kaurane diterpenes

Summary

Summary: A group of DITERPENES cyclized into four rings.

Top Publications

  1. ncbi Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1187-93. 2003
  2. ncbi Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES
    Linda C Meade-Tollin
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 67:2-4. 2004
  3. pmc Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo
    Guang Biao Zhou
    State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China
    Blood 109:3441-50. 2007
  4. ncbi Anti-proliferation effect of oridonin on HL-60 cells and its mechanism
    Jia Jun Liu
    Laboratory of Forensic and Biological Science, Medical College of Sun Yat sen University, Guangzhou 510080
    Chin Med Sci J 19:134-7. 2004
  5. ncbi The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
    Sophie Chen
    NovaSpes Research Lab, Hawthorne, NY 10532, USA
    Int J Oncol 26:579-88. 2005
  6. ncbi Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action
    Jia Jun Liu
    Department of Hematology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, PR China
    Am J Hematol 81:86-94. 2006
  7. pmc Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages
    B de Las Heras
    Departamento de Farmacología Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 152:249-55. 2007
  8. ncbi Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells
    Dan Li
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, China
    Biol Pharm Bull 30:254-60. 2007
  9. ncbi [Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata]
    Fumihiro Nagashima
    Planta Med 69:377-9. 2003
  10. ncbi Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome
    Chun Ling Zhang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Asian Nat Prod Res 6:127-38. 2004

Research Grants

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009

Detail Information

Publications163 found, 100 shown here

  1. ncbi Oridonin induces growth inhibition and apoptosis of a variety of human cancer cells
    Takayuki Ikezoe
    Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Int J Oncol 23:1187-93. 2003
    ..Oridonin may be a novel, adjunctive therapy for a large variety of malignancies and probably represents one of the major, active components of PC-SPES...
  2. ncbi Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES
    Linda C Meade-Tollin
    Southwest Center for Natural Products Research and Commercialization, Office of Arid Lands Studies, College of Agriculture and Life Sciences, University of Arizona, 250 E Valencia Road, Tucson, AZ 85706 6800, USA
    J Nat Prod 67:2-4. 2004
    ....
  3. pmc Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo
    Guang Biao Zhou
    State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China
    Blood 109:3441-50. 2007
    ..These results suggest that oridonin may be a potential antileukemia agent that targets AE oncoprotein at residue D188 with low adverse effect, and may be helpful for the treatment of patients with t(8;21) AML...
  4. ncbi Anti-proliferation effect of oridonin on HL-60 cells and its mechanism
    Jia Jun Liu
    Laboratory of Forensic and Biological Science, Medical College of Sun Yat sen University, Guangzhou 510080
    Chin Med Sci J 19:134-7. 2004
    ..To investigate the anti-proliferation effect of oridonin on leukemic HL-60 cells and its mechanism...
  5. ncbi The cytostatic and cytotoxic effects of oridonin (Rubescenin), a diterpenoid from Rabdosia rubescens, on tumor cells of different lineage
    Sophie Chen
    NovaSpes Research Lab, Hawthorne, NY 10532, USA
    Int J Oncol 26:579-88. 2005
    ..The present data suggest that further studies are warranted to assess the potential of oridonin in cancer prevention and/or treatment...
  6. ncbi Antiproliferation effects of oridonin on HPB-ALL cells and its mechanisms of action
    Jia Jun Liu
    Department of Hematology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, PR China
    Am J Hematol 81:86-94. 2006
    ..The results indicate that oridonin may serve as a potential antileukemia reagent...
  7. pmc Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages
    B de Las Heras
    Departamento de Farmacología Facultad de Farmacia, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 152:249-55. 2007
    The kaurane diterpenes foliol and linearol are inhibitors of the activation of nuclear factor kappaB, a transcription factor involved in the inflammatory response...
  8. ncbi Oridonin inhibited the tyrosine kinase activity and induced apoptosis in human epidermoid carcinoma A431 cells
    Dan Li
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, China
    Biol Pharm Bull 30:254-60. 2007
    ..The decrease in the tyrosine kinase activity and the blockage of EGFR tyrosine phosphorylation might be one of the causes of oridonin-induced A431 cell death...
  9. ncbi [Apoptosis-inducing properties of ent-kaurene-type diterpenoids from the liverwort Jungermannia truncata]
    Fumihiro Nagashima
    Planta Med 69:377-9. 2003
    ..These data suggest that induction of apoptosis by 1 and some of its related compounds are dependent on caspases activation and might be partly involved in the cytotoxicity in HL-60 cells...
  10. ncbi Oridonin induced A375-S2 cell apoptosis via bax-regulated caspase pathway activation, dependent on the cytochrome c/caspase-9 apoptosome
    Chun Ling Zhang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    J Asian Nat Prod Res 6:127-38. 2004
    ..4 micromol L(-1)) for 12 h, the majority of A375-S2 cells underwent necrosis as measured by an LDH activity-based assay. Our results suggest that oridonin induces A375-S2 cell death on the balance of apoptosis and necrosis...
