carbon tetrachloride

Summary

Summary: A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

Top Publications

  1. ncbi Modeling liver fibrosis in rodents
    Christothea Constandinou
    University of Southampton, Southampton General Hospital, Southampton, UK
    Methods Mol Med 117:237-50. 2005
  2. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
  3. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
  4. ncbi Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    Suguru Oyagi
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871 Japan
    J Hepatol 44:742-8. 2006
  5. ncbi Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
  6. ncbi Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Department of Public Health, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Toxicology 189:113-27. 2003
  7. ncbi Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation
    Jia Xiao
    Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region
    J Ethnopharmacol 139:462-70. 2012
  8. ncbi Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
    K Kovalovich
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hepatology 31:149-59. 2000
  9. pmc Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
    Ogyi Park
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 49:1683-94. 2009
  10. ncbi Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model
    Jing hua Wang
    Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 22 5 Daeheung dong, Jung Gu, Daejeon 301 704, Republic of Korea
    J Ethnopharmacol 140:179-85. 2012

Detail Information

Publications347 found, 100 shown here

  1. ncbi Modeling liver fibrosis in rodents
    Christothea Constandinou
    University of Southampton, Southampton General Hospital, Southampton, UK
    Methods Mol Med 117:237-50. 2005
    ..Mechanistic studies using gene knockout and transgenic animals can also be established using CCl(4). Together these models have provided unparalleled insights into the mechanisms underlying hepatic fibrosis...
  2. pmc Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair
    Jeremy S Duffield
    Medical Research Council Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    J Clin Invest 115:56-65. 2005
    ..b>Carbon tetrachloride---induced liver fibrosis revealed scar-associated macrophages that persisted throughout recovery...
  3. ncbi Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model
    Lutz W D Weber
    Institute of Toxicology, GSF National Research Center for Environment and Health, Munich, P O Box 1129, D 85758 Neuherberg FRG
    Crit Rev Toxicol 33:105-36. 2003
    The use of many halogenated alkanes such as carbon tetrachloride (CCl4), chloroform (CHCl3) or iodoform (CHI3), has been banned or severely restricted because of their distinct toxicity...
  4. ncbi Therapeutic effect of transplanting HGF-treated bone marrow mesenchymal cells into CCl4-injured rats
    Suguru Oyagi
    Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871 Japan
    J Hepatol 44:742-8. 2006
    ..Here, we transplanted bone marrow-derived mesenchymal cells (BMMCs) to test their effect in liver-injured rats...
  5. ncbi Transplantation of bone marrow cells reduces CCl4-induced liver fibrosis in mice
    Isao Sakaida
    Department of Gastroenterology and Hepatology, School of Medicine, Yamaguchi University, Yamaguchi, Japan
    Hepatology 40:1304-11. 2004
    ..BMCs of green fluorescent protein (GFP) mice were transplanted into 4-week carbon tetrachloride (CCl4)-treated C57BL6 mice through the tail vein, and the mice were treated for 4 more weeks with CCl4 (..
  6. ncbi Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients
    Samar Basu
    Section of Geriatrics and Clinical Nutrition Research, Department of Public Health, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Toxicology 189:113-27. 2003
    Hepatic injury through carbon tetrachloride (CCl(4)) induced lipid peroxidation is well known and has been extensively used in the experimental models to understand the cellular mechanisms behind oxidative damage and further to evaluate ..
  7. ncbi Lycium barbarum polysaccharides protect mice liver from carbon tetrachloride-induced oxidative stress and necroinflammation
    Jia Xiao
    Department of Anatomy, The University of Hong Kong, Hong Kong Special Administrative Region
    J Ethnopharmacol 139:462-70. 2012
    ..Lycium barbarum has been used as a traditional Chinese medicine to nourish liver, kidneys and the eyes...
  8. ncbi Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
    K Kovalovich
    Department of Genetics, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA
    Hepatology 31:149-59. 2000
    ..Following acute carbon tetrachloride (CCl(4)) treatment, we found that IL-6-/- mice developed increased hepatocellular injury and defective ..
  9. pmc Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride
    Ogyi Park
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Hepatology 49:1683-94. 2009
    ..Here we show that iNKT-deficient mice are more susceptible to carbon tetrachloride (CCl(4))-induced acute liver injury and inflammation...
  10. ncbi Antifibrotic effects of Artemisia capillaris and Artemisia iwayomogi in a carbon tetrachloride-induced chronic hepatic fibrosis animal model
    Jing hua Wang
    Liver and Immunology Research Center, Daejeon Oriental Hospital of Daejeon University, 22 5 Daeheung dong, Jung Gu, Daejeon 301 704, Republic of Korea
    J Ethnopharmacol 140:179-85. 2012
    ..Artemisia capillaris and Artemisia iwayomogi, both members of the Compositae family, have been indiscriminately used for various liver disorders as traditional hepatotherapeutic medicines in Korea for many years...
  11. pmc Role of fibroblast growth factor type 1 and 2 in carbon tetrachloride-induced hepatic injury and fibrogenesis
    Chundong Yu
    Department of Biochemistry and Biophysics, Texas A and M University, and the Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M University System Health Science Center, Houston, Texas 77030, USA
    Am J Pathol 163:1653-62. 2003
    ..a role in response to injury and fibrosis, we examined the impact of both acute and chronic exposure to carbon tetrachloride (CCl(4)) in the livers of FGF1- and FGF2-deficient mice...
  12. pmc Mouse model of carbon tetrachloride induced liver fibrosis: Histopathological changes and expression of CD133 and epidermal growth factor
    Tsutomu Fujii
    Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, USA
    BMC Gastroenterol 10:79. 2010
    ..The carbon tetrachloride (CCl4)-induced mouse model has been historically relied upon to study liver injury and regeneration...
  13. ncbi Ferulic acid protects against carbon tetrachloride-induced liver injury in mice
    Hyo Yeon Kim
    School of Pharmacy, Sungkyunkwan University, Suwon 440 746, Republic of Korea
    Toxicology 282:104-11. 2011
    ..Here, we have investigated the hepatoprotective effect of FA against carbon tetrachloride (CCl(4))-induced acute liver injury...
  14. ncbi (-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R
    Yoichi Yasuda
    Department of Internal Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    Chem Biol Interact 182:159-64. 2009
    ..which inhibits the activation of several types of RTKs, on the development of rat liver fibrosis induced by carbon tetrachloride (CCl4). Drinking water with 0...
  15. ncbi Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage
    Steven Dooley
    Department of Medicine II, Gastroenterology and Hepatology, University Hospital, Mannheim, Germany
    Gastroenterology 135:642-59. 2008
    ..The profibrogenic role of transforming growth factor (TGF)-beta in liver has mostly been attributed to hepatic stellate cell activation and excess matrix synthesis. Hepatocytes are believed to contribute to increased rates of apoptosis...
  16. ncbi Effects of Sho-saiko-to extract and its components, Baicalin, baicalein, glycyrrhizin and glycyrrhetic acid, on pharmacokinetic behavior of salicylamide in carbon tetrachloride intoxicated rats
    Zenei Taira
    Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima 770 8514, Japan
    Food Chem Toxicol 42:803-7. 2004
    ..Sho-saiko-to extract and its components were shown to suppress acute hepatic injury induced by CCl4, and to bring about an early recovery in liver function...
  17. ncbi Epigallocatechin-3-gallate (EGCG) reduces liver inflammation, oxidative stress and fibrosis in carbon tetrachloride (CCl4)-induced liver injury in mice
    George L Tipoe
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, SAR
    Toxicology 273:45-52. 2010
    ..The protective effect of EGCG may in part be a consequence of the reduction in oxidative stress and the pro-inflammatory response...
