cannabinoids

Summary

Summary: Compounds having the cannabinoid structure. They were originally extracted from Cannabis sativa L. The most pharmacologically active constituents are TETRAHYDROCANNABINOL; CANNABINOL; and CANNABIDIOL.

Top Publications

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
  2. ncbi The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice
    Eva Mikics
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 17:223-30. 2006
  3. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
  4. ncbi Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    L A Matsuda
    Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Maryland 20892
    Nature 346:561-4. 1990
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
  6. ncbi Role of endogenous cannabinoids in synaptic signaling
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u 43, H 1083 Hungary
    Physiol Rev 83:1017-66. 2003
  7. ncbi Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
  8. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
  9. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
  10. pmc International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Pharmacol Rev 62:588-631. 2010

Detail Information

Publications342 found, 100 shown here

  1. ncbi Molecular characterization of a peripheral receptor for cannabinoids
    S Munro
    MRC Laboratory of Molecular Biology, Cambridge, UK
    Nature 365:61-5. 1993
    ..The clinical application of cannabinoids has, however, been limited by their psychoactive effects, and this has led to interest in the biochemical bases ..
  2. ncbi The effects of cannabinoids on contextual conditioned fear in CB1 knockout and CD1 mice
    Eva Mikics
    Institute of Experimental Medicine, Budapest, Hungary
    Behav Pharmacol 17:223-30. 2006
    We studied the effects of cannabinoids on contextual conditioned fear responses. CB1 knockout and wild-type (CD1) mice were exposed to a brief session of electric shocks, and their behavior was studied in the same context 24 h later...
  3. pmc Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation
    Alexander F Hoffman
    United States Department of Health and Human Services, National Institutes of Health, National Institute on Drug Abuse, Intramural Research Program, Cellular Neurobiology Branch, Electrophysiology Research Unit, Baltimore, Maryland 21224, USA
    Learn Mem 14:63-74. 2007
    ..Although cannabinoids acutely reduce glutamate release and block hippocampal long-term potentiation (LTP), a potential substrate for ..
  4. ncbi Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    L A Matsuda
    Laboratory of Cell Biology, National Institutes of Mental Health, Bethesda, Maryland 20892
    Nature 346:561-4. 1990
    Marijuana and many of its constituent cannabinoids influence the central nervous system (CNS) in a complex and dose-dependent manner...
  5. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  6. ncbi Role of endogenous cannabinoids in synaptic signaling
    Tamas F Freund
    Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest 8, Szigony u 43, H 1083 Hungary
    Physiol Rev 83:1017-66. 2003
    ..In addition, the behavioral effects of exogenous cannabinoids such as delta-9-tetrahydrocannabinol, the major active compound of hashish and marijuana, await explanation at ..
  7. ncbi Identification and functional characterization of brainstem cannabinoid CB2 receptors
    Marja D Van Sickle
    Institute of Infection, Immunity, and Inflammation and Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada T2N 4N1
    Science 310:329-32. 2005
    ..CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas...
  8. pmc The orphan receptor GPR55 is a novel cannabinoid receptor
    E Ryberg
    Department of Lead Generation, AstraZeneca R and D, Molndal, Sweden
    Br J Pharmacol 152:1092-101. 2007
    ..Work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in a number of physiological processes...
  9. pmc Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
    Maria Salazar
    Department of Biochemistry and Molecular Biology, Complutense University, Madrid, Spain
    J Clin Invest 119:1359-72. 2009
    ..human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo...
  10. pmc International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CB₂
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Pharmacol Rev 62:588-631. 2010
    ....
  11. ncbi Towards the use of cannabinoids as antitumour agents
    Guillermo Velasco
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, and the Instituto Universitario de Investigación Neuroquímica IUIN, Madrid 28040, Spain
    Nat Rev Cancer 12:436-44. 2012
    Various reports have shown that cannabinoids (the active components of marijuana and their derivatives) can reduce tumour growth and progression in animal models of cancer, in addition to their well-known palliative effects on some cancer-..
  12. ncbi Chronic pubertal, but not adult chronic cannabinoid treatment impairs sensorimotor gating, recognition memory, and the performance in a progressive ratio task in adult rats
    Miriam Schneider
    Brain Research Institute, Department of Neuropharmacology, University of Bremen, Bremen, Germany
    Neuropsychopharmacology 28:1760-9. 2003
    ..The present study tested the hypothesis that long-lasting interference of cannabinoids with the developing endogenous cannabinoid system during puberty causes persistent behavioral alterations in ..
  13. ncbi Cannabinoids induce glioma stem-like cell differentiation and inhibit gliomagenesis
    Tania Aguado
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    J Biol Chem 282:6854-62. 2007
    ..b>Cannabinoids are known to exert an antitumoral action on gliomas that relies on at least two mechanisms: induction of ..
  14. pmc Brain monoglyceride lipase participating in endocannabinoid inactivation
    T P Dinh
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    Proc Natl Acad Sci U S A 99:10819-24. 2002
    The endogenous cannabinoids (endocannabinoids) are lipid molecules that may mediate retrograde signaling at central synapses and other forms of short-range neuronal communication...
  15. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    ..These findings indicate that the function of endogenous cannabinoids released by depolarized hippocampal neurons might be to downregulate GABA release...
  16. ncbi Inhibition of nitric oxide production in RAW264.7 macrophages by cannabinoids and palmitoylethanolamide
    R A Ross
    Department of Biomedical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, AB25 2ZD, Scotland, Aberdeen, UK
    Eur J Pharmacol 401:121-30. 2000
    ..7 macrophages by the cannabinoids and the putative cannabinoid CB(2)-like receptor ligand, palmitoylethanolamide...
  17. ncbi The schizophrenia susceptibility gene neuregulin 1 modulates tolerance to the effects of cannabinoids
    Aurelie A Boucher
    Department of Pharmacology, Bosch Institute, University of Sydney, Australia
    Int J Neuropsychopharmacol 14:631-43. 2011
    ..show that the schizophrenia susceptibility gene neuregulin 1 (Nrg1) modulates the development of tolerance to cannabinoids in mice...
  18. ncbi Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
    A C Kreitzer
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 29:717-27. 2001
    ..These findings suggest that Purkinje cells release endogenous cannabinoids in response to elevated calcium, thereby inhibiting presynaptic calcium entry and suppressing transmitter ..
  19. ncbi Cannabinoid activation of peroxisome proliferator-activated receptors: potential for modulation of inflammatory disease
    S E O'Sullivan
    School of Graduate Entry Medicine and Health, University of Nottingham, Nottingham, UK
    Immunobiology 215:611-6. 2010
    b>Cannabinoids act via cell surface G protein-coupled receptors (CB(1) and CB(2)) and the ion channel receptor TRPV1...
  20. pmc Regression of fibrosis after chronic stimulation of cannabinoid CB2 receptor in cirrhotic rats
    Javier Muñoz-Luque
    Servicio de Bioquímica y Genética Molecular, Hospital Clinic Universitari, Villarroel 170, Barcelona 08036, Spain
    J Pharmacol Exp Ther 324:475-83. 2008
    ....
