styrene

Summary

Summary: A colorless, toxic liquid with a strong aromatic odor. It is used to make rubbers, polymers and copolymers, and polystyrene plastics.

Top Publications

  1. ncbi Effects of prenatal exposure to styrene trimers on genital organs and hormones in male rats
    Ken Ichi Ohyama
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Research Institute of Public Health, 24 1, Hyakunincho 3 chome, Shinjuku ku, Tokyo 169 0073, Japan
    Exp Biol Med (Maywood) 232:301-8. 2007
  2. ncbi Company-level, semi-quantitative assessment of occupational styrene exposure when individual data are not available
    Henrik A Kolstad
    Aarhus University Hospital, Department of Occupational Medicine, Aarhus, Denmark
    Ann Occup Hyg 49:155-65. 2005
  3. ncbi Genetic characterization of the styrene lower catabolic pathway of Pseudomonas sp. strain Y2
    Sergio Alonso
    Department of Biochemistry and Molecular Biology, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040, Madrid, Spain
    Gene 319:71-83. 2003
  4. ncbi Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage
    Annamaria Buschini
    Department of Genetics, Anthropology, Evolution, University of Parma, Parma, Italy
    Environ Mol Mutagen 41:243-52. 2003
  5. ncbi Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes
    Blanca Laffon
    Departmento Biología Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, A, Coruna, Spain
    Toxicology 186:131-41. 2003
  6. ncbi Production host selection for asymmetric styrene epoxidation: Escherichia coli vs. solvent-tolerant Pseudomonas
    Daniel Kuhn
    Laboratory of Chemical Biotechnology, Department of Biochemical and Chemical Engineering, Technische Universitat Dortmund, Emil Figge Str 66, 44221, Dortmund, Germany
    J Ind Microbiol Biotechnol 39:1125-33. 2012
  7. ncbi Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise
    Mariola Sliwinska-Kowalska
    Department of Physical Hazards, Nofer Institute of Occupational Medicine, 8 St Teresa St, Lodz, 90 950 Poland
    J Occup Environ Med 45:15-24. 2003
  8. ncbi Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure
    B Laffon
    , Facultad de Ciencias, , Spain
    J Chromatogr B Biomed Sci Appl 753:385-93. 2001
  9. ncbi Natural formation of styrene by cinnamon mold flora
    J L Lafeuille
    McCormick France, McCormick Europe Central Analysis Laboratory, 84210 Carpentras, France
    J Food Sci 74:M276-83. 2009
  10. ncbi Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver
    Fujiko Hirasawa
    Department of Biochemistry, Akita University School of Medicine, Akita 010 8543, Japan
    Biomed Res 28:323-30. 2007

Detail Information

Publications302 found, 100 shown here

  1. ncbi Effects of prenatal exposure to styrene trimers on genital organs and hormones in male rats
    Ken Ichi Ohyama
    Department of Environmental Health and Toxicology, Tokyo Metropolitan Research Institute of Public Health, 24 1, Hyakunincho 3 chome, Shinjuku ku, Tokyo 169 0073, Japan
    Exp Biol Med (Maywood) 232:301-8. 2007
    b>Styrene trimers migrate from polystyrene food container into foods...
  2. ncbi Company-level, semi-quantitative assessment of occupational styrene exposure when individual data are not available
    Henrik A Kolstad
    Aarhus University Hospital, Department of Occupational Medicine, Aarhus, Denmark
    Ann Occup Hyg 49:155-65. 2005
    ..In this paper, we present a semi-quantitative exposure assessment strategy for nested case-control studies of styrene exposure among workers of the Danish reinforced plastics industry when no information on job title, task or other ..
  3. ncbi Genetic characterization of the styrene lower catabolic pathway of Pseudomonas sp. strain Y2
    Sergio Alonso
    Department of Biochemistry and Molecular Biology, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Ciudad Universitaria, 28040, Madrid, Spain
    Gene 319:71-83. 2003
    Pseudomonas sp. strain Y2 is a styrene-degrading bacterium, which initiates the catabolism of this compound via its transformation into phenylacetate by the sequential oxidation of the vinyl side chain...
  4. ncbi Genetic polymorphism of drug-metabolizing enzymes and styrene-induced DNA damage
    Annamaria Buschini
    Department of Genetics, Anthropology, Evolution, University of Parma, Parma, Italy
    Environ Mol Mutagen 41:243-52. 2003
    A cross-sectional study was carried out on 48 workers exposed to styrene and 14 unexposed healthy controls in order to investigate the genotoxic potential of styrene exposure...
  5. ncbi Individual sensitivity to DNA damage induced by styrene in vitro: influence of cytochrome p450, epoxide hydrolase and glutathione S-transferase genotypes
    Blanca Laffon
    Departmento Biología Celular y Molecular, Facultad de Ciencias, Universidade da Coruna, Campus A Zapateira s n, 15071, A, Coruna, Spain
    Toxicology 186:131-41. 2003
    b>Styrene is a monomer of great commercial interest; its polymers and copolymers are used in a wide range of applications...
  6. ncbi Production host selection for asymmetric styrene epoxidation: Escherichia coli vs. solvent-tolerant Pseudomonas
    Daniel Kuhn
    Laboratory of Chemical Biotechnology, Department of Biochemical and Chemical Engineering, Technische Universitat Dortmund, Emil Figge Str 66, 44221, Dortmund, Germany
    J Ind Microbiol Biotechnol 39:1125-33. 2012
    ..Asymmetric styrene epoxidation is an example of a reaction which is strongly dependent on the host cell owing to its requirement for ..
  7. ncbi Ototoxic effects of occupational exposure to styrene and co-exposure to styrene and noise
    Mariola Sliwinska-Kowalska
    Department of Physical Hazards, Nofer Institute of Occupational Medicine, 8 St Teresa St, Lodz, 90 950 Poland
    J Occup Environ Med 45:15-24. 2003
    Ototoxicity of styrene and the synergistic action of styrene and noise have been shown in rats. The respective data in humans are scarce and equivocal...
  8. ncbi Simultaneous high-performance liquid chromatographic determination of urinary mandelic and phenylglyoxylic acids as indirect evaluation of styrene exposure
    B Laffon
    , Facultad de Ciencias, , Spain
    J Chromatogr B Biomed Sci Appl 753:385-93. 2001
    b>Styrene is rapidly metabolised to mandelic acid (MA) and phenylglyoxylic acid (PGA), which are excreted in urine...
  9. ncbi Natural formation of styrene by cinnamon mold flora
    J L Lafeuille
    McCormick France, McCormick Europe Central Analysis Laboratory, 84210 Carpentras, France
    J Food Sci 74:M276-83. 2009
    ..pure cinnamon samples of diverse origins showed that some samples were naturally contaminated with high levels of styrene, up to 524 microg/g...
  10. ncbi Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver
    Fujiko Hirasawa
    Department of Biochemistry, Akita University School of Medicine, Akita 010 8543, Japan
    Biomed Res 28:323-30. 2007
    ..P450s) and antioxidant enzymes, we treated rats with gadolinium chloride (25 mg as Gd/kg body weight) 4 h after styrene (a multiple P450 inducer) treatment (600 mg/kg)...
  11. ncbi DNA adducts, strand breaks and micronuclei in mice exposed to styrene by inhalation
    P Vodicka
    Institute of Experimental Medicine, Academy of Sciences of Czech Republic, Videnska 1083, 14220 4, Prague, Czech Republic
    Chem Biol Interact 137:213-27. 2001
    Genotoxic and clastogenic effects of styrene were studied in mice. Male NMRI mice were exposed by inhalation to styrene in concentrations of 750 and 1500 mg/m3 for 21, 7, 3 and 1 days (6 h/day, 7 days/week)...