  18. ncbi Antioxidative and hepatoprotective effects of Antrodia camphorata extract
    George Hsiao
    Department of Pharmacology and Graduate Institute of Medical Sciences, Taipei Medical University, 250 Wu Hsing Street, Taipei 110, Taiwan
    J Agric Food Chem 51:3302-8. 2003
    ..camphorata extracts to protect against oxidative stress in vitro and against carbon tetrachloride (CCl(4))-induced hepatic injury in vivo. An extract of A...
  19. ncbi Hydrodynamic gene delivery of interleukin-22 protects the mouse liver from concanavalin A-, carbon tetrachloride-, and Fas ligand-induced injury via activation of STAT3
    Hongna Pan
    Section on Liver Biology, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA
    Cell Mol Immunol 1:43-9. 2004
    ..significantly protects against liver injury, necrosis, and apoptosis induced by administration of Con A, carbon tetrachloride (CCl4), or the Fas agonist Jo-2 mAb...
  20. ncbi The role of Smad3 in mediating mouse hepatic stellate cell activation
    B Schnabl
    Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Hepatology 34:89-100. 2001
    ....
  21. ncbi Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties
    Rajesh Bhattacharjee
    Department of Chemistry, Bose Institute, 93 1, Acharya Prafulla Chandra Road, Kolkata 700009, West Bengal, India
    Food Chem Toxicol 45:817-26. 2007
    ..niruri was investigated against carbon tetrachloride (CCl(4)) induced liver damage in vivo. Protein isolate of P...
  22. ncbi Antioxidant and antiapoptotic effects of capsaicin against carbon tetrachloride-induced hepatotoxicity in rats
    Memy H Hassan
    Department of Pharmacy, Faculty of Health Sciences, Taibah University, Saudi Arabia
    Toxicol Ind Health 28:428-38. 2012
    The aim of the study was to evaluate the potential hepatoprotective utility of capsaicin against carbon tetrachloride (CCl₄)-induced liver injury and to explore the possible mechanisms whereby this agent mediated its beneficial effects...
  23. ncbi Evaluation of the antioxidant, anti-inflammatory and hepatoprotective properties of vanillin in carbon tetrachloride-treated rats
    Mohamed Makni
    Food Processing Department, ISET, BP 377, 9100 Sidi Bouzid, Tunisia
    Eur J Pharmacol 668:133-9. 2011
    ..These findings suggest that the antioxidant and anti-inflammatory effects of vanillin against CCl(4)-induced acute liver injury may involve its ability to block CCl(4)-generated free radicals...
  24. ncbi Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats
    Mohamed A Morsy
    Department of Pharmacology, El Minia University, El Minia, Egypt
    J Physiol Biochem 68:29-35. 2012
    ..the present work, the effectiveness of curcumin, α-lipoic acid, and N-acetylcysteine in protecting against carbon tetrachloride (CCl(4))-induced liver fibrosis as well as the mechanism(s) implicated in this protective effect was ..
  25. ncbi The role of tumor necrosis factor-alpha in liver toxicity, inflammation, and fibrosis induced by carbon tetrachloride
    P P Simeonova
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA
    Toxicol Appl Pharmacol 177:112-20. 2001
    ..We examined the role of TNFalpha in transgenic mice deficient in TNF receptors (TNFR) utilizing carbon tetrachloride (CCl(4)) as a model hepatotoxic agent that allowed for the evaluation of necrosis, inflammation, and ..
  26. ncbi The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2
    Hyeong Seon Lee
    Department of Smart Foods and Drugs, Graduate School, Inje University, Gimhae, Gyeongnam 621 749, South Korea
    J Microbiol Biotechnol 20:1331-8. 2010
    ..extract (CLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats...
  27. ncbi Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation, and liver fibrosis induced by carbon tetrachloride in mice
    H Louis
    Department of Gastroenterology and Hepatopancreatology, Brussels, Belgium
    Hepatology 28:1607-15. 1998
    ..cytokine interleukin-10 (IL-10) was investigated in the mouse model of liver injury induced by carbon tetrachloride (CCl4)...
  28. ncbi Protective effects of the flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. on carbon tetrachloride-induced hepatotoxicity in rats
    Daozong Xia
    College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, No 548, Binwen Road, Hangzhou 310053, Zhejiang Province, China
    J Membr Biol 246:479-85. 2013
    ..SGF) on carbon tetrachloride (CCl₄)-induced hepatotoxicity in rats...
  29. ncbi Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress
    Karina Reyes-Gordillo
    Seccion Externa de Farmacologia, CINVESTAV IPN, Apdo Postal 14 740 México 07000, D F Mexico
    Biochim Biophys Acta 1770:989-96. 2007
    Curcumin, an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Acute hepatotoxicity was induced by oral administration of CCl4 (4 g/kg, p.o.)...
  30. pmc Protective effects of Launaea procumbens on rat testis damage by CCl4
    Rahmat Ali Khan
    Department of Biotechnology, Faculty of Biological Sciences, University of Science and Technology Bannu, Bannu, KPK, Pakistan
    Lipids Health Dis 11:103. 2012
    ..In the present study protective effects of methanolic extract of Launaea procumbens (LPME) was evaluated against CCl4-induced oxidative damages in rat testis...
  31. ncbi Aliskiren attenuates chronic carbon tetrachloride-induced liver injury in mice
    Kuei Chuan Lee
    Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan
    Eur J Clin Invest 42:1261-71. 2012
    ..Increased angiotensin II (Ang II) plays an important role in liver inflammation and fibrogenesis. Chronic administration of aliskiren, a newly developed direct renin inhibitor, decreases Ang II in the hypertensive patients and animals...
  32. ncbi Cell transplantation of adipose tissue-derived stem cells in combination with heparin attenuated acute liver failure in mice
    Hiroshi Yukawa
    Department of Advanced Medicine in Biotechnology and Robotics, Nagoya University Graduate School of Medicine, Nagoya 461 0047, Japan
    Cell Transplant 18:611-8. 2009
    ..stem cells (ASCs) in combination with heparin transplantation on acute liver failure mice with carbon tetrachloride (CCl(4)) injection was investigated. CCl(4) is a well-known hepatotoxin and induces hepatic necrosis...
  33. pmc Protection of the liver against CCl4-induced injury by intramuscular electrotransfer of a kallistatin-encoding plasmid
    Yong Diao
    Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, Fujian Province, China
    World J Gastroenterol 17:111-7. 2011
    To investigate the effect of transgenic expression of kallistatin (Kal) on carbon tetrachloride (CCl(4))-induced liver injury by intramuscular (im) electrotransfer of a Kal-encoding plasmid formulated with poly-L-glutamate (PLG).
  34. ncbi Anti-fibrotic effect of chorionic plate-derived mesenchymal stem cells isolated from human placenta in a rat model of CCl(4)-injured liver: potential application to the treatment of hepatic diseases
    Min Jae Lee
    School of Veterinary Medicine, Kangwon National University, Chuncheon, Kangwon Do, Republic of Korea
    J Cell Biochem 111:1453-63. 2010
    ..plate-derived mesenchymal stem cells (CP-MSCs) isolated from human placenta and transplanted into rats with carbon tetrachloride (CCl(4))-injured livers...
  35. ncbi Molecular process in acute liver injury and regeneration induced by carbon tetrachloride
    Makoto Taniguchi
    Division of Molecular Biology, Department of Molecular and Cellular Biology, School of Life Sciences, Tottori University Faculty of Medicine, 86 Nishimachi, Yonago 683 8503, Japan
    Life Sci 75:1539-49. 2004
    Injection of carbon tetrachloride (CCl4) intraperitoneally into model animals induces acute liver injury mediated by reactive oxygen species (ROS) as normal metabolites in hepatocytes...
