diterpenes

Summary

Summary: Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.

Top Publications

  1. ncbi Triptolide and its expanding multiple pharmacological functions
    Qiuyan Liu
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Int Immunopharmacol 11:377-83. 2011
  2. ncbi Cytotoxic and anti-inflammatory cembranoids from the soft coral Lobophytum crassum
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1819-24. 2008
  3. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  4. ncbi Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 72:152-5. 2009
  5. pmc Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells
    Tzu rong Su
    Antai Medical Care Cooperation, Antai Tian Sheng Memorial Hospital, Pingtung 92842, Taiwan
    Mar Drugs 10:1883-98. 2012
  6. ncbi Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 73:1184-7. 2010
  7. ncbi Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum
    Shih Tseng Lin
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Org Lett 11:3012-4. 2009
  8. pmc Bioactive cembranoids from the soft coral Sinularia crassa
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:1955-68. 2011
  9. pmc Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi
    Chi Jen Tai
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:2036-45. 2011
  10. pmc Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular
    Jui Hsin Su
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 9:944-51. 2011

Detail Information

Publications343 found, 100 shown here

  1. ncbi Triptolide and its expanding multiple pharmacological functions
    Qiuyan Liu
    National Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, China
    Int Immunopharmacol 11:377-83. 2011
    ..Importantly, PG490-88 has been approved entry into Phase I clinical trial for treatment of prostate cancer in USA. This review will focus on these breakthrough findings of triptolide and its implications...
  2. ncbi Cytotoxic and anti-inflammatory cembranoids from the soft coral Lobophytum crassum
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1819-24. 2008
    ..Compounds 1, 3, 7, and 10 were found to inhibit the accumulation of the pro-inflammatory proteins iNOS and COX-2 at 10 μM...
  3. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  4. ncbi Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 72:152-5. 2009
    ..Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro...
  5. pmc Induction of apoptosis by 11-dehydrosinulariolide via mitochondrial dysregulation and ER stress pathways in human melanoma cells
    Tzu rong Su
    Antai Medical Care Cooperation, Antai Tian Sheng Memorial Hospital, Pingtung 92842, Taiwan
    Mar Drugs 10:1883-98. 2012
    ..The data in this study suggest that 11-dehydrosinulariolide potentially induces apoptosis against melanoma cells via mitochondrial dysregulation and ER stress pathways...
  6. ncbi Antiviral and anti-inflammatory diterpenoids from the soft coral Sinularia gyrosa
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 73:1184-7. 2010
    ..6 and 3.7 microM, respectively. In addition, compounds 1 and 2 showed significant anti-inflammatory activity by reducing the levels of the COX-2 protein (19.6 + or - 3.9% and 29.1 + or - 9.6%, respectively) in RAW 264.7 macrophages...
  7. ncbi Lobocrasol, a new diterpenoid from the soft coral Lobophytum crassum
    Shih Tseng Lin
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Org Lett 11:3012-4. 2009
    ..Lobocrasol (1), possessing an unprecedented diterpenoid skeleton, was isolated from the soft coral Lobophytum crassum. The structure of lobocrasol was established by extensive analysis of spectroscopic data...
  8. pmc Bioactive cembranoids from the soft coral Sinularia crassa
    Chih Hua Chao
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:1955-68. 2011
    ....
  9. pmc Bioactive eunicellin-based diterpenoids from the soft coral Cladiella krempfi
    Chi Jen Tai
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:2036-45. 2011
    ..Furthermore, compounds 2, 3, 5 and 6 were shown to exert significant in vitro anti-inflammatory activity against LPS-stimulated RAW264.7 macrophage cells...
  10. pmc Bioactive cembrane-based diterpenoids from the soft coral Sinularia triangular
    Jui Hsin Su
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 9:944-51. 2011
    ..7 macrophage cells by inhibiting the expression of the iNOS protein. Metabolites 4 and 5 also effectively reduced the expression of the COX-2 protein in the macrophages...
  11. ncbi Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity
    C Cavin
    Food Safety Group, Nestle Research Center, PO Box 44, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Food Chem Toxicol 40:1155-63. 2002
    ..In animal models and cell culture systems, the coffee diterpenes cafestol and kahweol (C+K) were shown to produce a broad range of biochemical effects resulting in a reduction ..
  12. pmc Cytotoxic and anti-inflammatory eunicellin-based diterpenoids from the soft coral Cladiella krempfi
    Chi Jen Tai
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 11:788-99. 2013
    ..Furthermore, compounds 6 and 10 could potently inhibit the accumulation of the pro-inflammatory iNOS protein, and 6 and 12 could significantly reduce the expression of COX-2 protein in LPS-stimulated RAW264.7 macrophage cells...
  13. pmc Discovery of new eunicellins from an Indonesian octocoral Cladiella sp
    Yung Husan Chen
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 9:934-43. 2011
    ..The previously reported structures of two eunicellin-based compounds, cladielloides A and B, are corrected in this study...
  14. ncbi Bioactive norditerpenoids from the soft coral Sinularia gyrosa
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Bioorg Med Chem 18:3379-86. 2010
    ..6+/-4.6%, 66.9+/-5.2%, 10.2+/-5.1%, 17.4+/-7.2%, 47.2+/-11.9%, and 56.3+/-5.1%, respectively) by LPS stimulation. Compound 8 showed significant antiviral activity against HCMV (human cytomegalovirus) cells with an IC(50) of 1.9microg/mL...
  15. pmc Triptolide downregulates Rac1 and the JAK/STAT3 pathway and inhibits colitis-related colon cancer progression
    Zhipeng Wang
    Department of Pharmacology, School of Pharmacy, The Fourth Military Medical University, Shaanxi Province 710032, China
    Exp Mol Med 41:717-27. 2009
    ..This suggests that triptolide might be a candidate for prevention of colitis induced colon cancer because it reduces inflammation and prevents tumor formation and development...
  16. ncbi Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy
    Qing Gao
    Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    Nephrol Dial Transplant 25:3539-47. 2010
    ..Herein, we investigated the therapeutic effects of triptolide on DN in db/db diabetic mice and studied the potential mechanisms...