  12. ncbi Construction and characterization of a forward subtracted library of blue mussels Mytilus edulis for the identification of gene transcription signatures and biomarkers of styrene exposure
    O Diaz de Cerio
    CBET Res Ctr Experimental Marine Biology and Biotechnology of Plentzia PIE UPV EHU and Zoology and Cell Biology Dept Science and Technology Fac, University of the Basque Country UPV EHU, Bilbao, Spain
    Mar Pollut Bull 71:230-9. 2013
    ..responses in the mussel Mytilus edulis exposed to the corrosive and putatively carcinogenic hydrocarbon styrene (3-5 ppm, 3days), a forward subtracted (SSH) cDNA library was produced...
  13. pmc Serum hepatic biochemical activity in two populations of workers exposed to styrene
    C A Brodkin
    Department of Medicine, University of Washington, Seattle, WA, USA
    Occup Environ Med 58:95-102. 2001
    ..by routinely available tests indicative of hepatocellular necrosis, cholestasis, or altered hepatic clearance of bilirubin, occur in association with low to moderate exposure to styrene commonly experienced in industrial production.
  14. ncbi Styrene-induced hearing loss: a membrane insult
    P Campo
    Institut National de Recherche et de Securite, Laboratoire de Neurotoxicité, Vandoeuvre, France
    Hear Res 154:170-80. 2001
    b>Styrene is an aromatic solvent widely used as a precursor for polystyrene plastics in many factories which produce glass-reinforced plastic. This solvent has been shown to disrupt the auditory system in both humans and animals...
  15. ncbi Dose-response implications of the University of Alabama study of lymphohematopoietic cancer among workers exposed to 1,3-butadiene and styrene in the synthetic rubber industry
    R L Sielken
    Sielken and Associates Consulting Inc, Suite 230, 3833 Texas Avenue, Bryan, TX 77802, USA
    Chem Biol Interact 135:637-51. 2001
    ..Specifically, the maximum likelihood estimate of the EC(01) increases from EPA's 1.2 ppm to 2.8 ppm on the basis of the updated epidemiologic data and increases further to 15.1 ppm when the CMA's proposed changes are also incorporated...
  16. ncbi DNA single- and double-strand breaks by alkaline- and immuno-comet assay in lymphocytes of workers exposed to styrene
    Maria Enrica Fracasso
    Department of Medicine and Public Health, Section of Pharmacology, University of Verona, Policlinico GB Rossi, P le Scuro 10, 37134 Verona, Italy
    Toxicol Lett 185:9-15. 2009
    Occupational exposure to styrene was studied in 34 workers employed in the production of fiberglass-reinforced plastic sheets and compared to 29 unexposed healthy controls...
  17. ncbi Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industry
    E Delzell
    Department of Epidemiology and International Health, University of Alabama at Birmingham School of Public Health, 517 Ryals Building, 1665 University Blvd, Birmingham, AL 35294, USA
    Chem Biol Interact 135:515-34. 2001
    This study evaluated relations between exposure to 1,3-butadiene (BD), styrene (STY) and dimethyldithiocarbamate (DMDTC) and mortality from leukemia among synthetic rubber industry workers...
  18. ncbi Estimation of a possible tumorigenic risk of styrene from daily intake via food and ambient air
    Johannes G Filser
    GSF Institute of Toxicology, Ingolstaedter Landstrasse 1, D 85764, Neuherberg, Germany
    Toxicol Lett 126:1-18. 2002
    Concerns of a tumorigenic risk of styrene (ST) originate from the findings that styrene (ST) is metabolized to the genotoxic intermediate styrene-7,8-oxide (SO)...
  19. ncbi Electrospun mats from styrene/maleic anhydride copolymers: modification with amines and assessment of antimicrobial activity
    Milena Ignatova
    Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad G Bonchev Bl 103A, 1113 Sofia, Bulgaria
    Macromol Biosci 10:944-54. 2010
    New antimicrobial microfibrous electrospun mats from styrene/maleic anhydride copolymers were prepared...
  20. ncbi Low level occupational exposure to styrene: its effects on DNA damage and DNA repair
    Sirilak Wongvijitsuk
    Laboratory of Environmental Toxicology, Chulabhorn Research Institute, Bangkok 10210, Thailand
    Int J Hyg Environ Health 214:127-37. 2011
    The present study aimed to evaluate the effects of styrene exposure at levels below the recommended standards of the Threshold Limit Value (TLV-TWA(8)) of 20 ppm (ACGIH, 2004) in reinforced-fiberglass plastics workers...
  21. ncbi Cancer mortality of workers exposed to styrene in the U.S. Reinforced plastics and composite industry
    James J Collins
    Dow Chemical Company, Midland, MI 48674, USA
    Epidemiology 24:195-203. 2013
    Epidemiologic studies have reported increased risk of lymphohematopoietic cancers, lung cancer, and pancreatic cancer after exposure to styrene, although findings across studies are not consistent.
  22. pmc Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component flavin-diffusible monooxygenase
    Katja Otto
    Institute of Biotechnology, ETHZ, Swiss Federal Institute of Technology, ETH Hoenggerberg, HPT, CH 8093, Zurich, Switzerland
    J Bacteriol 186:5292-302. 2004
    Pseudomonas sp. VLB120 uses styrene as a sole source of carbon and energy. The first step in this metabolic pathway is catalyzed by an oxygenase (StyA) and a NADH-flavin oxidoreductase (StyB)...
  23. ncbi Determination of urinary styrene metabolites in the general Italian population by liquid chromatography-tandem mass spectrometry
    Paola Manini
    Laboratory of Industrial Toxicology, Department of Clinical Medicine, Nephrology and Health Sciences, University of Parma, Via Gramsci 14, 43100 Parma, Italy
    Int Arch Occup Environ Health 77:433-6. 2004
    To apply mass spectrometry-based techniques for the determination of background levels of metabolites of widespread organic solvents, such as styrene, in unexposed subjects from the general population.
  24. ncbi Multistate reactivity in styrene epoxidation by compound I of cytochrome p450: mechanisms of products and side products formation
    Devesh Kumar
    Department of Organic Chemistry and the Lise Meitner Minerva Center for Computational Quantum Chemistry, The Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Chemistry 11:2825-35. 2005
    Density functional theoretical calculations are used to elucidate the epoxidation mechanism of styrene with a cytochrome P450 model Compound I, and the formation of side products...
  25. ncbi Styrene removal from polluted air in one and two-liquid phase biotrickling filter: steady and transient-state performance and pressure drop control
    Eldon R Rene
    Chemical Engineering Laboratory, Faculty of Sciences, University of La Coruna, Rúa da Fraga, 10, E 15008 La Coruña, Spain
    Bioresour Technol 102:6791-800. 2011
    A Sporothrix variecibatus-inoculated biotrickling filter (BTF) was examined for styrene removal, without and with the addition of silicone oil, at different empty bed residence times. The highest elimination capacities (ECs) were 172...
  26. ncbi Control of the stereo-selectivity of styrene epoxidation by cytochrome P450 BM3 using structure-based mutagenesis
    Wei Cheng Huang
    Henry Wellcome Laboratories of Structural Biology, Department of Biochemistry, University of Leicester, Henry, Wellcome Building, PO Box 138, Lancaster Road, Leicester LE1 9HN, United Kingdom
    Metallomics 3:410-6. 2011
    ..J. Mol. Biol., 2007, 373, 633) and styrene. In this paper, additional mutations at Thr438 are shown to decrease the binding of and catalytic activity ..
  27. ncbi Mechanism of flavin transfer and oxygen activation by the two-component flavoenzyme styrene monooxygenase
    Auric Kantz
    Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, CA 94132 4163, USA
    Arch Biochem Biophys 442:102-16. 2005
    b>Styrene monooxygenase (SMO) from Pseudomonas putida S12 is a two-component flavoenzyme composed of the NADH-specific flavin reductase, SMOB, and FAD-specific styrene epoxidase, SMOA...
  28. ncbi Less is more: reduced catechol production permits Pseudomonas putida F1 to grow on styrene
    Kevin W George
    Field of Environmental Toxicology, Cornell University, Ithaca, NY 14850, USA
    Microbiology 158:2781-8. 2012
    Pseudomonas putida F1 is unable to grow on styrene due to the accumulation of 3-vinylcatechol, a toxic metabolite that is produced through the toluene degradation (tod) pathway and causes catechol-2,3-dioxygenase (C23O) inactivation...