  36. ncbi Propolis protects CYP 2E1 enzymatic activity and oxidative stress induced by carbon tetrachloride
    Monika Bhadauria
    School of Studies in Zoology, Jiwaji University, Gwalior, 474011 MP, India
    Mol Cell Biochem 302:215-24. 2007
    Induction of CYP 2E1 by carbon tetrachloride (CCl(4)) is one of the central pathways by which CCl(4) generates oxidative stress in hepatocytes...
  37. ncbi Mesenchymal stem cell infusion therapy in a carbon tetrachloride-induced liver fibrosis model affects matrix metalloproteinase expression
    Vahideh Rabani
    Department of Stem Cells and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
    Cell Biol Int 34:601-5. 2010
    ..In conclusion, MSCs can enhance recovery of a CCl(4)-injured mouse liver through their influence in reducing collagen deposition by possibly affecting expression of MMPs...
  38. ncbi Neutralization of CXCL10 accelerates liver regeneration in carbon tetrachloride-induced acute liver injury
    Hiroyuki Yoneyama
    Laboratory of Stem Cell Dynamism, Stelic Institute of Regenerative Medicine, Stelic Institute and Co, 1 9 15 Higashi azabu, Mihato ku, Tokyo, Japan
    Med Mol Morphol 40:191-7. 2007
    ..We report here that the chemokine CXCL10 regulates hepatic tissue remodeling in a carbon tetrachloride (CCl(4))-induced acute liver injury in mice...
  39. pmc Protective effect of recombinant human IL-1Ra on CCl4-induced acute liver injury in mice
    Run Zhi Zhu
    Shanghai Municipality Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
    World J Gastroenterol 16:2771-9. 2010
    To evaluate the effects of positive regulation of recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury in mice induced by carbon tetrachloride (CCl(4)).
  40. ncbi Effects of silymarin nanoemulsion against carbon tetrachloride-induced hepatic damage
    Rabea Parveen
    Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110062, India
    Arch Pharm Res 34:767-74. 2011
    ..parameters and histopathological properties of the nanoemulsion formulation of silymarin against carbon tetrachloride (CCl(4))-induced hepatotoxicity...
  41. pmc Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice
    Michele T Pritchard
    Department of Pathobiology, Cleveland Clinic, Cleveland, OH 44195, USA
    J Hepatol 53:655-62. 2010
    ..Here, we tested the hypothesis that Egr-1 is beneficial after toxic liver injury...
  42. pmc Emodin protects rat liver from CCl(4)-induced fibrogenesis via inhibition of hepatic stellate cells activation
    Miao Xian Dong
    The Institute of Medicine, Qiqihar Medical University, JianHua District, Qiqihar, Heilongjiang Province, China
    World J Gastroenterol 15:4753-62. 2009
    To investigate the role of emodin in protecting the liver against fibrogenesis caused by carbon tetrachloride (CCl(4)) in rats and to further explore the underlying mechanisms.
  43. ncbi Melatonin ameliorates carbon tetrachloride-induced hepatic fibrogenesis in rats via inhibition of oxidative stress
    Hua Wang
    Institute of Clinical Pharmacology, Anhui Medical University, Hefei 230032, China
    Life Sci 77:1902-15. 2005
    ..The aim of this study was to investigate the protective effects of administration of melatonin in rats with carbon tetrachloride-induced fibrosis for 6 weeks...
  44. ncbi Acute renal failure induced by carbon tetrachloride in rats with hepatic cirrhosis
    Fernando Jaramillo-Juárez
    Universidad Autonoma de Aguascalientes, Aguascalientes, Mexico
    Ann Hepatol 7:331-8. 2008
    ..Cirrhosis was induced with carbon tetrachloride by chronic administration...
  45. ncbi Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats
    Yibin Feng
    School of Chinese Medicine, The University of Hong Kong, Pokfulam, Hong Kong, PR China
    J Ethnopharmacol 138:683-90. 2011
    ..In the present study, the protection of CRAE on chronic liver damage induced by carbon tetrachloride (CCl(4)) in rats and its related mechanism were explored.
  46. ncbi Disruption of the Smad7 gene enhances CCI4-dependent liver damage and fibrogenesis in mice
    Jafar Hamzavi
    Molecular Alcohol Research in Gastroenterology, Department of Medicine II, Faculty of Medicine at Mannheim, University of Heidelberg, Germany
    J Cell Mol Med 12:2130-44. 2008
    ..To obtain insight into Smad7-depend-ent protective effects, chronic liver damage was induced in mice by carbon tetrachloride (CCI4) administration...
  47. ncbi Role of IL-6 trans-signaling in CCl₄induced liver damage
    Jessica Gewiese-Rabsch
    Institute of Biochemistry, Christian Albrechts University of Kiel, Kiel, Germany
    Biochim Biophys Acta 1802:1054-61. 2010
    ..We conclude that IL-6 trans-signaling via the soluble IL-6R is important for the physiologic response of the liver to CCl₄ induced chemical damage...
  48. ncbi Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats
    Narasimhanaidu Kamalakkannan
    Department of Biochemistry, Faculty of Science, Rajah Muthiah Medical College, Annamalai University, Annamalainagar 608002, Tamil Nadu, India
    Basic Clin Pharmacol Toxicol 97:15-21. 2005
    ..diferuloyl methane) and its analogue [bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione] (BDMC-A) on carbon tetrachloride-induced hepatotoxicity in rats...
  49. ncbi Hydroxysafflor yellow A protects against chronic carbon tetrachloride-induced liver fibrosis
    Yingbo Zhang
    The Institute of Medicine, Qiqihar Medical University, Qiqihar 161006, China
    Eur J Pharmacol 660:438-44. 2011
    ..In the present study, we investigated the effects of HSYA in rats with carbon tetrachloride (CCl4)-induced liver fibrosis...
  50. ncbi Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride
    Chao Ying Lee
    School of Pharmacy, China Medical University, Taichung 404, Taiwan, R O C
    Am J Chin Med 34:471-82. 2006
    ..s. urinaria and GA correlate with a reduction in liver infiltration and focal necrosis observed using histological methods, these data demonstrate that P. acidus and P. urinaria L.s. urinaria are hepatoprotective and antioxidant agents...
  51. ncbi Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats
    S Sreelatha
    Department of Chemistry and Biosciences, SASTRA University, SRC Campus, Kumbakonam, Tamilnadu, India
    Food Chem Toxicol 47:702-8. 2009
    ..Based on these results, it was observed that C. sativum extract protects liver from oxidative stress induced by CCl(4) and thus helps in evaluation of traditional claim on this plant...
  52. ncbi The involvement of Kupffer cells in carbon tetrachloride toxicity
    M J Edwards
    Department of Pharmacology, University of North Carolina, Chapel Hill 27599 7365
    Toxicol Appl Pharmacol 119:275-9. 1993
    b>Carbon tetrachloride (CCl4) is a classical pericentral hepatotoxicant; however, precise details of its mechanism of action remain unknown...
  53. ncbi Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats
    J H Tsai
    Basic Medical Science Education Center, College of Medicine and Health, Fooyin University, Kaohsiung, Taiwan
    J Viral Hepat 15:508-14. 2008
    ..However, the therapeutic effects of silymarin remain undefined. Carbon tetrachloride (CCl4) is a xenobiotic used extensively to induce oxidative stress and is one of the most widely used ..
  54. ncbi Hepato and reno protective action of Calendula officinalis L. flower extract
    Korengath Chandran Preethi
    Department of Biochemistry Amala Cancer Research Centre, Amala Nagar, Thrissur, India, 680 555
    Indian J Exp Biol 47:163-8. 2009
    ..Extract has been found to contain several carotenoids of which lutein, zeaxanthin and lycopene predominates. Possible mechanism of action of the flower extract may be due to its antioxidant activity and reduction of oxygen radicals...
