Genomes and Genes
Summary: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.
Publications302 found, 100 shown here
- Effects of prenatal exposure to styrene trimers on genital organs and hormones in male ratsKen Ichi Ohyama
Department of Environmental Health and Toxicology, Tokyo Metropolitan Research Institute of Public Health, 24 1, Hyakunincho 3 chome, Shinjuku ku, Tokyo 169 0073, Japan
Exp Biol Med (Maywood) 232:301-8. 2007b>Styrene trimers migrate from polystyrene food container into foods...
- Company-level, semi-quantitative assessment of occupational styrene exposure when individual data are not availableHenrik A Kolstad
Aarhus University Hospital, Department of Occupational Medicine, Aarhus, Denmark
Ann Occup Hyg 49:155-65. 2005..In this paper, we present a semi-quantitative exposure assessment strategy for nested case-control studies of styrene exposure among workers of the Danish reinforced plastics industry when no information on job title, task or other ..
- Genetic characterization of the styrene lower catabolic pathway of Pseudomonas sp. strain Y2Sergio Alonso
Department of Biochemistry and Molecular Biology, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040, Madrid, Spain
Gene 319:71-83. 2003Pseudomonas sp. strain Y2 is a styrene-degrading bacterium, which initiates the catabolism of this compound via its transformation into phenylacetate by the sequential oxidation of the vinyl side chain...
- Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damageAnnamaria Buschini
Department of Genetics, Anthropology, Evolution, University of Parma, Parma, Italy
Environ Mol Mutagen 41:243-52. 2003A cross-sectional study was carried out on 48 workers exposed to styrene and 14 unexposed healthy controls in order to investigate the genotoxic potential of styrene exposure...
- Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypesBlanca Laffon
Departmento Biología Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, A, Coruna, Spain
Toxicology 186:131-41. 2003b>Styrene is a monomer of great commercial interest; its polymers and copolymers are used in a wide range of applications...
- Production host selection for asymmetric styrene epoxidation: Escherichia coli vs. solvent-tolerant PseudomonasDaniel Kuhn
Laboratory of Chemical Biotechnology, Department of Biochemical and Chemical Engineering, Technische Universitat Dortmund, Emil Figge Str 66, 44221, Dortmund, Germany
J Ind Microbiol Biotechnol 39:1125-33. 2012..Asymmetric styrene epoxidation is an example of a reaction which is strongly dependent on the host cell owing to its requirement for ..
- Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noiseMariola Sliwinska-Kowalska
Department of Physical Hazards, Nofer Institute of Occupational Medicine, 8 St Teresa St, Lodz, 90 950 Poland
J Occup Environ Med 45:15-24. 2003Ototoxicity of styrene and the synergistic action of styrene and noise have been shown in rats. The respective data in humans are scarce and equivocal...
- Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposureB Laffon
, Facultad de Ciencias, , Spain
J Chromatogr B Biomed Sci Appl 753:385-93. 2001b>Styrene is rapidly metabolised to mandelic acid (MA) and phenylglyoxylic acid (PGA), which are excreted in urine...
- Natural formation of styrene by cinnamon mold floraJ L Lafeuille
McCormick France, McCormick Europe Central Analysis Laboratory, 84210 Carpentras, France
J Food Sci 74:M276-83. 2009..pure cinnamon samples of diverse origins showed that some samples were naturally contaminated with high levels of styrene, up to 524 microg/g...
- Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liverFujiko Hirasawa
Department of Biochemistry, Akita University School of Medicine, Akita 010 8543, Japan
Biomed Res 28:323-30. 2007..P450s) and antioxidant enzymes, we treated rats with gadolinium chloride (25 mg as Gd/kg body weight) 4 h after styrene (a multiple P450 inducer) treatment (600 mg/kg)...
- DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalationP Vodicka
Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 14220 4, Prague, Czech Republic
Chem Biol Interact 137:213-27. 2001Genotoxic and clastogenic effects of styrene were studied in mice. Male NMRI mice were exposed by inhalation to styrene in concentrations of 750 and 1500 mg/m3 for 21, 7, 3 and 1 days (6 h/day, 7 days/week)...
- Construction and characterization of a forward subtracted library of blue mussels Mytilus edulis for the identification of gene transcription signatures and biomarkers of styrene exposureO Diaz de Cerio
CBET Res Ctr Experimental Marine Biology and Biotechnology of Plentzia PIE UPV EHU and Zoology and Cell Biology Dept Science and Technology Fac, University of the Basque Country UPV EHU, Bilbao, Spain
Mar Pollut Bull 71:230-9. 2013..responses in the mussel Mytilus edulis exposed to the corrosive and putatively carcinogenic hydrocarbon styrene (3-5 ppm, 3days), a forward subtracted (SSH) cDNA library was produced...
- Serum hepatic biochemical activity in two populations of workers exposed to styreneC A Brodkin
Department of Medicine, University of Washington, Seattle, WA, USA
Occup Environ Med 58:95-102. 2001..by routinely available tests indicative of hepatocellular necrosis, cholestasis, or altered hepatic clearance of bilirubin, occur in association with low to moderate exposure to styrene commonly experienced in industrial production.
- Styrene-induced hearing loss: a membrane insultP Campo
Institut National de Recherche et de Securite, Laboratoire de Neurotoxicité, Vandoeuvre, France
Hear Res 154:170-80. 2001b>Styrene is an aromatic solvent widely used as a precursor for polystyrene plastics in many factories which produce glass-reinforced plastic. This solvent has been shown to disrupt the auditory system in both humans and animals...
- Dose-response implications of the University of Alabama study of lymphohematopoietic cancer among workers exposed to 1,3-butadiene and styrene in the synthetic rubber industryR L Sielken
Sielken and Associates Consulting Inc, Suite 230, 3833 Texas Avenue, Bryan, TX 77802, USA
Chem Biol Interact 135:637-51. 2001..Specifically, the maximum likelihood estimate of the EC(01) increases from EPA's 1.2 ppm to 2.8 ppm on the basis of the updated epidemiologic data and increases further to 15.1 ppm when the CMA's proposed changes are also incorporated...