  29. ncbi Hepatotoxicity and pneumotoxicity of styrene and its metabolites in glutathione S-transferase-deficient mice
    Gary P Carlson
    School of Health Sciences, Purdue University, West Lafayette, Indiana 47907 2051, USA
    Drug Chem Toxicol 34:440-4. 2011
    b>Styrene is known to be hepatotoxic and pneumotoxic in rodents, and these adverse effects are related to its metabolism...
  30. ncbi Simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene using high-performance liquid chromatography/hybrid quadrupole time-of-flight mass spectrometry
    Stefano Marchese
    Dipartimento di Chimica, Universita La Sapienza di Roma, Piazzale Aldo Moro n degrees 5, PO Box 34, Posta 62, 00185 Rome, Italy
    Rapid Commun Mass Spectrom 18:265-72. 2004
    ..LC/MS/MS) for the simultaneous determination of the urinary metabolites of benzene, toluene, xylene and styrene in human urine specimens and standard solutions is described...
  31. ncbi Critical appraisal of the expression of cytochrome P450 enzymes in human lung and evaluation of the possibility that such expression provides evidence of potential styrene tumorigenicity in humans
    Gary P Carlson
    School of Health Sciences, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, United States
    Toxicology 254:1-10. 2008
    b>Styrene is widely used with significant human exposure, particularly in the reinforced plastics industry...
  32. ncbi Impairments of colour vision induced by organic solvents: a meta-analysis study
    Galina V Paramei
    Institute of Medical Psychology, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Neurotoxicology 25:803-16. 2004
    The impairment of colour discrimination induced by occupational exposure to toluene, styrene and mixtures of organic solvents is reviewed and analysed using a meta-analytical approach...
  33. ncbi Heterogeneity in styrene-butadiene latex films
    Juliane P Santos
    Institute of Chemistry, Universidade Estadual de Campinas, P O Box 6154, 13083 970 Campinas SP, Brazil
    Langmuir 20:10576-82. 2004
    Low-Tg styrene-butadiene (SB) latex films were investigated by noncontact atomic force microscopy and scanning electric potential microscopy, revealing a number of different morphologies and electric potential patterns across films cast ..
  34. ncbi Styrene induces an inflammatory response in human lung epithelial cells via oxidative stress and NF-kappaB activation
    Carmen Röder-Stolinski
    UFZ Helmholtz Centre for Environmental Research, Department of Environmental Immunology, Permoserstrasse 15, D 04318 Leipzig, Germany
    Toxicol Appl Pharmacol 231:241-7. 2008
    b>Styrene is a volatile organic compound (VOC) that is widely used as a solvent in many industrial settings. Chronic exposure to styrene can result in irritation of the mucosa of the upper respiratory tract...
  35. ncbi Styrene maleic acid-pirarubicin disrupts tumor microcirculation and enhances the permeability of colorectal liver metastases
    Jurstine Daruwalla
    Department of Surgery, University of Melbourne, Austin Hospital, Studley Road, Heidelberg, Victoria 3084, Australia
    J Vasc Res 46:218-28. 2009
    ..Pirarubicin, derived from doxorubicin, selectively targets tumors when encapsulated in styrene maleic acid (SMA), forming the macromolecular SMA pirarubicin...
  36. ncbi Disposition of styrene-acrylonitrile (SAN) trimer in female rats: single dose intravenous and gavage studies
    Michael L Gargas
    The Sapphire Group, Dayton, OH 45431, USA
    Toxicol Lett 178:1-8. 2008
    b>Styrene-acrylonitrile trimer (SAN Trimer), a mixture of six isomers (four isomers of 4-cyano-1,2,3,4-tetrahydro-alpha-methyl-1-naphthaleneacetonitrile [THAN] and two isomers of 4-cyano-1,2,3,4-tetrahydro-1-naphthaleneproprionitrile [THNP]..
  37. ncbi Leaching of styrene and other aromatic compounds in drinking water from PS bottles
    Maqbool Ahmad
    Environmental Control Department, Directorate General for Royal Commission at Yanbu, P O Box 30031 Yanbu Al Sinaiyah, Kingdom of Saudi Arabia
    J Environ Sci (China) 19:421-6. 2007
    Bottled water may not be safer, or healthier, than tap water. The present studies have proved that styrene and some other aromatic compounds leach continuously from polystyrene (PS) bottles used locally for packaging...
  38. ncbi Production in food of 1,3-pentadiene and styrene by Trichoderma species
    S E Pinches
    Biosciences, Council for Scientific and Industrial Research CSIR, PO Box 395, Pretoria 0001, South Africa
    Int J Food Microbiol 116:182-5. 2007
    ..of two strains of Trichoderma, isolated from food, to produce the Volatile Organic Compounds 1,3-pentadiene and styrene was investigated...
  39. ncbi Metabolism of phenylalanine and biosynthesis of styrene in Penicillium camemberti
    Yves Pagot
    UMR de Microbiologie et Génétique Moléculaire, Institut National Agronomique Paris Grignon, UMR INRA 537, URA CNRS 1925, F 78850 Thiverval Grignon France
    J Dairy Res 74:180-5. 2007
    The occurrence of styrene in food may be an important aroma defect (celluloid odour), even at very low concentrations (Miltz et al. 1980) causing consumer rejection and is therefore a problem for the food industry...
  40. ncbi Effects of styrene and styrene oxide on glutathione-related antioxidant enzymes
    Gary P Carlson
    School of Health Sciences, Purdue University, West Lafayette, IN 47907, USA
    Toxicology 227:217-26. 2006
    b>Styrene is both hepatotoxic and pneumotoxic in mice. Its mode of action is not clear, but it may be related to oxidative stress including a very large decrease in reduced glutathione (GSH)...
  41. ncbi Strain of Fusarium oxysporum isolated from almond hulls produces styrene and 7-methyl-1,3,5-cyclooctatriene as the principal volatile components
    John J Beck
    Western Regional Research Center, U S Department of Agriculture, Albany, California 94710, USA
    J Agric Food Chem 56:11392-8. 2008
    ..the hulls of Prunus dulcis (sweet almond) was found to produce relatively large quantities of the hydrocarbons styrene and two isomers of 7-methyl-1,3,5- cyclooctatriene (MCOT)...
  42. ncbi Analysis of acrylonitrile, 1,3-butadiene, and related compounds in acrylonitrile-butadiene-styrene copolymers for kitchen utensils and children's toys by headspace gas chromatography/mass spectrometry
    Hiroyuki Ohno
    Nagoya City Public Health Research Institute, Environmental Health Department, 1 11, Hagiyama cho, Mizuho ku, Nagoya 467 8615, Japan
    J AOAC Int 93:1965-71. 2010
    ..their related compounds containing propionitrile (PN) and 4-vinyl-1-cyclohexene (4-VC) in acrylonitrile-butadiene-styrene (ABS) copolymers for kitchen utensils and children's toys...
  43. ncbi Removal of styrene vapor from waste gases by a trickle-bed air biofilter
    C Lu
    Department of Environmental Engineering, National Chung Hsing University, Taichung 402, Taiwan ROC
    J Hazard Mater 82:233-45. 2001
    The trickle-bed air biofilter (TBAB) performance for the removal of high-strength styrene was evaluated under different gas flow rates and influent concentrations...
  44. ncbi Biodegradation of gaseous styrene by Brevibacillus sp. using a novel agitating biotrickling filter
    Jae Woong Hwang
    Technical Consulting Team, Environmental Management Corporation, Incheon, 404 708, Korea
    Biotechnol Lett 30:1207-12. 2008
    ..biomass accumulation, the agitating biotrickling filter (ABTF) system, was developed for treatment of gaseous styrene using Brevibacillus sp...
