fluorocarbons

Summary

Summary: Liquid perfluorinated carbon compounds which may or may not contain a hetero atom such as nitrogen, oxygen or sulfur, but do not contain another halogen or hydrogen atom. This concept includes fluorocarbon emulsions and fluorocarbon blood substitutes.

Top Publications

  1. ncbi Perfluoroalkyl acids: a review of monitoring and toxicological findings
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:366-94. 2007
  2. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
  3. pmc Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study
    Eva C Bonefeld-Jorgensen
    Centre for Arctic Environmental Medicine, Department of Public Health, Aarhus University, Denmark
    Environ Health 10:88. 2011
  4. ncbi Polyfluorinated compounds: past, present, and future
    Andrew B Lindstrom
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States
    Environ Sci Technol 45:7954-61. 2011
  5. pmc Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 118:1100-8. 2010
  6. ncbi Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
  7. ncbi Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, CA, USA
    Environ Sci Technol 45:1435-42. 2011
  8. pmc The C8 health project: design, methods, and participants
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9105, USA
    Environ Health Perspect 117:1873-82. 2009
  9. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
  10. pmc Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, California 95616, USA
    Environ Health Perspect 119:1760-5. 2011

Research Grants

Detail Information

Publications280 found, 100 shown here

  1. ncbi Perfluoroalkyl acids: a review of monitoring and toxicological findings
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 99:366-94. 2007
    ..Several avenues of research are proposed that would further our understanding of this class of compounds...
  2. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
    ..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
  3. pmc Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study
    Eva C Bonefeld-Jorgensen
    Centre for Arctic Environmental Medicine, Department of Public Health, Aarhus University, Denmark
    Environ Health 10:88. 2011
    ..This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their controls, and whether the combined POP related effect on nuclear hormone receptors affect BC risk...
  4. ncbi Polyfluorinated compounds: past, present, and future
    Andrew B Lindstrom
    National Exposure Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, United States
    Environ Sci Technol 45:7954-61. 2011
    ..The utility of these compounds seems to ensure their continued use in one form or another for the foreseeable future, presenting a long-term challenge to scientists, industry leaders, and public health officials worldwide...
  5. pmc Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 118:1100-8. 2010
    ..OBJECTIVE AND SOURCES: We reviewed the epidemiologic literature for PFOA...
  6. ncbi Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
    ..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
  7. ncbi Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, CA, USA
    Environ Sci Technol 45:1435-42. 2011
    ..87. These models may be useful for estimating past and future public well water PFOA concentrations in this region...
  8. pmc The C8 health project: design, methods, and participants
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9105, USA
    Environ Health Perspect 117:1873-82. 2009
    ..The settlement stemmed from the perfluorooctanoic acid (PFOA, or C8) contamination of drinking water in six water districts in two states near the DuPont Washington Works facility near Parkersburg, West Virginia...
  9. pmc Ultrasound-mediated tumor imaging and nanotherapy using drug loaded, block copolymer stabilized perfluorocarbon nanoemulsions
    Natalya Rapoport
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    J Control Release 153:4-15. 2011
    ..Anticipated mechanisms of the observed effects are discussed...
  10. pmc Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, California 95616, USA
    Environ Health Perspect 119:1760-5. 2011
    ..People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities...
  11. ncbi Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals
    Naomi Kudo
    Department of Toxicology and Applied Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Toxicol Sci 28:49-57. 2003
    ..Elucidation of the mechanisms of transport in biological systems leads to elimination and detoxification of this chemical in the human body...
  12. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
    ....
  13. ncbi Global distribution of perfluorooctane sulfonate in wildlife
    J P Giesy
    Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 35:1339-42. 2001
    ..Currently available data indicate that the concentrations of PFOS in wildlife are less than those required to cause adverse effects in laboratory animals...
  14. pmc Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study
    Thorhallur I Halldorsson
    Center for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark
    Environ Health Perspect 120:668-73. 2012
    ..A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in postpubertal female offspring...
  15. pmc Formulation and acoustic studies of a new phase-shift agent for diagnostic and therapeutic ultrasound
    Paul S Sheeran
    Joint Department of Biomedical Engineering, University of North Carolina and North Carolina State University, Chapel Hill, North Carolina 27599, USA
    Langmuir 27:10412-20. 2011
    ..This methodology offers a new means of developing extravascular contrast agents for diagnostic and therapeutic applications...
  16. ncbi Emerging endocrine disrupters: perfluoroalkylated substances
    Allan Astrup Jensen
    FORCE Technology, Broendby, Denmark
    Int J Androl 31:161-9. 2008
    ..However, hundreds of related chemicals: homologues with shorter or longer alkyl chain, PFOA and telomers, which potentially may degrade to perfluoroalkanoic (carboxylic) acids, are not regulated...
  17. ncbi Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha
    Jamie C DeWitt
    East Carolina University, Greenville, North Carolina, USA
    Crit Rev Toxicol 39:76-94. 2009
    ..This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPARalpha ligands of therapeutic and environmental interest...
  18. ncbi Cohort mortality study of workers exposed to perfluorooctanoic acid
    Kyle Steenland
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 176:909-17. 2012
    ..These results were limited by small numbers and restriction to mortality data, which are of limited relevance for several nonfatal outcomes of a priori interest...