- DNA single- and double-strand breaks by alkaline- and immuno-comet assay in lymphocytes of workers exposed to styreneMaria Enrica Fracasso
Department of Medicine and Public Health, Section of Pharmacology, University of Verona, Policlinico GB Rossi, P le Scuro 10, 37134 Verona, Italy
Toxicol Lett 185:9-15. 2009Occupational exposure to styrene was studied in 34 workers employed in the production of fiberglass-reinforced plastic sheets and compared to 29 unexposed healthy controls...
- Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industryE Delzell
Department of Epidemiology and International Health, University of Alabama at Birmingham School of Public Health, 517 Ryals Building, 1665 University Blvd, Birmingham, AL 35294, USA
Chem Biol Interact 135:515-34. 2001This study evaluated relations between exposure to 1,3-butadiene (BD), styrene (STY) and dimethyldithiocarbamate (DMDTC) and mortality from leukemia among synthetic rubber industry workers...
- Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient airJohannes G Filser
GSF Institute of Toxicology, Ingolstaedter Landstrasse 1, D 85764, Neuherberg, Germany
Toxicol Lett 126:1-18. 2002Concerns of a tumorigenic risk of styrene (ST) originate from the findings that styrene (ST) is metabolized to the genotoxic intermediate styrene-7,8-oxide (SO)...
- Electrospun mats from styrene/maleic anhydride copolymers: modification with amines and assessment of antimicrobial activityMilena Ignatova
Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad G Bonchev Bl 103A, 1113 Sofia, Bulgaria
Macromol Biosci 10:944-54. 2010New antimicrobial microfibrous electrospun mats from styrene/maleic anhydride copolymers were prepared...
- Low level occupational exposure to styrene: its effects on DNA damage and DNA repairSirilak Wongvijitsuk
Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok 10210, Thailand
Int J Hyg Environ Health 214:127-37. 2011The present study aimed to evaluate the effects of styrene exposure at levels below the recommended standards of the Threshold Limit Value (TLV-TWA(8)) of 20 ppm (ACGIH, 2004) in reinforced-fiberglass plastics workers...
- Cancer mortality of workers exposed to styrene in the U.S. Reinforced plastics and composite industryJames J Collins
Dow Chemical Company, Midland, MI 48674, USA
Epidemiology 24:195-203. 2013Epidemiologic studies have reported increased risk of lymphohematopoietic cancers, lung cancer, and pancreatic cancer after exposure to styrene, although findings across studies are not consistent.
- Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenaseKatja Otto
Institute of Biotechnology, ETHZ, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPT, CH 8093, Zurich, Switzerland
J Bacteriol 186:5292-302. 2004Pseudomonas sp. VLB120 uses styrene as a sole source of carbon and energy. The first step in this metabolic pathway is catalyzed by an oxygenase (StyA) and a NADH-flavin oxidoreductase (StyB)...
- Determination of urinary styrene metabolites in the general Italian population by liquid chromatography-tandem mass spectrometryPaola Manini
Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
Int Arch Occup Environ Health 77:433-6. 2004To apply mass spectrometry-based techniques for the determination of background levels of metabolites of widespread organic solvents, such as styrene, in unexposed subjects from the general population.
- Multistate reactivity in styrene epoxidation by compound I of cytochrome p450: mechanisms of products and side products formationDevesh Kumar
Department of Organic Chemistry and the Lise Meitner Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
Chemistry 11:2825-35. 2005Density functional theoretical calculations are used to elucidate the epoxidation mechanism of styrene with a cytochrome P450 model Compound I, and the formation of side products...
- Styrene removal from polluted air in one and two-liquid phase biotrickling filter: steady and transient-state performance and pressure drop controlEldon R Rene
Chemical Engineering Laboratory, Faculty of Sciences, University of La Coruna, Rúa da Fraga, 10, E 15008 La Coruña, Spain
Bioresour Technol 102:6791-800. 2011A Sporothrix variecibatus-inoculated biotrickling filter (BTF) was examined for styrene removal, without and with the addition of silicone oil, at different empty bed residence times. The highest elimination capacities (ECs) were 172...
- Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesisWei Cheng Huang
Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, Henry, Wellcome Building, PO Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom
Metallomics 3:410-6. 2011..J. Mol. Biol., 2007, 373, 633) and styrene. In this paper, additional mutations at Thr438 are shown to decrease the binding of and catalytic activity ..
- Mechanism of flavin transfer and oxygen activation by the two-component flavoenzyme styrene monooxygenaseAuric Kantz
Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 4163, USA
Arch Biochem Biophys 442:102-16. 2005b>Styrene monooxygenase (SMO) from Pseudomonas putida S12 is a two-component flavoenzyme composed of the NADH-specific flavin reductase, SMOB, and FAD-specific styrene epoxidase, SMOA...
- Less is more: reduced catechol production permits Pseudomonas putida F1 to grow on styreneKevin W George
Field of Environmental Toxicology, Cornell University, Ithaca, NY 14850, USA
Microbiology 158:2781-8. 2012Pseudomonas putida F1 is unable to grow on styrene due to the accumulation of 3-vinylcatechol, a toxic metabolite that is produced through the toluene degradation (tod) pathway and causes catechol-2,3-dioxygenase (C23O) inactivation...
- Hepatotoxicity and pneumotoxicity of styrene and its metabolites in glutathione S-transferase-deficient miceGary P Carlson
School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
Drug Chem Toxicol 34:440-4. 2011b>Styrene is known to be hepatotoxic and pneumotoxic in rodents, and these adverse effects are related to its metabolism...
- Simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene using high-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometryStefano Marchese
Dipartimento di Chimica, Universita La Sapienza di Roma, Piazzale Aldo Moro n degrees 5, PO Box 34, Posta 62, 00185 Rome, Italy
Rapid Commun Mass Spectrom 18:265-72. 2004..LC/MS/MS) for the simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene in human urine specimens and standard solutions is described...
- Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humansGary P Carlson
School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, United States
Toxicology 254:1-10. 2008b>Styrene is widely used with significant human exposure, particularly in the reinforced plastics industry...
- Impairments of colour vision induced by organic solvents: a meta-analysis studyGalina V Paramei
Institute of Medical Psychology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
Neurotoxicology 25:803-16. 2004The impairment of colour discrimination induced by occupational exposure to toluene, styrene and mixtures of organic solvents is reviewed and analysed using a meta-analytical approach...