  45. ncbi Indicators of oxidative stress and apoptosis in mouse whole lung and Clara cells following exposure to styrene and its metabolites
    Jill A Harvilchuck
    School of Health Sciences, Purdue University, West Lafayette, IN 47907 2051, USA
    Toxicology 264:171-8. 2009
    In mice, styrene is hepatotoxic, pneumotoxic, and causes lung tumors. One explanation for the mechanism of toxicity is oxidative stress/damage...
  46. ncbi Relationship between the capacity to repair 8-oxoguanine, biomarkers of genotoxicity and individual susceptibility in styrene-exposed workers
    J Slyskova
    Department of Experimental and Applied Genetics, Research Base of Slovak Medical University, Bratislava, Slovak Republic
    Mutat Res 634:101-11. 2007
    Genotoxic effects related to exposure to styrene have been a matter of investigation for many years by employing markers of exposure, effect and susceptibility...
  47. ncbi Determination of volatile organic compounds in biological samples using headspace solid-phase microextraction and gas chromatography: toluene and styrene
    Radhika Barua
    Department of Clinical and Laboratory Sciences, SUNY at Buffalo, Buffalo, New York, USA
    J Anal Toxicol 32:379-86. 2008
    Epidemiological and laboratory investigations have shown that toluene and styrene are toxic compounds that lead to impairment of the nervous system...
  48. ncbi Guidance of neurite outgrowth on aligned electrospun polypyrrole/poly(styrene-beta-isobutylene-beta-styrene) fiber platforms
    Xiao Liu
    ARC Centre of Excellence for Electromaterials Science, University of Wollongong, Wollongong NSW, Australia
    J Biomed Mater Res A 94:1004-11. 2010
    ..work was to investigate the potential biomedical application of novel aligned electrospun polypyrrole (PPy)/poly(styrene-beta-isobutylene-beta-styrene) (SIBS) fibers...
  49. ncbi Kinetics of styrene biodegradation in synthetic wastewaters using an industrial activated sludge
    R Babaee
    Chemical Engineering Department, Amirkabir University of Technology, 424 Hafez Ave, Tehran, Iran
    J Hazard Mater 184:111-7. 2010
    Kinetics of styrene biodegradation in synthetic wastewaters, containing either styrene or styrene together with ethanol, by an industrial activated sludge obtained from the wastewater treatment unit of a petrochemical complex was studied...
  50. ncbi Induction heating for surface triggering styrene polymerization on titanium modified with ATRP initiator
    Bastien Barthélémy
    Laboratory of Chemistry and Electrochemistry of Surfaces CES, University of Namur FUNDP, rue de Bruxelles, 61, B 5000 Namur, Belgium
    J Colloid Interface Sci 354:873-9. 2011
    ..The present work aims to study the surface-initiated ATR polymerization of styrene on titanium substrates, using grafted 11-(2-bromoisobutyrate)-undecyl-1-phosphonic acid as initiator and to ..
  51. pmc Identification of a novel self-sufficient styrene monooxygenase from Rhodococcus opacus 1CP
    Dirk Tischler
    Environmental Microbiology, TU Bergakademie Freiberg, Freiberg, Germany
    J Bacteriol 191:4996-5009. 2009
    ..to identification of an open reading frame encoding a novel fusion protein, StyA2B, with a putative function in styrene metabolism via styrene oxide and phenylacetic acid...
  52. ncbi Bacterial degradation of styrene in waste gases using a peat filter
    M Arnold
    VTT Chemical Technology, Finland
    Appl Microbiol Biotechnol 48:738-44. 1997
    A biofiltration process was developed for styrene-containing off-gases using peat as filter material. The average styrene reduction ratio after 190 days of operation was 70% (max...
  53. ncbi CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors
    G Cruzan
    ToxWorks, 1153 Roadstown Road, Bridgeton, NJ, USA
    Regul Toxicol Pharmacol 62:214-20. 2012
    b>Styrene induces lung tumors in mice but not in rats. Although metabolism of styrene to 7,8-styrene oxide (SO) by CYP2E1 has been suggested as a mediator of styrene toxicity, lung toxicity is not attenuated in CYP2E1 knockout mice...
  54. ncbi Styrene degradation by Pseudomonas sp. SR-5 in biofilters with organic and inorganic packing materials
    J H Jang
    Chemical Resources Laboratory, Tokyo Institute of Technology, 4259 Nagatsuta, Midori ku, Yokohama, 226 8503, Japan
    Appl Microbiol Biotechnol 65:349-55. 2004
    Pseudomonas sp. SR-5 was isolated as a styrene-degrading bacterium. In liquid culture containing 1% (v/v) styrene, more than 90% styrene was degraded in 53 h and the doubling time of SR-5 was 2 h...
  55. ncbi Chronic toxicity/oncogenicity study of styrene in CD-1 mice by inhalation exposure for 104 weeks
    G Cruzan
    ToxWorks, 1153 Roadstown Rd, Bridgeton, NJ 08302, USA
    J Appl Toxicol 21:185-98. 2001
    Groups of 70 male and 70 female Charles River CD-1 mice were exposed whole body to styrene vapor at 0, 20, 40, 80 or 160 ppm 6 h per day 5 days per week for 98 weeks (females) or 104 weeks (males)...
  56. ncbi Response of human cord blood cells to styrene exposure: evaluation of its effects on apoptosis and gene expression by genomic technology
    Cristina Diodovich
    Laboratory of Hematotoxicology, ECVAM Institute for Health and Consumer Protection, JRC, Ispra, Italy
    Toxicology 200:145-57. 2004
    b>Styrene is one of the most important monomers produced worldwide, and it finds major use in the production of polystyrene, acrylonitrile-butadiene-styrene resins and unsaturated polystyrene resins...
  57. ncbi Immobilization of lipase B from Candida antarctica on porous styrene-divinylbenzene beads improves butyl acetate synthesis
    Natália G Graebin
    Biocatalysis and Enzyme Technology Lab, Institute of Food Science and Technology, Federal University of Rio Grande do Sul State, Av Bento Goncalves, ZC 91501 970, Porto Alegre, RS, Brazil
    Biotechnol Prog 28:406-12. 2012
    A new biocatalyst of lipase B from Candida antarctica (MCI-CALB) immobilized on styrene-divinylbenzene beads (MCI GEL CHP20P) was compared with the commercial Novozym 435 (immobilized lipase) in terms of their performances as ..
  58. ncbi Biodegradation of gas-phase styrene using the fungus Sporothrix variecibatus: impact of pollutant load and transient operation
    Eldon R Rene
    Chemical Engineering Laboratory, Faculty of Sciences, University of La Coruna, Rua Alejandro de la Sota, 1, E 15008 La Coruña, Spain
    Chemosphere 79:221-7. 2010
    Biofiltration of gas-phase styrene was studied using a newly isolated fungus Sporothrix variecibatus, in a perlite biofilter, at inlet concentrations and gas-flow rates ranging from 0.13 to 14 g m(-3) and 0.075 to 0...
  59. pmc Role of metabolic activation and the TRPA1 receptor in the sensory irritation response to styrene and naphthalene
    Michael J Lanosa
    Toxicology Program, Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA
    Toxicol Sci 115:589-95. 2010
    ..transient receptor potential ankyrin 1 receptor (TRPA1) in mediating the sensory irritation response to styrene and naphthalene...
  60. pmc Human neurobehavioral effects of long-term exposure to styrene: a meta-analysis
    Vernon A Benignus
    Human Studies Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 113:532-8. 2005
    Many reports in the literature suggest that long-term exposure to styrene may exert a variety of effects on the nervous system, including increased choice reaction time and decreased performance of color discrimination and color ..
  61. ncbi Analysis of the Pseudomonas putida CA-3 proteome during growth on styrene under nitrogen-limiting and non-limiting conditions
    Jasmina Nikodinovic-Runic
    School of Biomolecular and Biomedical Science, Centre for Synthesis and Chemical Biology, University College Dublin, Belfield, Dublin, Ireland
    Microbiology 155:3348-61. 2009
    Pseudomonas putida CA-3 is a styrene-degrading bacterium capable of accumulating medium-chain-length polyhydroxyalkanoate (mclPHA) when exposed to limiting concentrations of a nitrogen source in the growth medium...