  21. pmc Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects
    Wen Jiang
    Neuropsychiatry Research Unit, Department of Psychiatry, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Clin Invest 115:3104-16. 2005
    ..of abuse examined to date decrease adult hippocampal neurogenesis, but the effects of cannabis (marijuana or cannabinoids) on hippocampal neurogenesis remain unknown...
  22. ncbi Modulation of anxiety through blockade of anandamide hydrolysis
    Satish Kathuria
    Department of Pharmacology, University of California, Irvine, California, USA
    Nat Med 9:76-81. 2003
    ..produces in humans subjective responses mediated by CB1 cannabinoid receptors, indicating that endogenous cannabinoids may contribute to the control of emotion...
  23. ncbi Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Trends Pharmacol Sci 30:515-27. 2009
    ..However, the plant Cannabis contains many cannabinoids with weak or no psychoactivity that, therapeutically, might be more promising than Delta(9)-..
  24. ncbi Endocannabinoid signaling in the brain
    Rachel I Wilson
    Division of Biology, 139 74, California Institute of Technology, Pasadena, CA 91125, USA
    Science 296:678-82. 2002
    ..In contrast to classical neurotransmitters, endogenous cannabinoids can function as retrograde synaptic messengers: They are released from postsynaptic neurons and travel backward ..
  25. ncbi Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    J A Wagner
    Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond, VA 23298, USA
    Eur J Pharmacol 423:203-10. 2001
    ..Using the radioactive microsphere technique, we examined the effects of cannabinoids on systemic hemodynamics in anesthetized rats...
  26. ncbi Cannabinoid signalling
    Dirk G Demuth
    School of Life Sciences, University of Hertfordshire, CP Snow Building, Hatfield, Herts, UK
    Life Sci 78:549-63. 2006
    ..receptors, CB(1) and CB(2), have been the focus of research into the cellular signalling mechanisms of cannabinoids. The initial assessment, mainly derived from expression studies, was that cannabinoids, via G(i/o) proteins, ..
  27. ncbi Cannabinoids and anxiety
    Fabricio A Moreira
    Department of Pharmacology, Federal University of Minas Gerais, Av Antonio Carlos 6627, Belo Horizonte, MG 31270 901, Brazil
    Curr Top Behav Neurosci 2:429-50. 2010
    The term cannabinoids encompasses compounds produced by the plant Cannabis sativa, such as delta9-tetrahydrocannabinol, and synthetic counterparts. Their actions occur mainly through activation of cannabinoid type 1 (CB1) receptors...
  28. ncbi Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation
    Belén G Ramirez
    Neurodegeneration Group, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 25:1904-13. 2005
    ..b>Cannabinoids are neuroprotective agents against excitotoxicity in vitro and acute brain damage in vivo...
  29. pmc Cannabinoid and cannabinoid-like receptors in microglia, astrocytes, and astrocytomas
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98195 7280, USA
    Glia 58:1017-30. 2010
    ....
  30. pmc Cannabinoids as pharmacotherapies for neuropathic pain: from the bench to the bedside
    Elizabeth J Rahn
    Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, Georgia 30602, USA
    Neurotherapeutics 6:713-37. 2009
    ..b>Cannabinoids, drugs that share the same target as Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the psychoactive ingredient ..
  31. ncbi Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex
    Francis Rodriguez Bambico
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, Montreal, Quebec, Canada H3A 1A1
    J Neurosci 27:11700-11. 2007
    ..cannabis modulates mood and possesses antidepressant-like properties, mediated by the agonistic activity of cannabinoids on central CB1 receptors (CB1Rs)...
  32. ncbi Potency trends of Δ9-THC and other cannabinoids in confiscated cannabis preparations from 1993 to 2008
    Zlatko Mehmedic
    National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    J Forensic Sci 55:1209-17. 2010
    ..0-29.3% (2004-2008). Hash oil potencies also varied considerably during this period (16.8 ± 16.3%). The increase in cannabis preparation potency is mainly due to the increase in the potency of nondomestic versus domestic samples...
  33. ncbi Cannabinoids Potentiate Emotional Learning Plasticity in Neurons of the Medial Prefrontal Cortex through Basolateral Amygdala Inputs
    Steven R Laviolette
    Departments of Neuroscience, Psychiatry, and Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 26:6458-68. 2006
    b>Cannabinoids represent one of the most commonly used hallucinogenic drug classes...
  34. ncbi Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret
    K A Sharkey
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Eur J Neurosci 25:2773-82. 2007
    ....
  35. ncbi Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
    Stefan Hart
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    Cancer Res 64:1943-50. 2004
    b>Cannabinoids, the active components of marijuana and their endogenous counterparts were reported as useful analgetic agents to accompany primary cancer treatment by preventing nausea, vomiting, and pain and by stimulating appetite...
  36. ncbi The acute effects of cannabinoids on memory in humans: a review
    Mohini Ranganathan
    Schizophrenia Biological Research Center, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 188:425-44. 2006
    Cannabis is one of the most frequently used substances. Cannabis and its constituent cannabinoids are known to impair several aspects of cognitive function, with the most robust effects on short-term episodic and working memory in humans...
  37. ncbi Cannabinoid-based drugs as anti-inflammatory therapeutics
    Thomas W Klein
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Nat Rev Immunol 5:400-11. 2005
    ..as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive ..
  38. ncbi The endocannabinoid system: emotion, learning and addiction
    Fabricio A Moreira
    Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 6, 55099 Mainz, Germany
    Addict Biol 13:196-212. 2008
    ..However, the emotional responses to cannabinoids are not always pleasant and delightful...
  39. ncbi Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    Eduardo Molina-Holgado
    Department of Neural Plasticity, Cajal Institute, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 22:9742-53. 2002
    b>Cannabinoids exert pleiotropic actions in the CNS, including the inhibition of inflammatory responses and the enhancement of neuronal survival after injury...
  40. ncbi CB2 cannabinoid receptor-mediated peripheral antinociception
    T P Malan
    Department of Anesthesiology and Pharmacology, University of Arizona, Tucson, AZ 85724, USA
    Pain 93:239-45. 2001
    ..Peripheral antinociception without CNS effects is consistent with the peripheral distribution of CB(2) receptors. CB(2) receptor agonists may have promise clinically for the treatment of pain without CNS cannabinoid side effects...
  41. ncbi Cannabinoids and Parkinson's disease
    Moisés García-Arencibia
    Departamento de Bioquímica y Biología Molecular and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Complutense, 28040 Madrid, Spain
    CNS Neurol Disord Drug Targets 8:432-9. 2009
    ....
  42. pmc Cannabinoids excite circadian clock neurons
    Claudio Acuna-Goycolea
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Neurosci 30:10061-6. 2010
    b>Cannabinoids, the primary active agent in drugs of abuse such as marijuana and hashish, tend to generate a distorted sense of time...
  43. pmc Cannabinoids and cancer: pros and cons of an antitumour strategy
    Maurizio Bifulco
    Dipartimento di Scienze Farmaceutiche, Universita degli Studi di Salerno, Via Ponte Don Melillo, Fisciano 84084, Salerno, Italy
    Br J Pharmacol 148:123-35. 2006
    In the last two decades, research has dramatically increased the knowledge of cannabinoids biology and pharmacology...
