methane chlorofluorocarbons

Summary

Summary: A group of methane-based halogenated hydrocarbons containing one or more fluorine and chlorine atoms.

Top Publications

  1. ncbi Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction
    Bengt Sjögren
    Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:205-7. 2002
  2. ncbi Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases
    Takeshi Kubota
    Department of Anesthesia, Hachinohe Heiwa Hospital, Hachinohe, Japan
    Clin Toxicol (Phila) 43:305-8. 2005
  3. ncbi Formation of quaternary carbon center with a trifluoromethyl group using a Pd-catalyzed allylation reaction
    Kazuyuki Sato
    Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Chem Pharm Bull (Tokyo) 55:1593-6. 2007
  4. ncbi Infrared spectra and relative stability of the F3CH/NH3 H-bonded complex in liquefied Xe
    K S Rutkowski
    Institute of Physics, St Petersburg University, 1 Ulianovskaja st, 198504 St Petersburg, Peterhof, Russia
    Spectrochim Acta A Mol Biomol Spectrosc 61:1595-602. 2005
  5. ncbi An experimental and kinetic modeling study of the reaction of CHF3 with methane
    Hai Yu
    Process Safety and Environment Protection Research Group, School of Engineering, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    Environ Sci Technol 40:5778-85. 2006
  6. ncbi Short-term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydrofluoroalkane-134a
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:613-9. 2006
  7. ncbi Characterisation of the aggregation behaviour in a salmeterol and fluticasone propionate inhalation aerosol system
    Y Michael
    School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London SE18 6PF, UK
    Int J Pharm 221:165-74. 2001
  8. ncbi Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether
    Sofie N Delanoye
    Department of Chemistry, Universitair Centrum Antwerpen, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Am Chem Soc 124:7490-8. 2002
  9. ncbi The influence of redox potential on the degradation of halogenated methanes
    Yolanda Olivas
    Biology Department, New Mexico State University, Las Cruces 88003, USA
    Environ Toxicol Chem 21:493-9. 2002
  10. ncbi Multiphoton dissociation/ionization of CHCl3 and CFCl3 at 355 nm: an experimental and theoretical study
    P Sharma
    Novel Materials and Structural Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Rapid Commun Mass Spectrom 18:2383-7. 2004

Research Grants

  1. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
  2. SYNCHRONOUS TRACER INJECTION FOR PULMONARY PARAMETERS
    Justin Clark; Fiscal Year: 1980

Detail Information

Publications155 found, 100 shown here

  1. ncbi Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction
    Bengt Sjögren
    Work Environment Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Scand J Work Environ Health 28:205-7. 2002
    ..Another week later he died due to myocardial infarction. The discussion focuses on an inflammatory process caused by the inhalation of decomposed freon and its possible association with myocardial infarction...
  2. ncbi Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases
    Takeshi Kubota
    Department of Anesthesia, Hachinohe Heiwa Hospital, Hachinohe, Japan
    Clin Toxicol (Phila) 43:305-8. 2005
    ..There were no fatalities. Although Freon-22 has been considered to be a chlorofluorocarbon of relatively low toxicity, this incident suggests that potentially significant toxic effects may occur following large exposures...
  3. ncbi Formation of quaternary carbon center with a trifluoromethyl group using a Pd-catalyzed allylation reaction
    Kazuyuki Sato
    Faculty of Pharmaceutical Sciences, Setsunan University, Hirakata, Osaka 573 0101, Japan
    Chem Pharm Bull (Tokyo) 55:1593-6. 2007
    ....
  4. ncbi Infrared spectra and relative stability of the F3CH/NH3 H-bonded complex in liquefied Xe
    K S Rutkowski
    Institute of Physics, St Petersburg University, 1 Ulianovskaja st, 198504 St Petersburg, Peterhof, Russia
    Spectrochim Acta A Mol Biomol Spectrosc 61:1595-602. 2005
    ..The ab initio interaction energy was found to be compatible with the isolated molecule complexation energy extrapolated from the experimental Delta(LXe)H degrees ...
  5. ncbi An experimental and kinetic modeling study of the reaction of CHF3 with methane
    Hai Yu
    Process Safety and Environment Protection Research Group, School of Engineering, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    Environ Sci Technol 40:5778-85. 2006
    ..Using the software package AURORA, the reaction pathways leading to the formation of major products are elucidated...
  6. ncbi Short-term growth and adrenal function in children with asthma treated with inhaled beclomethasone dipropionate hydrofluoroalkane-134a
    O D Wolthers
    Children s Clinic Randers, Randers, Denmark
    Pediatr Allergy Immunol 17:613-9. 2006
    ..Though non-inferiority between BDP HFA and CFC 100 microg twice daily in terms of effects on LLGR was not found, equivalence was suggested by comparisons of LLGR during run-in and active treatments and by HPA function measures...
  7. ncbi Characterisation of the aggregation behaviour in a salmeterol and fluticasone propionate inhalation aerosol system
    Y Michael
    School of Chemical and Life Sciences, University of Greenwich, Wellington Street, Woolwich, London SE18 6PF, UK
    Int J Pharm 221:165-74. 2001
    ..The interaction between the two drugs was such that they did not separate on creaming, despite having different densities. The average floc size of the combined drug suspension was also found to depend on the dispersion medium...
  8. ncbi Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether
    Sofie N Delanoye
    Department of Chemistry, Universitair Centrum Antwerpen, Groenenborgerlaan 171, B 2020 Antwerp, Belgium
    J Am Chem Soc 124:7490-8. 2002
    ..The model calculations also show that the electric field effect accounts for the observed intensity changes of the haloform C[bond]H stretches...