  62. ncbi Cumulative exposure to styrene and visual functions
    L Castillo
    , , , , Canada
    Am J Ind Med 39:351-60. 2001
    ..from a 1990-1992 longitudinal study of several reinforced plastics plants showed that for those workers whose styrene exposure had decreased, color vision (CV) improved; while near visual contrast sensitivity (CS) was poorer...
  63. ncbi Styrene biosynthesis from glucose by engineered E. coli
    Rebekah McKenna
    Chemical Engineering, Arizona State University, 501 E Tyler Mall, Tempe, AZ 85287 6106, USA
    Metab Eng 13:544-54. 2011
    b>Styrene is a large volume, commodity petrochemical with diverse commercial applications, including as a monomer building-block for the synthesis of many useful polymers...
  64. ncbi Syntheses, characterization and study of the use of cobalt (II) Schiff-base complexes as catalysts for the oxidation of styrene by molecular oxygen
    Ali Akbar Khandar
    Department of Inorganic Chemistry, Faculty of Chemistry, Tabriz University, Tabriz, Iran
    Molecules 10:302-11. 2005
    ..These complexes catalyze the oxidation of styrene in the presence of dioxygen and excess pyridine...
  65. ncbi Thyroid function and exposure to styrene
    Ferruccio Santini
    Department of Endocrinology and Kidney, University Hospital of Pisa, Pisa, Italy
    Thyroid 18:1065-9. 2008
    ..The aim of this study was to evaluate the effects of styrene on the thyroid axis in occupationally exposed workers.
  66. pmc Genetic and functional analysis of the styrene catabolic cluster of Pseudomonas sp. strain Y2
    A Velasco
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas, CSIC, Madrid, Spain
    J Bacteriol 180:1063-71. 1998
    The chromosomal region of Pseudomonas sp. strain Y2 involved in the conversion of styrene to phenylacetate (upper catabolic pathway) has been cloned and sequenced...
  67. ncbi Shape-dependent catalytic activity of silver nanoparticles for the oxidation of styrene
    Run Xu
    Department of Chemistry, Tsinghua University, Beijing, 100084, PR China
    Chem Asian J 1:888-93. 2006
    ..silver nanoparticles was compared with that of cubic and near-spherical silver nanoparticles in the oxidation of styrene in colloidal solution...
  68. ncbi Exposure to styrene in fiberglass-reinforced plastic manufacture: still a problem
    Bruno Papaleo
    INAIL, ex ISPESL Department of Occupational Medicine, Monte Porzio Catone, Italy
    J Occup Environ Med 53:1273-8. 2011
    The aim of the work is to define occupational exposure to styrene in fiberglass manufacture; the phase of stretching styrene resins needs some manual handling and leads workers to be exposed to styrene.
  69. pmc Proteome changes in human bronchoalveolar cells following styrene exposure indicate involvement of oxidative stress in the molecular-response mechanism
    Nora Mörbt
    Department of Proteomics, UFZ, Helmholtz Centre for Environmental Research, Leipzig, Germany
    Proteomics 9:4920-33. 2009
    b>Styrene is a volatile organic compound that is widely used as an intermediate in many industrial settings...
  70. ncbi Ototoxicity of toluene and styrene: state of current knowledge
    Perrine Hoet
    Industrial Toxicology Unit, Faculty of Medicine, Universite Catholique de Louvain, Brussels, Belgium
    Crit Rev Toxicol 38:127-70. 2008
    ..The main objective of this review was to analyze the available scientific literature on the ototoxic effects of styrene and toluene, in order to examine dose-response/effect relationships and the relevance of the prevention strategy ..
  71. ncbi Cochlear injuries induced by the combined exposure to noise and styrene
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, 137 Cary Hall, 3435 Main Street, Buffalo, NY 14214, USA
    Hear Res 254:25-33. 2009
    ..A noise band of 10-20 kHz was used to induce a cochlear injury in the same cochlear region in the rat as styrene exposure...
  72. ncbi Characteristics of styrene degradation by Rhodococcus pyridinovorans isolated from a biofilter
    In Gyung Jung
    Industrial Liaison Research Institute, Kyung Hee University, Yongin 449 701, South Korea
    Chemosphere 61:451-6. 2005
    A novel strain (PYJ-1) of Rhodococcus pyridinovorans that was isolated from a biofilter was able to degrade styrene at a maximum rate of 0.16 mg (mg protein)(-1) h(-1) in batch culture at 97 mg l(-1) of initial styrene gas concentration...
  73. ncbi Performance of a styrene-degrading biofilter inoculated with Pseudomonas sp. SR-5
    Jong Hee Jang
    Chemical Resources Laboratory, Tokyo Institute of Technology, R1 29 4259 Nagatsuta, Midori ku, Yokohama 226 8503, Japan
    J Biosci Bioeng 100:297-302. 2005
    b>Styrene removal was studied for 3 months in a laboratory-scale biofilter packed with a mixed packing material of peat and ceramic at a ratio of 1 to 1 on a dry-weight basis and inoculated with Pseudomonas sp. SR-5...
  74. ncbi Effects of subchronic exposure to styrene on the extracellular and tissue levels of dopamine, serotonin and their metabolites in rat brain
    F Gagnaire
    Département Polluants et Santé, Institut National de Recherche et de Securite, Avenue de Bourgogne, BP 27, 54501, Vandoeuvre Cedex, France
    Arch Toxicol 80:703-12. 2006
    At present, there is controversy over the neurotoxic potential of styrene. Several epidemiological and clinical studies have shown that styrene exposure causes alterations of central nervous system functions in humans...
  75. ncbi Styrene lower catabolic pathway in Pseudomonas fluorescens ST: identification and characterization of genes for phenylacetic acid degradation
    Patrizia Di Gennaro
    Department of Environmental Sciences, University of Milano Bicocca, Piazza della Scienza 1, 20126, Milan, Italy
    Arch Microbiol 188:117-25. 2007
    Pseudomonas fluorescens ST is a styrene degrading microorganism that, by the sequential oxidation of the vinyl side chain, converts styrene to phenylacetic acid...
  76. ncbi Audiological findings in workers exposed to styrene alone or in concert with noise
    Ann Christin Johnson
    Karolinska Institutet, Section of Audiology, Department of Clinical Science, Intervention and Technique, Alfred Nobels Alle 10, S 141 83 Stockholm, Sweden
    Noise Health 8:45-57. 2006
    Audiological testing, interviews and exposure measurements were used to collect data on the health effects of styrene exposures in 313 workers from fiberglass and metal-product manufacturing plants and a mail terminal...
  77. ncbi Styrene-catabolism regulation in Pseudomonas fluorescens ST: phosphorylation of StyR induces dimerization and cooperative DNA-binding
    Livia Leoni
    Dipartimento di Biologia, Universita Roma Tre, Viale G Marconi 446, I 00146 Rome, Italy
    Biochem Biophys Res Commun 303:926-31. 2003
    b>Styrene is an important chemical extensively used in the petrochemical and polymer industries...
  78. ncbi Occupational styrene exposure and neurobehavioural functions: a cohort study with repeated measurements
    Andreas Seeber
    Institute of Occupational Physiology at the University of Dortmund, Dortmund, Germany
    Int Arch Occup Environ Health 82:969-84. 2009
    Associations between occupational styrene exposure and cognitive as well as psychomotor functions were investigated with a view to answering three questions: (1) are the published results for neurobehavioural impairment reproducible, (2) ..
  79. ncbi Temporal processing disorder associated with styrene exposure
    Ewa Zamyslowska-Szmytke
    Department of Audiology and Phoniatrics, Nofer Institute of Occupational Medicine, PL 91 348 Łódź, Poland
    Audiol Neurootol 14:296-302. 2009
    Little evidence exists on the possible adverse effects of styrene on the central part of the auditory system. The present investigation aimed to study the possible association between styrene exposure and temporal processing abilities...