  19. pmc Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
    Jessica W Nelson
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:197-202. 2010
    ..Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation...
  20. pmc Neuroendocrine effects of perfluorooctane sulfonate in rats
    Maureen E Austin
    Neuroendocrine Research Laboratory, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Center, Michigan State University, East Lansing, MI 48824, USA
    Environ Health Perspect 111:1485-9. 2003
    ..PFOS treatment also increased norepinephrine concentrations in the paraventricular nucleus of the hypothalamus. These results indicate that exposure to PFOS can affect the neuroendocrine system in rats...
  21. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  22. ncbi Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X rec
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
    Toxicol Sci 92:476-89. 2006
    ..Compared to naturally occurring long-chain fatty acids, e.g. linoleic and alpha-linolenic acids, these perfluorinated fatty acid analogs were more selective and less potent in their activation of the NRs...
  23. pmc Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia
    Scott M Bartell
    Program in Public Health, University of California, Irvine, California 92697 1250, USA
    Environ Health Perspect 118:222-8. 2010
    ..Two highly contaminated water districts began granular activated carbon filtration in 2007...
  24. pmc Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community
    David A Savitz
    Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
    Epidemiology 23:386-92. 2012
    ..We assessed the association between perfluorooctanoic acid (PFOA) and pregnancy outcome in an area with elevated exposure to PFOA from drinking water contaminated by chemical plant releases...
  25. ncbi Perfluorinated compounds--exposure assessment for the general population in Western countries
    Hermann Fromme
    Department of Environmental Health, Bavarian Health and Food Safety Authority, Veterinärstrasse 2, 85764 Oberschleissheim, Germany
    Int J Hyg Environ Health 212:239-70. 2009
    ..This has been observed in populations living near PFC production facilities or in areas with environmental contamination of PFCs. The consumption of highly contaminated fish products may also cause an increase in PFC body burdens...
  26. ncbi Ammonium perfluorooctanoate production and occupational mortality
    Jessica I Lundin
    Division of Environmental Health Sciences, University of Minnesota, School of Public Health, Minneapolis, MN 55455, USA
    Epidemiology 20:921-8. 2009
    ..Perfluorooctanoate (PFOA) is a synthetic chemical widely detectable in blood of nonoccupationally exposed persons. Its human health effects are not well-characterized...
  27. ncbi Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, United States
    Environ Sci Technol 46:6330-8. 2012
    ..8 years reported in individuals. This similarity supports the conclusion that the dominant PFOS-related exposures to humans in the United States were greatly mitigated during the phase-out period...
  28. ncbi Exposure to perfluorinated compounds and human semen quality in Arctic and European populations
    G Toft
    Department of Occupational Medicine, Danish Ramazzini Center, Aarhus University Hospital, Norrebrogade 44, Building 2C, Aarhus C 8000, Denmark
    Hum Reprod 27:2532-40. 2012
    ..Perfluorinated compounds (PFCs) have been suspected to adversely affect human reproductive health. The aim of this study was to investigate the associations between PFC exposure and male semen quality...
  29. ncbi Perfluorinated chemicals in selected residents of the American continent
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy, NE, Mailstop F17, Atlanta, GA 30341, USA
    Chemosphere 63:490-6. 2006
    ..Genetic variability, diet, lifestyle, or a combination of all these may contribute to the different patterns of human exposure to PFCs in the United States and Peru...
  30. ncbi A facile preparation method of a PFC-containing nano-sized emulsion for theranostics of solid tumors
    Kouichi Shiraishi
    Medical Engineering Laboratory, Research Center for Medical Science, The Jikei University School of Medicine, 3 25 8, Nishi Shinbashi, Minato ku, Tokyo 105 8461, Japan
    Int J Pharm 421:379-87. 2011
    ..200nm. Additionally, we prepared these small emulsions at 40°C, which is above the boiling temperature of PFC5. Accordingly, we succeeded in obtaining very small nano-emulsions for theranostics through a very facile method...
  31. pmc Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age
    Kate Hoffman
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 118:1762-7. 2010
    ..Exposures in the United States and in world populations are widespread. PFC exposures have been linked to various health impacts, and data in animals suggest that PFCs may be potential developmental neurotoxicants...
  32. pmc Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 116:1391-5. 2008
    ..Animal studies have shown that they may affect neuromuscular development at high concentrations...
  33. ncbi Serum vaccine antibody concentrations in children exposed to perfluorinated compounds
    Philippe Grandjean
    Department of Environmental Health, Harvard School of Public Health, 401 Park Dr, EOME 3E 110, Boston, MA 02215, USA
    JAMA 307:391-7. 2012
    ..They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood...
  34. ncbi Retrospective exposure assessment of perfluorooctanoic acid serum concentrations at a fluoropolymer manufacturing plant
    Susan R Woskie
    Department of Work Environment, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
    Ann Occup Hyg 56:1025-37. 2012
    ..8 for internal data comparisons and 0.6 for external data comparisons). These annualized PFOA serum estimates will be used in a series of morbidity and mortality studies of this worker cohort...
  35. ncbi Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study
    Linda Hanssen
    Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Environ Monit 12:1355-61. 2010
    ..Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products...