  17. pmc Molecular understanding and modern application of traditional medicines: triumphs and trials
    Timothy W Corson
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA
    Cell 130:769-74. 2007
    ..Here, we highlight the challenges along this route, focusing on the compounds artemisinin, triptolide, celastrol, capsaicin, and curcumin...
  18. ncbi Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms
    Zhao Li Zhou
    Division of Antitumor Pharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi Tech Park, Shanghai, 201203, P R China
    Nat Prod Rep 29:457-75. 2012
    ..This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years...
  19. pmc Cladielloides A and B: new eunicellin-type diterpenoids from an Indonesian octocoral Cladiella sp
    Yung Husan Chen
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Mar Drugs 8:2936-45. 2010
    ..Cladielloide B (2) exhibited moderate cytotoxicity toward CCRF-CEM tumor cells and this compound displayed significant inhibitory effects on superoxide anion generation and elastase release by human neutrophils...
  20. ncbi Anti-inflammatory cembranoids from the soft corals Sinularia querciformis and Sinularia granosa
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 71:1754-9. 2008
    ..However, compounds 3, 7, and 8 significantly inhibited the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  21. ncbi Simplexins A-I, eunicellin-based diterpenoids from the soft coral Klyxum simplex
    Shwu Li Wu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 72:994-1000. 2009
    ..Compound 5 was shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells...
  22. ncbi Pachycladins A-E, prostate cancer invasion and migration inhibitory Eunicellin-based diterpenoids from the red sea soft coral Cladiella pachyclados
    Hossam M Hassan
    Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, Louisiana 71201, USA
    J Nat Prod 73:848-53. 2010
    ..are among the important marine invertebrate classes that produce a wealth of chemically diverse bioactive diterpenes. Examples of these are the potent microtubule disruptor sarcodictyins and eleutherobin...
  23. ncbi Anti-inflammatory eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
    Bo Wei Chen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Org Biomol Chem 8:2363-6. 2010
    ..7 macrophage cells. Compound 3 also showed marked activity in inhibiting the expression of COX-2 protein in the same cells...
  24. ncbi Klysimplexins I-T, eunicellin-based diterpenoids from the cultured soft coral Klyxum simplex
    Bo Wei Chen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Org Biomol Chem 9:834-44. 2011
    ..7 macrophage cells by inhibiting the expression of the iNOS protein. Compounds 10 and 11 also could effectively reduce the level of COX-2 protein...
  25. ncbi Triptolide inhibits the growth and metastasis of solid tumors
    Shanmin Yang
    Department of Oncology, Georgetown University Medical Center, Washington, DC 20007, USA
    Mol Cancer Ther 2:65-72. 2003
    ..Taken together, these results suggest that TPL has several attractive features as a new antitumor agent...
  26. ncbi Diterpenes from gorgonian corals
    Fabrice Berrue
    Department of Chemistry, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, C1A 4P3, Canada
    Nat Prod Rep 26:681-710. 2009
    ..demonstrated to contain a wide variety of natural products including steroids, acetogenins, sesquiterpenes and diterpenes. The most common of the gorgonian natural products are the diterpenes, and the intent of this review is to ..
  27. ncbi Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune response
    Robert H Rosen
    Southern Suburbs Dermatology, Sydney, Australia
    J Am Acad Dermatol 66:486-93. 2012
    ..The subsequent immune-mediated response targets any residual dysplastic epidermal cells. This dual mechanism of action should provide efficacy equivalent to that of current topical agents with a substantially shorter treatment period...
  28. ncbi Cytotoxic and anti-inflammatory cembranoids from the Dongsha Atoll soft coral Sarcophyton crassocaule
    Wan Yu Lin
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Bioorg Med Chem 18:1936-41. 2010
    ..Compounds 1-4, 6 and 8 were shown to exert significant in vitro anti-inflammatory activity in LPS-stimulated RAW264.7 macrophage cells. Compound 6 also significantly inhibited the accumulation of pro-inflammatory COX-2 protein...
  29. ncbi Pseudolaric acid B induces apoptosis, senescence, and mitotic arrest in human breast cancer MCF-7
    Jing Hua Yu
    China Japan Research Institute of Medical Pharmaceutical Sciences, Shenyang Pharmaceutical University, Shenyang 110016, China
    Acta Pharmacol Sin 28:1975-83. 2007
    ..The aim of the present study was to investigate the inhibitory effect of pseudolaric acid B (PAB) on human breast cancer MCF-7 cells...
  30. pmc New cytotoxic cembranolides from the soft coral Lobophytum michaelae
    Shang Kwei Wang
    Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Mar Drugs 10:306-18. 2012
    ..Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated...
  31. ncbi Proteomic profiling of the 11-dehydrosinulariolide-treated oral carcinoma cells Ca9-22: effects on the cell apoptosis through mitochondrial-related and ER stress pathway
    Chih I Liu
    Department of Nursing, Meiho University, Pingtung, Taiwan
    J Proteomics 75:5578-89. 2012
    ..The significance of these studies illustrates the potential development of anticancer drugs from the natural derivatives of soft coral...
  32. ncbi Hirsutalins A-H, eunicellin-based diterpenoids from the soft coral Cladiella hirsuta
    Bo Wei Chen
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 73:1785-91. 2010
    ..7 macrophage cells by inhibiting the expression of the iNOS protein, with compound 2 also effectively reducing the level of COX-2 protein...
  33. pmc Lobocrassins A-E: new cembrane-type diterpenoids from the soft coral Lobophytum crassum
    Chia Ying Kao
    Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
    Mar Drugs 9:1319-31. 2011
    ..Lobocrassin B (2) exhibited modest cytotoxicity toward K562, CCRF-CEM, Molt4, and HepG2 tumor cells and displayed significant inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils...
  34. pmc The skin cancer chemotherapeutic agent ingenol-3-angelate (PEP005) is a substrate for the epidermal multidrug transporter (ABCB1) and targets tumor vasculature
    Luowei Li
    Laboratory of Cancer Biology and Genetics, Laboratory of Cell Biology, and Confocal Core Facility, Center for Cancer Research, National Cancer Institute and NIH Chemical Genomics Center, National Human Genome Research Institute, NIH, Bethesda, Maryland, USA
    Cancer Res 70:4509-19. 2010
    ..Taken together, our results suggest that P-gp-mediated absorptive transport, dermal penetration, and vascular damage contribute to the anticancer activity of Ing3A in vivo...
