fluorinated hydrocarbons

Summary

Top Publications

  1. ncbi Equivalent asthma control and systemic safety of inhaled budesonide delivered via HFA-134a or CFC propellant in a broad range of doses
    I Grzelewska-Rzymowska
    Clinic of Phtisiopneumonology, Medical University of Lodz, Poland
    Respir Med 97:S10-9. 2003
  2. pmc Copper-free click chemistry for dynamic in vivo imaging
    Jeremy M Baskin
    Department of Chemistry, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:16793-7. 2007
  3. ncbi Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone : a cross-over study in healthy volunteers
    Chet L Leach
    3M Pharmaceuticals, St Paul, MN, USA
    Chest 122:510-6. 2002
  4. ncbi Fluorine in medicinal chemistry
    Sophie Purser
    The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA
    Chem Soc Rev 37:320-30. 2008
  5. ncbi Comparison of the aerosol velocity and spray duration of Respimat Soft Mist inhaler and pressurized metered dose inhalers
    Dieter Hochrainer
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    J Aerosol Med 18:273-82. 2005
  6. ncbi Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 123:2083-8. 2003
  7. ncbi T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR
    Nico Mitro
    The Genomics Institute of the Novartis Research Foundation, San Diego, CA 92037, USA
    FEBS Lett 581:1721-6. 2007
  8. ncbi On the role of liver X receptors in lipid accumulation in adipocytes
    Lene K Juvet
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    Mol Endocrinol 17:172-82. 2003
  9. ncbi The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:4079-88. 2005
  10. ncbi Poly(fluoroalkyl acrylate)-bound ruthenium carbene complex: a fluorous and recyclable catalyst for ring-closing olefin metathesis
    Qingwei Yao
    Department of Chemistry and Biochemistry, The Michael Faraday Laboratories, Northern Illinois University, DeKalb, Illinois 60115, USA
    J Am Chem Soc 126:74-5. 2004

Research Grants

  1. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
  2. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
  3. DOES HYPOXIA PREDICT RADIATION/SURGICAL TUMOR RESPONSE?
    Sydney Evans; Fiscal Year: 2005
  4. Microenvironment: Imaging/Implications in Brain Tumors
    Sydney Evans; Fiscal Year: 2008
  5. Evaluation of Hypoxia by EF5 Binding in Cervix Cancer
    Sydney Evans; Fiscal Year: 2003
  6. Assessment of Hypoxia in Malignant Gliomas Using EF5
    Sydney Evans; Fiscal Year: 2002
  7. Oxidative Damage to DNA Repair Pathways
    Cameron Koch; Fiscal Year: 2006
  8. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
  9. Predicting Radiation Response by Tumor pO2
    Cameron Koch; Fiscal Year: 2006
  10. Purchase of a 600 MHz NMR Spectrometer with Cryoprobe
    DENNIS CURRAN; Fiscal Year: 2007

Detail Information

Publications206 found, 100 shown here

  1. ncbi Equivalent asthma control and systemic safety of inhaled budesonide delivered via HFA-134a or CFC propellant in a broad range of doses
    I Grzelewska-Rzymowska
    Clinic of Phtisiopneumonology, Medical University of Lodz, Poland
    Respir Med 97:S10-9. 2003
    ..The use of the new propellant did not modify the safety profile of inhaled budesonide...
  2. pmc Copper-free click chemistry for dynamic in vivo imaging
    Jeremy M Baskin
    Department of Chemistry, and Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 104:16793-7. 2007
    ..With this technique, we studied the dynamics of glycan trafficking and identified a population of sialoglycoconjugates with unexpectedly rapid internalization kinetics...
  3. ncbi Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone : a cross-over study in healthy volunteers
    Chet L Leach
    3M Pharmaceuticals, St Paul, MN, USA
    Chest 122:510-6. 2002
    ..To compare the lung deposition of radiolabeled hydrofluoroalkane-134a beclomethasone dipropionate (HFA-BDP) with chlorofluorocarbon fluticasone propionate (CFC-FP) and chlorofluorocarbon beclomethasone (CFC-BDP)...
  4. ncbi Fluorine in medicinal chemistry
    Sophie Purser
    The Chemistry Research Laboratory, 12 Mansfield Road, Oxford, UK OX1 3TA
    Chem Soc Rev 37:320-30. 2008
    ..This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency...
  5. ncbi Comparison of the aerosol velocity and spray duration of Respimat Soft Mist inhaler and pressurized metered dose inhalers
    Dieter Hochrainer
    Boehringer Ingelheim Pharma GmbH and Co KG, Ingelheim, Germany
    J Aerosol Med 18:273-82. 2005
    ..5 sec; pMDIs, 0.15-0.36 sec). These characteristics should result in improved lung and reduced oropharyngeal deposition, and are likely to simplify coordination of inhaler actuation and inhalation compared with pMDIs...
  6. ncbi Extra-fine particles improve lung delivery of inhaled steroids in infants: a study in an upper airway model
    Hettie M Janssens
    Department of Pediatrics, Division of Respiratory Medicine, Sophia Childrens Hospital Erasmus Medical Center, Rotterdam, The Netherlands
    Chest 123:2083-8. 2003
    ..Aim: To compare the dose delivered to the lungs of HFA-BDP and CFC-BDP at different breathing patterns using an upper airway model of an infant...
  7. ncbi T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR
    Nico Mitro
    The Genomics Institute of the Novartis Research Foundation, San Diego, CA 92037, USA
    FEBS Lett 581:1721-6. 2007
    ..Since T0901317 has been widely used in animals to study LXR function, the in vivo effects of this compound ascribed to LXR activation should be re-examined...
  8. ncbi On the role of liver X receptors in lipid accumulation in adipocytes
    Lene K Juvet
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    Mol Endocrinol 17:172-82. 2003
    ..These findings imply a role for LXR in controlling lipid storage capacity in mature adipocytes and point to an intriguing physiological interplay between LXR and PPARgamma in controlling pathways in lipid handling...
  9. ncbi The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease
    Radosveta P Koldamova
    Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Biol Chem 280:4079-88. 2005
    ..Our experiments demonstrate that T0901317 decreases amyloidogenic processing of APP in vitro and in vivo, thus supporting the search for potent and specific LXR ligands with properties allowing therapeutic application...
  10. ncbi Poly(fluoroalkyl acrylate)-bound ruthenium carbene complex: a fluorous and recyclable catalyst for ring-closing olefin metathesis
    Qingwei Yao
    Department of Chemistry and Biochemistry, The Michael Faraday Laboratories, Northern Illinois University, DeKalb, Illinois 60115, USA
    J Am Chem Soc 126:74-5. 2004
    ..The practical advantage offered by the fluorous catalyst is demonstrated by its sequential use in up to five different metathesis reactions...