  36. pmc Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, 1 Medical Center Drive, Morgantown, WV 26506 9105, USA
    Arch Pediatr Adolesc Med 164:860-9. 2010
    ..Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are man-made compounds with widespread presence in human sera. In previous occupational and adult studies, PFOA and PFOS were positively associated with serum lipid levels...
  37. ncbi Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
  38. ncbi Pre- and postnatal exposure to perfluorinated compounds (PFCs)
    Hermann Fromme
    Department of Chemical Safety and Toxicology Biomonitoring, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D 80538 Munich, Germany
    Environ Sci Technol 44:7123-9. 2010
    ..Although the concentrations in breast milk were low, this intake led to a body burden at the age of six months similar to (PFOS) or higher than (PFOA) that found in adults...
  39. pmc Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1596-602. 2007
    ..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
  40. pmc Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
    Noriaki Washino
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Environ Health Perspect 117:660-7. 2009
    ..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
  41. ncbi Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain
    Niclas Johansson
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicol Sci 108:412-8. 2009
    ..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects...
  42. ncbi Fluorine-19 MRI for visualization and quantification of cell migration in a diabetes model
    Mangala Srinivas
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Magn Reson Med 58:725-34. 2007
    ..The labeling procedure did not affect T-cell migration in vivo. This imaging platform is applicable to many cell types and disease models and can potentially be used for monitoring the trafficking of cellular therapeutics...
  43. ncbi Maternal levels of perfluorinated chemicals and subfecundity
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California Los Angeles, PO Box 951772, 71 254 CHS, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Hum Reprod 24:1200-5. 2009
    ..Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are ubiquitous man-made compounds that are possible hormonal disruptors. We examined whether exposure to these compounds may decrease fecundity in humans...
  44. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  45. ncbi Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate
    Margy L Takacs
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:108-17. 2007
    ....
  46. pmc Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey
    David Melzer
    Epidemiology and Public Health Group, eninsula Medical School, Exeter, United Kingdom
    Environ Health Perspect 118:686-92. 2010
    ..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...
  47. ncbi Perfluoroalkyl acids and related chemistries--toxicokinetics and modes of action
    Melvin E Andersen
    The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Sci 102:3-14. 2008
    ..This report summarizes the discourse that occurred during the symposium...
  48. ncbi Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
  49. pmc Geocoding rural addresses in a community contaminated by PFOA: a comparison of methods
    VERONICA M VIEIRA
    Department of Environmental Health, Boston University School of Public Health, MA 02116, USA
    Environ Health 9:18. 2010
    ..Our study compared automated and E911 methods for recovering and geocoding valid street addresses and assessed the impact of positional errors on exposure classification...
  50. pmc Mechanisms of nucleotide trafficking during siRNA delivery to endothelial cells using perfluorocarbon nanoemulsions
    Megan M Kaneda
    Biomedical Engineering, Washington University School of Medicine, St Louis, MO 63108, USA
    Biomaterials 31:3079-86. 2010
    ..We further demonstrate markedly enhanced efficacy over conventional transfection agents for suppressing endothelial cell expression of upregulated vascular adhesion molecules...
  51. ncbi Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators
    Thoudam S K Singh
    Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
    Toxicol Lett 210:64-70. 2012
    ..Our findings provide evidence that PFOA, the known immunotoxic agent, induces mast cell-derived allergic inflammatory reactions by histamine release and expression of pro-inflammatory cytokines...
  52. pmc Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Toxicol Environ Health A 73:819-36. 2010
    ..The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level...
  53. pmc Assaying macrophage activity in a murine model of inflammatory bowel disease using fluorine-19 MRI
    Deepak K Kadayakkara
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Lab Invest 92:636-45. 2012
    ..Due to its high macrophage specificity and quantitative ability, we envisage (19)F MRI having an important role in evaluating a wide range of chronic inflammatory conditions mediated by macrophages...
  54. ncbi Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice
    Naomi Kudo
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Biol Pharm Bull 34:856-64. 2011
    ....
  55. ncbi Aptamer-conjugated and drug-loaded acoustic droplets for ultrasound theranosis
    Chung Hsin Wang
    Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu 30013, Taiwan, ROC
    Biomaterials 33:1939-47. 2012
    ..In conclusion, our fabricated droplets functioned as a hybrid chemical and mechanical strategy for the specific destruction of cancer cells upon ultrasound-mediated ADV, while simultaneously providing ultrasound imaging capability...
  56. ncbi Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
    Jessica Berthiaume
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 10 University Drive, Duluth, MN 55812 2496, USA
    Toxicol Lett 129:23-32. 2002
    ..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators...
  57. pmc Prenatal exposure to perfluorinated chemicals and behavioral or coordination problems at age 7 years
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, Los Angeles, California 90095, USA
    Environ Health Perspect 119:573-8. 2011
    ..We therefore investigated whether prenatal exposure to perfluorooctanoic acid (PFOA) or perfluorooctane sulfate (PFOS), two of the most prevalent PFCs, are associated with behavioral or coordination problems in early childhood...