  55. ncbi Bone marrow-derived mesenchymal stem cells protect against experimental liver fibrosis in rats
    Dong Chang Zhao
    Center for Stem Cell Biology and Tissue Engineering, Sun Yat Sen University, 74 Zhongshan Road II, Guangzhou 510080, Guangdong Province, China
    World J Gastroenterol 11:3431-40. 2005
    ..These results provide a clue to treatment of liver fibrosis. The aim of this study was to investigate the effect of infusion of bone marrow (BM)-derived MSCs on the experimental liver fibrosis in rats...
  56. ncbi Transplantation of human amnion epithelial cells reduces hepatic fibrosis in immunocompetent CCl₄-treated mice
    Ursula Manuelpillai
    Centre for Reproduction and Development, Monash Institute of Medical Research, Monash University, Clayton, Victoria, Australia
    Cell Transplant 19:1157-68. 2010
    ..isolated from term delivered placenta, into immunocompetent C57/BL6 mice at week 2 of a 4-week regimen of carbon tetrachloride (CCl₄) exposure to induce liver fibrosis...
  57. ncbi A synthetic peptide from transforming growth factor beta type III receptor inhibits liver fibrogenesis in rats with carbon tetrachloride liver injury
    Ignacio José Ezquerro
    Departamento de Medicina Interna, Universidad de Navarra, Pamplona, Spain
    Cytokine 22:12-20. 2003
    ..These results suggest that short synthetic peptides derived from TGF-beta1 type III receptor may be of value in reducing liver fibrosis in chronic liver injury...
  58. ncbi The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis
    Maria J Perugorria
    Division of Hepatology and Gene Therapy, CIMA, University of Navarra, Pamplona, Spain
    Hepatology 48:1251-61. 2008
    ..AR also stimulated cell proliferation and exerted a potent antiapoptotic effect on isolated fibrogenic cells...
  59. ncbi The hepatoprotective effects of Limonium sinense against carbon tetrachloride and beta-D-galactosamine intoxication in rats
    Shang Shing Chaung
    Department of Pharmacy, Kaohsiung Municipal Ta Tung Hospital, Kaohsiung, Taiwan, Republic of China
    Phytother Res 17:784-91. 2003
    In the present study, the hepatoprotective action of Limonium sinense (Plumbaginaceae) was evident after carbon tetrachloride (CCl(4)) and beta-D-galactosamine (D-GalN), respectively, challenge in rats...
  60. pmc Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats
    Yu Ping Wang
    Department of Infectious Diseases, Guiyang Medical College, Guiyang 550004, Guizhou Province, China
    World J Gastroenterol 16:2657-63. 2010
    ..To investigate the effects of blueberry on hepatic fibrosis and NF-E2-related factor 2 (Nrf2) transcription factor in rats...
  61. ncbi Bone marrow-derived cells express matrix metalloproteinases and contribute to regression of liver fibrosis in mice
    Reiichi Higashiyama
    Liver Fibrosis Research Unit, Department of Community Health, Tokai University School of Medicine, Isehara, Japan
    Hepatology 45:213-22. 2007
    ..marrow (BM)-derived cells to the spontaneous regression of liver fibrosis, mice were treated with repeated carbon tetrachloride injections after hematopoietic reconstitution with enhanced green fluorescent protein (EGFP)-expressing BM ..
  62. ncbi The therapeutic potential of human umbilical mesenchymal stem cells from Wharton's jelly in the treatment of rat liver fibrosis
    Pei Chun Tsai
    Institute of Anatomy and Cell Biology, School of Medicine, National Yang Ming University, Taipei, Taiwan, Republic of China
    Liver Transpl 15:484-95. 2009
    We investigated the effect of human umbilical mesenchymal stem cells (HUMSCs) from Wharton's jelly on carbon tetrachloride (CCl4)-induced liver fibrosis in rats...
  63. ncbi Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats
    Cheng Liu
    Institute of Liver Diseases, Shuguang Hospital, Shanghai, People s Republic of China
    Lab Invest 90:1805-16. 2010
    ..Hepatic fibrosis was induced in rats by dimethylnitrosamine (DMN) or carbon tetrachloride (CCl4) treatment...
  64. ncbi Newly proposed fibrosis staging criterion for assessing carbon tetrachloride- and albumin complex-induced liver fibrosis in rodents
    Xin Yan Zhao
    Liver Research Center, Beijing Friendship Hospital, Capital Medical University
    Pathol Int 58:580-8. 2008
    ..Liver fibrosis was induced by carbon tetrachloride (CCl(4)) or albumin antigen-antibody complex in Balb/C mice or Wistar rats...
  65. ncbi Systemic infusion of FLK1(+) mesenchymal stem cells ameliorate carbon tetrachloride-induced liver fibrosis in mice
    Baijun Fang
    Sino American Collaborative Laboratory, State Key Lab of Experimental Haematology, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Tissue Engineering Center, Chinese Academy of Medical Sciences, Tianjin, China
    Transplantation 78:83-8. 2004
    ..This study was designed to evaluate the effect of Flk1 MSCs from murine BM (termed here Flk1 mMSCs) on fibrosis formation induced by carbon tetrachloride (CCl4).
  66. ncbi Carbon tetrachloride-induced nephrotoxicity and protective effect of betaine in Sprague-Dawley rats
    Feral Ozturk
    Department of Histology Embryology, Inonu University Faculty of Medicine, Malatya, Turkey
    Urology 62:353-6. 2003
    ..the changes in the antioxidative defense enzymes and to detect the alterations of renal microscopy after carbon tetrachloride (CCl4) administration in rats and to investigate the possible protective effects of betaine against CCl4-..
  67. ncbi Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride
    P Muriel
    Departamento de Farmacologia y Toxicologia, Centro de Investigación y de Estudios Avanzados del I P N, Mexico, DF, Mexico
    Biochem Pharmacol 56:773-9. 1998
    ..These results suggest that NO protects the liver against oxidative injury, because NO inhibition by L-NAME or AG increased lipid peroxidation and the other markers of liver injury studied herein...
  68. ncbi Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis
    Jonathan A Fallowfield
    Liver Research Group, Southampton General Hospital, Southampton, United Kingdom
    J Immunol 178:5288-95. 2007
    ..Thus, SAMs selectively, during resolution of fibrosis induce and use the major collagenase MMP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver...
  69. ncbi Lisosan G, a powder of grain, does not interfere with the drug metabolizing enzymes and has a protective role on carbon tetrachloride-induced hepatotoxicity
    Vincenzo Longo
    Laboratory of Pharmacogenetics and Drug Metabolism, Istituto di Fisiologia Clinica, CNR, Via Moruzzi, 1, Pisa, 56100, Italy
    Biotechnol Lett 29:1155-9. 2007
    ..of the antioxidative property of Lisosan G was also confirmed when it was administered in vivo to carbon tetrachloride (CCl(4))-intoxicated rats...
  70. ncbi Regeneration of coenzyme Q9 redox state and inhibition of oxidative stress by Rooibos tea (Aspalathus linearis) administration in carbon tetrachloride liver damage
    J Kucharska
    Pharmacobiochemical Laboratory, School of Medicine, Comenius University, Hlboka 7, 811 05 Bratislava, Slovak Republic
    Physiol Res 53:515-21. 2004
    ..tea (Aspalathus linearis) on liver antioxidant status and oxidative stress was investigated in rat model of carbon tetrachloride-induced liver damage. Synthetic antioxidant N-acetyl-L-cysteine (NAC) was used for comparison...