  35. ncbi Klymollins A-H, bioactive eunicellin-based diterpenoids from the formosan soft coral Klyxum molle
    Fang Jung Hsu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 74:2467-71. 2011
    ..7 macrophage cells...
  36. pmc New lobane and cembrane diterpenes from two comorian soft corals
    Isabelle Bonnard
    Laboratoire de Chimie des Biomolécules et de l Environnement, Centre de Phytopharmacie, Universite de Perpignan, Perpignan Cedex, France
    Mar Drugs 8:359-72. 2010
    ..The structures of compounds 1-3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase...
  37. ncbi Oxygenated cembranoids from the cultured and wild-type soft corals Sinularia flexibilis
    Jui Hsin Su
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Chem Pharm Bull (Tokyo) 57:1189-92. 2009
    ..The metabolites 5 and 6 have been shown to exhibit weak cytotoxic activity against MCF-7 cancer cell line...
  38. pmc An investigation into the cytotoxic effects of 13-acetoxysarcocrassolide from the soft coral Sarcophyton crassocaule on bladder cancer cells
    Ching Chyuan Su
    Antai Medical Care Cooperation Antai Tian Sheng Memorial Hospital, Pingtung, Taiwan
    Mar Drugs 9:2622-42. 2011
    ..Moreover, it suggests that PPT1 and hnRNP F could be new biomarkers for bladder cancer. The results of this study are also helpful for the diagnosis, progression monitoring and therapeutic strategies of transitional cell tumors...
  39. pmc Cembranoids from the Dongsha Atoll soft coral Lobophytum crassum
    Shih Tseng Lin
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Mar Drugs 9:2705-16. 2011
    ..The cytotoxicity and anti-HCMV (Human cytomegalovirus) activities of 1-4 were evaluated in vitro. Compound 4 exhibited cytotoxicity against A-549 (human lung carcinoma) cell line with an ED(50) of 3.6 μg/mL...
  40. pmc New cembranolides from the Dongsha Atoll soft coral Lobophytum durum
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:1307-18. 2011
    ..8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL...
  41. ncbi Manaarenolides A-I, diterpenoids from the soft coral Sinularia manaarensis
    Jui Hsin Su
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:1134-9. 2006
    ..Among these metabolites, diterpenes (1, 2, 5, and 6) were discovered for the first time as the hydroperoxycembranolides possessing a delta-lactone ..
  42. ncbi Anti-inflammatory cembranolides from the soft coral Lobophytum durum
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Bioorg Med Chem 17:3763-9. 2009
    ..8+/-0.6% and 5.7+/-2.2%, respectively, and COX-2 protein to 47.8+/-9.0% and 71.6+/-5.8%, respectively. Metabolites 1-8 (100 microg/disk) exhibited weak antibacterial activity against Salmonella enteritidis...
  43. ncbi Oxygenated cembranoids from a Formosan soft coral Sinularia gibberosa
    Atallah F Ahmed
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Replublic of China
    J Nat Prod 71:179-85. 2008
    ..None of these compounds were found to be cytotoxic toward a limited panel of cancer cell lines. Compound 1 significantly inhibited the accumulation of the pro-inflammatory COX-2 protein of the LPS-stimulated RAW264.7 macrophage cells...
  44. pmc Bioactive cembranoids from the dongsha atoll soft coral Sarcophyton crassocaule
    Wan Yu Lin
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Mar Drugs 9:994-1006. 2011
    ..7 macrophage cells by inhibiting the expression of the iNOS protein. Compound 4 was also found to effectively reduce the level of COX-2 protein...
  45. ncbi Cembranoids from the soft corals Sinularia granosa and Sinularia querciformis
    Yi Lu
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung, Taiwan
    Chem Pharm Bull (Tokyo) 58:464-6. 2010
    ..Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells...
  46. pmc Medicinal chemistry and pharmacology of genus Tripterygium (Celastraceae)
    Anita M Brinker
    Biotechnology Center for Agriculture and the Environment, Foran Hall, Cook College, Rutgers, The State University of New Jersey, 59 Dudley Road, New Brunswick, NJ 08901 8520, USA
    Phytochemistry 68:732-66. 2007
    ..This review discusses the biochemical composition and biological and pharmacological activities of Tripterygium extracts, and their main bioactive components...
  47. ncbi Identification of a biosynthetic gene cluster in rice for momilactones
    Kazuhiro Shimura
    Biotechnology Research Center, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, Japan
    J Biol Chem 282:34013-8. 2007
    ..These results provide strong evidence for the presence on chromosome 4 of a gene cluster involved in momilactone biosynthesis...
  48. pmc Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways
    Nameeta Mujumdar
    Division of Basic and Translational Research, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Gastroenterology 139:598-608. 2010
    ..We previously showed that triptolide inhibits the growth of pancreatic cancer cells in vitro and prevents tumor growth in vivo. This study investigates the mechanism by which triptolide kills pancreatic cancer cells...
  49. ncbi Cembranoids from the octocoral Sarcophyton ehrenbergi
    Shi Yie Cheng
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 73:197-203. 2010
    ..Moreover, metabolites 1-6 were evaluated in vitro for their cytotoxicity against selected cancer and normal cells lines, antiviral activity against human cytomegalovirus, and antibacterial activity against Salmonella enteritidis...
  50. ncbi Sinulaflexiolides A-K, cembrane-type diterpenoids from the chinese soft coral Sinularia flexibilis
    Ting Wen
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People s Republic of China
    J Nat Prod 71:1133-40. 2008
    ..Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 microM, respectively...
  51. pmc CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice
    Sivakumar Swaminathan
    Department of Biochemistry, Iowa State University, Ames, Iowa 50011, USA
    Plant Cell 21:3315-25. 2009
    ....
