toluene

Summary

Summary: A widely used industrial solvent.

Top Publications

  1. ncbi Phylogenetic analyses of a new group of denitrifiers capable of anaerobic growth of toluene and description of Azoarcus tolulyticus sp. nov
    J Zhou
    Department of Crop and Soil Sciences, Michigan State University, East Lansing 48824 1325, USA
    Int J Syst Bacteriol 45:500-6. 1995
  2. ncbi A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    P G Komarov
    Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Science 285:1733-7. 1999
  3. ncbi Transcriptional tradeoff between metabolic and stress-response programs in Pseudomonas putida KT2440 cells exposed to toluene
    Patricia Domínguez-Cuevas
    Department of Biochemistry and Molecular and Cellular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Profesor Albareda, 1, E 18008 Granada, Spain
    J Biol Chem 281:11981-91. 2006
  4. ncbi Electron acceptor-dependent identification of key anaerobic toluene degraders at a tar-oil-contaminated aquifer by Pyro-SIP
    Giovanni Pilloni
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    FEMS Microbiol Ecol 78:165-75. 2011
  5. ncbi Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling
    James E Dennison
    Quantitative and Computational Toxicology Group, Center for Environmental Toxicology and Technology, Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, Colorado 80523, USA
    J Occup Environ Hyg 2:127-35. 2005
  6. ncbi Biodegradation of benzene, toluene, and xylene (BTX) in liquid culture and in soil by Bacillus subtilis and Pseudomonas aeruginosa strains and a formulated bacterial consortium
    Ashis K Mukherjee
    Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784 028 Assam, India
    Environ Sci Pollut Res Int 19:3380-8. 2012
  7. ncbi A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    C Culmsee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore 21224, USA
    J Neurochem 77:220-8. 2001
  8. ncbi Genotoxicity and apoptosis in Drosophila melanogaster exposed to benzene, toluene and xylene: attenuation by quercetin and curcumin
    Mahendra P Singh
    Embryotoxicology Section, Indian Institute of Toxicology Research CSIR, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
    Toxicol Appl Pharmacol 253:14-30. 2011
  9. ncbi Assessment of the impact of the vehicular traffic on BTEX concentration in ring roads in urban areas of Bari (Italy)
    Maurizio Caselli
    Dipartimento di Chimica, Universita degli Studi di Bari, Via Orabona 4, Bari, Italy
    Chemosphere 81:306-11. 2010
  10. ncbi In situ bioremediation of monoaromatic pollutants in groundwater: a review
    Mehrdad Farhadian
    LGCB, Polytech Clermont Ferrand, Universite Blaise Pascal, Clermont Ferrand, France
    Bioresour Technol 99:5296-308. 2008

Detail Information

Publications331 found, 100 shown here

  1. ncbi Phylogenetic analyses of a new group of denitrifiers capable of anaerobic growth of toluene and description of Azoarcus tolulyticus sp. nov
    J Zhou
    Department of Crop and Soil Sciences, Michigan State University, East Lansing 48824 1325, USA
    Int J Syst Bacteriol 45:500-6. 1995
    To understand the phylogeny and taxonomy of eight new toluene-degrading denitrifying isolates, we performed a 16S rRNA sequence analysis and a gas chromatographic analysis of their cellular fatty acids and examined some of their ..
  2. ncbi A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy
    P G Komarov
    Department of Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Science 285:1733-7. 1999
    ..Thus, inhibitors of p53 may be useful drugs for reducing the side effects of cancer therapy and other types of stress associated with p53 induction...
  3. ncbi Transcriptional tradeoff between metabolic and stress-response programs in Pseudomonas putida KT2440 cells exposed to toluene
    Patricia Domínguez-Cuevas
    Department of Biochemistry and Molecular and Cellular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Profesor Albareda, 1, E 18008 Granada, Spain
    J Biol Chem 281:11981-91. 2006
    When Pseudomonas putida KT2440 cells encounter toluene in the growth medium, they perceive it simultaneously as a potential nutrient to be metabolized, as a membrane-damaging toxic drug to be extruded, and as a macromolecule-disrupting ..
  4. ncbi Electron acceptor-dependent identification of key anaerobic toluene degraders at a tar-oil-contaminated aquifer by Pyro-SIP
    Giovanni Pilloni
    Institute of Groundwater Ecology, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Neuherberg, Germany
    FEMS Microbiol Ecol 78:165-75. 2011
    ..We have previously detected a highly active fringe zone beneath a toluene plume at a tar-oil-contaminated aquifer in Germany, where a specialized community of contaminant degraders ..
  5. ncbi Evaluation of potential toxicity from co-exposure to three CNS depressants (toluene, ethylbenzene, and xylene) under resting and working conditions using PBPK modeling
    James E Dennison
    Quantitative and Computational Toxicology Group, Center for Environmental Toxicology and Technology, Department of Environmental and Radiological Health Sciences, Colorado State University, Ft Collins, Colorado 80523, USA
    J Occup Environ Hyg 2:127-35. 2005
    ..the validity of the additivity assumption, we performed unity calculations for a variety of exposures to toluene, ethylbenzene, and/or xylene using the concentration of each chemical in blood in the calculation instead of the ..
  6. ncbi Biodegradation of benzene, toluene, and xylene (BTX) in liquid culture and in soil by Bacillus subtilis and Pseudomonas aeruginosa strains and a formulated bacterial consortium
    Ashis K Mukherjee
    Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, Tezpur University, Tezpur, 784 028 Assam, India
    Environ Sci Pollut Res Int 19:3380-8. 2012
    The major aromatic constituents of petroleum products viz. benzene, toluene, and mixture of xylenes (BTX) are responsible for environmental pollution and inflict serious public concern...
  7. ncbi A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide
    C Culmsee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore 21224, USA
    J Neurochem 77:220-8. 2001
    ....
  8. ncbi Genotoxicity and apoptosis in Drosophila melanogaster exposed to benzene, toluene and xylene: attenuation by quercetin and curcumin
    Mahendra P Singh
    Embryotoxicology Section, Indian Institute of Toxicology Research CSIR, Mahatma Gandhi Marg, Lucknow 226001, Uttar Pradesh, India
    Toxicol Appl Pharmacol 253:14-30. 2011
    Monocyclic aromatic hydrocarbons (MAHs) such as benzene, toluene and xylene are being extensively used for various industrial and household purposes...
  9. ncbi Assessment of the impact of the vehicular traffic on BTEX concentration in ring roads in urban areas of Bari (Italy)
    Maurizio Caselli
    Dipartimento di Chimica, Universita degli Studi di Bari, Via Orabona 4, Bari, Italy
    Chemosphere 81:306-11. 2010
    ..The same concentration pattern and the correlation among BTEX levels in all sites confirmed the presence of a single source, the vehicular traffic, having a strong impact on air quality...
  10. ncbi In situ bioremediation of monoaromatic pollutants in groundwater: a review
    Mehrdad Farhadian
    LGCB, Polytech Clermont Ferrand, Universite Blaise Pascal, Clermont Ferrand, France
    Bioresour Technol 99:5296-308. 2008
    Monoaromatic pollutants such as benzene, toluene, ethylbenzene and mixture of xylenes are now considered as widespread contaminants of groundwater...
  11. ncbi A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures
    S Haddad
    Groupe de Recherche en Toxicologie Humaine (TOXHUM, , , Case Postale 6128, Succursale Centre-Ville, , , Canada
    Toxicol Sci 63:125-31. 2001
    ..health risk associated with occupational inhalation exposure to airborne mixtures of dichloromethane, benzene, toluene, ethylbenzene, and m-xylene...
  12. ncbi Induction of hsp70, hsp60, hsp83 and hsp26 and oxidative stress markers in benzene, toluene and xylene exposed Drosophila melanogaster: role of ROS generation
    Mahendra Pratap Singh
    Embryotoxicology Section, Indian Institute of Toxicology Research, P O Box No 80, Mahatma Gandhi Marg, Lucknow 226 001, Uttar Pradesh, India
    Toxicol Appl Pharmacol 235:226-43. 2009
    Exposure to benzene, toluene and xylene in the human population may pose a health risk. We tested a working hypothesis that these test chemicals cause cellular toxicity to a non-target organism, Drosophila melanogaster...