  11. ncbi Ent-kaurene synthase from the fungus Phaeosphaeria sp. L487. cDNA isolation, characterization, and bacterial expression of a bifunctional diterpene cyclase in fungal gibberellin biosynthesis
    H Kawaide
    Laboratory for Plant Hormone Function, Frontier Research Program, The Institute of Physical and Chemical Research RIKEN, Wako, Saitama 351 01
    J Biol Chem 272:21706-12. 1997
    ..These results indicate that the fungus has a bifunctional diterpene cyclase that can convert geranylgeranyl diphosphate into ent-kaurene. They may be separate catalytic sites for the two cyclization reactions...
  12. ncbi Effects of oridonin on proliferation of HT29 human colon carcinoma cell lines both in vitro and in vivo in mice
    Yu Zhu
    Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China
    Pharmazie 62:439-44. 2007
    ..Inhibition of the solid tumor was observed. As a result, oridonin could inhibit the proliferation of HT29 cells both in vitro and in vivo, and induce apoptosis partly via the mitochondrial pathway...
  13. ncbi Occurrence, biological activities and synthesis of kaurane diterpenes and their glycosides
    Pablo Anselmo García
    Departamento de Quimica Farmaceutica, Facultad de Farmacia, Universidad de Salamanca, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Molecules 12:455-83. 2007
    This paper presents a review on kaurane diterpenes and their glycoside derivatives, covering aspects of their occurrence, biological activities and the synthesis of these natural products and their analogues...
  14. ncbi PTP1B inhibitory activity of kaurane diterpenes isolated from Siegesbeckia glabrescens
    Sohee Kim
    Korea Research Institute of Bioscience and Biotechnology, 52 Eoun dong, Yuseong Gu, Daejeon 305 333 Korea, South Korea
    J Enzyme Inhib Med Chem 21:379-83. 2006
    ..6 +/- 2.1 microM, respectively. Kinetic studies suggest that both 1 and 2 are non-competitive inhibitors of PTP1B. However, compound 3 substituted with a hydroxyl group at C-17 in kaurane-type showed no inhibitory effects towards PTP1B...
  15. ncbi Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo
    Guang Biao Zhou
    State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road II, Shanghai 200025, China
    Cell Res 17:274-6. 2007
  16. ncbi Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK
    A Castrillo
    Instituto de Bioquimica, Centro Mixto Consejo Superior de Investigaciones Cientificas-Universidad Complutense de Madrid, Spain
    J Biol Chem 276:15854-60. 2001
    ..The absence of a coordinate activation of MAPK and IKK might contribute to a deficient activation of NF-kappaB that is involved in the anti-inflammatory activity of these molecules...
  17. ncbi [Oridonin induced U937 cell apoptosis through ERK pathway]
    Yan Qiu Liu
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, China
    Zhongguo Zhong Yao Za Zhi 30:1856-9. 2005
    ..To study the mechanisms of oridonin-induced U937 cell apoptosis, and to examine the role of ERK MAPK...
  18. ncbi Bcl-2 up-regulation and P-p53 down-regulation account for the low sensitivity of murine L929 fibrosarcoma cells to oridonin-induced apoptosis
    Jian Huang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, P R China
    Biol Pharm Bull 28:2068-74. 2005
    ..These results indicated that in L929 cells, there was a relationship among the low sensitivity to oridonin, down-regulation of p53 phosphorylation and Bcl-2 up-regulation...
  19. ncbi Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells
    Kar Lok Wong
    Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, R O C
    Planta Med 70:108-12. 2004
    ..Alteration in the Kv channel also plays a critical role in the inhibitory action of isosteviol...
  20. ncbi Oridonin induces apoptosis of HeLa cells via altering expression of Bcl-2/Bax and activating caspase-3/ICAD pathway
    Chun Ling Zhang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    Acta Pharmacol Sin 25:691-8. 2004
    ..To study the mechanisms by which oridonin inhibited HeLa cell growth in vitro...
  21. ncbi Isolation and purification of oridonin from Rabdosia rubescens using upright counter-current chromatography
    Yanbin Lu
    Department of Chemistry, Zhejiang University, Hangzhou, 310027, China
    J Sep Sci 29:314-8. 2006
    ..8% was obtained from 200 mg of the crude sample in a single-step CCC separation. The structure of oridonin was identified by ESI-MS, 1H NMR, and 13C NMR...
  22. ncbi Authentication and chemical study of isodonis herba and isodonis extracts
    Takuro Maruyama
    Division of Pharmacognosy, Phytochemistry and Narcotics, National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 55:1626-30. 2007
    ..Understanding the relationship between extract constituents and DNA profiles is important for the official specification of dietary supplements and food additives of plant origin...
  23. ncbi Differential control of growth, cell cycle progression, and expression of NF-kappaB in human breast cancer cells MCF-7, MCF-10A, and MDA-MB-231 by ponicidin and oridonin, diterpenoids from the chinese herb Rabdosia rubescens
    Tze Chen Hsieh
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA
    Biochem Biophys Res Commun 337:224-31. 2005
    ..Taken together, these results provide a mechanistic framework for the cellular effects of ponicidin and oridonin in different stage breast cancer cells...