  11. ncbi Effect of trifluoroacetate, a persistent degradation product of fluorinated hydrocarbons, on Phaseolus vulgaris and Zea mays
    Martin F Smit
    School of Environmental Sciences and Development, Potchefstroom Campus, North West University, Potchefstroom 2520, North West Province, South Africa
    Plant Physiol Biochem 47:623-34. 2009
    ....
  12. pmc Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense
    Kathleen Smoak
    Laboratory of Respiratory Biology, Department of Health and Human Services, Cellular and Molecular Pathology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    J Immunol 180:3305-12. 2008
    ..Taken together, these data define a novel role for LXR in lung pathophysiology and neutrophil biology and identify pharmacologic activation of LXR as a potential tool for modulation of innate immunity in the lung...
  13. ncbi The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR
    Ji Young Cha
    Department of Physiology, Touchstone Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 282:743-51. 2007
    ..This establishes LXR as a master lipogenic transcription factor, as it directly regulates both SREBP-1c and ChREBP to enhance hepatic fatty acid synthesis...
  14. ncbi Synthesis of a muscarinic receptor antagonist via a diastereoselective Michael reaction, selective deoxyfluorination and aromatic metal-halogen exchange reaction
    T Mase
    Process R and D, Laboratories for Technology Development, Banyu Pharmaceutical Co Ltd, Kamimutsuna 3 Chome 9 1, Okazaki, Aichi 444 0858, Japan
    J Org Chem 66:6775-86. 2001
    ..Finally, the highly convergent synthesis of 1 was accomplished by coupling of the two fragments. This synthesis has been used to prepare multi-kilogram quantities of the bulk drug...
  15. pmc Aminodifluorosulfinium tetrafluoroborate salts as stable and crystalline deoxofluorinating reagents
    Francis Beaulieu
    OmegaChem Inc, 8800 Boul De la Rive Sud, Levis, QC G6V 9H1, Canada
    Org Lett 11:5050-3. 2009
    ....
  16. ncbi Direct and convenient conversion of alcohols to fluorides
    Jingjun Yin
    Department of Process Research, Merck Research Laboratories, P O Box 2000, Rahway, New Jersey 07065, USA
    Org Lett 6:1465-8. 2004
    ..The readily available reagents are easy to handle, and the mild, almost neutral reaction conditions allow for excellent functional group compatibility. A NR(3)(HF)(3)/NR(3) ratio of </=1:2 gives the highest reactivity...
  17. ncbi Bronchoprotective and bronchodilator effects of an HFA pMDI vs. a CFC pMDI and a DPI containing formoterol in asthma patients
    S J Langley
    North West Lung Research Centre, Wythenshawe Hospital, Manchester, UK
    Respiration 72:35-7. 2005
    ..In conclusion, Modulite HFA formoterol was found to be an effective and well tolerated treatment in patients with asthma, with comparable efficacy to current formoterol preparations...
  18. ncbi Effects of HFA- and CFC-beclomethasone dipropionate on the bronchial response to methacholine (MCh) in mild asthma
    Claudio Micheletto
    Department of Pneumology, Orlandi General Hospital, 37012 Bussolengo, Verona, Italy
    Respir Med 99:850-5. 2005
    ....
  19. ncbi Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects
    George P Chrousos
    First Department of Pediatrics, Athens University Medical School, Agia Sophia Children s Hospital, 11527 Athens, Greece
    Chest 128:70-7. 2005
    ..The effect of MF-DPI, 400 microg qd, on the HPA axis was compared to that of beclomethasone dipropionate (BDP) using hydrofluoroalkane (HFA) and chlorofluorocarbon (CFC) propellants via metered-dose inhalers (MDIs) twice daily...
  20. ncbi Pharmacokinetic and pharmacodynamic properties of inhaled beclometasone dipropionate delivered via hydrofluoroalkane-containing devices
    Eric Derom
    Department of Respiratory Diseases, Ghent University Hospital, De Pintelaan 185, B 9000 Gent, Belgium
    Clin Pharmacokinet 44:815-36. 2005
    ..Good studies on the bioequivalence between the reference beclometasone dipropionate formulation and the Modulite or Beclazone formulations are not available...
  21. ncbi Development and performance of a new hydrofluoroalkane (HFA 134a)-based metered dose inhaler (MDI) of salmeterol
    I D Peyron
    Inhalation Product Development, GlaxoSmithKline, 23 Rue Lavoisier, Z I no 2, Evreux, 27000, France
    Respir Med 99:S20-30. 2005
    ..0 microg. Comparability in aerosol characteristics was also demonstrated when the salmeterol HFA inhaler was tested using a large volume spacer (Volumatic)...
  22. ncbi Comparative improvement of asthma symptoms and expiratory flows after corticosteroid treatment: a method to assess the effect of corticosteroids on large vs. small airways?
    Louis Philippe Boulet
    Institut de cardiologie et de pneumologie de l Hôpital Laval, 2725 Chemin Sainte Foy, Quebec, QC, Canada G1V 4G5
    Respir Med 100:496-502. 2006
    ..This may suggest that this ratio is not useful for evaluating the effect of corticosteroids on small airways, or that extrafine HFA-BDP acts at the level of large- to moderate-caliber airways to produce most of its beneficial effect...
  23. ncbi HFA inhalers
    J C Koninck
    Pulmonary Medicine Unit, University of Tours, France
    Pediatr Pulmonol Suppl 26:23-5. 2004
  24. ncbi CFC Phase-Out and the Chiesi Solution
    G Huchon
    faculté de médecine Paris 5, Service de Pneumologie et Reanimation, hôpital de l Hôtel dieu, Paris, France
    Respiration 72:1-2. 2005
  25. pmc Hydrofluoroalkane-beclomethasone versus chlorofluorocarbon-beclomethasone delivery in neonatal models
    C H Cole
    The Floating Hospital for Children, Tufts New England Medical Center, Tufts University School of Medicine, Boston, MA, 02111, USA
    Arch Dis Child Fetal Neonatal Ed 89:F417-8. 2004
    ..The delivery of hydrofluoroalkane-beclomethasone was significantly greater in each simulation...
  26. ncbi Comparison of the systemic pharmacodynamic effects and pharmacokinetics of salmeterol delivered by CFC propellant and non-CFC propellant metered dose inhalers in healthy subjects
    Rodger Kempsford
    Clinical Pharmacology and Discovery Medicine, GlaxoSmithKline Research and Development, Greenford Road, Greenford, Middlesex UB6 0HE, UK
    Respir Med 99:S11-9. 2005
    ..These data indicate that the salmeterol HFA MDI would not be associated with a significantly different pharmacodynamic, safety and tolerability profile compared with the salmeterol CFC MDI...