  9. ncbi The influence of redox potential on the degradation of halogenated methanes
    Yolanda Olivas
    Biology Department, New Mexico State University, Las Cruces 88003, USA
    Environ Toxicol Chem 21:493-9. 2002
    ..The Gibbs free energy and the redox potential for the dehalogenation reactions utilizing Ti (III) citrate and acetate as electron donors are reported here for the first time...
  10. ncbi Multiphoton dissociation/ionization of CHCl3 and CFCl3 at 355 nm: an experimental and theoretical study
    P Sharma
    Novel Materials and Structural Chemistry Division, Bhabha Atomic Research Centre, Mumbai 400 085, India
    Rapid Commun Mass Spectrom 18:2383-7. 2004
    ..The absence of [CFCl]+ has been interpreted on the basis of resonant A state-mediated two-photon absorption by CFCl, and the subsequent prompt photodissociation processes occurring for this state...
  11. ncbi The nature of improper, blue-shifting hydrogen bonding verified experimentally
    B J van der Veken
    Department of Chemistry, Universitair Centrum Antwerpen, Groenenborgerlaan 171, B-2020 Antwerp, Belgium
    J Am Chem Soc 123:12290-3. 2001
    ..It is thus clearly demonstrated that not only the spectral manifestation of H-bonding and improper H-bonding but also their nature differ...
  12. ncbi Experimental and computational studies of the gas-phase reaction of halon 1211 with hydrogen
    Hai Yu
    Process Safety and Environment Protection Research Group, School of Engineering, The University of Newcastle, Callaghan, New South Wales 2308, Australia
    Environ Sci Technol 39:3020-8. 2005
    ..Using the software package AURORA, the reaction pathways leading to the formation of major products are elucidated. It has been found that the reaction steps involving CF2 are responsible for the formation of CH4...
  13. ncbi Theoretical study of (CH...C)- hydrogen bonds in CH(4-n)X(n) (X = F, Cl; n = 0, 1, 2) systems complexed with their homoconjugate and heteroconjugate carbanions
    Asit K Chandra
    Department of Chemistry, North Eastern Hill University, Shillong, 793022 India
    J Phys Chem A 109:12006-13. 2005
    ..The frequency shifts of the nu(CH)(A1) stretching vibration range between 15 and 1150 cm(-1). They are linearly correlated to the elongation of the CH(b) bond...
  14. pmc Reactive airways dysfunction syndrome caused by bromochlorodifluoromethane from fire extinguishers
    M Matrat
    Unité de pathologie professionnelle, Service de pneumologie et pathologie professionnelle, CHI Creteil, France
    Occup Environ Med 61:712-4. 2004
    ..The diagnosis of reactive airways dysfunction syndrome can be adopted in at least three of these four cases...
  15. ncbi Accounting for the effects of moderately increased pressure on the energetics of melting and solubility in metered dose inhalers
    Erik Mogalian
    College of Pharmacy, University of Arizona, Tucson, AZ 85721, USA
    Drug Dev Ind Pharm 34:930-5. 2008
    ..Based on the findings, modest changes can be made to predictive models to estimate solubility in propellant systems to account for changes in the physical environment of MDIs...
  16. ncbi An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay
    Masumi Asakura
    Japan Bioassay Research Center, Japan Industrial Safety and Health Association, Hadano, Kanagawa, Japan
    Mutat Res 652:122-30. 2008
    ..This improved gas exposure system proved to be useful for detecting chromosomal aberrations of gaseous compounds...
  17. ncbi Dichlorodifluoromethane decomposition to CO2 with simultaneous halogen fixation by calcium oxide based materials
    Tsukasa Tamai
    Department of Environmental Chemistry and Engineering, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama 226 8502, Japan
    Environ Sci Technol 40:823-9. 2006
    ..During the preparation, nickel oxide was reduced to the metal phase. CCl2F2 was decomposed to CO2 with a small amount of CO, and halogens were fixed as CaFCl, without significant deactivation at 723 K...
  18. ncbi [Trends and variation of CFC-11 in the atmosphere of Beijing]
    Tian Yang Xiu
    Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China
    Huan Jing Ke Xue 26:1-6. 2005
    ..7%. The average concentration of CFC-11 in the atmosphere of Beijing was 3 to approximately 5 times of the average concentration of CFC-11 in the atmosphere of Mauna Loa Station of U.S.A...
  19. ncbi Quantitative determination of Freon gas using an electronic nose
    Lijing Wen
    Department of Chemistry, Fudan University, Shanghai, China
    Analyst 127:786-91. 2002
    ..The results show that the Freon enose developed in this study is reliable for both the qualitative and quantitative determination of Freon gas and exhibits the merits of high sensitivity, anti-interference and accuracy...
  20. ncbi Rotational spectrum and structure of the carbonyl sulfide-trifluoromethane weakly bound dimer
    Michal M Serafin
    Department of Chemistry, Eastern Illinois University, 600 Lincoln Avenue, Charleston, Illinois 61920, USA
    J Phys Chem A 110:11938-43. 2006
    ..O interactions. Ab initio calculations at the MP2/6-311++G(2d,2p) level give a structure with rotational constants that are in reasonable agreement with those of the normal isotopic species...