- Heterogeneity in styrene-butadiene latex filmsJuliane P Santos
Institute of Chemistry, Universidade Estadual de Campinas, P O Box 6154, 13083 970 Campinas SP, Brazil
Langmuir 20:10576-82. 2004Low-Tg styrene-butadiene (SB) latex films were investigated by noncontact atomic force microscopy and scanning electric potential microscopy, revealing a number of different morphologies and electric potential patterns across films cast ..
- Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activationCarmen Röder-Stolinski
UFZ Helmholtz Centre for Environmental Research, Department of Environmental Immunology, Permoserstrasse 15, D 04318 Leipzig, Germany
Toxicol Appl Pharmacol 231:241-7. 2008b>Styrene is a volatile organic compound (VOC) that is widely used as a solvent in many industrial settings. Chronic exposure to styrene can result in irritation of the mucosa of the upper respiratory tract...
- Styrene maleic acid-pirarubicin disrupts tumor microcirculation and enhances the permeability of colorectal liver metastasesJurstine Daruwalla
Department of Surgery, University of Melbourne, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
J Vasc Res 46:218-28. 2009..Pirarubicin, derived from doxorubicin, selectively targets tumors when encapsulated in styrene maleic acid (SMA), forming the macromolecular SMA pirarubicin...
- Disposition of styrene-acrylonitrile (SAN) trimer in female rats: single dose intravenous and gavage studiesMichael L Gargas
The Sapphire Group, Dayton, OH 45431, USA
Toxicol Lett 178:1-8. 2008b>Styrene-acrylonitrile trimer (SAN Trimer), a mixture of six isomers (four isomers of 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers of 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]..
- Leaching of styrene and other aromatic compounds in drinking water from PS bottlesMaqbool Ahmad
Environmental Control Department, Directorate General for Royal Commission at Yanbu, P O Box 30031 Yanbu Al Sinaiyah, Kingdom of Saudi Arabia
J Environ Sci (China) 19:421-6. 2007Bottled water may not be safer, or healthier, than tap water. The present studies have proved that styrene and some other aromatic compounds leach continuously from polystyrene (PS) bottles used locally for packaging...
- Production in food of 1,3-pentadiene and styrene by Trichoderma speciesS E Pinches
Biosciences, Council for Scientific and Industrial Research CSIR, PO Box 395, Pretoria 0001, South Africa
Int J Food Microbiol 116:182-5. 2007..of two strains of Trichoderma, isolated from food, to produce the Volatile Organic Compounds 1,3-pentadiene and styrene was investigated...
- Metabolism of phenylalanine and biosynthesis of styrene in Penicillium camembertiYves Pagot
UMR de Microbiologie et Génétique Moléculaire, Institut National Agronomique Paris Grignon, UMR INRA 537, URA CNRS 1925, F 78850 Thiverval Grignon France
J Dairy Res 74:180-5. 2007The occurrence of styrene in food may be an important aroma defect (celluloid odour), even at very low concentrations (Miltz et al. 1980) causing consumer rejection and is therefore a problem for the food industry...
- Effects of styrene and styrene oxide on glutathione-related antioxidant enzymesGary P Carlson
School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
Toxicology 227:217-26. 2006b>Styrene is both hepatotoxic and pneumotoxic in mice. Its mode of action is not clear, but it may be related to oxidative stress including a very large decrease in reduced glutathione (GSH)...
- Strain of Fusarium oxysporum isolated from almond hulls produces styrene and 7-methyl-1,3,5-cyclooctatriene as the principal volatile componentsJohn J Beck
Western Regional Research Center, U S Department of Agriculture, Albany, California 94710, USA
J Agric Food Chem 56:11392-8. 2008..the hulls of Prunus dulcis (sweet almond) was found to produce relatively large quantities of the hydrocarbons styrene and two isomers of 7-methyl-1,3,5- cyclooctatriene (MCOT)...
- Analysis of acrylonitrile, 1,3-butadiene, and related compounds in acrylonitrile-butadiene-styrene copolymers for kitchen utensils and children's toys by headspace gas chromatography/mass spectrometryHiroyuki Ohno
Nagoya City Public Health Research Institute, Environmental Health Department, 1 11, Hagiyama cho, Mizuho ku, Nagoya 467 8615, Japan
J AOAC Int 93:1965-71. 2010..their related compounds containing propionitrile (PN) and 4-vinyl-1-cyclohexene (4-VC) in acrylonitrile-butadiene-styrene (ABS) copolymers for kitchen utensils and children's toys...
- Removal of styrene vapor from waste gases by a trickle-bed air biofilterC Lu
Department of Environmental Engineering, National Chung Hsing University, Taichung 402, Taiwan ROC
J Hazard Mater 82:233-45. 2001The trickle-bed air biofilter (TBAB) performance for the removal of high-strength styrene was evaluated under different gas flow rates and influent concentrations...
- Biodegradation of gaseous styrene by Brevibacillus sp. using a novel agitating biotrickling filterJae Woong Hwang
Technical Consulting Team, Environmental Management Corporation, Incheon, 404 708, Korea
Biotechnol Lett 30:1207-12. 2008..biomass accumulation, the agitating biotrickling filter (ABTF) system, was developed for treatment of gaseous styrene using Brevibacillus sp...
- Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolitesJill A Harvilchuck
School of Health Sciences, Purdue University, West Lafayette, IN 47907 2051, USA
Toxicology 264:171-8. 2009In mice, styrene is hepatotoxic, pneumotoxic, and causes lung tumors. One explanation for the mechanism of toxicity is oxidative stress/damage...
- Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workersJ Slyskova
Department of Experimental and Applied Genetics, Research Base of Slovak Medical University, Bratislava, Slovak Republic
Mutat Res 634:101-11. 2007Genotoxic effects related to exposure to styrene have been a matter of investigation for many years by employing markers of exposure, effect and susceptibility...
- Determination of volatile organic compounds in biological samples using headspace solid-phase microextraction and gas chromatography: toluene and styreneRadhika Barua
Department of Clinical and Laboratory Sciences, SUNY at Buffalo, Buffalo, New York, USA
J Anal Toxicol 32:379-86. 2008Epidemiological and laboratory investigations have shown that toluene and styrene are toxic compounds that lead to impairment of the nervous system...
- Guidance of neurite outgrowth on aligned electrospun polypyrrole/poly(styrene-beta-isobutylene-beta-styrene) fiber platformsXiao Liu
ARC Centre of Excellence for Electromaterials Science, University of Wollongong, Wollongong NSW, Australia
J Biomed Mater Res A 94:1004-11. 2010..work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-beta-isobutylene-beta-styrene) (SIBS) fibers...