  44. ncbi Regulation of cannabinoid CB1 receptors in the central nervous system by chronic cannabinoids
    Laura J Sim-Selley
    Department of Pharmacology and Toxicology, Institute for Drug and Alcohol Studies, Virginia Commonwealth University Medical College of Virginia, Richmond, Virginia 23298, USA
    Crit Rev Neurobiol 15:91-119. 2003
    ..However, tolerance and dependence to cannabinoids develops after chronic use, as demonstrated both clinically and in animal models...
  45. ncbi Cannabinoids prevent lipopolysaccharide-induced neurodegeneration in the rat substantia nigra in vivo through inhibition of microglial activation and NADPH oxidase
    Eun Sook Chung
    Department of Biochemistry and Molecular Biology, School of Medicine Kyung Hee University, Seoul 130 701, Korea
    Brain Res 1451:110-6. 2012
    We investigated the effects of synthetic cannabinoids, WIN55,212-2 and HU210, on LPS-injected rat substantia nigra in vivo...
  46. pmc Cannabinoids inhibit energetic metabolism and induce AMPK-dependent autophagy in pancreatic cancer cells
    I Dando
    Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy
    Cell Death Dis 4:e664. 2013
    The anti-tumoral effects of cannabinoids have been described in different tumor systems, including pancreatic adenocarcinoma, but their mechanism of action remains unclear...
  47. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012
    ..Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states...
  48. pmc Cannabinoids, endocannabinoids, and cancer
    Daniel J Hermanson
    AB Hancock Jr Memorial Laboratory for Cancer Research, Departments of Biochemistry, Vanderbilt Institute of Chemical Biology, Center in Molecular Toxicology, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Cancer Metastasis Rev 30:599-612. 2011
    ..The antiproliferative and apoptotic effects produced by some of these pharmacological probes reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer...
  49. ncbi Phytocannabinoids as novel therapeutic agents in CNS disorders
    Andrew J Hill
    School of Pharmacy, University of Reading, Whiteknights, Reading, RG6 6UB, United Kingdom
    Pharmacol Ther 133:79-97. 2012
    ..Here, we review pCB effects in preclinical models of CNS disease and, where available, clinical trial data that support therapeutic effects. Such developments may soon yield the first non-Δ(9)-THC pCB-based medicines...
  50. pmc The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques
    Fabrizio Montecucco
    Division of Cardiology, Faculty of Medicine, Foundation for Medical Researches, Geneva University Hospitals, Avenue de la Roseraie 64, 1211 Geneva 4, Switzerland
    Eur Heart J 33:846-56. 2012
    ..Here, we investigated the expression of the endocannabinoid system in human carotid plaques and the impact of CB(2) pharmacological activation on markers of plaque vulnerability in vivo and in vitro...
  51. pmc Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy
    Partha Mukhopadhyay
    Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 48:457-67. 2010
    ....
  52. ncbi Cannabinoids inhibit peptidoglycan-induced phosphorylation of NF-κB and cell growth in U87MG human malignant glioma cells
    Ryosuke Echigo
    Department of Impairment Study, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    Oncol Rep 28:1176-80. 2012
    ..b>Cannabinoids have been reported to exert anti-inflammatory and antitumor effects...
  53. ncbi Cannabinoids for cancer treatment: progress and promise
    Sami Sarfaraz
    Chemoprevention Program, Paul P Carbone Comprehensive Cancer Center and Department of Dermatology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin 53706, USA
    Cancer Res 68:339-42. 2008
    b>Cannabinoids are a class of pharmacologic compounds that offer potential applications as antitumor drugs, based on the ability of some members of this class to limit inflammation, cell proliferation, and cell survival...
  54. ncbi Cannabinoid-induced immune suppression and modulation of antigen-presenting cells
    Thomas W Klein
    Department of Medical Microbiology and Immunology, University of South Florida College of Medicine, MDC Box 10, 12901 Bruce Downs Boulevard, Tampa, FL 33612, USA
    J Neuroimmune Pharmacol 1:50-64. 2006
    ..current information on cannabinoid ligand and receptor biology, mechanisms involved in immune suppression by cannabinoids with emphasis on antigen-presenting cells, and preclinical and clinical models analyzing the therapeutic ..
  55. ncbi Leptin-regulated endocannabinoids are involved in maintaining food intake
    V Di Marzo
    Endocannabinoid Research Group, Istituto per la Chimica di Molecole di Interesse Biologico, CNR, 80072, Arco Felice, Naples, Italy
    Nature 410:822-5. 2001
    ..These findings indicate that endocannabinoids in the hypothalamus may tonically activate CB1 receptors to maintain food intake and form part of the neural circuitry regulated by leptin...
  56. pmc The impact of cannabis use on cognitive functioning in patients with schizophrenia: a meta-analysis of existing findings and new data in a first-episode sample
    Murat Yucel
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, National Neuroscience Facility, Alan Gilbert Building, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Schizophr Bull 38:316-30. 2012
    ....
  57. pmc The endocannabinoid system and cancer: therapeutic implication
    Josee Guindon
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Br J Pharmacol 163:1447-63. 2011
    ..inhibition of cell proliferation and migration, induction of apoptosis, reduction of tumour growth) of the cannabinoids in different types of cancer...
  58. ncbi The multiplicity of action of cannabinoids: implications for treating neurodegeneration
    Aoife Gowran
    Department of Physiology, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland
    CNS Neurosci Ther 17:637-44. 2011
    ..This article will discuss the experimental and clinical evidence supporting a potential role for CB-based therapies in the treatment of certain neurological diseases that feature a neurodegenerative component...
  59. ncbi A role for the putative cannabinoid receptor GPR55 in the islets of Langerhans
    Silvana Y Romero-Zerbo
    Fundacion IMABIS, Hospital Carlos Haya de Malaga, Laboratorio de Medicina Regenerativa, Pabellón de Gobierno, Sotano, Malaga, Spain
    J Endocrinol 211:177-85. 2011
    ..In this context, it may also represent a new target for consideration in the management of type 2 diabetes and related diseases...
  60. ncbi Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
    Yannick Marchalant
    Department of Psychology, The Ohio State University, Columbus, 43210, USA
    Neurobiol Dis 34:300-7. 2009
    ..Our results provide insight into the role of the endocannabinoid and vanilloid systems upon two different and detrimental aspects of normal and pathological aging, chronic neuroinflammation and decline in neurogenesis...
  61. ncbi Comparison of ELISAs for opiates, methamphetamine, cocaine metabolite, benzodiazepines, phencyclidine, and cannabinoids in whole blood and urine
    S Kerrigan
    California Department of Justice, Bureau of Forensic Services, Toxicology Laboratory, 4949 Broadway, Sacramento, CA 95820, USA
    Clin Chem 47:540-7. 2001
    ..ELISAs are widely utilized in forensic drug analysis. A comparative assessment of microtiter plate assays for the detection of six common classes of drug in blood and urine is described...