  21. ncbi Molecular beam rotational spectrum of cyclobutanone-trifluoromethane: nature of weak CH...O=C and CH...F hydrogen bonds
    Paolo Ottaviani
    Dipartimento di Chimica G Ciamician dell Università, Bologna, Italy
    Chemistry 12:915-20. 2006
    ..The two C-H...F-C weak hydrogen bonds involve two fluorine atoms of trifluoromethane and two hydrogens of the same methylenic group in the alpha position...
  22. pmc Cloud banks: airlines save halon
    Adrian Burton
    Environ Health Perspect 114:A95. 2006
  23. ncbi Trifluoromethyl derivatives of insoluble small-HOMO-LUMO-gap hollow higher fullerenes. NMR and DFT structure elucidation of C2-(C74-D3h)(CF3)12, Cs-(C76-Td(2))(CF3)12, C2-(C78-D3h(5))(CF3)12, Cs-(C80-C2v(5))(CF3)12, and C2-(C82-C2(5))(CF3)12
    Natalia B Shustova
    Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA
    J Am Chem Soc 128:15793-8. 2006
    ....
  24. ncbi Reversible control of enzymatic transglycosylations in supercritical fluoroform using a lipid-coated beta-D-galactosidase
    Toshiaki Mori
    Department of Biomolecular Engineering, Tokyo Institute of Technology, 4259 Nagatsuda, Midori ku, Yokohama 226 8501, Japan
    J Am Chem Soc 124:1188-9. 2002
    ..The transgalactosylation rate catalyzed by the lipid-coated beta-d-galactosidase in supercritical fluoroform (scCHF3) can be reversibly controlled by changing temperature or pressure (reflecting polarity changes) without damaging enzymes...
  25. ncbi Gas-phase reaction of CCl2F2 (CFC-12) with methane
    Md Azhar Uddin
    Process Safety and Environment Protection Group, School of Engineering, The University of Newcastle, Callaghan, NSW 2308, Australia
    Chemosphere 53:1189-91. 2003
    ..Under these reaction conditions, methane acts as hydrogen and carbon source, resulting in the formation of an unsaturated C2 hydrofluorocarbon from two C1 precursors...
  26. ncbi Transport of hydrocarbons from an emplaced fuel source experiment in the vadose zone at Airbase Vaerløse, Denmark
    Mette Christophersen
    Institute of Environment and Resources, Technical University of Denmark, Building 115, DK 2800 Kgs Lyngby, Denmark
    J Contam Hydrol 81:1-33. 2005
    ..However that did not influence the direction of the groundwater flow. Approximately 7 months after source emplacement the groundwater table rose more than 1 m within 1 month. That did not cause additional pollution of the groundwater...
  27. ncbi A novel apparatus for the determination of solubility in pressurized metered dose inhalers
    Daniela Traini
    Advanced Drug Delivery Group, Faculty of Pharmacy A15, University of Sydney, Sydney, NSW 2006, Australia
    Drug Dev Ind Pharm 32:1159-63. 2006
    ..136 +/- 2.951 microg x g(-1) and 0.776 +/- 1.023 microg x g(-1), respectively (n = 3). This novel solubility apparatus offers an improved ease of use and potential higher analytical throughput...
  28. ncbi An accidental death due to Freon 22 (monochlorodifluoromethane) inhalation in a fishing vessel
    Ako Koreeda
    Department of Forensic Medicine, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
    Forensic Sci Int 168:208-11. 2007
    ..Lipofuscin in the liver, which closely relates to aging and other cell stresses, could have a relevance to Freon 22 exposure, but further experimental studies are needed to confirm it...
  29. ncbi Surface free energy of a solid from contact angle hysteresis
    Emil Chibowski
    Department of Physical Chemistry Interfacial Phenomena, Faculty of Chemistry, Maria Curie Skłodowska University, 20031 Lublin, Poland
    Adv Colloid Interface Sci 103:149-72. 2003
    ....
  30. ncbi Innovations and perspectives of metered dose inhalers in pulmonary drug delivery
    M Keller
    SkyePharma AG, Eptingerstrasse 51, CH 4132, Muttenz, Switzerland
    Int J Pharm 186:81-90. 1999
    ..These issues must be considered in the development of future devices and formulations...
  31. ncbi Selective detection of alkanolamine vapors by ion mobility spectrometry with ketone reagent gases
    T H Gan
    Aeronautical and Maritime Research Laboratory, Defence Science and Technology Organization, Melbourne, Victoria, Australia
    Anal Chem 72:807-15. 2000
    ....
  32. ncbi A validated method for the quantitation of 1,1-difluoroethane using a gas in equilibrium method of calibration
    Joseph Avella
    Department of Pharmaceutical Sciences, St John s University, Jamaica, New York, USA
    J Anal Toxicol 32:680-7. 2008
    ....
  33. ncbi Tolerability and in vivo performance of a novel freon-free metered dose inhaler for a fixed combinational product of reproterol and disodium cromoglycate
    R Hermann
    ASTA Medica AG, Department of Clinical Pharmacology, Frankfurt Main, Germany
    Arzneimittelforschung 48:663-7. 1998
    ..It is concluded that the safety, tolerability and in vivo performance of the newly developed freon-free MDI is at least as well tolerable as the already marketed freon-driven conventional formulation...
  34. ncbi Dermabrasion using CO2 dry ice
    J E Fulton
    Fulton Skin Institute, Newport Beach, California, USA
    Dermatol Surg 25:544-8. 1999
    ..The recent withdrawal of Freon from the market has made dermabrasion more difficult...