  52. ncbi Anticancer and immunostimulatory compounds from Andrographis paniculata
    R Ajaya Kumar
    Discovery Research, Dr Reddy s Laboratories, Miyapur, Hyderabad 500050, India
    J Ethnopharmacol 92:291-5. 2004
    ..Andrographolide showed anticancer activity on diverse cancer cells representing different types of human cancers. Whereas all the three molecules showed enhanced proliferation and interleukin-2 (IL-2) induction in HPBLs...
  53. pmc Proteomic analysis of anti-tumor effects of 11-dehydrosinulariolide on CAL-27 cells
    Chih I Liu
    Department of Nursing, Meiho Universtity, Pingtung 91202, Taiwan
    Mar Drugs 9:1254-72. 2011
    ....
  54. ncbi Triptolide induces pancreatic cancer cell death via inhibition of heat shock protein 70
    Phoebe A Phillips
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55488, USA
    Cancer Res 67:9407-16. 2007
    ..Triptolide is a potential therapeutic agent that can be used to prevent the progression and metastases of pancreatic cancer...
  55. ncbi New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity
    Pei Wen Hsieh
    Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
    Nat Prod Res 17:409-18. 2003
    ..The structure of compound 1 was further confirmed by X-ray analysis. In addition, the isolated cembranolides and the analogues under went a cytotoxicity assay, and the structure-activity relationship (SAR) of these compounds was studied...
  56. ncbi Structural and stereochemical studies of alpha-methylene-gamma-lactone-bearing cembrane diterpenoids from a south china sea soft coral Lobophytum crassum
    Wen Zhang
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhang Jiang Hi Tech Park, Shanghai, 201203, People s Republic of China
    J Nat Prod 71:961-6. 2008
    ..In a bioassay, sinularolides B and C (1 and 2) and new cembranoids 7 and 8 showed in vitro cytotoxicity against the tumor cell lines A-549 and P-388...
  57. ncbi Triptolide inhibits Bcr-Abl transcription and induces apoptosis in STI571-resistant chronic myelogenous leukemia cells harboring T315I mutation
    Xianping Shi
    Department of Pathophysiology, Zhongshan School of Medicine, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou, China
    Clin Cancer Res 15:1686-97. 2009
    ..In the present study, we investigated the effect of triptolide on cell survival or apoptosis in CML cells bearing Bcr-Abl-T315I or wild-type Bcr-Abl...
  58. pmc Heat shock protein 70 inhibits apoptosis in cancer cells through simultaneous and independent mechanisms
    Vikas Dudeja
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Gastroenterology 136:1772-82. 2009
    ..We aimed to elucidate the mechanism by which HSP70 inhibits apoptosis in cancer cells...
  59. ncbi Lysis of cyanobacteria with volatile organic compounds
    Keiko Ozaki
    Graduate School of Environmental and Human Science, Meijo University, Tempaku, Nagoya 468 8503, Japan
    Chemosphere 71:1531-8. 2008
    ..This color change is similar to the phenomenon observed when a sudden decline in growth of cyanobacteria begins in a natural environment...
  60. ncbi The chemistry of marine furanocembranoids, pseudopteranes, gersolanes, and related natural products
    Paul A Roethle
    Department of Chemistry, University of California, Berkeley, CA, USA
    Nat Prod Rep 25:298-317. 2008
    ..An overview of the chemistry and biology of the diterpene natural products known as the furanocembranoids, pseudopteranes, and gersolanes is provided; 85 references are cited...
  61. ncbi Effect of intravesical Resiniferatoxin (RTX) on lower urinary tract symptoms, urodynamic parameters, and quality of life of patients with urodynamic increased bladder sensation
    Apostolos Apostolidis
    The National Hospital for Neurology and Neurosurgery, Department of Uro Neurology, Internal mailbox 71, Queen Square, London WC1N 3BG, UK
    Eur Urol 50:1299-305. 2006
    ..We investigated the efficacy of intravesical RTX in patients with urgency and frequency due to increased bladder sensation...
  62. ncbi Triptolide, a diterpenoid triepoxide, suppresses inflammation and cartilage destruction in collagen-induced arthritis mice
    Na Lin
    Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No 16, Nanxiaojie, Dongzhimennei, Beijing 100700, China
    Biochem Pharmacol 73:136-46. 2007
    ..These results suggest that triptolide exerts novel chondroprotective and anti-inflammatory effects on RA, and the therapeutic action of TWHF on RA is, in part, due to the triptolide activities...
  63. ncbi Furanocembranoids from the soft corals Sinularia asterolobata and Litophyton arboreum
    Daniela Grote
    Lehrstuhl für Organische Chemie, NW II, Universitat Bayreuth, D 95440 Bayreuth
    Chem Biodivers 5:2449-56. 2008
    ..The structures were elucidated primarily by NMR spectroscopy. The furanocembranoids 2, 4, and 5 show good antiproliferative activities against the cell lines L-929 and K-562, and weak cytotoxic effects on HeLa cells...
  64. ncbi Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse
    Mirentxu I Iruretagoyena
    Departamento de Genetica Molecular y Microbiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Alameda 340, Santiago, Chile
    J Pharmacol Exp Ther 312:366-72. 2005
    ..Our data suggest that andrographolide is able to efficiently block T cell activation in vitro, as well as in vivo, a feature that could be useful for interfering with detrimental T cell responses...
  65. ncbi Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway
    Yi Chieh Lee
    Department of Biological Science and Technology and Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan
    Eur J Pharmacol 632:23-32. 2010
    ..These findings suggested that the inhibition on MMP-7 expression by andrographolide may be through suppression on PI3K/Akt/AP-1 signaling pathway, which in turn led to the reduced invasiveness of the cancer cells...
  66. pmc Topical application of marine briarane-type diterpenes effectively inhibits 12-O-tetradecanoylphorbol-13-acetate-induced inflammation and dermatitis in murine skin
    Wen Chi Wei
    Agricultural Biotechnology Research Center, Academia Sinica, Taiwan
    J Biomed Sci 18:94. 2011
    ..In this study, the inhibitory effect of briarane-type diterpenes (BrDs) from marine coral Briareum excavatum on TPA-induced dermatitis and dendritic cell (DC) function was ..