  62. pmc Cannabinoids suppress synaptic input to neurones of the rat dorsal motor nucleus of the vagus nerve
    Andrei V Derbenev
    Department of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA
    J Physiol 559:923-38. 2004
    b>Cannabinoids bind central type 1 receptors (CB1R) and modify autonomic functions, including feeding and anti-emetic behaviours, when administered peripherally or into the dorsal vagal complex...
  63. pmc Cannabinoids prevent the development of behavioral and endocrine alterations in a rat model of intense stress
    Eti Ganon-Elazar
    Department of Psychology, University of Haifa, Haifa, Israel
    Neuropsychopharmacology 37:456-66. 2012
    b>Cannabinoids have recently emerged as a possible treatment of stress- and anxiety-related disorders such as post-traumatic stress disorder (PTSD)...
  64. ncbi The cannabinoid system and immune modulation
    Thomas W Klein
    University of South Florida, College of Medicine, Department of Medical Microbiology and Immunology, Tampa 33612, USA
    J Leukoc Biol 74:486-96. 2003
    ..In addition, cannabinoids have been shown to modulate a variety of immune cell functions in humans and animals and more recently, have ..
  65. ncbi Chronic exposure to cannabinoids during adolescence but not during adulthood impairs emotional behaviour and monoaminergic neurotransmission
    Francis Rodriguez Bambico
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University, 1033 Pine Avenue West, Montreal, Canada H3A1A1
    Neurobiol Dis 37:641-55. 2010
    ..These suggest that long-term exposure to cannabinoids during adolescence induces anxiety-like and depression-like behaviours in adulthood and that this may be ..
  66. ncbi Early-onset cannabis use and cognitive deficits: what is the nature of the association?
    Harrison G Pope
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Drug Alcohol Depend 69:303-10. 2003
    ..Individuals who initiate cannabis use at an early age, when the brain is still developing, might be more vulnerable to lasting neuropsychological deficits than individuals who begin use later in life...
  67. ncbi Role of cannabinoids in multiple sclerosis
    John P Zajicek
    Clinical Neurology Research Group, Peninsula College of Medicine and Dentistry, Plymouth, UK
    CNS Drugs 25:187-201. 2011
    ..that our understanding of cannabinoid physiology and the provision of evidence for therapeutic benefit of cannabinoids has begun to accumulate...
  68. ncbi Cannabinoid signaling in glial cells
    Nephi Stella
    Department of Pharmacology, Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98195 7280, USA
    Glia 48:267-77. 2004
    ..use the cannabinoid signaling system to communicate with neighboring cells, and argues that nonpsychotropic cannabinoids, both marijuana-derived and synthetic, likely constitute lead compounds for therapy aimed at reducing acute and ..
  69. ncbi Evidence for novel cannabinoid receptors
    Malcolm Begg
    National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, 5625 Fishers Lane, MSC 9413 Bethesda, MD 8092 9413, United States
    Pharmacol Ther 106:133-45. 2005
    b>Cannabinoids, including the bioactive constituents of the marijuana plant, their synthetic analogs, and endogenous lipids with cannabinoid-like activity, produce their biological effects by interacting with specific receptors...
  70. ncbi Cannabinoids reveal importance of spike timing coordination in hippocampal function
    David Robbe
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    Nat Neurosci 9:1526-33. 2006
    b>Cannabinoids impair hippocampus-dependent memory in both humans and animals, but the network mechanisms responsible for this effect are unknown...
  71. ncbi Ontogenetic development of cannabinoid receptor expression and signal transduction functionality in the human brain
    Susana Mato
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Cantabria, Santander, Spain
    Eur J Neurosci 17:1747-54. 2003
    ....
  72. ncbi Short- and long-term effects of cannabinoids on the extinction of contextual fear memory in rats
    Fabrício A Pamplona
    Departamento de Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Santa Catarina, Campus Universitario Trindade, 88049 900 Florianopolis, SC, Brazil
    Neurobiol Learn Mem 90:290-3. 2008
    ..The present results confirm and extend previous findings showing that the eCB system modulates short-term fear memory extinction with long-lasting consequences...
  73. ncbi Cannabinoids inhibit striatonigral GABAergic neurotransmission in the mouse
    I Wallmichrath
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, Albertstrasse 25, D 79104, Freiburg i Br, Germany
    Neuroscience 113:671-82. 2002
    ..Endocannabinoids released from SNR neurons can modulate striatonigral neurotransmission by inhibiting GABA release from terminals of striatonigral axons...
  74. pmc The endocannabinoid system as a target for the treatment of motor dysfunction
    Javier Fernandez-Ruiz
    Departamento de Bioquímica y Biología Molecular and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Br J Pharmacol 156:1029-40. 2009
    ..in PD], but also the delay of disease progression due to the neuroprotective properties demonstrated for cannabinoids (e.g...
  75. pmc In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
    B B Yao
    Neuroscience Disease Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Br J Pharmacol 149:145-54. 2006
    ..Based on its in vivo analgesic efficacy, AM1241 has been classified as a CB2-selective agonist. However, in vitro characterization of AM1241 in functional assays has not been reported...
  76. ncbi Long-term consequences of adolescent cannabis exposure on the development of cognition, brain structure and function: an overview of animal and human research
    Gerry Jager
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, The Netherlands
    Curr Drug Abuse Rev 1:114-23. 2008
    ....
  77. ncbi Developmental exposure to cannabinoids causes subtle and enduring neurofunctional alterations
    Patrizia Campolongo
    Department of Physiology and Pharmacology Vittorio Erspamer, Sapienza University of Rome, P le A Moro 5, 00185 Rome, Italy
    Int Rev Neurobiol 85:117-33. 2009
    ..they are often considered relatively harmless, increasing evidence suggests that developmental exposure to cannabinoids induces subtle neurofunctional alterations in the offspring...
  78. ncbi Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment
    Sasidhar Murikinati
    Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany
    FASEB J 24:788-98. 2010
    ..Jüttler, E., Keinert, T., Ridder, D. A., Muhammad, S., Waibler, Z., Ledent, C., Zimmer, A., Kalinke, U., Schwaninger, M. Activation of cannabinoid 2 receptors protects against cerebral ischemia by inhibiting neutrophil recruitment...
  79. pmc R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids
    Philipp Bishay
    Pharmazentrum frankfurt ZAFES, Clinical Pharmacology, Goethe University, Frankfurt, Germany
    PLoS ONE 5:e10628. 2010
    ..R-flurbiprofen, one of the enantiomers of flurbiprofen racemate, is inactive with respect to cyclooxygenase inhibition, but shows analgesic properties without relevant toxicity. Its mode of action is still unclear...
  80. pmc Antiaversive effects of cannabinoids: is the periaqueductal gray involved?
    F A Moreira
    Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Avenida Bandeirantes 3900, 14049900 Ribeirão Preto, SP, Brazil
    Neural Plast 2009:625469. 2009
    b>Cannabinoids play an important role in activity-dependent changes in synaptic activity and can interfere in several brain functions, including responses to aversive stimuli...