  13. ncbi Selective activation of p38 mitogen-activated protein kinase in dopaminergic neurons of substantia nigra leads to nuclear translocation of p53 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice
    Smitha Karunakaran
    Division of Molecular and Cellular Neurosciences, National Brain Research Centre, Nainwal Mode, Manesar 122050, India
    J Neurosci 28:12500-9. 2008
    ..Selective inhibitors of p38 may therefore, help preserve the surviving neurons in PD and slow down the disease progression...
  14. ncbi Toluene degradation by Pseudomonas putida F1. Nucleotide sequence of the todC1C2BADE genes and their expression in Escherichia coli
    G J Zylstra
    Department of Microbiology, University of Iowa, Iowa City 52242
    J Biol Chem 264:14940-6. 1989
    The nucleotide sequence of the todC1C2BADE genes which encode the first three enzymes in the catabolism of toluene by Pseudomonas putida F1 was determined...
  15. ncbi Influence of toluene co-exposure on the metabolism and genotoxicity of benzene in mice using continuous and intermittent exposures
    M G Bird
    ExxonMobil Biomedical Sciences Inc, Annandale, NJ 08801 0971, USA
    Chem Biol Interact 184:233-9. 2010
    Benzene exposure in occupational settings often occurs with concurrent exposure to toluene, the methyl-substituted derivative of benzene...
  16. ncbi A mutation in dnaK causes stabilization of the heat shock sigma factor σ32, accumulation of heat shock proteins and increase in toluene-resistance in Pseudomonas putida
    Yuka Kobayashi
    Graduate School of Life Sciences, Toyo University, Gunma, Japan
    Environ Microbiol 13:2007-17. 2011
    ..A toluene-resistant, temperature-sensitive derivative strain of Pseudomonas putida KT2442, designated KT2442-R2 (R2), ..
  17. ncbi Performances of toluene removal by activated carbon derived from durian shell
    Y J Tham
    Department of Environmental Science, Faculty of Environmental Studies, Universiti Putra Malaysia, 43400, UPM Serdang, Selangor, Malaysia
    Bioresour Technol 102:724-8. 2011
    ..prompted this research in assessing the effectiveness of activated carbon produced from durian shell in removing toluene vapors...
  18. ncbi Street and working children of Delhi, India, misusing toluene: an ethnographic exploration
    Rajeev Seth
    VIMHANS and PCI, New Delhi, India
    Subst Use Misuse 40:1659-79. 2005
    ..A purposive sample of those working children who were using toluene was selected by Snowball sampling...
  19. ncbi p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism
    Andrew J Steele
    Department of Hematology, Royal Free and University College Medical School, London, United Kingdom
    Blood 112:3827-34. 2008
    ..Therefore, strategies that block up-regulation of p53-mediated transcription may be of value in enhancing apoptosis induction of CLL cells by p53-elevating drugs...
  20. ncbi Evaluation of genotoxicity and oxidative damage in painters exposed to low levels of toluene
    Angela M Moro
    Department of Clinical and Toxicology Analysis, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Mutat Res 746:42-8. 2012
    b>Toluene is an organic solvent used in numerous processes and products, including industrial paints...
  21. ncbi Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure
    Y L Lee
    Department of Environmental and Occupational Health, National Cheng Kung University Medicine College, Tainan, Taiwan
    Occup Med (Lond) 53:479-82. 2003
    ..We report a 38-year-old male worker with chronic toluene exposure who developed symptoms such as palpitation, insomnia, dizziness with headache, memory impairment, ..
  22. ncbi Toluene depletion in produced oil contributes to souring control in a field subjected to nitrate injection
    Akhil Agrawal
    Petroleum Microbiology Research Group, Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada
    Environ Sci Technol 46:1285-92. 2012
    ..Interestingly, oil produced by 2-PW was depleted of toluene, the preferred electron donor for nitrate reduction...
  23. ncbi Atmospheric BTX and polyaromatic hydrocarbons in Rio de Janeiro, Brazil
    Milena B Fernandes
    Laboratorio de Toxicologia, CESTEH ENSP, Fundacao Oswaldo Cruz, Rio de Janeiro, RJ, Brazil
    Chemosphere 47:417-25. 2002
    Polycyclic aromatic and monoaromatic (benzene, toluene and xylene, or BTX) hydrocarbons were monitored in Rio de Janeiro, Brazil, during the summer of 1998/1999...
  24. ncbi Co-metabolic conversion of toluene in anaerobic n-alkane-degrading bacteria
    Ralf Rabus
    Universitat Oldenburg, Carl von Ossietzky Straße 9 11, 26111 Oldenburg, Germany
    Environ Microbiol 13:2576-86. 2011
    ..alkylbenzene degraders (five denitrifying, three sulfate-reducing) were incubated with mixtures of n-alkanes and toluene. Whereas the toluene degradationers formed only the characteristic toluene-derived benzylsuccinate and benzoate, ..
  25. ncbi Inhibition of gap junction currents by the abused solvent toluene
    Angelo M Del Re
    Department of Physiology and Neuroscience, Center for Drug and Alcohol Programs, 173 Ashley Avenue, P O Box 250510, Medical University of South Carolina, Charleston, SC 29425, USA
    Drug Alcohol Depend 78:221-4. 2005
    ..include chemicals with known therapeutic uses such as anesthetic gases as well as volatile organic solvents like toluene that are found in paint thinners and adhesives...
  26. ncbi Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats
    Peitan Liu
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, 2 Medical Center Drive, Stratford, NJ 08084, U S A
    Shock 26:608-14. 2006
    ..The mechanism of protective effect of PFT may involve the inhibition of p53 transcriptional function, thereby attenuating the p53/Bax-mediated myocyte apoptosis during the reperfusion period...
  27. pmc Medial prefrontal cortex inversely regulates toluene-induced changes in markers of synaptic plasticity of mesolimbic dopamine neurons
    Jacob T Beckley
    Department of Neurosciences, and Center for Drug and Alcohol Programs, Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Neurosci 33:804-13. 2013
    b>Toluene is a volatile solvent that is intentionally inhaled by children, adolescents, and adults for its intoxicating effects...
  28. ncbi Comparative assessments of benzene, toluene, and xylene natural attenuation by quantitative polymerase chain reaction analysis of a catabolic gene, signature metabolites, and compound-specific isotope analysis
    Harry R Beller
    Lawrence Livermore National Laboratory, Livermore, California, USA
    Environ Sci Technol 42:6065-72. 2008
    ..conducted at Vandenberg Air Force Base involved the injection of anaerobic groundwater amended with benzene, toluene, and o-xylene (BToX; 1-3 mg/L each) in two parallel lanes: lane A injectate contained no ethanol, whereas lane B ..
  29. ncbi Role of CD4(+) T cells in the modulation of neurotrophin production in mice exposed to low-level toluene
    Hidekazu Fujimaki
    National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan
    Immunopharmacol Immunotoxicol 31:146-9. 2009
    To investigate the role of CD4(+) T cells in neurotrophin production following toluene exposure, male C3H mice were exposed to filtered air (control) or 9 ppm of toluene in a nose-only exposure chamber for 30 min on 3 consecutive days ..
  30. ncbi Single-voxel proton MR spectroscopy in toluene abuse
    Kubilay Aydin
    Department of Radiology, Neuroradiology Division, Istanbul University, Istanbul Medical School, Capa Istanbul, Turkey
    Magn Reson Imaging 21:777-85. 2003
    Inhalation of toluene, which is an organic solvent, causes toxic encephalopathy characterized by cognitive impairment, cerebellar and extra-pyramidal symptoms...
  31. pmc Depth-resolved quantification of anaerobic toluene degraders and aquifer microbial community patterns in distinct redox zones of a tar oil contaminant plume
    Christian Winderl
    Institute of Groundwater Ecology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany
    Appl Environ Microbiol 74:792-801. 2008
    ..community distribution across a high-resolution depth profile of a tar oil-impacted aquifer where benzene, toluene, ethylbenzene, and xylene (BTEX) degradation depends mainly on sulfate reduction...
  32. pmc Site-specific recombination system encoded by toluene catabolic transposon Tn4651
    Hiroyuki Genka
    Department of Environmental Life Sciences, Graduate School of Life Sciences, Tohoku University, 2 1 1 Katahira, Sendai 980 8577, Japan
    J Bacteriol 184:4757-66. 2002
    The 56-kb class II toluene catabolic transposon Tn4651 from Pseudomonas putida plasmid pWW0 is unique in that (i) its efficient resolution requires, in addition to the 0...