  35. ncbi An evaluation of field total petroleum hydrocarbon (TPH) systems
    P Lambert
    Emergencies Science Division, Environment Canada, Ottawa, Ont, Canada K1A 0H3
    J Hazard Mater 83:65-81. 2001
    ..Results generated by the kit are dependent upon the color and amount of the oil in the sample. The kit is best suited for dark colored oils and the water samples with concentrations in the range of 10 to 85ppm by weight...
  36. ncbi Characterization of odor-active compounds in Californian chardonnay wines using GC-olfactometry and GC-mass spectrometry
    Seung Joo Lee
    Department of Viticulture and Enology, University of California, Davis, California 95616, USA
    J Agric Food Chem 51:8036-44. 2003
    ....
  37. ncbi Multisorbent tubes for collecting volatile organic compounds in spacecraft air
    M L Matney
    Wyle Laboratories, Inc, Life Sciences Systems and Services, Houston, TX 77058, USA
    AIHAJ 61:69-75. 2000
    ..Acetaldehyde had the lowest recovery (75%) of the 10 compounds, but this value was still an improvement over either the other two sorbent combinations or the original single-sorbent tubes...
  38. ncbi A new method to evaluate plume characteristics of hydrofluoroalkane and chlorofluorocarbon metered dose inhalers
    B J Gabrio
    3M Pharmaceuticals, St Paul, MN 55144 1000, USA
    Int J Pharm 186:3-12. 1999
    ..Data obtained from marketed products and experimental inhalers show that MDIs that have a low spray force also have low throat deposition...
  39. ncbi A comparative study of the ability of different solvents and adsorbents to extract aroma compounds from alcoholic beverages
    V Ferreira
    Department of Analytical Chemistry, Faculty of Sciences, University of Zaragoza, Spain
    J Chromatogr Sci 38:469-76. 2000
    ..Results indicate that in all cases liquid solvents can be replaced satisfactorily by SPE systems...
  40. ncbi Occupational exposures during the World Trade Center disaster response
    K M Wallingford
    National Institute for Occupational Safety and Health 4676 Columbia Parkway R 11, Cincinnati, Ohio 45226, USA
    Toxicol Ind Health 17:247-53. 2001
    ..Recommendations were made to ensure adequate ventilation and worker understanding when using these tools and, where possible, to substitute rechargeable, battery-powered cutting saws for gasoline-powered ones. Toxicology..
  41. pmc Reverse transcriptase PCR detection of astrovirus, hepatitis A virus, and poliovirus in experimentally contaminated mussels: comparison of several extraction and concentration methods
    O Traore
    Service d Hygiène, Faculte de Medecine, 63000 Clermont Fd Cedex, France
    Appl Environ Microbiol 64:3118-22. 1998
    ..Detoxification of the samples by Sephadex LH20 filtration significantly decreased the efficiency of RT-PCR virus detection...
  42. ncbi High-resolution broadband (>100 cm-1) infrared heterodyne spectro-radiometry using an external cavity quantum cascade laser
    Damien Weidmann
    Space Science and Technology Department, STFC Rutherford Appleton Laboratory, Harwell Science and Innovation Campus, Didcot, Oxfordshire, UK
    Opt Express 17:248-59. 2009
    ..In each case concentration retrievals are performed and analyzed. The spectroradiometer noise level is demonstrated to be twenty two and eight times the fundamental shot-noise limit in the two scanning modes respectively...
  43. ncbi Comparative study of techniques used to recover viruses from residual urban sludge
    B Mignotte
    U M R University CNRS 7564, Laboratory of Virology, Faculty of Pharmacy, Nancy, France
    J Virol Methods 78:71-80. 1999
    ..3 M NaCl/7% beef extract solution at pH 7.5 and freon, and finally using a 0.1 M borate buffer/3% beef extract solution at pH 9 and sonication...
  44. ncbi Nuclear magnetic resonance and ab initio studies of small complexes formed between water and pyridine derivatives in solid and liquid phases
    Shasad Sharif
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, D 14195 Berlin, Germany
    J Phys Chem A 111:6084-93. 2007
    ..The obtained experimental data indicated that at these conditions water trended to form the symmetric 2:1 heterocycle-water complexes, whose bridge protons resonated around 6.7 ppm...
  45. ncbi Freon: accidental ingestion and gastric perforation
    Mariano Javier Gotelli
    Centro de Investigaciones Toxicologicas, School of Medicine, University of Buenos Aires, Argentina
    Clin Toxicol (Phila) 46:325-8. 2008
    ..Currently, intoxication reports are unintentional inhalation of CFCs. We report an unintentional ingestion of a mixture of CFCs and the results of a rat study...
  46. ncbi Ion chemistry of anti-o,o dibenzene
    K Schroeter
    , , Germany
    Chemistry 6:4422-30. 2000
    ..No evidence for the existence of 1/Fe+ was obtained, which suggests that iron mediates the rapid retrocyclization of 1/Fe+ into the bis-ligated benzene complex [(C6H6)2Fe]+...
  47. ncbi Partial ion yield spectroscopy around the Cl 2p and C 1s ionization thresholds in CF3Cl
    D Ceolin
    Department of Physics and Materials Science, Uppsala University, P O Box 530, SE 751 21 Uppsala, Sweden
    J Chem Phys 131:244301. 2009
    ..Equally, by comparison with their cation counterpart, we discuss possible bond-length dependence for the anion formation at the carbon 1s edge...
  48. ncbi [Efficacy and safety assessment program of fusafungin in the treatment of acute upper respiratory tract infections in adults (PROFIL): multicenter study in Poland]
    Dariusz Jurkiewicz
    Klinika Otolaryngologii CSK WAM w Warszawie
    Pol Merkur Lekarski 14:189-93. 2003
    ..Fusafungine in a new (without freon) form is efficacy and safety drugs in the treatment of upper respiratory tract infections in adults...