  58. ncbi Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway
    Hyun Gyo Lee
    Department of Pharmacology and Toxicology, School of Medicine, Catholic University of Daegu, Daegu, South Korea
    Neurotoxicology 33:314-20. 2012
    ..Thus, this study may contribute to understand a new mechanistic aspect of PFOS-induced neurotoxicities...
  59. ncbi Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring
    Tian Chen
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Reprod Toxicol 33:538-45. 2012
    ..The results indicate that oxidative stress and both intrinsic and extrinsic cell death pathways were involved in prenatal PFOS exposure-induced injuries in postnatal lungs...
  60. ncbi Alterations in cell membrane properties caused by perfluorinated compounds
    Wen yue Hu
    National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Comp Biochem Physiol C Toxicol Pharmacol 135:77-88. 2003
    ..This suggests that PFOS effects membrane properties at concentrations below those associated with other adverse effects...
  61. ncbi Determinants of plasma PFOA and PFOS levels among 652 Danish men
    Kirsten T Eriksen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Sci Technol 45:8137-43. 2011
    ..Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation...
  62. ncbi Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures
    Seung Kyu Kim
    School of Earth and Environmental Sciences BK 21, Seoul National University, Kwanakgu Shilimdong san 56 1, Seoul 151 742, Republic of Korea
    Environ Pollut 159:169-74. 2011
    ..Accordingly, compound- and matrix-specific transfer must be considered when assessing prenatal and postnatal exposure...
  63. ncbi Bioconcentration and tissue distribution of perfluorinated acids in rainbow trout (Oncorhynchus mykiss)
    Jonathan W Martin
    University of Guelph, Department of Environmental Biology, Bovey Building, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:196-204. 2003
    ....
  64. ncbi Placental transfer of perfluorinated compounds is selective--a Norwegian Mother and Child sub-cohort study
    Kristine Bjerve Gutzkow
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Chemical Toxicology, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Int J Hyg Environ Health 215:216-9. 2012
    ..Additionally, the sulfonate group seems to impede transfer efficiency. This indicates a selective placental passage of the different PFCs and hence a specific foetal exposure...
  65. ncbi Sonochemical decomposition of perfluorooctane sulfonate and perfluorooctanoic acid
    Hiroshi Moriwaki
    Osaka City Institute of Public Health and Environmental Sciences, 8 34, Tojo cho, Tennoji ku, Osaka 543 0026, Japan
    Environ Sci Technol 39:3388-92. 2005
    ....
  66. ncbi Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats
    John L Butenhoff
    3M Company, Medical Department, 3M Center 220 06 W 08, Saint Paul, MN 55144, USA
    Toxicology 298:1-13. 2012
    ..All other tumor types were those seen spontaneously in rats of this stock and age and were not associated with feeding of APFO...
  67. ncbi Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
    J A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA
    Toxicology 288:8-17. 2011
    ....
  68. pmc Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles
    Walter J Akers
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, Saint Louis, Missouri 63108, United States
    ACS Nano 5:173-82. 2011
    ....
  69. ncbi Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Environ Sci Technol 45:8160-6. 2011
    ..In conclusion, our study showed a later age of puberty in this population correlated with PFC concentrations...
  70. ncbi Noninvasive detection of graft rejection by in vivo (19) F MRI in the early stage
    U Flogel
    Cardiovascular Physiology, Heinrich Heine University Dusseldorf, Germany
    Am J Transplant 11:235-44. 2011
    ..Thus, PFCs can serve as positive contrast agent for the early detection of transplant rejection by (19) F MRI with high spatial resolution and an excellent degree of specificity due to lack of any (19) F background...
  71. pmc Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water
    Debapriya Mondal
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Environ Health Perspect 120:752-7. 2012
    ..This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water...
  72. ncbi Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples
    Rocio Monroy
    Department of Obstetrics and Gynecology, McMaster University, HSC 3N52D, 1200 Main Street West, Hamilton, Ontario, Canada
    Environ Res 108:56-62. 2008
    ..Taken together our data demonstrate that although there is widespread exposure to PFCs during development, these exposures do not affect birth weight...
  73. ncbi Long lived microbubbles for oxygen delivery
    Frederic Gerber
    Systemes Organises Fluores a Finalites Therapeutiques SOFFT, Institut Charles Sadron, Strasbourg Cedex, France
    Artif Cells Blood Substit Immobil Biotechnol 35:119-24. 2007
    ..An unexpected, strong synergistic effect between the fluorocarbon gas and the fluorinated phospholipid has been discovered. Such bubbles could be used for in vivo oxygen delivery, ultrasound contrast imaging and drug delivery...
  74. ncbi 19F magnetic resonance imaging of endogenous macrophages in inflammation
    Sebastian Temme
    Institut für Molekulare Kardiologie, Heinrich Heine Universitat Dusseldorf, Dusseldorf, Germany
    Wiley Interdiscip Rev Nanomed Nanobiotechnol 4:329-43. 2012
    ..Because PFCs are biochemically inert and the fluorine nucleus exhibits high magnetic resonance (MR) sensitivity, (19) F MRI may be applicable for clinical inflammation imaging...
