 286:24079-88. 2011
    ....
  96. pmc The pH dependence of NADPH oxidase in human eosinophils
    Deri Morgan
    Department of Molecular Biophysics and Physiology, Rush University Medical Center, 1750 West Harrison, Chicago, IL 60612, USA
    J Physiol 569:419-31. 2005
    ....
  97. pmc Regulation of c-Rel nuclear localization by binding of Ca2+/calmodulin
    Asa Antonsson
    Department of Molecular Biology, Umea University, 901 87 Umea, Sweden
    Mol Cell Biol 23:1418-27. 2003
    ..CaM can therefore differentially regulate the activation of NF-kappa B/Rel proteins following stimulation...
  98. ncbi Dominant-negative activator protein 1 (TAM67) targets cyclooxygenase-2 and osteopontin under conditions in which it specifically inhibits tumorigenesis
    Connie P Matthews
    Laboratory of Cancer Prevention, National Cancer Institute, Frederick, Maryland 21702, USA
    Cancer Res 67:2430-8. 2007
    ..Results identify both Cox-2 and Opn as transcriptional targets of TAM67 with CRE, but not NFkappaB sites important in the Cox-2 promoter and an AP-1 site important in the Opn promoter...
  99. ncbi Immune complex-induced integrin activation and L-plastin phosphorylation require protein kinase A
    J Wang
    Division of Infectious Diseases and Program in Molecular Cell Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:24349-56. 1999
    ..These data demonstrate a necessary role for PKA in IC-induced integrin activation and LPL phosphorylation...
  100. pmc The nucleosomal response associated with immediate-early gene induction is mediated via alternative MAP kinase cascades: MSK1 as a potential histone H3/HMG-14 kinase
    S Thomson
    Nuclear Signalling Laboratory, The Randall Institute, King s College, London, WC2B 5RL, UK
    EMBO J 18:4779-93. 1999
    ..Thus, the nucleosomal response is an invariable consequence of ERK and p38 but not JNK/SAPK activation, and MSK1 potentially provides a link to complete the circuit between cell surface and nucleosome...
  101. ncbi Characterization of the promoter region of the human PARG gene and its response to PU.1 during differentiation of HL-60 cells
    Fumiaki Uchiumi
    Department of Gene Regulation, Faculty of Pharmaceutical Sciences, Tokyo University of Scie, Noda, Chiba, Japan
    Genes Cells 13:1229-47. 2008
    ..1 expression plasmid and pPARG-Luc indicated that PU.1 down-regulate the PARG promoter. These results suggest that PARG gene expression is modulated by PU.1 during TPA-induced differentiation of HL-60 cells...

Research Grants65

  1. PHOSPHORYLATION OF THE GLUCOSE TRANSPORTER BY INSULIN
    David Sacks; Fiscal Year: 1991
    ..g., phospholipase C, diacylglycerol, the phorbol ester tetradecanoylphorbol acetate) and inhibitors (e.g...
  2. NITRIC OXIDE AND TUMOR PROMOTION
    Fredika Robertson; Fiscal Year: 2000
    ..indicates that both reactive nitrogen and oxygen species are formed in skin treated with tumor promoter tetradecanoylphorbol acetate (TPA) in a multistage carcinogenesis (DMBA/TPA) model and in skin treated chronically with the complete ..
  3. REGULATION OF PGHS-2 SYNTHESIS--ROLE OF LIPID MEDIATORS
    LARRY DANIEL; Fiscal Year: 2000
    ..In addition, new targets for therapeutic intervention should become apparent that can be used to develop treatment strategies that are more selective and have less adverse effects than those currently available. ..
  4. HPV DIFFERENTIATION DEPENDENT REPLICATION
    Craig Meyers; Fiscal Year: 1999
    ....
  5. Ceramide synthase as a therapy target in prostate cancer
    Adriana Haimovitz Friedman; Fiscal Year: 2009
    ..abstract_text> ..
  6. Chemopreventive effects of sarcodiol on skin cancer
    Hesham Fahmy; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The proposed project deals with skin cancer prevention, one of the most common cancers in the US. Sarcodiol has a very good potential to prevent UVB-induced skin cancer. ..