  27. ncbi Salmeterol HFA is as effective as salmeterol CFC in children and adults with persistent asthma
    Narinder Chopra
    GlaxoSmithKline Research and Development, Global Commerical Strategy, Respiratory Building 38, 1 Floor, Greenford Road, Greenford, Middlesex UB6 0HE, UK
    Respir Med 99:S1-S10. 2005
    ..Together these data demonstrate salmeterol HFA MDI to be as effective as salmeterol CFC MDI in adults and children...
  28. ncbi Efficacy and safety of fluticasone propionate/salmeterol HFA 134A MDI in patients with mild-to-moderate persistent asthma
    David S Pearlman
    Colorado Allergy and Asthma Centers, P C, Denver, Colorado 80230, USA
    J Asthma 41:797-806. 2004
    ..g., bronchoconstriction), with FSC results in greater overall improvements in asthma control compared with treatment of either individual component alone...
  29. ncbi Safety and efficacy of HFA-134a beclomethasone dipropionate extra-fine aerosol over six months
    Louis Philippe Boulet
    Institut Universitaire de Cardiologie et de Pneumologie, l Université Laval, Hopital Laval, Sainte Foy, Quebec
    Can Respir J 11:123-30. 2004
    ..To compare the systemic safety and efficacy of hydrofluoroalkane beclomethasone dipropionate (HFA-BDP) extra-fine aerosol 800 microg/day with chlorofluorocarbon (CFC)-BDP 1500 microg/day...
  30. ncbi A comparison of the efficacy and tolerability of single doses of HFA 134a albuterol and CFC albuterol in mild-to-moderate asthmatic patients
    Stephen J Langley
    Medicines Evaluation Unit, North West Lung Research Center, Wythenshawe Hospital, Manchester, United Kingdom
    Ann Allergy Asthma Immunol 88:488-93. 2002
    ..After the signing of the Montreal Protocol in 1987, new propellants for use in pressurized metered-dose inhalers that are non-ozone-depleting have been developed...
  31. ncbi Treatment of exercise-induced asthma with beclomethasone dipropionate in children with asthma
    R Petersen
    Dept of Paediatrics, Kolding Hospital, 6000 Kolding, Denmark
    Eur Respir J 24:932-7. 2004
    ..Further studies are needed to assess whether q.d. administration of beclomethasone dipropionate is as effective as b.i.d. administration...
  32. ncbi Optimizing aerosol delivery by pressurized metered-dose inhalers
    Bruce K Rubin
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 50:1191-200. 2005
    ..In this manuscript we discuss ways to optimize the use of medications given via pMDI and examine recent changes in pMDI technology that will make drug delivery more efficient and consistent...
  33. ncbi The CFC to HFA transition and its impact on pulmonary drug development
    Chet L Leach
    Lovelace Respiratory Research Institute, Albuquerque, New Mexico 87108, USA
    Respir Care 50:1201-8. 2005
    ..The transition from CFCs also spurred novel new drug-delivery technologies, improved dry powder inhalers, and highly dispersible engineered powders...
  34. ncbi Budesonide administered using chlorofluorocarbon and hydrofluoroalkane pressurized metered-dose inhalers: pharmacokinetics, pharmacodynamics and clinical equivalence
    D Singh
    Respiratory Pharmacology, South Manchester University Hospitals Trust, University of Manchester, Manchester, UK
    Int J Clin Pharmacol Ther 45:485-95. 2007
    ..However, there is a need to ensure that pMDIs with these novel propellants are as effective and safe as their older counterparts...
  35. ncbi Albuterol inhalers
    Nicholas J Gross
    N Engl J Med 356:2749; author reply 2749. 2007
  36. ncbi Withdrawal of albuterol inhalers containing chlorofluorocarbon propellants
    Leslie Hendeles
    College of Pharmacy and the Pediatric Pulmonary Division, University of Florida, Gainesville, FL 32610 0486, USA
    N Engl J Med 356:1344-51. 2007
  37. ncbi Efficacy and safety of fluticasone propionate hydrofluoroalkane inhalation aerosol in pre-school-age children with asthma: a randomized, double-blind, placebo-controlled study
    Paul Y Qaqundah
    Pediatric Medical Care Group, Inc, Huntington Beach, CA, USA
    J Pediatr 149:663-670. 2006
    ..To evaluate the efficacy and tolerability of fluticasone propionate (FP) hydrofluoroalkane (HFA) in children age 1 to < 4 years with asthma...
  38. ncbi Pharmacokinetics of beclomethasone dipropionate in an hydrofluoroalkane-134a propellant system in Japanese children with bronchial asthma
    Takahide Teramoto
    Department of Pediatrics, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu, Japan
    Allergol Int 55:317-20. 2006
    ..This is the first report of the pharmacokinetics of beclomethasone dipropionate (BDP) delivered from a pressurized solution formulation using an HFA propellant system (HFA-BDP) in Japanese children with bronchial asthma...
  39. ncbi Efficacy of beclomethasone dipropionate HFA 200 microg once daily in chronic obstructive pulmonary disease and bronchial asthma
    G Tatsis
    Pulmonology Clinic, Evangelismos General Hospital, Athens, Greece
    J Int Med Res 35:361-73. 2007
    ....
  40. ncbi Usefulness of HFA-BDP for adult patients with bronchial asthma: randomized crossover study with fluticasone
    Takahiko Horiguchi
    Department of Respiratory Medicine, Second Teaching Hospital, Fujita Health University School of Medicine, Nagoya, Aichi, Japan
    J Asthma 43:509-12. 2006
    ..05 and < 0.01, respectively) when on HFA-BDP versus fluticasone DPI. HFA-BDP might be delivered to small airways more effectively than fluticasone DPI...
  41. ncbi Clinical comparability between the CFC and HFA budesonide pressurised metered-dose inhalers in paediatric patients with asthma: a randomised controlled trial
    A Escribano
    Unidad de Neumologia Infantil, Servicio de Pediatria, Hospital Clinico Universitario, Universidad de Valencia, Valencia, Spain
    Curr Med Res Opin 22:1085-92. 2006
    ....
  42. ncbi One-year evaluation of the preventative effect of hydrofluoroalkane-beclomethasone dipropionate on eosinophilic inflammation of asthmatic peripheral airways
    Hiroyuki Ohbayashi
    Department of Allergy and Respiratory Medicine, Tohno Kousei Hospital, Mizunami, Gifu Pref 509 6101, Japan
    Respiration 74:146-53. 2007
    ..In asthmatic patients with eosinophilic inflammation of the peripheral airways, appropriate drug delivery to the affected area is required...