  71. ncbi Hepatoprotection of chlorella against carbon tetrachloride-induced oxidative damage in rats
    Hsin Yi Peng
    Department of Food and Nutrition, Providence University, Shalu, Taichung, Taiwan, P R C
    In Vivo 23:747-54. 2009
    The effects of 80% ethanolic chlorella extracts (GPE) on carbon tetrachloride (CCl(4))-induced hepatic damage were investigated in Sprague-Dawley rats. The rats were orally treated with GPE (0.5 g/kg body weight) or silymarin (0...
  72. ncbi Protective effect of red beetroot against carbon tetrachloride- and N-nitrosodiethylamine-induced oxidative stress in rats
    Małgorzata Kujawska
    Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland
    J Agric Food Chem 57:2570-5. 2009
    ..effect of beetroot juice in a model of oxidative stress induced by N-nitrosodiethylamine (NDEA) and carbon tetrachloride (CCl(4)). Male Wistar rats were treated with beetroot juice per os, 8 mL/kg/day for 28 days, and a single i...
  73. ncbi The antioxidant and antifibrogenic effects of the glycosaminoglycans hyaluronic acid and chondroitin-4-sulphate in a subchronic rat model of carbon tetrachloride-induced liver fibrogenesis
    Giuseppe M Campo
    Department of Biochemical, Physiological and Nutritional Sciences, School of Medicine, University of Messina, Policlinico Universitario, 98125, Italy
    Chem Biol Interact 148:125-38. 2004
    ..They also confirm that HYA and C4S may exert antioxidant mechanism, while reduction of TIMPs expression suggests that GAGs may influence MMPs and TIMPs imbalance in liver fibrosis...
  74. ncbi Enhanced carbon tetrachloride-induced liver fibrosis in mice lacking adiponectin
    Yoshihiro Kamada
    Department of Internal Medicine and Molecular Science, Osaka University, Graduate School of Medicine, Suita, Japan
    Gastroenterology 125:1796-807. 2003
    ..Adiponectin suppresses the proliferation and migration of vascular smooth muscle cells, whose characteristics are similar to those of hepatic stellate cells. Adiponectin could have biological significances in liver fibrosis...
  75. ncbi Protective effects of quercetin and quercetin-5',8-disulfonate against carbon tetrachloride-caused oxidative liver injury in mice
    Yanmang Cui
    School of Pharmacy, Fourth Military Medical University, Xi an 710032, China
    Molecules 19:291-305. 2013
    ....
  76. ncbi Hepatoprotective effects of 18beta-glycyrrhetinic acid on carbon tetrachloride-induced liver injury: inhibition of cytochrome P450 2E1 expression
    Hye Gwang Jeong
    Department of Pharmacy and Research Center for Proteineous Materials, Chosun University, 375 Seosuk dong, Kwangju 501 759, South Korea
    Pharmacol Res 46:221-7. 2002
    ..effects of 18beta-glycyrrhetinic acid (GA), the aglycone of glycyrrhizin (GL) derived from licorice, on carbon tetrachloride-induced hepatotoxicity and the possible mechanisms involved in this protection were investigated in mice...
  77. ncbi Effects of Ag(I), Au(III), and Cu(II) on the reductive dechlorination of carbon tetrachloride by green rust
    Edward J O'Loughlin
    Air Force Research Laboratory, AFRL MLQL, 139 Barnes Drive, Tyndall Air Force Base, Florida, 32403 5323, USA
    Environ Sci Technol 37:2905-12. 2003
    ..Reductive dechlorination of carbon tetrachloride (CT) was examined in aqueous suspensions of GR amended with Ag(I), Au(III), or Cu(II)...
  78. ncbi Tanshinone IIA protects rat primary hepatocytes against carbon tetrachloride toxicity via inhibiting mitochondria permeability transition
    Bin Zhu
    Department of Pharmacy, Fudan University Cancer Hospital, Shanghai, China
    Pharm Biol 48:484-7. 2010
    ..carried out to investigate the possible mechanisms involved in the hepatoprotective effects of Tan IIA on carbon tetrachloride (CCl(4))-induced hepatocyte toxicity...
  79. pmc P2X7 receptor-NADPH oxidase axis mediates protein radical formation and Kupffer cell activation in carbon tetrachloride-mediated steatohepatitis in obese mice
    Saurabh Chatterjee
    Free Radical Metabolism Group, Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA
    Free Radic Biol Med 52:1666-79. 2012
    While some studies show that carbon tetrachloride-mediated metabolic oxidative stress exacerbates steatohepatitic-like lesions in obese mice, the redox mechanisms that trigger the innate immune system and accentuate the inflammatory ..
  80. ncbi The molecular mechanisms of the hepatoprotective effect of gomisin A against oxidative stress and inflammatory response in rats with carbon tetrachloride-induced acute liver injury
    Ryutaro Teraoka
    Graduate School of Pharmaceutical Sciences, Graduate School of Musashino University, Tokyo, Japan
    Biol Pharm Bull 35:171-7. 2012
    ..a hepatoprotective effect, focusing on its antioxidant and anti-inflammatory effects using rats with carbon tetrachloride (CCl(4))-induced acute liver injury...
  81. ncbi Preventive and therapeutic effects of oleuropein against carbon tetrachloride-induced liver damage in mice
    Robert Domitrovic
    Department of Chemistry and Biochemistry, School of Medicine, University of Rijeka, Rijeka, Croatia
    Pharmacol Res 65:451-64. 2012
    ..In this study, we have investigated the hepatoprotective activity of oleuropein in carbon tetrachloride (CCl(4))-induced liver injury in male BALB/cN mice...
  82. ncbi Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver
    Laetitia Knockaert
    INSERM, UMR 991, Liver Metabolisms and Cancer, Rennes, France
    Lab Invest 92:396-410. 2012
    Although carbon tetrachloride (CCl(4))-induced acute and chronic hepatotoxicity have been extensively studied, little is known about the very early in vivo effects of this organic solvent on oxidative stress and mitochondrial function...
  83. ncbi Carbon tetrachloride-induced hepatotoxicity and its amelioration by Agaricus blazei Murrill extract in a mouse model
    Jin Biou Chang
    Department of Pathology, National Defense Medical Center, Division of Clinical Pathology, Tri Service General Hospital, Taipei, Taiwan, ROC
    In Vivo 25:971-6. 2011
    ..the hepatoprotective effect of Agaricus blazei Murrill extract (ABM) against experimentally induced carbon tetrachloride (CCl(4)) toxicity in male BALB/c mice...
  84. ncbi Blackberry extract attenuates oxidative stress through up-regulation of Nrf2-dependent antioxidant enzymes in carbon tetrachloride-treated rats
    Byoung Ok Cho
    Korea Atomic Energy Research Institute, Jeongeup, Jeonbuk 580 185, Republic of Korea
    J Agric Food Chem 59:11442-8. 2011
    ..this study was to investigate the protective ability of blackberry extract (BE) against oxidative stress in carbon tetrachloride (CCl(4))-treated rats...
  85. ncbi Macrophage therapy for murine liver fibrosis recruits host effector cells improving fibrosis, regeneration, and function
    James A Thomas
    MRC Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Hepatology 53:2003-15. 2011
    ..Advanced liver fibrosis was induced in female mice by chronic administration of carbon tetrachloride. Unmanipulated, syngeneic macrophages, their specific BM precursors, or unfractionated BM cells were ..
  86. ncbi Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice
    Wei Jiang
    State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210093, PR China
    Biochem Biophys Res Commun 422:344-50. 2012
    We studied effects of L-theanine, a unique amino acid in tea, on carbon tetrachloride (CCl(4))-induced liver injury in mice...
  87. ncbi Acetyl-L-carnitine prevents carbon tetrachloride-induced oxidative stress in various tissues of Wistar rats
    Thangaraj Annadurai
    Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tamil Nadu, India
    J Physiol Biochem 67:519-30. 2011
    ..The present study was based on the hypothesis that ALCAR prevents carbon tetrachloride (CCl(4))-induced oxidative stress in vital tissues...