  75. ncbi Isomer distribution of perfluorocarboxylates in human blood: potential correlation to source
    Amila O De Silva
    Department of Chemistry, University of Toronto, 80 St George Street, Toronto, Ontario, Canada M5S 3H6
    Environ Sci Technol 40:2903-9. 2006
    ..Predominance of linear PFCA isomers and the [even PFCA] > [odd PFCA] concentration trend in blood is suggestive of additional input from a strictly linear perfluoroalkyl source...
  76. pmc Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains
    Chengfeng Yang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Reprod Toxicol 27:299-306. 2009
    ..This underscores the need for caution when drawing conclusions about the effects of PFOA and possibly other environmental pollutants on the basis of studies in a single mouse strain...
  77. ncbi Tracking the pathways of human exposure to perfluorocarboxylates
    Robin Vestergren
    Department of Applied Environmental Science ITM, Stockholm University, Svante Arrhenius väg 8C, SE 10691 Stockholm, Sweden
    Environ Sci Technol 43:5565-75. 2009
    ..5-5.5 of the daily intakes derived from exposure media, which provides further supporting evidence that dietary exposure is a major ongoing exposure pathway of PFOA to the background population...
  78. pmc Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from Dallas, Texas, USA
    Arnold Schecter
    Division of Environmental and Occupational Health Sciences, University of Texas School of Public Health, Dallas, Texas 75390, USA
    Environ Health Perspect 118:796-802. 2010
    ..2010. Polybrominated diphenyl ethers (PBDEs) and hexabromocyclodecane (HBCD) in composite U.S. food samples, Environ Health Perspect 118:357-362]...
  79. pmc (19)F MRI for quantitative in vivo cell tracking
    Mangala Srinivas
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    Trends Biotechnol 28:363-70. 2010
    ..We review the application of (19)F MRI to cell tracking, discussing intracellular (19)F labels, cell labeling and in vivo quantification, as well as the potential clinical uses of (19)F MRI...
  80. pmc Difluorinated-curcumin (CDF): a novel curcumin analog is a potent inhibitor of colon cancer stem-like cells
    Shailender Singh Kanwar
    Veterans Affairs Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Pharm Res 28:827-38. 2011
    ....
  81. ncbi 19F magnetic resonance imaging for stem/progenitor cell tracking with multiple unique perfluorocarbon nanobeacons
    Kathryn C Partlow
    Department of Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    FASEB J 21:1647-54. 2007
    ..This method should facilitate longitudinal investigation of cellular events in vivo for multiple cell types simultaneously...
  82. ncbi Sources, fate and transport of perfluorocarboxylates
    Konstantinos Prevedouros
    Department of Applied Environmental Science ITM, Stockholm University, SE 10691 Stockholm, Sweden
    Environ Sci Technol 40:32-44. 2006
    ..It was estimated that 2-12 tonnes/ year of PFO are transported to the Artic by oceanic transport, which is greater than the amount estimated to result from atmospheric transport/degradation of precursors...
  83. pmc The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water
    Lynda A Nolan
    Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Reprod Toxicol 27:231-8. 2009
    ..Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population...
  84. pmc Perfluorochemical (PFC) exposure in children: associations with impaired response inhibition
    Brooks B Gump
    Syracuse University, Syracuse New York 13244, United States
    Environ Sci Technol 45:8151-9. 2011
    ..In stark contrast to this widespread exposure to PFCs, there is relatively little research on potential adverse health effects of exposure to these chemicals...
  85. pmc Effects of perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells
    Andreas Wemhoner
    University Hospital Dresden, Department for Pediatric Intensive Care and Neonatology, Technical University Dresden, Germany
    Respir Res 11:52. 2010
    ..PFC have been shown to affect various cell types. Thus, effects on alveolar type II (ATII) cells and surfactant metabolism can be expected, data, however, are controversial...
  86. ncbi Investigation of vaporized submicron perfluorocarbon droplets as an ultrasound contrast agent
    Nikita Reznik
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Ultrasound Med Biol 37:1271-9. 2011
    ..These results suggest that submicron perfluorocarbon droplets, activated in situ, may be a candidate for an extravascular ultrasound contrast agent...
  87. ncbi Use of newborn screening program blood spots for exposure assessment: declining levels of perluorinated compounds in New York State infants
    Henry M Spliethoff
    Wadsworth Center, New York State Department of Health, Empire State Plaza, P O Box 509, Albany, New York 12201, USA
    Environ Sci Technol 42:5361-7. 2008
    ..Our results suggest sharp decreases in perinatal exposure of NYS infants to PFOS, PFOSA, PFHxS, and PFOA and demonstrate, for the first time, the utility of NSP blood spots for assessment of temporal trends in exposure...
  88. ncbi Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:258-65. 2009
    ..Because results in WT and KO were comparable, it is concluded that PFOS-induced neonatal lethality and delayed eye opening are not dependent on activation of PPAR alpha...
  89. ncbi An assessment of the exposure of Americans to perfluorooctane sulfonate: a comparison of estimated intake with values inferred from NHANES data
    Peter P Egeghy
    Office of Research and Development, U S Environmental Protection Agency, National Exposure Research Laboratory, 109 TW Alexander Dr MD E205 04, Research Triangle Park, North Carolina 27711, USA
    J Expo Sci Environ Epidemiol 21:150-68. 2011
    ..2 ng/kg-bw/day, and the forward-based intake estimates are within this range. The favorable comparison reported between the forward-modeled and the back-calculated range of intake predictions lends validity to the proposed framework...