  80. ncbi Transcriptional regulation of styrene degradation in Pseudomonas putida CA-3
    W Duetz
    Microbiology Department, National University of Ireland, Cork, Ireland
    Microbiology 147:973-9. 2001
    The styrene degradative pathway in Pseudmonas putida CA-3 has previously been shown to be divided into an upper pathway involving the conversion of styrene to phenylacetic acid and a lower pathway for the subsequent degradation of ..
  81. ncbi Audiometric findings in workers exposed to low levels of styrene and noise
    Thais C Morata
    National Institute for Occupational Safety and Health, Division of Applied Research and Technology, Cincinnati, Ohio 45226, USA
    J Occup Environ Med 44:806-14. 2002
    ..Workers exposed to noise and styrene had significantly worse pure-tone thresholds at 2, 3, 4, and 6 kHz when compared with noise-exposed or nonexposed ..
  82. ncbi Effect of multiple doses of styrene and R-styrene oxide on CC10, bax, and bcl-2 expression in isolated Clara cells of CD-1 mice
    Jill A Harvilchuck
    School of Health Sciences, Purdue University, Civil Engineering Building, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
    Toxicology 259:149-52. 2009
    b>Styrene exposure is highest among workers in the reinforced plastics industry with exposure seen for 5 consecutive days during the work week. Styrene is both hepatotoxic and pneumotoxic in mice, in addition to causing lung tumors...
  83. ncbi Relation between outer hair cell loss and hearing loss in rats exposed to styrene
    Guang Di Chen
    Center for Hearing and Deafness, SUNY at Buffalo, Buffalo, NY 14214, USA
    Hear Res 243:28-34. 2008
    ..b>Styrene is an ototoxic agent, which targets and destroys OHCs starting from the third row to the second and first rows ..
  84. ncbi Microbial degradation of styrene: biochemistry, molecular genetics, and perspectives for biotechnological applications
    Aisling Mooney
    Centre for Synthesis and Chemical Biology, School of Biomolecular and Biomedical Sciences, College of Life Sciences, University College Dublin, Belfield, Dublin 4, Ireland
    Appl Microbiol Biotechnol 72:1-10. 2006
    Large quantities of the potentially toxic compound styrene are produced and used annually by the petrochemical and polymer-processing industries...
  85. ncbi Occupational styrene exposure and hearing loss: a cohort study with repeated measurements
    Gerhard Triebig
    Institute and Outpatient Clinic for Occupational and Social Medicine, University Hospital of Heidelberg, Vossstrasse 2, Heidelberg, Germany
    Int Arch Occup Environ Health 82:463-80. 2009
    Associations between occupational styrene exposure and impairment of hearing function were investigated, guided by three questions: are there hearing losses concerning high frequency and standard audiometric test? Are there dose-response ..
  86. pmc Accumulation of polyhydroxyalkanoate from styrene and phenylacetic acid by Pseudomonas putida CA-3
    Patrick G Ward
    Department of Industrial Microbiology, Centre for Synthesis and Chemical Biology, Conway Institute for Biomolecular and Biomedical Research, National University of Ireland, University College Dublin, Belfield, Dublin 4, Republic of Ireland
    Appl Environ Microbiol 71:2046-52. 2005
    Pseudomonas putida CA-3 is capable of converting the aromatic hydrocarbon styrene, its metabolite phenylacetic acid, and glucose into polyhydroxyalkanoate (PHA) when a limiting concentration of nitrogen (as sodium ammonium phosphate) is ..
  87. ncbi Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an update
    Avima M Ruder
    The National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Am J Ind Med 45:165-76. 2004
    Mortality was updated through 1998 for 5,204 workers exposed to styrene between 1959 and 1978 at two reinforced plastic boatbuilding plants. The a priori hypothesis: leukemia and lymphoma excesses would be found.
  88. ncbi Occupational exposure to styrene: modulation of cytogenetic damage and levels of urinary metabolites of styrene by polymorphisms in genes CYP2E1, EPHX1, GSTM1, GSTT1 and GSTP1
    João P Teixeira
    National Institute of Health, Environmental Health and Toxicology Department, Largo 1 de Dezembro, 4000 Porto, Portugal
    Toxicology 195:231-42. 2004
    b>Styrene is widely used in the production of various plastics, synthetic rubber and resins...
  89. ncbi Historical estimation of exposure to 1,3-butadiene, styrene, and dimethyldithiocarbamate among synthetic rubber workers
    Maurizio Macaluso
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham, AL, USA
    J Occup Environ Hyg 1:371-90. 2004
    Quantitative estimates of exposure to 1,3-butadiene (BD), styrene (STY), and dimethyldithiocarbamate (DMDTC) were developed for a follow-up study of workers at six North American synthetic rubber plants...
  90. ncbi Influence of genetic polymorphisms on biomarkers of exposure and genotoxic effects in styrene-exposed workers
    Lode Godderis
    Katholieke Universiteit Leuven, Laboratorium Voor Arbeidshygiëne en Toxicologie, 3000 Leuven, Belgium
    Environ Mol Mutagen 44:293-303. 2004
    A study on 44 workers exposed to styrene and 44 matched referents was performed in order to examine the influence of genetic polymorphisms in biotransformation and DNA repair enzymes on the levels of N-terminal hemoglobin adducts and ..
  91. pmc Dual role of response regulator StyR in styrene catabolism regulation
    Livia Leoni
    Department of Biology, University Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Appl Environ Microbiol 71:5411-9. 2005
    In Pseudomonas fluorescens ST, the promoter of the styrene catabolic operon, PstyA, is induced by styrene and repressed by the addition of preferred carbon sources. PstyA is regulated by the StyS/StyR two-component system...
  92. ncbi Occupational exposure to vinyl chloride, acrylonitrile and styrene and lung cancer risk (europe)
    Ghislaine Scelo
    International Agency for Research on Cancer, Lyon 69008, France
    Cancer Causes Control 15:445-52. 2004
    ..cohort studies have addressed the risk of lung cancer following exposure to vinyl chloride, acrylonitrile and styrene, with inconsistent results and usually without smoking adjustment...
  93. pmc Coregulation by phenylacetyl-coenzyme A-responsive PaaX integrates control of the upper and lower pathways for catabolism of styrene by Pseudomonas sp. strain Y2
    Teresa del Peso-Santos
    Department of Biochemistry and Molecular Biology, I, Facultad de Ciencias Biologicas, Universidad Complutense, 28040 Madrid, Spain
    J Bacteriol 188:4812-21. 2006
    ..strain Y2 controls expression of the styABCD genes, which are required for the conversion of styrene to phenylacetate, which is further catabolized by the products of two paa gene clusters...
  94. pmc Genetic characterization of accumulation of polyhydroxyalkanoate from styrene in Pseudomonas putida CA-3
    Niall D O'Leary
    Microbiology Department, National University of Ireland, Cork, Ireland
    Appl Environ Microbiol 71:4380-7. 2005
    ..capable of accumulating medium-chain-length polyhydroxyalkanoates (MCL-PHAs) when growing on the toxic pollutant styrene as the sole source of carbon and energy...
  95. ncbi Migration of styrene monomer, dimers and trimers from polystyrene to food simulants
    Jin Ok Choi
    Kyungnam University, Division of Food Science and Biotechnology, Korea
    Food Addit Contam 22:693-9. 2005
    ..04 and 10.05 dm2 l(-1) for n-heptane and distilled water, respectively. Styrene monomer, styrene dimers and styrene trimers migrating to the food simulants were determined by GC-FID analysis...
  96. ncbi Preclinical evaluation for noninvasive reversal following long-term vas occlusion with styrene maleic anhydride in langur monkeys
    Nirmal K Lohiya
    Reproductive Physiology Section, Department of Zoology, University of Rajasthan, Jaipur 302 004, India
    Contraception 71:214-26. 2005
    A preclinical evaluation for reversal through a noninvasive approach following long-term vas occlusion with styrene maleic anhydride (SMA) has been attempted in langur monkeys at the level of semen parameters, sperm functional tests, ..