  88. ncbi Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice
    Jingyu Yang
    Department of Pharmacology, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
    J Agric Food Chem 58:6525-31. 2010
    ....
  89. ncbi Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection
    Thamirys Guimarães Marques
    School of Medicine, USP, Sao Paulo, Brazil
    Acta Cir Bras 27:589-94. 2012
    To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis.
  90. ncbi Branched-chain amino acid-enriched nutrients stimulate antioxidant DNA repair in a rat model of liver injury induced by carbon tetrachloride
    Kengo Ichikawa
    Regenerative Medicine Group, Center for Innovative and Translational Medicine, Department of Surgery at Kochi Medical School, Kochi University, Kohasu Okocho, Nankoku, Kochi, 783 8505, Japan
    Mol Biol Rep 39:10803-10. 2012
    ..Liver cirrhosis was induced in ten male Sprague-Dawley rats by administering carbon tetrachloride for 12 weeks...
  91. pmc S-allylmercaptocysteine reduces carbon tetrachloride-induced hepatic oxidative stress and necroinflammation via nuclear factor kappa B-dependent pathways in mice
    Jia Xiao
    Department of Anatomy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, L1 41, Laboratory Block, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China
    Eur J Nutr 51:323-33. 2012
    To study the protective effects and underlying molecular mechanisms of SAMC on carbon tetrachloride (CCl4)-induced acute hepatotoxicity in the mouse model.
  92. pmc Selenium supplementation decreases hepatic fibrosis in mice after chronic carbon tetrachloride administration
    Ming Ding
    Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2195, USA
    Biol Trace Elem Res 133:83-97. 2010
    ..The principal mechanisms for the decreased fibrosis are a lower number of collagen-producing stellate cells and increased collagen degradation...
  93. ncbi Protective effect of Diyarbakır watermelon juice on carbon tetrachloride-induced toxicity in rats
    Sevcan Altaş
    Dicle University, Faculty of Science, Chemistry Department, 21280 Diyarbakir, Turkey
    Food Chem Toxicol 49:2433-8. 2011
    ..Sürme) juice on lipid peroxidation states in rat liver, kidney and brain. In vivo administration of carbon tetrachloride (CCl(4)) once a week for 28 days caused a significant elevation of serum markers of liver damage, aspartate ..
  94. pmc FXR regulates liver repair after CCl4-induced toxic injury
    Zhipeng Meng
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, California 91010, USA
    Mol Endocrinol 24:886-97. 2010
    ..Here we show that FXR is essential to promote liver repair after carbon tetrachloride (CCl(4))-induced injury...
  95. ncbi Direct and indirect contribution of human embryonic stem cell-derived hepatocyte-like cells to liver repair in mice
    Dong Hun Woo
    Laboratory of Stem Cell Biology, Division of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, Republic of Korea
    Gastroenterology 142:602-11. 2012
    ..We investigated the direct and indirect roles of human embryonic stem cell-derived cells in liver repair in mice...
  96. pmc Negundoside, an irridiod glycoside from leaves of Vitex negundo, protects human liver cells against calcium-mediated toxicity induced by carbon tetrachloride
    Sheikh A Tasduq
    Experimental Toxicology Lab, Division of Pharmacology, Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu 180001, Jammu and Kashmir, India
    World J Gastroenterol 14:3693-709. 2008
    To evaluate the protective effect of 2'-p-hydroxybenzoylmussaenosidic acid [negundoside (NG), against carbon tetrachloride (CCl(4))-induced toxicity in HuH-7 cells.
  97. ncbi Hepatoprotective effects of phloridzin on hepatic fibrosis induced by carbon tetrachloride against oxidative stress-triggered damage and fibrosis in rats
    Gaigai Deng
    Hubei Key Laboratory of Natural Products Research and Development, China Three Gorges University, Yichang 443002, P R China
    Biol Pharm Bull 35:1118-25. 2012
    ..present study was to study the hepatoprotective effects of phloridzin (PHL) on hepatic fibrosis induced by carbon tetrachloride (CCl₄) in rats, on the basis of this investigation, the possible mechanism of PHL was elucidated...
  98. ncbi Gene expression profiles during hepatic stellate cell activation in culture and in vivo
    Samuele De Minicis
    Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 132:1937-46. 2007
    ..In this study, we determine gene expression changes in 3 different models of HSC activation and investigate whether HSC culture activation reproduces gene expression changes of HSC in vivo activation...
  99. ncbi Enhanced hepatic differentiation of mesenchymal stem cells after pretreatment with injured liver tissue
    Sadia Mohsin
    National Center of Excellence in Molecular Biology, 87 West Canal Bank Road, University of the Punjab, Lahore, Pakistan
    Differentiation 81:42-8. 2011
    ..Therefore, it was concluded that pretreatment with injured liver tissue augment homing and hepatic differentiation abilities of MSCs and provides an improved procedure for the treatment of liver fibrosis...
  100. ncbi Hepatoprotective action of schisandrin B against carbon tetrachloride toxicity was mediated by both enhancement of mitochondrial glutathione status and induction of heat shock proteins in mice
    Man Ho Tang
    Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, China
    Biofactors 19:33-42. 2003
    ..mitochondrial glutathione status and induction of heat shock proteins (HSPs) 25/70 in protecting against carbon tetrachloride (CCl_4) hepatotoxicity in schisandrin B (Sch B)-pretreated mice...
  101. ncbi Hepatoprotective and curative properties of Kombucha tea against carbon tetrachloride-induced toxicity
    G S Murugesan
    Department of Biotechnology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India
    J Microbiol Biotechnol 19:397-402. 2009
    ..Antioxidant molecules produced during the fermentation period could be the reason for the efficient hepatoprotective and curative properties of KT against CCI4-induced hepatotoxicity...

Research Grants62

  1. Histamine modulation of biliary proliferation and damage
    Heather L Francis; Fiscal Year: 2013
    ..biliary damage (by apoptosis) induced by treatment with the hepatotoxin, carbon tetrachloride (CCl4)...
  2. Role of Platelet derived growth factor receptor-a in Liver Patho-biology
    SATDARSHAN SINGH MONGA; Fiscal Year: 2013
    ..PDGFR[unreadable] signaling in hepatic fibrosis and cirrhosis in murine models of bile duct ligation and carbon tetrachloride administration...
  3. Complement and cytokine network in liver regeneration
    John D Lambris; Fiscal Year: 2011
    ..The regenerative response is impaired after partial hepatectomy (PHx) and carbon tetrachloride (CCI4) injury in several mouse strains deficient in complement components...
  4. Involvement of Natural Killer T cells in Hepatic Fibrogenesis
    Ian N Hines; Fiscal Year: 2011
    ..Utilizing two well described models of hepatic fibrosis in rodents, carbon tetrachloride administration or bile duct ligation, and two mouse models of NKT cell deficiency, CD1d-/- mice and Ja281-/-..
  5. Role of Butyrate in the Gut-Liver Interaction of Ethanol Induced Liver Injury
    GAIL ANN CRESCI; Fiscal Year: 2013
    ..The proposed work will provide preclinical data to help determine new therapeutic management of alcoholic liver disease (ALD). ..
  6. CCR2 in Hematopoietic Stem Cell Homing, Macrophage Polarization and Organ Repair
    Israel F Charo; Fiscal Year: 2013
    ..to the resolution of inflammation and ischemic injury in models of acute (acetaminophen)- and chronic (carbon tetrachloride)-induced hepatotoxicity, will determine the fate of the recruited stem and progenitor cells, and will test ..
  7. RIP3-mediated necroptosis and ethanol-induced liver injury
    Sanjoy Roychowdhury; Fiscal Year: 2013
    ..RIP3 is also induced in mouse liver in other models of hepatic injury including carbon tetrachloride (CCl4)- and ischemia/reperfusion-induced liver damage...