- Kinetics of styrene biodegradation in synthetic wastewaters using an industrial activated sludgeR Babaee
Chemical Engineering Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran, Iran
J Hazard Mater 184:111-7. 2010Kinetics of styrene biodegradation in synthetic wastewaters, containing either styrene or styrene together with ethanol, by an industrial activated sludge obtained from the wastewater treatment unit of a petrochemical complex was studied...
- Induction heating for surface triggering styrene polymerization on titanium modified with ATRP initiatorBastien Barthélémy
Laboratory of Chemistry and Electrochemistry of Surfaces CES, University of Namur FUNDP, rue de Bruxelles, 61, B 5000 Namur, Belgium
J Colloid Interface Sci 354:873-9. 2011..The present work aims to study the surface-initiated ATR polymerization of styrene on titanium substrates, using grafted 11-(2-bromoisobutyrate)-undecyl-1-phosphonic acid as initiator and to ..
- Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CPDirk Tischler
Environmental Microbiology, TU Bergakademie Freiberg, Freiberg, Germany
J Bacteriol 191:4996-5009. 2009..to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and phenylacetic acid...
- Bacterial degradation of styrene in waste gases using a peat filterM Arnold
VTT Chemical Technology, Finland
Appl Microbiol Biotechnol 48:738-44. 1997A biofiltration process was developed for styrene-containing off-gases using peat as filter material. The average styrene reduction ratio after 190 days of operation was 70% (max...
- CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumorsG Cruzan
ToxWorks, 1153 Roadstown Road, Bridgeton, NJ, USA
Regul Toxicol Pharmacol 62:214-20. 2012b>Styrene induces lung tumors in mice but not in rats. Although metabolism of styrene to 7,8-styrene oxide (SO) by CYP2E1 has been suggested as a mediator of styrene toxicity, lung toxicity is not attenuated in CYP2E1 knockout mice...
- Styrene degradation by Pseudomonas sp. SR-5 in biofilters with organic and inorganic packing materialsJ H Jang
Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, 226 8503, Japan
Appl Microbiol Biotechnol 65:349-55. 2004Pseudomonas sp. SR-5 was isolated as a styrene-degrading bacterium. In liquid culture containing 1% (v/v) styrene, more than 90% styrene was degraded in 53 h and the doubling time of SR-5 was 2 h...
- Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeksG Cruzan
ToxWorks, 1153 Roadstown Rd, Bridgeton, NJ 08302, USA
J Appl Toxicol 21:185-98. 2001Groups of 70 male and 70 female Charles River CD-1 mice were exposed whole body to styrene vapor at 0, 20, 40, 80 or 160 ppm 6 h per day 5 days per week for 98 weeks (females) or 104 weeks (males)...
- Response of human cord blood cells to styrene exposure: evaluation of its effects on apoptosis and gene expression by genomic technologyCristina Diodovich
Laboratory of Hematotoxicology, ECVAM Institute for Health and Consumer Protection, JRC, Ispra, Italy
Toxicology 200:145-57. 2004b>Styrene is one of the most important monomers produced worldwide, and it finds major use in the production of polystyrene, acrylonitrile-butadiene-styrene resins and unsaturated polystyrene resins...
- Immobilization of lipase B from Candida antarctica on porous styrene-divinylbenzene beads improves butyl acetate synthesisNatália G Graebin
Biocatalysis and Enzyme Technology Lab, Institute of Food Science and Technology, Federal University of Rio Grande do Sul State, Av Bento Goncalves, ZC 91501 970, Porto Alegre, RS, Brazil
Biotechnol Prog 28:406-12. 2012A new biocatalyst of lipase B from Candida antarctica (MCI-CALB) immobilized on styrene-divinylbenzene beads (MCI GEL CHP20P) was compared with the commercial Novozym 435 (immobilized lipase) in terms of their performances as ..
- Biodegradation of gas-phase styrene using the fungus Sporothrix variecibatus: impact of pollutant load and transient operationEldon R Rene
Chemical Engineering Laboratory, Faculty of Sciences, University of La Coruna, Rua Alejandro de la Sota, 1, E 15008 La Coruña, Spain
Chemosphere 79:221-7. 2010Biofiltration of gas-phase styrene was studied using a newly isolated fungus Sporothrix variecibatus, in a perlite biofilter, at inlet concentrations and gas-flow rates ranging from 0.13 to 14 g m(-3) and 0.075 to 0...
- Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthaleneMichael J Lanosa
Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
Toxicol Sci 115:589-95. 2010..transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene...
- Human neurobehavioral effects of long-term exposure to styrene: a meta-analysisVernon A Benignus
Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
Environ Health Perspect 113:532-8. 2005Many reports in the literature suggest that long-term exposure to styrene may exert a variety of effects on the nervous system, including increased choice reaction time and decreased performance of color discrimination and color ..
- Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditionsJasmina Nikodinovic-Runic
School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
Microbiology 155:3348-61. 2009Pseudomonas putida CA-3 is a styrene-degrading bacterium capable of accumulating medium-chain-length polyhydroxyalkanoate (mclPHA) when exposed to limiting concentrations of a nitrogen source in the growth medium...
- Cumulative exposure to styrene and visual functionsL Castillo
, , , , Canada
Am J Ind Med 39:351-60. 2001..from a 1990-1992 longitudinal study of several reinforced plastics plants showed that for those workers whose styrene exposure had decreased, color vision (CV) improved; while near visual contrast sensitivity (CS) was poorer...
- Styrene biosynthesis from glucose by engineered E. coliRebekah McKenna
Chemical Engineering, Arizona State University, 501 E Tyler Mall, Tempe, AZ 85287 6106, USA
Metab Eng 13:544-54. 2011b>Styrene is a large volume, commodity petrochemical with diverse commercial applications, including as a monomer building-block for the synthesis of many useful polymers...
- Syntheses, characterization and study of the use of cobalt (II) Schiff-base complexes as catalysts for the oxidation of styrene by molecular oxygenAli Akbar Khandar
Department of Inorganic Chemistry, Faculty of Chemistry, Tabriz University, Tabriz, Iran
Molecules 10:302-11. 2005..These complexes catalyze the oxidation of styrene in the presence of dioxygen and excess pyridine...