  24. ncbi Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways
    Takayuki Ikezoe
    Department of Hematology and Respiratory Medicine, KMS, Kochi Medical School, Nankoku, 783 8505 Kochi, Japan
    Mol Cancer Ther 4:578-86. 2005
    ..Taken together, oridonin might be useful as adjunctive therapy for individuals with lymphoid malignancies, including the lethal disease adult T-cell leukemia...
  25. ncbi Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway
    Jian Huang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, China
    J Pharmacol Sci 102:305-13. 2006
    ..However, in the presence of FGF-2, Bcl-2 phosphorylation was blocked, and the Ras/Raf/ERK signal pathway was activated and protected against the oridonin-induced apoptosis by the alternative function of promoting of Bcl-2 expression...
  26. ncbi [Chemical constituents of Isodon macrophyllus (II)]
    Zhi an He
    Pharmaceutical Laboratory, Xinxiang Medical College, Xinxiang, Henan Province 453003, China
    Zhong Yao Cai 30:794-6. 2007
    ..To study the chemical constituents of Isodon macrophyllus...
  27. ncbi [Regulation of telomerase activity and cell cycle of K562 cells by oridonin]
    Rui Fang Li
    Henan Institute of Medical Sciences, Zhengzhou University, Zhengzhou 450052, China
    Yao Xue Xue Bao 39:865-8. 2004
    ..To investigate the effect of oridonin (ORI) on telomerase activity and cell cycle of human leukemic cell line K562 cells...
  28. ncbi Determination of oridonin in rat plasma by reverse-phase high-performance liquid chromatography
    Jian Ge
    Wuhan Botanical Garden, The Chinese Academy of Sciences, Wuhan 430074, China
    J Pharm Biomed Anal 43:793-7. 2007
    ..05 microg/mL. The RP-HPLC method was readily applied to quantitate oridonin in rat plasma within 24 h in a pharmacokinetics study where experimental rats received a single dose of oridonin (12.5 mg/kg) and the result was presented...
  29. ncbi Anti-proliferative effects of oridonin on SPC-A-1 cells and its mechanism of action
    J J Liu
    Department of Haematology and Oncology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    J Int Med Res 32:617-25. 2004
    ..We conclude that oridonin demonstrated anti-proliferative and apoptosis-inducing effects on SPC-A-1 cells in vitro, and that changes in bcl-2 and bax protein levels may play an important role in its mechanism of action...
  30. ncbi Novel ent-Beyeran-19-oic acids from biotransformations of isosteviol metabolites by Mortierella isabellina
    Che Ling Lin
    Institute of Traditional Medicine, National Yang Ming University, Taipei, Taiwan
    Planta Med 73:1581-7. 2007
    ..All compounds were evaluated with the cell viability assay. The results of the bioassay indicated that MTT formazan exocytosis occurs upon treatment of the cells with 1...
  31. ncbi Cytotoxic ent-kaurane diterpenoids from Isodon eriocalyx
    Yun Heng Shen
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China
    Chem Biodivers 2:1665-72. 2005
    ..Hara., and their structures were determined by spectroscopic methods. All diterpenoids, except for 3 and 13, were evaluated for inhibition of the K562, T-24, Me180, QGY-7701, and BIU87 cell lines (Table 2)...
  32. ncbi Cytotoxic ent-kauranoids from Isodon parvifolius
    Li Mei Li
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P R China
    Chem Biodivers 3:1031-8. 2006
    ..Compounds 1 and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines...
  33. ncbi [Simultaneous determination of stevioside, rebaudioside A and glycyrrhizic acid in foods by HPLC]
    Narue Sakamaki
    Tama Branch Institute, Tokyo Metropolitan Institute of Public Health, 3 16 25, Shibasaki cho, Tachikawa, Tokyo 190 0023, Japan
    Shokuhin Eiseigaku Zasshi 45:81-6. 2004
    ..The recoveries of Stev, RebA and GA from 8 kinds of foods spiked at the level of 0.1 g/kg were 81.7-101%, 81.5-100% and 78.6-95.0%, respectively. The determination limits were 0.01 g/kg in samples...
  34. ncbi [The tissue distribution in mice and pharmacokinetics in rabbits of oridonin-solid lipid nanoparticles]
    Dian Rui Zhang
    College of Chinese Materia Medica, Beijing University of Traditional Chinese Medicine, Beijing 100102, China
    Yao Xue Xue Bao 40:573-6. 2005
    ..To investigate the tissue distribution and pharmacokinetics of oridonin-solid lipid nanoparticles in animals...
  35. ncbi Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929
    Chun Ling Zhang
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, China
    Biol Pharm Bull 27:1527-31. 2004
    ..These results indicate that regulation of the Bcl-2 and MAPK families maybe the effector mechanisms of oridonin-induced L929 cell death, independent of the caspase pathway...
  36. ncbi [Change of Bcl-2 expression and telomerase during apoptosis induced by oridonin on human hepatocelluar carcinoma cells]
    Jun Feng Zhang
    Department of Liver Transplantation, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Zhongguo Zhong Yao Za Zhi 31:1811-4. 2006
    ..To investigate the change of Bcl-2 expression and telomerase during the apoptosis induced by oridonin on human hepatocelluar carcinoma BEL7402 cells...