  8. Genetic control of hepatic fibrogenesis
    Michael D Wheeler; Fiscal Year: 2011
    ..Collaborative Cross strains will be used to establish phenotypes associated with fibrosis induced by carbon tetrachloride. The rationale for the use of the Collaborative Cross strains is that within nearly 100 substrains over 95% ..
  9. Virtual High Throughput Screening: Specific Mechanism-based Inhibitors of CYP2E1
    Haoming Zhang; Fiscal Year: 2012
    ..of a number of hepatotoxins and procarcinogens including ethanol, acetaminophen, nitrosamines, and carbon tetrachloride, among many others. CYP2E1 is highly inducible in human livers by alcohol...
  10. Liver fibrosis and ethanol: role of the transcription factor, Egr-1
    Michele T Pritchard; Fiscal Year: 2013
    ..Indeed, recently published work completed during the K99 portion of this award revealed that carbon tetrachloride (CCI4)-induced liver fibrosis is enhanced in mice deficient in Egr-1...
  11. Trichloroethylene and Parkinson's Disease
    Samuel M Goldman; Fiscal Year: 2013
    ..The chlorinated solvents tetrachloroethylene (PERC, perchloroethylene) and carbon tetrachloride (CCl4) were also associated...
  12. Extreme Ammonia Tolerance Mechanisms: A Model Vertebrate
    Patrick Walsh; Fiscal Year: 2004
    ..In particular, liver damage due to exposure to toxicants such as carbon tetrachloride, toluene, DDT, heptachlor, etc...
  13. Sub-micrometer zero valent metal for in-situ remediation of contaminated aquifers
    JOHN FREIM; Fiscal Year: 2007
    ..will also evaluate the ability of the new powders to convert common groundwater contaminants, including carbon tetrachloride, directly to non-chlorinated compounds without producing also-toxic chlorinated intermediaries...
  14. PROTECTION FROM ENVIRONMENTAL TOXINS/MUTAGENS BY INDOLES
    HOWARD SHERTZER; Fiscal Year: 1990
    ..I-3-C), and other indole compounds protect against hepatotoxicity resulting from exposure to carbon tetrachloride (CCl4) or N-nitrosodimethylamine (NDMA)...
  15. Pathogenesis and Treatment of Alcohol-Induced Cirrhosis
    Bruce Cronstein; Fiscal Year: 2007
    ..A2A receptor-knockout mice are protected from hepatic fibrosis in two widely accepted animal models (carbon tetrachloride- and thioacetamide-induced cirrhosis) (6, 7); and secondly, mice with high circulating and tissue levels of ..
  16. LIVER SPECIFIC, INDUCIBLE TRANSGENE AND HEPATOTOXICITY
    Tsonwin Hai; Fiscal Year: 2000
    ..ATF3 is induced by physiological stressors including: a) exposure to agents such as carbon tetrachloride, acetaminophen and alcohol, b) mechanical injury, c) restriction of blood flow to the heart, and d) brain ..
  17. ANTINEOPLASTIC DRUG HEPATIC INTERACTIONS
    Dean Brenner; Fiscal Year: 1990
    ..Specific aims include the: 1) use of bromobenzene or carbon tetrachloride to produce hepatic centrilobular lesions, furosemide to produce midzonal lesions, allyl formate to produce ..
  18. METHAMPHETAMINE-POTENTIATED HEPATOTOXICITY
    Stephen Roberts; Fiscal Year: 1993
    ..that methamphetamine potentiates the liver injury from two model hepatotoxic compounds, acetaminophen and carbon tetrachloride. This potentiation caused substantial liver injury to result from doses of these compounds that otherwise ..
  19. MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTS
    Ronald Thurman; Fiscal Year: 1991
    ..The model compounds, carbon tetrachloride and allyl alcohol, selective toxins for pericentral and periportal regions of the liver, respectively, will ..
  20. BIOANALYSIS USING COATED CRYSTAL ATR/FTIR METHODS
    STERLING TOMELLINI; Fiscal Year: 1992
    ..The test analytes initially chosen will include: nitrobenzene, acetophenone, acetonitrile, toluene, carbon tetrachloride, caffeine, acetylsalicylic acid and acetaminophen...
  21. FEASIBILITY OF MODELING REACTIONS IN ENZYME ACTIVE SITES
    JAMES DIX; Fiscal Year: 1999
    ..of chloride ion with methyl chloride in water, and the reaction of hydroxide ion with 1,2-dichloroethane in carbon tetrachloride. Ab initio quantum mechanical energies will be calculated and use to parameterize a potential energy ..
  22. INNOVATIVE APPROACHES TO THE STUDY OF LIVER REGENERATION
    STEVEN RAPER; Fiscal Year: 2000
    ..the patterns of vector efficiency, gene expression and host immune response in normal, regenerating, and carbon tetrachloride-treated mouse liver using recombinant adenoviruses containing marker genes; 2) to study the expression of ..
  23. MECHANISM OF CARBON TETRACHLORIDE HEPATOTOXICITY
    Jose Castro; Fiscal Year: 1993
    ....
  24. TOXINS AND HEPATOCELLULAR PHOSPHOGLYCERIDE CATABOLISM
    ROBERT LAMB; Fiscal Year: 1990
    The hepatotoxicity of carbon tetrachloride (CCl4) is primarily a result of electrophilic metabolites such as the trichloromethyl radical (.CCl3). Yet, the mechanism(s) by which .CCl3 causes cell death are still unresolved...
  25. TOXIC LIVER INJURY: CA2+, PLA2, PROTEASES & EICONSANOIDS
    ERIC GLENDE; Fiscal Year: 1993
    ..Most of the work will be carried out with suspensions of hepatocytes exposed to carbon tetrachloride and other agents known to alter calcium homeostasis and stimulate PLA2 activity including ..
  26. IL6 IN ACUTE AND CHRONIC LIVER INJURY AND REGENERATION
    Kellen Kovalovich; Fiscal Year: 2000
    ..IL-6 reduces acute carbon tetrachloride-induced liver injury and hepatocyte apoptosis and enhances regeneration...
  27. Liver Stem Cell Response to Inflammation and Alcohol
    Ian Hines; Fiscal Year: 2005
    ..proliferation, one initiated by inflammation due to Concanavalin A (ConA) and a second by fibrosis due to carbon tetrachloride (CCI4), each followed by partial hepatectomy, we will first determine whether the type of injury affects ..
  28. CELL CALCIUM, CALCIUM PUMP, AND TOXIN ACTION
    ALBERT MOORE; Fiscal Year: 1991
    ..increase of ionized calcium in the cytoplasm produced by exposure of the cell to halogenated hydrocarbons (carbon tetrachloride, 1, 1- dichloroethylene, bromobenzene)...
  29. Microarray Discovery of Hepatic Biomarkers
    Bonnie Lau; Fiscal Year: 2009
    ..Rapid upregulation of the arginine-sensitive amino acid transporter TA1/LAT1/CD98 light chain in response to carbon tetrachloride-induced injury has been demonstrated in previous studies...
  30. THE INTERPLAY BETWEEN HEPATIC GROWTH AND METABOLISM
    Kim Olthoff; Fiscal Year: 2004
    ..to regenerate and repair and explore mechanistic defects after partial hepatectomy, acute and chronic carbon tetrachloride (CCl4) mediated liver injury and FAS mediated liver injury...
  31. INDUCTION OF P21 AND P27 IN LIVER AFTER CCL4 INJURY
    ANGELA TYNER; Fiscal Year: 2005
    DESCRIPTION: Carbon tetrachloride (CCl4) induces liver injury, which involves many pathological processes. In response to injury, the liver has the unique ability to regenerate...