  33. pmc A set of genes encoding a second toluene efflux system in Pseudomonas putida DOT-T1E is linked to the tod genes for toluene metabolism
    G Mosqueda
    Department of Biochemistry and Molecular Biology of Plants, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18008 Granada, Spain
    J Bacteriol 182:937-43. 2000
    Sequence analysis in Pseudomonas putida DOT-T1E revealed a second toluene efflux system for toluene metabolism encoded by the ttgDEF genes, which are adjacent to the tod genes...
  34. ncbi Significant enhancement of (R)-mandelic acid production by relieving substrate inhibition of recombinant nitrilase in toluene-water biphasic system
    Zhi Jun Zhang
    Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    J Biotechnol 152:24-9. 2011
    ..b>Toluene was found to be the most suitable solvent as the organic phase among the solvents tested...
  35. ncbi Development of a versatile, easy and rapid atmospheric monitor for benzene, toluene, ethylbenzene and xylenes determination in air
    Francesc A Esteve-Turrillas
    Analytical Chemistry Department, University of Valencia, Edifici Jeroni Muñoz, 50 Dr Moliner, 46100 Burjassot, Valencia, Spain
    J Chromatogr A 1216:8549-56. 2009
    A new procedure for the passive sampling in air of benzene, toluene, ethylbenzene and xylene isomers (BTEX) is proposed...
  36. ncbi Colour vision and occupational toluene exposure: results of repeated examinations
    Michael Schäper
    Institut fur Arbeitsphysiologie an der Universitat Dortmund, Ardeystr 67, D 44139 Dortmund, Germany
    Toxicol Lett 151:193-202. 2004
    Potential effects of human occupational exposures to toluene on colour vision were investigated in a follow-up study over 4 years with three repeated examinations...
  37. ncbi Biochemical and genetic characterization of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism
    B Leuthner
    Mikrobiologie, , , Germany
    Mol Microbiol 28:615-28. 1998
    b>Toluene is anoxically degraded to CO2 by the denitrifying bacterium Thauera aromatica. The initial reaction in this pathway is the addition of fumarate to the methyl group of toluene, yielding benzylsuccinate as the first intermediate...
  38. pmc Effects of iron limitation on the degradation of toluene by Pseudomonas strains carrying the tol (pWWO) plasmid
    I J Dinkla
    Department of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, 9747 AG Groningen, The Netherlands
    Appl Environ Microbiol 67:3406-12. 2001
    ..We investigated the effects of iron limitation on the degradation of toluene by Pseudomonas putida mt2 and the transconjugant rhizosphere bacterium P...
  39. pmc Proteomic analysis reveals the participation of energy- and stress-related proteins in the response of Pseudomonas putida DOT-T1E to toluene
    Ana Segura
    EEZ CSIC, C Prof Albareda, 1, E 18008 Granada, Spain
    J Bacteriol 187:5937-45. 2005
    Pseudomonas putida DOT-T1E is tolerant to toluene and other toxic hydrocarbons through extrusion of the toxic compounds from the cell by means of three efflux pumps, TtgABC, TtgDEF, and TtgGHI...
  40. ncbi Characterization of skin inflammation induced by repeated exposure of toluene, xylene, and formaldehyde in mice
    Asaka Saito
    Laboratory of Pharmacology, Department of Bioactive Molecules, Gifu Pharmaceutical University, Gifu, Japan
    Environ Toxicol 26:224-32. 2011
    ..Various concentrations of toluene, xylene, and formaldehyde (FA) were applied once a week for 5 weeks...
  41. ncbi Validity of new biomarkers of internal dose for use in the biological monitoring of occupational and environmental exposure to low concentrations of benzene and toluene
    Piero Lovreglio
    Dipartimento di Medicina Interna e Medicina Pubblica, Sezione di Medicina del Lavoro E C Vigliani, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Int Arch Occup Environ Health 83:341-56. 2010
    ..more sensitive and specific urinary biomarkers of internal dose, namely, urinary benzene for benzene and urinary toluene and S-benzylmercapturic acid (SBMA) for toluene, to assess their efficacy when compared to traditional biomarkers ..
  42. ncbi Effects of inorganic nutrient levels on the biodegradation of benzene, toluene, and xylene (BTX) by Pseudomonas spp. in a laboratory porous media sand aquifer model
    Jiin Shuh Jean
    Department of Earth Sciences, National Cheng Kung University, Tainan City 70101, Taiwan
    Bioresour Technol 99:7807-15. 2008
    ..of inorganic nutrients (sulfate, phosphate, and ammonium chloride) on the aerobic biodegradation of benzene, toluene, and xylene (BTX) by Pseudomonas spp. was studied in the laboratory using a glass sand tank...
  43. ncbi Toluene inhibits hippocampal neurogenesis in adult mice
    Heung Sik Seo
    Department of Veterinary Anatomy, College of Veterinary Medicine and Animal Medical Institute, Chonnam National University, Gwangju 500 757, South Korea
    Pharmacol Biochem Behav 94:588-94. 2010
    b>Toluene, a representative industrial solvent and abused inhalant, decreases neuronal activity in vitro and causes mental depression and cognitive impairment in humans...
  44. ncbi Reproductive toxicology and teratology of abused toluene
    John H Hannigan
    Merrill Palmer Skillman Institute, Department of Obstetrics and Gynecology, C S Mott Center for Human Growth and Development, Wayne State University, Detroit, MI 48202, USA
    Syst Biol Reprod Med 56:184-200. 2010
    b>Toluene is an organic solvent that is widely used by industry and is ubiquitous in our environment. As a result, exposure to solvents like toluene in work-related settings (i.e...
  45. ncbi Nigella sativa and derived thymoquinone prevents hippocampal neurodegeneration after chronic toluene exposure in rats
    Mehmet Kanter
    Department of Histology and Embryology, Faculty of Medicine, Trakya University, Edirne, Turkey
    Neurochem Res 33:579-88. 2008
    ..effects of Nigella sativa (NS) and derived thymoquinone (TQ) on neurodegeneration in hippocampus after chronic toluene exposure in rats...
  46. ncbi Volatile organic compounds (VOCs) in urban atmosphere of Hong Kong
    S C Lee
    Department of Civil and Structural Engineering, Research Center for Urban Environmental Technology and Management, The Hong Kong Polytechnic University, Hung Hom, Kowloon
    Chemosphere 48:375-82. 2002
    ..The concentrations of VOCs ranged from undetectable to 1396 microg/m3. Among all of the VOC species, toluene has the highest concentration...
  47. ncbi Detection of anaerobic toluene and hydrocarbon degraders in contaminated aquifers using benzylsuccinate synthase (bssA) genes as a functional marker
    Christian Winderl
    Institute of Groundwater Ecology, GSF National Research Center for Environment and Health, Neuherberg, Germany
    Environ Microbiol 9:1035-46. 2007
    Benzylsuccinate synthase (Bss) is the key enzyme of anaerobic toluene degradation and has been found in all anaerobic toluene degrading bacterial isolates tested...
  48. ncbi Chemostat-based proteomic analysis of toluene-affected Pseudomonas putida S12
    Rita J M Volkers
    TNO Quality of Life, Laan van Westenenk 501, 7334 DT Apeldoorn, The Netherlands
    Environ Microbiol 8:1674-9. 2006
    The aim of this study was to assess the cellular response of the solvent-tolerant Pseudomonas putida S12 to toluene as the single effector...
  49. ncbi Rapid conversion of toluene by an acinetobacter sp. Tol 5 mutant showing monolayer adsorption to water-oil interface
    Hisami Watanabe
    Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    J Biosci Bioeng 106:226-30. 2008
    ..We achieved a toluene conversion rate 10-fold faster than any experimental data previously demonstrated, using a novel bacterium in a ..
  50. ncbi Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis
    Giyasettin Baydas
    Department of Physiology, College of Medicine, Firat University, Elazig 23110, Turkey
    Toxicol Lett 137:169-74. 2003
    ..Thinner containing 60-70% toluene is a neurotoxic mixture which is widely used as an aromatic industrial solvent...