  49. ncbi Modified direct relining method produces an accurate adaptation of denture
    Yukinori Maruo
    Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama 700 8558, Japan
    Dent Mater J 24:311-4. 2005
    ..Based on the results of this study, we therefore suggested that this delayed and lowered temperature served to improve the adaptability of denture base...
  50. ncbi Chlorine-catalyzed ozone destruction: Cl atom production from ClOOCl photolysis
    David M Wilmouth
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    J Phys Chem A 113:14099-108. 2009
    ..These new measurements demonstrate that long-wavelength photons (lambda = 352 nm) are absorbed by ClOOCl directly, producing Cl atoms with a probability commensurate with the observed rate of ozone destruction in the atmosphere...
  51. ncbi Symmetrization of cationic hydrogen bridges of protonated sponges induced by solvent and counteranion interactions as revealed by NMR spectroscopy
    Mariusz Pietrzak
    Institut fur Chemie und Biochemie, Freie Universitat Berlin, Takustrasse 3, Berlin, Germany
    Chemistry 16:1679-90. 2010
    ..By contrast, toluene molecules that are ordered around the cation led to typical high-field shifts of the hydrogen-bonded proton as well as of those bound to carbon, an effect that is absent in the case of neutral NHN chelates...
  52. ncbi European emissions of HFC-365mfc, a chlorine-free substitute for the foam blowing agents HCFC-141b and CFC-11
    Konrad Stemmler
    Air Pollution and Environmental Technology, Empa, Swiss Federal Laboratories for Materials Testing and Research, Dubendorf, Switzerland
    Environ Sci Technol 41:1145-51. 2007
    ..In 2004, the emissions of HFC-365mfc arose from a wider region of Europe, which we attribute to an increased penetration of HFC-365mfc into the European market...
  53. ncbi Simultaneous determination of CFC-11, CFC-12 and CFC-113 in seawater samples using a purge and trap gas-chromatographic system
    Serena Massolo
    Department of Chemistry and Industrial Chemistry, University of Genoa, Genoa, Italy
    Talanta 80:959-66. 2009
    ..The system has been successfully employed for CFC measurements in seawater samples collected in the Ross Sea (Antarctica) in the framework of the Italian Antarctic research project...
  54. pmc The productive merger of iodonium salts and organocatalysis: a non-photolytic approach to the enantioselective alpha-trifluoromethylation of aldehydes
    Anna E Allen
    Merck Center for Catalysis, Princeton University, Princeton, New Jersey 08544, USA
    J Am Chem Soc 132:4986-7. 2010
    ..This mild and operationally simple protocol allows rapid access to enantioenriched alpha-trifluoromethylated aldehydes through a nonphotolytic pathway...
  55. ncbi [Freon gas frostbite: an unusual burn evolving in two stages]
    B Chaput
    Service de Chirurgie Plastique et Reconstructrice, CHU de Toulouse Rangueil, avenue du Professeur Jean Poulhes, 31059 Toulouse, France
    Chir Main 31:166-9. 2012
    ..This evolution in two phases has never been described and could help to better understand the pathophysiology of this frostbite and the possibilities of management...
  56. ncbi Identification of volatiles by headspace gas chromatography with simultaneous flame ionization and mass spectrometric detection
    Nicholas B Tiscione
    1 Palm Beach County Sheriff s Office, 3228 Gun Club Road, West Palm Beach, FL 33406, USA
    J Anal Toxicol 37:573-9. 2013
    ..The validation for qualitative identification included evaluation of matrix effects, sensitivity, carryover, specificity, repeatability and ruggedness/robustness...
  57. ncbi IR Band profiling of dichlorodifluoromethane in the greenhouse window: high-resolution FTIR spectroscopy of ν2 and ν8
    Corey J Evans
    Department of Chemistry, University of Leicester, University Road, Leicester LE1 7RH, U K
    J Phys Chem A 118:2480-7. 2014
    ..Together these new sets of constants allow for accurate prediction of these bands and direct comparison with satellite data to enable accurate quantification...
  58. ncbi A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
    Chaweewan Bunnag
    Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand
    Asian Pac J Allergy Immunol 25:99-109. 2007
    ..Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers...
  59. ncbi Aspects of 6-[18F]fluoro-L-DOPA preparation. Deuterochloroform as a substitute solvent for Freon 11
    F Fuchtner
    Institute of Radiopharmacy, Forschungszentrum Dresden Rossendorf, Dresden, Germany
    Nuklearmedizin 47:62-4. 2008
    ....
  60. ncbi Small airway asthma therapy, challenges, and the future
    Thomas B Casale
    Center for Allergy, Asthma and Immunology, Creighton University, Omaha, NE 68131, USA
    Postgrad Med 113:15-20. 2003
    ..By extending the delivery of this medication to the peripheral lung and by increasing the efficiency of lung targeting, these new corticosteroid formulations provide more effective treatment at reduced drug doses...
  61. pmc Grand rounds: outbreak of hematologic abnormalities in a community of people exposed to leakage of fire extinguisher gas
    Shih Hsiang Lo
    Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan
    Environ Health Perspect 114:1713-7. 2006
    ....