  97. ncbi Leukemia and cumulative exposure to butadiene, styrene and benzene among workers in the synthetic rubber industry
    M Macaluso
    Department of Epidemiology, School of Public Health, University of Alabama at Birmingham 35294 2170, USA
    Toxicology 113:190-202. 1996
    Retrospective, quantitative estimates of exposure to 1,3-butadiene, styrene and benzene were developed for a follow-up study of leukemia mortality among 16610 subjects employed at six North American styrene-butadiene rubber manufacturing ..
  98. ncbi Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styrene
    Alessio Naccarati
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 537:131-40. 2003
    Occupational exposure to styrene, a chemical extensively used worldwide, is under investigation for possible detrimental effects on human health, including male reproductive capacity...
  99. ncbi An investigation of factors contributing to styrene and styrene-7,8-oxide exposures in the reinforced-plastics industry
    L A Nylander-French
    Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill 27599 7400, USA
    Ann Occup Hyg 43:99-105. 1999
    During the manufacturing of reinforced plastics, large amounts of styrene and trace quantities of styrene-7,8-oxide (SO) are released...
  100. ncbi Influence of GSTM1 and GSTT1 genotypes on sister chromatid exchange induction by styrene in cultured human lymphocytes
    Sabrina Bernardini
    Laboratory of Molecular and Cellular Toxicology, Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Topeliuksenkatu 41 a A, FIN 00250 Helsinki, Finland
    Carcinogenesis 23:893-7. 2002
    ..null genotype was associated with increased induction of sister chromatid exchanges (SCEs) by a metabolite of styrene, styrene-7,8-oxide, in human lymphocyte cultures, while GSTM1 genotype had no effect...
  101. ncbi The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications
    J M Luengo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Veterinaria, Universidad de Leon, 24007 Leon, Spain
    Mol Microbiol 39:1434-42. 2001
    ..The phenylacetyl-CoA catabolon encompasses all the routes involved in the transformation of styrene, 2-phenylethylamine, trans-styrylacetic acid, phenylacetaldehyde, phenylacetic acid, phenylacetyl amides, ..

Research Grants59

  1. ELECTROCATALYTIC STUDIES OF TOXIC POLLUTANT ACTIVATION
    James F Rusling; Fiscal Year: 2013
    ..Examples of bioactivated pollutants include styrene, benzo[a]pyrene, arylamines, and N-nitrosamines...
  2. CHEMISTRY SUPPORT SERVICES TO THE ENVIRONMENAL TOXICOLOGY PROGRAM
    Reshan Fernando; Fiscal Year: 2010
    ..In support of the carcinogenesis program, a low-level impurity screen was conducted on styrene acrylonitrile trimer looking for the presence of styrene and acrylonitrile mono- and dimers...
  3. Structure and Mechanisms of Styrene Monooxygenase
    George T Gassner; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Styrene is an important component of a wide array of plastic, rubber, and over the counter adhesive products...
  4. PLASMA PROTEINS: MARKERS OF CHEMICAL EXPOSURE
    GHULAM ANSARI; Fiscal Year: 1991
    ..such as aldehyde (acrolein, formaldehyde, and glutaraldehyde), epoxide (ethylene oxide, propylene oxide, and styrene oxide), and hydrocarbon (benzene, styrene, and butadiene) will be used as model compounds for this study...
  5. Studies of Chemical Disposition in Animals
    GLENN I SIPES; Fiscal Year: 2009
    ..TBBPA and TBBPA-DBPE are used as flame retardents in circuit boards and polycarbonate-acrylonitrile-butadiene-styrene plastics. There is widespread worker exposure to these chemicals and possible consumer exposure...
  6. Development of Extraocular Muscle Prosthesis for Paralytic Strabismus
    Yasushi Kato; Fiscal Year: 2009
    ..eye back to the primary position upon relaxation of the antagonist muscle;2) a novel biocompatible polymer, poly(styrene-block-isobutylene-block- styrene) or "SIBS," that does not elicit significant inflammatory reaction or ..
  7. RADIOPAQUE ADHESIVES AND DENTAL RESTORATIVE RESINS
    ISRAEL CABASSO; Fiscal Year: 2000
    ..To obtain reactive, radiopaque, adhesive resin components we wiU: optimize the yield of the bismuth-styrene derivatives, synthesize Sb-styrene monomers, synthesize the Bi, Ti, Zr, and Hf derivatives of vinylbenzyl ..
  8. Serum Inhibin B Levels in Male Polymer Production Worker
    Richard Lewis; Fiscal Year: 2000
    ..to lead and phthalate esters) and synthetic rubber production workers (exposed to acrylonitrile, butadiene, and styrene) will be analyzed for Inhibin B and FSH levels and compared with those from an age-matched control group (non-..
  9. Organic Solvent Mixtures & Neuropsychological Outcomes
    Ellen Kirrane; Fiscal Year: 2002
    ..known to be exposed to a variety of organic solvents including evaporative emissions from fuel and fuel exhaust, styrene and acetone during fiberglass work, paints and tars for waterproofing their traps...
  10. CASE CONTROL STUDY OF CANCER IN SYNTHETIC RUBBER WORKER
    Genevieve Matanoski; Fiscal Year: 1991
    ..lymphopoietic, hematologic, and gastrointestinal cancers and sarcomas from occupational exposure to butadiene and styrene and to determine if a dose response exists. Butadiene is the 36th most common chemical produced in the U.S...
  11. SELECTIVE REAL-TIME DETECTION OF OLEFIN GASES AND VAPORS
    EDWARD ZELLERS; Fiscal Year: 1991
    ..of each of the following olefin gases and vapors: acrylonitrile, butadiene, beta-chloroprene, ethylacrylate, styrene, vinyl chloride, and vinylidene chloride...
  12. PERIPHERAL MARKERS OF STYRENE TOXICITY
    Harvey Checkoway; Fiscal Year: 1990
    ..potential to a human population exposed occupationally to a known and quantifiable neurotoxic agent, styrene. The specific aims of this research are: 1) to compare levels of dopamine D2 receptors, monoamine oxidase type B ..
  13. FIBER OPTIC SENSORS BASED ON POLMER SWELLING
    RUDOLF SEITZ; Fiscal Year: 1999
    ..Hydrophilicity will be controlled by preparing copolymers of styrene and 2,4,5- trichlorophenylacrylate (TCPA) followed by conversion of the TCPA to a more hydrophilic functional ..
  14. ULTRASENSITIVE METHODS FOR HUMAN DNA ADDUCT QUANTITATION
    James Swenberg; Fiscal Year: 2000
    ..These adducts are formed in DNA from animals and humans exposed to vinyl chloride, simple alkylating agents and styrene oxide, and most can be demonstrated in DNA of unexposed animals and humans...
  15. Mechanistic studies of pulmonary toxicity of styrene
    Jiang Zheng; Fiscal Year: 2010
    Wide range effects of occupational styrene exposure have been reported to cause severe acute toxic effects. Inhaled styrene has been found to produce respiratory toxicity in human and animals...
  16. Dermatopharmacokinetics: In Vivo Analysis of Solvents
    Karla Thrall; Fiscal Year: 2005
    ..studies to evaluate the percutaneous absorption of compounds commonly encountered within similar industries (styrene and ethylbenzene) along with focused studies to evaluate the dermal bioavailability of compounds with both ..
  17. COLLABORATIVE STUDY OF 1,3 BUTADIENE BIOMARKERS
    Thomas Smith; Fiscal Year: 2002
    ..5-2 ppm full shift) during normal operations, and little concurrent exposure to styrene or acrylonitrite. Twenty tank cleaners will provide data on high exposure responses...
  18. Feto-Maternal Pharmacokinetics of Abused Inhalants
    STEPHEN DEWEY; Fiscal Year: 2004
    ..this fraction is 2% -4% for chlorinated hydrocarbons or for more highly substituted aromatics such as xylene and styrene. The proposed work builds on our previous extensive neuroimaging studies of drugs of abuse using positron ..