  81. pmc Species differences in cannabinoid receptor 2 (CNR2 gene): identification of novel human and rodent CB2 isoforms, differential tissue expression and regulation by cannabinoid receptor ligands
    Q R Liu
    Mol Neurobiol Branch, NIDA IRP, NIH, Baltimore, MD, USA
    Genes Brain Behav 8:519-30. 2009
    b>Cannabinoids, endocannabinoids and marijuana activate two well-characterized cannabinoid receptors (CB-Rs), CB1-Rs and CB2-Rs...
  82. pmc Role of cannabinoids in the development of fatty liver (steatosis)
    Vishnudutt Purohit
    Chemistry and Physiological Systems Research Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse NIDA, National Institutes of Health, Bethesda, Maryland 20892 9555, USA
    AAPS J 12:233-7. 2010
    Emerging evidence suggests that cannabinoids play an important role in the modulation of fatty liver, which appears to be mediated via activation of cannabinoid receptors...
  83. ncbi Bidirectional cannabinoid modulation of social behavior in adolescent rats
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Psychopharmacology (Berl) 197:217-27. 2008
    ..Marijuana use in adolescents is a highly social activity, and interacting endocannabinoid and opioid systems may modulate social reward. However, cannabinoid exposure has been reported to reduce social behavior...
  84. pmc Complementary modulation of somatic inhibition by opioids and cannabinoids
    Lindsey L Glickfeld
    Neurosciences Graduate Program, Neurobiology Section, University of California, San Diego, La Jolla, California 92093 0634, USA
    J Neurosci 28:1824-32. 2008
    ..Indeed, cannabinoids selectively suppress the output of one class of basket cell...
  85. pmc GPR55: a new member of the cannabinoid receptor clan?
    R G Pertwee
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, Scotland, UK
    Br J Pharmacol 152:984-6. 2007
    ..GPR55 was activated by a range of plant, synthetic and endogenous cannabinoids and blocked by the non-psychoactive phytocannabinoid, cannabidiol...
  86. pmc Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism
    M Donadelli
    Department of Life and Reproduction Sciences, Biochemistry Section, University of Verona, Verona, Italy
    Cell Death Dis 2:e152. 2011
    ..The purpose of our work was to improve GEM activity by addition of cannabinoids. Here, we show that GEM induces both cannabinoid receptor-1 (CB1) and cannabinoid receptor-2 (CB2) receptors by ..
  87. pmc Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer
    Zahida Qamri
    Department of Pathology, Ohio State University Medical Center, Columbus, OH 43210, USA
    Mol Cancer Ther 8:3117-29. 2009
    b>Cannabinoids have been reported to possess antitumorogenic activity. Not much is known, however, about the effects and mechanism of action of synthetic nonpsychotic cannabinoids on breast cancer growth and metastasis...
  88. pmc Pharmacological characterization of GPR55, a putative cannabinoid receptor
    Haleli Sharir
    Department of Anatomy and Cell Biology and Center for Substance Abuse Research, Temple University, Philadelphia, PA 19140, USA
    Pharmacol Ther 126:301-13. 2010
    ..Thus delineating the pharmacology of this receptor and the discovery of selective agonists and antagonists merits further study and could lead to new therapeutics...
  89. ncbi Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors
    C C Felder
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Mol Pharmacol 48:443-50. 1995
    ..Except for its inability to couple to the modulation of Q-type calcium channels or inwardly rectifying potassium channels, the CB1 and CB2 receptors display similar pharmacological and biochemical properties...
  90. pmc Effects of cannabinoids and cannabinoid-enriched Cannabis extracts on TRP channels and endocannabinoid metabolic enzymes
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, CNR, Pozzuoli NA, Italy
    Br J Pharmacol 163:1479-94. 2011
    ..Cannabidiol (CBD) and Δ(9) -tetrahydrocannabinol (THC) interact with transient receptor potential (TRP) channels and enzymes of the endocannabinoid system...
  91. ncbi The roles of cannabinoid and dopamine receptor systems in neural emotional learning circuits: implications for schizophrenia and addiction
    S R Laviolette
    Department of Neuroscience, The University of Pittsburgh, Pittsburgh, 458 Crawford Hall, Pennsylvania 15260, USA
    Cell Mol Life Sci 63:1597-613. 2006
    b>Cannabinoids represent one of the most widely used hallucinogenic drugs and induce profound alterations in sensory perception and emotional processing...
  92. ncbi Non-CB1, non-CB2 receptors for endocannabinoids, plant cannabinoids, and synthetic cannabimimetics: focus on G-protein-coupled receptors and transient receptor potential channels
    Luciano De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, Consiglio Nazionale delle Ricerche, 80078 Pozzuoli, NA, Italy
    J Neuroimmune Pharmacol 5:103-21. 2010
    ..do mediate most of the pharmacological actions of THC, they do not seem to act as receptors for other plant cannabinoids (phytocannabinoids), nor are they the unique targets of the endogenous lipids that were originally identified ..
  93. ncbi Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1
    Robert Ramer
    Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock D 18057, Germany
    J Natl Cancer Inst 100:59-69. 2008
    b>Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects...
  94. pmc Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain
    Cory C Toth
    Department of Clinical Neurosciences and the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Mol Pain 6:16. 2010
    ..One potential therapeutic option gaining clinical acceptance is the cannabinoids, for which cannabinoid receptors (CB) are expressed on neurons and microglia...
  95. pmc CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids
    Mohab M Ibrahim
    Department of Anesthesiology, University of Arizona College of Medicine, Tucson, AZ 85724 5114, USA
    Proc Natl Acad Sci U S A 102:3093-8. 2005
    ..This mechanism allows for the local release of beta-endorphin, where CB(2) receptors are present, leading to anatomical specificity of opioid effects...
  96. ncbi Cannabinoids and prefrontal cortical function: insights from preclinical studies
    Alice Egerton
    Department of Physiology and Pharmacology, Strathclyde Institute for Biomedical Sciences, University of Strathclyde, Glasgow G4 0NR, UK
    Neurosci Biobehav Rev 30:680-95. 2006
    ..Here, we review the contribution of preclinical research to understanding the effects of cannabinoids on cognitive ability, and the mechanisms by which cannabinoids may affect the neurochemical processes in the ..
  97. ncbi Cannabinoids: potential anticancer agents
    Manuel Guzman
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040 Madrid, Spain
    Nat Rev Cancer 3:745-55. 2003
    b>Cannabinoids - the active components of Cannabis sativa and their derivatives - exert palliative effects in cancer patients by preventing nausea, vomiting and pain and by stimulating appetite...
  98. pmc Analysis of the effects of cannabinoids on identified synaptic connections in the caudate-putamen by paired recordings in transgenic mice
    Ilka Freiman
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Albert Ludwigs Universitat, D 79104 Freiburg i Br, Germany
    J Physiol 575:789-806. 2006
    ..a method for studying identified synaptic connections in the caudate-putamen, and to determine the effects of cannabinoids on these connections...
  99. ncbi Cannabinoids modulate hippocampal memory and plasticity
    Hila Abush
    Department of Psychology, University of Haifa, Haifa, Israel
    Hippocampus 20:1126-38. 2010
    ..However, recent studies suggest that the effects of cannabinoids on learning do not necessarily follow these simple patterns, particularly when emotional memory processes are ..