  43. ncbi Spray pattern analysis for metered dose inhalers: effect of actuator design
    Hugh Smyth
    College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
    Pharm Res 23:1591-6. 2006
    ..This study was conducted to identify the device factors influencing spray pattern and particle size to gain a more complete understanding of spray plume measurements...
  44. ncbi A comparison of 2 extrafine hydrofluoroalkane-134a-beclomethasone formulations on methacholine hyperresponsiveness
    Tom C Fardon
    Asthma and Allergy Research Group, Division of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    Ann Allergy Asthma Immunol 96:422-30. 2006
    ..Thus, extrafine particle formulations of inhaled corticosteroids are of clinical interest...
  45. pmc Effects of hydrofluoroalkane and dry powder-formulated corticosteroids on sputum inflammatory markers in asthmatic patients
    H Hauber
    Meakins Christie Laboratories, McGill University, Montreal, Canada
    Can Respir J 13:73-8. 2006
    ..Inflammatory characteristics of induced sputum have been shown to differ in samples collected early after sputum induction compared with later...
  46. ncbi Fluticasone propionate hydrofluoroalkane inhalation aerosol in patients receiving inhaled corticosteroids
    William R Lumry
    AARA Research Center, Dallas, TX 75231, USA
    Ann Allergy Asthma Immunol 96:51-9. 2006
    ..Therefore, some metered-dose inhaler products are being reformulated with "ozone-friendly" hydrofluoroalkane propellants...
  47. ncbi Fluticasone propionate HFA-134a pressurized metered-dose inhaler in adolescents and adults with moderate to severe asthma
    Jacob L Pinnas
    University of Arizona School of Medicine, Tucson, Arizona, USA
    J Asthma 42:865-71. 2005
    ..The incidence of adverse events and 24-hour urine cortisol excretion rates were similar between active treatments and placebo...
  48. ncbi Application of USP inlet extensions to the TSI impactor system 3306/3320 using HFA 227 based solution metered dose inhalers
    Erik Mogalian
    College of Pharmacy, University of Arizona, 1703 E Mabel St, Rm 437, Tucson, AZ, USA
    Drug Dev Ind Pharm 31:977-85. 2005
    ..Additionally, the results generated from this study were used to evaluate the product performance of HFA 227 based solution formulations that contain varying concentrations of ethanol as a cosolvent...
  49. ncbi Propellant-driven metered-dose inhalers for pulmonary drug delivery
    Hugh D C Smyth
    University of North Carolina at Chapel Hill, School of Pharmacy, NC 27599, USA
    Expert Opin Drug Deliv 2:53-74. 2005
    ..The ability to succeed in these areas will be largely determined by the willingness to invest in fundamental research of pMDI technologies...
  50. ncbi Pharmacodynamic equivalence study of CFC-free and CFC-containing procaterol hydrochloride metered-dose inhalers
    M Kawai
    Department of Respiratory Disease, Kouseikai Takaori Hospital Medical Corporation, Sakyo ku, Kyoto, Japan
    Methods Find Exp Clin Pharmacol 27:555-8. 2005
    ..0507 to 0.0039 (L) for mean AUC (FEV1)/h and -0.056 to 0.026 (L) for mean peak FEV1, both within the acceptance criteria of -0.15 to 0.15 (L). Meptin [HFA] was therefore assessed as being equivalent to the current Meptin [CFC]...
  51. ncbi Part III: Location of asthma inflammation and the distal airways: clinical implications
    Monica Kraft
    Duke Asthma, Allergy, and Airway Center, Duke University, Durham, NC 27710, USA
    Curr Med Res Opin 23:S21-7. 2007
    ..Due to their highly targeted delivery systems, newer HFA-based formulations have the potential to effectively treat asthma at reduced doses...
  52. ncbi Aerosol therapy: assume nothing and require data
    Paula J Anderson
    Respir Care 48:1016-8. 2003
  53. ncbi In vitro performance of two common valved holding chambers with a chlorofluorocarbon-free beclomethasone metered-dose inhaler
    Michael J Asmus
    Department of Pharmacy Practice, College of Pharmacy, University of Florida, Gainesville 32610 0486, USA
    Pharmacotherapy 23:1538-44. 2003
    ....
  54. ncbi Clinical studies in asthmatics with a new non-extra fine HFA formulation of beclometasone dipropionate (BDP Modulite)
    J Bousquet
    Hopital Arnaud de Villeneuve, Montpellier, France
    Respir Med 96:S17-27. 2002
    ..In conclusion, the results of the clinical studies with BDP Modulite show that this new HFA formulation allows a seamless transition to CFC-free BDP, thus simplifying the changeover...
  55. ncbi Modulite technology: pharmacodynamic and pharmacokinetic implications
    A Woodcock
    North West Lung Research Centre, Manchester, U K
    Respir Med 96:S9-15. 2002
    ..Plasma profile of BDP and B17MP were similar after inhalation from BDP Modulite with standard actuator or delivered via a spacer, suggesting that pulmonary delivery of BDP to the lung is similar with both actuators...
  56. ncbi Balancing ethanol cosolvent concentration with product performance in 134a-based pressurized metered dose inhalers
    Abhishek Gupta
    College of Pharmacy, University of Arizona, Tucson 85721, USA
    J Aerosol Med 16:167-74. 2003
    ..This study illustrates the importance of considering both formulation properties and product performance characteristics when optimizing a metered dose inhaler drug delivery system...
  57. ncbi Therapeutic ratio of hydrofluoroalkane and chlorofluorocarbon formulations of fluticasone propionate
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Chest 122:618-23. 2002
    ..To compare the therapeutic ratio of chlorofluorocarbon (CFC) and hydrofluoroalkane-134a (HFA) formulations of fluticasone propionate (FP)...
  58. ncbi A neglected breakthrough in asthma therapy
    H Morrow Brown
    Lancet 361:433-4. 2003
  59. ncbi Local versus total systemic bioavailability of beclomethasone dipropionate CFC and HFA metered dose inhaler formulations
    Lester I Harrison
    3M Pharmaceuticals, St Paul, Minnesota 55144, USA
    J Aerosol Med 15:401-6. 2002
    ..It is recommended that this parameter be considered whenever deposition and pharmacokinetic data for two formulations of the same inhaled substance are compared...
  60. ncbi Effects on lung function, symptoms, and bronchial hyperreactivity of low-dose inhaled beclomethasone dipropionate given with HFA-134a or CFC propellant
    A Woodcock
    North West Lung Centre, Wythenshawe Hospital, Manchester, UK
    J Aerosol Med 15:407-14. 2002
    ..Further studies are needed using higher doses in moderate to severe asthma to confirm these preliminary findings...