- Thyroid function and exposure to styreneFerruccio Santini
Department of Endocrinology and Kidney, University Hospital of Pisa, Pisa, Italy
Thyroid 18:1065-9. 2008..The aim of this study was to evaluate the effects of styrene on the thyroid axis in occupationally exposed workers.
- Genetic and functional analysis of the styrene catabolic cluster of Pseudomonas sp. strain Y2A Velasco
Department of Molecular Microbiology, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
J Bacteriol 180:1063-71. 1998The chromosomal region of Pseudomonas sp. strain Y2 involved in the conversion of styrene to phenylacetate (upper catabolic pathway) has been cloned and sequenced...
- Shape-dependent catalytic activity of silver nanoparticles for the oxidation of styreneRun Xu
Department of Chemistry, Tsinghua University, Beijing, 100084, PR China
Chem Asian J 1:888-93. 2006..silver nanoparticles was compared with that of cubic and near-spherical silver nanoparticles in the oxidation of styrene in colloidal solution...
- Exposure to styrene in fiberglass-reinforced plastic manufacture: still a problemBruno Papaleo
INAIL, ex ISPESL Department of Occupational Medicine, Monte Porzio Catone, Italy
J Occup Environ Med 53:1273-8. 2011The aim of the work is to define occupational exposure to styrene in fiberglass manufacture; the phase of stretching styrene resins needs some manual handling and leads workers to be exposed to styrene.
- Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanismNora Mörbt
Department of Proteomics, UFZ, Helmholtz Centre for Environmental Research, Leipzig, Germany
Proteomics 9:4920-33. 2009b>Styrene is a volatile organic compound that is widely used as an intermediate in many industrial settings...
- Ototoxicity of toluene and styrene: state of current knowledgePerrine Hoet
Industrial Toxicology Unit, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
Crit Rev Toxicol 38:127-70. 2008..The main objective of this review was to analyze the available scientific literature on the ototoxic effects of styrene and toluene, in order to examine dose-response/effect relationships and the relevance of the prevention strategy ..
- Cochlear injuries induced by the combined exposure to noise and styreneGuang Di Chen
Center for Hearing and Deafness, SUNY at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
Hear Res 254:25-33. 2009..A noise band of 10-20 kHz was used to induce a cochlear injury in the same cochlear region in the rat as styrene exposure...
- Characteristics of styrene degradation by Rhodococcus pyridinovorans isolated from a biofilterIn Gyung Jung
Industrial Liaison Research Institute, Kyung Hee University, Yongin 449 701, South Korea
Chemosphere 61:451-6. 2005A novel strain (PYJ-1) of Rhodococcus pyridinovorans that was isolated from a biofilter was able to degrade styrene at a maximum rate of 0.16 mg (mg protein)(-1) h(-1) in batch culture at 97 mg l(-1) of initial styrene gas concentration...
- Performance of a styrene-degrading biofilter inoculated with Pseudomonas sp. SR-5Jong Hee Jang
Chemical Resources Laboratory, Tokyo Institute of Technology, R1 29 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
J Biosci Bioeng 100:297-302. 2005b>Styrene removal was studied for 3 months in a laboratory-scale biofilter packed with a mixed packing material of peat and ceramic at a ratio of 1 to 1 on a dry-weight basis and inoculated with Pseudomonas sp. SR-5...
- Effects of subchronic exposure to styrene on the extracellular and tissue levels of dopamine, serotonin and their metabolites in rat brainF Gagnaire
Département Polluants et Santé, Institut National de Recherche et de Securite, Avenue de Bourgogne, BP 27, 54501, Vandoeuvre Cedex, France
Arch Toxicol 80:703-12. 2006At present, there is controversy over the neurotoxic potential of styrene. Several epidemiological and clinical studies have shown that styrene exposure causes alterations of central nervous system functions in humans...
- Styrene lower catabolic pathway in Pseudomonas fluorescens ST: identification and characterization of genes for phenylacetic acid degradationPatrizia Di Gennaro
Department of Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, 20126, Milan, Italy
Arch Microbiol 188:117-25. 2007Pseudomonas fluorescens ST is a styrene degrading microorganism that, by the sequential oxidation of the vinyl side chain, converts styrene to phenylacetic acid...
- Audiological findings in workers exposed to styrene alone or in concert with noiseAnn Christin Johnson
Karolinska Institutet, Section of Audiology, Department of Clinical Science, Intervention and Technique, Alfred Nobels Alle 10, S 141 83 Stockholm, Sweden
Noise Health 8:45-57. 2006Audiological testing, interviews and exposure measurements were used to collect data on the health effects of styrene exposures in 313 workers from fiberglass and metal-product manufacturing plants and a mail terminal...
- Styrene-catabolism regulation in Pseudomonas fluorescens ST: phosphorylation of StyR induces dimerization and cooperative DNA-bindingLivia Leoni
Dipartimento di Biologia, Universita Roma Tre, Viale G Marconi 446, I 00146 Rome, Italy
Biochem Biophys Res Commun 303:926-31. 2003b>Styrene is an important chemical extensively used in the petrochemical and polymer industries...
- Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurementsAndreas Seeber
Institute of Occupational Physiology at the University of Dortmund, Dortmund, Germany
Int Arch Occup Environ Health 82:969-84. 2009Associations between occupational styrene exposure and cognitive as well as psychomotor functions were investigated with a view to answering three questions: (1) are the published results for neurobehavioural impairment reproducible, (2) ..
- Temporal processing disorder associated with styrene exposureEwa Zamyslowska-Szmytke
Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, PL 91 348 Łódź, Poland
Audiol Neurootol 14:296-302. 2009Little evidence exists on the possible adverse effects of styrene on the central part of the auditory system. The present investigation aimed to study the possible association between styrene exposure and temporal processing abilities...
- Transcriptional regulation of styrene degradation in Pseudomonas putida CA-3W Duetz
Microbiology Department, National University of Ireland, Cork, Ireland
Microbiology 147:973-9. 2001The styrene degradative pathway in Pseudmonas putida CA-3 has previously been shown to be divided into an upper pathway involving the conversion of styrene to phenylacetic acid and a lower pathway for the subsequent degradation of ..