  100. ncbi Cannabinoids in medicine: A review of their therapeutic potential
    Mohamed Ben Amar
    Substance Abuse Program, Faculties of Continuing Education and Graduate Studies, University of Montreal, C P 6128, Succursale Centre Ville, Montreal, Que H3C 3J7, Canada
    J Ethnopharmacol 105:1-25. 2006
    In order to assess the current knowledge on the therapeutic potential of cannabinoids, a meta-analysis was performed through Medline and PubMed up to July 1, 2005...
  101. pmc Endogenous cannabinoids mediate long-term synaptic depression in the nucleus accumbens
    David Robbe
    Actions Concertées Incitatives Jeunes Chercheurs Plasticité Synaptique et Toxicomanie, Centre National de la Recherche Scientifique, Unité Propre de Recherche 9023, 141 rue de la Cardonille, 34094 Montpellier Cedex 05, France
    Proc Natl Acad Sci U S A 99:8384-8. 2002
    ..These findings unveil the role of the eCB system in activity-dependent long-term synaptic plasticity and identify a mechanism by which marijuana can alter synaptic functions in the endogenous brain reward system...

Research Grants70

  1. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..In contrast, the function of related eicosanoids, cannabinoids (CB), in HSC development and PGE2-mediated repair has not been addressed...
  2. EFFECT OF DRUGS OF ABUSE ON NEURONAL REDOX AND METHYLATION STATUS
    Richard C Deth; Fiscal Year: 2012
    ..show that EAAT3- mediated cysteine uptake is also sensitive to opiates and ethanol, as well as nicotine and cannabinoids, suggesting that it may serve as a nexus for the epigenetic effects of abused drugs...
  3. Effects of Cannabinoids on the Immune Response to Murine Systemic Candidiasis
    NANCY ELIZABETH BUCKLEY-NIEVES; Fiscal Year: 2012
    ..e interferon-3 (IFN- 3)) while increasing Th2 cytokines (i.e. interleukin-4 (IL-4)). However the effect of cannabinoids on fungal infections is unknown...
  4. Sex Differences in the Cannabioid Regulation of Energy Homeostasis
    Edward J Wagner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cannabinoids exert a profound impact on the hypothalamic control of biological processes such as reproduction and energy homeostasis...
  5. CB1 Receptor Regulation by Cannabinoid Receptor Interacting Protein CRIP1a
    DANA E contact SELLEY; Fiscal Year: 2010
    ..CB1 receptors also mediate many effects of the lipid-derived endogenous cannabinoids (endocannabinoids)...
  6. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ..However, surprisingly little is known about the effects of cannabinoids on HIV-1 neuropathogenesis, despite the facts that cannabinoid receptors are abundantly expressed in the ..
  7. Role of cannabinoid 2 receptors in B lymphocyte function
    Catherine E Patterson; Fiscal Year: 2010
    The overall goal of this revised project is to determine the effect of cannabinoids and the role CB2 plays in the regulation of B cell function in order to better understand the immunomodulatory potential of cannabinoid-based drugs and ..
  8. High Specificity HIV-1 Markers Predictive of Neuro-AIDS
    Brian Wigdahl; Fiscal Year: 2013
    ..the development of HIV-associated neurocognitive disorders, study the impact of substance abuse (cocaine and cannabinoids) on these processes, and potentially help guide the therapeutic management of HIV disease...
  9. Cannabinoid Epigenomic and miRNA mechanisms impact HIV/SIV disease progression
    Patricia E Molina; Fiscal Year: 2013
    ..In addition, 9-THC decreased viral replication in an in vitro assay. While the ability of cannabinoids to suppress inflammation and viral replication has been reported by others and confirmed by our ongoing studies,..
  10. Cannabinoid Mechanisms in Human Gastrointestinal Motor and Sensory Functions
    MICHAEL L CAMILLERI; Fiscal Year: 2010
    ..There are endogenous cannabinoids (or endocannabinoids) such as anandamide and 2-arachidonyl glycerol...
  11. Searching for Novel Analgesic and Anti-inflammatory Agents
    Guigen Li; Fiscal Year: 2010
    ..co-PI, Professor Sumner Burstein at University of Massachusetts Medical School has been working in the area of cannabinoids since 1968...
  12. Transmucosal Intra-Oral Drug Delivery System for THC
    Mahmoud A ElSohly; Fiscal Year: 2010
    ..The increased interest in THC (and other cannabinoids) therapeutic activities necessitated the search for alternative delivery systems, as was recommended in the ..
  13. Characteristics and mechanisms of pain in sickle cell disease
    DONALD SIMONE; Fiscal Year: 2013
    ..hypotheses: (1) sickle mice exhibit cutaneous and deep hyperalgesia, which can be modulated by peripheral cannabinoids. We will examine cutaneous pain by measuring withdrawal responses to mechanical, heat and cold stimuli and deep/..
  14. Lipidomic profile of endocannabinoids from neuronal cells
    VINCENT JO DAVISSON; Fiscal Year: 2010
    ..strategies can be employed in in vivo or in vitro systems to better understand the profile of endogenous cannabinoids produced under a variety of stimuli...
  15. Cannabinoid modulation of microglial response to the HIV protein Tat
    Guy A Cabral; Fiscal Year: 2013
    ..provided by applicant): The goal of this project is to establish the functional relevance of exogenous cannabinoids in modulating responsiveness of microglia to the human immunodeficiency virus-1 (HIV-1) trans-activating (Tat) ..
  16. Polysubstance Use and Chronic Smoking: Neuroimaging and Cognition
    Dieter J Meyerhoff; Fiscal Year: 2010
    ..Chronic and excessive use of alcohol, methamphetamines, cocaine, cannabinoids, heroin, and tobacco products individually and in various combinations (i.e...
  17. ANTERIOR OCULAR SEGMENT PHYSIOLOGY AND PHARMACOLOGY
    Paul Kaufman; Fiscal Year: 2009
    ..mechanisms of intraocular pressure (IOP) reduction of other classes of potential glaucoma therapeutic agents (cannabinoids, nitric oxide donors, prostaglandin EP4 agonists, angiotensin and chymase), and their interactions with ..
  18. CB2 Receptor Regulatin of Inflammatory Response in EAE
    Ronald F Tuma; Fiscal Year: 2012
    ..O-1966 is a member of the cannabinoid class of molecules. While cannabinoids derived from the plant Cannabis Sativa have been used for thousands of years, their value in the treatment of ..
  19. Modulation of Pruritus by Spinal Cannabinoids
    Gregory W Terman; Fiscal Year: 2010
    ..WIN 55,212-2 in animals with GRP-induced scratching in hopes of demonstrating possible applications of cannabinoids for the treatment of itch...
  20. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Derivatives of Cannabis sativa (cannabinoids) are potent analgesics, and endogenous cannabinoids share this property...
  21. Endocannabinoid Signaling in Postnatal Ethanol Effects
    BASAVARAJ S BALAPAL; Fiscal Year: 2013
    ..to the hypothesis that ethanol exerts its effects on synaptic plasticity via increased production of endogenous cannabinoids [ECs;anandamide (AEA) and 2-arachidonylglycerol (2-AG)] in hippocampal neurons...