  61. ncbi Switching from conventional to extrafine aerosol beclomethasone dipropionate therapy in children: a 6-month, open- label, randomized trial
    Stanley J Szefler
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 110:45-50. 2002
    ..In adults with asthma, hydrofluoralkane-134a beclomethasone dipropionate (HFA-BDP) extrafine aerosol provides equivalent asthma control at half the daily dose of conventional chlorofluorocarbon (CFC)-BDP...
  62. ncbi Growth, systemic safety, and efficacy during 1 year of asthma treatment with different beclomethasone dipropionate formulations: an open-label, randomized comparison of extrafine and conventional aerosols in children
    Søren Pedersen
    paediatrisk afdeling, Kolding Sygehus, Kolding, Denmark
    Pediatrics 109:e92. 2002
    ....
  63. ncbi Efficacy of HFA-beclomethasone dipropionate extra-fine aerosol (800 microg day(-1)) versus HFA-fluticasone propionate (1000 microg day(-1)) in patients with asthma
    M Aubier
    Service de Pneumologie, H pital Bichat, Paris, France
    Respir Med 95:212-20. 2001
    ..In conclusion, this study showed that, in patients with moderate-to-severe symptomatic asthma, HFA-BDP extra-fine aerosol 800 microg(-1) was at least as effective and equally well tolerated as 1000 microg day(-1) HFA-FP...
  64. ncbi Hydrofluoroalkane-134a beclomethasone as a dominant economic asthma therapy
    D C Malone
    Center for Health Outcomes and PharmacoEconomic Research, College of Pharmacy, University of Arizona Health Sciences Center, 1703 E Mabel Street, Tucson, AZ 85721 0207, USA
    Respir Med 97:1269-76. 2003
    ..The median incremental cost-effectiveness ratio was dollars -5.77 (95% CI: dollars -68.08 to dollars -4.08). The results of this analysis indicate that HFA-BDP was a dominant therapy (more effective, less costly) compared to CFC-BDP...
  65. ncbi The delivery of chlorofluorocarbon-propelled versus hydrofluoroalkane-propelled beclomethasone dipropionate aerosol to the mechanically ventilated patient: a laboratory study
    Jolyon P Mitchell
    Trudell Medical International, London, Ontario, Canada
    Respir Care 48:1025-32. 2003
    ....
  66. ncbi Efficacy response of inhaled HFA-albuterol delivered via the breath-actuated Autohaler inhalation device is comparable to dose in patients with asthma
    Gary Gross
    Pharmaceutical Research and Consulting, Dallas, Texas 75231, USA
    J Asthma 40:487-95. 2003
    ....
  67. ncbi Step-down therapy with low-dose fluticasone-salmeterol combination or medium-dose hydrofluoroalkane 134a-beclomethasone alone
    Stephen J Fowler
    Asthma and Allergy Research Group, Department of Clinical Pharmacology and Therapeutic, Ninewells Hospital and Medical School, University of Dundee, Dundee, Scotland
    J Allergy Clin Immunol 109:929-35. 2002
    ..Options for step-down therapy include use of inhaled corticosteroids alone or in combination with a long-acting beta2-agonist...
  68. ncbi A new HFA-134a propellant in the administration of inhaled BDP via the Jet spacer: controlled clinical trial vs the conventional CFC
    V Vondra
    Pneumology Department, Prague, Czech Republic
    Respir Med 96:784-9. 2002
    ..In conclusion, the BDP-HFA-134a formulation proved to be equivalent in efficacy and comparable in safety to the standard BDP-CFC product over 12 weeks in adult patients with mild-to-moderate persistent asthma...
  69. ncbi Factors affecting the efficiency of aerosol therapy with pressurised metered-dose inhalers through plastic spacers
    A A Chuffart
    Department of Respiratory Medicine, University Children's Hospital, , Switzerland
    Swiss Med Wkly 131:14-8. 2001
    ..Using an optimal pMDI/spacer combination leads to a significantly improved bronchodilator response...
  70. ncbi Perfluorooctanesulfonate and related fluorinated hydrocarbons in marine mammals, fishes, and birds from coasts of the Baltic and the Mediterranean Seas
    Kurunthachalam Kannan
    National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 36:3210-6. 2002
    ..PFOS is a widespread contaminant in wildlife from the Baltic and the Mediterranean Seas, while FOSA and PFOA were detected only in certain locations indicating their sporadic spatial distribution...
  71. ncbi Attenuation of methane and volatile organic compounds in landfill soil covers
    Charlotte Scheutz
    Environment and Resources, Bygningstorvet Building 115, Technical University of Denmark, DK 2800 Lyngby, Denmark
    J Environ Qual 33:61-71. 2004
    ..In total, 26 VOCs were investigated, including chlorinated methanes, ethanes, ethenes, fluorinated hydrocarbons, and aromatic hydrocarbons...
  72. ncbi Occupational exposure to fluorinated hydrocarbons during refrigeration repair work
    Merete Gjølstad
    National Institute of Occupational Health, PO Box 8149 Dep, N 0033 Oslo, Norway
    J Environ Monit 5:236-40. 2003
    ..Phosgene was not detected. A large number of VOCs in various concentrations were found during welding. Except for the applied refrigerants, halogenated compounds were only found in one sample...
  73. ncbi Computer simulations of propofol infusions for total intravenous anaesthesia in dogs
    K E Joubert
    Veterinary Anaesthesia, Analgesia and Critical Care Services, PO Box 1898, Lonehill, 2062 South Africa
    J S Afr Vet Assoc 80:2-9. 2009
    ..The agents desflurane and sevoflurane are fluorinated hydrocarbons and act as greenhouse gases...
  74. ncbi Perfluorooctanesulfonate and related fluorinated hydrocarbons in mink and river otters from the United States
    Kurunthachalam Kannan
    National Food Safety and Toxicology Center, Department of Zoology, Institute of Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 36:2566-71. 2002
    ..PFOS was detected in livers of all river otters collected from Washington and Oregon at concentrations ranging from 25 to 994 ng/g, wet wt...
  75. ncbi Hydrofluoric acid burn in a child from a compressed air duster
    Claudia Moreno
    Department of Surgery, University of Florida, Gainesville, Florida 32610 0286, USA
    J Burn Care Res 28:909-12. 2007
    Abuse of fluorinated hydrocarbons is on the rise, especially among the adolescent population. These products are potentially hazardous and pose substantial risks when abused...
  76. ncbi Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine
    Ilona Mucsi
    Department of Medical Microbiology, Faculty of General Medicine, University of Szeged, Hungary
    Anticancer Res 22:2833-6. 2002
    ..The resistance modifier compounds alone also induced apoptosis and it was slightly higher in the parent cells than its MDR1/A gene-transformed subline...