  37. ncbi Determination of the diterpenoid, kaurenoic acid, in Annona glabra by HPLC
    Brás H Oliveira
    UFPR, Departamento de Quimica, CP19081, 81531 970, Curitiba PR, Brazil
    Phytochem Anal 13:368-71. 2002
    ..29 +/- 0.23 and 0.27 +/- 0.01 mg/g dry weight, respectively) and lowest in the spring for bark and in the winter for leaves (4.00 +/- 0.25 and 0.11 +/- 0.01 mg/g dry weight, respectively)...
  38. ncbi Mechanism of the antihypertensive effect of stevioside in anesthetized dogs
    Ju Chi Liu
    Department of Medicine, Taipei Medical University Wan Fang Hospital, Taipei, Taiwan
    Pharmacology 67:14-20. 2003
    ..This study confirmed that stevioside is an effective antihypertensive natural product, and its hypotensive mechanism may be probably due to inhibition of the Ca(2+) influx...
  39. ncbi Analysis of rubusoside and related compounds in tenryocha extract sweetener
    Naoki Sugimoto
    National Institute of Health Sciences 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Shokuhin Eiseigaku Zasshi 43:250-3. 2002
    ..Lee (Rosaseae), as determined by comparing TLC and HPLC profiles of the product and hot-water extract prepared from the leaves of R. suavissimus...
  40. ncbi Inhibitory effect of stevioside on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
    Ken Yasukawa
    College of Pharmacy, Nihon University, Chiba, Japan
    Biol Pharm Bull 25:1488-90. 2002
    ..0 and 0.1 mg/mouse of stevioside mixture, the mixture of these compounds markedly inhibited the promoting effect of TPA (1 micro g/mouse) on skin tumor formation initiated with 7,12-dimethylbenz[a]anthracene (50 micro g/mouse)...
  41. ncbi Taibaijaponicains C and D: two new diterpenoids from Isodon japonica
    Bao Lin Li
    School of Chemistry and Material Science, Shaanxi Normal University, Xi an, Shaanxi 710062, China
    Planta Med 68:477-9. 2002
    ....
  42. ncbi Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra
    Jianwen Liu
    State Key Laboratory of Bioreactor Engineering and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China
    Int Immunopharmacol 7:945-54. 2007
    ....
  43. ncbi Diterpenes from Helianthus annuus and their cytotoxicity in vitro
    Mao rong Suo
    Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100094, China
    Yao Xue Xue Bao 42:166-70. 2007
    ..Compounds 1 and 2 are new compounds, some compounds showed cytotoxic activities on SF-268, MCF-7 and HepG2 cell lines...
  44. ncbi Stevioside induces antihyperglycaemic, insulinotropic and glucagonostatic effects in vivo: studies in the diabetic Goto-Kakizaki (GK) rats
    P B Jeppesen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
    Phytomedicine 9:9-14. 2002
    ..In conclusion, stevioside exerts antihyperglycaemic, insulinotropic, and glucagonostatic actions in the type 2 diabetic GK rat, and may have the potential of becoming a new antidiabetic drug for use in type 2 diabetes...
  45. ncbi Without sugar, would the holidays be as sweet? Exploring ethnobotanical alternatives to sucrose
    Roberta Lee
    The Continuum Center for Health and Healing at Beth Israel Medical Center in New York City, USA
    Altern Ther Health Med 8:98-9. 2002
  46. ncbi Inhibitory effect of stevioside on calcium influx to produce antihypertension
    C N Lee
    Department of Medicine, Taipei Medical University-Wan Fang Hospital, Wen Shan, Taipei, Taiwan
    Planta Med 67:796-9. 2001
    ..The present data show that the vasorelexation effect of stevioside was mediated mainly through Ca(2+) influx inhibition...
  47. ncbi [Mechanism of downregulation of apoptosis by autophagy induced by oridonin in HeLa cells]
    Qiao Cui
    China Japan Research Institute of Medical Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    Yao Xue Xue Bao 42:35-9. 2007
    ..Oridonin-induced autophagy antagonized apoptosis in HeLa cells through mitochondrial pathway...
  48. ncbi A new diterpenoid from Fritillaria anhuiensis
    Lu Kang
    Shanghai University of Traditional Chinese Medicine, Shanghai 200233, China
    Yao Xue Xue Bao 42:58-60. 2007
    ..Compound 1 is a new labdane-type diterpenoid. Compounds 2 and 3 were obtained from Fritillaria anhuiensis for the first time...
  49. ncbi In vitro metabolism of the glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora
    E Koyama
    Department of Biology, Kashima Laboratory, Mitsubishi Chemical Safety Institute Ltd, 14 Sunayama, Hasaki machi, Kashima gun, Ibaraki, 314 0255, Japan
    Food Chem Toxicol 41:359-74. 2003
    ..This study suggests that there are apparently no species differences in intestinal metabolism of stevia mixture between rats and humans...