  22. Monoacylglycerol Lipase Inhibitors for Treating Opioid Use Disorders
    Aron H Lichtman; Fiscal Year: 2013
    ..Alternatively, increasing brain levels of the endogenous cannabinoids anandamide and 2-arachidonylglycerol (2-AG) though the blockade of their respective catabolic enzymes fatty ..
  23. BEHAVIORAL EFFECTS OF CB2 CANNABINOID RECEPTORS (CB2RS)
    Emmanuel S Onaivi; Fiscal Year: 2012
    ..b>Cannabinoids are the constituents in marijuana and endocannabinoids (eCBs) are the natural endogenous marijuana-like ..
  24. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Endogenous cannabinoids (endocannabinoids) are retrograde signaling molecules in the central nervous system...
  25. Transdermal Cannabidiol Prodrug Delivery
    Audra L Stinchcomb; Fiscal Year: 2011
    ..Cannabidiol (CBD) is a drug that could improve these three syndromes. Transdermal drug delivery of cannabinoids is a viable alternative to oral dosing. Most of the cannabinoids are highly metabolized in the liver...
  26. Glucocorticoids and endocannabinoids in vagal complex
    Bret N Smith; Fiscal Year: 2013
    ..Regulation of DMV neurons by cannabinoids, vanilloids, and glucocorticoids has been suggested;when applied centrally these compounds profoundly alter ..
  27. Synthetic cannabinoids as novel therapeutic strategies against non-small cell lun
    Ramesh K Ganju; Fiscal Year: 2012
    ..In our preliminary data, we have shown that cannabinoids derived from plants, such as D9-tetrahydrocannabinol, inhibit epidermal growth factor receptor (EGFR)-mediated ..
  28. Imaging Brain Cannabinoid Receptors (CB1) in Schizophrenia
    DEEPAK CYRIL D'SOUZA; Fiscal Year: 2013
    ..According to the better know exogenous hypothesis, 1) cannabinoids can produce a full range of transient schizophrenia-like effects in healthy individuals, 2) cannabinoids can ..
  29. Gender differences in peripheral cannabinoid mediated analgesia
    KATELYN YUEYI NIU; Fiscal Year: 2012
    ..Peripheral uses of cannabinoids have emerged as attractive alternatives or adjuncts to treatment with opioids, due to the centrally related ..
  30. Synaptic plasticity in adolescent cannabis users: relevance to schizophrenia
    Subroto Ghose; Fiscal Year: 2013
    ..In recent years, the K2 synthetic cannabinoids, compounds with high affinity for CB1 receptors, have been linked to inducing psychosis, implicating CB1 ..
  31. Cannabinoid-based therapy and approaches to quantify pain in sickle cell disease
    Kalpna Gupta; Fiscal Year: 2013
    ..Our general hypothesis is that neurogenic inflammation contributes to pain in SCD and that cannabinoids offer the unique advantage of providing analgesia by disrupting neurogenic inflammation and nociceptor ..
  32. Treatment of SLE with ajulemic acid, a non-psychoactive cannabinoid derivative
    Meggan Mackay; Fiscal Year: 2013
    ..Ajulemic acid (AjA) is derived from a class of cannabinoids that retain analgesic and anti-inflammatory properties without the psychotropic effects characteristic of ..
  33. Center of Research Excellence in Natural Products Neuroscience (CORE-NPN)
    STEPHEN JOHN CUTLER; Fiscal Year: 2013
    ..its academic home, the School of Pharmacy, have already reported groundbreaking observations on the roles of cannabinoids and non-cannabinoids in the etiology of weight control, the control of the immune system, treatment of cancer, ..
  34. Endogenous Cannabinoids and NGF Signaling in Pain Associated with Cystitis
    DALE EDMOND BJORLING; Fiscal Year: 2013
    ..Currently available options for controlling bladder pain are not effective in all patients. Endogenous cannabinoids (endocannabinoids) function to limit inflammatory pain, but very little is known about their function in the ..
  35. Cannabinoids Control Breast Cancer Progression Through Id-1
    Sean D McAllister; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: We hypothesize that cannabinoids, well-tolerated compounds that are already being used in clinical trials for purposes unrelated to their ..
  36. EM-TRANSMITTER INTERACTIONS OF STRIATAL OPIOID NEURONS
    Virginia M Pickel; Fiscal Year: 2013
    ..The results will have many important implications for understanding the cross-sensitization between opiates and cannabinoids and for devising new treatments for addictive diseases.
  37. Pulmonary and Immunologic Effects of Marijuana Use on HIV and Viral Immunity
    Michael D Roth; Fiscal Year: 2010
    ..In this competing renewal we focus on the role of cannabinoids as immunoregulatory molecules and the mechanisms by which THC suppresses host immunity and increases ..
  38. Presynaptic Forms of Long-Term Plasticity in the CNS
    Pablo E Castillo; Fiscal Year: 2013
    ..Recently, a new type of use-dependent synaptic plasticity that requires retrograde signaling by endogenous cannabinoids (endocannabinoids) has been identified in several brain structures...
  39. Mechanisms of Intercelllar Communication
    VYTAUTAS K VERSELIS; Fiscal Year: 2013
    ..Studies include mechanisms of LTP and LTD, role of endogenous cannabinoids and kinases, receptor distribution, cycling and synaptic plasticity at the systems level...
  40. Pharmacological modulation of synapses and cognition during HIV-1 neurotoxicity
    Stanley A Thayer; Fiscal Year: 2013
    ..The second aim is to determine the effects of cannabinoids, drugs given to AIDS patients clinically and widely used illicitly, on the synaptic and cognitive changes ..
  41. Sex Differences in Cannabinoid Dependence and Analgesia
    Jenny L Wiley; Fiscal Year: 2013
    ..these basic mechanisms underlying sex differences in antinociceptive and dependence-related effects of cannabinoids will facilitate development of sex-specific approaches to treat marijuana dependence and to use cannabinoid-..
  42. Neurogenesis and chronic cannabinoid exposure
    Colleen Cosgrove Hegg; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cannabinoids are increasingly being used in the treatment of chronic diseases, making it extremely important to understand their long-term effects...
  43. Endocannabinoid system and inhibition in bipolar disorder
    William Perry; Fiscal Year: 2013
    ..To study the EC system, cerebrospinal fluid (CSF) levels of the two primary endogenous cannabinoids, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), will be compared between euthymic BD subjects and healthy ..
  44. Neuroendocrine Supersensitivity of 5-HT2A Receptors
    GONZALO ANDRES CARRASCO; Fiscal Year: 2010
    ..Recent evidence also suggests that withdrawal from marijuana-related compounds (cannabinoids) is associated with supersensitivity of 5-HT2A receptors...
  45. Control of Breast Cancer by the Endocannabinoid System
    Sean McAllister; Fiscal Year: 2009
    ..research focusing on the classical cannabinoid agonist, ?9-tetrahydrocannabinol (?9-THC), and other synthetic cannabinoids. This proposal will focus on the potential treatment of human breast cancer using cannabinoids as selective ..