  77. ncbi Special applications of fluorinated organic compounds
    Grzegorz Lewandowski
    Institute of Chemical Organic Technology, Szczecin University of Technology, Pl 70 322 Szczecin, Pułaskiego 10, Poland
    J Hazard Mater 136:385-91. 2006
    ..Recent achievements in methods of the fluorination and general principles of the synthesis of useful perfluorinated organic compounds are given as well...
  78. ncbi Role of cytochrome P4503A in cysteine S-conjugates sulfoxidation and the nephrotoxicity of the sevoflurane degradation product fluoromethyl-2,2-difluoro-1-(trifluoromethyl)vinyl ether (compound A) in rats
    Pam Sheffels
    Department of Anesthesiology, University of Washington, Seattle, Washington 98195 6540, USA
    Chem Res Toxicol 17:1177-89. 2004
    ..FDVE S-conjugates sulfoxidation constitutes a newly discovered mechanism of FDVE bioactivation and toxicification in rats, in addition to beta-lyase-catalyzed metabolism of FDVE-cysteine S-conjugates...
  79. ncbi Oxygen therapeutics--current concepts
    S E Hill
    Department of Anesthesiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Can J Anaesth 48:S32-40. 2001
    ..These oxygen transport agents can be divided into two main groups, perfluorocarbon (PFC) emulsions and modified hemoglobin solutions...
  80. ncbi Cytosolic heat shock proteins and heme oxygenase-1 are preferentially induced in response to specific and localized intramitochondrial damage by tetrafluoroethylcysteine
    Han K Ho
    Department of Medicinal Chemistry, University of Washington, Box 357610, Seattle, WA 98195, USA
    Biochem Pharmacol 72:80-90. 2006
    ..The cytoprotective effects of such HSP responses suggest a plausible role in modulating the progression of TFEC-induced cellular injury...
  81. ncbi A cobalt(II) hexafluoroacetylacetonate ethylenediamine complex as a CVD molecular source of cobalt oxide nanostructures
    Giuliano Bandoli
    Department of Pharmaceutical Sciences, Padova University, 35131 Padova, Italy
    Inorg Chem 48:82-9. 2009
    ..Preliminary chemical vapor deposition (CVD) experiments highlight its very promising features as a CVD/atomic layer deposition molecular source for cobalt oxide nanosystems...
  82. ncbi Syntheses, structures and photophysical properties of heterotrinuclear Zn2Ln clusters (Ln = Nd, Eu, Tb, Er, Yb)
    Hai Bing Xu
    MOE Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou, 510275, China
    Dalton Trans 39:5676-82. 2010
    ..By virtue of the dual luminescence with complementary colours, the Znq(2)-based cyan emission and Eu(III)-centred red luminescence are combined to generate a white-light emission in the Zn(2)Eu (3) complex...
  83. ncbi Synthesis and evaluation of 2-(2-fluoro-4-hydroxymethyl-5-methoxy-phenoxy)acetic acid as a linker in solid-phase synthesis monitored by gel-phase (19)F NMR spectroscopy
    Fredrik K Wallner
    Department of Chemistry, Umea University, SE 90187 Umea, Sweden
    Org Biomol Chem 5:2464-71. 2007
    ..Direct glycosylation of the linker itself followed by mild acidic cleavage gave a fully protected hemiacetal for further chemical manipulation...
  84. ncbi Evaluation of the temperature of different refrigerant sprays used as a pulpal test
    Carlos Alberto Herrero de Morais
    Department of Dentistry, Maringá State University UEM, Maringa, PR, Brazil
    Aust Endod J 34:86-8. 2008
    ..Results indicate that Endo-Ice and Endo-Frost presented the lowest temperatures among the refrigerant sprays tested. Temperatures measured inside the pulp chamber, however, were statistically similar in all groups...
  85. ncbi Atmospheric chemistry of HFE-7000 (CF(3)CF (2)CF (2)OCH (3)) and 2,2,3,3,4,4,4-heptafluoro-1-butanol (CF (3)CF (2)CF (2)CH (2)OH): kinetic rate coefficients and temperature dependence of reactions with chlorine atoms
    Yolanda Díaz-de-Mera
    Facultad Químicas, Departamento Quimica Fisica, Universidad de Castilla La Mancha, Avda Camilo Jose Cela 10, E 13071, Ciudad Real, Spain
    Environ Sci Pollut Res Int 15:584-91. 2008
    ..In the present work, we report the results obtained in the study of the reactions of Cl radicals with HFE-7000 (CF(3)CF(2)CF(2)OCH(3)) (1) and its isomer CF(3)CF(2)CF(2)CH(2)OH (2)...
  86. ncbi A facile synthesis of C-24 and C-25 oxysterols by in situ generated ethyl(trifluoromethyl)dioxirane
    Shoujiro Ogawa
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya, Tokyo 156 8550, Japan
    Steroids 74:81-7. 2009
    ..e., 25-hydroxycholesterol, as well as its 3-sulfate (overall yield of the sulfate, 24%) and 24-oxocholesterol (16%), starting from cholesterol...
  87. ncbi The effect of hexafluorocyclobutene on rat bronchoalveolar lavage fluid surfactant phospholipids and alveolar type II cells
    B Jugg
    Biomedical Sciences Department, Chemical and Biological Defence Sector, Salisbury, Wiltshire, UK
    Hum Exp Toxicol 20:267-76. 2001
    ..These differences suggest different mechanisms of action even though pulmonary oedema is the final injury for all gases. Better knowledge of the mechanisms involved will improve prospects for prophylactic/therapeutic intervention...
  88. ncbi Switching from Ventolin CFC to Ventolin HFA is well tolerated and effective in patients with asthma
    W Lumry
    AARA Research Center, Dallas, TX 75231, USA
    Ann Allergy Asthma Immunol 86:297-303. 2001
    ..Environmental imperatives to eliminate the use of chlorofluorocarbon (CFC) propellants in metered-dose inhalers have led to the development of metered-dose inhalers with the hydrofluoroalkane (HFA-134a) propellants...
  89. ncbi ortho-Selective phenol-coupling reaction by anodic treatment on boron-doped diamond electrode using fluorinated alcohols
    Axel Kirste
    Rheinische Friedrich Wilhelms Universitat Bonn, Kekule Institut fur Organische Chemie und Biochemie, Gerhard Domagk Strasse 1, 53121 Bonn, Germany
    Chemistry 15:2273-7. 2009
    ..At partial conversion, a clean transformation is achieved that can be applied to electron-rich as well as fluorinated phenols...
  90. ncbi Only carbon dioxide absorbents free of both NaOH and KOH do not generate compound A during in vitro closed-system sevoflurane: evaluation of five absorbents
    L F Versichelen
    Department of Anesthesia, Ghent University Hospital, Belgium
    Anesthesiology 95:750-5. 2001
    ..Insufficient data exist on the production of compound A during closed-system sevoflurane administration with newer carbon dioxide absorbents...