- Audiometric findings in workers exposed to low levels of styrene and noiseThais C Morata
National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio 45226, USA
J Occup Environ Med 44:806-14. 2002..Workers exposed to noise and styrene had significantly worse pure-tone thresholds at 2, 3, 4, and 6 kHz when compared with noise-exposed or nonexposed ..
- Effect of multiple doses of styrene and R-styrene oxide on CC10, bax, and bcl-2 expression in isolated Clara cells of CD-1 miceJill A Harvilchuck
School of Health Sciences, Purdue University, Civil Engineering Building, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
Toxicology 259:149-52. 2009b>Styrene exposure is highest among workers in the reinforced plastics industry with exposure seen for 5 consecutive days during the work week. Styrene is both hepatotoxic and pneumotoxic in mice, in addition to causing lung tumors...
- Relation between outer hair cell loss and hearing loss in rats exposed to styreneGuang Di Chen
Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY 14214, USA
Hear Res 243:28-34. 2008..b>Styrene is an ototoxic agent, which targets and destroys OHCs starting from the third row to the second and first rows ..
- Microbial degradation of styrene: biochemistry, molecular genetics, and perspectives for biotechnological applicationsAisling Mooney
Centre for Synthesis and Chemical Biology, School of Biomolecular and Biomedical Sciences, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
Appl Microbiol Biotechnol 72:1-10. 2006Large quantities of the potentially toxic compound styrene are produced and used annually by the petrochemical and polymer-processing industries...
- Occupational styrene exposure and hearing loss: a cohort study with repeated measurementsGerhard Triebig
Institute and Outpatient Clinic for Occupational and Social Medicine, University Hospital of Heidelberg, Vossstrasse 2, Heidelberg, Germany
Int Arch Occup Environ Health 82:463-80. 2009Associations between occupational styrene exposure and impairment of hearing function were investigated, guided by three questions: are there hearing losses concerning high frequency and standard audiometric test? Are there dose-response ..
- Accumulation of polyhydroxyalkanoate from styrene and phenylacetic acid by Pseudomonas putida CA-3Patrick G Ward
Department of Industrial Microbiology, Centre for Synthesis and Chemical Biology, Conway Institute for Biomolecular and Biomedical Research, National University of Ireland, University College Dublin, Belfield, Dublin 4, Republic of Ireland
Appl Environ Microbiol 71:2046-52. 2005Pseudomonas putida CA-3 is capable of converting the aromatic hydrocarbon styrene, its metabolite phenylacetic acid, and glucose into polyhydroxyalkanoate (PHA) when a limiting concentration of nitrogen (as sodium ammonium phosphate) is ..
- Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an updateAvima M Ruder
The National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
Am J Ind Med 45:165-76. 2004Mortality was updated through 1998 for 5,204 workers exposed to styrene between 1959 and 1978 at two reinforced plastic boatbuilding plants. The a priori hypothesis: leukemia and lymphoma excesses would be found.
- Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1João P Teixeira
National Institute of Health, Environmental Health and Toxicology Department, Largo 1 de Dezembro, 4000 Porto, Portugal
Toxicology 195:231-42. 2004b>Styrene is widely used in the production of various plastics, synthetic rubber and resins...
- Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workersMaurizio Macaluso
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL, USA
J Occup Environ Hyg 1:371-90. 2004Quantitative estimates of exposure to 1,3-butadiene (BD), styrene (STY), and dimethyldithiocarbamate (DMDTC) were developed for a follow-up study of workers at six North American synthetic rubber plants...
- Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workersLode Godderis
Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
Environ Mol Mutagen 44:293-303. 2004A study on 44 workers exposed to styrene and 44 matched referents was performed in order to examine the influence of genetic polymorphisms in biotransformation and DNA repair enzymes on the levels of N-terminal hemoglobin adducts and ..
- Dual role of response regulator StyR in styrene catabolism regulationLivia Leoni
Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
Appl Environ Microbiol 71:5411-9. 2005In Pseudomonas fluorescens ST, the promoter of the styrene catabolic operon, PstyA, is induced by styrene and repressed by the addition of preferred carbon sources. PstyA is regulated by the StyS/StyR two-component system...
- Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (europe)Ghislaine Scelo
International Agency for Research on Cancer, Lyon 69008, France
Cancer Causes Control 15:445-52. 2004..cohort studies have addressed the risk of lung cancer following exposure to vinyl chloride, acrylonitrile and styrene, with inconsistent results and usually without smoking adjustment...
- Coregulation by phenylacetyl-coenzyme A-responsive PaaX integrates control of the upper and lower pathways for catabolism of styrene by Pseudomonas sp. strain Y2Teresa del Peso-Santos
Department of Biochemistry and Molecular Biology, I, Facultad de Ciencias Biologicas, Universidad Complutense, 28040 Madrid, Spain
J Bacteriol 188:4812-21. 2006..strain Y2 controls expression of the styABCD genes, which are required for the conversion of styrene to phenylacetate, which is further catabolized by the products of two paa gene clusters...
- Genetic characterization of accumulation of polyhydroxyalkanoate from styrene in Pseudomonas putida CA-3Niall D O'Leary
Microbiology Department, National University of Ireland, Cork, Ireland
Appl Environ Microbiol 71:4380-7. 2005..capable of accumulating medium-chain-length polyhydroxyalkanoates (MCL-PHAs) when growing on the toxic pollutant styrene as the sole source of carbon and energy...
- Migration of styrene monomer, dimers and trimers from polystyrene to food simulantsJin Ok Choi
Kyungnam University, Division of Food Science and Biotechnology, Korea
Food Addit Contam 22:693-9. 2005..04 and 10.05 dm2 l(-1) for n-heptane and distilled water, respectively. Styrene monomer, styrene dimers and styrene trimers migrating to the food simulants were determined by GC-FID analysis...
- Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeysNirmal K Lohiya
Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
Contraception 71:214-26. 2005A preclinical evaluation for reversal through a noninvasive approach following long-term vas occlusion with styrene maleic anhydride (SMA) has been attempted in langur monkeys at the level of semen parameters, sperm functional tests, ..
- Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industryM Macaluso
Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294 2170, USA
Toxicology 113:190-202. 1996Retrospective, quantitative estimates of exposure to 1,3-butadiene, styrene and benzene were developed for a follow-up study of leukemia mortality among 16610 subjects employed at six North American styrene-butadiene rubber manufacturing ..
- Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styreneAlessio Naccarati
Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
Mutat Res 537:131-40. 2003Occupational exposure to styrene, a chemical extensively used worldwide, is under investigation for possible detrimental effects on human health, including male reproductive capacity...
- An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industryL A Nylander-French
Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
Ann Occup Hyg 43:99-105. 1999During the manufacturing of reinforced plastics, large amounts of styrene and trace quantities of styrene-7,8-oxide (SO) are released...
- Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytesSabrina Bernardini
Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
Carcinogenesis 23:893-7. 2002..null genotype was associated with increased induction of sister chromatid exchanges (SCEs) by a metabolite of styrene, styrene-7,8-oxide, in human lymphocyte cultures, while GSTM1 genotype had no effect...
- The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applicationsJ M Luengo
Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Leon, 24007 Leon, Spain
Mol Microbiol 39:1434-42. 2001..The phenylacetyl-CoA catabolon encompasses all the routes involved in the transformation of styrene, 2-phenylethylamine, trans-styrylacetic acid, phenylacetaldehyde, phenylacetic acid, phenylacetyl amides, ..
- ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATIONJames F Rusling; Fiscal Year: 2013..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines...
- CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENAL TOXICOLOGY PROGRAMReshan Fernando; Fiscal Year: 2010..In support of the carcinogenesis program, a low-level impurity screen was conducted on styrene acrylonitrile trimer looking for the presence of styrene and acrylonitrile mono- and dimers...
- Structure and Mechanisms of Styrene MonooxygenaseGeorge T Gassner; Fiscal Year: 2010DESCRIPTION (provided by applicant): Styrene is an important component of a wide array of plastic, rubber, and over the counter adhesive products...
- PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSUREGHULAM ANSARI; Fiscal Year: 1991..such as aldehyde (acrolein, formaldehyde, and glutaraldehyde), epoxide (ethylene oxide, propylene oxide, and styrene oxide), and hydrocarbon (benzene, styrene, and butadiene) will be used as model compounds for this study...
- Studies of Chemical Disposition in AnimalsGLENN I SIPES; Fiscal Year: 2009..TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure...
- Development of Extraocular Muscle Prosthesis for Paralytic StrabismusYasushi Kato; Fiscal Year: 2009..eye back to the primary position upon relaxation of the antagonist muscle;2) a novel biocompatible polymer, poly(styrene-block-isobutylene-block- styrene) or "SIBS," that does not elicit significant inflammatory reaction or ..
- RADIOPAQUE ADHESIVES AND DENTAL RESTORATIVE RESINSISRAEL CABASSO; Fiscal Year: 2000..To obtain reactive, radiopaque, adhesive resin components we wiU: optimize the yield of the bismuth-styrene derivatives, synthesize Sb-styrene monomers, synthesize the Bi, Ti, Zr, and Hf derivatives of vinylbenzyl ..
- Serum Inhibin B Levels in Male Polymer Production WorkerRichard Lewis; Fiscal Year: 2000..to lead and phthalate esters) and synthetic rubber production workers (exposed to acrylonitrile, butadiene, and styrene) will be analyzed for Inhibin B and FSH levels and compared with those from an age-matched control group (non-..
- Organic Solvent Mixtures & Neuropsychological OutcomesEllen Kirrane; Fiscal Year: 2002..known to be exposed to a variety of organic solvents including evaporative emissions from fuel and fuel exhaust, styrene and acetone during fiberglass work, paints and tars for waterproofing their traps...
- CASE CONTROL STUDY OF CANCER IN SYNTHETIC RUBBER WORKERGenevieve Matanoski; Fiscal Year: 1991..lymphopoietic, hematologic, and gastrointestinal cancers and sarcomas from occupational exposure to butadiene and styrene and to determine if a dose response exists. Butadiene is the 36th most common chemical produced in the U.S...
- SELECTIVE REAL-TIME DETECTION OF OLEFIN GASES AND VAPORSEDWARD ZELLERS; Fiscal Year: 1991..of each of the following olefin gases and vapors: acrylonitrile, butadiene, beta-chloroprene, ethylacrylate, styrene, vinyl chloride, and vinylidene chloride...
- PERIPHERAL MARKERS OF STYRENE TOXICITYHarvey Checkoway; Fiscal Year: 1990..potential to a human population exposed occupationally to a known and quantifiable neurotoxic agent, styrene. The specific aims of this research are: 1) to compare levels of dopamine D2 receptors, monoamine oxidase type B ..
- FIBER OPTIC SENSORS BASED ON POLMER SWELLINGRUDOLF SEITZ; Fiscal Year: 1999..Hydrophilicity will be controlled by preparing copolymers of styrene and 2,4,5- trichlorophenylacrylate (TCPA) followed by conversion of the TCPA to a more hydrophilic functional ..
- ULTRASENSITIVE METHODS FOR HUMAN DNA ADDUCT QUANTITATIONJames Swenberg; Fiscal Year: 2000..These adducts are formed in DNA from animals and humans exposed to vinyl chloride, simple alkylating agents and styrene oxide, and most can be demonstrated in DNA of unexposed animals and humans...
- Mechanistic studies of pulmonary toxicity of styreneJiang Zheng; Fiscal Year: 2010Wide range effects of occupational styrene exposure have been reported to cause severe acute toxic effects. Inhaled styrene has been found to produce respiratory toxicity in human and animals...
- Dermatopharmacokinetics: In Vivo Analysis of SolventsKarla Thrall; Fiscal Year: 2005..studies to evaluate the percutaneous absorption of compounds commonly encountered within similar industries (styrene and ethylbenzene) along with focused studies to evaluate the dermal bioavailability of compounds with both ..
- COLLABORATIVE STUDY OF 1,3 BUTADIENE BIOMARKERSThomas Smith; Fiscal Year: 2002..5-2 ppm full shift) during normal operations, and little concurrent exposure to styrene or acrylonitrite. Twenty tank cleaners will provide data on high exposure responses...
- Feto-Maternal Pharmacokinetics of Abused InhalantsSTEPHEN DEWEY; Fiscal Year: 2004..this fraction is 2% -4% for chlorinated hydrocarbons or for more highly substituted aromatics such as xylene and styrene. The proposed work builds on our previous extensive neuroimaging studies of drugs of abuse using positron ..