  51. ncbi Air quality assessment in Southern Kuwait using diffusive passive samplers
    A A Ramadan
    Coastal and Air Pollution Department, Kuwait Institute for Scientific Research, P O Box 24885, 13109, Safat, Kuwait
    Environ Monit Assess 160:413-23. 2010
    ..average concentrations of NO, NO2, SO2, H2S, NH3, and volatile organic compounds (VOCs) (aromatics=benzene, toluene, o-xylene, m+p-xylene, ethyl benzene; non-aromatics=nonane and octane) were carried out in the period from 26/10/..
  52. ncbi Hypothalamo-pituitary-adrenal gland axis in mice inhaling toluene prior to low-level long-term exposure to formaldehyde
    Dwi Kesuma Sari
    Laboratory of Veterinary Anatomy, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, Sakai, Osaka 599 8531, Japan
    J Vet Med Sci 67:303-9. 2005
    We studied the change in the hypothalamo-pituitary-adrenal gland (HPA) axis upon adding prior toluene inhalation to our previous formaldehyde inhalation experiments to determine whether short term exposure to relatively high levels of ..
  53. ncbi Were volatile organic compounds the inducing factors for subjective symptoms of employees working in newly constructed hospitals?
    Tomoko Takigawa
    Department of Public Health, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Environ Toxicol 19:280-90. 2004
    ....
  54. ncbi Methanogenic toluene metabolism: community structure and intermediates
    S Jane Fowler
    Petroleum Microbiology Research Group, Department of Biological Sciences, University of Calgary, Calgary, AB, Canada T2N 1N4
    Environ Microbiol 14:754-64. 2012
    b>Toluene is a model compound used to study the anaerobic biotransformation of aromatic hydrocarbons...
  55. ncbi A field method for sampling toluene in end-exhaled air, as a biomarker of occupational exposure: correlation with other exposure indices
    Sergio Ghittori
    Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS Istituto Scientifico di Pavia, Via Ferrata 8, 27100 Pavia, Italy
    Ind Health 42:226-34. 2004
    A sensitive and rapid method for the determination of toluene in exhaled air is described...
  56. ncbi Involvement of NO/cGMP pathway in toluene-induced locomotor hyperactivity in female rats
    Ming Huan Chan
    Institute of Pharmacology and Toxicology, Tzu Chi University, 701, Section 3, Chung Yang Road, Hualien, Taiwan, ROC
    Psychopharmacology (Berl) 176:435-9. 2004
    Nitric oxide (NO) is implicated in the acute locomotor activating effects of some addictive drugs such as amphetamine, caffeine, and PCP, but has not been investigated in the case of toluene.
  57. pmc Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma
    Tobias Engel
    Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, 123 St Stephen s Green, Dublin 2, Ireland
    FASEB J 24:853-61. 2010
    ..Engel, T., Murphy, B. M., Hatazaki, S., Jimenez-Mateos, E. M., Concannon, C. G., Woods, I., Prehn, J. H. M., Henshall, D. C. Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapoptotic Puma...
  58. ncbi Determination of benzene, toluene, ethylbenzene and xylenes in soils by multiple headspace solid-phase microextraction
    Oscar Ezquerro
    Department of Chemistry, University of La Rioja, C Madre de Dios 51, 26006 Logrono, La Rioja, Spain
    J Chromatogr A 1035:17-22. 2004
    ..In this paper, the quantitative determination of benzene, toluene, ethylbenzene and xylene isomers (BTEX) in a certified soil (RTC-CRM304, LGC Promochem) and in a contaminated ..
  59. ncbi CYP2E1 phenotype in Mexican workers occupationally exposed to low levels of toluene
    Octavio Jiménez-Garza
    Health Sciences Division, Universidad de Guanajuato Campus León, Leon, Guanajuato, Mexico
    Toxicol Lett 210:254-63. 2012
    ..One indirect way to monitor exposure to VOCs may be, therefore, the assessment of CYP2E1 activity in vivo using the chlorzoxazone (CHZ) test...
  60. ncbi Fungal/bacterial interactions during the biodegradation of TEX hydrocarbons (toluene, ethylbenzene and p-xylene) in gas biofilters operated under xerophilic conditions
    Francesc X Prenafeta-Boldú
    Laboratory of Applied and Environmental Microbiology, IRTA GIRO, Torre Marimon, Caldes de Montbui, Barcelona, Catalonia, Spain
    FEMS Microbiol Ecol 80:722-34. 2012
    The treatment of air contaminated with toluene, ethylbenzene, and p-xylene was assayed in three laboratory-scale biofilters, each consisting of two modules connected in series, packed with a pelletized organic fertilizer and inoculated ..
  61. ncbi Chronic toluene misuse among Roma youth in Eastern Slovakia
    Peter Važan
    National Development and Research Institutes, New York, USA
    Subst Use Misuse 46:57-61. 2011
    This report presents pilot data on toluene misuse among Roma (Gypsy) youth in eastern Slovakia...
  62. ncbi Repeated toluene exposure modifies the acetylation pattern of histones H3 and H4 in the rat brain
    S L Sánchez-Serrano
    Departamento de Farmacobiologia, Centro de Investigación y de Estudios Avanzados Cinvestav, Calzada de los Tenorios 235, Col Granjas Coapa, CP 14330, Mexico D F, Mexico
    Neurosci Lett 489:142-7. 2011
    b>Toluene is a volatile organic solvent with addictive potential that exhibits similarities in its physiological effects and modes of action to other addictive drugs...
  63. ncbi Effects of maternal toluene exposure on testosterone levels in fetal rats
    Shinji Tsukahara
    Research Center for Environmental Risk, National Institute for Environmental Studies, Onogawa 16 2, Tsukuba, Ibaraki 305 8506, Japan
    Toxicol Lett 185:79-84. 2009
    The goal of our study was to determine if toluene affected the synthesis and secretion of testosterone in fetal rats. Dams were exposed to atmospheres that contained 0.09 ppm, 0...
  64. pmc Simultaneous catabolite repression between glucose and toluene metabolism in Pseudomonas putida is channeled through different signaling pathways
    Teresa del Castillo
    EEZ CSIC, C Prof Albareda, 1, E 18008 Granada, Spain
    J Bacteriol 189:6602-10. 2007
    Pseudomonas putida KT2440(pWW0) can use toluene via the TOL plasmid-encoded catabolic pathways and can use glucose via a series of three peripheral chromosome-encoded routes that convert glucose into 6-phosphogluconate (6PG), namely, the ..
  65. ncbi Effects of adsorptive properties of biofilter packing materials on toluene removal
    Dong Ik Oh
    Korea Environmental Industry and Technology Institute, Seoul, Republic of Korea
    J Hazard Mater 170:144-50. 2009
    ..carbon (GAC) and ground tire rubber (GTR), were mixed with compost in biofilters used for treating gaseous toluene, and the effects of the mixtures on the stability of biofilter performance were investigated...
  66. ncbi Control of optically active structure of thioether-phthalocyanine aggregates by chiral Pd(II)-BINAP complexes in toluene and at the toluene/water interface
    Kenta Adachi
    Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka, Japan
    Chirality 18:599-608. 2006
    ..phthalocyanatomagnesium(II) compounds (MgPc(SR)8, SR is benzylthio (SBz) or benzhydrylthio (Bh)) was formed in toluene and at the toluene/water interface, and investigated by means of UV-Vis absorption and circular dichroism (CD) ..
  67. ncbi Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53
    D Sohn
    Laboratory of Molecular Radiooncology, Clinic and Policlinic for Radiation Therapy and Radiooncology, University of Dusseldorf, Dusseldorf, Germany
    Cell Death Differ 16:869-78. 2009
    ..Thus, our data show that PFT-alpha protects cells from DNA damage-induced apoptosis also by a p53-independent mechanism that takes place downstream of mitochondria and that might involve cyclin D1...
  68. ncbi Multiple actions of pifithrin-alpha on doxorubicin-induced apoptosis in rat myoblastic H9c2 cells
    Chu Chang Chua
    Cardiovascular Research Laboratory, James H Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614, USA
    Am J Physiol Heart Circ Physiol 290:H2606-13. 2006
    ..Our results suggest that p53 stabilization is a focal point of Dox-induced apoptosis and that PFT-alpha interferes with multiple steps of Dox-induced apoptosis...