  50. ncbi Autophagy preceded apoptosis in oridonin-treated human breast cancer MCF-7 cells
    Qiao Cui
    China Japan Research Institute of Medical Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang, PR China
    Biol Pharm Bull 30:859-64. 2007
    ..Taken together, oridonin simultaneously induced MCF-7 cells both apoptosis and autophagy, and in this settings, inhibition of autophagy induced lowered apoptotic level, therefore, autophagy participated in upregulation of apoptosis...
  51. ncbi Effects of stevioside on glucose transport activity in insulin-sensitive and insulin-resistant rat skeletal muscle
    Narissara Lailerd
    Muscle Metabolism Laboratory, Department of Physiology, University of Arizona College of Medicine, Tuscon, USA
    Metabolism 53:101-7. 2004
    ..1 mmol/L) modestly improved in vitro insulin action on skeletal muscle glucose transport in both lean and obese Zucker rats. These results indicate that one potential site of action of SVS is the skeletal muscle glucose transport system...
  52. ncbi Stevioside
    Jan M C Geuns
    Laboratory of Plant Physiology, Catholic University of Leuven, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    Phytochemistry 64:913-21. 2003
    ..It is suited for both diabetics, and PKU patients, as well as for obese persons intending to lose weight by avoiding sugar supplements in the diet. No allergic reactions to it seem to exist...
  53. ncbi Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora
    Claudio Gardana
    Department of Food Science and Microbiology, Division of Human Nutrition, University of Milan, Via Celoria 2, 20133 Milan, Italy
    J Agric Food Chem 51:6618-22. 2003
    ..Furthermore, stevioside and rebaudioside A did not significantly influence the composition of fecal cultures; among the selected intestinal groups, bacteroides were the most efficient in hydrolyzing Stevia sweeteners to steviol...
  54. ncbi Antihyperglycemic effects of stevioside in type 2 diabetic subjects
    Søren Gregersen
    Department of Endocrinology and Metabolism C, Aarhus University Hospital, Denmark
    Metabolism 53:73-6. 2004
    ..In conclusion, stevioside reduces postprandial blood glucose levels in type 2 diabetic patients, indicating beneficial effects on the glucose metabolism. Stevioside may be advantageous in the treatment of type 2 diabetes...
  55. ncbi Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol
    Jan M C Geuns
    Laboratory of Plant Physiology, Catholic University of Leuven, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    Food Chem Toxicol 41:1599-607. 2003
    ....
  56. ncbi Effect of stevioside and steviol on the developing broiler embryos
    Jan M C Geuns
    Lab Plant Physiology, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    J Agric Food Chem 51:5162-7. 2003
    ..No stevioside or steviol could be detected in the blood of the hatchlings. The hatchlings developed normally. It is concluded that prenatal exposure to stevioside and steviol is not toxic for the chicken embryo...
  57. ncbi Steviol quantification at the picomole level by high-performance liquid chromatography
    Veerle J Y Minne
    Laboratory of Plant Physiology, Katholieke Universiteit Leuven, Kasteelpark Arenberg 31, B 3001 Leuven, Belgium
    J Agric Food Chem 52:2445-9. 2004
    ..A sensitive determination of 594 ng of steviol present in 100 mg of dry plant material was performed with high precision and accuracy...
  58. ncbi Metabolism of stevioside by chickens
    Jan M C Geuns
    Laboratory of Plant Physiology, Kasteelpark Arenberg 31, Katholieke Universiteit Leuven, B 3001 Leuven, Belgium
    J Agric Food Chem 51:1095-101. 2003
    ..No harmful effects were observed in the chronic stevioside supplementation experiments nor in the intubation experiments in which very high stevioside doses were given...
  59. ncbi Structure-mutagenicity relationship of kaurenoic acid from Xylopia sericeae (Annonaceae)
    B C Cavalcanti
    Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará UFC, CEP 60430 270, Fortaleza, CE, Brazil
    Mutat Res 701:153-63. 2010
    b>Kaurane diterpenes are considered important compounds in the development of new highly effective anticancer chemotherapeutic agents...
  60. ncbi [Diterpenes and other components of Croton hirtus (Euphorbiaceae)]
    J C Fuentes
    Escuela de Química y Centro de Investigación de Productos Naturales, Universidad de Costa Rica, San Jose, Costa Rica
    Rev Biol Trop 52:269-85. 2004
    ..MS fragmentation patterns are here reported. The absolute configurations of 4 and 9 were elucidated by using circular dichroism. The separation was performed with modern chromatographic technics...
  61. ncbi Semisynthetic derivatives of ent-kauranes and their antifeedant activity
    M Bruno
    Department of Organic Chemistry, Palermo University, Viale delle Scienze, Parco D Orleans II, 90128, Palermo, Italy
    Phytochemistry 58:463-74. 2001
    ..These compounds were tested for their antifeedant activity against larvae of Spodoptera littoralis. Although linearol did not influence the feeding behaviour of larvae, some of its derivatives showed significant antifeedant activity...
  62. ncbi Preparation and phytotoxicity of novel kaurane diterpene amides with potential use as herbicides
    Maria Amélia Diamantino Boaventura
    Departamento de Quimica, Instituto de Ciencias Exatas, Universidade Federal de Minas Gerais, Av Antonio Carlos 6627, 31270 901 Belo Horizonte, MG, Brazil
    J Agric Food Chem 56:2985-8. 2008
    ..Amides from symmetrical diamines showed significant inhibitory activity at higher concentrations...