  7. PHOSPHOINOSITIDE HYDROLYSIS AND BETA CELL SECRETION
    Walter Zawalich; Fiscal Year: 2006
    ..These aims will be accomplished by using sound principles of experimentation and employing isolated islets that retain their in vivo sensitivity to glucose. ..
  8. Regulation of Lung Epithelial Fibrinolysis by Urokinase
    Sreerama Shetty; Fiscal Year: 2005
    ..This information could hasten the development of new, mechanism-based interventions for lung disorders, including acute lung injury or lung neoplasia. ..
  9. Identification of a new protein that binds Src and PKC
    STEPHEN SOLTOFF; Fiscal Year: 2004
    ..Future efforts will determine if this new protein alters cell morphology, tight junction formation, or other functions in salivary cells. ..
  10. CONTROL OF FIBRINOLYTIC PATHWAYS IN LUNG DISEASE
    Sreerama Shetty; Fiscal Year: 2004
    ..abstract_text> ..
  11. Role of Osteopontin in Tumor Promotion
    Pi Ling Chang; Fiscal Year: 2005
    ..Together, these studies will provide a better understanding of the role of OPN in tumor promotion and may contribute to the design of a mechanism-based strategy for cancer prevention. ..
  12. The function of RhoBTB proteins
    STEPHEN PAUL SOLTOFF; Fiscal Year: 2010
    ..The results of these studies may reveal a new pathway involved in the development of cancer and advance our understanding of the basic biology of transformation. ..
  13. Protein Kinase C Modulation of NMDAR Ethanol Sensitivity
    ROSEANNA POPP; Fiscal Year: 2006
    ..Thus, facilitating the future design of novel therapeutic strategies to be used in the treatment of alcoholism and alcohol abuse...
  14. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2010
    ..The intensity and the extent of staining will be semi-quantified for calculating a composite score, which will be correlated with clinico-pathological progression of PCa, including HR PCa. ..
  15. Osteopontin and microenvironment of initiated cells
    Pi Ling Chang; Fiscal Year: 2010
    ..These proposed in vivo and in vitro studies will shed light on the molecular mechanism(s) by which a matricellular protein enhances the survival of transforming cells during early tumor promotion. ..
  16. PKC modulation of calcium current and anesthetic action
    GANESAN KAMATCHI; Fiscal Year: 2007
    ..abstract_text> ..
  17. Regularity Mechanisms of Aldosterone Secretion
    Wendy Bollag; Fiscal Year: 2006
    ..The complex interactions between AngII and serum K+ levels suggest that abnormalities in the glomerulosa cell response to either agonist, or both, may contribute to the development of some forms of hypertension. [unreadable] [unreadable]..
  18. Substrates of SAG-SCF E3 ligase regulate hypoxia response
    Yi Sun; Fiscal Year: 2007
    ..These initial studies will set the stage for a more detailed investigation of the mechanism of SAG mediated suppression of apoptosis. [unreadable] [unreadable]..
  19. REGULATION OF PLATELET SHAPE CHANGES
    John Hartwig; Fiscal Year: 2008
    ..abstract_text> ..
  20. Cellular Signaling Mechanisms in Macrophage Activation.
    Joseph Cuschieri; Fiscal Year: 2007
    ..Through an enhanced understanding of these mechanisms it is our goal that potential therapeutic targets may be discovered to regulate the inflammatory response following trauma/hemorrhage and ischemia/reperfusion. ..
  21. Inhibition of Macrophage Innate Immunity in Tuberculosis
    WILLIAM NAUSEEF; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  22. Oral Infectious Disease: Virulence and Host Determinants
    DAVID CULP; Fiscal Year: 2009
    ..Future studies can then focus on molecular mechanisms of host-pathogen interactions. Results may indicate important therapeutic targets to treat patients at high risk for caries (i.e., patients with xerostomia). ..
  23. Protective Role of Heme Oxygenase in Ischemic Brain
    MAHIN MAINES; Fiscal Year: 2005
    ..Genes will be delivered by CSF or by intracarotid route and the same indeces will be evaluated. ..
  24. GENETIC, BIOLOGIC, & IMMUNOLOGIC DETERMINANTS OF ASTHMA
    Mario Castro; Fiscal Year: 2006
    ..abstract_text> ..
  25. A Renal Epithelial Urea Sensor
    David Cohen; Fiscal Year: 2005
    ..In addition, the sufficiency of these and related signaling elements for urea signaling will be examined in models of heterologous expression. ..