  91. ncbi Iridium-catalyzed reactions of trifluoromethylated compounds with alkenes: a C(sp3)-H bond activation alpha to the trifluoromethyl group
    Yong Guo
    Department of Chemistry, Okayama University of Science, 1 1, Ridai cho, Okayama 700 0005, Japan
    Angew Chem Int Ed Engl 48:2047-9. 2009
    ..This atom-economical reaction occurs under neutral reaction conditions and without the formation of undesired defluorinated by-products, even at high temperature...
  92. ncbi Global analysis of nuclear receptor expression and dysregulation in human osteoarthritic articular cartilage: reduced LXR signaling contributes to catabolic metabolism typical of osteoarthritis
    L A Collins-Racie
    Department of Biological Technologies, Cambridge, MA 02140, USA
    Osteoarthritis Cartilage 17:832-42. 2009
    ..Compare the expression and regulation of nuclear receptors (NRs) in osteoarthritic and normal human articular cartilage...
  93. ncbi Synthesis of 3'-deoxynucleosides with 2-oxabicyclo[3.1.0]hexane sugar moieties: addition of difluorocarbene to a 3',4'-unsaturated uridine derivative and 1,2-dihydrofurans derived from D- and L-xylose1
    Ireneusz Nowak
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602 5700, USA
    J Org Chem 72:3319-25. 2007
    ..Removal of base- and sugar-protecting groups gave new difluoromethylene-bridged nucleoside analogues...
  94. ncbi A-band methyl halide dissociation via electronic curve crossing as studied by electron energy loss spectroscopy
    H Kato
    Department of Physics, Sophia University, Tokyo 102 8554, Japan
    J Chem Phys 133:054304. 2010
    ..The effect of electronic-state curve crossing emerged in the transition probabilities for the (3)Q(0) and (1)Q(1) states, with spin-orbit splitting observed and quantified against results from recent ab initio studies...
  95. ncbi Addition of difluorocarbene to 3',4'-unsaturated nucleosides: synthesis of 2'-deoxy analogues with a 2-oxabicyclo[3.1.0]hexane framework
    Ireneusz Nowak
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602 5700, USA
    J Org Chem 72:532-7. 2007
    ..The solid-state conformation of the nearly planar furanosyl ring in the uracil compound had a shallow 2E pucker, and a more pronounced 1E conformation was present in the furanosyl ring of the cytosine derivative...
  96. ncbi Surface modification of an experimental silicone rubber aimed at reducing initial candidal adhesion
    C Price
    Department of Dental Health and Biological Sciences, Dental School, University of Wales College of Medicine, Heath Park, Cardiff CF14 4XY UK
    J Biomed Mater Res 63:122-8. 2002
    ..In conclusion, silane surface treatment of an experimental silicone rubber has been successful in reducing candidal adherence...
  97. ncbi Temporal trends of polyfluoroalkyl compounds in harbor seals (Phoca vitulina) from the German Bight, 1999-2008
    Lutz Ahrens
    GKSS Research Centre Geesthacht, Department for Environmental Chemistry, Institute for Coastal Research, DE 21502 Geesthacht, Germany
    Chemosphere 76:151-8. 2009
    ..070), the high concentrations of PFOS and constant levels of C(9)-C(13) PFCAs indicates that further work on the reduction of environmental emissions of PFCs are necessary...
  98. ncbi Ring-fluorinated isoquinoline and quinoline synthesis: intramolecular cyclization of o-cyano- and o-isocyano-beta,beta-difluorostyrenes
    Junji Ichikawa
    Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Org Lett 5:1455-8. 2003
    ..Subsequent cyclization via substitution of the fluorine leads to 3-fluoroquinolines. [reaction: see text]..
  99. ncbi Methodology for characterizing heat removal mechanism in human skin during cryogen spray cooling
    Brian M Pikkula
    Department of Bioengineering, Rice University, Houston, TX 77251, USA
    Ann Biomed Eng 31:493-504. 2003
    ..Data demonstrate that during CSC, evaporation is the dominant heat transfer mechanism in materials with higher thermal diffusivities; however, conductive cooling dominates in substrates with lower thermal diffusivities such as skin...
  100. ncbi [Hydrofluoroalkane as a propellant for pressurized metered-dose inhalers: history, pulmonary deposition, pharmacokinetics, efficacy and safety]
    Cassio C Ibiapina
    Universidade Federal de Minas Gerais UFMG, Belo Horizonte, MG
    J Pediatr (Rio J) 80:441-6. 2004
    ..To review the literature about hydrofluoroalkane as a propellent of pressurized metered-dose inhalers containing anti-asthma drugs...
  101. ncbi Polyfluoroalkyl chemicals in pooled blood serum from infants, children, and adults in Australia
    Leisa Maree L Toms
    The University of Queensland, National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, Queensland 4108, Australia
    Environ Sci Technol 43:4194-9. 2009
    ....

Research Grants44

  1. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  2. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  3. DOES HYPOXIA PREDICT RADIATION/SURGICAL TUMOR RESPONSE?
    Sydney Evans; Fiscal Year: 2005
    ..Primary endpoints of survival analyses will be metastasis in soft tissue sarcoma patients and local- regional recurrence in head and neck squamous cell carcinoma patients. ..
  4. Microenvironment: Imaging/Implications in Brain Tumors
    Sydney Evans; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  5. Evaluation of Hypoxia by EF5 Binding in Cervix Cancer
    Sydney Evans; Fiscal Year: 2003
    ..This will allow conversion of binding to tumor pO2. Further analyses will incorporate the area of tissue involved at various binding levels. Patient follow-up and statistical evaluations will be provided by the GOG. ..
  6. Assessment of Hypoxia in Malignant Gliomas Using EF5
    Sydney Evans; Fiscal Year: 2002
    ..We project that we will be able to institute clinical EF5 PET studies at PENN in patients with brain tumors in approximately 2 years, corresponding to the time that much of the data from the studies proposed herein will mature. ..
  7. Oxidative Damage to DNA Repair Pathways
    Cameron Koch; Fiscal Year: 2006
    ..Specific Aim 3 will investigate other aspects of DNA repair and DNA structural organization to determine their sensitivity to redox regulation. ..
  8. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
    ..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
  9. Predicting Radiation Response by Tumor pO2
    Cameron Koch; Fiscal Year: 2006
    ..DDFP may thus be the first PFC emulsion practical and safe for use in multifraction clinical regimens. ..
  10. Purchase of a 600 MHz NMR Spectrometer with Cryoprobe
    DENNIS CURRAN; Fiscal Year: 2007
    ..This research often requires sophisticated NMR experiments on small samples, and the requested 600 MHz spectrometer will greatly expedite ongoing and planned work. [unreadable] [unreadable] [unreadable]..