  67. ncbi Anticancer efficacy of 5F in NNK-induced lung cancer development of A/J mice and human lung cancer cells
    Ming yue Li
    Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong
    J Mol Med (Berl) 88:1265-76. 2010
    ..Collectively, 5F is effective against lung cancer in vivo with minimal side effects. It induces apoptosis in lung cancer through the mitochondrial-mediated pathway, in which the activation of ERK is critical...
  68. ncbi Sinuladiterpenes A-F, new cembrane diterpenes from Sinularia flexibilis
    Kuang Liang Lo
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Chem Biodivers 6:2227-35. 2009
    Chromatographic investigation of the octocoral Sinularia flexibilis afforded six new cembrane diterpenes, sinuladiterpenes A-F (1-6, resp...
  69. pmc Triptolide inhibits MDM2 and induces apoptosis in acute lymphoblastic leukemia cells through a p53-independent pathway
    Mei Huang
    Department of Pediatrics, AFLAC Cancer and Blood Disorders Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Ther 12:184-94. 2013
    ..These results suggest that increased inhibition of XIAP due to downregulation of MDM2 may play a critical role in triptolide-induced apoptosis in MDM2-overexpressing cancers...
  70. ncbi Ingenol mebutate field-directed treatment of UVB-damaged skin reduces lesion formation and removes mutant p53 patches
    Sarah Jane Cozzi
    Department of Immunology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    J Invest Dermatol 132:1263-71. 2012
    ..Field-directed treatment may be particularly suitable for patients who have AKs surrounded by UV-damaged skin...
  71. pmc Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells
    L A Birder
    Laboratory of Epithelial Cell Biology, Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Proc Natl Acad Sci U S A 98:13396-401. 2001
  72. ncbi Cytotoxic and anti-inflammatory cembranoids from the Vietnamese soft coral Lobophytum laevigatum
    Tran Hong Quang
    College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea
    Bioorg Med Chem 19:2625-32. 2011
    ..Moreover, compounds 1, 2, 8, and 9 significantly inhibited the induction of COX-2 and iNOS mRNA dose-dependently, indicating that these compounds attenuated the synthesis of these transcripts at the transcriptional level...
  73. ncbi New 6-hydroxyeunicellins from a soft coral Cladiella sp
    Yung Husan Chen
    National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
    Chem Pharm Bull (Tokyo) 60:160-3. 2012
    ..Eunicellin 2 displayed inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils...
  74. ncbi Are pleuromutilin antibiotics finally fit for human use?
    Rodger Novak
    Nabriva Therapeutics AG, Vienna, Austria
    Ann N Y Acad Sci 1241:71-81. 2011
    ..This review will discuss key aspects of this antibacterial class and provide some insight into the question of why it took half a century to develop a systemic pleuromutilin for human use...
  75. pmc New Briarane diterpenoids from the gorgonian coral Junceella juncea
    Jiun Yang Chang
    School of Pharmacy, College of Medicine, National Taiwan University, Jen Ai Rd Sec 1, Taipei 101 200, Taiwan
    Mar Drugs 10:1321-30. 2012
    ..The anti-inflammatory activities tested on superoxide anion generation and elastase release by human neutrophils in response to FMLP/CB were evaluated...
  76. ncbi Proteomic investigation of anti-tumor activities exerted by sinularin against A2058 melanoma cells
    Tzu rong Su
    Antai Tian Sheng Memorial Hospital, Pingtung, Taiwan
    Electrophoresis 33:1139-52. 2012
    ..These data provide important information for the mechanisms of anti-tumor effects of sinularin on melanoma cells and may be helpful for drug development and progression monitoring of human melanoma...
  77. ncbi Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
    Mara B Antonoff
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Surgery 146:282-90. 2009
    ..Our objectives were to assess the effectiveness of triptolide, an Hsp-70 inhibitor, in treating neuroblastoma in vitro and in vivo, and to measure the associated effects on Hsp-70 levels and apoptosis markers...
  78. ncbi Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours
    J J E M Kitzen
    Dept of Medical Oncology, Erasmus University Medical Center, EA Rotterdam, The Netherlands
    Eur J Cancer 45:1764-72. 2009
    ..Pharmacokinetic studies showed high inter-individual variability and rendered F60008 a far from optimal derivate of triptolide...
  79. ncbi Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages
    Ting Shen
    School of Bioscience and Biotechnology, Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 200 701, Republic of Korea
    Biol Pharm Bull 33:128-32. 2010
    ..Therefore our data suggest that cafestol may be a novel ERK inhibitor with AP-1-targeted inhibitory activity against PGE(2) production in LPS-activated RAW264.7 cells...
  80. ncbi Prospective, randomized, double-blind study of safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC)
    Tony Y H Chen
    Centre Hospitalier Universitaire de Sherbrooke, Service d urologie 3001, Canada
    Int Urogynecol J Pelvic Floor Dysfunct 16:293-7. 2005
    ..To determine the safety and tolerability of intravesical resiniferatoxin (RTX) in interstitial cystitis (IC) patients...
  81. ncbi Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent
    Bimolendu Das
    Indian Institute of Chemical Biology CSIR, Kolkata, India
    Bioorg Med Chem Lett 20:6947-50. 2010
    ..The structures of the analogues were established through spectroscopic and analytical data...
  82. ncbi (5R)-5-hydroxytriptolide (LLDT-8), a novel triptolide analog mediates immunosuppressive effects in vitro and in vivo
    Ru Zhou
    Laboratory of Immunopharmacology, Graduate School of the Chinese Academy of Sciences, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China
    Int Immunopharmacol 5:1895-903. 2005
    ..The results suggested that LLDT-8 had immunosuppressive activities in both cellular and humoral immune responses. LLDT-8 might be a potential therapeutic agent for immune-related diseases...
  83. ncbi Diterpenes from the Hainan soft coral Lobophytum cristatum Tixier-Durivault
    Liang Li
    State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Zhangjiang Hi Tech Park, Shanghai 201203, People s Republic of China
    J Nat Prod 74:2089-94. 2011
    ..The present work supports Faulkner's proposal of prenylgermacrene as the precursor of many diterpenes. In a bioassay, lobophytumins C and D (3 and 4) showed weak in vitro cytotoxicities against the tumor cell lines ..