  63. ncbi Comparison of two different solvents employed for pressurised fluid extraction of stevioside from Stevia rebaudiana: methanol versus water
    Jaroslav Pól
    Institute of Analytical Chemistry, Academy of Sciences of the Czech Republic, Veveri 97, 611 42, Brno, Czech Republic
    Anal Bioanal Chem 388:1847-57. 2007
    ..However, water represents the green alternative to methanol. The limit of detection of stevioside in the extract analysed was 30 ng for UV detection and 2 ng for MS detection...
  64. ncbi Effects of tenuifolin extracted from radix polygalae on learning and memory: a behavioral and biochemical study on aged and amnesic mice
    Hong Zhang
    Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China
    Phytomedicine 15:587-94. 2008
    ..This may do so by relatively increasing the levels of NE, DA in the hippocampus and by decreasing the activity of AChE in the cortex...
  65. ncbi Isosteviol increases insulin sensitivity and changes gene expression of key insulin regulatory genes and transcription factors in islets of the diabetic KKAy mouse
    I Nordentoft
    Department of Endocrinology and Metabolism C, Aarhus Sygehus THG, Aarhus University Hospital, Aarhus C, Denmark
    Diabetes Obes Metab 10:939-49. 2008
    ....
  66. ncbi An attempt to enlarge the B ring of maoecrystal B, an ent-kaurane-type diterpene
    L Xu
    Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, No 17, Duan 3, Renmin Nan Road, Chengdu 610041, China
    J Asian Nat Prod Res 8:545-54. 2006
    ..An attempt to enlarge the B ring of maoecrystal B (6), an ent-kaurane-type diterpene from Isodon eriocalyx (Labiatae), to obtain the desired compound 23 via six steps, led to the novel rearranged diterpene compound 22...
  67. ncbi 13-Hydroxy-15-oxo-zoapatlin, an ent-kaurane diterpene, induces apoptosis in human leukemia cells, affecting thiol-mediated redox regulation
    Fabrizio Dal Piaz
    Dipartimento di Scienze Farmaceutiche, Universita di Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Free Radic Biol Med 43:1409-22. 2007
    ..The interaction of OZ with cellular components and proteins containing reactive thiols was evaluated by mass spectrometry-based approaches. A specific reactivity of this compound toward glutathione and thioredoxin was observed...
  68. pmc Down-regulation of androgen-receptor and PSA by phytochemicals
    Sophie Chen
    Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Int J Oncol 32:405-11. 2008
    ..In each case, these compounds have independent activities which may partly contribute to the biological activity of PC-SPES...
  69. ncbi Roles of Ras and extracellular signal-regulated kinase-dependent IkappaBalpha degradation in oridonin-enhanced phagocytosis of apoptotic cells by human macrophage-like U937 cells
    Yan Qiu Liu
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Parmaceutical University, 103 Wenhua Road, Shenyang, Liaoning Province, 110016, PR China
    Int Immunopharmacol 6:260-8. 2006
    ....
  70. ncbi Four ent-kaurane-type diterpenoids from Croton tonkinensis Gagnep
    Phan Minh Giang
    Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi
    Chem Pharm Bull (Tokyo) 52:879-82. 2004
    ..Their structures were elucidated by spectroscopic analyses...
  71. ncbi Structure of kaurane-type diterpenes from Parinari sprucei and their potential anticancer activity
    Alessandra Braca
    Dipartimento di Chimica Bioorganica e Biofarmacia, Universita di Pisa, Pisa, Italy
    Planta Med 70:540-50. 2004
    ..The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used...
  72. ncbi Kaurene diterpene induces apoptosis in human leukemia cells partly through a caspase-8-dependent pathway
    Masuo Kondoh
    Department of Pharmaceutics and Biopharmaceutics, Showa Pharmaceutical University, Machida, Tokyo, 194 8543, Japan
    J Pharmacol Exp Ther 311:115-22. 2004
    ..Thus, KD may be a promising experimental cytotoxic agent that possibly points to new strategies to overcome a drug resistance...
  73. ncbi NMR studies of the conformation of the natural sweetener rebaudioside A
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, United States
    Carbohydr Res 344:2533-8. 2009
    ..Hydrogen bonding was examined using the temperature coefficients of the hydroxyl chemical shifts, ROESY and long-range COSY spectra, and proton-proton coupling constants...
  74. ncbi Stevioside inhibits atherosclerosis by improving insulin signaling and antioxidant defense in obese insulin-resistant mice
    B Geeraert
    Atherosclerosis and Metabolism Unit, Department of Cardiovascular Diseases and Leuven Food Science and Nutrition Research Centre, Katholieke Universiteit Leuven, Leuven, Belgium
    Int J Obes (Lond) 34:569-77. 2010
    ..Therefore, we investigated its effects on insulin resistance, inflammation and oxidative stress related to atherosclerosis in obese insulin-resistant mice...