  19. Pd-Catalyzed Olefin Functionalization Reactions for Organic Synthesis
    MATTHEW SIGMAN; Fiscal Year: 2007
    ..of styrenes containing a phenol, (2) develop and investigate Pd-catalyzed hydroalkoxylation reactions of styrene derivatives, (3) explore Pd-catalyzed cross-coupling reactions utilizing organometallic reagents paired with an ..
  20. MECHANISMS OF HEPATOTOXICITY BY ENVIRONMENTAL POLLUTANTS
    Ronald Thurman; Fiscal Year: 1991
    ..gained in these studies will then be applied to other hepatotoxins including pesticides, vinyl chloride, styrene, benzene and toluene...
  21. RESPIRATORY TRACT IRRITANTS; MECHANISMS AND TOLERANCE
    Yves Alarie; Fiscal Year: 1980
    ..Benzoquinone, styrene, and styrene oxide will also be used...
  22. TOXICOKINETICS OF ETHYL TERTIARY-BUTYL ETHER
    Crispin Pierce; Fiscal Year: 1999
    ..physiologically-based toxicokinetic (PBTK) modeling approach developed previously uses stable isotope tracers for styrene, toluene and xylene exposures, administered to male volunteers via inhalation...
  23. DOSE/RESPONSE FOR STYRENE EXPOSURES
    Stephen Rappaport; Fiscal Year: 1992
    ..the linkages between exposure, absorbed dose, and cytogenetic response resulting from occupational exposures to styrene in the reinforced-plastics industry...
  24. BLOOD INTERACTIONS OF TRIBLOCK COPOLYMERS
    Joseph Andrade; Fiscal Year: 1980
    ..The styrene-butadiene-styrene (SBS) triblock copolymer series permits the control of micromorphology and, by selective ..
  25. EPOXIDE TOXICITY IN ALKENE METABOLISM
    JOSEPH SINSHEIMER; Fiscal Year: 1992
    ..Compounds of interest are (a) polycyclic aromatic alkyl epoxides; (b) styrene oxide derivatives (c) diol epoxides and (d) epoxides related to fecapentaene...
  26. Peptide-Modified Sulfonated Styrene Block Copolymers for Vascular Applications
    DAVID VACHON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  27. Functional Proteogenomics of Mitochondria
    Peter Oefner; Fiscal Year: 2005
    ..The concordance of protein data with those obtained by means of human mRNA expression arrays and the functional genomic findings from yeast will be assessed. ..
  28. CHIP BASED QTL MAPPING IN ARABIDOPSIS
    Peter Oefner; Fiscal Year: 2001
    ..It is anticipated that experience gained on the mapping of QTLs in Arabidopsis will be very valuable for similar efforts in other eukaryotes, including human. ..
  29. Development of MIDI-Ray Implant for Glaucoma
    Leonard Pinchuk; Fiscal Year: 2008
    ..pressure flow principle that limits flow and thereby prevents hypotony, 2) a novel biomaterial called poly(styrene-block-isobutylene-block-styrene) ( SIBS ) that does not form clinically significant scar tissue in the eye and 3) ..
  30. PRACTICAL CHEMICAL SYNTHESIS OF COMPLEX ALKALOIDS
    LARRY OVERMAN; Fiscal Year: 2009
    ....
  31. SCREENING PLATELETS INTERACTIONS WITH SURFACE GRADIENTS
    Vladimir Hlady; Fiscal Year: 2009
    ....
  32. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  33. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2001
    ..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
  34. Immunization to Reduce Genital and Neonatal Herpes
    Nigel Bourne; Fiscal Year: 2009
    ..These study designs may become standard for preclinical evaluation of HSV vaccines. ..
  35. Morpholino Antisense Drugs for Hepatitis C Virus
    Nigel Bourne; Fiscal Year: 2004
    ..The proposed research, if successful, would lead to a application for Phase II funding to bring the use of PMOs into the HCV drug market and provide a well-tolerated, inexpensive alternative to current HCV treatments. ..
  36. BIOSENSOR ARRAYS BASED ON SINGLE WALL CARBON NANOTUBES
    James F Rusling; Fiscal Year: 2010
    ..In addition to achieving our specific aims, this project should provide fundamental guidance for fabrication of sensitive microarray devices for a wide variety of biomedical applications. ..
  37. DESIGN AND SYNTHESIS OF NONPEPTIDE PROTEASE INHIBITORS
    Arun K Ghosh; Fiscal Year: 2010
    ..This research integrates organic synthesis, protein-ligand x-ray crystallography, molecular modeling and in-depth virus and cell-biological studies to design the next generation of HIV-1 protease inhibitors. ..
  38. Multifunctional Block Copolymer Scaffolds for Bone Repair
    Marcus Weck; Fiscal Year: 2010
    ..Optimization of the mechanical properties of the newly developed scaffolds will be part of a future application submission. ..
  39. ASTHMA AND EXPOSURE TO PEAKS IN PARTICULATE AIR POLLUT
    RALPH DELFINO; Fiscal Year: 2001
    ..This research is expected to have an impact on decisions regarding the protection of health in populations frequently exposed to higher particle excursions. ..
  40. DEVELOPMENT OF LIGAND ASSISTED ASYMMETRIC SYNTHESES
    Arun Ghosh; Fiscal Year: 2001
    ..Besides the broad range of scope and generality, this line of research will provide excellent opportunities to teach and train graduate and undergraduate students in the laboratory. ..
  41. SPECTROSCOPY OF BIOMEMBRANE MONOLAYERS
    Richard Dluhy; Fiscal Year: 2002
    ..abstract_text> ..
  42. DIRECT OBSERVATION OF INTERFACIAL PROCESS
    Vladimir Hlady; Fiscal Year: 2003
    ..Build a dynamic model of events based on the information that includes the two-dimensional map of biomaterial surface properties and the spatial-temporal distribution of individual plasma proteins. ..
  43. Evaluation of Exposure Measurement Error
    Elaine Symanski; Fiscal Year: 2004
    ..abstract_text> ..
  44. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  45. ISEA 2004 Conference
    Junfeng Zhang; Fiscal Year: 2004
    ..abstract_text> ..
  46. A Novel Polymer Trileaflet Heart Valve
    Leonard Pinchuk; Fiscal Year: 2005
    ..The primary outcome of Phase II will be the data required for an application to the FDA to obtain a Feasibility Investigational Device Exemption (IDE). Clinical trials will follow this approval. ..
  47. SYNTHESIS OF COCARCINOGENIC DITERPENES
    JAMES RIGBY; Fiscal Year: 2005
    ..These projected investigations should generate substantial new knowledge about complex synthesis as well as providing additional insight into some of the bioactivity exhibited by the subject natural products. ..
  48. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  49. GSH: Protecting Ovarian Follicles from Oxidant Injury
    Ulrike Luderer; Fiscal Year: 2006
    ..Finally, the research plan and career development activities outlined in this proposal will enable Dr. Luderer to successfully make the transition from mentored researcher to independent scientist-clinician. ..
  50. Pediatric Asthma, Particulate Air Pollution and NO2
    RALPH DELFINO; Fiscal Year: 2006
    ..Long-term goals are to improve knowledge about the independent and combined adverse effects of particulate and gaseous air pollutants by examining acute exposures and responses using ambulatory monitoring methods. ..
  51. SPECTROSCOPY OF BIOMEMBRANE MONOLAYERS
    Richard Dluhy; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  52. SYNTHESIS OF CYTOTOXIC GUAIANOLIDES AND OTHER TERPENOIDS
    JAMES RIGBY; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  53. Development of an Orbital Tissue Expander for Babies
    Leonard Pinchuk; Fiscal Year: 2003
    ..Phase II will be geared toward long-term in vivo testing of the device, stepping up production of the orbital expander for commercialization, regulatory submissions and clinical testing. ..
  54. New Methods for the Synthesis of Neurological Agents
    LARRY OVERMAN; Fiscal Year: 2008
    ..oryzae at 90 nM, suggesting potential antitumor activity. Because of the scarcity of these natural products from their natural sources, little biological evaluation has been carried out. ..