  84. pmc Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum
    Nai Lun Lee
    National Museum of Marine Biology and Aquarium, Pingtung, Taiwan
    Mar Drugs 9:2526-36. 2011
    ..Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines...
  85. ncbi Triptolide-induced cell cycle arrest and apoptosis in human renal cell carcinoma cells
    Jingjie Li
    Department of Pharmacology, Zhong Shan School of Medicine, Sun Yat Sen University, Guangzhou, PR China
    Oncol Rep 25:979-87. 2011
    ..Therefore, triptolide emerges as a stimulator of apoptosis by influencing coordinate regulation of proliferation and apoptosis, and may be applicable to the treatment of human renal cell carcinoma...
  86. ncbi Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia
    Shao Rui Chen
    Department of Anesthesiology, Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Brain Res 1042:108-13. 2005
    ..These data provide complementary new information that gabapentin administered systemically and spinally can effectively relieve tactile allodynia in this animal model of postherpetic neuralgia...
  87. ncbi Triptolide induces Bcl-2 cleavage and mitochondria dependent apoptosis in p53-deficient HL-60 cells
    Chi Keung Wan
    Department of Biology and Chemistry, Bioactive Products Research Group, City University of Hong Kong, Kowloon, Hong Kong SAR, China
    Cancer Lett 241:31-41. 2006
    ....
  88. doi Bipinnatins K-Q, minor cembrane-type diterpenes from the West Indian Gorgonian Pseudopterogorgia kallos: isolation, structure assignment, and evaluation of biological activities
    Jeffrey Marrero
    J Nat Prod 71:381-9. 2008
    ..However, only bipinnatin Q ( 6) displayed significant cytotoxic activity. Some of the compounds isolated proved to be inhibitors of acetylcholine receptors...
  89. ncbi Pachyclavulariolides M-R, six novel diterpenoids from a Taiwanese soft coral Pachyclavularia violacea
    Jyh Horng Sheu
    Department of Marine Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    J Nat Prod 66:662-6. 2003
    ..The structures and relative stereochemistry of compounds 1-6 were established by spectroscopic analyses. Compound 1 has been shown to exhibit significant cytotoxicity toward P-388 cancer cells. Biosynthesis of 4-6 is discussed...
  90. ncbi Inhibition by triptolide of chemokine, proinflammatory cytokine, and adhesion molecule expression induced by lipopolysaccharide in corneal fibroblasts
    Ying Lu
    Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi, Japan
    Invest Ophthalmol Vis Sci 47:3796-800. 2006
    ..The effects of triptolide on the expression of these proteins induced by lipopolysaccharide (LPS) in human corneal fibroblasts were examined in comparison with those of dexamethasone...
  91. ncbi Cytotoxic cembranoid diterpenes from a soft coral Sinularia gibberosa
    Guoqiang Li
    State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People s Republic of China
    J Nat Prod 68:649-52. 2005
    Five new alpha-methylene-gamma-lactone-bearing cembranoid diterpenes, sinularolides A-E (1-5), along with 10 known cembranoids, were isolated from the soft coral Sinularia gibberosa...
  92. ncbi Crassolides A-F, cembranoids with a trans-fused lactone from the soft coral Sarcophyton crassocaule
    Ho Cheng Huang
    Department of Marine Biotechnology and Resources, National Sun Yat Sen University, Kaohsiung 804, Taiwan, Republic of China
    J Nat Prod 69:1554-9. 2006
    ..The full assignment of NMR data of 7 is reported herein for the first time. The cytotoxicity of crassocolides 1-4, 6, and 7 against a limited panel of cancer cells was also determined...
  93. ncbi New furanoid diterpenes from Caesalpinia pulcherrima
    Consolacion Y Ragasa
    Chemistry Department, De La Salle University, 2401 Taft Avenue, Manila, 1004 Philippines
    J Nat Prod 65:1107-10. 2002
    ..Antimicrobial tests on 1-5 indicated that they were active against several bacteria (S. aureus, E. coli, P. aeruginosa, and B. subtilis) and fungi (C. albicans and T. mentagrophytes)...
  94. ncbi Heat shock protein upregulation protects against pacing-induced myolysis in HL-1 atrial myocytes and in human atrial fibrillation
    Bianca J J M Brundel
    Department of Radiation and Stress Cell Biology, Groningen University Institute for Drug Exploration GUIDE, University Medical Center of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Mol Cell Cardiol 41:555-62. 2006
    ..Pharmacological induction of Hsp, with drugs such as GGA, may represent a novel therapeutic approach in AF...
  95. ncbi Induction of heat shock response protects the heart against atrial fibrillation
    Bianca J J M Brundel
    Department of Medicine and Research Center, Montreal Heart Institute, 5000 Belanger St E, Montreal, Quebec H1T 1C8, Canada
    Circ Res 99:1394-402. 2006
    ..These findings advance our understanding of the biochemical determinants of AF and suggest the possibility that HSP induction may be an interesting novel approach to preventing clinical AF...
  96. ncbi Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling
    Xiao Dong Pan
    Department of Neurology, Union Hospital of Fujian Medical University, Fuzhou, Fujian, People s Republic of China
    Glia 57:1227-38. 2009
    ..Therefore, T4 may be an effective agent in modulating neuroinflammatory process in AD...
  97. ncbi In vitro alpha-glucosidase and alpha-amylase enzyme inhibitory effects of Andrographis paniculata extract and andrographolide
    Rammohan Subramanian
    Department of Pharmacology, School of Pharmacy, Universiti Sains Malaysia, Penang, Malaysia
    Acta Biochim Pol 55:391-8. 2008
    ..paniculata extract to exert antidiabetic activity and indicates that AP extract can be considered as a potential candidate for the management of type 2 diabetes mellitus...
  98. ncbi Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death
    Sandy D Westerheide
    Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, Illinois 60208, USA
    J Biol Chem 281:9616-22. 2006
    ..The ability of triptolide to inhibit the heat shock response renders these cells sensitive to stress-induced cell death, which may be of great relevance to cancer treatments...