  90. pmc Early assessment of pulmonary inflammation by 19F MRI in vivo
    Bernd Ebner
    Institut für Herz und Kreislaufphysiologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Circ Cardiovasc Imaging 3:202-10. 2010
    ..This study tests the hypothesis that (19)F MRI can be used to quantitate pulmonary inflammation by tracking of infiltrating PFC-loaded monocytes...
  91. ncbi An in vitro study of a phase-shift nanoemulsion: a potential nucleation agent for bubble-enhanced HIFU tumor ablation
    Peng Zhang
    Department of Mechanical Engineering, Boston University, Boston, MA, USA
    Ultrasound Med Biol 36:1856-66. 2010
    ..The results from this study demonstrate that phase-shift nanoemulsions can be combined with HIFU to provide a high degree of spatial and temporal control of bubble-enhanced heating...
  92. ncbi Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort
    Krista Yorita Christensen
    Epidemiology Department, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Int 37:129-35. 2011
    ..We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom to conduct a nested case-control study examining the association between age at menarche, and exposure to PFCs during pregnancy...
  93. ncbi Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure
    Line S Haug
    Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Int 37:687-93. 2011
    ..Even though food in general is the major source of exposure for PFCs, the indoor environment may be an important contributor to human exposure. This study provides valuable knowledge for risk assessment of PFCs and control strategies...
  94. ncbi Self-reported health effects among community residents exposed to perfluorooctanoate
    Pamela Anderson-Mahoney
    New Solut 18:129-43. 2008
    ..60, 95% C.I.=2.92-4.44; SPR=2.05, 95% C.I.=1.70-2.46; SPR=1.82, 95% C.I.=1.47-2.25, respectively), and other serious health problems. The increased prevalence of adverse health effects may be due to PFOA. Further study is needed...
  95. ncbi Tissue nitrogen elimination in oxygen-breathing pigs is enhanced by fluorocarbon-derived intravascular micro-bubbles
    C Lundgren
    Department of Physiology and Biophysics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Undersea Hyperb Med 32:215-26. 2005
    ..v. infusion of a small dose of 2 % DDFP-emulsion very effectively enhanced denitrogenation by oxygen breathing and deserve study as a means to improve prevention and treatment of decompression sickness...
  96. ncbi Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)
    Marie Ludivine Chateau-Degat
    Axe santé des populations et environnementale, Research center of the Centre hospitalier universitaire de Québec and Université Laval, Quebec, QC, Canada G1V 2M2
    Environ Res 110:710-7. 2010
    ..The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols...
  97. ncbi Maternal exposure to perfluorinated acids and fetal growth
    Michele P Hamm
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Expo Sci Environ Epidemiol 20:589-97. 2010
    ..These results suggest that maternal PFA exposure has no substantial effect on fetal weight and length of gestation at the concentrations observed in this population...
  98. pmc A pilot randomized clinical safety study of sonothrombolysis augmentation with ultrasound-activated perflutren-lipid microspheres for acute ischemic stroke
    Andrei V Alexandrov
    Comprehensive Stroke Center Neurology, The University of Alabama at Birmingham, RWUH M226, 619 19th St South, Birmingham, AL 35249 3280, USA
    Stroke 39:1464-9. 2008
    ..Ultrasound transiently expands perflutren-lipid microspheres (muS), transmitting energy momentum to surrounding fluids. We report a pilot safety/feasibility study of ultrasound-activated muS with systemic tissue plasminogen activator (tPA)...
  99. ncbi High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a simil
    Mousumi R Qazi
    Department of Biochemistry and Biophysics, Arrhenius Laboratories for the Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    Toxicology 262:207-14. 2009
    ..001%, w/w). These findings reveal that in addition to suppressing adaptive immunity, high-dose, short-term exposure of mice to either PFOS or PFOA augments inflammatory responses to LPS, a potent activator of innate immunity...
  100. ncbi Historic dietary exposure to perfluorooctane sulfonate, perfluorinated carboxylates, and fluorotelomer unsaturated carboxylates from the consumption of store-bought and restaurant foods for the Canadian population
    Sonja K Ostertag
    Centre for Indigenous Peoples Nutrition and Environment and Department of Natural Resource Sciences, McGill University, Macdonald Campus, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    J Agric Food Chem 57:8534-44. 2009
    ..Further research on the sources of contamination of processed and preprepared foods is required. Dietary exposure to PFCs among Canadians poses minimal health risks based on current toxicological information...
  101. ncbi Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis
    Lin Cui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Arch Environ Contam Toxicol 56:338-49. 2009
    ..The definite toxicity and high accumulation of the tested PFCs might pose a great threat to biota and human beings due to their widespread application in various fields...

Research Grants65

  1. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..b>Fluorocarbons will include F- decalin, F-tributylamine, and F-phenanthrene...
  2. RADIOPAQUE FLUOROCARBON IN DIAGNOSTIC RADIOLOGY
    David Long; Fiscal Year: 1980
    Radiopaque fluorocarbons (RFC) are new compounds in diagnostic radiology, and these compounds have unique and valuable characteristics that are not shared with other radiologic contrast agents...