  62. ncbi EPR studies of amine radical cations. Part 2. Thermal and photo-induced rearrangements of propargylamine and allylamine radical cations in low-temperature freon matrices
    Wolfgang Knolle
    Leibniz Institut für Oberflächenmodifizierung IOM, Permoserstrasse 15, D 04303 Leipzig, Germany
    J Phys Chem A 110:13816-26. 2006
    ..This is in line with calculations showing that the thermal barrier for this transformation is much higher (approximately 120 kJ mol-1) than those for the conversion of 1b*+ --> 2*+ and 5*+--> 6*+ (approximately 40-60 kJ mol-1)...
  63. ncbi Daily physicochemical, microbiological and ecotoxicological fluctuations of a hospital effluent according to technical and care activities
    C Boillot
    Universite de Lyon, Ecole Nationale des Travaux Publics de l Etat, Vaulx en Velin, France
    Sci Total Environ 403:113-29. 2008
    ..They concern: reactions of fermentations likely to occur in the drainage network and to form secondary toxic compounds, retention of chlorine by particles and physicochemical characterization of suspended solids...
  64. ncbi Simultaneous conversion of CHClF(2) and CH(3)Br to CH(2)CF(2)
    Hai Yu
    Process Safety and Environment Protection Research Group, School of Engineering, The University of Newcastle, Callaghan, NSW 2308, Australia
    Chemosphere 68:2003-6. 2007
    ..The reaction of CHClF(2) with CH(3)Cl and CH(3)I was also investigated under similar reaction conditions, to assist in understanding the reaction chemistry involved in the reaction of CHClF(2) with CH(3)Br...
  65. ncbi RCM-mediated synthesis of trifluoromethyl-containing nitrogen heterocycles
    Valeria De Matteis
    Institute for Molecules and Materials, Radboud University Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands
    J Org Chem 71:7527-32. 2006
    ....
  66. ncbi Conformationally rigid trifluoromethyl-substituted alpha-amino acid designed for peptide structure analysis by solid-state 19F NMR spectroscopy
    Pavel K Mikhailiuk
    Department of Chemistry, Kyiv National Taras Shevchenko University, Volodymyrska 64, 01033 Kyiv, Ukraine
    Angew Chem Int Ed Engl 45:5659-61. 2006
  67. ncbi Bubble detector investigations in China
    Shi Lun Guo
    China Institute of Atomic Energy, P O Box 275 96, Beijing 102413, China
    Radiat Prot Dosimetry 120:491-4. 2006
    ..The key parameter behind the thresholds of bubble detectors for track registration is the critical rate of energy loss. Three approaches to identify high-energy heavy ions with bubble detectors are suggested...
  68. ncbi The simple SDD
    A C Fernandes
    Instituto Tecnologico e Nuclear, Estrada Nacional 10, P 2686 953 Sacavém, Portugal
    Radiat Prot Dosimetry 120:503-8. 2006
    ....
  69. pmc A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias
    Zhe Jiao
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, and Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    J Mol Cell Cardiol 41:698-705. 2006
    ..The slowing of conduction is most likely related to changes in the phosphorylation state of Cx43...
  70. ncbi Neutron spectrometry with large volume, heavy-loaded superheated droplet detectors: a simple spin-off
    A R Ramos
    Instituto Tecnologico e Nuclear, EN 10, 2686 953 Sacavem, Portugal
    Radiat Prot Dosimetry 115:398-402. 2005
    ..Results show that the characteristic peaks in the fluence distribution of both filters could be determined and their energy position obtained using a simple thermodynamic relation...
  71. ncbi Determination of furaneol (4-hydroxy-2,5-dimethyl-3(2H)-furanone) in some wines from Italian native grapes by Gas-Chromatography-SIM/MASS spectrometry
    Alessandro Genovese
    Dipartimento di Scienze degli Alimenti, Universita degli Studi di Foggia, Facoltà di Agraria Via Napoli 25, 71100 Foggia, Italy
    Ann Chim 95:415-9. 2005
    ..Among white wines, Chardonnay resulted characterized by the highest concentration of HDMF. Among red wines the highest concentrations of HDMF were detected in Primitivo and Refosco varieties...
  72. ncbi Chlorodifluoromethyl-substituted monosaccharide derivatives--radical activation of the carbon-chlorine-bond
    Anita Wegert
    Institut fur Chemie, Organische Chemie, Universitat Rostock, Albert Einstein Strasse 3a, D 18059 Rostock, Germany
    Carbohydr Res 341:2641-52. 2006
    ....
  73. ncbi Effect of spurt duration on the heat transfer dynamics during cryogen spray cooling
    Guillermo Aguilar
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Phys Med Biol 48:2169-81. 2003
    ..Based on the results of this model skin phantom, it is shown that spurts longer than 40 ms have a negligible impact on both q and Q within clinically relevant cooling times (10-100 ms)...
  74. ncbi Decomposition of halogenated methanes in oxygen-free gas mixtures by the use of a silent electric discharge
    K A Föglein
    Department of Inorganic and Analytical Chemistry, University of Szeged, H 6701 Szeged, PO Box 440, Hungary
    Chemosphere 50:9-13. 2003
    ..The decomposition of CCl4 was faster than that of the cholorofluoromethanes, and produced perchloroethane and chlorine. CHCl3 exhibited the highest decomposition rate and produced a large variety of products...
  75. ncbi [Formulation of advancing products of pulmonary medicine absorption]
    György Stampf
    Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest Hógyes Endre u 7 1092
    Acta Pharm Hung 72:101-5. 2002
    ..The formation of enclosure complex can be proved by IR spectrum, and the complete dissolution was furthered by the OH groups of the auxiliary material...