  99. ncbi Triptolide sensitizes lung cancer cells to TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by inhibition of NF-kappaB activation
    Kye Young Lee
    Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea
    Exp Mol Med 34:462-8. 2002
    ..These observations suggest that triptolide may be a potentially useful drug to enhance TRAIL-induced tumor killing in lung cancer...
  100. ncbi HIV type 1 inhibition by protein kinase C modulatory compounds
    David Warrilow
    Division of Immunology and Infectious Disease, Queensland Institute of Medical Research, Brisbane, Queensland 4006, Australia
    AIDS Res Hum Retroviruses 22:854-64. 2006
    ..This result hints at the possibility of inhibition by a PKC modulatory compound of an early pathway of viral entry in PBMC...
  101. ncbi The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats
    John Winston
    Enteric Neuromuscular Disorders and Pain Laboratory, Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Texas Medical Branch, Galveston 77555 0764, USA
    Gastroenterology 132:615-27. 2007
    ....

Research Grants62

  1. SYNTHESIS OF EUNICELLIN DITERPENES AND RELATED COMPOUNDS
    MATTHIAS MCINTOSH; Fiscal Year: 2003
    ..The highly promising biological activities of these and other eunicellin diterpenes demands a concise yet general approach to synthesis of this class of molecules...
  2. New Methods for the Synthesis of Neurological Agents and Other Heterocyclic Molec
    Larry E Overman; Fiscal Year: 2013
    ..Macfarlandin E, norrlandin, and chromodorolide A are rearranged spongian diterpenes that contain the rare 4,6-diacetoxy-2,7-dioxabicyclo[3.2.1]octan-3-one ring system...
  3. Enzymatic formation of the hydrocarbon skeletons underlying diterpenoid diversity
    REUBEN JOHN PETERS; Fiscal Year: 2013
    ..Accordingly, our studies have implications not only for providing increased access to such natural products, but also insights into potential drug targets, specifically in the widespread pathogen M. tuberculosis. ..
  4. b-Lactones: Bioactive Target and Vehicles for Synthesis
    Daniel Romo; Fiscal Year: 2010
    ..4) We propose double- diastereoselective, bis-cyclizations for the synthesis of -lactone-fused tetrahydrofurans to access THFs found in the haterumalides(Hat)/biselides(Bise). ..
  5. Synthesis of Complex Terpenes
    Phil S Baran; Fiscal Year: 2013
    ....
  6. Biosynthesis of Taxol Precursors in Transgenic Moss
    Aldwin Anterola; Fiscal Year: 2009
    ..This process, however, is very expensive and do not provide a steady supply of the drug. The goal of this project is to develop an economical method of producing Taxol and Taxotere using moss bioreactors. ..
  7. Synthesis of the Biologically Active Ineleganolide and Related Norcembranoids
    Robert A Craig; Fiscal Year: 2013
    ..sponge Sinularia inelegans along with a variety of structurally related, biologically active norcembranoid diterpenes. Isolated initially using bioassay-guided fractionation, ineleganolide was proven to have cytotoxic effects ..
  8. MANGANESE (III) BASED OXIDATIVE FREE RADICAL CYCLIZATION
    BARRY SNIDER; Fiscal Year: 2000
    ..The antibiotic diterpenes cyathin B3, allocyathin B2 and the nerve growth factor production stimulant erinacine A will be prepared by ..
  9. Total Synthesis of Bicyclic Bioactive Diterpenoids
    Jon T Njardarson; Fiscal Year: 2013
    ..The new synthetic method proposed will benefit chemists both in academia and the pharmaceutical industry thus directly or indirectly impacting the discovery, study, development and production of new drugs. ..
  10. TOTAL SYNTHESIS OF BIOACTIVE NATURAL PRODUCTS
    JIN CHA; Fiscal Year: 2007
    ..for the next budget period are ingenol (la), as a prominent member of the ingenane, tigliane, and daphnane diterpenes [e.g...
  11. SYNTHESIS OF ANTILEUKEMIC & TUMOR-PROMOTING TERPENOIDS
    DAVID WIEMER; Fiscal Year: 1990
    ..Ultimately, this may lead to the ability to design second generation substances with enhanced antileukemic activity, and to a better understanding of the process of tumor promotion...
  12. NEW METHODOLOGY FOR THE SYNTHESIS OF ANTITUMOR AGENTS
    Jeffrey Winkler; Fiscal Year: 1992
    ..The constructions of the carbon skeleta of the ingenane and clerodane diterpenes, taxusin, mesembrine, and the vinca alkaloids outlined in this proposal attest to the considerable potential for ..
  13. TOTAL SYNTHESIS OF CLERODANE DITERPENES
    Michael Taschner; Fiscal Year: 1990
    ..It is hoped this can be extended to ultimately control the stereochemistry at five contiguous asymmetric centers not only in a relative sense but also in an absolute sense as well...
  14. Total Synthesis by Asymmetric Catalytic Methods
    Eric Jacobsen; Fiscal Year: 2007
    ..abstract_text> ..
  15. SYNTHESIS AND STUDY OF TUMOR PROMOTERS & INHIBITORS
    Daniel Harvey; Fiscal Year: 1993
    ..of this methodology to the construction of the basic tricyclic ring skeleton of the tigliane and daphnane diterpenes. Members of these classes of compounds have been widely studied, primarily because of their ability to promote ..
  16. Asymmetric Total Synthesis of Cyanthiwigin AC
    GLENN SAMMIS; Fiscal Year: 2005
    ..The stereo selective and convergent route will provide an efficient synthesis of cyanthiwigin AC as well as access to potentially bioactive synthetic analogs. ..
  17. New Cycloadditions in Synthesis
    MARC SNAPPER; Fiscal Year: 2006
    ..Concise applications of the chemistry toward the synthesis of diterpenes, such as kalmanol, are detailed...
  18. STEREOCONTROLLED [M+N] ANNULATION REACTIONS
    GARY MOLANDER; Fiscal Year: 2000
    ..Included are approaches to the eunicellin/cladiellin/asbestinin class of diterpenes, which possess particular importance in health related fields...