  46. CALCIUM WAVES IN PYRAMIDAL NEURONS
    William Ross; Fiscal Year: 2009
    ..A second set of experiments will examine the role of the Ca2+ waves in suppressing synaptic inhibition onto pyramidal neurons mediated by endogenous cannabinoids.
  47. Regulation of presympathetic RVLM neurons by cannabinoids
    ANDREI DERBENEV; Fiscal Year: 2009
    ..Endogenous cannabinoids (eCB), (e. g...
  48. Examination of endocannabinoid elevation and extinction learning
    JASON MICHAEL WIEBELHAUS; Fiscal Year: 2013
    ..9-THC is one of a group of exogenous cannabinoids that binds to and activates CB1 cannabinoid receptors that are widely distributed throughout the CNS...
  49. Selective CB2 Cannabinoid Agonists as Candidate Therapeutics for ALS
    PAUL PRATHER; Fiscal Year: 2009
    ..Neuroinflammation may greatly influence the progression of motor neuron loss during ALS. Cannabinoids produce anti-inflammatory actions via CB1 and CB2 receptors and delay the progression of pathologic conditions ..
  50. Cannabinoid Receptor Mechanisms in Accumbal Encoding of Extinction Learning
    JOSEPH FRANCOIS RENE CHEER; Fiscal Year: 2012
    It has been proposed that endogenous cannabinoids contribute to the valuation of various reinforcers including brain stimulation reward (BSR), highly palatable food and abused drugs such as cocaine, in part by modulating neurotransmitter ..
  51. Opioids, Cannabinoids, Chemokines: Functional Implications of Cross-Talk
    Martin W Adler; Fiscal Year: 2012
    ..Cross-talk between opioids or cannabinoids and chemokines (small proteins produced by both microglia and neurons in the brain) occurs both in vitro and in ..
  52. Characterization of anandamide transport in brain
    Daniele Piomelli; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The endogenous cannabinoids and their attending G protein-coupled receptors are components of a neuromodulatory system that regulates multiple brain functions, including pain and reward...
  53. CB1 Mediation of Cerebellum Versus Forebrain-Dependent Associative Learning
    PATRICK DAVID SKOSNIK; Fiscal Year: 2013
    ..such as short-term memory and attention, there are a paucity of data examining the effect of exogenous cannabinoids on associative learning, particularly as it relates to cerebellar versus forebrain-dependent classical eyeblink ..
  54. Role of the Endocannabinoid System in the Neurobiology of Depressive Behavior
    VINOD K YARAGUDRI; Fiscal Year: 2010
    ..The mood altering ability of cannabinoids, and reported changes in the CB1 receptor density in the postmortem brain of depressed suicide victims led us ..
  55. Endogenous/exogenous cannabinoids: A comparison
    TORBJORN U JARBE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Research on cannabinoids has progressed tremendously since the discovery of specific recognition sites (receptors) for chemicals like [unreadable]9-tetrahydrocannabinol (THC), the main active ..
  56. Endogenous Cannabinoids and Brain Function
    Aron H Lichtman; Fiscal Year: 2013
    ..or disease states and to determine the extent to which it serves as a mediator in the effects of exogenous cannabinoids. It is our premise that understanding the endogenous cannabinoid system will allow us to address public health ..
  57. Effects of Cannabinoids on Pain-Stimulated and Pain-Depressed Behavior in Rats
    Andrew J Kwilasz; Fiscal Year: 2013
    ..The primary goal of this project is to assess antinociceptive effects of CBs using a model that may be more predictive of analgesia in humans. ..
  58. HIV Neurotoxicity-Mechanism &Modulation by Cannabinoids
    Stanley A Thayer; Fiscal Year: 2013
    ..PSD loss was reversible. Cannabinoids, drugs given to AIDS patients clinically and widely used illicitly, modulate synapse loss...
  59. CB2 agonists as novel therapeutic agents that limit allergic lung inflammation
    Zeina Jaffar; Fiscal Year: 2012
    ..Little is known about the effects of cannabinoids on allergic inflammatory responses in the lung and the precise role of CB2 receptors in modulating allergic ..
  60. A novel cannabinoid receptor in cortical nerve terminals
    Stephen M Smith; Fiscal Year: 2011
    ..it has also been suggested that the extracellular Ca-sensing receptor (CaSR) would be a suitable target for cannabinoids. In preliminary experiments we found that cannabinoids activate CaSR, a G-protein coupled receptor (GPCR), that ..
  61. GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis
    DEEPAK CYRIL D apos SOUZA; Fiscal Year: 2010
    GABA Deficits and Vulnerability to Cannabinoid-Induced Psychosis Cannabinoids (CBs) induce transient psychotic symptoms and cognitive dysfunction in healthy individuals and exacerbate symptoms in schizophrenia patients...
  62. Modulation of norepinephrine by cannabinoids
    Elisabeth J Van Bockstaele; Fiscal Year: 2013
    ..Understanding the nature of state dependent alterations of this integrative system may provide a novel substrate for the treatment of stress-induced anxiety disorders. ..
  63. MECHANISMS OF CANNABINOIDS ANTIEMETIC ACTIONS
    NISSAR DARMANI; Fiscal Year: 2001
    ..Unlike D2- and 5-HT3- receptor antagonists, the mechanism of the antiemetic action of clinically useful cannabinoids is presently unknown...
  64. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..We propose to evaluate the hypothesis that cannabinoids, known to have central antinociceptive actions, also act in the periphery to modulate the activity of terminals ..
  65. MOTOR ACTIONS OF CANNABINOIDS IN A PARKINSONS MODEL
    CLARA SANUDO PENA; Fiscal Year: 2002
    ..In recent studies we have described a major modulatory role of cannabinoids in the basal ganglia where they act on both major excitatory (subthalamic) and major inhibitory (striatal) ..
  66. CANNABINOIDS AND THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS
    Laura Murphy; Fiscal Year: 2002
    ..This proposal will focus on the effects of cannabinoids on the hypothalamic-pituitary-adrenal (HPA) axis, a system which plays a critical role in coordinating the ..
  67. CANNABINOID-INDUCED DISRUPTION OF THE REPRODUCTIVE AXIS
    Edward Wagner; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) One of the principal actions of cannabinoids is to inhibit the secretion of the important reproductive hormones luteinizing hormone (LH) and prolactin (PRL) from the anterior pituitary via a ..
  68. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2001
    ..The active ingredients of this drug, which include delta9-tetrahydrocannabinol (THC), are collectively known as cannabinoids (CBs)...
  69. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2006
    ..The active ingredients of this drug, which include delta9-tetrahydrocannabinol (THC), are collectively known as cannabinoids (CBs)...
  70. Cannabinoid modulation of epileptiform activity in mice
    Bret Smith; Fiscal Year: 2006
    ..this Exploratory/Developmental (R21) research proposal is to identify the effects of exogenous and endogenous cannabinoids on neurons of the dentate gyrus in mice with pilocarpine-induced temporal lobe epilepsy (TLE), characterized by ..