  26. SNARE PROTEINS IN PLATELET ALPHA-GRANULE SECRETION
    Robert Flaumenhaft; Fiscal Year: 2007
    ..abstract_text> ..
  27. SIGNAL TRANSDUCTION IN PMN AND EOSINOPHIL ACTIVATION
    LARRY DANIEL; Fiscal Year: 2001
    ..Therefore, multiple strategies of intervention may be required. Our studies of the interactions among cell types and mediators will provide a foundation for these strategies. ..
  28. MOLECULAR BASIS OF AIRWAY SQUAMOUS CELL DIFFERENTIATION
    SEKHAR POTHIREDDY; Fiscal Year: 2002
    ..This study will help us better understand the plasticity of airway epithelial cell differentiation and the response of airway epithelial cells to environmental insults. ..
  29. Insulin/TZD regulation of protein structure in fat cells
    Fred Schaufele; Fiscal Year: 2004
    ..conformation of C/EBPa, PPARg, RXRa and the same co-activators, and3. conformations, dimers and interactions of the above factors specifically in the neighborhood of the genes that they regulate. ..
  30. MULTIPLE FORMS OF HEME OXYGENASE--REGULATION BY TOXINS
    MAHIN MAINES; Fiscal Year: 2001
    ..The nature of the second HO-2 immunoreactive protein in GC-treated rat testis also will be investigated. ..
  31. Control of Conjuctival Goblet Cell Mucin Production
    Darlene Dartt; Fiscal Year: 2009
    ..Study of the signaling pathways that stimulate conjunctival goblet cell proliferation will lead to the development of treatments to replenish the mucin layer in these diseases. ..
  32. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..New findings from this project will enhance our knowledge of the complexity of biosynthetic mechanisms for endogenous opioid and neuropeptide systems. ..
  33. PKC Signaling in cAMP-Induced Pulmonary Vasodilation
    SCOTT BARMAN; Fiscal Year: 2010
    ..Progress of these studies will provide important knowledge towards the development of novel therapeutic agents that will help reduce the morbidity and mortality associated with pulmonary hypertension. ..
  34. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  35. Transcription indication reporter array technology
    Xin Jiang; Fiscal Year: 2004
    ..The expressed tag sequences can then be determined with an array assay. With this technology, the simultaneous activation of multiple transcription factors in signal transduction pathways in vivo can be monitored at once. ..
  36. Aggressive Periodontitis and Formylpeptide Receptor SNPs
    John Walters; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. Structure and Function of Endothelial Fenestrae
    RADU VIRGIL STAN; Fiscal Year: 2010
    ..The techniques employed are cell isolation, fractionation, biochemical assays, cell free-assays, genetically modified animal models, cell culture, transfections, light and electron microscopy. ..
  38. Mechanisms directing oncoprotein and cytokine mRNA decay
    GERALD WILSON; Fiscal Year: 2008
    ..Together, these studies will further our understanding of the relationships between ARE structure, trans-factor recognition, and the cellular functions of resulting RNP complexes. ..
  39. IL-2 Suppression by Endocannabinoid Activation of PPARgamma
    NORBERT EDWARD KAMINSKI; Fiscal Year: 2010
    ....
  40. TRANSCRIPTION FACTOR INTERACTIONS AT THE GH PROMOTER
    Fred Schaufele; Fiscal Year: 2008
    ..Determine the effects of Pit- l and C/EBPalpha expression on biochemical recruitment of Pit- 1, C/EBPalpha and relevant co-factors specifically at the GH and PRL promoters and at alpha-satellite DNA. ..
  41. Chemical Genetic Analysis of Platelet Granule Secretion
    Robert Flaumenhaft; Fiscal Year: 2008
    ..Once identified, compounds will be tested in a previously established battery of platelet function tests and evaluated for antithrombotic potential in an in vivo murine model of thrombus formation. [unreadable] [unreadable] [unreadable]..
  42. PROTEOMIC ANALYSIS OF AGE-RELATED MACULAR DEGENERATION
    TONGALP TEZEL; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  43. A Novel Technique of Imposing Femtonewton Forces
    Jin Yu Shao; Fiscal Year: 2007
    ..Therefore, the EMAT should have great potential to make an impact in the field of single molecule and single bond biophysics. [unreadable] [unreadable]..