  76. ncbi Improved method for the recovery of hepatitis A virus from oysters
    J L Mullendore
    US Food and Drug Administration, Gulf Coast Seafood Laboratory, Dauphin Island, AL 36528, USA
    J Virol Methods 94:25-35. 2001
    ..33 PFU of HAV seeded per RT-PCR reaction (corresponding to 111 PCR units). The method developed is capable of detecting low levels of HAV in oysters environmentally contaminated...
  77. ncbi Physiological disposition of aerosolized MK-679 in rats
    D J Tocco
    Merck Sharp and Dohme Research Laboratories, West Point, PA 19486
    Drug Metab Dispos 20:428-31. 1992
    ..The results of this study suggest that inhalation of MK-679 should be a considered route of administration for the treatment of asthma...
  78. ncbi Anti-HIV-1 activities and pharmacokinetics of new arylpiperazinyl fluoroquinolones
    Toshinori Ohmine
    Biological Research Laboratories, Sankyo Co, Ltd, 1 2 58 Hiromachi, Shinagawa ku, 140 8710, Tokyo, Japan
    Bioorg Med Chem Lett 12:739-42. 2002
    ..Two compounds studied exhibited quite high anti-HIV-1 activities (IC(50)<50 nM) in vitro and high bioavailabilities (BA>90%) in monkeys...
  79. ncbi Background monitoring and long-range transport of atmospheric CFC-11 and CFC-12 at Kosan, Korea
    J Kim
    Applied Meteorology Research Laboratory, Meterological Research Institute, Seoul, Korea
    Environ Monit Assess 70:47-56. 2001
    ..In particular, the mixing ratios of these two contaminant species are closely related with their air mass trajectories...
  80. ncbi Detection of chlorinated methanes by tin oxide gas sensors
    S H Park
    Department of Chemistry, University of Connecticut, Storrs 06269-3060, USA
    Analyst 126:1382-6. 2001
    ..The changes at the surface of the film after gas sensing were examined using scanning electron microscopy with energy-dispersive X-ray spectrometry...
  81. pmc A novel polyomavirus (goose hemorrhagic polyomavirus) is the agent of hemorrhagic nephritis enteritis of geese
    J L Guerin
    Unité Mixte de Recherche de Microbiologie Moléculaire, INRA ENVT, Ecole Nationale Veterinaire de Toulouse, Toulouse, France
    J Virol 74:4523-9. 2000
    ..Finally, based on phylogenetic analysis, we conclude that the causative agent of HNEG is closely related to but clearly distinct from other polyomaviruses; we thus have named this newly identified virus Goose hemorrhagic polyomavirus...
  82. ncbi [Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)]
    H Sun
    Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China
    Huan Jing Ke Xue 22:21-4. 2001
    ..With the study of other conditions, such as selection of the ECD temperature, programing of the column oven temperature and carrier gas flow, a practicable analysis method with high sensitivity of ECD was established...
  83. ncbi Allergic contact dermatitis from ethyl chloride and sensitization to dichlorodifluoromethane (CFC 12)
    A J Bircher
    Department of Dermatology, University Hospital, Basel, Switzerland
    Contact Dermatitis 31:41-4. 1994
    ..A modified patch test procedure using perforated plastic chambers to allow gas evaporation is necessary to test volatile agents...
  84. ncbi Sudden death caused by 1,1-difluoroethane inhalation
    Zhenggang Xiong
    Department of Pathology, State University of New York at Stony Brook, Stony Brook, NY, USA
    J Forensic Sci 49:627-9. 2004
    ..Tissue distribution studies revealed highest concentration in central blood, lung, and liver. It is believed that the 1,1-difluoroethane inhalation was the cause of death...
  85. ncbi A sensitive and robust method for quantification of intracellular short-chain coenzyme A esters
    Mark Shimazu
    Kosan Biosciences, Inc, 3832 Bay Center Place, Hayward, CA 94545, USA
    Anal Biochem 328:51-9. 2004
    ....
  86. ncbi 2-Chloro-2,2-difluoroacetophenone: a non-ODS-based difluorocarbene precursor and its use in the difluoromethylation of phenol derivatives
    Laijun Zhang
    Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China
    J Org Chem 71:9845-8. 2006
    ..This new and easy-to-handle synthetic methodology offers an environmentally friendly alternative to other Freon- or Halon-based difluoromethylating approaches...
  87. ncbi Simulation of special bubble detectors for PICASSO
    G Azuelos
    Groupe de Physique des Particules, Departement de Physique, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal Quebec H3C 3J7, Canada
    Radiat Prot Dosimetry 120:499-502. 2006
    ..Simulations performed to understand the detector response to neutrons and alpha particles are presented along with corresponding data obtained at the Montreal Laboratory...
  88. ncbi Helical self-assembly and co-assembly of fluorinated, preorganized discotics
    Michel H C J van Houtem
    Institute for Complex Molecular Systems and Laboratory of Organic and Macromolecular Chemistry, Eindhoven University of Technology, P O Box 513, 5600 MB Eindhoven, The Netherlands
    Org Biomol Chem 10:5898-908. 2012
    ..CD spectroscopy performed on these mixtures points to a preference for alternating self-assemblies of fluorinated and chiral hydrocarbon discotics...
  89. doi Quantitative assessment of hydrocarbon contamination in soil using reflectance spectroscopy: a "multipath" approach
    GUY SCHWARTZ
    The Porter School of Environmental Studies, Tel Aviv University, Tel Aviv 6997801, Israel
    Appl Spectrosc 67:1323-31. 2013
    ..The use of the "all possibilities" system proved to be mandatory for efficient optimal modeling of reflectance spectroscopy data. ..