  69. ncbi Removal of toluene vapour using agro-waste as biofilter media
    R S Singh
    Department of Chemical Engineering and Technology, Centre of Advanced Study, Institute of Technology, Banaras Hindu University, Varanasi, India
    Bioresour Technol 97:2296-301. 2006
    Biodegradation of toluene vapour was investigated in a laboratory scale biofilter packed with cylindrical pieces of yellow-gram (Cajanus cajan) stalk. Inlet concentrations and volumetric flow rates of toluene were varied from 2.56 to 34...
  70. ncbi DNA-SIP identifies sulfate-reducing Clostridia as important toluene degraders in tar-oil-contaminated aquifer sediment
    Christian Winderl
    Institute of Groundwater Ecology, Helmholtz Zentrum München German Research Centre for Environmental Health, Neuherberg, Germany
    ISME J 4:1314-25. 2010
    ..Here, by DNA-based stable isotope probing (SIP), we directly identified the most active sulfate-reducing toluene degraders in a diverse sedimentary microbial community originating from a tar-oil-contaminated aquifer at a ..
  71. ncbi Effect of D-cycloserine on spatial learning performance and memory function-related gene expression in mice following toluene exposure
    Tin Tin Win-Shwe
    Research Center for Environmental Risk, National Institute for Environmental Studies, 16 2 Onogawa, Tsukuba, Ibaraki 305 8506, Japan
    J UOEH 32:127-40. 2010
    ..To investigate the effect of DCS in cognitive function following toluene exposure, eight-week-old male C3H/HeN mice were exposed to filtered air (0 ppm) or 50 ppm toluene for 6 h a day ..
  72. ncbi Indoor and outdoor air concentrations of BTEX and determinants in a cohort of one-year old children in Valencia, Spain
    Ana Esplugues
    Spanish Consortium for Research on Epidemiology and Public Health CIBERESP, Parc de Recerca Biomedica de Barcelona, Doctor Aiguader, 88 1ª Planta, 8003 Barcelona, Spain
    Sci Total Environ 409:63-9. 2010
    BTEX is the commonly used term for a group of toxic compounds (benzene, toluene, ethyl benzene, ortho-xylene and meta- and para-xylene), some of which, most notably benzene, are known carcinogens...
  73. pmc Production of 6-phenylacetylene picolinic acid from diphenylacetylene by a toluene-degrading Acinetobacter strain
    Jim C Spain
    Air Force Research Laboratory MLQL, 139 Barnes Drive, Ste 2, Tyndall Air Force Base, FL 32403 6090, USA
    Appl Environ Microbiol 69:4037-42. 2003
    ..We screened 139 toluene-degrading strains that use a variety of catabolic pathways for the ability to catalyze oxidative transformation ..
  74. pmc Outer membrane changes in a toluene-sensitive mutant of toluene-tolerant Pseudomonas putida IH-2000
    H Kobayashi
    Deep Sea Microorganisms Research Group, Japan Marine Science and Technology Center, Yokosuka 237 0061, Japan
    J Bacteriol 181:4493-8. 1999
    We isolated a toluene-sensitive mutant, named mutant No. 32, which showed unchanged antibiotic resistance levels, from toluene-tolerant Pseudomonas putida IH-2000 by transposon mutagenesis with Tn5...
  75. ncbi Combined participation of hydroxylase active site residues and effector protein binding in a para to ortho modulation of toluene 4-monooxygenase regiospecificity
    Kevin H Mitchell
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Biochemistry 41:3176-88. 2002
    b>Toluene 4-monooxygenase (T4MO) is a diiron hydroxylase that exhibits high regiospecificity for para hydroxylation...
  76. ncbi Toluene-induced hearing loss: a mid-frequency location of the cochlear lesions
    P Campo
    Institut National de Recherche et de Sécurité I N R S, Vandoeuvre, France
    Neurotoxicol Teratol 19:129-40. 1997
    Inhaled toluene (from 1000 to 2000 ppm, 6 h/day, 5 days/week, 4 weeks) is anototoxic solvent that severely damaged the cochlea in adult Long-Evans rats...
  77. ncbi Phospholipid compositional changes of five pseudomonad archetypes grown with and without toluene
    J Fang
    Department of Civil and Environmental Engineering, The University of Michigan, Ann Arbor 48109 2099, USA
    Appl Microbiol Biotechnol 54:382-9. 2000
    Bacterial physiological responses to toluene exposure were investigated in five reference pseudomonad strains that express different toluene degradation pathways: Pseudomonas putida mt-2, Pseudomonas putida F1, Burkholderia cepacia G4, ..
  78. ncbi Bacterial community structure and bamA gene diversity in anaerobic degradation of toluene and benzoate under denitrifying conditions
    Y N Li
    School of Environmental Science and Technology, Tianjin University, Nankai District, Tianjin, China
    J Appl Microbiol 112:269-79. 2012
    To characterize the microbial community structure and bamA gene diversity involved in anaerobic degradation of toluene and benzoate under denitrifying conditions.
  79. pmc The abused inhalant toluene differentially modulates excitatory and inhibitory synaptic transmission in deep-layer neurons of the medial prefrontal cortex
    Jacob T Beckley
    Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29425, USA
    Neuropsychopharmacology 36:1531-42. 2011
    Volatile organic solvents such as toluene are voluntarily inhaled for their intoxicating effects...
  80. ncbi Breakthrough of toluene vapours in granular activated carbon filled packed bed reactor
    N Mohan
    Defence Bio Engineering and Electro Medical Laboratory, Defence R and D Organisation, CVRaman Nagar, Bangalore, India
    J Hazard Mater 168:777-81. 2009
    The objective of this research was to determine the toluene removal efficiency and breakthrough time using commercially available coconut shell-based granular activated carbon in packed bed reactor...
  81. ncbi Remarkable aliphatic hydroxylation by the diiron enzyme toluene 4-monooxygenase in reactions with radical or cation diagnostic probes norcarane, 1,1-dimethylcyclopropane, and 1,1-diethylcyclopropane
    Luke A Moe
    Department of Biochemistry, College of Agricultural and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Biochemistry 43:15688-701. 2004
    b>Toluene 4-monooxygenase (T4MO) catalyzes the hydroxylation of toluene to yield 96% p-cresol. This diiron enzyme complex was used to oxidize norcarane (bicyclo[4.1...
  82. ncbi Effects of inhalation exposure to a binary mixture of benzene and toluene on vitamin a status and humoral and cell-mediated immunity in wild and captive American kestrels
    Mandy L Olsgard
    Toxicology Centre, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Toxicol Environ Health A 71:1100-8. 2008
    Benzene and toluene are representative volatile organic compounds (VOC) released during production, storage, and transportation associated with the oil and gas industry and are chemicals of concern, as they are released in greater and ..
  83. ncbi Catalytic activity of lignin peroxidase and partition of veratryl alcohol in AOT/isooctane/toluene/water reverse micelles
    Wenjuan Zhang
    Key Lab for Colloid and Interface Chemistry of the Education Ministry of China, Shandong University, Jinan, 250100, People s Republic of China
    Appl Microbiol Biotechnol 70:315-20. 2006
    ..of its optimum substrate veratryl alcohol (VA) in sodium bis(2-ethylhexyl)sulfosuccinate (AOT)/isooctane/toluene/water reverse micelles were studied in this paper to understand the microheterogeneous effect of the medium on ..
  84. pmc Neurochemical changes after acute binge toluene inhalation in adolescent and adult rats: a high-resolution magnetic resonance spectroscopy study
    Shonagh K O'Leary-Moore
    Department of Psychology, Wayne State University, Detroit, MI 48201, USA
    Neurotoxicol Teratol 31:382-9. 2009
    Inhalant abuse in young people is a growing public health concern. We reported previously that acute toluene intoxication in young rats, using a pattern of exposures that approximate abuse patterns of inhalant use in humans, ..
  85. ncbi Toluene monooxygenase from the fungus Cladosporium sphaerospermum
    Dion M A M Luykx
    Division of Industrial Microbiology, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Biochem Biophys Res Commun 312:373-9. 2003
    Assimilation of toluene by Cladosporium sphaerospermum is initially catalyzed by toluene monooxygenase (TOMO). TOMO activity was induced by adding toluene to a glucose-pregrown culture of C. sphaerospermum...