  75. pmc Identification and functional characterization of monofunctional ent-copalyl diphosphate and ent-kaurene synthases in white spruce reveal different patterns for diterpene synthase evolution for primary and secondary metabolism in gymnosperms
    Christopher I Keeling
    Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia V6T 1Z4, Canada
    Plant Physiol 152:1197-208. 2010
    ..In contrast, diTPSs for specialized metabolism have evolved differently in angiosperms and gymnosperms...
  76. ncbi New ent-kaurene-type diterpenoids possessing cytotoxicity from the New Zealand liverwort Jungermannia species
    Fumihiro Nagashima
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro cho, Japan
    Chem Pharm Bull (Tokyo) 51:1189-92. 2003
    ..Their structures were established based on extensive NMR techniques...
  77. ncbi Ent-kaurane diterpenoids from Isodon rubescens var. lushanensis
    Quan Bin Han
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
    Chem Pharm Bull (Tokyo) 51:790-3. 2003
    ..lushanensis, and the structures were elucidated by spectroscopic analysis. The inhibitory effect against the K562, Bcap37, BGC823, BIU87, CA, CNE, and Hela cell lines of compounds 3 and 5-10 were evaluated...
  78. ncbi Four new ent-kaurane diterpenoids from the fruits of Annona cherimola
    Hiroyuki Miyashita
    Faculty of Pharmaceutical Sciences, Sojo University, 4 22 1 Ikeda, Kumamoto 862 0082, Japan
    Chem Pharm Bull (Tokyo) 58:765-8. 2010
    ..Their structures are determined on the basis of spectroscopic data and optical rotation...
  79. ncbi [Genotoxicity studies of stevia extract and steviol by the comet assay]
    Kaoru Sekihashi
    Safety Research Institute for Chemical Compounds Co, Ltd, 363 24 Shin ei, Kiyota ku, Sapporo 004 0839, Japan
    J Toxicol Sci 27:1-8. 2002
    ..Stomach, colon and liver DNA were not damaged. As all studies showed negative responses, stevia extract and steviol are concluded to not have DNA-damaging activity in cultured cells and mouse organs...
  80. ncbi ent-Kaurene diterpenoids from Blepharispermum hirtum
    Majekodunmi O Fatope
    Department of Chemistry, College of Science, Sultan Qaboos University, P O Box 36, Al Khod 123, Muscat, Sultanate of Oman
    Chem Biodivers 7:1862-70. 2010
    ..5 microg/ml. The significance of the bioactivity results and the presence of ent-kaurene diterpenoids in B. hirtum are discussed from biosynthetic and local utilization viewpoints...
  81. ncbi Neuroprotective Kaurane Diterpenes from Fritillaria ebeiensis
    Jing Xu
    College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, China
    Biosci Biotechnol Biochem 75:1386-8. 2011
    The new kaurane diterpene, ent-3β-butanoyloxykaur-15-en-17-ol, and four known kaurane diterpenes were isolated from the bulbs of Fritillaria ebeiensis...
  82. ncbi Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor
    Bo Hon Chou
    Department of Medicinal Chemistry, College of Pharmacy, Taipei Medical University, Taipei 110, Taiwan
    Phytochemistry 70:759-64. 2009
    ..7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone...
  83. ncbi A new ent-kaurane type diterpenoid glycoside from Inula japonica Thunb
    Jiang Jiang Qin
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
    Arch Pharm Res 32:1369-72. 2009
    ..In addition, 4 exhibited significant inhibitory activity on NO production in LPS-stimulated RAW264.7 cells with IC(50) value of 14.3 microg/mL...
  84. ncbi Cytotoxic ent-kaurane diterpenoids from Isodon henryi
    Yong Zhao
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China
    Planta Med 75:65-9. 2009
    ..50 microg/mL. Isolates 1-5 were evaluated against the K562 cell line, and only 3 showed weak activity...
  85. ncbi Validated high-performance thin-layer chromatography method for steviol glycosides in Stevia rebaudiana
    Vikas Jaitak
    Natural Plant Products Division, Institute of Himalayan Bioresource Technology CSIR, Palampur 176061, H P, India
    J Pharm Biomed Anal 47:790-4. 2008
    ..rebaudiana leaves collected from ten different locations and will serve as a quality control indicator to monitor the commercial production of stevioside and its allied molecules during different stages of its processing...
  86. ncbi Stevioside is a novel stimulator of pharmacon clathration with glycosides
    T G Tolstikova
    Novosibirsk Institute of Organic Chemistry, Siberian Division, Russian Academy of Sciences, pr akademika Lavrent eva 9, Novosibirsk, 630090 Russia
    Dokl Biol Sci 403:244-6. 2005
  87. pmc Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
    Yu Du
    Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, Arizona, USA
    Environ Health Perspect 116:1154-61. 2008
    ..Recently, activation of the Nrf2 signaling pathway has been reported to confer protection against arsenic-induced toxicity in a cell culture model...
  88. ncbi Increase of insulin sensitivity by stevioside in fructose-rich chow-fed rats
    J C Chang
    Department of Food Science, National Pingtung University of Science and Technology, Pingtung City, Taiwan, R O C
    Horm Metab Res 37:610-6. 2005
    ..Taken together, this demonstrated that oral administration of stevioside improves insulin sensitivity, and seems suitable as an adjuvant for diabetic patients and/or those that consume large amounts of fructose...