  90. doi Caging of Cl atoms from photodissociation of CF2Cl2 in clusters
    Viktoriya Poterya
    J Heyrovsky Institute of Physical Chemistry v v i, Academy of Sciences of the Czech Republic, Dolejskova 3, 18223 Prague, Czech Republic
    Phys Chem Chem Phys 16:421-9. 2014
    ..In the latter case (ii) only the caged Cl fragments are observed...
  91. ncbi Intracavity sensing via compliance voltage in an external cavity quantum cascade laser
    Mark C Phillips
    Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Opt Lett 37:2664-6. 2012
    ..The technique is characterized and used to measure the absorption spectrum of water vapor and Freon-134a...
  92. ncbi Comparison of 24 h averaged VOC monitoring results for residential indoor and outdoor air using Carbopack X-filled diffusive samplers and active sampling--a pilot study
    William A McClenny
    National Exposure Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    J Environ Monit 8:263-9. 2006
    ..Agreement between the two sampling approaches indicates that the prediction of approximately constant diffusive sampling rates based on previous laboratory studies is valid under the field conditions...
  93. ncbi Quantitative evaluation of the performance of an industrial benchtop enclosing hood
    Xinjian Kevin He
    Industrial and Management Systems Engineering, College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, USA
    J Occup Environ Hyg 10:409-18. 2013
    ..However, the customized sash reduced exposures to less than the detection limit of 0.1 ppm, so a similar sash should be considered when feasible. The hood face velocity should be at least 150 ft/min if a sash is not used...
  94. ncbi Loss of Hoogsteen pairing ability upon N1 adenine platinum binding
    Kathrin S Schmidt
    Fachbereich Chemie, Universitat Dortmund, 44221 Dortmund, Germany
    Inorg Chem 41:2855-63. 2002
    ..With regard to mixtures of 2 and ChmTH in chloroform, this implies that ion pair formation between the cation of 2 and NO(3)(-) may be responsible for the lack of any measurable Hoogsteen pairing in this solvent...
  95. ncbi Adolescent inhalant abuse: environments of use
    E L McGarvey
    Department of Psychiatric Medicine, University of Virginia, Charlottesville 22908, USA
    Am J Drug Alcohol Abuse 25:731-41. 1999
    ..The five substances most frequently used as inhalants include gasoline (by 57.4%), Freon (40.45%), butane lighter fluid (38.3%), glue (29.8%), and nitrous oxide (23.4%). There were no gender differences for use of other products...
  96. ncbi Evaluation of the butter flavoring chemical diacetyl and a fluorochemical paper additive for mutagenicity and toxicity using the mammalian cell gene mutation assay in L5178Y mouse lymphoma cells
    Paul Whittaker
    Center for Food Safety and Applied Nutrition, Food and Drug Administration, 5100 Paint Branch Parkway, HFS 717, College Park, MD 20740 3835, United States
    Food Chem Toxicol 46:2928-33. 2008
    ..The increase in the frequency of small colonies in the assay with diacetyl indicates that diacetyl causes damage to multiple loci on chromosome 11 in addition to functional loss of the thymidine kinase locus...
  97. ncbi Enantioselective electrophilic trifluoromethylation of beta-keto esters with Umemoto reagents induced by chiral nonracemic guanidines
    Shun Noritake
    Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa Ku, Nagoya 466 8555, Japan
    Org Biomol Chem 7:3599-604. 2009
    ..Despite the fact that the ees are still improvable, the model reported in this work could spark the imagination of chemists to design new chiral bases to improve the stereochemical outcome...
  98. ncbi A comparative study of human skin thermal response to sapphire contact and cryogen spray cooling
    B Anvari
    Department of Engineering, Harvey Mudd College, Claremont, CA 91711, USA
    IEEE Trans Biomed Eng 45:934-41. 1998
    ....
  99. ncbi Tautomeric equilibria of 3-formylacetylacetone: low-temperature NMR spectroscopy and ab initio calculations
    Eline M Basilio Janke
    Institut fur Chemie, Freie Universitat Berlin, Takustrasse 3, D 14195 Berlin, Germany
    J Org Chem 74:4878-81. 2009
    ..This experimentally observed tautomeric distribution of 3-formylacetylacetone is correctly reproduced by continuum solvated DFT calculations...
  100. ncbi Friedreich's Ataxia: from the (GAA)n repeat mediated silencing to new promising molecules for therapy
    Daniele Marmolino
    Laboratoire de Neurologie Expérimentale, Hopital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Cerebellum 8:245-59. 2009
    ..Recently, several drugs have been assessed for their ability to increase the amount of cellular frataxin, including human recombinant erythropoietin, histone deacetylase inhibitors, and the PPAR-gamma agonists...
  101. ncbi Neuropsychological dose effects of a freon, trifluoromethane (FC-23), compared to N2O
    A A Rahill
    Department of Neurology, Henry Ford Hospital, Detroit, MI, USA
    Neurotoxicol Teratol 20:617-26. 1998
    ..This study indicated that FC-23 is not inert and that humans do not tolerate concentrations suitable for current MRI technology. NP and subjective data assisted in characterizing the sedative effect of FC-23...

Research Grants2

  1. Chemotherapy with injectable microdroplets
    FRANCESCO D ERRICO; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  2. SYNCHRONOUS TRACER INJECTION FOR PULMONARY PARAMETERS
    Justin Clark; Fiscal Year: 1980
    ..A portable unit will be built using a three channel gas chromatograph as the anaylzer, to provide sufficient sensitivity for measuring the low concentrations compatible with continuous breathing of the tracer gases...