  11. RADICAL REACTIONS FOR NATURAL PRODUCTS
    DENNIS CURRAN; Fiscal Year: 2002
    ....
  12. FLUOROUS METHODS FOR TRADITIONAL AND PARALLEL SYNTHESIS
    DENNIS CURRAN; Fiscal Year: 2003
    ..In short, the work will help to move the very young field of fluorous chemistry from infancy into childhood. ..
  13. Rapid Fluorous Synthesis of Drug-Like Small Molecules
    Wei Zhang; Fiscal Year: 2005
    ....
  14. ANESTHETIC RENAL METABOLISM--MECHANISMS AND CONSEQUENCES
    Evan Kharasch; Fiscal Year: 2002
    ..More broadly, resulting biochemical and clinical insights will be applicable to the numerous other nephrotoxic haloalkenes that are ubiquitous environmental contaminants. ..
  15. Solution Phase Libraries by Fluorous Mixture Synthesis
    Wei Zhang; Fiscal Year: 2002
    ..The company plans to use the techniques in- house for contract library synthesis and to make them available to the community at large. ..
  16. Novel noninvasive assessment of cytochrome P450 activity
    Evan Kharasch; Fiscal Year: 2009
    ..This approach may identify inter-individual variability in drug disposition and response;permit more individualized dosing, and reduces the cost of drug interaction studies. ..
  17. Neurorestorative Therapy of Stroke with Statins
    Jieli Chen; Fiscal Year: 2007
    ..This study provides a new and highly effective way to treat stroke and may permit translation our finding of restorative therapeutic benefit of statin in experimental stroke to the patient. ..
  18. Phosphoinositide and Inositol Polyphosphate Probes
    Glenn Prestwich; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  19. Development of a Highly Efficient Personal Sampler to collect Viable Bioaerosols
    Yung Sung Cheng; Fiscal Year: 2010
    ..The new device will not only be beneficial in occupational settings, but may also have future potential in high risk areas such as those following any possible biological attack. ..
  20. The Role of 11beta-HSD1 in Type II Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  21. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
    ..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
  22. Sustained Release Pulmonary Delivery for Improved Cystic Fibrosis Treatment
    Hugh Smyth; Fiscal Year: 2008
    ..These R03 feasibility studies, initiate a long term goal of applying drug delivery approaches to CF therapy. [unreadable] [unreadable] [unreadable]..
  23. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. ABCs of Intestinal Sterol Transport
    F Field; Fiscal Year: 2009
    ..The results of this proposal will provide new and novel information on the roles of the ABC transporters, NPC1L1, and lipid rafts in intestinal sterol metabolism ..
  25. Defining Molecular Markers for Tumor Hypoxia
    QUYNH THU XUAN LE; Fiscal Year: 2010
    ..abstract_text> ..
  26. Platelet-Derived Growth Factor, Remodeling and Asthma
    Monica Kraft; Fiscal Year: 2010
    ..This proposal will also determine whether PDGF inhibition could provide important adjuvant therapy for the treatment of severe asthmatics by limiting structural changes that result from activity of this pathway. ..
  27. Safety and Efficacy of Sertraline for Depression Congestive Heart Failure
    Ranga Krishnan; Fiscal Year: 2007
    ..Information collected in these follow-up contacts will include deaths, re-hospitalizations, cardiac events, functional status/quality of life measures, and level of depressive symptoms. ..
  28. Simultaneous PET imaging of rCBF and dopamine release
    ALEXANDER CONVERSE; Fiscal Year: 2006
    ....
  29. Involvement of Myeloperoxidase in Atherosclerosis
    Wanda Reynolds; Fiscal Year: 2006
    ..These studies will reveal if MPO-generated oxidants promote atherosclerosis in mouse models, thereby humanizing existing mouse models, and enabling investigations of the role of MPO-mediated oxidation in atherosclerosis. ..
  30. DEPRESSION IN ELDERLY CARDIAC PATIENTS
    Ranga Krishnan; Fiscal Year: 2003
    ....
  31. CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANS
    Stephen Peters; Fiscal Year: 2001
    ....
  32. BIOCHEMICAL TOXICOLOGY AND MOLECULAR STRESS RESPONSES
    Takaharu Ichimura; Fiscal Year: 2004
    ..An initial prototype compound that is effective in inducing stress response genes and tolerance to injury in vitro and in vivo has been developed as part of the application. ..
  33. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
    ..abstract_text> ..
  34. Crosslinkable Hydrogels for Tympanic Membrane Repair
    Glenn Prestwich; Fiscal Year: 2004
    ..Third, we will evaluate the biocompability and otocompability of each gel in vivo by evaluating recovery of auditory function and middle ear histology. ..
  35. Synthesis/Biological evaluation of Anti-HIV Nucleosides
    David Chu; Fiscal Year: 2005
    ..This is the first such studies demonstrating the potential of this molecular modeling approach. ..
  36. Elucidation of the Lipoxygenase-Mediated Pathway of Lun*
    PAUL MYRDAL; Fiscal Year: 2005
    ..abstract_text> ..
  37. Thiol-Reactive Crosslinkers for Biomaterials
    Glenn Prestwich; Fiscal Year: 2004
    ..Fourth, these new materials will be evaluated for cytocompatibility and cell growth in vitro with murine fibroblasts. Finally, selected materials will be seeded with fibroblasts and injected into nude mice for in vivo tissue generation. ..
  38. ABCA1: A Potential Therapeutic Target for AD
    Radosveta Koldamova; Fiscal Year: 2006
    ..abstract_text> ..
  39. Port wine stain treatment for infants and young children
    Guillermo Aguilar; Fiscal Year: 2006
    ..Ultimately, the combination of research, coursework, and clinic experience, will provide the applicant with the preparation to launch an independent and successful research career in biomedical engineering. ..
  40. Toll-Like Receptor 3 Activation in Astrocytes
    GREGORY KONAT; Fiscal Year: 2006
    ..Moreover, because TLR3 can also be activated by RNA released from damaged cells, the outcomes of this study will also be applicable to neurodegenerative conditions of non-viral etiology. [unreadable] [unreadable]..
  41. Inhalation Dosimetry/Exposure Index of Fiber Aerosol
    Yung Sung Cheng; Fiscal Year: 2006
    ..Sampling devices based on this size-selection definition can be developed in the future for improved assessment of worker exposure. ..
  42. SQUALENE AND OXIDOSQUALENE CYCLASES
    Glenn Prestwich; Fiscal Year: 2002
    ....
  43. ASTHMA CLINICAL RESEARCH NETWORK (ACRN)
    Stephen Peters; Fiscal Year: 2007
    ....