  89. ncbi Comparative toxicokinetics and metabolism of rebaudioside A, stevioside, and steviol in rats
    A Roberts
    Cantox Health Sciences International, 2233 Argentia Road, Suite 308, Mississauga, Ontario, Canada L5N 2X7
    Food Chem Toxicol 46:S31-9. 2008
    ..These studies support the use of toxicological safety studies conducted with stevioside for the safety assessment of rebaudioside A...
  90. ncbi ent-kaurane diterpenoids from the liverwort Jungermannia atrobrunnea
    Jian Bo Qu
    Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No 44 West Wenhua Road, Jinan 250012, People s Republic of China
    J Nat Prod 71:1418-22. 2008
    ..The absolute configurations of these compounds were clarified by CD spectroscopic studies. Compound 1 is the first example of a rearranged ent-kaurane diterpenoid possessing a peroxide bridge...
  91. ncbi Hydroxylation at carbon-2 of ent-16-oxo-17-norkauran-19-oic acid by Fusarium proliferatum
    Alessandra Duarte Rocha
    Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    J Nat Prod 73:1431-3. 2010
    ..This is the first time that fungal hydroxylation at position C-2 has been reported on an ent-kaurane diterpene skeleton...
  92. ncbi Cardiovascular and diuretic activity of kaurene derivatives of Xylopia aethiopica and Alepidea amatymbica
    L I Somova
    Department of Human Physiology, University of Durban Westville, Private Bag X54001, Durban, South Africa
    J Ethnopharmacol 77:165-74. 2001
    ..Further experiments are needed to elaborate the exact mechanisms of the hypotensive and diuretic effects of diterpene kaurenoids...
  93. ncbi Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro
    Geneive E Henry
    Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA
    Cancer Lett 244:190-4. 2006
    ..03microg/mL) and 1b (IC(50) 6.81microg/mL), and LNCaP towards 2 (IC(50) 12.83microg/mL) and 4 (IC(50) 17.63microg/mL)...
  94. ncbi Diterpenoids
    James R Hanson
    Department of Chemistry, University of Sussex, Brighton, Sussex BN1 9QJ, UK
    Nat Prod Rep 24:1332-41. 2007
    ..This review covers the isolation and structures of diterpenoids including labdanes, clerodanes, pimaranes, abietanes, kauranes, cembranes, taxanes and marine diterpenoids; 173 references are cited...
  95. ncbi [Isolation and identification of two new diterpenoid from Rubus corchorifolius L. f]
    Min Zhang
    College of Biological Science and Technology, Hunan Agriculture University, Changsha 410128, China
    Yao Xue Xue Bao 42:1155-8. 2007
    ..f. Their structures were identified as ent-kauran-3beta, 16beta, 17, 19-tetrol (1), ent-2-carbonyl-16beta-hydroxy-kauran-17-beta-D-glucoside (2). Compounds 1 and 2 are new compounds...
  96. ncbi Microbial hydrolysis of steviol glycosides
    A G Renwick
    School of Medicine, University of Southampton, UK
    Food Chem Toxicol 46:S70-4. 2008
    ....
  97. ncbi Efficacy and tolerability of oral stevioside in patients with mild essential hypertension: a two-year, randomized, placebo-controlled study
    Ming Hsiung Hsieh
    Department of Medicine, Taipei Medical University Wan Fang Hospital, Taipei City, Taiwan
    Clin Ther 25:2797-808. 2003
    ..Previous animal and human studies have indicated that stevioside has an antihypertensive effect...
  98. ncbi Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Life Sci 77:2127-40. 2005
    ..0%). The relationship between the structure of stevioside-based compounds and these activities were discussed...
  99. ncbi Oridonin-induced A431 cell apoptosis partially through blockage of the Ras/Raf/ERK signal pathway
    Dan Li
    China Japan Research Institute of Medical and Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110 016, P R China
    J Pharmacol Sci 103:56-66. 2007
    ..Taken together, oridonin-induced apoptosis in A431 cells might be through blocking EGFR and its downstream Ras/Raf/ERK signal pathway...
  100. ncbi Cytotoxic diterpenoids and sesquiterpenoids from Pteris multifida
    Xin Ge
    Central Research Institute of Shanghai Pharmaceutical Group, Shanghai 201203, People s Republic of China
    J Nat Prod 71:227-31. 2008
    ..The structures of 1- 6 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Compounds 4 and 5 showed cytotoxicity against the HepG2 tumor cell line with IC 50 values of less than 10 microM...
  101. ncbi Genotoxicity studies on a high-purity rebaudioside A preparation
    Lonnie D Williams
    Burdock Group, 801 N Orange Ave, Suite 710, Orlando, FL 32801, USA
    Food Chem Toxicol 47:1831-6. 2009
    ..These studies provide additional evidence that Reb A is not genotoxic at the doses tested and further support the generally recognized as safe determination of Reb A...

Research Grants1

  1. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..