  3. NOVEL CLASS OF FLUOROCARBONS AS BLOOD SUBSTITUTES
    Gordhan Patel; Fiscal Year: 1990
    ..The efficacy of the proposed fluorochemicals as blood substitute will be determined using mice. It is expected that some of the proposed fluorochemicals would prevent clearance of the particles by the reticulolendotential system...
  4. EXAMINATION OF PERFUSION OF THE HEART BY 19F NMR
    Craig Malloy; Fiscal Year: 1990
    ..The long term objectives of the proposed research include the determination of the potentials of fluorocarbons in (a) aiding in the clinical management of ischemic heart disease and (b) as agents for NMR imaging for ..
  5. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2002
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  6. ULTRASOUND ENHANCEMENT OF CANCER GENE THERAPY
    Douglas Miller; Fiscal Year: 2003
    ..This research will provide a bridge from the basic research breakthrough to specific therapeutic applications and urgently needed clinical research programs utilizing this novel technology. ..
  7. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2001
    ..abstract_text> ..
  8. BIOEFFECTS OF GAS BODY ACTIVATION IN MEDICAL ULTRASOUND
    Douglas Miller; Fiscal Year: 2009
    ..This project will examine bioeffects in cells and tissues and show how to safely use ultrasound contrast agents in diagnostic imaging. ..
  9. 1702 METABOLITE AND FLUOROCARBON FOR CARDIAC NMR IMAGING
    SIGMUND LASKER; Fiscal Year: 1992
    ..The role of the accumulation of the fluorocarbons at the altered local site as a potential kinetic enhancer of the conversion is at present unknown and will be ..
  10. Contrast-Enhanced Ultrasound Detection of Angiogenesis
    Flemming Forsberg; Fiscal Year: 2004
    ..If successful, this project will permit non-invasive ultrasound evaluations of anti-angiogenic tumor therapies in animals as well as humans. ..
  11. Subharmonic Microbubble Signals for Pressure Estimation
    Flemming Forsberg; Fiscal Year: 2008
    ..This will allow potentially life-threatening diseases, such as increased pressure in the liver, to be diagnosed early. [unreadable] [unreadable] [unreadable]..
  12. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
    ..abstract_text> ..
  13. Novel MRI Contrast Agent for Monitoring Thermal Ablation
    Nathan Mcdannold; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
    ..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
  15. Activation of clotting & cell adhesion: gas embolism
    David M Eckmann; Fiscal Year: 2010
    ..This work is the basis for neuroprotection in gas embolism-induced stroke, a persistent, growing health threat without treatment. ..
  16. Combined Therapeutic-Imaging Agent for Atherosclerosis
    Gregory Lanza; Fiscal Year: 2007
    ..This novel application of molecular imaging and targeted drug delivery could serve as part of a primary prevention strategy to diagnose, treat, and monitor early atherosclerosis. [unreadable] [unreadable] [unreadable]..
  17. COLLOIDAL IRON-OXIDE NANOBEACONS FOR THERANOSTIC USE IN ATHEROSCLEROSIS
    Gregory M Lanza; Fiscal Year: 2010
    ..Demonstrate image-guided drug delivery of antiangiogenic therapy potential with ligand-targeted non-gadolinium nanoplatform in vivo. ..
  18. Community Exposure to Perfluorooctanate
    Edward Emmett; Fiscal Year: 2006
    ..Outcome measures to be evaluated include the reduction of levels of blood C8, and whether community trust is restored through an independent participatory study. ..
  19. PF-L-DOPA: a MRI tool for developmental neurobiology
    Sherry Dingman; Fiscal Year: 2005
    ..This new MRI methods will reveal structural and functional brain alterations during development, making it possible to monitor the neurobiological impact of exposure to drugs. ..
  20. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  21. Repiratory Health and Community Asbestos Exposure
    Bruce Alexander; Fiscal Year: 2007
    ..Analyses will consider cumulative exposure and short, intense periods of exposure, with specific reference to exposure in childhood. ..
  22. Oxygen Carriers for Hypovolemic Circulatory Collapse
    Robert Winslow; Fiscal Year: 2007
    ..The research described in this proposal will focus on molecules and formulations specifically tailored for use in prehospital and trauma settings. ..
  23. CHF TRIAL INVESTIGATING OUTCOMES OF EXERCISE TRAINING
    Dalane Kitzman; Fiscal Year: 2007
    ..abstract_text> ..
  24. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Y Rapoport; Fiscal Year: 2010
    ....
  25. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  26. Ultrasound contrast agent enhances ultarsound assisted thrombolysis in stroke
    Azita Soltani; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  27. Hormonal Opioids in Ischemic Preconditioning
    Eric Dickson; Fiscal Year: 2005
    ..Dickson with the facilities, equipment and expertise necessary to achieve the goals set forth in this proposal...
  28. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  29. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  30. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  31. EXERCISE INTOLERANCE IN ELDERLY DIASTOLIC HEART FAILURE
    Dalane Kitzman; Fiscal Year: 2004
    ..abstract_text> ..