  86. ncbi Phylogenetic and proteomic analysis of an anaerobic toluene-degrading community
    N Jehmlich
    Helmholtz Centre for Environmental Research UFZ, Department of Proteomics, Leipzig, Germany
    J Appl Microbiol 109:1937-45. 2010
    This study intended to unravel the physiological interplay in an anaerobic microbial community that degrades toluene under sulfate-reducing conditions combining proteomic and genetic techniques.
  87. ncbi Review of the epidemiological evidence relating toluene to reproductive outcomes
    J A Bukowski
    Occupational and Public Health Division, ExxonMobil Biomedical Sciences, Inc, 1545 Route 22 East, Annandale, NJ 08801-0971, USA
    Regul Toxicol Pharmacol 33:147-56. 2001
    ..the epidemiological evidence for adverse reproductive outcomes from those occupational studies that present toluene-specific findings. Clinical investigations of the reproductive effects of toluene abuse are also examined...
  88. ncbi The effects of toluene on the central nervous system
    Christopher M Filley
    Department of Neurology, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    J Neuropathol Exp Neurol 63:1-12. 2004
    In recent decades the organic solvent toluene (methylbenzene) has emerged as one of the best-studied neurotoxins...
  89. pmc A nanopore structured high performance toluene gas sensor made by nanoimprinting method
    Kwang Su Kim
    Department of Nano Science and Engineering, Myongji University, Gyeonggi 449 728, Korea
    Sensors (Basel) 10:765-74. 2010
    b>Toluene gas was successfully measured at room temperature using a device microfabricated by a nanoimprinting method...
  90. ncbi Analytical characteristics of the determination of benzene, toluene, ethylbenzene and xylenes in water by headspace solvent microextraction
    Andrzej Przyjazny
    Kettering University, Science and Mathematics Department, 1700 West Third Avenue, Flint, MI 48504, USA
    J Chromatogr A 977:143-53. 2002
    ..This paper presents analytical characteristics of HSM as applied to the determination of benzene, toluene, ethylbenzene and xylenes in water.
  91. ncbi Cranial MR findings in chronic toluene abuse by inhalation
    Kubilay Aydin
    Department of Radiology, Istanbul University Medical School, Capa Hospital, Turkey
    AJNR Am J Neuroradiol 23:1173-9. 2002
    Chronic abuse of toluene by inhalation causes variable white matter changes and thalamic hypointensity on T2-weighted MR images...
  92. ncbi Use of biological activated carbon to treat mixed gas of toluene and benzene in biofilter
    G W Li
    ESPC, Department of Environment Science and Engineering, Tsinghua University, Beijing, China
    Environ Technol 23:467-77. 2002
    The biodegradation of toluene and benzene in a biofilter filled with cylindrical activated carbon was studied. Three various gaseous flow rates, i.e. 0.25, 0.50 and 0.75 m3 h(-1), corresponding to empty bed gas residences of 75, 37...
  93. ncbi Headspace microdrop analysis--an alternative test method for gasoline diluent and benzene, toluene, ethylbenzene and xylenes in used engine oils
    John M Kokosa
    Science and Mathematics Department, Kettering University, 1700 West Third Avenue, Flint, MI 48504 4898, USA
    J Chromatogr A 983:205-14. 2003
    ..analysis yields results comparable to those obtained using the ASTM method, with the added benefit that it allows the quantification of individual volatile diluent components, including benzene, toluene, ethylbenzene and the xylenes.
  94. ncbi Assessment through environmental and biological measurements of total daily exposure to volatile organic compounds of office workers in Milan, Italy
    P Carrer
    Department of Occupational Health, Istituti Clinici di Perfezionamento, Milan, Italy
    Indoor Air 10:258-68. 2000
    Personal exposure to total volatile organic compounds (TVOCs), benzene and toluene of 100 Milan office workers was assessed through personal air monitoring at home, in the office, and during commuting...
  95. ncbi Bacterial aerobic degradation of benzene, toluene, ethylbenzene and xylene
    E Jindrova
    Institute of Microbiology, Academy of Sciences of the Czech Republic, Institute of Chemical Technology, Prague, Czechia
    Folia Microbiol (Praha) 47:83-93. 2002
    Several aerobic metabolic pathways for the degradation of benzene, toluene, ethylbenzene and xylene (BTEX), which are provided by two enzymic systems (dioxygenases and monooxygenases), have been identified...
  96. ncbi Distribution of c-Fos immunoreactivity in the rat brain following abuse-like toluene vapor inhalation
    Kristina E Perit
    Department of Psychology, Wilfrid Laurier University, Waterloo, Ontario, Canada, N2L 3C5
    Neurotoxicol Teratol 34:37-46. 2012
    Inhalation of vapors from toluene-containing products results in euphoria accompanied by a variety of cognitive impairments and motor dysfunctions...
  97. ncbi Addressing biofilter limitations: a two-phase partitioning bioreactor process for the treatment of benzene and toluene contaminated gas streams
    Colin T Davidson
    Department of Chemical Engineering, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Biodegradation 14:415-21. 2003
    ..partitioning bioreactor (TPPB) achieved simultaneous and continuous removal and degradation of benzene and toluene from an air stream...
  98. ncbi Determination of volatile organic compounds in biological samples using headspace solid-phase microextraction and gas chromatography: toluene and styrene
    Radhika Barua
    Department of Clinical and Laboratory Sciences, SUNY at Buffalo, Buffalo, New York, USA
    J Anal Toxicol 32:379-86. 2008
    Epidemiological and laboratory investigations have shown that toluene and styrene are toxic compounds that lead to impairment of the nervous system...
  99. ncbi Effects of abuse pattern of gestational toluene exposure on metabolism, feeding and body composition
    Patricia A Jarosz
    College of Nursing, Wayne State University, Detroit, MI 48202, USA
    Physiol Behav 93:984-93. 2008
    ..These studies explored the effects of brief, repeated, prenatal toluene exposures in pregnant female rats on body weight, metabolic rate, body composition, and food intake in their ..
  100. ncbi Removal of BTEX vapours from waste gas streams using silica aerogels of different hydrophobicity
    Suzana Standeker
    Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia
    J Hazard Mater 165:1114-8. 2009
    ..The degree of hydrophobicity of the aerogels was tested by measuring the contact angle (theta) of a water droplet with the aerogel surface. The aerogels were also characterised by FTIR, nitrogen sorption and DSC/TG measurements...
  101. ncbi Adsorption of BTEX from aqueous solution by macroreticular resins
    S H Lin
    Department of Chemical Engineering, Yuan Ze University, Neili, Taoyuan 320, Taiwan
    J Hazard Mater 70:21-37. 1999
    Theoretical and experimental investigations were conducted on the adsorption of benzene, toluene, ethylbenzene and xylene (BTEX) by macroreticular resins...

Research Grants63

  1. Nonheme Diiron Centers and the Biological Oxidation of Hydrocarbons
    Stephen J Lippard; Fiscal Year: 2013
    ..Studies of both native and genetically modified systems, including soluble methane monooxygenase (sMMO), toluene/o-xylene monooxygenase (ToMO), and alkene monooxygenase (AMO), will enable us to elucidate the carefully ..
  2. Neural Actions of Toluene
    John J Woodward; Fiscal Year: 2013
    ..In this application, we focus on the role that these channels play in mediating the effects of toluene, the prototype abused inhalant, on the activity of principal neurons within three brain regions known to be ..
  3. Liquid Crystal-Based End-of-Service-Life-Indicator for Toluene Vapor
    BHARAT R ACHARYA; Fiscal Year: 2011
    ..g., ammonia), there are no commercial ESLIs available for organic vapors such as toluene. In the absence of ESLIs for organic vapors, NIOSH requires manufacturers to develop (and users to adopt) complex ..
  4. Understanding aromatic hydrocarbon uptake as the first step in biodegradation
    Bert van den Berg; Fiscal Year: 2013
    ..4. To determine which proteins are important during toluene biodegradation by PpF1...
  5. Neuroplasticity Associated with Acute Toluene Inhalation
    JACOB THOMAS BECKLEY; Fiscal Year: 2013
    ..b>Toluene, a prototypical abused inhalant, inhibits NMDA mediated currents and has an excitatory effect on GABA synaptic ..