  44. UCSF High Throughput Microscope
    Fred Schaufele; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  45. Cerebral Microvascular Endothelin Production
    Momoh Yakubu; Fiscal Year: 2003
    ..Our understanding of the mechanisms underlying the consequences of SAH will make it possible for early and appropriate intervention to prevent or reduce these complications from hemorrhagic stroke. ..
  46. TECNIA 12 BioTWIN Transmission Electron Microscope
    Guido Zampighi; Fiscal Year: 2003
    ..abstract_text> ..
  47. ETHANOL METABOLISM IN PREGNANCY--ROLE OF DIET
    Martin Ronis; Fiscal Year: 2005
    ....
  48. Expression of TRPV1 and variant TRPV1 in the kidney
    David Cohen; Fiscal Year: 2005
    ..In addition, such a reagent might have potential therapeutic utility with respect to this important pathway mediating nociception. ..
  49. INTEGRATED DNA SEQUENCING SYSTEM
    Vivian Hook; Fiscal Year: 2002
    ..abstract_text> ..
  50. A Method To Study Membrane Protein Structure
    Guido Zampighi; Fiscal Year: 2003
    ....
  51. Uptake of Fluoroquinolones and Tetracyclines by Gingiva
    John Walters; Fiscal Year: 2003
    ..Strategies that optimize the uptake and distribution of antimicrobial agents should enhance the elimination of invasive pathogens from the periodontium and other types of mucosa. ..
  52. Airway Remodeling in Severe Asthma
    Mario Castro; Fiscal Year: 2005
    ..The identification of the potential variables associated with remodeling and severe asthma will help identify individuals at risk who would benefit from specific targeted therapy. ..
  53. A functional array for signature of breast cancer
    Xin Jiang; Fiscal Year: 2005
    ....
  54. Serpin Protease Inhibitors & Opioid Neuropeptides
    Vivian Hook; Fiscal Year: 2006
    ..Serpin regulation of opioid peptides that mediate analgesia and stress may lead to development of new therapeutic approaches in pain and neurologic disease. ..
  55. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  56. Mechanism of Thimerosal Induced Neurotoxicity
    KINSLEY KININGHAM; Fiscal Year: 2003
    ..This project will generate mechanistic data on thimerosal neurotoxicity and potentially identify specific targets for pharmacological intervention. ..
  57. EICOSANOIDS AND NO IN CEREBROVASCULAR THROMBOSIS
    Kenneth Wu; Fiscal Year: 2003
    ..It is intended that this program will enable several laboratories to work individually and together to achieve the highest degree of innovating and productivity. ..
  58. DOES PKU PROTECT AGAINST CANCER?
    Neil Sidell; Fiscal Year: 2003
    ....
  59. PHENYLACETATE--NOVEL THERAPEUTIC USES IN BREAST CANCER
    Neil Sidell; Fiscal Year: 2005
    ..Taken together, the information gained from these studies will provide a basic framework for the rationale use of PA analogs or similar acting compounds in the clinic. ..
  60. Neuregulin-2 and the formation of neuromuscular synapses
    Mendell Rimer; Fiscal Year: 2006
    ..Results from the proposed research are expected to yield new insights into the molecular mechanisms that control neurotransmitter receptor density at the NMJ, which may bear on such control at synapses in the brain. ..
  61. MOLECULAR NEUROBIOLOGY OF DEPRESSION
    Richard Shelton; Fiscal Year: 2003
    ..Develop further expertise in basic molecular biological methods; 2. Develop new projects oriented to future funding opportunities; and 3. Continue to mentor the next generation of investigators. ..
  62. Molecular Characterization of the SLC19A2 Promoter
    JACK REIDLING; Fiscal Year: 2005
    ..Nothing is known about possible regulation of the thiamine uptake process during development and whether this includes promoter regulation. These issues will be addressed in this proposal. ..
  63. Irreversible inhibitors of cholesterol esterase
    LORRAINE DECK; Fiscal Year: 2005
    ....
  64. Signal Transduction in Depression
    Richard Shelton; Fiscal Year: 2008
    ..These studies may shed light on important cellular mediators of depression and provide new targets for amelioration. [unreadable] [unreadable]..