- Pd-Catalyzed Olefin Functionalization Reactions for Organic SynthesisMATTHEW SIGMAN; Fiscal Year: 2007..of styrenes containing a phenol, (2) develop and investigate Pd-catalyzed hydroalkoxylation reactions of styrene derivatives, (3) explore Pd-catalyzed cross-coupling reactions utilizing organometallic reagents paired with an ..
- MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTSRonald Thurman; Fiscal Year: 1991..gained in these studies will then be applied to other hepatotoxins including pesticides, vinyl chloride, styrene, benzene and toluene...
- RESPIRATORY TRACT IRRITANTS; MECHANISMS AND TOLERANCEYves Alarie; Fiscal Year: 1980..Benzoquinone, styrene, and styrene oxide will also be used...
- TOXICOKINETICS OF ETHYL TERTIARY-BUTYL ETHERCrispin Pierce; Fiscal Year: 1999..physiologically-based toxicokinetic (PBTK) modeling approach developed previously uses stable isotope tracers for styrene, toluene and xylene exposures, administered to male volunteers via inhalation...
- DOSE/RESPONSE FOR STYRENE EXPOSURESStephen Rappaport; Fiscal Year: 1992..the linkages between exposure, absorbed dose, and cytogenetic response resulting from occupational exposures to styrene in the reinforced-plastics industry...
- BLOOD INTERACTIONS OF TRIBLOCK COPOLYMERSJoseph Andrade; Fiscal Year: 1980..The styrene-butadiene-styrene (SBS) triblock copolymer series permits the control of micromorphology and, by selective ..
- EPOXIDE TOXICITY IN ALKENE METABOLISMJOSEPH SINSHEIMER; Fiscal Year: 1992..Compounds of interest are (a) polycyclic aromatic alkyl epoxides; (b) styrene oxide derivatives (c) diol epoxides and (d) epoxides related to fecapentaene...
- Peptide-Modified Sulfonated Styrene Block Copolymers for Vascular ApplicationsDAVID VACHON; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Functional Proteogenomics of MitochondriaPeter Oefner; Fiscal Year: 2005..The concordance of protein data with those obtained by means of human mRNA expression arrays and the functional genomic findings from yeast will be assessed. ..
- CHIP BASED QTL MAPPING IN ARABIDOPSISPeter Oefner; Fiscal Year: 2001..It is anticipated that experience gained on the mapping of QTLs in Arabidopsis will be very valuable for similar efforts in other eukaryotes, including human. ..
- Development of MIDI-Ray Implant for GlaucomaLeonard Pinchuk; Fiscal Year: 2008..pressure flow principle that limits flow and thereby prevents hypotony, 2) a novel biomaterial called poly(styrene-block-isobutylene-block-styrene) ( SIBS ) that does not form clinically significant scar tissue in the eye and 3) ..
- PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDSLARRY OVERMAN; Fiscal Year: 2009....
- SCREENING PLATELETS INTERACTIONS WITH SURFACE GRADIENTSVladimir Hlady; Fiscal Year: 2009....
- MECHANISM(S) OF CHEMICAL LEUKEMOGENESISRichard Irons; Fiscal Year: 2002..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
- DIRECT OBSERVATION OF INTERFACIAL PROCESSVladimir Hlady; Fiscal Year: 2001..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
- Immunization to Reduce Genital and Neonatal HerpesNigel Bourne; Fiscal Year: 2009..These study designs may become standard for preclinical evaluation of HSV vaccines. ..
- Morpholino Antisense Drugs for Hepatitis C VirusNigel Bourne; Fiscal Year: 2004..The proposed research, if successful, would lead to a application for Phase II funding to bring the use of PMOs into the HCV drug market and provide a well-tolerated, inexpensive alternative to current HCV treatments. ..
- BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBESJames F Rusling; Fiscal Year: 2010..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
- DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORSArun K Ghosh; Fiscal Year: 2010..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
- Multifunctional Block Copolymer Scaffolds for Bone RepairMarcus Weck; Fiscal Year: 2010..Optimization of the mechanical properties of the newly developed scaffolds will be part of a future application submission. ..
- ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUTRALPH DELFINO; Fiscal Year: 2001..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
- DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESESArun Ghosh; Fiscal Year: 2001..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
- SPECTROSCOPY OF BIOMEMBRANE MONOLAYERSRichard Dluhy; Fiscal Year: 2002..abstract_text> ..
- DIRECT OBSERVATION OF INTERFACIAL PROCESSVladimir Hlady; Fiscal Year: 2003..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
- Evaluation of Exposure Measurement ErrorElaine Symanski; Fiscal Year: 2004..abstract_text> ..
- Catalytic Processes for Selective Organic SynthesisGARY MOLANDER; Fiscal Year: 2005..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
- ISEA 2004 ConferenceJunfeng Zhang; Fiscal Year: 2004..abstract_text> ..
- A Novel Polymer Trileaflet Heart ValveLeonard Pinchuk; Fiscal Year: 2005..The primary outcome of Phase II will be the data required for an application to the FDA to obtain a Feasibility Investigational Device Exemption (IDE). Clinical trials will follow this approval. ..
- SYNTHESIS OF COCARCINOGENIC DITERPENESJAMES RIGBY; Fiscal Year: 2005..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
- Agilent 5973 GC/MS SystemGARY MOLANDER; Fiscal Year: 2002..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
- GSH: Protecting Ovarian Follicles from Oxidant InjuryUlrike Luderer; Fiscal Year: 2006..Finally, the research plan and career development activities outlined in this proposal will enable Dr. Luderer to successfully make the transition from mentored researcher to independent scientist-clinician. ..
- Pediatric Asthma, Particulate Air Pollution and NO2RALPH DELFINO; Fiscal Year: 2006..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
- SPECTROSCOPY OF BIOMEMBRANE MONOLAYERSRichard Dluhy; Fiscal Year: 2006..unreadable] [unreadable]..
- SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDSJAMES RIGBY; Fiscal Year: 2006..unreadable] [unreadable]..
- Development of an Orbital Tissue Expander for BabiesLeonard Pinchuk; Fiscal Year: 2003..Phase II will be geared toward long-term in vivo testing of the device, stepping up production of the orbital expander for commercialization, regulatory submissions and clinical testing. ..
- New Methods for the Synthesis of Neurological AgentsLARRY OVERMAN; Fiscal Year: 2008..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..