  32. Development of a Novel Gas Embolotherapy Technique
    JOSEPH BULL; Fiscal Year: 2005
    ..The proposed research is an essential first step in developing this potentially revolutionary technique. ..
  33. ACOUSTICALLY ACTIVATED MICELLAR DRUG DELIVERY
    Natalya Rapoport; Fiscal Year: 2001
    ....
  34. ULTRASOUND THERAPY DELIVERY THROUGH INTACT SKULL
    Kullervo Hynynen; Fiscal Year: 2002
    ..A successful implementation of even one of these possible therapies to routing clinical practice could have a major impact on patient care. ..
  35. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    ....
  36. Phased Array Ultrasound System for Cardiac Ablation
    Kullervo Hynynen; Fiscal Year: 2006
    ..This could result in significant cost savings and lead to a cure of thousands of patients. ..
  37. Anthrax DNA vaccine for non-invasive immunization on skin
    Zhengrong Cui; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Quantification of Blood Volume Flow Using Ultrasound
    JEFFREY B FOWLKES; Fiscal Year: 2010
    ....
  39. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2008
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..
  40. STRATEGIES TO LIMIT DEFIBRILLATION AND REPERFUSION INJUR
    Richard Kerber; Fiscal Year: 2002
    ..abstract_text> ..
  41. Preventing Resuscitation Injury and Improving Outcomes
    Richard Kerber; Fiscal Year: 2005
    ..More effective treatment of resuscitation-induced cardiac and brain injury is imperative for improved survival of the estimated 300,000 US victims of cardiac arrest every year. ..
  42. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
    ..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
  43. Health Effects of Lifetime Exposure to Food Contaminants
    Philippe Grandjean; Fiscal Year: 2009
    ..The results may therefore provide new information that could very likely have an impact on the preventive efforts and standard-setting of the EPA and other regulatory agencies in the U.S and elsewhere. ..
  44. Near infrared/MR system for imaging brain oxygenation
    Jeffrey Dunn; Fiscal Year: 2002
    ..This grant will produce a novel imaging modality which can non-invasively monitor cerebral oxygenation, structure, and blood flow. ..
  45. Opening of the Blood Brain Barrier for Molecular Imaging
    Kullervo Hynynen; Fiscal Year: 2007
    ..The development of even one such imaging method for routine clinical use would have a major impact on patient care. [unreadable] [unreadable]..
  46. Chiral separations using fluorous triphasic chemistry
    MARVIN YU; Fiscal Year: 2004
    ..2) To demonstrate a chiral separation in a fluorous triphasic reaction without pre-tagging. 3) To demonstrate that a fluorous triphasic reaction can be used in the formal synthesis of a single enantiomer pharmaceutical. ..
  47. Local harmonic motion imaging for thermal surgery
    Kullervo Hynynen; Fiscal Year: 2006
    ..Therefore the potential clinical impact of the proposed research is significant. ..
  48. ANESTHETIC EFFECTS ON SENSORIMOTOR INTEGRATION
    JOSEPH ANTOGNINI; Fiscal Year: 2009
    ..Understanding how and where anesthetics act will eventually lead to the development of better and safer anesthetics, thereby decreasing peri-operative morbidity and mortality and improving public health. ..
  49. Microbubbles: a novel treatment for hemorrhagic shock
    CLAS LUNDGREN; Fiscal Year: 2007
    ..The project is expected to bring the DDFPe treatment to a state of scientific underpinning and applicability in the animal model which lays a solid foundation for pursuing FDA approval for human use. ..
  50. Sonothrombolysis of Vascular Clots with Targeted Bubbles
    Evan Unger; Fiscal Year: 2007
    ..Furthermore, ultrasound mediated therapies will provide affordable treatments that can be used in small hospitals and emergency rooms where expensive treatment is prohibitive. ..
  51. Ischemia Reperfusion Injury in the Diabetic Heart
    Paul McDonagh; Fiscal Year: 2007
    ..The results will improve our understanding of the role of chronic and acute inflammation in I/R injury in the diabetic heart and suggest new, thoughtful approaches to treat this growing problem. [unreadable] [unreadable]..
  52. High Intensity Ultrasound in Gastroenterology
    JOO HWANG; Fiscal Year: 2003
    ..It is anticipated that this work will help to gain a better understanding of the mechanisms of HIFU and its potential role for other GI applications such as tumor therapy. ..
  53. A Temporal-Spatial Analysis of Breast Cancer in Upper C*
    Veronica Vieira; Fiscal Year: 2006
    ..By learning where breast cancer "hot spots" are and if they grow, intensify, or move over time, researchers will have a better understanding of how environmental risk factors may be involved. ..
  54. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Blood Flow in Small Animals by Ultrasound
    Chandra Sehgal; Fiscal Year: 2006
    ..abstract_text> ..
  56. Doppler Vascularity/Sonography--Breast Cancer Diagnosis
    Chandra Sehgal; Fiscal Year: 2005
    ..An integrated approach in which one mode represents tissue property and the other its function will result in a systematic and comprehensive diagnosis of breast cancers. ..
  57. Flow-mediated dilation by ultrasound imaging
    Chandra Sehgal; Fiscal Year: 2006
    ....