  32. DNA, PROTEINS & CARBON TETRACHLORIDE HEPATOTOXICITY
    Jose Castro; Fiscal Year: 1993
    ..Results might give an insight to mechanisms of action of liver carcinogens of weak or null mutagenic nature as is CC14. ..
  33. MRP 2 (CMOAT) EXPRESSION IN HEPATOCELLULAR PROLIFERATION
    JOSE MANAUTOU; Fiscal Year: 2000
    ..proliferate following the administration of sublethal doses of two model hepatotoxicants (acetaminophen and carbon tetrachloride) have elevated expression of the canalicular ATP-dependent efflux pump for organic anions known as MRP-2, ..
  34. CLONING OF A NOVEL THERAPEUTIC HEPATOKINE
    JAMES LARRICK; Fiscal Year: 1993
    ..Highly purified hepatopoietin administered after a lethal dose of carbon tetrachloride protected the exposed mice. Serum enzymes indicate a protective effect on hepatocytes...
  35. MOLECULAR MECHANISMS OF CHEMICAL CARCINOGENESIS
    John Wong; Fiscal Year: 1980
    Our current emphasis is on radical alkylation carcinogenesis by carbon tetrachloride and the like. Our questions are: a) what reactions occur between base residues and radical species such as .CCl3 and ...
  36. REPLACEMENT OF SULFITE OXIDASE AFTER CC14 DAMAGE
    MICHAEL BRABEC; Fiscal Year: 1980
    ..The activity of this enzyme in the rat hepatic mitochondria declines during intoxication by carbon tetrachloride. The decline in activity is coincident with a disruption of the outer membrane of the mitochondrion and a ..
  37. Breast Cancer Prevention and Treatment with Noni juice
    Mian Ying Wang; Fiscal Year: 2007
    ..The latency, multiplicity, volume of tumors, and the survivor rate of animals at the end of experiment will be evaluated in different groups. ..
  38. Alcoholic Hepatitis: Molecular Mechanisms
    Stephen Safe; Fiscal Year: 2008
    ..The long-term goal of this project is to device appropriate therapies that will prevent neutrophilic steatohepatitis in chronic alcoholics by reducing neutrophil infiltration into liver. [unreadable] [unreadable] [unreadable]..
  39. Mitochondrial Dysfunction and Drug Hepatotoxicity
    HARTMUT W JAESCHKE; Fiscal Year: 2010
    ..This new insight into the signaling mechanism of AAP-induced cell death holds the promise of establishing novel therapeutic approaches for preventing AAP-induced liver failure and potentially other forms of drug toxicity in humans. ..
  40. Regulation of Hepatic Excretion of Xenobiotics by Mrps
    Curtis D Klaassen; Fiscal Year: 2010
    ..Elucidation of the role of Nrf2 in the regulation of the efflux transport process will have significant ramifications in toxicology, xenobiotics disposition, drug-drug interaction, and cancer chemoprevention. ..
  41. Oxidative Stress and Heart Failure by Copper Restriction
    Y James Kang; Fiscal Year: 2010
    ..Therefore, Cu supplementation is not an appropriate approach to rescue diabetic cardiomyopathy. ..
  42. REG OF NITRIC OXIDE PRODUCT IN THE HEPATIC CIRCULATION
    Vijay Shah; Fiscal Year: 2002
    ..Defining the mechanisms that regulate nitric oxide production in SEC may lead to therapeutic options whereby NO activity may be pharmacologically or genetically modulated and benefit patients with cirrhosis and portal hypertension. ..
  43. RELAXIN FAMILY PEPTIDES AND HEPATIC FIBROSIS
    Robert Bennett; Fiscal Year: 2009
    ..The research proposed in this application may lead to targeted therapeutic strategies for the treatment of liver disease, a major health concern in the United States. ..
  44. Molecular Mechanisms of Portal Hypertension
    Vijay Shah; Fiscal Year: 2007
    ..abstract_text> ..
  45. Survivin expression and cancer cell drug resistance
    Fengzhi Li; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  46. MECHANISTIC STUDIES ON TEA AND CARCINOGENESIS
    Chung Yang; Fiscal Year: 2005
    ..The applicant and colleagues will address key issues concerning the bioavailability and bioactivities of O-methyl, glucuronide, and sulfate derivatives and two ring-fission metabolites of tea catechins. ..
  47. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..To evaluate the kinetics and dermal bioavailability of ethylbenzene, styrene, and toluene vapor using F344 rats. ..
  48. IL-6 regulation of matrix degradation in liver fibrosis
    Meena Bansal; Fiscal Year: 2006
    ..Understanding these mechanisms will provide the basis for the development of novel anti-fibrotic therapies to treat a widely prevalent disease for which there is no effective treatment to date. ..
  49. LIVER RESPONSE TO LPS--ROLE OF LBP AND CD14
    Grace Su; Fiscal Year: 2003
    ..II. Determine the mechanism by which LBP and CD14 accelerate ingestion of Gram-negative bacteria. III. Determine the mechanisms by which LBP/CD14 mediated KC activation promote bacterial killing. ..
  50. ANTIVIRAL & ANTIFIBROTIC LIVER THERAPY OF HCV+ DRINKERS
    Charles Lieber; Fiscal Year: 2005
    ..Funds are requested for special laboratory tests, study nurses, travel to meetings, patient monitoring expenses and a core office. ..
  51. Beneficial Effects of Chemokines in Liver
    JACQUELYN MAHER; Fiscal Year: 2007
    ..If chemokines have significant cytoprotective effects, then anti-chemokine therapy may be complicated by unwanted side effects. ..
  52. Antiviral/Antifibrotic Liver Therapy of Hepatitis C positive Alcohol Drinkers
    Charles Lieber; Fiscal Year: 2007
    ..Accordingly, support is requested for the completion of this novel approach for the treatment of HCV+ patients who become abstinent or who continue to consume alcohol moderately. [unreadable] [unreadable]..
  53. Synergistic Nutraceutical Effects of DLPC and SAMe
    Charles Lieber; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  54. Endothelial Nitric Oxide Synthase & Portal Hypertension
    Vijay Shah; Fiscal Year: 2002
    ..abstract_text> ..
  55. Reactivation Methylation-Silenced Genes by Polyphenols
    Chung Yang; Fiscal Year: 2007
    ..5. To determine whether EGCG, alone or in combination with other agents, can prevent hypermethylation of genes and tumor development in the intestinal tumorigenesis model in the Min mice. ..
  56. Failure of FasL Mediated Pathways in Tumor Angiogenesis
    Vijay Shah; Fiscal Year: 2006
    ..These insights may lead to novel and effective therapeutic strategies that target this pathway to prevent angiogenesis, and thereby prevent colorectal tumor development growth and spread. ..
  57. Role of Matrix Metalloproteinase-2 in Liver Fibrosis
    Meena Bansal; Fiscal Year: 2007
    ..Findings from these investigations may lead to novel approaches to the treatment of chronic fibrosing liver disease. [unreadable] [unreadable]..
  58. Mechanisms of Neutrophil-induced Liver Toxicity
    Hartmut Jaeschke; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. BIOCHEMISTRY AND PHARMACOLOGY OF D2/E2 ISOPROSTANES
    Huiyong Yin; Fiscal Year: 2008
    ..Studies will examine mechanisms related to the formation, metabolism and biological actions of glyceryMsoPs in vivo. ..
  60. HYPOXIA AND HEPATIC FIBROGENESIS
    Victor Ankoma Sey; Fiscal Year: 2002
    ..abstract_text> ..
  61. HEPATOBILIARY DISPOSITION IN TOXICOLOGY
    Curtis Klaassen; Fiscal Year: 2003
    ..abstract_text> ..