  19. UNIVERSITY MASS SPECTROMETER RESOURCE ACQUISITION
    John Falck; Fiscal Year: 1990
    ..A wide carbohydrates, antibodies, polycyclic aromatics, prostaglandins, leukotrienes are related oxygenated fatty acid metabolites, diterpenes, stable isotope labeled standards, cyclitols, oligopeptides, drugs and other xenobiotics.
  20. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  21. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  22. TUMOR REMISSION--TAXOL AND CLOSE ANALOGS VIA SYNTHESIS
    LEO PAQUETTE; Fiscal Year: 2003
    ..These include, but are not limited to, the 1-deoxy, D-homo-, 2-desmethyl, and 12-methylene derivatives, in addition to the D-ring invertomer and the C-nor isomer. ..
  23. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  24. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  25. SYNTHESIS OF THE TEDANOLIDES, CYTOTOXIC POLYPROPIONATES
    Michael Jung; Fiscal Year: 2003
    ....
  26. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  27. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  28. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  29. ASYMMETRIC SYNTHESIS OF ANTITUMOR AGENTS
    MICHAEL CRIMMINS; Fiscal Year: 2005
    ..Laulimalide stimulates tubulin polymerization more effectively than paclitaxel. Laulimalide is a representative of a new class of microtubule stabilizing agents with promise for therapeutic potential. ..
  30. ASYMMETRIC SYNTHESIS OF NOVEL NATURAL PRODUCTS
    MICHAEL CRIMMINS; Fiscal Year: 2006
    ..Synthesis of the biologically active agents guanacastepene, and SCH 351448 will also be pursued. ..
  31. SYNTHETIC STUDIES RELATED TO CANCER RESEARCH/TREATMENT
    Paul Wender; Fiscal Year: 2005
    ..Overall, this research program is expected to be of significant value in chemistry, biology, and medicine. ..
  32. Micromass LCT Mass Spectrometer
    MICHAEL CRIMMINS; Fiscal Year: 2004
    ..The major users group is highly dependent on rapid turn around mass spectral data. Since there is currently no Departmental mass spectrometry facility, the research programs of the major users have been seriously hampered for some time. ..
  33. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  34. Molecular Target Focused Discovery of Anticancer Drugs
    GEORGE PETTIT; Fiscal Year: 2007
    ..In summary, the proposed research will be sharply aimed at the discovery and very rapid development of new anticancer drugs for the NCI programs direct at improving human cancer treatments. ..
  35. Cellular Regulation of Salt Taste Transduction
    Vijay Lyall; Fiscal Year: 2008
    ..The identification of natural and synthetic analogues similar to cetylpyridinium chloride that modulate the non-specific cation receptor channel may be potentially useful as salt taste enhancers or suppressers. ..
  36. Synthesis of Macrolides, Steroids, Cyclopentanoids, etc.
    BARRY TROST; Fiscal Year: 2009
    ..These new synthetic methods apply to many structural types beyond those illustrated and constitutes a significant to gain access to complex molecular targets more easily. ..
  37. CHEMICAL SYNTHESIS OF NOVEL NATURAL PRODUCTS
    David Williams; Fiscal Year: 2009
    ..Daphnicyclidin A. This recent discovery has revealed a new molecular architecture which exhibits significant antitumor activity. Our research will investigate strategies for chemical synthesis of these complex polycyclic systems. ..
  38. A Modular Approach for Combinatorial Biosynthesis of Functionalized Terpenoids
    REUBEN JOHN PETERS; Fiscal Year: 2010
    ..Bacterial production will provide an effective source for production of the larger amounts of these natural products necessary for detailed investigation of their promising biological activity. ..
  39. Inhibitors of Hedgehog Signaling For Brain Cancer Chemotherapy
    JEFFREY D contact WINKLER; Fiscal Year: 2010
    ..The studies outlined herein therefore hold the promise of developing important new tools in cancer biology and new drug candidates for the treatment of brain cancers. ..
  40. Molecular Target Focused Discovery of Anticancer Drugs
    George R Pettit; Fiscal Year: 2010
    ....
  41. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..
  42. kappa-agonist effects of the hallucinogen Salvinorin A
    Eduardo Butelman; Fiscal Year: 2008
    ....
  43. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  44. EFFECTS OF SYSTEMICALLY ADMINISTERED DYNORPHINS
    Eduardo Butelman; Fiscal Year: 2002
    ....
  45. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003
    ..abstract_text> ..
  46. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  47. Molecular Targeting of the Vanilloid-1 Receptor
    JOHN NEUBERT; Fiscal Year: 2006
    ..These outcomes are expected to have significant positive effects on a wide spectrum of pain relating to tissue damage and injury. [unreadable] [unreadable]..
  48. INTERESTING BIOACTIVE SUBSTANCES
    David Williams; Fiscal Year: 2006
    ..The selective synthesis of contiguous stereotriads will advance basic methodology for asymmetric conjugate additions. ..
  49. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..abstract_text> ..
  50. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  51. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes [unreadable] [unreadable]..
  52. AMINO ACID CONJUGATION OF BILE ACIDS
    Stephen Barnes; Fiscal Year: 2006
    ..abstract_text> ..
  53. ANALOGUES OF METHYLLYCACONITINE
    STEPHEN BERGMEIER; Fiscal Year: 2004
    ..Further we have shown that several of these compounds are among the most potent nicotinic antagonists known. We have also shown that the potency of these compounds can be improved through simple modifications. ..
  54. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  55. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    This research program focuses on developing novel and efficient syntheses of two structurally distinct classes of diterpenes employing related tactics and strategies...
  56. Center for Nutrient-Gene Interaction in Cancer Preventi*
    Stephen Barnes; Fiscal Year: 2008
    ..In addition to the main projects, the Center will organize a competitive Pilot Project/Developmental program for the evaluation of new ideas and methods pertinent to the overall development of the Center. ..
  57. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  58. Pathophysiology of Arginine-induced Pancreatitis in Mice
    Ashok Saluja; Fiscal Year: 2006
    ..Successful completion of these studies will provide an excellent model of pancreatitis for future studies dealing with therapeutic interventions. ..
  59. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..