  6. NMR SPECTROSCOPY OF IRON-SULFUR PROTEINS
    John L Markley; Fiscal Year: 2010
    ..transfer in three model biological systems (rubredoxin:FNR, stearoyl-acyl carrier protein desaturase, and toluene monooxygenase system);(3) to determine mechanisms of chaperone-assisted iron-sulfur cluster assembly in ..
  7. Imaging the causes and consequences of adolescent inhalant abuse
    Wynne K Schiffer; Fiscal Year: 2013
    ..We expect that brain regions where toluene accumulates will be selectively damaged, and that upon cessation from toluene, adolescents will recover function ..
  8. High-Spin Iron(IV)-oxo Complexes-True Mimics of Enzymatic Non-Heme Iron
    AIDAN RICHARD MCDONALD; Fiscal Year: 2010
    ..g. cyclohexane, toluene, and even methane) will give us a better understanding of the very complex reaction profiles these enzymes ..
  9. Bio-monitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden
    ADAM WISNEWSKI; Fiscal Year: 2010
    ..Three major types of isocyanate are used commercially, methylene-diphenyl diisocyanate (MDI) and toluene diisocyanate (TDI), or aliphatic, hexamethylene diisocyanate (HDI)...
  10. Neurotoxic effects of solvents on working children
    Iman A Nuwayhid; Fiscal Year: 2011
    ..A cohort of 100 male children (10-17 years) working in mechanics (exposed mainly to Methyl Ethyl Ketone and Toluene) and 100 male non-exposed working children will be recruited from a poor neighborhood in north Lebanon, in ..
  11. Reducing Chemical Exposures in Nail Salons Using an Owner-to-Worker Intervention
    THU THUY QUACH; Fiscal Year: 2010
    ..g., total hydrocarbons, toluene, formaldehyde and methyl methacrylate) in workers;and d) reducing work-related health problems...
  12. Bio-monitoring Methylene Diphenyl Diisocyanate (MDI) exposure and body burden
    ADAM WISNEWSKI; Fiscal Year: 2012
    ..Three major types of isocyanate are used commercially, methylene-diphenyl diisocyanate (MDI) and toluene diisocyanate (TDI), or aliphatic, hexamethylene diisocyanate (HDI)...
  13. Discriminative stimulus effects of abused inhalants
    Keith L Shelton; Fiscal Year: 2013
    ..In Aim 1 we will train groups of mice to discriminate one of four different inhalants from air: toluene, 1,1,1-trichlroethane (TCE), isoflurane or nitrous oxide...
  14. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2011
    ..Similarly, toluene or hexane will be used as a model solvent to test organophilic NF membranes...
  15. Novel Nanofiltration Membranes for Isolation of Pharmaceutical Compounds
    Ning Shangguan; Fiscal Year: 2012
    ..Similarly, toluene or hexane will be used as a model solvent to test organophilic NF membranes...
  16. Multiple Myeloma Consortium Study of Occupational Exposures and Family History
    Anneclaire J De Roos; Fiscal Year: 2013
    ..to five specific solvents of particular interest: trichloroethylene (TCE), perchloroethylene (PCE), benzene, toluene, and xylene...
  17. Reducing Workplace Chemical Exposures in Nail Salon Workers using an Owner-to-Wor
    THU THUY QUACH; Fiscal Year: 2013
    ..g., toluene, formaldehyde, methyl methacrylate and total volatile organic compounds) in workers; b)influencing the secondary ..
  18. Continued Development of Photoelectrocatalytic Oxidation for Treating Gasoline Co
    TERENCE PATRICK BARRY; Fiscal Year: 2012
    ..are of particular concern: (1) aromatic hydrocarbons, particularly the BTEX chemicals benzene, ethyl benzene, toluene, and three isomers of xylene, and (2) fuel oxygenates, particularly methyl tert-butyl ether (MTBE)...
  19. A Wearable Wireless System for Real-Time Monitoring of Chemical Toxicants
    Nongjian Tao; Fiscal Year: 2010
    ..two particularly exciting new opportunities: 1 )development of a new hybrid detection method for Benzene, Toluene, Ethylbenzene and Xylenes (BTEX) that can provide unparalleled performance for determining personal exposure ..
  20. Understanding hydrogen atom transfer reactions in enzymes
    E NEIL MARSH; Fiscal Year: 2013
    ..Benzylsuccinate synthase is a glycyl-radical enzyme in which hydrogen transfer from toluene to an active site cysteine is a key mechanistic feature...
  21. Electronic Structure and Reactions of Fe-oxo Enzymes
    Louis Noodleman; Fiscal Year: 2010
    ..The specific enzymes of interest are Class I ribonucleotide reductases (RNRs) methane monooxygenases (MMOs), toluene monoxygenases (Tolos) and Rieske oxygenases...
  22. Mechanistic Investigations of Gold-Catalyzed C-H Activation of Arenes
    David A Nagib; Fiscal Year: 2013
    ..that of other transition metals, as it can be accessed directly via para C-H activation to simple arenes such as toluene, potentially providing access to diverse para- substituted arene products...
  23. CYTOCHROME P450 SUBSTRATE SITING AND MOTION
    Ann McDermott; Fiscal Year: 2002
    ..We propose to characterize substrate motion for additional substrates (camphor, benzene, toluene, xylene, nicotine and warfarin), and an additional stable intermediate of the enzymatic cycle...
  24. Acute and Chronic Effects of Inhalants in ICSS
    MATTHEW ED TRACY; Fiscal Year: 2013
    ..basic behavioral procedures for assessing abuse-related effects of two prototypic inhalants in these procedures: toluene and nitrous oxide. Our first goal will be to examine the acute rewarding effects of these inhalants...
  25. A novel desorption technique for improved sensitivity in sampling for gases
    CLAUDIU T LUNGU; Fiscal Year: 2013
    ..We will use the irradiation scenario that yields the highest temperature increase, load the substrates with toluene vapors and determine the amount of desorbed toluene for each irradiation/substrate/loading combination...
  26. DRUG SELF-ADMINISTRATION BY INHALATION IN THE PRIMATE
    Ronald Wood; Fiscal Year: 1991
    ..behaviors are more sensitive than unconditioned behavior, and m-xylene is more potent than the less lipophilic toluene. In the mouse, however, the solvents are qualitatively different, and the order of potency reversed; m-xylene is ..
  27. Dense Medium Plasma Remediation of VOCs in Groundwater
    Yonghui Ma; Fiscal Year: 2007
    ..demonstrated that the DMP reactor, prior to any optimization, was able to reduce VOC concentrations of benzene, toluene, ethyl benzene, and xylene (all) below the detectable range (from ppm to ppb) and bacteria contamination levels ..
  28. Extreme Ammonia Tolerance Mechanisms: A Model Vertebrate
    Patrick Walsh; Fiscal Year: 2004
    ..In particular, liver damage due to exposure to toxicants such as carbon tetrachloride, toluene, DDT, heptachlor, etc...
  29. TOXICOLOGICAL SIGNIFICANCE OF ALKYLBENZENE METABOLISM
    Wayne Backes; Fiscal Year: 1992
    ..The compounds to ,e examined in this proposal, toluene, the xylenes, ethylbenzene and n-propylbenzene are major components of gasoline comprising up to 40% of the ..
  30. O2 ACTIVATION BY MOSSBAUER SPECTROSCOPY
    Eckard Munck; Fiscal Year: 2002
    ..1) Studies of the diiron proteins methane monooxygenase, ribonucleotide reductase, delta9 desaturase, toluene monooxygenase, phenol hydroxylase and alkane hydroxylase will be continued with particular focus on ..
  31. Molecular Characterization of Aquifer Microbial Communi*
    Kate Scow; Fiscal Year: 2004
    ..Superfund chemicals, toluene, benzene and xylene, along with fuel oxygenates, comprise mixed contaminants associated with petroleum pollution...
  32. A Photoelectrocatalytic Device for Removing MTBE from Water
    Terence Barry; Fiscal Year: 2009
    ..Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene, and three isomers of xylene, and (2) fuel oxygenates, particularly methyl tert-butyl ether (MTBE)...
  33. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..The first part of this study demonstrated that the dermal absorption of toluene in an aqueous matrix was substantially less than previous estimates, and that aqueous methyl ethyl ketone was ..
  34. BEHAVIORAL PHARMACOLOGY OF ABUSED SOLVENTS
    Robert Balster; Fiscal Year: 1992
    ..those classes which appear to produce qualitatively different effects from the depressant-like inhalants such as toluene and trichloroethane. This will include further research with the abused volatile nitrites...
  35. MECHANISMS OF ORGANIC SOLVENT OTOTOXICITY
    Laurence Fechter; Fiscal Year: 2001
    ..One pattern, produced by toluene, involves impairment of outer hair cells that normally encode middle frequency tones and which are located in the ..
  36. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    Striking phenotypic similarities have been noted between infants exposed to toluene in utero and infants diagnosed with fetal alcohol syndrome...
  37. MECHANISMS OF ENZYMATIC OXYGEN FIXATION
    David Gibson; Fiscal Year: 2003
    ..The genes encoding the enantiospecific toluene and naphthalene dihydrodiol dehydrogenases will be used to construct recombinant strains of Escherichia coli that ..
  38. How do Enzymes Generate and Control Free Radicals?
    E Marsh; Fiscal Year: 2007
    ..discovered glycyl radical enzyme, benzylsuccinate synthase, which is involved in the anaerobic degradation of toluene by various bacteria...
  39. CHARACTERIZING PSYCHOACTIVE EFFECTS OF INHALANTS
    James Zacny; Fiscal Year: 2004
    ..g., toluene and trichloroethane, which are contained in various commercial products including adhesives, aerosol sprays, and ..
  40. ANIMAL MODELS OF ASTHMA AND OCCUPATIONAL LUNG DISEASE
    Roy Patterson; Fiscal Year: 1991
    ..6. To develop a monkey model of toluene diisocyanate (TDI) asthma based on our human clinical experience in man and our experience with a canine model of ..
  41. BEHAVIORAL PHARMACOLOGY OF ABUSED SOLVENTS
    Robert Balster; Fiscal Year: 2002
    ..b>Toluene, trichloroethane (TCE), methoxyflurane, flurothyl and isoamyl nitrite will be evaluated in these new procedures...
  42. BIOANALYSIS USING COATED CRYSTAL ATR/FTIR METHODS
    STERLING TOMELLINI; Fiscal Year: 1992
    ..The test analytes initially chosen will include: nitrobenzene, acetophenone, acetonitrile, toluene, carbon tetrachloride, caffeine, acetylsalicylic acid and acetaminophen...
  43. Detection of Ethanol in Human Breath: Mini-GC Use and Exhaled Breath Condensate
    Richard Melker; Fiscal Year: 2007
    ..g., acetone, methanol, toluene) that may interfere with alternative technologies used to detect ethanol in breath...
  44. RESPIRATORY TRACT IRRITANTS; MECHANISMS AND TOLERANCE
    Yves Alarie; Fiscal Year: 1980
    ..the potency of airborne sensory irritants (gases or aerosols) is used to evaluate the cumulative effects of toluene diisocyanate and a variety of di- or monoisocyanates to elucidate the mechanism of such cumulative effects...
  45. TOXICOKINETICS OF ETHYL TERTIARY-BUTYL ETHER
    Crispin Pierce; Fiscal Year: 1999
    ..toxicokinetic (PBTK) modeling approach developed previously uses stable isotope tracers for styrene, toluene and xylene exposures, administered to male volunteers via inhalation...
  46. MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTS
    Ronald Thurman; Fiscal Year: 1991
    ..studies will then be applied to other hepatotoxins including pesticides, vinyl chloride, styrene, benzene and toluene. Knowledge of metabolic factors involved in mechanisms of hepatotoxicity in intact cells may ultimately be ..
  47. DNA METHYLATION EFFECTS ON MAMMALIAN DEVELOPMENT
    Stacy Branch; Fiscal Year: 2002
    ..This body of data includes the suggestions that compounds such as toluene and methyl parathion are associated with the induction of limb defects...
  48. ELECTRON PARAMAGNETIC RESONANCE SPECTROMETER
    Kurt Warncke; Fiscal Year: 2003
    ..in combination with Mossbauer spectroscopy, (c) the mechanism of biotransformation of aromatic hydrocarbons by toluene monooxygenases, by examining metal site structure in single crystals in combination with protein X-ray ..
  49. Novel Multiple-Component X-C/C-C Formation Reactions
    Guigen Li; Fiscal Year: 2003
    ..Besides the asymmetric catalysis, chiral p-toluene and tert-butanesulfinimines will also be utilized as the chiral auxiliaries and electrophiles for the novel X-C/C-..
  50. Enzyme Catalysis of Toluene Degradation and Unusual DNA Photoproduct Repair
    Lei Li; Fiscal Year: 2009
    ..BSS, found in bacteria like T. Aromatica, converts toluene to benzylsuccinate by a mechanism involving protein-based glycyl radical to initiate the toluene anaerobic ..
  51. Toluene as a Gateway Drug: Role of Dopamine Systems
    JEFFERY STEKETEE; Fiscal Year: 2004
    ..The long-term consequences ensuing from the abuse of inhalants, including toluene have received relatively little attention in the drug abuse field...
  52. DERMAL ABSORPTION OF CHEMICALS FROM LIQUID MIXTURES
    Annette Bunge; Fiscal Year: 2006
    ..i) examine experimentally the extent to which several test solutes in water and in four non-aqueous solutions (toluene, n-octanol, n-octane and a selected chlorinated hydrocarbon) interact with each other or skin to alter the rate [..
  53. NEUROLOGICAL SEQUELAE:CHRONIC TOLUENE INHALATION ABUSE
    Neil Rosenberg; Fiscal Year: 1991
    ..Inhalation of toluene-based products, such as spray paint or glue, is popular with solvent sniffers because of euphoric effects and ..
  54. Low Cost Multilayer Sensors for Breath Alcohol Analysis
    Stephanie Hooker; Fiscal Year: 2000
    ..To overcome cross-sensitivity to other gases that may be present in the breath (e.g., water vapor, acetone, toluene, and acetaldehyde), a sensor array will ultimately be prepared in Phase II...
  55. Abused inhalants and Drosphila K+ channel transcription
    Nigel Atkinson; Fiscal Year: 2003
    ..Furthermore, the acutely-resistant animals show cross-resistance to the abused solvent toluene. Concomitant with recovery we have observed that mANA from the slowpoke Ca2+-activated K+ channel gene increases ..
  56. ENVIRONMENTAL AGENTS EFFECT ON LUNG CILIARY DEFENSE
    Annette Hastie; Fiscal Year: 1990
    ..The focus of this proposal is the effects of formaldehyde (HCHO) and toluene diisocyanate (TDI) on ciliary function...
  57. Effects of Abused Inhalants on VTA neurons
    S V Jones; Fiscal Year: 2004
    ..grant proposal is to determine the actions of inhaled substances of abuse (inhalants) such as toluene on ventral tegmental area (VTA) dopaminergic neurons, part of the mesoaccumbens dopaminergic system...
  58. MECHANISMS RESPONSIBLE FOR DISEASE SEVERITY IN ASTHMA
    Stuart Brooks; Fiscal Year: 1980
    ..Occupational asthma due to toluene diisocyanate (TDI) seems to provide a good model for studying beta receptor function since in vitro studies with ..
  59. Miniature Sensor Platform for Detecting Toxic Gases
    CLAYTON KOSTELECKY; Fiscal Year: 2002
    ..Two demonstration gases will be characterized during Phase I, namely toluene and methanol...
  60. PET Investigations of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..Moreover, recent PET studies in our laboratory using carbon-11 labeled toluene (the most widely abused inhalant) support the value of this approach to advance our understanding of the ..
  61. AIR DISPERSION OF CHEMICALS IN INDUSTRIAL FACILITIES
    STEPHEN ZEMBA; Fiscal Year: 1992
    ..The model will be tested using industrial data for toluene diisocyanate and nitrogen dioxide, produced in polyurethane and steel cutting industries...
  62. 9th International Neurotoxicology Assoc (INA9) Meeting
    Michael Aschner; Fiscal Year: 2003
    ..neurotoxicity of polybrominated biphenylethers in development and adulthood; neurotoxic mechanisms and effects of toluene exposure; neurological diseases and consumption of plants; role of diet and nutrition in neurotoxicology; ..
  63. INHALANT ABUSE DURING GESTATION
    Sander Stern; Fiscal Year: 1999
    ..b>Toluene will be used in these initial studies since it is found in many of the mixtures abused via inhalation...